Hungarian Wound Care Society

Hair follicle inspired therapies for wound healing and scar remodelling - Jprasurg.com
Article by Min Waye Chewa, Summik Limbua, Paul Kempb and Claire A Higgins (UK - International Journal of Surgical Reconstruction). In this review, authors discuss the role of hair follicles, and cells or biomaterials derived from the hair follicle, in both wound healing and scar remodelling.

Risk factors for delayed wound healing after anal fistula surgery: Protocol of a meta-analytic study - Nih.gov
Article by Zubing Mei, Peixin Du, Ye Han, Yin Qu, Huili Tang et al. (Shanghai, China - PLoS One). This study aims to identify and evaluate risk factors associated with delayed wound healing after anal fistula surgery by combining existing evidence and grading the evidence.

Hydrogels Modulating the Microbiome: Therapies for Tissue Regeneration with Infection Control - Mdpi.com
Article by Germán Reynaldo Jiménez-Gastelum, Carlos Esteban Villegas-Mercado, Juan Luis Cota-Quintero, Silvia Ivonne Arzola-Rodríguez et al. (Culiacan, Mexico - Gels). This review explores the emerging role of functionalized hydrogels in modulating the microbiome for therapeutic applications in tissue regeneration and infection control.

D-Tryptophan Promotes Skin Wound Healing via Extracellular Matrix Remodeling in Normal and Diabetic Models - Mdpi.com
Article by Dawit Adisu Tadese, James Mwangi, Brenda B. Michira, Yi Wang et al. (China - IJMS). The authors' findings suggest that D-Trp promotes healing by boosting ECM turnover, reducing inflammation, and activating MAPK/JAK pathways. Thus, D-Trp is a promising therapeutic for diabetic wounds.

The Effectivity MultiModality Treatment on Rehabilitation Management of Diabetic Foot Disease Patients for Improvement of Clinical Efficacy & Hemorheological Status - Dovepress.com
Article by Shuo Li, Yan Liu and Yu Chen (Qingdao, China - Diabetes, Metabolic Syndrome and Obesity). Compared with routine nursing care alone, the multimodal intervention strategy may improve clinical efficacy, hemorheology, endothelial function, self-management capabilities, and patient satisfaction in diabetic foot care. However, these findings should be interpreted with caution given the retrospective design.

Accelerated wound healing with topical formulation based on Lobularia maritima essential oil: A rat model study - Sciencedirect.com
Article by Boutheina Ben Akacha, Asma Mahmoudi, Miroslava Kačániová, Wirginia Kukula-Koch et al. (Tunisia, Poland - Fitoterapia). The authors' findings showed that this EO contributed to the healing process by creating scars with high tensile strength and accelerated wound closure through stimulating collagen deposition. The findings also revealed that L. maritima essential oil had a role in the healing process by promoting fibroblast migration to the wound site, which resulted in collagen formation.

Global, regional, and national trends in decubitus ulcer burden from 1990 to 2021 and forecasts to 2040 - PubMed
Abstract by Ruijuan Li, Xueneng Yang, Hanbo Chen, Minglin Dong et al. (Kunming, China - Front Public Health).

From Sea to Therapy: Marine Biomaterials for Drug Delivery and Wound Healing - Mdpi.com
Article by Mansi Chilwant, Valentina Paganini, Mariacristina Di Gangi,Sofia Gisella Brignone et al. (Pisa, Italy - Pharmaceuticals). This review aims to provide a multidisciplinary perspective for researchers and industrial stakeholders seeking sustainable and multifunctional pharmaceutical platforms for precision medicine and regenerative therapeutics.

The Role of Infection in Delayed Wound Healing: Insights into Chronic Wound Pathogenesis and Treatment Approaches - Ssrn.com
Article by Anwar A. Algaber and Saif Y. Hasan (Iraq). This report highlights the importance of early infection control, rigorous wound monitoring, and individualized treatment protocols in preventing chronicity. Understanding infection's role in wound pathogenesis is essential for developing more effective therapeutic approaches, ultimately improving patient outcomes in both surgical and non-surgical settings.

