Hungarian Wound Care Society

Recent Advancements in Chitosan-Based Biomaterials for Wound Healing - Mdpi.com
Article by Jahnavi Shah, Dhruv Patel, Dnyaneshwari Rananavare, Dev Hudson et al. (Piscataway, USA - JFB). The use of chitosan in wound care products is forecasted to drive the growth of the global chitosan market, which is expected to increase by approximately 14.3% within the next decade. This growth is driven by products such as chitoderm-containing ointments, which provide scaffolding for skin cell regeneration. Despite significant advancements, there remains a critical gap in translating chitosan-based biomaterials from research to clinical applications.

Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract - Plos.org
Article by Shohag Chandra Das, Subrato Biswas, Olin Khan, Rupa Akter et al. (Bangladesh - Plos One). Histopathological examination confirmed accelerated wound healing, showcasing reduced inflammation, restored blood vessels, collagen fibers, and swift epidermal closure. T. cordifolia extract exhibits promise in enhancing wound healing through its antibacterial, anti-inflammatory properties.

Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing - Biomedcentral.com
Article by Dan Xia, Ying Guo, Ruodan Xu and Ning Li (China - Journal of Nanobiotechnology). This review summarizes recent advances of nanodressings incorporating NO donors in the treatment of diabetic wounds, detailing the specific conditions under which these nanodressings facilitate NO release, with a focus on the beneficial effects of NO, strategies for its supplementation, and the challenges encountered in the clinical translation of NO donors as a clinically viable nanomedicine in the context of improving diabetic wound healing.

Understanding Inflammatory Stage Stall - Woundsource.com
In this interview, Mary Anne R. Obst discusses the stages of wound healing and why the inflammatory stage can be a point where progress may stall.

Factors associated with the recurrence of foot ulcers in Japanese patients with diabetes - PubMed
Abstract by Kou Ino, Yuji Tajiri, Hisashi Migita, Keigo Morinaga et al. (Kurume, Japan - Diabetol Int.).

Adipose-derived Stem Cells and Wound Healing Are Progressively Impaired Long-term After Radiotherapy in Mice - Lww.com
Article by Kayo Yoshizumi, Natsumi Saito, Yunyan Wu, Takao Shirado et al. (Tochigi, Japan - Plastic & Reconstructive Surgery-Global Open). After 6 months postirradiation, the number of ASCs continued to decline over time, accompanied by irreversible progression of fibrosis, atrophy, and ischemia, which resulted in impaired wound healing.

Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy. The SUNRRISE Randomized Clinical Trial - Jamanetwork.com
Routine application of iNPWT to the closed surgical wound after emergency laparotomy did not prevent SSI more than other dressings.

Advancements in Wound Bed Preparation of Chronic Wounds - PubMed
Abstract by Natalie Hickerson, Thao Kimmy Lam, Robert Kirsner and Hadar Lev-Tov (Miami, USA - Surg Technol Int.).

Impact of phytochemical-based hydrocolloid dressings on wound healing: A comparative review - Jomped.org
Article by Sipho Sibanda, Mapula Razwinani and Keolebogile Shirley Motaung (Durban, South Africa - Journal of Medical Plants for Economic Development). The data analysis revealed that there are few research studies on plant-based hydrocolloids, and there is a need for further research in the area. In addition, the dressings significantly expedite wound healing offering a multifaceted approach because of the different mechanisms of action including antioxidant, anti-inflammatory and cell proliferation.

How Does Nutrition Affect Wound Healing and Patient Recovery - Medium.com
Article by Nabil Ebraheim (Toledo, USA). Orthopedic recovery relies on the interplay of nutrition, blood supply, and immune function. Using tools like the Short Form Nutritional Assessment Survey and monitoring key parameters, healthcare providers can identify and address malnutrition, ensuring better outcomes. Nutrition is not just a supporting factor — it’s a critical part of the healing equation.

Wound Healing in Butterfly Pupal Wing Tissues: Real-Time In Vivo Imaging of Long-Range Cell Migration, Cluster Formation, and Calcium Oscillations - Mdpi.com
Article by Shuka Nagai and Joji M. Otaki (Japan - Insects). The authors' results suggest that cell migration, cluster formation, and calcium oscillations play important roles in wound healing and scale development at and near the damage site.

Implementation of a Hands-On Skin Assessment Simulation as Part of a Hospital-Wide Pressure Injury Prevention Program in a Pediatric Hospital - Woundsource.com
Article by Elizabeth Day Dechant. How might a skin assessment simulation help to prevent pressure injuries in pediatric patients? The author outlines her recent investigation and the resulting insights.

