Hungarian Wound Care Society

The effect of blue and green light on human umbilical cord mesenchymal stem cells for promoting proliferation and wound healing - Nature.com
Article by Zhuojun Shi, Site Li, Wei Chen and Hong Yan (China - Scientific Reports). RNA-Seq confirms the significant roles of blue and green light in inhibiting epithelial-mesenchymal transition and inflammation. In vitro co-culture models and conditioned media experiments validate these anti-inflammatory effects.

Influence of anticoagulant concomitant medication on wound healing: Analysis of a multicentre cohort of 212 patients with a uniform wound model - Wiley.com
Abstract by Christian Seebauer, Fares Hanafieh, Jan Wolff, Hans-Robert Metelmann and Marcus Vollmer (Germany - BJCP).

The Role of Infrasound and Audible Acoustic Sound in Modulating Wound Healing: A Systematic Review - PubMed
Abstract by Aryna C Armand, Matin Bikaran, Timothy B Gardner and Michael K Matthew (USA - Int Wound J.).

Protection with a collagen wound matrix containing polyhexamethylene biguanide supports innate wound healing in biofilm-infected porcine wounds - Wiley.com
Article by Stephen C. Davis, Justin T. Avery, Joel Gil, Michael R. Solis et al. (USA - Wound Repair and Regeneration). Gene expression analysis demonstrated that by reducing bacterial load, wounds progressed through the innate wound healing cascade, while untreated wounds exhibited a dampening of the immune response. Additionally, for randomly assigned wounds, PCMP was not reapplied at dressing changes to assess the impact of inconsistent wound protection.

Diabetic Wound Care: The Importance of Checking Patient’s Toes - Diabetesincontrol.com
Diabetic wound care starts at the toes - literally. A small oversight today can become a major complication tomorrow. For clinicians, checking the feet and especially the toes should be as routine as checking vital signs. With consistent education, thorough inspections, and patient-centered communication, providers can help prevent ulcers, infections, and amputations.

Silk Elastin Gel Shows Promise in Wound Healing - Emjreviews.com
A recent clinical study has highlighted the potential of a novel silk elastin-based sponge, SE-P47K-WAS, as an effective treatment for both acute and chronic wounds. Developed through genetic engineering, this gel-forming biomaterial aims to support wound healing by promoting granulation tissue formation, encouraging angiogenesis, and facilitating epithelialisation.

Nutrition and Wound Healing: Practical Takeaways for Wound Care Practitioners - Woundsource.com
Article by Kirra Fedyszyn. A typical approach to wound healing often includes topical treatments, antimicrobial dressings, or skin substitutes, but these interventions only reach their full potential when paired with optimal nutrition. In a session presented at WoundCon Spring 2025, Nancy Munoz and Mary Litchford discussed the crucial role of proper nutrition in wound healing.

Promising Antimicrobial Activities of Essential Oils and Probiotic Strains on Chronic Wound Bacteria - Mdpi.com
Article by Mara-Mădălina Mihai, Beatrice Bălăceanu-Gurău, Alina Maria Holban, Cornelia-Ioana Ilie et al. (Bucharest, Romania - Biomedicines). Essential oils and probiotic strains demonstrate promising antimicrobial effects against chronic wound pathogens and may serve as alternative or adjunctive treatments to antibiotics. Further clinical research and standardization are necessary to establish their safety, efficacy, and optimal application protocols.

In Vitro Effects of Low-Level Laser Therapy on the Viability and Secretory Activity of Resting Macrophages - Mdpi.com
Article by Aleksandra Matuła, Amelia Lizak, Ewa Stodolak-Zych, Aneta Bac et al. (Poland - Biomedicines). The research results indicate that the effect of LLLT on resting macrophages modulates their biological activity, and the intensity of photobiostimulation depends on the irradiation parameters, including wavelength, power, dose and method of laser beam application.

Recent Trends in the Application of Cellulose-Based Hemostatic and Wound Healing Dressings - Mdpi.com
Article by Clemence Futila Bukatuka, Bricard Mbituyimana, Lin Xiao, Abeer Ahmed Qaed Ahmed et al. (China, Italy - JFB). This review also covers challenges and future trends, emphasizing the need to enhance mechanical properties and biodegradability. Further, new technologies offer potential improvements to the nanocomposites.

