Advancing chronic and acute wound healing with cold atmospheric plasma: cellular and molecular mechanisms, benefits, risks, and future directions - Frontiersin.org
Article by Nastaran Raissi-Dehkordi, Negar Raissi-Dehkordi, Hamed Ebrahimibagha, Tahereh Tayebi et al. (Tehran, Iran - Front. Med.).
Despite promising results, translating cold atmospheric plasma into routine clinical practice requires addressing challenges such as standardizing treatment protocols, assessing long-term safety, and developing portable devices.
Functional Properties of Gelatin–Alginate Hydrogels for Use in Chronic Wound Healing Applications - Mdpi
Article by Olha Maikovych, Pamela Pasetto, Nataliia Nosova, Olena Kudina et al. (Ukraine, France, Ireland - Gels).
It was demonstrated that the antiseptic (chlorhexidine) contained in the structured gelatin–alginate hydrogels can be released into an infected substrate, resulting in a significant inhibition of pathogenic microorganisms (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Aspergillus niger).
Development and Characterization of Biocompatible Chitosan-Aloe Vera Films Functionalized with Gluconolactone and Sorbitol for Advanced Wound Healing Applications - Acs.org
Article by Beata Kaczmarek-Szczepańska, Patrycja Glajc. Dorota Chmielniak. Klaudia Gwizdalska et al. (Torun, Poland - ACS Applied Materials & Interfaces).
The authors' research underscores the potential of combining CS with A, GL, and S to engineer multifunctional biomaterials tailored for effectively tackling different phases of the wound healing process, offering a sustainable and biocompatible alternative for clinical applications.
Multifaceted Pathophysiology and Secondary Complications of Chronic Spinal Cord Injury: Focus on Pressure Injury - Mdpi.com
Article by Mario Martínez-Torija, Pedro F. Esteban, Angela Santos-de-la-Mata, Matilde Castillo-Hermoso et al. (Toledo, Spain - JCM).
Chronic SCI induces a cascade of physiological changes that predispose patients to the development of PIs and complicate their recovery. The intricate interplay of vascular, metabolic, and inflammatory responses creates a hostile environment for wound healing. A deeper understanding of these systemic effects is essential not only for developing targeted therapeutic strategies to improve chronic wound healing but also for refining preventive approaches that minimize their occurrence.
Development and Characterization of Biocompatible Chitosan-Aloe Vera Films Functionalized with Gluconolactone and Sorbitol for Advanced Wound Healing Applications - Acs.org
Article by Beata Kaczmarek-Szczepańska, Patrycja Glajc. Dorota Chmielniak. Klaudia Gwizdalska et al. (Torun, Poland - ACS Applied Materials & Interfaces).
The authors' research underscores the potential of combining CS with A, GL, and S to engineer multifunctional biomaterials tailored for effectively tackling different phases of the wound healing process, offering a sustainable and biocompatible alternative for clinical applications.
Green Tea Polyphenols in Wound Healing: Therapeutic Mechanisms, Potential Applications and Challenges in Commercial Use for Diabetic Wound Healing - Mdpi.com
Article by Syeda Attiqa Tajammal, Austin Coffey and Shiau Pin Tan (Ireland - Processes).
By consolidating current knowledge and identifying gaps, this review aims to inspire future research and innovations in using green tea for effective wound management and potential use in diabetic patients and DFUs, if the positive results from animal in vivo studies are equally effective in human clinical studies.
What to Eat for Wound Healing - Healthxchange.sg
It is crucial to have enough calories from your meals in the form of carbohydrates, protein and fat. Without sufficient calories, our bodies will then tap on our energy stores and protein from our muscles to produce energy to meet our needs. This in turn leads to muscle wasting, which further impairs the wound healing process.
Negative pressure wound therapy promotes wound healing by down-regulating miR-155 expression in granulation tissue of diabetic foot ulcers - Nature.com
Article by Yixuan Huang, Zhenyi Yu, Murong Xu, Xiaotong Zhao et al. (Anhui, China - Scientific Reports).
