Hungarian Wound Care Society

Topical Oxygen Therapy in Wound Healing: A Narrative Review of Mechanisms and Modalities - Auctoresonline.org
Article by Sriram V. S., Ravi Kumar Chittoria and Amrutha J. S. (Pondicherry, India - International Journal of Clinical Case Reports and Reviews). By summarizing current evidence and emerging trends, this review aims to provide clinicians and researchers with a comprehensive understanding of how oxygen therapy can be integrated into effective wound care strategies.

Prophylactic Application of Closed-Incision Negative Pressure Therapy in a High-Risk Emergency Laparotomy: A Case Report - Cureus.com
Article by Swapnil Tripathi, Avinash Ray, Tanya Dhawan and Mohammed Athif Khan (UK, India). This report underscores the value of ciNPT as an adjunctive tool in surgical wound management in high-risk abdominal surgeries to reduce complications and facilitate recovery.

Influence of extracorporeal shockwaves on macrophage polarization in a 3D collagen matrix - Sciencedirect.com
Article by Diana Heimes, Moritz Große-Leege, Nadja Engel, Katharina Peters et al. (Germany - Regenerative Therapy). Clinical evidence suggests that ESWT can effectively promote tissue healing and regeneration, indicating that the observed results may reflect limitations in the chosen model or cell type rather than the therapy itself, warranting further investigation.

Efficacy of Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Meta-Analysis of Randomized Controlled Trials - Sagepub.com
Abstract by Xiang-Hui Mei, Tong Zhang, Yan Yang, Li Sun et al. (Handan, China - The International Journal of Lower Extremity Wounds).

In Vitro and In Silico Wound-Healing Activity of Two Cationic Peptides Derived from Cecropin D in Galleria mellonella - Mdpi.com
Article by Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Maria Camila Moncaleano, Yamil Liscano et al. (Colombia, Spain - Antibiotics). The authors' findings suggest that the structure and cationic charge of the short peptide facilitate robust interactions with growth factor receptors, enhancing re-epithelialization and tissue regeneration. Consequently, this peptide is a promising candidate ligand for the treatment of chronic wounds and associated infections.

Hyaluronic acid skin booster injection and cold laser therapy in oral wounds: an experimental study - Oaepublish.com
Article by Noury Adel and Nenad Stankovic (Egypt, Serbia - Plastic and Aesthetic Research). The combination of cold laser therapy and hyaluronic acid skin booster injections significantly accelerated wound healing following both laser and scalpel incisions. Notably, wounds created using the 976 nm diode laser showed superior healing outcomes compared to those made with a scalpel.

The Role of Communication in Managing Chronic Lower Limb Wounds - Dovepress.com
Article by Davide Costa and Raffaele Serra (Catanzaro, Italy). This review provides a foundation for future research on how evolving communication methodologies can further enhance patient outcomes and reduce disparities in wound care management worldwide.

The Role of African Medicinal Plants in Dermatological Treatments: A Systematic Review of Antimicrobial, Wound-Healing and Melanogenesis Inhibition - Mdpi.com
Article by Lubna M. S. Elmahaishi, Farzana Fisher, Ahmed Hussein and Charlene W. J. Africa (Bellville, South Africa - Cosmetics). This study highlights the broad therapeutic potential of African medicinal plant extracts in addressing various health conditions, including skin infections, wound management, and skin pigmentation. While several extracts demonstrated strong bioactivity, inconsistent reporting of statistical data limited quantitative synthesis.

Surgical Site Infections Across the Continuum of Care: Recognizing the Risk Factors and Causes - Woundsource.com
Article by Kirra Fedyszyn. Surgical site infections present a major clinical challenge, accounting for a significant proportion of postoperative complications across surgical disciplines. Their impact is far-reaching: extended hospital stays, delayed wound healing, increased costs, and in severe cases, higher morbidity and mortality.

A simple and specific colorimetric biosensor for early detection of Pseudomonas aeruginosa wound infections - PubMed
Abstract by Liubov Shishaeva, Zhihao Li, Flavia Zuber, Vivian Zulian et al. (Switzerland, USA - Biosens Bioelectron.).

Advances in Gelatin-Based Tissue Engineering Using HRP/H2O2 - Mdpi.com
Article by Marino Basha, Ahmad Aburub, Filippos F. Karageorgos, Georgios Tsoulfas and Aleck H. Alexopoulos (Thessaloniki, Greece - Gels). A comprehensive review of two databases (Scopus and Web of Science) was conducted. The data extracted from each study included the materials used for each application, methods used for material preparation, cells used in the tissue engineering application, laboratory animals used, and whether computational/simulation techniques were implemented.

