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News from the field of wound care and wound healing - December, 2021

Effectiveness of negative pressure wound therapy for the wound of ileostomy closure: a multicenter, phase II randomized controlled trial - PubMed
Abstract by Koichiro Kojima, Mayu Goto, Yasuo Nagashima, Yoko Saito, Masaya Kawai, Shihori Takebe, Akiko Egawa, Mitsuko Tanba, Kazue Ishikawa, Hiroyoshi Matsuoka, Tadahiko Masaki, Eiji Sunami, Norihiko Ohura, Koji Teruya, Ken Eto, Keijiro Nozawa, Kazuhiro Sakamoto and Kimihiko Funahashi (Tokyo, Japan - BMC Surg.).


Severe Acne: New Hope with Radiotherapy - Eutorbonews.com
Dr. Sanusi Umar, a dermatologist and hair transplant specialist at Dr. U Hair and Skin Clinic in Manhattan Beach, Calif., recently published a study in the Journal of the American Academy of Dermatology Case Reports that outlines the role of radiation as a therapeutic tool in acne keloidalis nuchae (AKN).


Electrospun Polysaccharide Scaffolds: Wound Healing and Stem Cell Differentiation - PubMed
Abstract by G U Preethi, B S Unnikrishnan, J Sreekutty, M G Archana, Mohan Deepa, Pillai K Raveendran and T T Sreelekha (Thiruvananthapuram, India - J Biomater Sci Polym Ed.).


Infection Probability Index: Implementation of an Automated Chronic Wound Infection Marker - Mdpi.com
Article by Franziska Schollemann, Janosch Kunczik, Henriette Dohmeier, Carina Barbosa Pereira, Andreas Follmann and Michael Czaplik (Aachen, Germany - JCM). The number of people suffering from chronic wounds is increasing due to demographic changes and the global epidemics of obesity and diabetes. Innovative imaging techniques within the field of chronic wound diagnostics are required to improve wound care by predicting and detecting wound infections to accelerate the application of treatments. For this reason, the infection probability index (IPI) is introduced as a novel infection marker based on thermal wound imaging.


Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats - Hindawi.com
Article by Ramezani Ali, Najafpour Alireza, Farahpour Mohammad Reza and Mohammadi Rahim (Urmia, Iran - BioMed Research International). Accelerated healing of diabetic wounds infected with MRSA showed that local application of cinnamon nanoparticles along with HAMLET sensitization on S. aureus-infected wound could be taken into consideration.


M2 Macrophage-Derived Concentrated Conditioned Media Significantly Improves Skin Wound Healing - Springer.com
Abstract by Cininta Savitri, Jae Won Kwon, Valeryia Drobyshava, Sang Su Ha and Kwideok Park (Tissue Engineering and Regenerative Medicine).


In vitro fibroblasts viability and migration stimulation of Acalypha indica: an insight on wound healing activity - Researchgate.net
Article by Ammar Mahmoud Ibrahim, Mariani Abdul Hamid, Rama Ali Althiab, Amir Husni Mohd Sharif and Razauden Mohamed Zulkifi (Skudai, Malaysia - Future Journal of Pharmaceutical Sciences). This study provided evidence for A. indica to have great wound healing potential. The finding builds the scientifc background in future to utilise the high antioxidant activity of A. indica and its ability to stimulate fibroblasts migration and proliferation for further applications.


Nonwoven Textiles from Hyaluronan for Wound Healing Applications - Mdpi.com
Article by Jolana Kubíčková, Tomáš Medek, Jarmila Husby, Jana Matonohová, Hana Vágnerová, Lucie Marholdová, Vladimír Velebný and Josef Chmelař (Donny Dobrucci, Czech Republic - Biomolecules). The beneficial effect of hyaluronan in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds.


Tissue Engineering-Based Strategies for Diabetic Foot Ulcer Management - PubMed
Abstract by Alvis Chiu, Dhavan Sharma and Feng Zhao (Texas, USA - Adv Wound Care (New Rochelle)).


Does Probiotic Consumption Enhance Wound Healing? A Systematic Review - Mdpi.com
Article by Camille Togo, Ana Paula Zidorio, Vivian Gonçalves, Patrícia Botelho, Kenia de Carvalho and Eliane Dutra (Brasilia, Brazil - Nutrients). The positive or neutral results observed do not generate strong evidence regarding the effectiveness of probiotics for wound healing. However, they suggest a promising field for future clinical research where the probiotic strains used, type of wounds, and target population are controlled for.