The authors concluded that NPWT promotes DFU healing by reducing the expression of miR-155 in granulation tissue and the efficacy of NPWT correlated with altered miR-155 expression in wound tissue.
The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice - Mdpi.com
Article by Gadi Borkow and Eyal Melamed (Israel - Biomedicines).
Copper is essential for wound healing, and copper-impregnated dressings provide a promising solution for chronic wound management. By enhancing angiogenesis and tissue regeneration, these dressings go beyond antimicrobial action, offering a cost-effective and innovative alternative to conventional therapies. Copper dressings represent a transformative advancement in addressing the challenges of chronic wound care.
Benefits of Combined Therapies in Burn Lesions: Enzymatic Debridement and Other Modern Approaches—Our Clinical Experience - Mdpi.com
Article by Angela Tecuceanu, Camelia Tamaş, Anca Sava, Ruxandra Vatavu et al. (Romania - Life).
Nexobrid® in combination with NWPT is a promising alternative to surgical treatment, improving healing, reducing the need for skin grafts, and alleviating pain associated with dressing changes. It may be particularly useful in extensive burns, where epithelial reserves are limited.
Advances in Wearable Biosensors for Wound Healing and Infection Monitoring - Mdpi.com
Article by Dang-Khoa Vo and Kieu The Loan Trinh (Rep. of Korea - Biosensors).
The goal of this review is to synthesize current trends, challenges, and future directions in wound healing and infection monitoring, with emphasis on the potential for wearable biosensors to improve patient outcomes and reduce healthcare burdens. These innovations are leading the way toward next-generation wound care by bridging advanced materials science, biotechnology, and digital health.
Is Negative Pressure Wound Therapy Better for Sternal Wound Healing? - Thieme-connect.com
Abstract by Z. T. Taghiyev, J. F. Sandoval Valderrama, B. Nieman, P. Roth et al. (Giessen, Germany).
Utility of Excision and Direct Closure in Burns: A Case Report and Review of the Literature - Cureus.com
Article by Nhan S. Trieu, Jonathan Butts, Peter Vonu, Shawn Larson and Kalyan Dadireddy (Gainesville, USA).
While having similar rates of postoperative complications to traditional burn treatment, excision and direct closure offer several advantages. However, primary closure may not be suitable for patients with an extensive burn surface area without an adequate tissue reservoir. Therefore, this technique should be further investigated as the treatment option for a selective burn population.
The application of traditional Chinese medicine polysaccharides in wound healing: A review - Sciencedirect.com
Abstract by Minrui Ji and Zaixin Yuan (Nantong, China - International Journal of Biological Macromolecules).
Harnessing Manuka Honey: A Natural Remedy for Accelerated Burn Wound Healing in a Porcine Model - Mdpi.com
Article by Boris Privrodski, Mladen Jovanović, Nikola Delić, Radomir Ratajac et al. (Novi Sad, Serbia - Pharmaceuticals).
The authors' findings support the potential of Manuka honey as a beneficial treatment for burn wound healing, with evidence of enhanced reepithelialization and collagen deposition.
Retrospective case series: Implementation of the Wound Hygiene protocol for wound healing - Woundsinternational.com
Article by Harikrishna K Ragavan Nair, Hui-Hsiu Chang, Jixue Liu, Kazutaka Soejima et al. (Wounds).
This retrospective case study series highlights successful application of the Wound Hygiene protocol in treating hard-to-heal, chronic wounds by healthcare practitioners across the Asia-Pacific region. Cases include complex wounds such as bilateral lower-limb ulceration associated with verrucous non-haemorrhagic elephantiasis and necrotising fasciitis.
Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome - Frontiersin.org
Article by Jie Zhou, Zengkun Sun, Xiaoru Wang, Shouguo Wang et al. (China - Front. Bioeng. Biotechnol.).
The authors' findings are of significant implications for understanding the mechanism of skin wound healing, as well as for the treatment and clinical applications of skin wounds, especially aging skin.
