Elucidation and valorization of the potent activity of Commiphora myrrha gum resin extract: antimicrobial and fibroblast wound healing activities - Mdpi.com
Article by Rowena Mohamed Khalil, Nevine B. Ghanem and Heba Khairy (Alexandria, Egypt - Scientific Reports).
This is the first study to comprehensively link the ethyl acetate fraction of C. myrrha to both antimicrobial and wound-healing activity, supporting its development as a multifunctional therapeutic agent. The results validate its traditional use and highlight its potential in modern pharmaceutical and nutraceutical applications.
Unraveling the Mechanisms of Madecassoside Derivatives in Wound Healing: Network Pharmacology and Experimental Validation - Mdpi.com
Article by Jing Liu,Yuanyuan Li, Cheng Yang and Bingtian Zhao (Wuxi, China - Pharmaceuticals).
This paper represents the first report directly comparing the biological activities of the parent compound (madecassoside) and its metabolites while simultaneously proposing a novel therapeutic strategy for wound healing.
Platelet-Rich Plasma for Wound Healing in Diabetic Patients - Mdpi.com
Article by Elean Zanzov, Vanya Anastasova, Karina Ivanova and Petar Kiskinov (Plovdiv, Bulgaria - Medicina).
While PRP therapy demonstrates significant potential in the management of diabetic foot ulcers, further randomized controlled trials with standardized methodologies are essential to establish optimal treatment protocols and confirm long-term benefits. PRP offers a minimally invasive, autologous, and biologically active treatment modality that may serve as a vital component in the multidisciplinary approach to DFU management.
Use of a Novel Zipper Device for Wound Closure of Cutaneous Abscesses in Pediatric Outpatients: A Case Series - Hmpgloballearningnetwork.com
Article by Wei Bingting, Yang Chen, Ma Wei, Xie Mingjing et al. (China).
This case series identifies the fifth day post-incision and drainage as a potential threshold, and suggests that the optimal period of zipper device use is 3 days to 5 days following I&D of skin abscess to enhance early wound healing, beyond which extended intervention intervals prolong wound healing time.
Stem Cells in Regenerative Medicine: A Journey from Adult Stem Cells to Induced Pluripotent Cells - Mdpi.com
Article by Ylenia Della Rocca, Antonella Mazzone, Guya Diletta Marconi, Oriana Trubiani et al. (Italy - IJMS).
The stem cells involved in the identification of new regenerative therapeutic approaches are analyzed here through a classification based on the tissues’ embryonic derivation: stem cells from ectodermal derivation tissues, stem cells from mesodermal derivation tissues, stem cells from endodermal derivation tissues, and induced pluripotent stem cells.
Biological Skin Substitutes in Pressure Ulcers: High-Purity Type I Collagen-Based Versus Amnion/Chorion Membrane - Cureus.com
Article by Naveen Narayan, Yashas H. Ramegowda, Divakara S. Raghupathi, Shivannaiah Chethan and Suhas Gowda (India).
Helicoll® (high‐purity type I collagen) showed numerically superior healing rates, improved tissue regeneration parameters, required fewer reapplications with better structural stability of the healed wound, improved patient satisfaction outcomes compared to dHACM, suggesting potential clinical and economic advantages.
Effects of motivational and early warning nursing on wound healing and socio-psychological adaptability in hepatobiliary surgical patients - Wjgnet.com
Article by Ya-Juan Shan, Ding-Feng Yu, Wei-Ying Xu, Su-Qin Tu and Yue-Ping Ge (China - World Journal of Gastrointestinal Surgery).
Motivational and early warning nursing interventions are beneficial for promoting wound healing in patients undergoing hepatobiliary surgery, reducing the incidence of complications and improving socio-psychological adaptability and postoperative quality of life. These interventions should be promoted in clinical nursing practice.
Conditioned plasma promotes full-thickness skin defect healing in a rat model - Sciencedirect.com
Article by Majid Zamani, Saeid Kaviani, Mehdi Yousefi, Saeid Abroun et al. (Iran - Regenerative Therapy).
