Hungarian Wound Care Society

Mechanism and Application of Biomaterials Targeting Reactive Oxygen Species and Macrophages in Inflammation - Mdpi.com
Article by Mengxuan Yu, Shouli Wang and Doudou Lin (Suzhou, China - IJMS). The application of biomaterials in the treatment of inflammatory illnesses has grown in recent years. A variety of biomaterials can be implanted either by themselves or in conjunction with other bioactive ingredients and therapeutic agents. The mechanisms of action and therapeutic applications of well-known anti-inflammatory biomaterials are the main topics of this article.

Wound infection: diagnosis, treatment and prevention - Nhs.uk
Abstract by Alexandra Bishop (Plymouth, England - Nursing Standard).

The Role of Linoleic Acid in Skin and Hair Health: A Review - Mdpi.com
Article by Xi Wang, Yan Jia and Huaming He (Beijing, China - IJMS). This review aims to discuss the function of linoleic acid (LA, 18:2, ω-6), an essential fatty acid, in skin health and hair growth.

Harnessing Mesenchymal Stromal Cells for Advanced Wound Healing: A Comprehensive Review of Mechanisms and Applications - Mdpi.com
Article by Khrystyna Nasadiuk,Tomasz Kolanowski, Cezary Kowalewski, Katarzyna Wozniak et al. (Poland - IJMS). This review explores the current landscape of MSC application, focusing on preclinical and clinical data across chronic wounds, diabetic ulcers, burns, non-union bone fractures, lower extremity venous ulcers, pressure ulcers, and genetic skin conditions like epidermolysis bullosa.

Clinically validated classification of chronic wounds method with memristor-based cellular neural network - Nature.com
Article by Jacopo Secco, Elisabetta Spinazzola, Monica Pittarello, Elia Ricci and Fabio Pareschi (Italy - Scientific Reports). This work aims to describe in depth the technology and the computational techniques that have been implemented, and to demonstrate reliability in automatically identifying, classifying through internationally accepted clinical scales and measuring such wounds, that peaked to over a 90% of accuracy.

Dermal white adipose tissue: A new modulator in wound healing and regeneration - Researchgate.net
Article by Zhongyu Wu, Zhanqi Wang, Tao Chen, Dongyang Wang et al. (China - Regenerative Therapy). This review highlights the regulatory potential of dWAT in modulating wound healing processes and presents it as a target for developing therapeutic strategies aimed at reducing scarring and enhancing regenerative outcomes in skin-related disorders.

Marine collagen in advanced wound dressing technologies: Innovations and applications for healing - Ekb.eg
Article by Habiba A. Abdelrahman and Nihal El Nahhas (Alexandria, Egypt - Microbial Biosystems). The manufacturing of scaffolds from various marine sources has demonstrated a significant effect on wound healing acceleration than normal wound dressings. Different types of scaffolds, including surgically applied scaffolds, sponges, and hydrogel scaffolds loaded with drugs, have also been explored for their effectiveness. The scaffolds loaded with the drug have the highest wound-healing acceleration rate.

Wound, Pressure Ulcer, and Burn Guidelines-5: Guidelines for the management of lower leg ulcers and varicose veins, second edition - Wiley.com
Article by Takaaki Ito, Ryuichi Kukino, Yasuko Sarayama, Miki Tanioka et al. (Japan - The Journal of Dermatology). The guidelines were drafted by the Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee delegated by the Japanese Dermatological Association and intend to facilitate physicians' clinical decisions in preventing, diagnosing and management of lower leg ulcers and varicose veins. They updated all sections by collecting documents published since the publication of the first edition. In particular, they added clinical question 8 (CQ8), which addresses endovenous laser ablation for varicose veins, a procedure that became covered by the Japanese national health insurance after the writing of the first edition, and endovenous radiofrequency ablation, which became covered by national health insurance in 2014.