Smart bandage with multi-sensor system for wound healing and microenvironment monitoring - Sciencedirect.com
Abstract by Leilei Ji, Yuqin Xiao, Kaige Xu, Xiaozhuo Wu et al. (China, Canada, USA - Chemical Engineering Journal).
Ineffective Care: Healing May Not be the Goal of Wound Debridement - Einpresswire.com
The type of debridement should align with the treatment goals when managing a patient with a serious Stage III or Stage IV decubitus ulcer. Salvageable patients who desire flap closure require a debridement designed to get the wound ready for reconstructive surgery. That is best provided by the plastic surgeon.
The CEAP Classification: What You Should Know - Woundsource.com
In this blog, learn how the CEAP classification system is defined and how it can be used by clinicians to identify patients at risk for VLU formation and better define the state of existing VLUs.
Wound Care Collaborative Community Expert Panel Shares 12 Consensus Recommendations - Woundsource.com
Article by Kirra Fedyszyn.
How can the world of wound care better embrace innovation, improve patient care, and overcome challenges? Consensus recommendations from a recently published article outline experts’ thoughts on these issues.
Burn Progression in Human Skin - A Review of Current Knowledge and Opportunities for Future Research - PubMed
Abstract by Mary Junak and Angela Gibson (Madison, USA - J Burn Care Res.).
The role of cytokines in wound healing: from mechanistic insights to therapeutic applications - Explorationpub.com
Article by Rachel Si-Yin Wong, Timothy Tan, Alexander Shao-Rong Pang and Dinesh Kumar Srinivasan (Singapore - Exploration of Immunology).
This review examines the multifaceted roles of cytokines in wound healing and discusses recent advancements in the therapeutic application of cytokine modulation for improved wound care outcomes. Despite significant advancements in improving the specificity of cytokine therapies, further research is needed to focus on targeting downstream signaling pathways or specific receptors to minimize the adverse effects associated with these treatments.
Innovative sensor technology could revolutionize wound healing tracking - New-medical.net
A major challenge in self-powered wearable sensors for health care monitoring is distinguishing different signals when they occur at the same time. Researchers from Penn State and China's Hebei University of Technology addressed this issue by uncovering a new property of a sensor material, enabling the team to develop a new type of flexible sensor that can accurately measure both temperature and physical strain simultaneously but separately to more precisely pinpoint various signals.
Nutritional Interventions for Pressure Ulcer Prevention in Hip Fracture Patients: A Systematic Review and Meta-Analysis of Controlled Trials - Mdpi.com
Article by Jose M. Moran, Laura Trigo-Navarro, Esther Diestre-Morcillo, Elena Pastor-Ramon and Luis M. Puerto-Parejo (Spain - Nutrients).
The incidence and evolution of pressure ulcers can be improved by oral dietary supplementation in patients who have undergone hip fracture surgery. Accordingly, the authors propose that oral nutritional supplementation should be considered an essential component of comprehensive post-hip-fracture care.
Effects of vitamin D3 supplementation on the recovery of hospitalized burn patients: a randomized double-blind controlled trial - Biomedcentral.com
Article by Elahe Ghadimi, Roozbeh Rahbar, Elham Jafarzade and Anahita Mansoori (Ahvaz, Iran - BMC Nutrition).
Supplementation with vitamin D at doses of 1000 and 3000 IU/day improved wound healing and decreased scar thickness as well as exogenous insulin requirements. Overall, at 3000 IU/day, better results were achieved than at 1000 IU/day.
Wound Healing, Antioxidant, and Antiviral Properties of Bioactive Polysaccharides of Microalgae Strains Isolated from Greek Coastal Lagoons - Mdpi.com
Article by Gabriel Vasilakis, Sofia Marka, Alexandros Ntzouvaras, Maria-Eleftheria Zografaki et al. (Athens, Greece - Marine Drugs).
14 new microalgae strains of the genera Tetraselmis, Dunaliella, and Nannochloropsis, isolated from Greek coastal lagoons were analyzed to quantify and characterize their polysaccharide content.
