Hungarian Wound Care Society

Optimized Wound Healing Assay to Study Extracellular Vesicle-Driven Glioblastoma Cell Migration - Mdpi.com
Article by Concetta D’Antonio, Francesca Mantile, Gabriella Pocsfalvi and Giovanna L. Liguori (Naples, Italy - MPs). The authors outline a step-by-step description of the procedure, detailing all required materials and equipment and highlighting critical steps, checkpoints, and key parameters. This method provides a robust framework for reproducible wound healing assays to investigate EV effects on GB cell migration.

Navigating Serous Drainage: What It Means for Your Health - Yourhealthmagazine.net
Serous drainage is typically normal in wound healing. Observe changes in volume, color, or odor that may indicate infection. Maintain cleanliness and proper dressing changes. Consult medical professionals if changes or concerns arise. Other drainage types can help identify healing stages and issues.

Regulatory T Cells in Diabetic Wound Healing: A Comprehensive Review - Sciencedirect.com
Article by Ayda Khatibi, Mozafar Khazaei, Sepehr Zamani, Mostafa Al Jaf and Leila Rezakhani (Iran - Regenerative Therapy). This article explores the potential of 3D-printed decellularized biomaterial scaffolds in revolutionizing wound healing, emphasizing their role in improving regenerative outcomes and reducing the risks of complications.

Regulatory T Cells in Diabetic Wound Healing: A Comprehensive Review - Tandfonline.com
Article by Jiezhi Lin, Yingying Liu, Peiyao Min, Hui Zhao et al. (China - J of Inflammation Research). This review aims to provide novel insights and directions by analyzing the most recent literature on future therapeutic strategies for managing diabetic wounds.

Rapid Senescence Onset in Skin Cells Aids Wound Healing - The-scientist.com
Article by Shelby Bradford. In mice, keratinocytes become senescent within just hours after an injury through a novel regulatory mechanism, revealing a new paradigm for cellular senescence.

Living bandage accelerates healing across multiple wound types - Medicalexpress.com
Edited by Gaby Clark. Chronic wounds remain a significant clinical challenge, in part because it is difficult to deliver sustained, localized immune signals that coordinate tissue repair. While cytokines play a central role in regulating inflammation and healing, conventional delivery approaches are often limited by rapid degradation and poor retention at the wound site. Researchers at Rice University with the support of the Rice Biotech Launch Pad have developed a cytokine factory patch designed to address this challenge by continuously producing and delivering therapeutic cytokines directly within the wound environment.

Electricity Can Renovate Even the Worst Type of Wounds - Ijpsjournal.com
Article by Vendra Sruthi and Bonthu Bhavani (Bhimavaram, India - Int J Pharmaceutical Scie). The researchers claim to heal chronic wounds three times faster using electric current showing majority of improvement.

Duration of Wound Coverage for the Prevention of Surgical Site Infections After Surgery: A Systematic Review of Current Evidence With Meta‐Analysis of Randomised Controlled Trials - Nih.gov
Article by Moira D Cruickshank, Kirsty Loudon, Paul D Manson, George Ramsay and Miriam G Brazzelli (UK - Int Wound J.). The authors' findings add to the evidence showing that shorter and longer dressing durations are comparable in terms of surgical site infection risk.

A machine-learning–based risk model for predicting wound healing after revascularization in patients with chronic limb-threatening ischemia - Jvsvi.org
Article by Kentaro Inoue, Koichi Morisaki, Shun Kurose, Atsushi Guntani et al. (Japan - J of Vasc Surgery, Vascular Insights). The ML-based model showed acceptable predictive performance for 1-year wound healing in patients with CLTI. Systemic factors, including low albumin, anemia, and advanced age, were identified as key determinants, underscoring the importance of comprehensive systemic management in addition to revascularization.

Comparative evaluation of wound healing with different treatments in rats: Cytokine modulation, histological remodeling, and scar outcomes - Rrml.ro
Article by Nino Kuridze, Sophio Giorgadze, Luiza Gabunia, Ketevan Ghambashidze et al. (Tbilisi, Georgia - Romanian Journal of Laboratory Medicine). PS produced the most favorable and accelerated recovery pattern, Sil and BMt provided moderate benefit, and Hep displayed slower reparative capacity.