Nanotherapeutic and Nano–Bio Interface for Regeneration and Healing - Mdpi.com
Article by Rajiv Kumar, Chinenye Adaobi Igwegbe and Shri Krishna Khandel (India, Nigeria, Poland - Biomedicines). This review provided insights into the cellular and molecular mechanisms of wound healing and regeneration, emphasizing the significance of interdisciplinary approaches and innovative technologies in advancing regenerative therapies. Through harnessing the potential of nanoparticles, bio-mimetic matrices, and scaffolds, regenerative medicine offers promising avenues for restoring damaged tissues with unparalleled precision and efficacy.

Clinical Research from Great Debates and Updates in the Diabetic Foot - Woundsource.com
Article by Richard Benskin. Researchers share emerging findings they presented at the recent Great Debates and Updates in the Diabetic Foot conference.

More Clinical Research Highlights from Great Debates and Updates in the Diabetic Foot - Woundsource.com
Article by David G. Armstrong, Adam L. Isaac, Dustin L. Kruse, Charles M. Zelen et al. What research was top of mind during this recent conference? These abstracts highlight just some of the new thinking in wound care.

Skin Stretching Techniques: A Review of Clinical Application in Wound Repair - Lww.com
Article by Tian Yang, Zhixiang Tan, Chen Xuejie, Fang Wang et al. (Wuhan, China - Plastic & Reconstructive Surgery-Global Open) Skin stretch techniques emerge as a promising approach for managing large-area wounds, offering the advantage of achieving primary healing without compromising surrounding healthy tissue. However, to optimize its clinical application, further research is warranted, particularly in addressing challenges related to precise stretching and infection management.

Additional Research Insights on Diabetic Wound Healing - Woundsource.com
Article by Ian Barron and H. David Gottlieb. 67% of DFUs without exposed bone or tendon, treated with weekly fish skin graft sheets alongside standard care, achieved complete closure compared to only 32% in the group treated without fish skin grafts. These promising outcomes suggest that fish skin grafts hold significant promise as an adjunctive therapy for enhancing DFU healing.

Physiotherapy Intervention in the Treatment of Venous Ulcers: Results from a Delphi Panel - Mdpi.com
Article by Sabrina Medeiros, Alexandre Rodrigues and Rui Costa (Portugal, JVD). Physiotherapy may be beneficial as an adjuvant therapy alongside specific local treatments for venous ulcers. Therapeutic exercise and compression therapy are commonly utilized interventions that could support overall treatment outcomes.

Platelet-Rich Plasma in Diabetic Foot Ulcer Healing: Contemplating the Facts - PubMed
Abstract by Jacob Smith and Vikrant Rai (Pomona, USA - Int J Mol Sci.).

Carbonized Plant Powder Gel for Rapid Hemostasis and Sterilization in Regard to Irregular Wounds - Mdpi.com
Article by Zhong Liu, Shaolei Ding, Guodong Zhang, Bingyu Yan et al. (Qingdao, China - Nanomaterials). In this study, authors designed a new composite functional dressing consisting of traditional Chinese herb carbonized plant powder (CPP) and a polyacrylic acid (PAA)/polyethylenimine (PEI) gel. The rapid gelation of the dressing within 6–8 s allowed the gel to be firmly attached to an irregularly shaped wound surface and avoided powder detachment.

Isolation, Expansion, and Characterization of Rat Hair Follicle Stem Cells and Their Secretome: Insights into Wound Healing Potential - Mdpi.com
Article by Patrícia Sousa, Bruna Lopes, Ana Catarina Sousa, André Coelho et al. (Portugal, Italy - Biomedicines). The authors' findings highlight the potential of these cells as a valuable cell source for skin regeneration applications. They contribute to advancing our understanding of stem cell applications in regenerative medicine and hold promise for therapeutic interventions in various clinical contexts, aligning with broader research on the diverse capabilities of hair follicle stem cells.

Placental Allograft: A Cost-Effective Option for Reconstruction of Cutaneous Defects Following Mohs Surgery - Hmpgloballearningnetwork.com
The purchase of the placental allografts accounted for 76.4% of total reconstruction costs, on average, as treatment with dHACM helped patients avoid the costs of postoperative complications.