Wound Healing Activity: A Comprehensive Review - Ijrpr.com
Article by Abhishek Singh, Ruchi Khare Shrivastava, Ranu Yadav, Raghvendra Dubey and Hemant Swami (India - International Journal of Research Publication and Reviews). The authors' review touches upon current therapeutic interventions aimed at enhancing wound healing outcomes. These include both conventional topical agents and herbal formulations, with specific attention given to their bioactive constituents and mechanisms of action in modulating the wound healing cascade.

Psychological Stress Impairs Wound Healing and Collagen Production, New Review Confirms - Dermatologytimes.com
Article by Marie Bosslett. A new review has analyzed how psychological stress may impact proper wound care and healing. Prior research has already confirmed that stress disrupts cytokine signaling, immune cell function, and fibroblast activity, thus impacting all phases of wound healing. However, this new literature reveals that chronic stress also impairs collagen production, making scar treatments less effective.

Potential Use of Cefiderocol and Nanosilver in Wound Dressings to Control Multidrug-Resistant Gram-Negative Bacteria - Mdpi.com
Article by Żaneta Binert-Kusztal, Agata Krakowska, Iwona Skiba-Kurek, Magdalena Luty-Błocho et al. (Poland - Molecules). The authors' findings highlight the importance of agent selection, concentration, and formulation in designing effective antimicrobial wound dressings. They also suggest that further research is needed to optimize such combination therapies for clinical use.

Machine Learning in Predicting Wound Healing and Limb Salvage Outcomes Following Lower Limb Revascularization: A Systematic Review of Prognostic Accuracy - Cureus.com
Article by Abdulkreem Al-Juhani, Rodan Desoky, Abdullah Abdullah, Elsayed Younes et al. (Saudi-Arabia). Machine learning models exhibit significant predictive capability in forecasting wound healing and limb salvage results following revascularization, frequently surpassing conventional clinical instruments.

New insights into the immune system’s crucial role in wound healing revealed - Manchaster.ac.uk
An enzyme expressed by skin cells could be helpful in the management of non-healing skin wounds and ulcers, according to research by University of Manchester and Singapore’s A*STAR Skin Research Lab scientists.

Wound healing properties and antibiofilm activity of hydrogel matrix containing nitric oxide, silver nanoparticles, and ciprofloxacin against Pseudomonas aeruginosa burn wound infection - Nature.com
Article by Zahra Chegini, Mehdi Azizi, Maliheh Safaiee, Fereshte Kalhori, Raha Zare Shahraki et al. (Hamadan, Iran - Scientific Reports). Hy-NO-Ag-Cip enhances antibiotic accumulation at the infection site through a controlled drug release, resulting in a substantial antibacterial action and improved wound healing.

Common amino acid found to speed up skin wound healing - Newatlas.com
Article by Paul McClure. When the skin is injured, a stem cell’s survival instincts kick in. New research reveals that a simple amino acid, serine, helps push stem cells to abandon hair growth in favor of wound healing, opening the door to new therapies for chronic wounds.

Scientists Create a ‘Smart Sponge’ That Knows When to Heal and When to Fight Inflammation - Zmescience.com
Article by Mihai Andrei. Normally, the immune system kicks off an inflammatory response to clean up damaged tissue and fight off infection. After that, it transitions to a healing phase. But in chronic wounds, this transition never happens. The immune system remains constantly active, even when the original threat is gone, fueling a cycle that prevents the wound from healing.

Surgical Site Infection Following Dermatologic and Plastic Surgery in an Office Setting - Cureus.com
Article by Daichi Morioka, Satoru Tamura, Takaharu Otsuka, Sayo Tatsuta and Mari Nakahara (Japan). Although a single-center, retrospective study, it included a large sample size with a broad age distribution and representation of various anatomical areas. The incidence of SSIs in this study was extremely low compared with previous studies.