Self-Reported Emotional States and Psychosocial Patterns in Patients With Active Venous Leg Ulcers (CEAP C6): A Descriptive Cross-Sectional Study - Cureus.com
Article by Fernando Vega-Rasgado, Lourdes A. Vega-Rasgado, Fernando J. Vega-Riveros, Alikvahan M. Jiménez Corales and Fernando Contreras Cisneros (Mexico). The authors' findings suggest that incorporating psychological assessment and support could be considered a potentially relevant component of comprehensive care for these patients, alongside traditional hemodynamic management.

Development and evaluation of a propolis, tea tree oil, and jojoba oil nanoemulgel with enhanced antioxidant, anti-inflammatory, and wound-healing activities - Nature.com
Article by Mariam H. Saad, Soha M. Kandil, A. Farid, Gehan Safwat et al. (Egypt - Scientific Reports). The developed green formula, resulting from both the low-energy, environmentally friendly preparation method and the natural origin of its constituents, was demonstrated to be an antioxidant and inflammatory and to accelerate wound healing, suggesting it could be used as a natural formula for topical wound healing application.

Negative Pressure Wound Therapy Versus Conventional Dressings After Debridement for Necrotizing Fasciitis or Gas Gangrene: Impact on Hospital Stay and Wound Closure Methods - Cureus.com
Article by Juri Sugiyama, Yasuhiko Takegami and Satoshi Muto (Nagoya, Japan). In the management of necrotizing fasciitis or gas gangrene, NPWT was associated with significantly longer hospital stay and more complex wound closure procedures, without clear benefits in functional recovery at discharge. These findings suggest that while NPWT may be useful for local wound management, its routine use should be approached with caution, and careful patient selection remains essential.

New versatile option for diabetic wound care, UJ study finds - Uj.ac.za
In diabetes, high blood sugar and low oxygen cause skin-repair cells to malfunction, which stalls the healing process. Current therapies for diabetic wounds only achieve about a 50% healing rate, and there is a 50% chance the wounds will return. Because of the high risk of these wounds not healing and lower limb amputation, there is an urgent need for more effective wound treatments. A possible answer lies in a therapy being researched at the UJ Laser Research Centre, called photobiomodulation (PBM). PBM is also called “light therapy” or “red light therapy”. It is a safe, gentle method that uses specific colours of light to help the body heal, using red or near-infrared light.

Preparation and Application of Sodium Alginate-Based Composite Hydrogels in Wound Dressings - Mdpi.com
Article by Dandan Chen, Yan He, Xinyue Zhang, Longyi Nan et al. (China - Gels). This review aims to provide a theoretical basis for the development of novel sodium alginate-based composite hydrogels for wound dressings and to promote their clinical translation and practical application in this field.

Palliative Wound Care. Recommendations for the Management of Wound-related Symptoms - Ewma.org
EWMA is pleased to announce the release of a new EWMA Document that synthesises the latest evidence and provides recommendations for managing symptoms in palliative wounds. This resource aims to support healthcare professionals in selecting the most effective strategies for palliative wound care, ultimately improving patient outcomes, advancing research, and enhancing education in this crucial field.

Comparative effectiveness of debridement strategies for chronic lower-extremity wounds: a systematic review and network meta-analysis - Frontiersin.org
Article by Guorui Li, Xiaoyun Zhang, Suiyi Liu, Lin Chen and Sha Liu (China - Front. Med.). The comparative profile of debridement strategies varied by the outcome. Biological and enzymatic debridement ranked favorably for wound healing and complete debridement, whereas enzymatic and autolytic debridement were associated with lower pain scores. Ultrasound-assisted debridement may be more efficient in terms of procedure time. These findings should be interpreted cautiously because ranking probabilities do not establish clinically decisive superiority, especially when evidence is sparse or heterogeneous.

Comprehensive Approaches to Burn Scar Management - Intechopen.com
Article by Chandler Hinson, Kimberly A. Donnellan, Andrew C. Bright and Kevin Slaughter. Advances in regenerative biology and technology are steadily transforming the outlook for patients, shifting scar care from mere mitigation toward functional and aesthetic restoration. Yet, the human element remains central: successful outcomes depend on multidisciplinary collaboration, long-term follow-up, and patient-centered care. The management of burn scars is not only a technical pursuit but also a profoundly human one – dedicated to restoring identity, confidence, and quality of life to those who have endured devastating injuries.