Some aging cells heal wounds, others cause harm: Study shows how to distinguish between the two - Medicalxpress.com
Lengthening life by eliminating old, inflammatory cells is a tantalizing idea, but anti-aging researchers suspect it's oversimplified. Now, University of Connecticut researchers confirm in an article published in the Nov. 13 issue of Nature Aging that aged, inflammatory cells are diverse, and some play important roles in the body.

Enhanced Wound Healing and Autogenesis Through Lentiviral Transfection of Adipose-Derived Stem Cells Combined with Dermal Substitute - Mdpi.com
Article by Shiqi Wang, Dinghui Gao, Mingyu Li, Qian Wang et al. (Nanjing, China - Biomedicines). Integrating DGTM factor-transfected ADSCs with dermal substitutes represents a novel strategy for enhancing the healing of full-thickness wounds. Further research and clinical trials are warranted to optimize and validate this innovative approach for broader clinical applications.

Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment - Mdpi.com
Article by Juan Cao, Bo Wu, Ping Yuan, Yeqi Liu and Cheng Hu (Chengdu, China - Pharmaceutics). The review identifies key challenges, including limited mechanical strength, drug-loading efficiency, and lack of standardization, while proposing strategies to overcome these issues.

A Beneficial Bacterium Promotes Wound Healing: New Insights into the Wound Microbiome - Microbiota-ism.com
Chronic wounds, which affect approximately 2% of the global population, represent a major healthcare challenge, often leading to severe pain, mental health issues, and reduced quality of life. However, a new study offers hope, revealing that a bacterium found in the wound microbiome, Alcaligenes faecalis, can accelerate wound healing. Researchers at the University of Pennsylvania discovered that this environmental, non-pathogenic bacterium secretes factors that enhance wound repair. The findings highlight the potential for microbiota-based therapies.

Geometry and Mechanics of Wounded Tissue Determine Healing Outcomes - Ncbs.res.in
A recent study has uncovered a surprising insight into the mechanics of wound healing: the closure of wounds is subject to geometric limitations in the absence of tissue proliferation. In other words, no matter how large or small the wound, there are certain physical properties of tissues that set boundaries on how much the wound can heal.

Healing of diabetic neuropathic foot ulcers receiving standard treatment in randomised controlled trials: A random effects meta-analysis - PubMed
Abstract by Tyler L Coye, Miguel Bargas Ochoa, Alejandro Zulbaran-Rojas, Bernado Martinez Leal et al. (USA - Wound Repair Regen.).

Wound care: How to prevent scarring - Health.osu.edu
Article by Kevin Quinn. Scarring, whether on the skin or anywhere else, is a result of the body’s natural healing process following an injury or wound. Proper wound care, like keeping the area clean and protected, can help make scars less noticeable over time.

Antimicrobial Mixture Based on Micronized Kaolinite and Ziziphora Essential Oil as a Promising Formulation for the Management of Infected Wounds - Mdpi.com
Article by Aigerim A. Karaubayeva,Tolkyn Bekezhanova, Karlygash Zhaparkulova, Katarzyna Susniak et al. (Kazakhstan, Poland - IJMS). This is the first documented formulation combining KAO and ZEO, demonstrating significant antimicrobial properties along with the ability to stimulate collagen production in fibroblasts.

3D Printing in Wound Healing: Innovations, Applications, and Future Directions - Cureus.com
Article by Rahul A. Sachdeo, Chitra Khanwelkar and Amol Shete (Karad, India). This review explores the current state of 3D printing in wound care, its challenges, and the future potential of these innovative technologies.

Nano-Delivery Revolution: Harnessing Mesenchymal Stem Cell-Derived Exosomes’ Potential for Wound Healing - Mdpi.com
Article by Pawan Kumar Raghav and Zoya Mann (USA, India - Biomedicines). The exploration of cell-free therapy in this review holds promising implications for advancing wound-healing strategies.

An Evidence-Based, Sustainable Solution for Wound Management in Low-Resource Settings: Part 1 - Woundsource.com
Article by Linda Benskin and Richard Benskin. The Benskin Research Group has been working since 1999 to develop a safe, effective, affordable, available, and acceptable wound management method to teach lay health care providers in low-resource settings. This article summarizes these 20+ years of research, culminating with testing Available Technology Dressings (ATDs), a very specific sustainable moist dressing technique which can be taught to patients and lay health care providers.