Recognizing the Signs and Symptoms of Wound Infection - Woundsource.com
In this interview, Dot Weir explains why early detection is key in treating wound infections and getting wounds back on the path to healing.

Efficacy of wound care ointment in healing infectious wounds after anorectal surgery: A randomized controlled trial - Lww.com
Article by Lelai Yu, Yinfu Lei and Ke Yuan (Sichuan, China - Medicine). The bismuth subgallate-borneol compound ointment, when used as an adjuvant to standard wound care protocols, demonstrates significant efficacy in treating post-anorectal surgery infectious wounds. Its dual-active component formulation appears to effectively promote both granulation tissue formation and wound healing, potentially through its documented antibacterial properties.

Wound Healing at a Smaller Scale: Study Reveals for the First Time That Membrane Tension Regulates Cellular Repair - Idw-online.de
Similar to a small cut that heals itself after a short time, individual cells in our body suffer “wounds” in their protective layer, the cell membrane, every day and have to repair them again. Researchers at the University of Münster have now identified the processes that enable the precise closure of such membrane injuries.

Hyperbaric Oxygen HBO Therapy Treatment and Wound Healing Effectiveness - Thewoundpros.com
Ever thought about turbocharging your body's built-in healing prowess? Especially for those persistent wounds? Well, Hyperbaric Oxygen Therapy (HBO) does just that! This therapy uses 100% oxygen, amplified by Henry's Law, a principle backed by physics, to increase oxygen solubility in your blood. With this enhanced oxygen supply, cell growth gets pushed, healing genes shift into high gear, and harmful bacteria get kicked out. For difficult conditions like wounds from diabetes, HBO therapy is akin to deploying an elite unit to speed up recovery.

Pressure injury prevention: An educational framework to improve action planning - PubMed
Abstract by Patricia Giuffrida, Anna L Thomas, Heather H David, Shannon Davila and Loretta D Morgan (Nursing).

Utilizing Image Processing Techniques for Wound Management and Evaluation in Clinical Practice: Establishing the Feasibility of Implementing Artificial Intelligence in Routine Wound Care - Lww.com
Article by Mai Dabas, Suzanne Kapp and Amit Gefen (Israel, Belgium - Advances in Skin & Wound Care). Accurate determination of wound size and healing supports decision-making regarding treatment and is essential to successful outcomes. This innovative approach for visual assessment of chronic wounds highlights the potential of computerized wound analysis in clinical practice. By leveraging advanced computational techniques, healthcare providers can gain valuable insights into wound progression, enabling more accurate assessments to support their decision-making.

Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel - Biomedcentral.com
Article by Haonan Wang, Yingnan Xiao, Deli Zhuge, Genghe Shi et al. (China - Journal of Nanobiotechnology). The nanoparticle-hydrogel superstructure shows promise for treating local pathogen-infected wounds.

Nurses' Clinical Decision-Making About Pressure Injury Prevention in Hospital Settings: A Scoping Review - PubMed
Abstract by Joanne Cordina, Kaye Rolls and Jenny Sim (Australia - J Adv Nurs.).

Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs - Nature.com
Article by Jürgen Eichler, Björn Rulik, Alexander Abazid and Matthias B. Stope (Germany - Scientific Reports). This wildlife clinical trial demonstrates that NIPP can be used to improve wound healing in wild European hedgehogs,

Connecting Wound Bed Preparation 2024, Therapeutic Index, and Covert and Overt Infection - Lww.com
Article by R. Gary Sibbald and John H. Gregory (Canada - Advances in Skin & Wound Care). Topical antiseptics with a higher therapeutic index offer greater safety and clinical effectiveness. Further, WBP 2024 also provides an opportunity to link education to improved patient outcomes and healthcare system change.

Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review - PubMed
Abstract by Siem A Willems, Jelle A Nieuwstraten, Abbey Schepers, Jan van Schaik et al. (Leiden, The Netherlands - Vasc Med.).

Top ten tips: preventing pressure injuries in paediatric patients - Woundsinternational.com
Article by Ann Marie Nie. Preventing PI in the paediatric population requires diligence and critical thinking skills. The success of prevention is dependent upon the bedside clinician paying close attention to the application of medical devices and the developmental age of the child they are caring. Success can be achieved with an interdisciplinary team focusing on PI prevention.