Does Wound Management Technique Impact Surgical Site Infection in Open Emergency Colon Procedures? - Mdpi.com
Abstract by Justin J Turcotte, Andrea Boord, Lauren Antognoli, J Robert Klune and Cristina B Feather (Annapolis, USA - Am Surg.).


A nano phototheranostic approach of toluidine blue conjugated gold silver core shells mediated photodynamic therapy to treat diabetic foot ulcer - Nature.com
Article by Farheen Akhtar, Asad U. Khan, Bushra Qazi, Senthilguru Kulanthaivel, Prashant Mishra, Kafil Akhtar and Asif Ali (India - Scientific Reports). The authors conclude that TBO–chit–Au–AgNPs mediated PDT is a promising anti-bacterial therapeutic approach which leads to a synergistic healing of DFU caused by MDR bacterial strains.


Negative Pressure Wound Therapy in Facilitating Wound Healing after Surgical Decompression for Metastatic Spine Disease - PubMed
Abstract by Benjamin M Vidalis, Somtochukwu I Ngwudike, Martin G McCandless and Muhammad O Chohan (USA - World Neurosurg.).


Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial - PubMed
Abstract by José María García-Sánchez, Vicente Mirabet Lis, Alejandro Ruiz-Valls, Aranzazu Pérez-Plaza, Pilar Sepúlveda Sanchis and María Dolores Pérez-Del-Caz (Valencia, Spain - Burns).


Topical Oxygen Therapy for Wound Healing: A Critical Evaluation - PubMed
Abstract by Nicole K Cates and Paul J Kim (USA - Surg Technol Int.).


Ignorance of Diabetes may lead to diabetic foot and amputation - Financialexpress.com
Article by Ashu Rastogi. Every 5 to 6 minutes, it is estimated that 10 to 12 people would have lost their limbs due to Diabetic foot ulcers.


Use of a Novel Silicone-Acrylic Drape with Negative Pressure Wound Therapy in Four Patients with Periwound Skin Breakdown - PubMed
Abstract by Emily Greenstein and Nancy Moore (Fargo, USA - Wounds).


Application of Self-Adhesive Soft Silicone Common Foam Dressing in Reducing Intraoperative Pressure Ulcers in Elderly ICU Patients - Nig.hov
Article by Fen Wang, Xiaoqing Gan, Xu Zhou, Yanbing Shen, Ruiying Zhang, Sun Hong, Dan Tang, Sha Li and Zeya Shi (Changsha, China - Comput Math Methods Med.). The authors found that the Meipicang dressing can reduce the incidence of pressure ulcers in ICU patients with severe ICU and improve the comfort and nursing satisfaction of elderly ICU patients with severe ICU, which is worthy of promotion.


Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies - Nature.com
Article by Nessma A. EL-Zawawy and Mahy M. Mona (Tanta, Egypt - Scientific Reports). The authors' results suggested that mucus extracts of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent.


Prolonged postoperative antibiotic administration reduces complications after medial thigh lift - Tandfonline.com
Abstract by J. Weber, Z. Kalash, F. Simunovic and B. Bonaventura (Freiburg, Germany - Journal of Plastic Surgery and Hand Surgery).


The Personal Impact of Daily Wound Care for Hidradenitis Suppurativa - PubMed
Abstract by Suzanne Moloney, Barry M McGrath, Davood Roshan and Georgina Gethin (Galway, Ireland - Dermatology).


The reliability of the Wagner Scale for evaluation the diabetic wounds: A literature review - PubMed
Abstract by Milad Jalilian and Samira Shiri (Kermanshah, Iran - Diabetes Metab Syndr.).


Hyperbaric Oxygen Therapy for Reconstructive Urology Wounds: A Case Series - Dovepress.com
Article by Mendy Hatibie Oley, Maximillian Christian Oley, Ari Astram Adhiatma Iskandar, Christof Toreh, Marcella Tirsa Tulong and Muhammad Faruk (Indonesia - Research and Reports in Urology). HBOT promotes wound healing and improves graft integration in patients undergoing urological reconstructive surgery.


High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms - Mdpi.com
Article by Yasir Nazir, Pichchapa Linsaenkart, Chiranan Khantham, Tanakarn Chaitep, Pensak Jantrawut, Chuda Chittasupho, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Sarana Rose Sommano, Jiraporn Tocharus, Salin Mingmalairak, Anchali Wongsa, Chaiwat Arjin, Korawan Sringarm, Houda Berrada, Francisco J. Barba and Warintorn Ruksiriwanich (Thailand, Spain - JoF). The authors' findings support that core of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.