Vitamin D and keloids: a new path to treatment - Newswise.com
A study published in Burns & Trauma has shed light on how inhibiting CYP24A1, an enzyme involved in vitamin D metabolism, affects keloid keratinocytes.
Arthritis ointment diacerein heals chronic wounds in girl with RDEB - Epidermolysisbullosanews.com
Article by Steve Bryson.
A topical ointment containing diacerein, an arthritis medication, promoted wound healing in a 5-year-old girl with hard-to-treat recessive dystrophic epidermolysis bullosa, a case study reports.
Impact of the Negative Pressure Wound Therapy System (PICO 7 Smith and Nephew) on Surgical Site Infections in High-Risk Patients Undergoing Elective Colorectal Resections and Emergency Laparotomy - PubMed
Abstract by Abhijeet Beniwal and Isha Karwasra (Southampton, UK - Cureus).
Wound Dressing Materials: Bridging Material Science and Clinical Practice - Mdpi.com
Article by Maria Pia Ferraz (Porto, Portugal - Applied Sciences).
This review aims to analyze the development of cost-effective, environmentally friendly, and versatile wound dressings that meet diverse clinical needs. This synthesis of material science and antimicrobial strategies offers a foundational resource for advancing wound care solutions.
Evaluation of the antibacterial properties of four bioactive biomaterials for chronic wound management - Tandfonline.com
Abstract by Sarah Fakher and David Westenberg (Rolla, USA - Future Microbiology).
Does Wound Location Affect Healing? - Specialtywoundcare.com
Wound healing is a complex and multifactorial process that can be influenced by various elements, from the type of injury to the overall health of the individual. One crucial yet often overlooked factor in the healing process is the location of the wound. Indeed, research and clinical practice both indicate that the site of a wound can significantly affect its healing time, quality, and overall outcome. Whether it is a minor scrape or a major surgical incision, the location of the wound plays a vital role in determining how well and how quickly the body can repair itself.
Impacts of stem cells from different sources on wound healing rate in diabetic foot ulcers: a systematic review and meta-analysis - Frontiersin.org
Article by Le Tong, Lin Tang, Bangli Tang and Jianna Zhang (China - Front. Genet.).
The authors' study suggested that stem cells from different sources showed potential in promoting wound healing in DFU, although with some variation in effectiveness. Despite some publication bias and moderate heterogeneity, the overall therapeutic effect remained positive. These findings indicated that stem cell therapy might influence the progression of DFU.
Next-Generation Biomaterials for Wound Healing: Development and Evaluation of Collagen Scaffolds Functionalized with a Heparan Sulfate Mimic and Fibroblast Growth Factor 2 - Mdpi.com
Article by Merel Gansevoort, Sabine Wentholt, Gaia Li Vecchi, Marjolein de Vries et al. (The Netherlands - JFB).
The authors present a novel approach where porous type I collagen scaffolds were covalently functionalized with ReGeneRating Agent (RGTA®) OTR4120. RGTA® is a glycanase-resistant heparan sulfate mimetic that promotes regeneration when applied topically to chronic wounds.
Topical ABT-263 treatment improves wound healing in aging skin - News-medical.net
A drug called ABT-263 can significantly improve wound healing in aging skin. When applied directly to the skin of older mice, ABT-263 helps clear out old, damaged cells, known as senescent cells, and speeds up the skin's ability to heal after injury. This finding could lead to new treatments for slow-healing wounds in older adults, especially for post-surgical recovery and chronic wound care.
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway - Dovepress.com
Article by Xiajie Huang, Jie Liu, Xiaomei Wu, Yangzhou Mo et al. (China - Journal of Inflammation Research).
The findings showed that TTT enhanced the production of growth factors that in turn activated EPC proliferation and migration through the Ras/Raf/MEK/ERK pathway, ultimately contributing to angiogenesis and DFU healing.