Using a single-use, canister-free negative pressure wound therapy on recalcitrant wounds: a case report series - Woundsinternational.com
Article by Marcus Gerlee and Christina Håbber. In conclusion, sNPWT is a highly promising wound-healing modality that offers several benefits compared to conventional NPWT. By improving workflow, enhancing hygiene, reducing the risk of complications and providing cost-effective wound care, the system can improve patient outcomes and support the delivery of efficient and cost-effective healthcare. Further studies are needed to evaluate efficacy, safety and long-term outcomes with the use of VivereX in similar cases.

Systemic factors associated with antler growth promote complete wound healing - Nature.com
Article by Qianqian Guo, Guokun Zhang, Jing Ren, Jiping Li et al. (Jilin, China - npj regenerative medicine). The authors believe that, ultimately, incorporating systemic factors into advanced wound care modalities could offer new opportunities for regenerative healing in the clinical setting.

Understanding the Illness Trajectory of Patients with Venous Leg Ulcers - Woundsource.com
Article by Jennifer J. Spector. Venous leg ulcers (VLU) are a chronic condition often marked by complex comorbidity and self-care considerations. Learn why person-centered care, emphasizing the patient's perspective, is essential in this summary of a recent study exploring the needs and challenges faces by VLU patients.

Multiple Chronic Wounds in an Immunocompetent Patient With Severe Major Depressive Disorder: A Case Report - Cureus.com
Article by Jennifer Emmanuel Tito, Rekha Kalyani, Fatima Halilu, Lavet Tita and Ines Kafando (Baltimore, USA). This case report describes a 38-year-old immunocompetent woman who presented with multiple complex chronic wounds. The patient was admitted to the medical wards and subsequently diagnosed with severe major depressive disorder. Factors contributing to depression in individuals with chronic wounds are not well understood.

Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth - Mdpi.com
Article by Norah A. AlJunaydil, Rhodanne Nicole A. Lambarte, Terrence S. Sumague, Osama G. Alghamdi and Abdurahman A. Niazy (Saudi Arabia - IJMS). The combination of lovastatin 0.1 μM and resveratrol 0.1 μM synergistically improved wound healing and demonstrated an additive effect against S. aureus and P. aeruginosa, presenting potential antibacterial applications.

Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review - Biomedcentral.com
Article by Shulin Hou, Zeyao Shi, Xiaowen Li, Ru Yang et al. (Chengdu, China - BMC Pediatrics). NPWT combined with new wound dressings can effectively manage ruptured giant omphalocele.

Abdominal wound dehiscence after appendectomy during pregnancy treated by negative pressure wound therapy with subsequent vaginal delivery: A case report and literature review - PubMed
Abstract by Jan Zapletal, Borek Sehnal, Radim Dvorak, Miroslav Drienko et al. (Prague, Czech Republic - Int J Gynaecol Obstet.).

Enhancing Clinical Assessment of Skin Ulcers with Automated and Objective Convolutional Neural Network-Based Segmentation and 3D Analysis - Mdpi.com
Article by Rosanna Cavazzana, Angelo Faccia, Aurora Cavallaro, Marco Giuranno et al. (Italy - Applied Sciences). The developed system aims to equip specialists and healthcare providers with an objective tool for assessing and monitoring skin ulcers. An interactive graphical interface, implemented in Unity3D, allows healthcare operators to interact with the system and visualize the extracted parameters of the ulcer.

Perch Hydrolysates from Upcycling of Perch Side Streams Accelerate Wound Healing by Enhancing Fibroblasts to Secrete Procollagen I, Fibronectin, and Hyaluronan - Mdpi.com
Article by Jia-Feng Chang, Chih-Yu Hsieh, Ling-Ni Chen, Mao-Hsiang Lee et al. (Taiwan - CIMB). The residue of perch extract can be upcycled via a hydrolysis technique to produce not only bioactive sequences but also short-chain peptides. Considering the therapeutic potential to promote wound healing, such by-products are of great value and may be developed as dietary nutraceuticals.

Aligned membranes regulate wound healing via MMP12 secreted by macrophages - Plos.org
Article by Hongli Ma, Limin Gong, Xi Yang, Hui Fang et al. (Hefei, China - Plosone). The authors' findings reveal that Align effectively enhances skin wound healing by upregulating MMP12 expression while inhibiting fibroblast migration. These insights provide valuable knowledge on how Align promotes efficient scar-free wound healing and serve as a theoretical foundation for developing more effective biological dressings.

Zinc Oxide Nanoparticle Loaded L-Carnosine Biofunctionalized Polyacrylonitrile Nanofibrous Wound Dressing for Post-Surgical Treatment of Melanoma - Mdpi.com
Article by Shahin Homaeigohar, Danial Kordbacheh, Sourav Banerjee, Jiacheng Gu et al. (Dundee, UK - Polymers). ZCPAN nanofibers induce an antimelanoma effect through oxidative stress and thus are a high potential wound dressing material to suppress melanoma regrowth after surgical excision of skin tumors.