Efficacy and safety of negative pressure wound therapy in the treatment of patients with cardiovascular implantable electronic devices pocket infection - Biomedcentral.com
Article by Genmiao Yu, Xiongmei Huang, Rongjia Lin and Shengwu Zheng (Fuzhou, China - BMC Cardiovascular Disorders). NPWT is an effective alternative for patients with cardiac implantable electronic device (CIED) pocket infections who are unsuitable or unwilling to undergo CIED and leads extraction.

Sociodemographic predictive factors of increased hospital stay and cost among hospitalised patients with pressure injuries - National Inpatient Sample 2009–2019 (pooled sample) - Wiley.com
Article by Siri Choragudi and Robert S. Kirsner (USA - Wound Repair and Regeneration). Significant disparities exist in hospital outcomes for patients with pressure injuries. Targeted interventions are needed to address these inequalities and improve patient care.

The Role of Lactic Acid in Episiotomy Wound Healing: A Systematic Review - Mdpi.com
Article by Dragos Brezeanu, Ana-Maria Brezeanu, Sergiu Chirilă and Vlad Tica (Romania - Healthcare). Lactic acid shows promise in episiotomy wound care by improving healing outcomes and reducing infection and discomfort.

Advancing in vitro cell migration studies: a review of open-source analytical platforms for cancer and wound healing research - Tandfonline.com
Article by Abhayraj S. Joshi (Manipal, India - Cell Adhesion & Migration). This review aims to provide insights into these open-source tools and serves as a practical guide to both biologists and computational researchers for their specific analytical needs.

A murine pressure ulcer model for evaluating persistence and treatment of Staphylococcus aureus infection - PubMed
Abstract by Michele Tavecchio, Silvia Fanni, Xuemin Wu, Ganna Petruk et al. (Lund, Sweden - Front Med (Lausanne))

Artificial Intelligence Versus Human Systematic Literature Review Into Negative-pressure Wound Therapy in Plastic Surgery - Nih.gov
Article by Augustine J Deering III, Payden A Harrah, Melinda Lue, Daanish Sheikh, C Anton Fries (USA - Plast Reconstr Surg Glob Open). AI is a promising tool but remains limited in accurately determining evidence quality. AI’s lower scores may reflect reduced bias. Multiple confounders and the diversity of its application lead to a lack of high-level evidence of NPWT’s efficacy.

Natural Products from the Mediterranean Area as Wound Healing Agents - In Vitro Studies: A Systematic Review - Mdpi.com
Article by Eleftheria Chorti-Tripsa, Vasilis-Zois Galanis, Theodoros C. Constantinides and Christos Kontogiorgis (Alexandroupolis, Greece - Antioxidants). The studies showed that many natural products found in the Mediterranean have been studied for the treatment of wounds. The wound healing effect seems to be related to dose, type of wounded tissue, and application time.

Transforming wound care: Enzymatic debridement and the future of healing - Hospitalnews.com
Article by Robert Snyder. The wound care industry is evolving, and enzymatic debridement is at the forefront of this revolution. Bromelain-based solutions offer the treatment that practitioners need, delivering faster healing times, reduced biofilm, supporting robust granulation tissue, and transitioning towards home-based care. As we step into this new era of wound care, the combination of enzymatic therapies and technological advances hold the key to unlocking unprecedented possibilities for patients and healthcare professionals alike.

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial - Thelancet.com
Article by Catherine Arundel, Laura Mandefield, Caroline Fairhurst, Kalpita Baird et al. (York, UK - The Lancet). In patients with a lower limb SWHSI, including those with complications of diabetes, there is no clear evidence that NPWT reduced the time to wound healing compared with standard dressings. These findings do not support the use of NPWT to augment SWHSI healing.

Empa scientists create innovative hydrogel for simulating the human skin - News-medical.net
Growing cells in the laboratory is an art that humans have mastered decades ago. Recreating entire three-dimensional tissues is much more challenging. Empa researchers are developing a new hydrogel-based material that makes it possible to engineer artificial skin tissues, which can serve as living three-dimensional models of human skin for better understanding and treating skin diseases.

Clinical Effects of Weekly and Biweekly Low-Frequency Ultrasound Debridement Versus Standard of Wound Care in Patients with Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial - PubMed
Abstract by Sebastián Flores-Escobar, Yolanda García-Álvarez, Francisco Javier Álvaro-Afonso, Mateo López-Moral et al. (Madrid, Spain - Int J Low Extrem Wounds).