Tissue-Engineered Skin Regenerative Units for Epidermal Keratinocytes Expansion and Wound Healing - PubMed
Abstract by Xinjian Zhang, Wen Xu and Xinlei Hu (Hangzhou, China - Med Sci Monit.).


At-Risk Patient: Surgical Site Infections - Woundsource.com
Skin is a natural barrier against infection. Despite the provision of precautions and protocols to prevent infection, any surgery or procedure that breaches the skin can lead to an infection. Infections that occur on the part of the body where the surgical procedure took place are called surgical site infections.


Clinical outcome of Maggot Debridement Therapy followed by Negative Pressure Wound Therapy for chronic hand wound with Multi-Drug Resistant Organism infection: Two cases and review of the literature - PubMed
Abstract by Zi Hao Phang, Saw Sian Khoo, Jayaletchumi Gunasagaran and Tunku Sara Tunku Ahmad (Kuala Lumpur, Malaysia - J Orthop Surg (Hong Kong)).


Effects of amniotic fluid on human keratinocyte gene expression - Implications for wound healing - PubMed
Abstract by Erika Nyman, Elvira Lindholm, Jonathan Rakar, Johan Pe Junker and Gunnar Kratz (Linköping, Sweden - Exp Dermatol.).


Physical, Psychological, and Social Outcomes in Pediatric Burn Survivors Ages 5 to 18 Years: A Systematic Review - PubMed
Abstract by Khushbu F Patel, Silvanys L Rodríguez-Mercedes, Gabrielle G Grant, Camerin A Rencken, Erin M Kinney, Amelia Austen, Carina Hou, Keri J S Brady, Jeffrey C Schneider, Lewis E Kazis and Colleen M Ryan (USA - J Burn Care Res.).


The Role of Extracellular Matrix in Skin Wound Healing - Mdpi.com
Article by Nikolai N. Potekaev, Olga B. Borzykh, German V. Medvedev, Denis V. Pushkin, Marina M. Petrova, Artem V. Petrov, Diana V. Dmitrenko, Elena I. Karpova, Olga M. Demina and Natalia A. Shnayder (Russia - JCM). This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.


The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way - Sciencedirect.com
Article by Chenbing Wang, Chenyu Chu, Xiwen Zhao, Yang Yang, Chen Hu, Li Liu, Jidong Li, Yili Qu and Yi Man (China - Bioactive Materials). All the authors' results indicated that wound healing requires the active participation of the immune process, and that A300 was a potential candidate for guided skin regeneration applications.


Role of Burn Blister Fluid in Wound Healing - PubMed
Abstract by Saurabh Gupta, Ravi K Chittoria, Vinayak Chavan, Abhinav Aggarwal, Likhitha C Reddy, Padmalakshami B Mohan, Shijina Koliyath and Imran Pathan (Puducherry, India - J Cutan Aesthet Surg.).


Closed incision negative pressure wound therapy versus conventional dressings following soft-tissue sarcoma excision: a prospective, randomized controlled trial - PubMed
Abstract by David W Shields, Nima Razii, James Doonan, Ashish Mahendra and Sanjay Gupta (Glasgow, UK - Bone Jt Open).


Far-Infrared Therapy Accelerates Diabetic Wound Healing via Recruitment of Tissue Angiogenesis in a Full-Thickness Wound Healing Model in Rats - Mdpi.com
Article by Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang and Yur-Ren Kuo (Taiwan, Singapore - Biomedicines). Treatment with the optimal dosage of FIR significantly facilitated diabetic wound healing and associated with suppressed pro-inflammatory response and increased neovascularization and tissue regeneration.


Negative-pressure wound therapy after stoma reversal in colorectal surgery: a randomized controlled trial - PubMed
Abstract by Francesco M Carrano, Annalisa Maroli, Michele Carvello, Caterina Foppa, Matteo Sacchi, Jacopo Crippa, Giuseppe Clerico, Francesca De Lucia, Elisabetta Coppola, Nadav Ben David and Antonino Spinelli (Milan, Italy - BJS Open).


Vacuum assistance therapy as compared to early reconstructive treatment in deep sternal wound infection - PubMed
Abstract by E. Hämäläinen, J. Laurikka, H. Huhtala and O. Järvinen (Tampere, Finland - Scand J Surg.).


Synthesis of environmentally benign antimicrobial dressing nanofibers based on polycaprolactone blended with gold nanoparticles and spearmint oil nanoemulsion - Sciencedirect.com
Article by Mehrez E. El-Naggar, E. S. Shalaby, A. H. Abd-Al-Aleem, M. A. Abu-Saied and Ahmed M. Youssef (Egypt - Journal of Materials Research and Technology). Utilizing the electrospinning technique, a nanofibrous scaffold of polycaprolactone (PCL) mixed with gold nanoparticles and spearmint oil nanoemulsion (SNE) was effectively produced.