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains - Rupress.org
Article by Sabina Elmi and Jesper Nylandsted (Copenhagen, Denmark - JCB). In a new study published in Journal of Cell Biology, Williams et al. identify a coordinated, two-step repair mechanism that depends on annexins and calcium-dependent calpain proteases. Their findings show that annexins form a transient "scab" over the wounded area, stabilizing the membrane and that calpains subsequently cleave annexins, facilitating the release of this structure as annexin-containing microvesicles.

Optimizing Cellular Metabolism Through Mass Balance Analysis to Improve Skin Wound Healing - Mdpi.com
Article by Luis Ramirez Agudelo, Gabriel Yarmush, Suneel Kumar and Francois Berthiaume (Piscataway, USA - Biology). The Recon database was analyzed computationally to identify glycine and glutamine as the most likely metabolites to enhance ATP and biomass synthesis during both unrestrained and restrained oxygen uptake, which more closely mimics hypoxia in chronic skin wounds.

White Paper – Wound balance: Achieving wound healing with confidence - Woundsinternational.com
Article by Alison Garten, Christine Blome, Florian Dumas, Hans Smola et al. (Wounds). The concept of ‘wound balance’ is multifactorial, encompassing interconnecting issues related to the wound healing process and clinical practice. The wound balance concept aims to integrate various critical parameters which offer continuity, individualised care and support clinical decision-making, to place the patient at the centre of all care.

The Potential Role for a Painless Enzymatic Debridement Gel in Wound Bed Preparation for Venous Leg Ulcers - A Dose Escalation Study - Wiley.com
Article by David Goldsmith and David M. Fairlamb (Cambridge, UK - International Wound Journal). Pain from surgical/mechanical debridement can be reduced by topical anaesthetic creams; however, this requires at least 30–60 min of application and subsequent removal prior to debridement, making it impractical to use in busy clinic facilities.

Impact of Polyhexanide Care Bundle on Surgical Site Infections in Paediatric and Neonatal Cardiac Surgery: A Propensity Score-Matched Retrospective Cohort Study - Wiley.com
Article by Gianluca Castiello, Giuseppe Caravella, Greta Ghizzardi, Gianluca Conte et al. (Italy - International Wound Journal). The comprehensive nature of the PHMB care bundle, including educational programs, preoperative and postoperative antimicrobial treatments, and consistent application of best practices, was instrumental in achieving the outcomes. Implementing antimicrobial care bundles could significantly reduce SSIs in paediatric cardiac surgery.

Research Progress of Multifunctional Hydrogels in Promoting Wound Healing of Diabetes - Dovepress.com
Article by Jiansong He, Jiemei Chen, Taotao Liu, Fuli Qin and Weipeng Wei (Nanning, China). This paper systematically analyzes the existing challenges and explores the future research directions, and emphasizes the potential of multifunctional hydrogels in improving wound healing of diabetes and their clinical application prospects.

In Vitro Modulation of Macrophage Inflammatory and Pro-Repair Properties Essential for Wound Healing by Calcium and Calcium-Alginate Dressings - Mdpi.com
Article by Yara Adib, Kevin Serror, Jose Amaya Pinzon, Laura Duciel et al. (Paris, France - Cells). This work demonstrates the interest in calcium alginates for stimulating macrophage subtypes, which could help restore wound healing, especially in patients with compromised innate immunity. It highlights the differences among the calcium-alginate dressings.

The Critical Need for Standardization in Wound Dressing Evaluation - Woundsource.com
Article by Laura Swoboda. Standardization in wound dressing evaluation is crucial for enhancing patient access to the most clinically appropriate wound dressings at the most affordable price. The author discusses the importance of a standardized set of evaluation criteria to complement clinical evidence gathered in real-world settings, providing a more comprehensive understanding of product effectiveness.

Complications of Hospital-Acquired Wound Infections - Woundsource.com
In this video interview, Dr. Alisha Oropallo describes common complications that can occur with hospital-acquired wound infections, leading to delayed healing, prolonged hospital stays, and more.

Chitosan-Based Dressing Materials for Burn Wound Healing - Mdpi.com
Article by Shiyu Li, Wenlong Pan, Ming Zhang, Kailu Song et al. (Chengdu, China - Polymers). Considering the microenvironment of the burn wound site, the authors summarize the design principles and clinical efficacy of chitosan-based dressings with antimicrobial and/or antioxidative activity.

Bioimpedance Measurement for Monitoring Chronic Wounds: A Systematic Review - PubMed
Abstract by Magdalena Antoszewska, Katarzyna Połomska, Piotr Spychalski, Atte Kekonen et al. (Poland, Finland - Int Wound J.).

Inspirational wound healing - Woundisnternational.com
In this video Laura reflects on her journey in caring for patients with wounds and ostomy, emphasizing the significance of her educational experiences. She discusses the science behind wound healing and its influence on her clinical practice. While optimizing patient health remains a priority, she explores strategies for collaborating with patients to achieve the best outcomes. The role of social determinants of health is examined and how they can be integrated into everyday practice.