Analysis of the distribution characteristics of infecting microorganisms in the wound tissue of patients with perianal abscess combined with infection and the influencing factors of wound healing - Biomedcentral.com
Article by Luji Qiao, Hongjian Gao, Yi You and Jinliang Zhu (Shenyang, China - BMC Gastroenterology). This study suggests that BMI, diabetes, concurrent infection and stool characteristics are independent risk factors for poor wound healing in patients with perianal abscess and infection.

Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine - Biomedcentral.com
Article by Ke Gao and Ke Xu (Hangzhou, China - Gels). This review systematically elaborates on the current research progress and future challenges regarding pH-responsive hydrogels in biomedical applications, with particular emphasis on their stimulus–response mechanisms, fabrication methodologies, multifunctional integration strategies, and application scenarios.

Comparative Study between Platelet-rich Plasma, Platelet-derived Growth Factor Gel, and Normal Saline Dressing in Chronic Ulcer Healing - Lww.com
Article by M. V. Devesvar, Sunil Kumar Shetty and Kawari Sowbhagyalaxmi Ramesh (Karnataka, India - Annals of African Medicine). This study concludes that PRP is a highly effective treatment for chronic ulcers, offering faster wound healing and greater wound size reduction compared to PDGF gel and normal saline dressing. PDGF gel also presents a viable alternative with good efficacy. Normal saline, while less effective, remains a baseline treatment option.

Healing with Love: Oxytocin Accelerates Oral Ulcer Recovery by Reducing Inflammation - Mdpi.com
Article by Mert Zeytinoğlu, Osman Sezer Çınaroğlu, Ejder Saylav Bora and Oytun Erbaş (Turkey - JCM). Oxytocin accelerates oral ulcer healing by modulating inflammation, oxidative stress, and ECM remodeling via the MMP-2/TIMP-2 pathway.

The Psychological Impact of Wounds: How Faster Healing Improves Patient Wellbeing - Axiobio.com
Chronic wounds impact both physical and mental health, causing stress, pain, and emotional distress. Faster healing with innovative wound care dressings helps restore independence, confidence, and quality of life. By utilizing chitosan wound dressing technology, gelling fiber dressings, antimicrobial dressings, and hydrobalancing dressings, healthcare providers can ensure superior wound management.

Negative Pressure Wound Therapy in the Prevention of Surgical Site Infections Following Abdominal Surgery: A Systematic Review - Cureus.com
Article by Karim A. Bastawisy, Baran Dilshad Hassan, Muhammad Muaz Loon, Sergio Rodrigo Oliveira Souza Lima and Muhammad Ali (UK, Iraq, Brazil, Pakistan). The authors' results support the targeted use of NPWT in high-risk abdominal surgeries, though further large-scale, multicenter trials are needed to refine patient selection criteria and optimize clinical application.

Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review - Biomedcentral.com
Article by Sona Zare, Alireza Jafarzadeh, Solmaz Zare and Amir Shamloo (Tehran, Iran - Stem Cell Res Ther.). This review underscores the potential of MSC-derived conditioned media in dermatology. Several studies also highlighted its enhanced therapeutic effects when combined with adjunctive treatments, such as laser therapy and microneedling, showcasing improved outcomes in dermatological care.

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate - Acs.org
Abstract by Ismaeel Muhamed, Erin P. Sproul, Frances S. Ligler and Ashley C. Brown (Raleigh, USA - ACS Applied Materials & Interfaces).

Construction of a Nutrition Management Guidance Flowchart for Patients With Chronic Wounds Based on Best Evidence - Nih.gov
Article by Huan Liu, Chunxiao Liu, Donghua Ma, Xuefen Shen et al. (Hangzhou, China - Int Wound J.). The best evidence of nutrition management in patients with chronic wounds was summarised, and a nutrition management guidance flowchart based on this was constructed, which can provide references for medical staff to guide nutrition management for patients with chronic wounds.

Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in type 2 diabetic Goto-Kakizaki (GK) rats - Frontiersin.org
Article by Sineenart Sanpinit, Acharaporn Issuriya, Oraphan Sakulkeo, Palika Wetchakul et al. (Thailand, China - Front. Pharmacol.). This discovery reveals, for the first time, the underlying mechanisms of action of this traditional formulation, highlighting its potential as a cost-effective alternative for managing chronic wounds in resource-limited settings.