CP promotes wound healing by increasing epithelialization, fibroblast proliferation, collagen synthesis and deposition, and reducing inflammatory cells infiltration.
Social isolation in wound healing requires a tapestry of care - Lww.com
Abstract by Alisha Oropallo (USA - Nursing).
Advanced nanofiber therapy: multifunctional silver-nanoparticles@polyacrylonitrile incorporating Syzygium guineense extracts for enhanced in vivo diabetic wound-healing and robust antimicrobial defense - Rsc.org
Article by Teshale Ayano Begeno, Yaqi Zhang, Abdurohman Mengesha Yessuf, Tibebu Shiferaw Kassa et al. (Beijing, China - Nanoscale Advances).
The authors' findings underscore the potent antioxidant and antibacterial properties of Bio-Ag NPs, emphasizing their potential for diverse biomedical applications.
Comparative Study of Wound Healing in Cellulitis Patients With and
without Diabetes in a Tertiary Care Hospital - Ijrpr.com
Article by Junior Sunderesh, Anto Joel Roy and Aarthy. P. (Annamalainagar, India - International Journal of Research Publication and Review).
Diabetic cellulitis patients experience delayed wound healing and higher complication rates compared to non-diabetic counterparts. Strict glycaemic control and early intervention are essential for improving outcomes.
Integrating Regenerative Medicine in Chronic Wound Management: A Single-Center Experience - Mdpi.com
Article by Stefania-Mihaela Riza, Andrei-Ludovic Porosnicu, Patricia-Alina Cepi, Sorin Viorel Parasca and Ruxandra-Diana Sinescu (Bucharest, Romania - Biomedicines).
Platelet-rich plasma (PRP) therapy proved to be a safe, effective, and adaptable treatment, promoting substantial healing in chronic wounds. Autologous adipose tissue transfer did not confer additional benefit. PRP may warrant inclusion in national treatment protocols.
Molecular Insights into the Interaction of Cathepsin D and Iron in Chronic Wound Healing: Exploring Therapeutic Potential and Mechanisms - Mdpi.com
Article by María Rodríguez-Moreno and Isabel Legaz (Murcia, Spain - Biomedicines).
Cathepsin D, an aspartate protease active in acidic environments, plays a pivotal role in wound healing by mediating inflammatory responses, ECM remodeling, and macrophage phenotype transitions.
Plant Extracts as Modulators of the Wound Healing Process—Preliminary Study - Nih.gov
Article by Anna Herman, Aleksandra Leska, Patrycja Wińska and Andrzej Przemysław Herman (Poland - Int J Mol Sci.).
The authors' study showed that some plant extracts may be promising modulators of the wound healing process, although further in-depth studies are necessary to determine their effectiveness in the in vivo model.
Research Hotspots in Natural Products for Wound Healing: A Bibliometric Analysis and Literature Review - Dovepress.com
Article by Fan Yang, Zhengyi Fang, Mengfan Yang, Zilin Cheng et al. (Chengdu, China - Clinical, Cosmetic and Investigational Dermatology).
The study of the relationship between natural products and wound healing has a promising future, and translational research targeting natural products will be the focus of future chronic wound therapy research.
Pioneering 3D and 4D Bioprinting Strategies for Advanced Wound Management: From Design to Healing - PubMed
Abstract by Amit K Yadav, Damini Verma, Shreya Thakkar, Yukta Rana et al. (India - Small.).
Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring - Mdpi.com
Article by Xinghan He,Yongyi Wei and Ke Xu (Hangzhou, China - Gels).
Critical challenges in material development and scalable manufacturing of multifunctional hydrogel components are discussed, alongside prospects for precision diagnostics and therapeutics in diabetic wound care.
A Comprehensive Scoping Review on the Use of Point-Of-Care Infrared Thermography Devices for Assessing Various Wound Types - Wiley.com
Article by Samia Rahman, Tessa Ogilvie, Daria Okonski, Kaitlyn Ramsay et al. (Canada - International Wound Journal).
