Hungarian Wound Care Society

Recent Progress in Polyphenol-Based Hydrogels for Wound Treatment and Monitoring - Mdpi.com
Article by Lulu Liu, Wenrui Ma, Junju Wang, Xiang Wang and Shunbo Li (China - Biosensors). This review aims to provide valuable insights for advancing polyphenol-based hydrogels, not only in their design, preparation, and application for wound healing and intelligent management but also in their future development potential.

Aging: the wound that never starts healing - Nature.com
Article by Mikolaj Ogrodnik (Vienna, Austria - Nature Communications). Here, it is argued that during aging, organs become locked in the early stages of the “healing process” that phenotypically correspond to the inflammatory phase. The damage responses activated within this state include the induction of cellular senescence, inflammation, LDs deposition, ECM remodeling, histolysis, and the infiltration of immune cells. Possibly, the “injury-like” perception of tissues undergoing aging originates from accumulated damage or its immediate consequences, such as DAMPs and PAMPs.

Smart Hydrogels in Wearable Electronics for Wound Treatments - Wiley.com
Article by Boyuan Li, Min Li and Yi Wang (Hong Kong, China - Small). By incorporating sensing, responsive controlled release, and dynamic interactive design, smart hydrogels enable dynamic wound treatment, demonstrating notable advantages. The advancements of smart hydrogels within the field of wearable electronics are summarized, elucidating their innovative fabrication techniques, critical functional properties, and integration into intelligent wound care systems through wearable technologies.

A Borate-Based Bioactive Glass Advances Wound Healing in Non-Healing Wagner Grade 1 Diabetic Foot Ulcers: A Randomised Controlled Clinical Trial - Wiley.com
Article by David G. Armstrong, Dennis P. Orgill, Robert D. Galiano, John Lantis et al. (USA - International Wound Journal). Based on the success of the trial, borate-based bioactive glass Fibre Matrix demonstrates faster healing of DFUs compared to SOC and should be considered in the treatment armamentarium for Wagner Grade 1 DFUs.

Wound Care Knowledge of Community Pharmacists and Pharmacy Staff: A Cross-Sectional Survey - Wiley.com
Article by Daisy H. K. Cheung, Carl R. Schneider, Jack C. Collins and Irene S. Um (Sydney, Australia - International Wound Journal). Findings highlight the need for targeted, evidence-based education programs and curriculum development for both pharmacists and particularly non-pharmacist staff to strengthen wound care knowledge and practice.

Hyaluronic Acid and Amino Acids in Wound Healing - Emjreviews.com
An ideal wound dressing should maintain moisture balance, encourage debridement, and support granulation and re-epithelialisation. Vulnamin’s combination of HA and amino acids provides many of these desirable features, offering a protective, regenerative approach to wound care. While secondary antibacterial dressings remain essential in infected wounds, this study highlights the potential of HA–amino acid formulations as a valuable tool in the management of hard-to-heal wounds.

> Innovative Wound Healing Strategy Through Amorphization of Active Pharmaceutical Ingredients as an Effective Approach for Hydrogel Formulation - Mdpi.com
Article by Miłosz Ignacyk,Zbigniew Krasiński, Bozena Michniak-Kohn and Judyta Cielecka-Piontek (Poland, USA - Pharmaceuticals). This review emphasizes the therapeutic potential of combining ASDs with hydrogel platforms, focusing on how these systems can speed up wound healing, minimize complications, and support personalized therapies.

Towards adaptive bioelectronic wound therapy with integrated real-time diagnostics and machine learning–driven closed-loop control - Nature.com
Article by Houpu Li, Hsin-ya Yang, Fan Lu, Wan Shen Hee et al. (USA - npj Biomedical Innovations). In preliminary studies using a large animal model, adaptive bioelectronic wound therapy (a-Heal) promoted tissue regeneration, reduced inflammation, and accelerated healing, highlighting its potential in personalized wound care.

Nanocomposite Biomaterials for Tissue-Engineered Hernia Repair: A Review of Recent Advances - Mdpi.com
Article by Octavian Andronic, Alexandru Cosmin Palcau, Alexandra Bolocan, Alexandru Dinulescu et al. (Bucharest, Romania - Biomolecules). The innovations highlight a transition toward personalized and regenerative hernia repair, aiming to improve durability, function, and patient quality of life.