The Growing Role of Natural Products in Wound Care and Scar Management - Reachmd.com
The increasing pursuit of effective non-traditional treatment options for wound care is impacting how dermatologists approach scar reduction and tissue repair using natural products.

Vitamin D promotes wound healing in aged skin by modulating inflammation, angiogenesis, and EMT via the Hippo pathway - Sciencedirect.com
Abstract by Yiting Gong, Yurong Ren, Ning Jia, Xiaoming Zhang et al. (Suzhou, China - The Journal of Steroid Biochemistry and Molecular Biology).

Apoptosis and Wound Healing - Numberanalytics.com
Article by Sarah Lee. Apoptosis plays a vital role in wound healing by eliminating damaged cells and promoting tissue regeneration. The complex interplay between apoptosis and other cellular processes highlights the importance of tightly regulating apoptosis during wound healing.

Role of hyaluronic acid in dermal wound healing - Consensus.app
Hyaluronic acid is a key component of the skin’s extracellular matrix and plays a crucial role in all stages of dermal wound healing. It supports cell migration, modulates inflammation, promotes tissue regeneration, and is widely used in advanced wound care products.

Transepidermal water loss may predict wound recurrence for diabetic foot ulcers - Healio.com
Article by Michael Monostra. In a study published in Diabetes Care, researchers measured transepidermal water loss at the center of a diabetic foot ulcer wound 2 weeks after the wound closed. Transepidermal water loss was significantly higher among adults who had wound recurrence at 16 weeks compared with those who did not have their wound reopen.

Exploring the Braden QD Scale Assessment Performance and Related Hospital-Acquired Pressure Injury Influencing Factors among Critically Ill Adult Patients - Lww.com
Article by Xiuli Zhu, Linhe Yang, Junjie Ning, Baoqin Li et al. (China - Advances in Skin & Wound Care). The incidence of hospital-acquired pressure injuries (HAPIs) in critically ill adult patients is high, with several influencing factors. The Braden QD Scale emerges as a validated predictive tool for HAPIs in critically ill adult patients, demonstrating clinical utility that warrants additional investigation to optimize prevention strategies.

Healing Rate and Time to Closure of Venous Leg Ulcers: A Real-World Service Evaluation of Neuromuscular Electrostimulation as an Adjunct to Compression Therapy - Lww.com
Article by Holly Murray, Rochelle Duong and Duncan Shirreffs Bain (Canada, UK - Advances in Skin & Wound Care). Adding neuromuscular electrostimulation of the common peroneal nerve to a care bundle including multicomponent compression resulted in significantly faster wound margin advance and significantly less time to heal in comparison with retrospective matched controls. Future randomized controlled trials or self-controlled studies of this approach would be of great interest to inform clinical practice.

Massive Malignant Transformation in a Patient with Hidradenitis Suppurativa during Anti-Tumor Necrosis Factor Treatment - Lww.com
Article by Gabija Rudzikaitė, Jorinta Jokubaitė, Dominykas Markevičius, Justinas Pamedys and Tasas Raudonis (Vilnius, Lithuania - Advances in Skin & Wound Care). This case highlights the importance of early detection, routine screening, and a multidisciplinary approach in managing the risk of squamous cell carcinoma in patients with hidradenitis suppurativa.

Superbug From Man’s Wound Able to Feed on Hospital Plastic - Cmmonline.com
A recent discovery published in Cell Reports found that a dangerous hospital superbug can digest plastic used in some sutures, stents, surgical mesh, and implants inside the body. The finding challenges the widely held belief that pathogens cannot degrade medical plastics, reports Brunel University of London.

Can Protective Colostomy Have a Role in Pressure Injury Management? A Prospective Non-Randomised Controlled Study - Wiley.com
Article by Andrea Scotti, Franz Wilhelm Baruffaldi Preis, Marco Borrini, Vito Russo and Simona Lavolpicella (Milan, Italy - International Wound Journal). Protective colostomy may prevent local complications after surgery, reducing long-term hospitalization and healthcare costs. It also may improve individuals’ quality of life.

Machine Learning Insights Into Amputation Risk: Evaluating Wound Classification Systems in Diabetic Foot Ulcers - Wiley.com
Article by Farideh Mostafavi, Mohammad Reza Amini, Yadollah Mehrabi, Ensieh Nasli Esfahani and Seyed Saeed Hashemi Nazari (Tehran, Iran - International Wound Journal). This study compares the performance of various wound classification systems to determine which system most effectively predicts amputation risk in diabetic foot ulcer patients.