Incidence of seroma and postoperative complications after breast surgery before and during the Covid-19 pandemic: results from a retrospective multicenter analysis - Biomedcentral.com
Article by Maximilian Heinz Beck, Izabela A. Brachaczek, Pimrapat Gebert, Jens-Uwe Blohmer et al. (Germany - BMC Cancer). While the authors' findings did not indicate an elevated incidence of seroma during the SARS-CoV-2 pandemic, they observed increased rates of erythema, wound healing disorders, and wound infection. Additional real-world evidence is needed for understanding both early and late complications following breast surgery in the context of the ongoing SARS-CoV-2 endemic.

New Study Sheds Light on Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers - Woundsource.com
Article by Jennifer J. Spector. In a prospective, randomized, controlled trial including 60 adult patients, researchers evaluated outcomes of DFU treatment with hyperbaric oxygen therapy combined with standard wound care against standard wound care alone.

Breaking Down the Stages of Biofilm Formation - Woundsource.com
Article by Jennifer J. Spector. Biofilm is a common complication found in hard-to-heal wounds. In this blog, learn the stages of biofilm formation and what this means for wound healing.

Effectiveness of negative pressure wound therapy in treating deep surgical site infections after spine surgery: a meta-analysis of single-arm studies - Springer.com
Article by Shiwei Ren, Huan Liu and Zhengqi Chang (Shandong, China - Journal of Orthopaedic Surgery and Research). Available evidence supports the effectiveness of NPWT in treating deep SSIs following spinal surgery, suggesting its clinical utility. However, further studies are needed to compare NPWT with other treatment options for SSIs management.

Application of Clinician Support Tools to Improve Wound Healing Outcomes and Simplify Treatment Selection for Effective Exudate Management - Hmpgloballearningnetwork.com
Article by Amanda Loney, Britney Butt and Sophie Berry (Canada, UK - Wounds). Adopting wound management decision tools has the potential to ease the increasing burden of wound care to health care systems, patients, and society.

Unlocking Excellence: Improving Nursing Students' Knowledge of Pressure Injury Prevention through an Escape Room Experience - PubMed
Abstract by Tuba Sengul and Nurten Kaya (Istanbul, Turkey - Adv Skin Wound Care).

Bagging an Extremity for Negative-Pressure Wound Therapy: A Case Report - PubMed
Abstract by Krešimir Bulić and Lucija Gatin (Zagreb, Croatia - Adv Skin Wound Care).

Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration - Mdpi.com
Article by Gloria Huerta-Ángeles and Edgar Mixcoha (Czech Republic, Mexico - Applied Sciences). This review focuses on products containing HA, novel developments, gaps, and limitations of the current state of the art.

Delayed cutaneous wound healing in young and old female mice is associated with differential growth factor release but not inflammatory cytokine secretion - Springer.com
Article by Melissa Plum, Justus P. Beier and Tim Ruhl (Aachen, Germany - Biogerontology). The present study suggests that a reduced regenerative capacity rather than an enhanced inflammatory score affected the tissue regeneration process in old mice.

A Case of Euglycemic Diabetic Ketoacidosis in a Patient with Diabetic Foot Syndrome - Sagepub.com
Abstract by Massimo Giambalvo, Francesco Giangreco, Elisabetta Iacopi, Letizia Pieruzzi et al. (Pisa, Italy - The International Journal of Lower Extremity Wounds).

Patient and wound factors associated with WOUND-Q scales measuring health-related quality of life: An international cross-sectional study - Wiley.com
Article by Nina Vestergaard Simonsen, Sören Möller, Charlene Rae, Anne F. Klassen, et al. (Denmark, Canada, USA - Wound Repair and Regeneration). This study identified factors affecting health-related quality of life in individuals with chronic wounds.

Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review - Wiley.com
Article by Anna S. van den Bosch, Robin A. F. Verwilligen, Anouk Pijpe, Lex B. Jansen et al. (The Netherlands - Wound Repair and Regeneration). This is the first review to address the indications for dermal substitutes in burn patients, providing valuable insights for the development of international evidence-based treatment guidelines.

Advancements in Hyaluronic Acid Effect in Alveolar Ridge Preservation: A Narrative Review - Mdpi.com
Article by Paul Andrei Nistor, Andreea Cândea, Iulia Cristina Micu, Andrada Soancă et al. (Cluj-Napoca, Romania - Diagnostics). The addition of hyaluronic acid to bone grafts may enhance some ARP outcomes. However, the variability in outcomes and methodologies across the evaluated studies precludes drawing definitive clinical conclusions.