Combined Application of Negative Pressure Wound Therapy and Dermal Substitute for Coverage of a Complex Cutaneous Defect: A Case Report - Cureus.com
Article by Gladys M. Ballesteros Solís, Arym P. Preza Estrada, Harvey Zamora-Veliz, José Luis Villarreal Salgado and Gerardo S. Rea-Martínez (Mexico). This case highlights the importance of using negative pressure therapy as an effective adjuvant in the management of complex acute wounds, allowing for better preparation of the recipient site and facilitating graft integration. It also emphasizes the need for a comprehensive and timely approach to the treatment of abrasion burns, especially in traumatic settings, where prompt intervention can directly influence clinical outcomes and patient quality of life.

Risk factors for pressure injuries in critical care patients: an updated systematic review - Sciencedirect.com
Article by Jenny Alderden, Katie R. Brooks, Susan M. Kennerly, Tracey L. Yap et al. (USA - International Journal of Nursing Studies). The new evidence found in this updated review reinforces previously identified risk factors – age, mobility limitations, poor perfusion, and vasopressor use – while identifying length of stay and diabetes as additional potential contributors to pressure injury risk. Comprehensive risk assessments for critically ill patients should prioritize these factors, especially in older adults with compromised mobility, poor perfusion, or receiving vasopressors.

The Future of Wound Care: Nanotechnology and Stem Cells - Saakhealth.com
Precision, diligence, and creativity have always been required for wound care, particularly for patients with severe or chronic injuries. Even though conventional therapies like dressings and antibiotics have had their use, they frequently fail to hasten healing and lower complications. However, the management of wounds is about to undergo a revolution thanks to the incorporation of cutting-edge technology. Nanotechnology and stem cell therapies, two innovative techniques that have the potential to completely alter the field of wound care, are among the most promising developments.

Efficacy of Vacuum-assisted Wound Closure in Improving Healing in Breast Surgery Patients: A Review - Lww.com
Article by Alexa Clark, James Sherrer, Karina Grover, Orr Shauly et al. (USA - Plastic & Reconstructive Surgery-Global Open). NPWT is a promising alternative to standard-of-care dressings for mitigating postoperative wound healing complications in breast reconstruction, augmentation, and reduction. Limitations of this review include the lack of statistical comparison due to the small number of available studies and the minimal consistency of primary outcomes reported within breast surgery research. Even so, NPWT demonstrates an overall decrease in complications and provides a novel approach to enhancing cosmesis and healing of breast incisions postoperatively.

The Effect of a Class IV Therapeutic LASER on Post-Surgical Wound Healing Processes in Canis familiaris and Felis catus: A Preliminary Study - Mdpi.com
Article by Ana Lopes, Pedro Azevedo and L. Miguel Carreira (Portugal, USA - Animals). The authors' results suggest that class IV laser therapy accelerates post-surgical wound healing by modulating inflammation, enhancing vascularization, and supporting extracellular matrix remodeling. This technique may serve as a valuable adjunct to conventional wound management in veterinary practice. Further studies are needed to confirm these findings and explore long-term outcomes.

Marine bioactive peptides as potential therapeutic agents for wound healing – a review - Tandfonline.com
Article by Kai Zheng, Ziwei Yang and Te Ba (China - Annals of Medicine). In this review, authors integrated and examined the current understanding of wound care. Additionally, they analysed the underlying molecular mechanisms involved to elucidate the characteristics of marine bioactive peptides.

The Effect of Platelet Rich Plasma on Wound Healing in Pressure Ulcer Patient Grade III and IV - Wiley.com
Article by Almahitta Cintami Putri, Hardisiswo Soedjana, Lisa Hasibuan, Ali Sundoro et al. (Bandung, Indonesia - International Wound Journal). The authors concluded PRP injection significantly reduces PUSH scores and increases collagen density compared to the control group. By day 21, no significant differences were observed between PRP injection and topical PRP.