Quick Guide: Skin substitutes for the management of hard-to-heal wounds - Woundsinternational.com
Skin substitutes offer an increasingly important resource for managing complex wounds and have become a commonplace tool within wound care. The term ‘skin substitutes’ is an umbrella term for the wide range of biological dressings and biological matrices, which facilitate the repair and/or regeneration of the skin through various mechanisms.

The Impact of the Skin Microbiome and Oxidative Stress on the Initiation and Development of Cutaneous Chronic Wounds - Mdpi.com
Article by Manuela Martins-Green, Jane Kim and Klara Aziz (Riverside, USA - Antioxidants). Because of the complexity involved in the initiation and development of these wounds, in order to treat them, it is necessary to ensure that the patients are healthy and that the microenvironment in the wound is conducive to healing while being unfavorable to the growth and establishment of pathogens.

Study could change the definition of wound closure in diabetes care - Msn.com
In patients with diabetic foot ulcers that looked healed and met the current definition of a closed wound, closed ulcers with functionally defective skin that lost more body water were likely to re-open, according to a new National Institutes of Health (NIH) Diabetic Foot Consortium study, led by researchers at the University of Pittsburgh.

Wound Healing Complication in Radio-Treated Limb Soft Tissue Sarcoma Patients: A Single Referral Centre Experience - Wiley.com
Article by Silvia Dal Pos, Marcodomenico Mazza, Carlo Maria Gianesini, Francesco Cavallin et al. (Padua, Italy - International Wound Journal). The use of negative pressure therapy can play a key role in the prevention of wound complications in oncological patients.

The Prevalence and Surveillance of Surgical Site Infections in South Africa: A Literature Review - Wiley.com
Article by Emmy Ngoakoana Nokaneng and Samantha L. Holloway (South Africa, UK - International Wound Journal). There is an urgent necessity to establish an integrated national surveillance programme to facilitate monitoring as well as prevention of surgical site infection in South Africa.

The Development and Evaluation of a Protocol-Based Video Education Program on Medical Device-Related Pressure Injury Prevention for Nurses in Comprehensive Nursing Care Unit - Wiley.com
Article by Mihyun Yoo, Hanna Lee and Jeongwon Han (Korea - International Wound Journal). The protocol-based video education program effectively improved nurses' knowledge of medical device-related pressure injuries prevention and demonstrated its potential as a repeatable and accessible learning tool.

Integral Debridement in the Postoperative Setting: An Expert’s Perspective - Woundsource.com
Article by Abigail E. Chaffin. Integral debridement is an advanced approach to wound bed preparation that involves the synergistic use of multiple debridement techniques to optimize wound healing. Learn more about how this strategy can be applied in the postoperative setting.

Important Terms to Know: Integral Debridement - Woundsource.com
Explore terms to help guide your learning about integral debridement, a comprehensive, evidence-based strategy that combines multiple debridement modalities based on the wound’s unique characteristics, the patient’s comorbidities and treatment tolerance, and the clinical setting.

Exosomes: A Promising Cell-Free Therapeutic Tool for Treating Cutaneous Nerve Injuries and Promoting Wound Healing - Mdpi.com
Article by Yujie Mu, Ruting Luo, Le Zhao, Danting Chen et al. (China - IJMS). Exosomes may aid in treating cutaneous nerve injuries by directly or indirectly promoting axon regeneration, nerve cell proliferation, and the release of protective neurofactors.

Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance - Mdpi.com
Article by Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, George Dan Mogoşanu, Marius Rădulescu et al. (Romania - Gels). The authors' results provide valuable insights into the potential clinical applications of metal-ion cross-linked biopolymeric hydrogel dressings for next-generation wound care strategies.

A Clinical Decision Support Tool for the Management of Diabetes-Related Foot Ulcers (DRFUs) Using a Topical Haemoglobin Spray - Wiley.com
Article by Jose Luis Lazaro-Martinez, David G Armstrong, Paul Chadwick, Andrea Gledhill et al. (Int Wound J.). This article incorporates a clinical decision support tool to help clinicians identify the most appropriate individuals for whom topical haemoglobin may be most beneficial and the most appropriate time for introducing the intervention to improve wound healing outcomes.

Impact of digital wound care solution on healing time: A descriptive study in home health settings - Plos.org
Article by Heba Tallah Mohammed, Robert D. J. Fraser and Amy Cassata (Canada - Plos Digital Health). Continuous digital wound care solutions use significantly reduces healing times and improves wound area reduction, underscoring its effectiveness in enhancing wound care outcomes in HH settings.

Study could change the definition of wound closure in diabetes care - News-medical.net
In patients with diabetic foot ulcers that looked healed and met the current definition of a closed wound, closed ulcers with functionally defective skin that lost more body water were likely to re-open, according to a new National Institutes of Health (NIH) Diabetic Foot Consortium study, led by researchers at the University of Pittsburgh and published today in Diabetes Care.