Safety and Effectiveness of a Fixed-Dose Combination of Trypsin, Bromelain, and Rutoside in Wound Management: A Randomized Clinical Trial - Cureus.com
Article by Bhupesh Dewan, Siddheshwar Shinde and Nisha Motwani (Mumbai, India). The authors' suggest that Tibrolin® administration favors wound healing and improves wound symptoms, such as edema, inflammation, and pain in the management of elective clean, uncontaminated surgical wounds.

Risk Factors of Pressure Sores Development Among Patients in Adult Intensive Care Unit: Exploring from E-Medical Record - PubMed
Abstract by Warantorn Potarin, Santisith Khiewkhern, Thidarat Somdee, Kemika Sombatyotha et al. (Thailand - Stud Health Technol Inform.).

Enzymatic Debridement Is More Effective than Autolytic for Severe Wounds - Dermatologytimes.com
Podcast by Marie Bosslett. The choice of debridement technique significantly influences the rate of wound healing, patient comfort, and overall clinical outcomes.

Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation - Plos.org
Article by Archana Prabahar, Connie S. Chamberlain, Ray Vanderby, William L. Murphy et al. (USA - Computational Biology). The transcription factors, known for their roles in bone regeneration, skeletal patterning, osteoblast activity, fracture healing, angiogenesis, and key signaling pathways, may act as master regulators of the regenerative gene signatures.

Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes - Mdpi.com
Article by Natalia Chylińska and Mateusz Maciejczyk (Bialystok, Poland - Gels). This review summarizes the current background knowledge about the role of HA in skin aging and wound healing.

Interpretable deep learning method to predict wound healing progress based on collagen fibers in wound tissue - Sciencedirect.com
Abstract by Juan He, Xiaoyan Wang, Zhengshan Wang, Ruitao Xie et al. (Macau, China - Computers in Biology and Medicine).

Antibiotic Action, Drug Delivery, Biodegradability, and Wound Regeneration Characteristics of Surgical Sutures and Cutting-Edge Surgical Suture Manufacturing Technologies - Mdpi.com
Article by Hye-Ree Han (Republic of Korea - JFB). The results of this study can contribute to the development of multifunctional surgical sutures that promote wound regeneration through antibacterial properties, drug elution, and biodegradability.

Why Hyaluronic Acid is an Ideal Material for Wound Healing - Stanfordchem.com
Normal wound healing involves stages such as hemostasis, inflammation, proliferation, and remodeling. Throughout these stages, hyaluronic acid plays an active role, hence it qualifies as an ideal material for wound healing.

Effectiveness of quality and quantity mononuclear cells for enhancing wound healing in diabetic ischemic limb animal model - Wiley.com
Article by Pongpol Sriphan, Nuttapol Chruewkamlow, Chutipon Sathan-ard, Phakawan Phutthakunphithak et al. (Bangkok, Thailand - International Wound Journal). The findings of this study highlight the effectiveness of Quality and Quantity mononuclear cells for promoting wound healing and limb salvage in diabetic ischemic animal model; however, clinical trials are needed to further assess their efficacy in this clinical context.

Evaluation of a Virtual Human in Delivering Relaxation Exercises for Wound Healing and Stress Reduction: A Randomised Controlled Trial - Mdpi.com
Article by Isabella Pickering, Mikaela Law, Kate Loveys, Mark Sagar et al. (New Zealand, Austria - MTI). Relaxation instructions delivered by a virtual human increased participants’ relaxation levels with similar effects to traditional audiotapes. Furthermore, it reduced physiological stress indices.

Digital wound monitoring with artificial intelligence to prioritise surgical wounds in cardiac surgery patients for priority or standard review: protocol for a randomised feasibility trial (WISDOM) - Bmj.com
Article by Judith Tanner, Melissa Rochon, Roy Harris, Jacqueline Beckhelling et al. (UK - BMJ Open). This is a feasibility study for a new artificial intelligence module with 120 cardiac surgery patients at two centres serving a range of patient ethnicities and urban, rural and coastal locations. Each patient will be randomly allocated using a 1:1 ratio with mixed block sizes to receive the platform with the new detection and prioritising module (for up to 30 days after surgery) plus standard postoperative wound care or standard postoperative wound care only.