Patient Race and Ethnicity Do Not Predict Ulceration Among Ambulatory Patients With Venous Insufficiency - Wiley.com
Article by Andrew Nicholas, Fernando J. Salinas, Tammy Gonzalez, Katherine Baquerizo Nole et al. (Cincinnati, USA - Wound Repair And Regeneration). While prior studies report greater chronic wound treatment rates among non-White racial minority patients, these findings do not demonstrate differences in ambulatory care for venous ulceration within nationally representative data.

Global, Regional, and National Burden of Pressure Ulcers From 1990 to 2021 and Projections Over the Next Decade: Results From the 2021 GBD Study - Wiley.com
Article by Xiaodong Lan, Yong Tang, Zhenjia Huang, Tao Zhou et al. (China - Wound Repair And Regeneration). Strengthening prevention strategies and improving healthcare access are critical to reducing the global pressure ulcer burden.

A systematic study of emergency strategies for skin healing after pediatric burns: a comprehensive review and a multidisciplinary perspective - Biomedcentral.com
Article by Luigi Coppola, Alessandra Cianflone, Pasquale Primo, Alessandra Macrì et al. (Naples, Italy - Italian Journal of Pediatrics). The authors' study aims to identify areas for improvement and potential advancements in pediatric burn management, suggesting possible future approaches based on Advanced therapy medicinal products (ATMPs) storage approaches.

Early Wound Dressing (soft gauze/tape dressing) Removal after Cesarean Delivery: A Meta-Analysis of Randomized Trials - Sciencedirect.com
Abstract by Leshae A Cenac, Serena Guerra, Alicia Huckaby, Gabriele Saccone and Vincenzo Berghella (USA, Italy - American Journal of Obstetrics & Gynecology MFM).

A Detailed Review on Wound Healing, Wound Assessment, Phases of Wound Healing, Different Evaluation Model for Wounds and Skin Disorder - Ijpsjournal.com
Article by Prajakta Randive, K. B. Kotade, C. J. Bhangale and S. N. Bhandare (Chincholi, India - Int. J. of Pharmaceutical Sciences). The authors' results showed that both tested materials resolved the surgically created dead space without adverse host responses. This review will contribute to the understanding of wound healing and the development of potential treatments for various types of wounds.

Exploring the Chorioallantoic Membrane (CAM) as a Platform for Burn Wound Modelling and Analysis - Mdpi.com
Article by Rita Araújo, Maria Guerra-Gomes, Joana Barros and Pedro Gomes (Portugal - MPs). The authors' findings support the chorioallantoic membrane as a viable pre-clinical platform for the study of burn wound healing and for the early-stage screening of candidate therapeutic agents.

Reducing dietary serine may help hair follicle stem cells heal skin wounds faster - Medicalxpress.com
The skin has two types of adult stem cells: epidermal and hair follicle. Their jobs seem well-defined: maintaining the skin, or maintaining hair growth. But as research from Rockefeller University has shown, hair follicle stem cells (HFSCs) can switch teams, pitching in to heal the skin when it receives an injury. How do these cells know it's time to pivot?

The Wound Pain Disconnect: Why Some Patients Hurt More Than Others - Woundsource.com
Article by Matthew Davis. Wound pain is personal. When we recognize that pain isn’t just a symptom but a signal shaped by biology, experience, and inflammation, we move closer to truly personalized wound care. And in doing so, we create space not just for healing, but for dignity, trust, and relief.