Natural-Origin Bioadhesive Injectable Hydrogels Composed of Polyphenol and Chitosan with Antibacterial Activity for Wound Healing - Mdpi.com
Article by Hongyu Zheng, Shikui Wu, Yujie Liu, Yuzhu Zhang et al. (Hohhot, China - Gels). The authors' findings support the use of polyphenol–chitosan composite hydrogels as promising wound-dressing candidates and highlight the value of a side-by-side comparison of PCA, GA, and TA for understanding structure–property–function relationships in this class of materials.

Breakthrough drug reverses aging in skin and dramatically speeds healing - Sciencedaily.com
Scientists have discovered that a topical anti-aging drug called ABT-263 can dramatically improve wound healing in older skin. The treatment works by removing damaged “senescent” cells that accumulate with age and slow the body’s repair process. In aged mice, wounds healed much faster after treatment, while the drug also activated genes tied to collagen production and tissue regeneration.

Outcome of Vacuum-Assisted Closure Technique in Skin Grafting Over Anatomically Challenging Areas - Cureus.com
Article by Md. Bayzid Bostamy, Aminur Rahid, Abid Azad, Masfik Ahmad et al. (Dhaka, Banglades - Cureus China). VAC-assisted dressing was associated with favorable graft take and few short-term postoperative complications in anatomically challenging wound sites. However, due to the observational design, small sample size, absence of formal power analysis, and lack of a standard dressing control group, these findings should be interpreted cautiously and cannot establish relative efficacy compared with conventional dressing methods.

Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro - Wiley.com
Article by Daniela Enriquez-Ochoa, Raji R. Nagalla, Yingzi Liu, Christian F. Guerrero-Juarez et al. (Irvine, USA - FASEB Journal). The authors' findings reveal the integration of contact-dependent calcium and connexin signaling with transcriptional remodeling to coordinate macrophage-fibroblast behavior during healing.

Clinical and Operational Outcomes Associated with the Adoption of a Digital Wound Care Solution in Home Health Settings - Mdpi.com
Article by Heba Tallah Mohammed, Robert D. J. Fraser, Tameka McCabe and Amy Cassata (Canada, USA - Healthcare). This study provides preliminary evidence that implementing a DWCS in wound care model within HH environments is associated with improvement in both clinical and operational metrics.

Vitamin C for Improved Wound Healing - Pharmacytimes.com
Article by Gunda Siska. From a clinical perspective, healthy skin means a healthy body. Healthy skin means quick wound healing. High vitamin C levels in the skin greatly assists wound healing and minimizes raised scar formation. This has been demonstrated in numerous clinical studies in humans and animals.

Comparative study on the wound healing effects of local versus systemic application of Polymyxin B in mice infected with multidrug-resistant Pseudomonas aeruginosa - Frontiersin.org
Article by Chenhu Ma, Dan Wang, Bingjie Zhang, Jianshe Xu et al. (Nanjing, China - Front. Microbiol.). No definitive conclusion can be drawn regarding potential synergistic or antagonistic effects of combination therapy based on this study design. This suggests that targeted local administration may represent a more effective and cost-efficient strategy for localized infections caused by resistant bacteria, which warrants further clinical translational research.

Examining Convexity in Ostomy Management - Woundsource.com
Reviewed by:Jennifer J. Spector. The importance of convexity in ostomy management lies not only in its clinical utility but in its role as a marker of advanced assessment and decision-making. Understanding when and how to use convexity requires a nuanced appreciation of anatomy, product design, and patient-specific factors. In a field where small adjustments can have significant impacts, the ability to optimize pouch fit represents a critical competency.

Inflammation and wound healing: a comprehensive overview of mechanisms, therapeutic strategies, and translational perspectives - PubMed
Abstract by Yixiao Zhang, Dezhi Guo, Lizhou Song, Guowei Su et al. (China - Biomark Res.).