From Traditional to Single Use: The Evolution of Negative Pressure Wound Therapy as a Mechanism for Optimal Wound Management - Hmpgloballearningnetwork.com
The utilization of tNPWT is ideally positioned for large, deep, highly exuding wounds. However, by assessing a wound’s dimensions and exudate volume and type, a more appropriate NPWT device selection can be made; thus, ensuring the delivery of therapy with the most suitable device modality appropriate for the wound and patient while also maximizing resources.

Development of a Decellularized Extracellular Matrix-Derived Wet Adhesive for Sustained Drug Delivery and Enhanced Wound Healing - Sciencedirect.com
Article by Xinming Wang, Haonan Zhang, Weichang Xie, Bei Qian et al. (Shanghai, China - Materials Today Bio). Extracellular matrix (ECM)-dopamine loaded with insulin-like growth factor-1 promotes skeletal muscle regeneration in a mouse volumetric muscle loss model, likely through the modulation of M2-like macrophage polarization. The dual functionality of ECM-dopamine as both a wet adhesive and a drug delivery platform offers significant potential for regenerative medicine applications.

Healing Rate and Time to Closure of Venous Leg Ulcers: A Real-World Service Evaluation of Neuromuscular Electrostimulation as an Adjunct to Compression Therapy - PubMed
Abstract by Holly Murray, Rochelle Duong and Duncan Shirreffs Bain (Canada, UK - Adv Skin Wound Care).

Optimizing Chart Review Efficiency in Pressure Injury Evaluation Using ChatGPT - Lww.com
Abstract by Rebecca Friedman, Rebecca Lisk, Katherine Cordero-Bermudez, Soniya Singh et al. (USA - Ann Plast Surg.).

A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects - Nature.com
Article by Eiichi Sawaragi, Michiharu Sakamoto, Yasuhiro Katayama, Shingo Kawabata et al. (Japan - Scientific Reports). This study concluded that silk elastin sponges may be an effective new option for wounds that are unresponsive to existing treatments.

Povidone Iodine Induced Apoptosis and Its Effect on Wound Healing in Human Dermal Fibroblasts - Oup.com
Abstract by Sam Jacob, Amina El Ayadi and Joseph Wenke (USA - Journal of Burn Care & Research).

Investigating the Protective Effects of Frankincense Oil on Wound Healing with GC–MS - Chromatographyonline.com
Article by John Chasse. The research determined that frankincense essential oil demonstrates significant potential in the promotion of wound healing through the effective regulation of significant cellular and molecular mechanisms.

A Review of Wearable Electroceutical Devices for Chronic Wound Healing - Mdpi.com
Article by Ali Abba Mutah, Joseph Amitrano, Mark A. Seeley and Dhruv Seshadri (USA - Electronics). The authors identified direct, pulsed, and alternating electric currents as the primary modalities by electroceutical devices to deliver electrical stimulation in chronic wounds. Typical chronic wounds identified include diabetic foot ulcers, pressure ulcers, and diabetic venous ulcers.

In vitro evaluation of the capability of a silicone superabsorbent polymer (SAP) dressing to modulate pro-inflammatory cytokines - Woundsinternational.com
Article by Christopher Ball, Colby Taylor, Breno Salgado, Erzsébet Szabóné Révész and Clemens Heller (UK, Hungary, Germany - Wounds International). The self-adhesive silicone superabsorbent polymer dressing tested in this study demonstrated greater protein modulation when compared to a panel of currently available alternate dressing types.

Carbon dot based dressing for therapy of chemically-induced cutaneous burns - Nature.com
Article by Halyna Kuznietsova, Arsen Ishchuk, Iryna Byelinska, Tetiana Lysenko et al. (Ukraine - Scientific Reports). Carbon dots accelerated healing, particularly in alkali burns, and had a systemic effect on immune and inflammatory responses.

Recent Research Progress of Wound Healing Biomaterials Containing Platelet-Rich Plasma - Dovepress.com
Article by Sha Huang, Qing Li, Xiangyu Li, Hailing Ye et al. (Zhejiang, China - International Journal of Nanomedicine). This article reviews the latest research progress of biomaterials combined with PRP in the treatment of wounds, aiming to provide references for PRP wound treatment, as well as to provide ideas for the development of subsequent medical materials.