Hydro-Responsive Wound Dressings for the treatment of chronic wounds: A narrative review of the clinical evidence - Linkforwoundhealing.info
Abstract by Karen Ousey, Heather Hodgson, Mark G. Rippon and Alan A. Rogers (UK - Journal of Wound Care).


Comparison of a Novel Silicone Gel Wound Dressing versus Bacitracin after Follicular Unit Extraction Hair Transplantation - Oup.com
Article by Isaac B James, David M Turer and Barry E DiBernardo (USA - Aesthetic Surgery Journal). The Stratamed wound dressing was well-tolerated in patients undergoing FUE. Stratamed may speed the healing response in the early phase of wound healing.


Macronutrient and micronutrient intake of individuals with diabetic foot ulceration: A short report - PubMed
Abstract by Rebecca Collins, Tracy Burrows, Hailey Donnelly and Peta Ellen Tehan (Callaghan, Australia - J Hum Nutr Diet.).


Statins and venous leg ulcer healing: Secondary analysis of data from a cohort of three randomised controlled trials - PubMed
Abstract by Andrew Jull, Han Lu and Yannan Jiang (Auckland, New-Zealand - Wound Repair Regen.).


Wound healing properties of a fibrin-based dermal replacement scaffold - PubMed
Abstract by Stuart Brown, Farhana Surti, Paul Sibbons and Lilian Hook (UK - Biomed Phys Eng Express).


Delayed Care During the COVID-19 Pandemic: Effects on Chronic Wound Therapy - Woundsource.com
Chronic wound care is challenging for the entire healthcare ecosystem, from clinicians to patients, and COVID-19 has only exacerbated those challenges. Patients are delaying primary care provider and wound clinician visits for ongoing guidance and therapy to reduce possible exposure to the virus. This is understandable, as many chronic wound patients are in the high-risk category if they become ill with COVID-19.


Moisture Management in Neonatal Pressure Injury Prevention: A Survey - Woundsource.com
Article by Ivy Razmus. How do nurses provide moisture management to prevent pressure injuries in neonatal patient populations? Somethings old and somethings new...


Injectable Human Hair Keratin–Fibrinogen Hydrogels for Engineering 3D Microenvironments to Accelerate Oral Tissue Regeneration - Mdpi.com
Article by Hyeon Jeong Kang, Nare Ko, Seung Jun Oh, Seong Yeong An, Yu-Shik Hwang and So Yeon Kim (Korea, IJMS). The authors observed an excellent cell viability, proliferation, and migration/cell–cell interaction, indicating that the novel KRT-FIB-injectable hydrogel is a promising platform for oral tissue regeneration with a high clinical applicability.


Polymeric Materials for Hemostatic Wound Healing - Mdpi.com
Article by Suvash Ghimire, Pritha Sarkar, Kasey Rigby, Aditya Maan, Santanu Mukherjee, Kaitlyn E. Crawford and Kausik Mukhopadhyay (Orlando, USA - Pharmaceutics). The authors highlight the necessitates the development of a unique, easy-to-use, FDA-approved hemostatic treatment that can deliver the agent in less than 30 s and stop bleeding within the first 1 to 2 min at the point of injury without application of manual pressure on the wounded area.


Preoperative contaminated wound management using short-term negative pressure wound therapy with instillation - PubMed
Abstract by James Willmore and Philip Wrotslavsky (San Diego, USA - J Wound Care).


Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury - Nature.com
Article by Daniel Jun-Kit Hu, Jina Yun, Justin Elstrott and Heinrich Jasper (San Francisco, USA - Nature Communications). The authors' findings highlight the role of non-canonical Wnt signaling in regeneration of the intestinal epithelium, and identify enteroendocrine cell-released ligands as critical coordinators of intestinal stem cell migration.


Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications - Mdpi.com
Article by Diana Serbezeanu, Alexandra Bargan, Mihaela Homocianu, Magdalena Aflori, Cristina Mihaela Rîmbu, Alexandru Alin Enache and Tăchiță Vlad-Bubulac (Romania, Nanomaterials). In this paper, hydroalcoholic solutions of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba were used in combination with poly (vinyl alcohol) with the aim of developing novel poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents via the electrospinning technique.