The Multifunctional Peptide AP10W Enhances Skin Wound Healing Through Macrophage Reprogramming and Angiogenesis - Mdpi.com
Article by Cuiling Xuan, Zixuan Liu, Peng Zhang, Bojian Liu et al. (Weifang, China - Biomolecules). The authors' findings identify AP10W as a multifunctional peptide with potent wound-healing properties, positioning it as a promising candidate for wound therapy.

Small patients, big obligations: Ending the copy-paste in paediatric wound care - Globalwoundcarejournal.com
Article by Paulo Alves, Liliana Abreu and Rita Cabral (Global Wound Care Journal). We keep cutting adult cloth to fit children, then act surprised when the seams split. Paediatric wound care still leans on shrunken-down adult protocols and products, a habit that ignores the distinctive physiology, psychology and development of infants, children and adolescents. It is not merely suboptimal; it is ethically questionable. The result is avoidable pain, stalled healing and needless suffering in a vulnerable population.

Development and overview of international recommendations for therapeutic wound and skin cleansingtric wound care - Globalwoundcarejournal.com
Article by Emily Haesler, Terry Swanson, Dot Weir, Geoff Sussman and Donna Larsen (Global Wound Care Journal). Therapeutic wound cleansing is a crucial and fundamental component of effective wound care yet remains inconsistently understood and performed across clinical settings and international contexts. In response to this inconsistency, the International Wound Infection Institute (IWII) convened a multidisciplinary Expert Working Group to review the best available evidence and develop practical, evidence-based recommendations.

A retrospective analysis on the effectiveness of ibuprofen versus conventional dressings in the treatment of diabetic foot ulcers - Globalwoundcarejournal.com
Article by Afroditi Fotiadou, Kyriacos Evangelou, Georgios Fanariotis, Nikolaos Bekas et al. (Global Wound Care Journal). Surgical debridements and limb amputations are routinely performed for diabetic foot ulcers but predispose to pain and infection. This study aimed to evaluate the impact of ibuprofen dressings on healing and quality of life in diabetic foot ulcers postoperatively. A four-year retrospective analysis was conducted at a university hospital. Patients received Ibuprofen, vacuum-assisted closure devices, foam, foaming silicone, conventional, collagen, or hydrofiber dressings.

Multifunctional Silk Fibroin Hydrogel with Antibacterial and Regenerative Properties for Accelerated Wound Healing - Mdpi.com
Article by Yanjiao Wu, Jiayue Chen, Luyao Han, Yiqiong Zhang and Li Wei (Shanghai, China - Gels). The multifunctional PBCTS@PNF hydrogel provides a potent bioengineered therapeutic platform for wound healing management through the synergistic interplay among antibacterial, anti-inflammatory, and tissue regenerative functionalities.

Skin Substitutes for Wound Healing: What Patients Need to Know - Royalwoundcare.com
Many assume that wounds naturally heal with time, rest, and basic wound care. And while this is the case for minor injuries, more complex wounds require a different level of care. This is where advanced treatments, such as skin substitutes, become invaluable. Skin substitutes are innovative medical therapies designed to support wound healing when the body cannot repair damaged tissue as effectively on its own. More specifically, skin substitutes are commonly used in the treatment of chronic wounds, diabetic foot ulcers, and severe burns—complex injuries for which traditional wound care may not be enough.

The Multifunctional Peptide AP10W Enhances Skin Wound Healing Through Macrophage Reprogramming and Angiogenesis - Mdpi.com
Article by Cuiling Xuan, Zixuan Liu, Peng Zhang, Bojian Liu et al. (Weifang, China - Biomolecules). The authors' findings identify AP10W as a multifunctional peptide with potent wound-healing properties, positioning it as a promising candidate for wound therapy.

Can a Chatbot Help Heal a Wound? Context-Aware Prompts for Boosting Adherence in Diabetic Foot Ulcers - Mdpi.com
Article by Aria Rabet, Aminreza Khandan, Arian Rabet, Mohammad Dehghan Rouzi et al. (Los Angeles, USA - Diabetology). Smart offloading technologies enable the real-time, objective monitoring of adherence in patients with diabetic foot ulcers (DFUs). Although remote tracking may reinforce adherence and improve wound healing, effectiveness depends on sustained device use, particularly as devices are often removed during rest periods. Real-time, behavior-contingent feedback informed by sensor data, including AI-supported messaging capable of detecting nonadherence, may enhance reinforcement.