Point-of-care thermography demonstrates significant potential to enhance wound assessment and monitoring, thereby elevating care quality and patient outcomes.
A Review of Chronic Wounds and Their Impact on Negative Affect, Cognition, and Quality of Life - Wiley.com
Article by Maria C. Redmond, Georgina Gethin and David P. Finn (Galway, Ireland - International Wound Journal).
Research suggests that there are deficiencies in the management of anxiety, depression, and cognitive impairment in people with chronic wounds, but developing and administering therapies that target these comorbidities may have a positive impact on quality of life and wound healing. Integration of mental health and cognition screening into wound care protocols would provide substantial benefits both socioeconomically and to individuals with chronic wounds.
Does Nurses' Fatigue Level Affect Their Self-Efficacy in Pressure Injury Management? A Multi-Center Cross-Sectional Study - Wiley.com
Article by Elif Acar and Tuba Sengul (Istanbul, Turkey - International Wound Journal).
Although no significant relationship was found between fatigue and self-efficacy, occupational factors such as poor sleep quality, long working hours and irregular shift patterns were associated with increased fatigue. In contrast, higher educational attainment, greater knowledge about pressure injury and participation in professional training significantly enhanced nurses' self-efficacy in PI management. This study offers some early data on the possible role of occupational fatigue and PI preventive practices.
Optimizing Nutrition Interventions for Effective Prevention and Treatment of Pressure Injuries: Fostering a Collaborative Health Care Team Approach - Woundsource.com
Article by Brian McCurdy.
At a recent WoundCon Summer session, panelists defined pressure injuries and their stages and discussed how nutritional intervention, including multidisciplinary collaboration, can prevent these injuries.
Hospital-Acquired Pressure Injuries: Application of Preventive and Reactive Measures in Real Practice - PubMed
Abstract by Gloria Lorente-Granados, Ángel Arias-Arias, Sonia Villajos-García, Gema Gallego-Doncel et al. (Spain - J Adv Nurs.).
Wound Healing in Diabetic Patients Undergoing Abdominal Surgery: A Retrospective Study - Cureus.com
Article by Tiba Fadhil, Amna Batool, Hussain Khan and Muhammad Shahid Farooq (Lahore, Pakistan).
Diabetic people had worse postoperative wound healing after abdominal surgery. Glycemic control and perioperative strategies may help improve surgical outcomes.
Reconstruction of Electrical Burn Wounds Using Acellular Dermal Matrix: A Case Report and Literature Review - Cureus.com
Article by Rodrigo Davila-diaz, Edwing Michel Jaimes-Duran, Mauricio Gutierrez-Alvarez, Carlos Cortes-Aguilar et al. (Mexico City, Mexico).
Acellular dermal matrix is a viable option for the management and coverage of electrical burn injuries, promoting wound healing and reducing complications.
An Effective Solution to Accelerate the Healing of Complex Ulcers Using Recombinant Human Epidermal Growth Factor (Intralesional Application): A Review - Tandfonline.com
Article by Maria Teresa Cacua Sánchez and Carlos Alberto Carillo Bravo (Bogotá, Colombia - Drug Design, Development and Therapy).
RrhEGF has been established as a safe and effective therapeutic tool with the potential to transform the conventional management of chronic and complex ulcers, improving clinical outcomes and enhancing patients’ quality of life.
Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing - Nature.com
Article by Ayman Mohammed El Makakey, Mohammed H. Hassan, Nehad A. Abo-zaid, Bakheet E. M. Elsadek et al. (Egypt - Scientific Reports).
Microcurrent therapy and low-level laser therapy have a notable impact in improving wound healing process as they can significantly affect the expression levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases towards good prognosis of healing process and decreasing possible wound healing complication, with superior effect of low-level laser therapy.
Syringin (Sinapyl Alcohol 4-O-Glucoside) Improves the Wound Healing Capacity of Fibroblasts and Keratinocytes In Vitro - Mdpi.com
Article by Andrzej Parzonko, Agnieszka Filipek, Marcin Równicki and Anna K. Kiss (Warsaw, Poland - IJMS).