Application of Antimicrobial Peptides in Wound Dressings - Dovepress.com
Article by Aoxun Zhu, Baiqi Chen, Jing Ma, Jiajia Wang et al. (China - Drug Design, Development and Therapy). The authors identify key challenges and propose future directions: rational design of tailored AMPs, smart controlled‑release carriers, nanotechnology‑enabled formulations, and strategies to accelerate clinical translation. Advances in these areas are expected to expedite the clinical adoption of AMP‑based wound therapies, offering safer, more effective, and personalized treatment options.

The Efficacy of Adjuvant Hyperbaric Oxygen Therapy in Chronic Wound Management: A Narrative Review - Cureus.com
Article by Sneha Sahay and Sung Yeon Kwak (United Kingdom). There was no evidence that HBOT worsened outcomes compared to traditional management; it was therefore recommended that it be considered earlier as an option for treatment-refractory wounds. When HBOT is unavailable or deemed inappropriate, it is recommended that other methods of oxygen delivery into the wound, such as oxygen dressings, be considered, to avail at least some of oxygen’s physiological benefits.

Emerging Biomedical Applications of Sustainable Cellulose Nanocrystal-Incorporated Hydrogels: A Scoping Review - Mdpi.com
Article by Dinuki M. Seneviratne, Eliza J. Whiteside, Louisa C. E. Windus, Paulomi (Polly) Burey et al. (Australia - Gels). This review highlights the pressing need for scalable, sustainable, and affordable CNC-based hydrogel systems that can democratise access to advanced biomedical technologies.

Timing of Preoperative Prophylactic Antibiotics - Woundsource.com
Article by Kirra Fedyszyn. The timing of preoperative antibiotic prophylaxis is more than a protocol item; it is a vital intervention that can significantly reduce the incidence of SSIs, protect surgical outcomes, and support wound healing across diverse clinical environments. For clinicians committed to excellence in wound care, attention to this narrow but impactful time window is a key component of patient safety.

Surgical Wound Classification – Understanding Postoperative Risk - Woundsource.com
Article by Jennifer J. Spector. Surgical wound classification remains a cornerstone of safe and effective perioperative management. With the CDC’s refined definitions, clinicians can more precisely assess infection risk, apply evidence-based interventions, and reduce the burden of SSIs. Emphasizing education and documentation around this system for the entire care team can help promote better patient outcomes and promotes better regulatory compliance in the surgical setting.

The Role of Probiotics in Healing Burns and Skin Wounds; An Integrative Approach in the Context of Regenerative Medicine - Mdpi.com
Article by Lenuta Ambrose, Ciprian Adrian Dinu, Gabriela Gurau, Nicoleta-Maricica Maftei et al. (Romania - Life). Based on a structured review of the literature — including in vitro models, animal experiments, and randomized trials with topical, enteral, and systemic administration of probiotic— authors identified four main mechanisms of action: modulation of the immune response by balancing cytokines and polarization of T lymphocytes; stimulation of tissue repair by increasing the proliferation of keratinocytes and fibroblasts, increased collagen synthesis, and induction of angiogenesis; direct antimicrobial activity against biofilms and multiresistant pathogens; and the restoration of eubiosis with the improvement of the function of epithelial barriers.

Choice of Primary Repair in Animal Bite Wound: A Novel Management Strategy - Wiley.com
Article by Yi-Shang Yu, Lin-Yin Wang, Shi-Wei Yang and Chih-Hsin Wang (Taipei, Taiwan - International Wound Journal). For high-risk wounds, early debridement and leaving the wound open after initial treatment proved effective. Primary repair of facial dog bite injuries, even complex ones, is safe and yields good aesthetic outcomes. For high-risk wounds, leaving them open after debridement is recommended to minimise infection risks.

Intervention in Healthcare Teams to Promote Adherence to the Integration of Care for People at Risk of Pressure Injuries Between Hospitals and Communities: A Scoping Review - Wiley.com
Article by Daniela Amêndoa, Lara Gugg, Carolina Gomes, Catarina Diniz et al. (Lisbon, Portugal - International Wound Journal). This scoping review aimed to identify interventions that increase multidisciplinary teams' adherence to the prevention and management of pressure injuries between hospitals and the communities.