Silver-Functionalized Silk Fibroin Films: Development and Characterization for Antibacterial Wound Dressings - Mdpi.com
Article by Annalia Masi, Rebecca Pellegrino, Federica Paladini and Mauro Pollini (Lecce, Italy - Macromol). The authors' results demonstrate that silver functionalization process improves the structural stability of silk fibroin while conferring sustained antibacterial activity, thus supporting their potential application as antimicrobial dressings for the treatment of superficial and low-exudate wounds.

A Review on Transdermal Patches for Wound Healing - Ijpsjournal.com
Article by Aasawaree Mane, Mahek Godia, Aneeta Gupta and Deepali Jadhav (Karjat, India - Int. J. Pharmaceutical Scie.). The review aims to describe the concepts, terminology, methods, limitation and future need related to the use of transdermal patches.

Characterization of cutaneous wound healing in swine - Sciencedirect.com
Article by Hsin-ya Yang, Kan Zhu, Anthony Gallegos, Cynthia Recendez et al. (USA - JID Innovations). The data provide a detailed, multiparameter map of the immune; structural; and neural milestones in porcine wound healing, establishing baseline benchmarks for normal wound repair, supporting the development of machine learning tools for wound assessment.

Slough as More Than Nonviable Tissue: Combining Microbiological and Clinical Perspectives on Continuous Wound Bed Preparation for Optimal Wound Healing - Woundsource.com
Article by Dot Weir and Lindsay Kalan. Slough is a common feature of wounds, composed mainly of accumulating devitalized tissue that varies in clinical presentation, with ranges of color, texture, thickness, and adherence. Slough has previously been described as non-functional tissue in the wound bed; however, our more recent understanding of slough has evolved into far more than just passive debris requiring debridement.

Wound Exudate and Healing: Why Moisture Balance and MMP Activity Matter - Woundsource.com
Edited by Jennifer J. Spector. Wound exudate is not just a byproduct of healing—it is a dynamic indicator of the wound environment. Understanding its biochemical composition, particularly in chronic wounds, is essential for identifying stalled healing and improving patient outcomes.

Dual Arnica montana and Ruscus aculeatus Hyaluronic Acid-Modified Nanostructured Lipid Carriers for Accelerated Wound Healing Effect - Mdpi.com
Article by Ioana Lăcătusu, Robert Tincu, Mihaela Bacalum, Diana Lavinia Stan et al. (Bucharest, Romania - Antioxidants). The authors' results facilitate the design of remarkable hybrid lipid nanocarriers, which exploit the emergence of a pharmacological phytochemical’s synergy, and which could contribute to stimulating signalling pathways and promoting appropriate cellular regeneration, needed for wound healing.

Clinical Evaluation of a Novel Synthetic Nanofiber Wound Matrix for the Treatment of Chronic Wounds - Nih.gov
Article by Lifang Qian, Jingyun Fang, Yong He, Meiqin Ni et al. (China, USA - Int Wound J.). The authors' results demonstrated that the subject wound matrix is a safe and effective novel technology in treating chronic wounds, providing significant clinical and economic benefits for patients with various chronic wounds.

Statin Therapy Reduces Wound Healing Time by 30% - Consultant360.com
There are a number of potential benefits that could be realized from an appropriately conducted human trial including optimal delivery methods, dosage, and duration of treatment as well as the most obvious finding—demonstrating the benefit of statins in human patients.

Incidence of Wound Infection After Abdominoplasty: A Retrospective Observational Study - Cureus.com
Article by Salman B. AlNajjar, Suja AlZayer, Isa AlNajjar and Dalal A. Yusuf (Bahrein). Targeted management of symptoms such as fever, discharge, and warmth may significantly reduce wound infection risks after abdominoplasty. Preoperative measures such as weight management and smoking cessation, combined with standardized wound care protocols, are recommended to improve outcomes.

Hydrogel-Based Platforms for Wound Care: Integrated Strategies for Antimicrobial Delivery and Biofilm Management - Mdpi.com
Article by Gabriela Marcelina Mihai, Liviu Martin, Lucretiu Radu, Madalina Aldea et al. (Romania - Gels). The authors discuss the main translational priorities, including more predictive preclinical models, long-term nanomaterial safety, harmonized outcome reporting, manufacturing scalability, and health economic evidence, as areas where further work can meaningfully accelerate clinical adoption.