Nanozymes for Accelerating the Foot Wound Healing: A Review - Dovepress.com
Article by Ke Lv, Shumin Zhang, Zimo Yao, Chao Zhou and Jianda Xu (China - International Journal of Nanomedicine). This review summarizes current knowledge about nanozymes and their potential mechanisms in diabetic wound healing. An overview of progress in the applied research on these nanozymes, current challenges and future perspectives of nanozymes in related fields of diabetic wound healing is also discussed to stimulate new strategies and preclinical translations.

Effectiveness of dietary interventions in individuals with diabetes for preventing and healing chronic wounds; a systematic review with meta-analysis - Wiley.com
Article by Hailey R. Donnelly, Clare E. Collins, Erin D. Clarke, Prudence I. Morrissey et al. (Australia - Diabetic Medicine). There is low-quality evidence that nutrient supplementation improves wound healing. Nutrition education may have a role in enhancing wound size reduction.

Treatment of infected wounds with cold atmospheric plasma: a case series - Magonlinelibrary.com
Abstract by Elia Ricci, Monica Pittarello, Andrea Ricci, Stefanie Ascher and Lisa Gebhardt (Italy, Germany - Journal of Wound Care).

A Recent Insight into Research Pertaining to Collagen-Based Hydrogels as Dressings for Chronic Skin Wounds - Springer.com
Article by Andreea Mariana Negrescu and Anisoara Cimpean (Bucharest, Romania - Gels). This paper discusses the recent advancements in collagen-based hydrogels as wound dressings, thus highlighting their potential as a future therapeutic approach for skin chronic wound care.

A nomogram model for predicting risk factors and the outcome of skin ulcer - Tandfonline.com
Article by Honglin Jia, Yang Tan, Hong Li, Xiaoqing Bu et al. (Annals of Medicine). The prediction nomogram developed in this study exhibits good accuracy in predicting the risk factors of skin ulcers and provides an objective tool for clinical staff to assess and target the risk factors concerning the prognosis of skin ulcers.

Investigating the potential antibacterial, anti-biofilm, wound healing and anti-inflammatory activity of the extract of Aspergillus niger endophyte isolated from cucumber leaves: in vitro and in vivo study - Springer.com
Article by Maisra M. El-Bouseary, Duaa Eliwa, Mahmoud H. Farghali and Amany E. Ragab (Tanta, Egypt - BMC Microbiology). The authors' findings highlight A. niger as a valuable source of natural therapeutics. Additional research is needed to explore its key active components and potential side effects.

New Strategies for the Treatment of Diabetic Foot Ulcers Using Nanoenzymes: Frontline Advances in Anti-Infection, Immune Regulation, and Microenvironment Improvement - Tandfonline.com
Article by Shuyu Jia, Siyu Wu, Min Yi, Ziqi Jiang et al. (Changchun, China - International Journal of Nanomedicine). This article summarizes the role of nanoenzymes in diabetic wound management and discusses the potential mechanisms of their action. Authors also provide an outlook on their application prospects, aiming to advance their clinical utilization.

Insights into advanced dressings based on shape memory materials for wound management - PubMed
Abstract by Tianran Song, Kun Li, Jingxi Wang, Xuemei Sun et al. (Beijing, China - J Mater Chem B.).

Delivering wound care in challenging environments: A mobile health approach for people experiencing homelessness - Wounds-uk.com
Article by Rebecca Morgan. This article discusses the development of a pilot mobile health service within South Wales delivering much needed wound care to people experiencing homelessness (PEH). This initiative aims to improve access to wound care for PEH by delivering services via a mobile clinical unit in partnership with The Wallich, a Welsh homelessness charity. Those experiencing homelessness are susceptible to developing wounds and other skin disorders, with emergency departments often being the chosen route of care for PEH as traditional healthcare settings fail to meet their needs.

Healing takes a team: Why venous surgeons and tissue viability nurses must work together - Wounds-uk.com
Article by Omer Hamza Dinc. Healing VLUs is not a one-person job. It takes time, planning and, above all, collaboration. From a business development point of view, the case is simple. Better communication improves outcomes and reduces costs. But from a human point of view, it is even simpler. Patients deserve continuity, not conflict.