Residual Sterile Muscle Fibrosis Following Partial Debridement of a Pressure Ulcer - Mdpi.com
Article by Joran Tilkin, Jos Velleman, Katarina Segers and Michel Van Brussel (Leuven, Belgium). Complex pressure ulcers in high-comorbidity patients present significant challenges in wound management. The concept of partial debridement with remaining sterile muscle fibrosis can serve as an interim solution, facilitating conservative wound healing.

Arthrospira platensis and Its Potential for Skin Regeneration in Animal Models as Support for Initiating Clinical Trials in Humans: A Systematic Review - Mdpi.com
Article by Sara Isabel Fernández, María Estefanía Hernández and Lina Andrea Gómez (Cundinamarca, Colombia - Biomedicines). The reviewed studies highlight the potential of Spirulina platensis to enhance wound healing, particularly in cases of diabetes and burns. Its antioxidant and anti-inflammatory properties play a crucial role in accelerating cellular regeneration and reducing inflammation, contributing to faster and more effective recovery.

Water-Driven Oxygen and Nitric Oxide Release from Porphyrin- and Mn-Based Metal–Organic Framework Enables Accelerated Acute Wound Healing - Acs.org
Article by Jieh-Neng Wang, Zih-Yu Tu, Wen-Jyun Wang, Wei-Peng Li et al. (Taiwan - ACS Applied Bio Materials). After adding the metal–organic framework (MOF) to fibroblast cell culture for O2 and NO supply, significantly accelerated migration and proliferation were obtained, providing strong evidence for the potential of the MOF in water-driven dual-gas therapy for wound care.

Preventing Surgical Wound Infections: Key Nursing Interventions - Woundsource.com
Article by Elizabeth Carradini. While SSIs remain a notable risk for all surgery patients, clinicians can improve outcomes by regularly undertaking numerous preventative measures before, during, and after surgery to reduce the likelihood of a surgical wound becoming contaminated.

UNMC researchers unveil ‘smart bandage’ that heals wounds faster - Unmc.edu
A groundbreaking new bandage developed by researchers at UNMC could transform wound care by accelerating healing and dramatically reducing scarring.

Development of Medical Device-Related Pressure Injury Risk Assessment Scale - Lww.com
Abstract by Handan Aydin Kahraman and Gulay Ipek Çoban (Erzurum, Turkey - Adv Skin Wound Care).

Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress - Frontiersin.org
Article by Rui Zhang, Suk Fei Tan, Ye Wang, Junxue Wu and Chao Zhang (China, Malaysia - Front. Cell Dev. Biol.). TCM-based hydrogels offer a novel, multi-functional platforms to diabetic wounds. They represent a novel paradigm in chronic wound management.

Resveratrol in Dermatological Therapy: A Critical Review of Mechanisms, Delivery Innovations, and Clinical Frontiers - Dovepress.com
Article by Quanrui Cui and Heping Wang (Harbin, China - Clinical, Cosmetic and Investigational Dermatology). This review consolidates robust preclinical evidence from animal models demonstrating RES-driven accelerated wound healing, diminished inflammatory markers, and significant tumor suppression while also appraising nascent yet promising clinical trial data that indicate good tolerability and initial efficacy in human subjects.

How Can Technology Improve Burn Wound Care: A Review of Wound Imaging Technologies and Their Application in Burns - UK Experience - Mdpi.com
Article by Nawras Farhan, Zakariya Hassan, Mohammad Al Mahdi Ali, Zaid Alqala et al. (Birmingham, UK - Diagnostics). Digital measurement tools offered accurate, non-contact assessment and supported telemedicine use. NICE recognized both LDI and MolecuLight as valuable tools with the potential to improve outcomes and reduce healthcare costs. Imaging technologies significantly improve the precision and efficiency of burn wound care.

Major Common Hallmarks and Potential Epigenetic Drivers of Wound Chronicity and Recurrence: Hypothesis and Reflections - Mdpi.com
Article by Alicia Tamayo-Carbón, Ariana García-Ojalvo, José Fernández-Montequín, William Savigne-Gutiérrez et al. (Havana, Cuba - IJMS). The list of epigenomic alterations and their significance in wound pathology is continuously escalating. The accurate identification of the key epigenetic priming codes of impaired healing, and their selective re-editing, will be remarkably beneficial.