Research on Silver-Based Wound Dressing: An Ontological Analysis - Mdpi.com
Article by Prabir K. Dutta, Thant Syn and Arkalgud Ramaprasad (USA - Antibiotics). This review is the first attempt at making an ontological map of the research on antimicrobial silver for wound dressings. This issue is logically constructed as: the use of silver species on nanosupports deposited on a matrix, with antimicrobial effectiveness assayed by methods to promote wound healing of chronic wounds as determined by recovery.

Maintenance Debridement in Chronic Hard-to-Heal Wounds: Toward Dynamic Homeostasis and Precision Intervention - PubMed
Abstract by RuoDi Lu, Yi Zhang and Biao Cheng (Guangzhou, China - Int Wound J.).

Phytochemical-Loaded Nanotherapeutics in Cosmetic Surgery Wound Healing: A Narrative Review - Mdpi.com
Article by Bhagavathi Sundaram Sivamaruthi, Natarajan Suganthy, Periyanaina Kesika, Khontaros Chaiyasut et al. (Thailand, India - Cosmetics). The key insight of this review is that phytochemical-loaded nanotherapeutics represent a promising but still transitional strategy, biologically compelling at the preclinical level yet clinically under-validated. Bridging this gap requires rigorously designed clinical trials, quantitative outcome reporting, and balanced regulatory frameworks. Advancing these areas will be essential to translate nano-enabled phytochemicals from experimental systems into reliable, evidence-based solutions for cosmetological wound management.

Adjuvant Radiotherapy Following Surgical Excision of Keloids: A Systematic Review of Dose, Fractionation, and Recurrence - Mdpi.com
Article by Monika Wojarska, Klaudia Kokot, Wiktoria Borzyszkowska, Patryk Boczar et al. (Gdańsk, Poland - Life). The findings suggest that the combination of surgery and postoperative radiotherapy may be associated with reduced recurrence rates compared with surgery alone. However, the variability in treatment protocol and study design makes direct comparisons challenging, and the observed differences in outcomes could be influenced by multiple factors, including lesion characteristics, radiotherapy technique, and patient-related variables.

Promoting Wound Regeneration Through Targeted Suppression of Chronic Inflammation with Active Molecular Chitosan - Mdpi.com
Article by Ji Eun Yoo, Zio Song, Yong Hyun Lee and Jae Kweon Park (South Korea, Gels). The authors' results suggest that hydrogels containing AMC may enhance both antibacterial and anti-inflammatory properties, potentially promoting wound healing.

The impact of postgraduate wound care qualifications on clinical practice, confidence and career progression: results from a global survey - Cambridgemedia.com.au
Article by Peta Ellen Tehan, Adriana Tiziani, Dimitri Beeckman, Samantha Holloway and Sebastian Probst (Australia, UK, Ireland - J. of Wound Management). Postgraduate wound care education plays a crucial role in enhancing clinical competency and contributes to career development. However, financial constraints limit accessibility of education and institutional barriers limit implementation of new knowledge. Addressing these challenges through credentialing and benchmarking, increased institutional support, and policy changes could optimise the benefits of postgraduate education and strengthen evidence-based wound care practices globally.

Understanding psychological wellbeing in the context of delayed wound healing: a scoping review - Cambridgemedia.com.au
Article by Edgar Mandeng Ma Linwa, Victoria J Clemett and Crina-Daniela Grosan (London, UK - J. of Wound Management). Standardised tools are needed to assess psychological wellbeing in DWH. Future research should prioritise underrepresented dimensions (such as personal growth, purpose) to inform targeted interventions.

Clinical and microbiological outcomes of topical mupirocin-corticosteroid treatment for infected wounds in Wistar rats - Cambridgemedia.com.au
Article by Oluwatosin Stephen Ilori, Tomiwa Williams Adeniji, Olusola Olateju Akanbi, Oluwatosin Ruth Ilori and Abdul Rasheed Olayemi Saliu Grosan (Ogbomoso, Nigeria - J. of Wound Management). This study revealed that the combination of mupirocin and betamethasone is more efficacious in promoting wound epithelialisation and wound bacteria.