Efficacy of Larval Therapy for Wounds: A Systematic Review and Meta-Analysis - Mdpi.com
Article by Thao Lam, Gabriela E. Beraja and Hadar Lev-Tov (Miami, USA - JCM). Larval therapy (LT) is as effective as conventional therapy for debridement and may be an alternative for patients who cannot tolerate traditional methods. LT patients may experience similar levels of pain, but LT does not worsen wound healing or infection compared to those receiving routine care.

Natural products in the treatment of diabetic foot infection - Biomedcentral.com
Article by Mohsen Nazari, Leili Shokoohizadeh and Mohammad Taheri (Hamadan, Iran - European Journal of Medical Research). The authors' findings suggest that natural products could play a crucial role in developing sustainable and effective treatment strategies for DFIs, especially in the face of rising antimicrobial resistance.

Innovations Aiming to Overcome DFU Obstacles - Woundsource.com
Learn more from these innovation insights presented by researchers at the recent Great Debates and Updates in Diabetic Foot.

Emerging Limb Salvage Research Pearls - Woundsource.com
These recent limb salvage abstracts from Great Debates and Updates in the Diabetic Foot shed light on researchers' work related to diabetic foot ulcers.

Additional Research Insights on Diabetic Wound Healing - Woundsource.com
These recently presented abstracts could shed some light on key topics in diabetic wound healing in your practice.

Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration - Nature.com
Article by Zihan Li, Chuwei Zhang, Lei Wang, Qingrong Zhang, et al. (Nantong, China - Scientific Reports). Chitooligosaccharides, intermediate products of chitosan degradation, have shown efficacy in promoting tissue repair, yet their role in diabetic wound healing remains underexplored.

Hydrogel Dressings Accelerating Diabetic Wound Healing - Technologynetworks.com
Article by Andy Tay. Compromised vessel networks and persistent inflammation in diabetic wounds prevent transport to and from wound sites, disrupting wound healing.

Challenges of Porcine Wound Models: A Review - Mdpi.com
Article by Margarita Elloso, Maria Fernanda Hutter, Nicklas Jeschke, Graham Rix et al. (Hamilton, Canada - IJTM). In this review authors discuss the various challenges of the model. Investigators using pig models should be well informed of the challenges of the porcine wound model to prevent possible problems and complications.

Leveraging Microneedles for Raised Scar Management - Mdpi.com
Article by Zhengyun Jin, Young-Seong Kim and Joong Yeon Lim (Seoul, Republic of Korea - Polymers). By penetrating scar tissue, microneedles facilitate controlled and sustained localized drug administration to modulate inflammation and fibroblastic cell growth.

Beneficial Effects of Tilapia Fish Skin on Excisional Skin Wound Healing in a Type I Diabetic Rat Model - Wiley.com
Article by Omar Hussein Hosny, Khaled Radad, Magda Mahmoud Ali and Ahmed Fathy Ahmed (Assiut, Egypt - J Biomed Mater Res B Appl Biomater.). Fresh Tilapia skin proved to be a safe and effective dressing for promoting wound healing and managing infection in diabetic wounds.

Successful Treatment of Chronic Wound in a Patient with Longstanding Shell Injury on Heel using, a Novel Product Formulation: A Case Report - Jocr.co.in
Article by Gaurav Bhardwaj, Ramit Dhalla and Imola Jamir (Chandigarh, India - Journal of Orthopaedic Case Reports). The management of non-healing chronic wounds poses major challenges in clinical practice. This novel formulation may offer a potential solution for patients with chronic wounds.

Electrospun Nanofibers from Plant Natural Products: A New Approach Toward Efficient Wound Healing - Tandfonline.com
Article by Qin Liu,Shicui Luo,Junjie Peng and Renjie Chang (Kunming, China - International Journal of Nanomedicine). This article reviews the application of plant natural product nanofibers prepared by electrospinning technology in wound healing, focussing on the development and optimisation of these nanofibers, discussing the advantages and challenges of using plant natural products in this technology, and outlining future research directions and application prospects in this field.

Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease - Mdpi.com
Article by Yi Xue, Tao Wang, Ji-Peng Liu, Qi Chen et al. (China - Antioxidants). The authors review the latest research and advancements in nano-antioxidants for skin-related diseases. They categorize skin-related diseases into four main groups: skin inflammatory diseases, skin damage caused by ultraviolet rays, skin wound healing, and other skin-related conditions.