Comparison of Single Use and Traditional Negative Pressure Wound Therapy Devices in Lower Extremity Ulcers: A US Real-World Evidence Analysis of NetHealth Data - Wiley.com
Article by Alison Garten, Leo M Nherera and Rodney Lindsay (USA - Int Wound J.). The results provide supportive evidence for using sNPWT for lower extremity ulcers (LEUs), demonstrating the opportunity to directly decrease the clinical burden of LEUs on patients. Subgroup analysis revealed a significant difference in wound closure rates for venous leg ulcer, while no significant difference was observed for diabetic foot ulcers.

Rapid and Esthetic Wound Healing in Surgery by Applying a Powdered Mixture of Mannose and Calcium Propionate - Springer.com
Article by Cristian Ionuţ Ciucanu, Sonia Raţiu, Sorin Olariu and Ionel Ciucanu (Timişoara, Romania - Aesthetic Plast Surg.). Bleeding time can be reduced by approximately 50% when the wound is treated with a mixture containing 40 moles of D-mannose per 1 mole of calcium propionate and wound healing time by approximately 40% compared to D-mannose. Both substances contribute to the destruction of pathogens and to the processes of new tissue formation, which accelerates the healing process. Treatment with this powdered mixture prevents skin scarring.

Effectiveness of Incisional Negative Pressure Wound Therapy (iNPWT) in the Prevention of Post-Amputation Complications: Systematic review & Meta-analysis - PubMed
Abstract by Ahmed Altaweel, Amr Meselhi, Hamza Marzouk, Hatim N Shahin et al. (Egypt, UK, Jordan, Germany - Ann Vasc Surg.).

Pulsed Electromagnetic Field Stimulation Therapy for Charcot Foot Ulcer: A Randomized Controlled Trial - Hmpgloballearningnetwork.com
Article by Norhan Mohamed Eltayeb, Marwa Mahdy Abdelhamid, Hossam Zaghloul Yousuf and Nessrein Afifi Abd-Elrashid (Cairo, Egypt - Wounds). PEMF therapy is an efficacious adjunctive treatment for Charcot foot ulcers, facilitating both wound healing and bone regeneration.

Made Easy: Periwound Maceration - Wounds-uk.com
Article by Kim Whitlock, Julie Bateman-Limmer and Lawrance Salter. Evidence highlights the importance of a proactive approach that prioritises prevention, early identification, and effective management of periwound skin complications, including cleansing, debridement, and optimisation of the wound environment. Wound care should aim to prevent damage, protect the periwound area, and restore its integrity when necessary. By incorporating periwound assessment into routine wound care practices, healthcare providers can adopt a more comprehensive, patient-centred approach to wound management.

Incidence of Surgical Site Infections at Skin Graft Recipient Sites with Negative Pressure Wound Therapy: A Meta-Analysis - Jprasurg.com
Article by Omar Shadida, Jennifer Novob, Raj Sainic, Ishith Sethd et al. (Australia - JPRAS). NPWT significantly lowers surgical site infection risk in skin grafts, particularly with traditional systems. Subgroup trends in trauma and lower-limb wounds are promising but not statistically significant and should be considered hypothesis-generating. Single-use NPWT requires further evaluation.

Pressure Injury Incidence and Risk Factors in Neonates Undergoing Surgical Intervention: A Prospective Study - PubMed
Abstract by Aynur Kocakap and Gülten Sucu Dag (Turkey - Int Wound J.).

Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host-Pathogen Interaction - PubMed
Abstract by Chaoming Chen, Xuanfan Hu, Da He, Xuemei He and Lan Shen (Geiju, China - Food Sci Nutr.).

Wound management, healing, and early prosthetic rehabilitation: Part 3 - A scoping review of chemical biomarkers - PubMed
Abstract by H. Williams-Reid, A. Johannesson and A. Buis (Scotland, Sweden - Can Prosthet Orthot J.).

Bioengineered Chitosan–Collagen–Honey Sponges: Physicochemical, Antibacterial, and In Vitro Healing Properties for Enhanced Wound Healing and Infection Control - Mdpi.com
Article by David Servín de la Mora-López, Leticia Olivera-Castillo, Jaime López-Cervantes, Dalia I. Sánchez-Machado et al. (Mexico - Polymers). The physicochemical, antibacterial, and biocompatibility properties of chitosan/collagen/honey sponges indicated their potential as a promising alternative for clinical use.