Case Report: Wound Care of a Diabetic Foot Ulcer - PubMed
Abstract by Tom Wynn and Chad Thompson (Ohio, USA - Int J Pharm Compd.).

Exploring the wound healing potential of dietary nitrate in diabetic rat model - PubMed
Abstract by Xiaodan Hu, Haoyue Xu, Lingxue Bu, Jian Sun et al. (Qingdao, China - Front Physiol.).

Enhancing Photothermal Therapy for Antibiofilm Wound Healing: Insights from Graphene Oxide-Cranberry Nanosheet Loaded Hydrogel in vitro, in silico, and in vivo Evaluation - Tandfonline.com
Article by Sammar Fathy Elhabal, Saeed AS Al-Zuhairy, Mohamed El-Nabarawi, Mohamed Fathi Mohamed Elrefai et al. (Egypt, Jordan, Iraq - International Journal of Nanomedicine). The PVA/CH/GO-CR hydrogel exhibits multifunctional properties that enhance wound healing ulcers. Its superior mechanical, antibacterial, and anti-inflammatory properties and ability to promote angiogenesis make it a promising candidate for effective wound management in diabetic patients.

Use of Continuous Topical Oxygen Therapy in Combination to Optimize the Chronic Wound Environment Prior to Cellular, Acellular, and Matrix-Like Product Application: A Retrospective Case Series - Hmpgloballearningnetwork.com
Article by Naz Wahab, Windy Cole and Emma Woodmansey (USA, UK). Wound healing should be approached in an algorithmic manner, starting with wound bed optimization. In this patient cohort continuous topical oxygen therapy proved to be an effective way to improve the quality of the wound bed, in addition to the standard cleansing and debridement, prior to cellular, acellular, and matrix-like product application. The authors believe that this combination of topical methods might have synergistic effects and improve wound healing, and the results of this study support this assumption.

Hospital-Acquired Pressure Ulcers and Long-Term Motor Score Recovery in Patients With Acute Cervical Spinal Cord Injury - PubMed
Abstract by Marcel A Kopp, Felix W Finkenstaedt, Oliver Schweizerhofs, Ulrike Grittner et al. (Germany, USA - JAMA Netw Open).

Wound Healing Complications After Sternotomy - Causes, Prevention, and Treatment - A New Look at an Old Problem - Mdpi.com
Article by Agata Jęczmyk, Sebastian Krych, Małgorzata Jekiełek, Michał Jurkiewicz et al. (Poland - JCM). The described actions are aimed at avoiding the most serious complication associated with a high mortality rate in the form of mediastinitis. The therapeutic procedures are strictly dependent on the degree of tissue involvement and the presented clinical manifestation.

Therapeutic activities of honey in wound care: a narrative review - Iop.org
Article by K. Khairan, M. Mudatsir, M. Diah, S. Rizal et al. (Indonesia). This paper clarifies the therapeutic properties of honey, and their mechanism of action as an antimicrobial agent, immunological modulator, and physiological mediator in wound healing. This paper also amplifies the main compounds responsible for the wound care capacity.

Bioengineered Extracellular Vesicle Hydrogel Modulating Inflammatory Microenvironment for Wound Management - Mdpi.com
Article by Yunfei Mu, Liwen Ma, Jia Yao, Dan Luo and Xianguang Ding (Nanjing, China - IJMS). The authors' promising findings suggest that this bioactive hydrogel patch could serve as a versatile, practical solution for chronic wound management, providing an adaptable platform that addresses both the biological and logistical needs of wound care in clinical settings.

Imperfect wound healing sets the stage for chronic diseases - Science.org
Abstract by Paul Martin, Carlos Pardo-Pastor, R. Gisli Jenkins and Jody Rosenblatt (UK, Spain - Science).

The Future of Wound Care: Why Nanofibers are Key to Accelerated Healing - Azonano.com
According to a report published by Markets and Markets, the worldwide wound care market is predicted to rise to $27 billion by 2025. Amid this growing ecosystem, conventional approaches to wound care are being dominated by emerging technologies.