Impact of targeted training on nurses’ awareness of skin tone diversity - Wounds-uk.com
Article by Ruth Ashadzi Salmanu. The role of nurses in pressure ulcer prevention cannot be overemphasised in healthcare. There is insufficient evidence to establish the effect of education on nurses’ awareness of skin tone diversity; however, nurses have a moral and professional duty to ensure culturally competent skin assessments to prevent pressure ulcers, regardless of the patient’s skin tone.

Accelerating infectious wound healing through bacterial cellulose/ag composite film enriched with GM-CSF - Nature.com
Article by Bilin Zhang, Zhifeng Huang, Tian Guo, Jingchen Jing and Yunzhi Dang (Xi’an, China - Scientific Reports). In this work, authors employed BC as a matrix material, silver nanoparticles (Ag) as antibacterial agents, and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a cell growth-promoting factor to enhance the healing of infected chronic wounds.

Ritual, superstition and science in wound healing: Part 1 – the limits of scientific philosophy and the role of faith in evidence-based practice - Wounds-uk.com
Article by Oscar Constantopoulos and Matthew Wynn. Science and superstition are not diametrically opposed; both represent attempts to make sense of the unknown. The real challenge lies in integrating these perspectives in ways that respect cultural values while safeguarding public health and promoting the benefits of rational, evidence-based medicine.

An Overview and Survey of US Food and Drug Administration–Registered Wound Imaging Devices Capable of Determining Percentage Area Reduction and/or Percentage Volume Reduction - Hmpgloballearningnetwork.com
Article by Holly Korzendorfer, Peggy Dotson, Francis James, Windy Cole and Alisha Oropallo (Wounds). More wound imaging devices measure percentage area reduction (PAR) than percentage volume reduction (PVR), and most utilize the perimeter alone or in conjunction with square surface area and/or oval or other shapes for area calculations. While variations in length or width (up to 5%), and area (up to 10%) may occur with the device calculations, these variations are less than is seen with ruler measurements. Several imaging devices incorporate methods to correct for skew, have sophisticated 3-dimensional modeling, and/or use reference markers to enhance overall accuracy and reliability, supporting their measurements as reliable indicators of wound trajectory.

Red yeast rice expedites wound healing in diabetic rats: emphasis on its pro-collagen and angiogenic activities - Springeropen.com
Article by Abdulmohsin J. Alamoudi, Basma G. Eid, Ashraf B. Abdel-Naim and Esam M. Aboubakr (Saudi Arabia, Egypt - Future Journal of Pharmaceutical Sciences). RYR expedites wound healing of diabetic rats. This is at least in part, due to its ability to act as an antioxidant, reduce inflammation, promote collagen production, and support the formation of new blood vessels.

The Impact of Psychological Stress on Wound Healing: Implications for Neocollagenesis and Scar Treatment Efficacy - Dovepress.com
Article by Kali Mochel, Joshua Bronte, Melis Kasaba, Abhinav Vempati et al. (New York, USA - Clinical, Cosmetic and Investigational Dermatology). The authors' findings underscore the importance of integrating stress management into scar treatment protocols and highlight the need for further research into combined physiological and psychological approaches to optimize healing.

Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review - Mdpi.com
Article by Popat Mohite, Abhijeet Puri, Shubham Munde, Nitin Ade et al. (India, Thailand - Pharmaceutics). The review concludes by advocating for further research into optimizing the studied nano-formulations to maximize their potential in clinical settings, thereby improving therapeutic strategies for wound care and regeneration.

Prospective observational study to examine clinical performance and safety of a gelling fiber dressing in routine clinical practice - Woundsinternational.com
Article by Jan Heggeman. This study highlights the effectiveness and safety of a gelling fiber dressing when applied to low- and high-exuding wounds, both acute and chronic, in routine clinical practice.