Elimination of the Wound Defect in Experimental Diabetic Foot Syndrome Using Collagen in Composite Form - Sapub.org
Article by Malikov Nodir Muzaffar Ugli, Ergashev Ulugbek Yusufjanovich and Iriskulov Bakhtiyor Uktamovich (Tashkent, Uzbekistan - American Journal of Medicine and Medical Sciences). As a result of treating the wound defect of the diabetic foot with composite collagen (collagen + quercetin), it was found that the acute exudative inflammation around the wound decreased earlier than in the wound of the remaining group of rats. In the dynamics of the conducted treatment, stabilization of dystrophic and destructive processes, activation of signs of reparative regeneration in the epidermis and dermis were observed, and on the 10th day, complete restoration of all cellular-fiber structures without signs of dystrophy and inflammation was revealed, and complete wound healing was noted (in the control group, the wound healed on the 14th day).

Preparation of Multilayer Platforms for Advanced Wound Care Management - Mdpi.com
Article by Amir Mohammad Sharafi, Sina Pakkhesal, Farnaz Monajjemzadeh, Nastaran Alipour and Samin Hamidi (Tabriz, Iran - Polymers). This review highlights the significant advancements made in the field of multilayer platforms for wound healing and underscores their potential as versatile therapeutic strategies.

3D printed antibacterial and anti-inflammatory scaffold containing vanillin-loaded Soluplus nanomicelles for healing of infected wounds - Nature.com
Article by Zainab Farooq Shafeeq, Fitua Al-Saedi, Eslah Shakir Rajab, Mastafa H. Al-Musawi et al. (Iraq, Georgia - Scientific Reports). In vivo studies on a full-thickness rat wound model showed that the Alg-F-VnNMs scaffold reduced inflammation, enhanced collagen deposition, and accelerated regeneration, leading to complete wound healing in 14 days, confirming its efficacy in wound management and skin repair.

Electrospun Biomaterials for Scarless Acne Wound Healing: Advances and Prospects - Mdpi.com
Article by Jiahui Chen, Liping Zhou, Zhongci Hang, Xiaochun Bian et al.(China - JFB). The authors explore the potential of electrospun nanofibers loaded with mesenchymal stem cells or exosomes as next-generation therapeutic systems aimed at promoting scarless acne healing.

Skin Substitutes: Evolution from Tradition to 3D Bioprinting - Bioengineer.org
The transition from conventional skin substitutes to innovative 3D bioprinting technologies highlights a significant advancement in medical science. This evolution not only embodies the promise of healing but also raises extraordinary expectations for improved patient outcomes. As this field continues to evolve, it represents a leap towards the realization of fully functional artificial skin that can not only replace but also enhance human tissue in unimaginable ways.

The Impact of a Multidisciplinary Patient Education Program on Venous Leg Ulcer Healing: A Randomised Controlled Trial - Wiley.com
Article by Sebastian Probst, Camille Saini, Paul Bobbink, André Frei et al. (Switzerland, Ireland - Wound Repair Regen.). Nurse-led education improved early healing and patient engagement. Sustained behaviour change may require longer-term support and targeted nutritional interventions. Future research should explore adaptive education models and digital tools for long-term venous leg ulcers management.

The Human Amniotic Membrane: A Rediscovered Tool to Improve Wound Healing in Oral Surgery - Mdpi.com
Article Maurizio Sabbatini, Paolo Boffano, Martina Ferrillo, Mario Migliario and Filippo Renò (Italy - IJMS). Despite its proven therapeutic benefits, the hAM remains underutilized in dentistry due to challenges related to its preparation and storage. This review aims to highlight its potential and encourage broader clinical adoption in regenerative oral surgical practices.

Incidence and risk factors of intraoperative acquired pressure injury in open heart surgical patients: a meta-analysis of prospective studies - Nih.gov
Article by Zhihao Fang, Tian Chen, Weixi Zheng, Qiuyu Chen et al. (Fuzhou, China - Eur J Med Res.). This study assessed the incidence of intraoperative acquired pressure injuries in open heart surgical patients and identifies key risk factors, including prolonged surgical duration, advanced age, female sex, and perioperative corticosteroid use. However, the results should be interpreted with caution due to the high heterogeneity observed across studies.