New Perspectives of Hydrogels in Chronic Wound Management - Mdpi.com
Article by Adina Alberts, Andreea Gabriela Bratu, Adelina-Gabriela Niculescu and Alexandru Mihai Grumezescu (Bucharest, Romania - Molecules).
This paper presents hydrogel technology’s latest developments, emphasizing drug-loaded and stimuli-responsive types and underscoring how these advanced formulations greatly improve therapy outcomes by enabling dynamic and focused reactions to the wound environment.
Does Depression Slow Wound Healing? - Specialtywoundcare.com
Mental health plays a significant role in the wound healing process. Depression, in particular, can lead to slower healing times, increased infection risk, and poorer recovery outcomes. By acknowledging the relationship between mental health and wound healing, healthcare providers can develop more comprehensive care plans that address both physical and psychological health.
Red light-emitting diode on skin healing: an in vitro and in vivo experimental study - Sciencedirect.com
Article by Tuany R. Schmidt, Belkiss C. Mármora, Fernanda T. Brochado, Lucas Gonçalves et al. (Brazil, Anais Brasileiros de Dermatologia).
LED therapy expedites cutaneous healing in the experimental model, primarily modulating inflammation and enhancing antioxidant activity.
The Influence of Basil and Cinnamon Essential Oils on Bioactive Sponge Composites of Collagen Reinforced with Hydroxyapatite - Mdpi.com
Article by Alina Robu,Madalina Georgiana Albu Kaya, Aurora Antoniac, Durmuș Alpaslan Kaya et al. (Bucharest, Romania - Materials).
The authors' results highlight the dressings’ enhanced antimicrobial properties, mechanical strength, and controlled degradation, making them promising candidates for advanced wound healing.
Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling - Mdpi.com
Article by Fei Ran, Kailang Mu, Lingli Zhou, Leqiang Peng et al. (Guiyang, China - Gels).
The authors' findings provide new research directions for addressing immune imbalance and angiogenesis defects in diabetic wound healing and lay a scientific foundation for the optimization and application of chronic wound treatment strategies.
Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective - PubMed
Abstract by Zahra Sadat Razavi, Shahrzad Aliniay Sharafshadehi, Mohammad Hasan Yousefi, Fatemeh Javaheri et al. (Iran - Arch Dermatol Res.).
Nanoflower-coated bandages could improve wound care and fight infections - News-medical.net
A carnation-like nanostructure could someday be used in bandages to promote wound healing. Researchers report in ACS Applied Bio Materials that laboratory tests of their nanoflower-coated dressings demonstrate antibiotic, anti-inflammatory and biocompatible properties. They say these results show these tannic acid and copper(II) phosphate sprouted nanoflower bandages are promising candidates for treating infections and inflammatory conditions.
Nanomedicine and Its Role in Surgical Wound Infections: A Practical Approach - Mdpi.com
Article by Malak Bentaleb, Mohammed Abdulrahman and Marcelo A. F. Ribeiro Jr (UAE, USA - Bioengineering).
Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise of antibiotic-resistant pathogens, it is crucial to develop new innovative wound materials to manage surgical wound infections using methods that facilitate drug delivery agents and rely on materials other than antimicrobials. Nanoparticles, in particular, have captured researchers’ interest in recent years due to their effectiveness in wound care.
Plasma-Activated Water Improve Wound Healing in Diabetic Rats by Influencing the Inflammatory and Remodelling Phase - Mdpi.com
Article by Jovana Rajić, Nevena Grdović, Anđelija Marković, Nikola Škoro et al. (Belgrade, Serbia - IJMS).
PAW treatment affects wound healing by reducing the inflammatory response and influencing extracellular matrix turnover, suggesting that it has great potential to accelerate the healing of diabetic wounds.
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing - Biomedcentral.com
Article by Enyou Jin, Yusheng Yang, Shengjie Cong, Dengke Chen et al. (China - Journal of Nanobiotechnology).
The authors' GelMA-DAS-Lemon Exosomes hydrogel (GelMA/DAS/Exo hydrogel) patch represents a potentially valuable option for repairing diabetic wounds in clinical applications.
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