Incision care and dressing selection in obstetrics and gynaecology: Findings from an international meeting of obstetricians and gynaecologists - Woundsinternational.com
Article by Kylie Sandy-Hodgetts, Wang Junjie, Chia Yin Nin, Krasean Panyakhamlerd et al. This report highlights the findings of a meeting of obstetricians and gynaecologists based in the Asia-Pacific (APAC) region, during which incision care and dressing selection in obstetrics and gynaecology were discussed. The meeting was held in April 2024 and was chaired by Associate Professor Kylie Sandy-Hodgetts. (Australia).

Revolutionising shift in advanced wound healing therapies: nanoengineered herbal gels - PubMed
Abstract by Rahul Singh, Jatin Kumar, Satyendra Kumar Rajput et al. (India - Nat Prod Res.).

ASU study uses new biomaterials for wound healing - Asu.edu
Article by Richard Harth. In a new study, researchers from Arizona State University explore the wound-healing process in detail, focusing on the role of histamine — a natural chemical that helps coordinate the body’s repair process. Histamine is involved in allergic reactions, where it causes symptoms such as itching, swelling and runny nose. However, histamine is also essential for regulating the immune system, managing inflammation and aiding wound healing.

Understanding the physiology of wound healing and holistic wound assessment - PubMed
Abstract by Carole Young (Cambridge, UK - Nurs Stand.).

Enhancing Photothermal Therapy for Antibiofilm Wound Healing: Insights from Graphene Oxide-Cranberry Nanosheet Loaded Hydrogel in vitro, in silico, and in vivo Evaluation - Dovepress.com
Article by Elhabal SF , Al-Zuhairy SAS , El-Nabarawi M, Mohamed Elrefai MF et al. (Egypt, Iraq, UAE). The PVA/CH/GO-CR hydrogel exhibits multifunctional properties that enhance wound healing ulcers. Its superior mechanical, antibacterial, and anti-inflammatory properties and ability to promote angiogenesis make it a promising candidate for effective wound management in diabetic patients.

Randomized Clinical Evaluation of the Healing Activity of Green Propolis Ointment in Individuals with Lower Limb Ulcers Resulting from Leprosy: Preliminary Results of a Pilot Study - Mdpi.com
Article by Cristiano da Rosa, Larissa Kaori Maquedano, Ian Lucas Bueno, Fernando Augusto Lima Marson et al. (São Paulo, Brazil - Pharmaceuticals). The findings suggest that green propolis ointment is safe, supports tissue repair and may offer cost-effective treatment benefits. Standard wound dressings are selected to support all healing stages, with an emphasis on antimicrobial action, hemostasis to reduce exudate, and pain-reducing and non-irritant properties.

Hyperbaric Oxygen Therapy Combined With Standard Wound Care Versus Standard Wound Care Alone in Patients With Diabetic Foot Ulcers: A Prospective Comparative Study - Cureus.com
Article by Aldrin L. Myrthong. Shrutika Gurav. Suresh Mahankudo, Kashif F. Ansari et al. (Mumbai, India). Adjuvant HBOT and SWC are more effective than SWC in healing the DFUs and reduction of minor amputations.

A Beneficial Bacterium Helps Wounds Heal - The-scientist.com
Article by Sneha Khedkar. A bacterium found in the wound microbiome can accelerate healing, highlighting the potential for microbiota-based wound therapies.

Current Approaches in Healing of Wounds in Diabetes and Diabetic Foot Ulcers - Sciencedirect.com
Abstract by Samrat Chauhan, Rishabh Chalotra, Akshay Rathi, Monika Saini et al. (India - Current Bioactive Compounds).

Targeted Antibacterial Endolysin to Treat Infected Wounds on 3D Full-Thickness Skin Model: XZ.700 Efficacy - Mdpi.com
Article by Marisa Meloni, Bob de Rooij, Ferdinand W. Janssen, Francesca Rescigno and Bernadette Lombardi (Italy, Switzerland - Pharmaceutics). The preclinical in vitro infected wound model on FT-kin showed interesting applications to assess the repair efficacy of dermo-pharmaceutical and cosmetic formulations.