The present study demonstrated that syringin present in S. vulgaris stem bark increased dermal fibroblasts and keratinocytes’ wound healing function through activation of cell migration.
Ayurvedic and Modern Surgical Approaches to Non-Healing Wounds: A Comprehensive Review - Jaims.in
Article by Rai and Suman (India - JAIMS).
This review explores the principles and practices of wound management in Ayurveda, focusing on Vrana Ropana (wound healing) and modern surgical techniques. The article aims to highlight integrative approaches that can optimize patient outcomes through a deeper understanding of both traditional and contemporary methodologies.
Mechanistic Perspectives on Radiation-Induced Skin Injury and the Protective Effects of Berberine - Dovepress.com
Article by Biao Huang, Gong Chen, Tao Yan, Xiaolan Ou et al. (China - Journal of Inflammation Research).
Radiation injury leads to persistent senescence, inflammation, and impaired wound healing in skin tissues. CDKN1A, IGFBP7, and CTSL are core senescence markers in RISI.
The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review - Nih.gov
Article by Sadie Badrie, Zena Moore, Declan Patton, Tom O'Connor and Rosemarie Derwin (Ireland, UK - Int Wound J).
Autofluorescence imaging enhances wound assessment by improving bacterial detection and may support more targeted clinical interventions.
Gold Nanoparticles for Wound Healing in Animal Models - Mdpi.com
Article by Stephen Klavsen and Sten Rasmussen (Aalborg, Denmark - Nanomaterials).
Gold nanoparticles significantly accelerate wound healing in animal models, supporting their potential as therapeutic agents.
Curcumin-Loaded Drug Delivery Systems for Acute and Chronic Wound Management: A Review - Mdpi.com
Article by Xiaoxuan Deng, Jithendra Ratnayake and Azam Ali (Dunedin, New Zealand - Bioengineering).
This review explores curcumin-loaded dressings, such as hydrogels, nanofibrous membranes, polymeric micelles, and films, offering controlled drug release and targeted curcumin delivery to enhance wound healing.
Why Some Wounds Don’t Leave Scars - The-scientist.com
Article by Sahana Sitaraman.
Oral wounds heal without a trace, but skin scrapes don’t. Scientists decoded molecular players that drive scarless healing, paving the way for better skin repair therapies.
Nanofibrous Dressings Modified with Antibacterial Polylysine and Anti-inflammatory Tannic Acid for Infected Wound Healing - Sciencedirect.com
Article by Wei Xu, Tingting Xu, Lei Yu, Xuchao Ning et al. (China - Materials Today Bio).
The authors' findings highlight the therapeutic potential of PLys@TA-modified nanofibrous dressings for managing chronic, full-thickness wounds.
Evaluation of risk factors for poor wound healing after cesarean delivery in patients with gestational diabetes mellitus: a retrospective study - Biomedcentral.com
Article by Yan Liu, Ye Wang, Shao-Hua Gao, Hui Wu et al. (China - BMC Surgery).
Prolonged operative time, premature rupture of membranes, emergency cesarean delivery, and uterine scarring were identified as independent risk factors for poor wound healing in gestational diabetes mellitus patients. Candida infection also showed a statistical association but was based on limited case numbers and should be interpreted cautiously.
Plant Extracts as Modulators of the Wound Healing Process - Preliminary Study - Mdpi.com
Article by Anna Herman, Aleksandra Leska, Patrycja Wińska and Andrzej Przemysław Herman (Poland, IJMS).
The authors' preliminary study showed that some plant extracts may be promising modulators of the wound healing process, although further in-depth studies are necessary to determine their effectiveness in the in vivo model.
Casein-Based Biomaterials: Fabrication and Wound Healing Applications - Mdpi.com
Article by Nikolay Estiven Gomez Mesa, Krasimir Vasilev and Youhong Tang (Adelaide, Australia - Molecules).
The gathered evidence highlights casein’s versatile bioactivity and dynamic molecular properties, positioning it as a promising platform to address advanced wound dressing challenges.
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