Defense or repair: How immune cells are controlled during wound healing - Sciencedaily.com
A Cologne-based research team has discovered that the metabolism of mitochondria, the energy suppliers of cells, in macrophages coordinate wound healing to a significant degree. Macrophages belong to the white blood cells and are also known as scavenger cells.


The Role of Negative Pressure Wound Therapy (NPWT) in the Management of Vasculitic Wounds: Case Series of Eight Patients - PubMed
Abstract by Kirsi Isoherranen, Nicolas Kluger, Katariina Hannula-Jouppi and Liisa Väkevä (Helsinki, Finland - Int J Low Extrem Wounds).


The Effects of Curcumin Nanoparticles Incorporated into Collagen-Alginate Scaffold on Wound Healing of Skin Tissue in Trauma Patients - Mdpi.com
Article by Mohammadmahdi Mobaraki, Davood Bizari, Madjid Soltani, Hadi Khshmohabat, Kaamran Raahemifar and Mehdi Akbarzade Amirdehi (Iran, Canada, USA - Polymers). The authors' results revealed the potential of nanocurcumin incorporated in COL/ALG scaffolds for the wound healing of skin tissue in trauma patients.


Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate - Hindawi.com
Article by Bingqing Li, Kun Xu and Xin Liu (Qingdao, China - Journal of Healthcare Engineering). On the basis of targeted nursing intervention, applying silver-zinc bacteriostatic cream obtains an obviously better clinical efficacy than silver sulfadiazine ointment in treating second-degree burn and works better in promoting wound healing, relieving pain sensation, and reducing adverse reactions.


Novel therapeutic targets for diabetes-related wounds: An update on pre-clinical and clinical research - Tandfonline.com
Abstract by Jonathan Golledge and Shivshankar Thanigaimani (Townsville, Australia - Expert Opinion on Therapeutic Targets).


A novel protein therapy for efficient skin wound healing - Eurekalert.org
Singapore scientists have discovered a protein that could be used in wound dressings to heal chronic wounds. These findings could pave the way for the development of Agrin protein therapy to accelerate skin tissue healing for chronic wounds from diabetes or burns.


Multifunctional Single-Component Polypeptide Hydrogels: The Gelation Mechanism, Superior Biocompatibility, High Performance Hemostasis, and Scarless Wound Healing - PubMed
Abstract by Qian Bai, Lin Teng, Xueliang Zhang and Chang-Ming Dong (Shanghai, China - Adv Healthc Mater.).


A Pragmatic, Single-Center, Prospective, Randomized Controlled Trial of Adjunct Hemoglobin-Mediated Granulox Topical Oxygen Therapy Twice Weekly for Foot Ulcers - PubMed
Abstract by Leon Jonker, Danielle Smith, Emma Mark, Sarah Thornthwaite, Carol Gunn and Stacey Fisher (J Am Podiatr Med Assoc.).


Can Intralesional Epidermal Growth Factor Reduce Skin Graft Applications in Patients with Diabetic Foot Ulcer? - PubMed
Abstract by Bayram Colak, Serdar Yormaz, Ilhan Ece and Mustafa Sahin (J Am Podiatr Med Assoc.).


Wound Healing and Therapy in Soft Tissue Defects of the Hand and Foot from a Surgical Point of View - Mdpi.com
Article by Wolfram Demmer, Heiko Sorg, Andreas Steiert, Jörg Hauser and Daniel Johannes Tilkorn (Germany, Medical Sciences). An overview of different treatment and dressing techniques is given with special emphasis on the reconstruction of damaged structures by plastic surgical means.


Nano-Silver Medical Antibacterial Dressing Combined with High-Flow Oxygen Therapy Facilitates Ulcer Wound Healing of Superficial Malignant Tumors - Dovepress.com
Article by Dan Yu, Di-Xiao Yang, Yao Li, Bi Guan, Qian Ming, Yan Li, Yi-Ping Zhu, Li-Qing Chen and Wei-Xiang Luo (China - Cancer Management and Research). Nano-silver medical antibacterial dressing combined with high-flow oxygen therapy can reduce the frequency of dressing changes in patients, relieve pain, reduce inflammation, and accelerate the healing of superficial malignant tumor ulcer wounds.


Researchers devise a novel approach to print skin equivalents - Themedicalprogress.com
Researchers from the University of Birmingham and University of Huddersfield created a method to print skin-like substitutes. The material could be used to aid in healing of chronic wounds. This technique simulates three layers of skin, the hypodermis (or the fatty layer) the dermis, and the epidermis.


Burns, Superficial Partial-Thickness (Second-Degree) - Woundsource.com
A burn is an injury to the tissue of the body, typically the skin. Burns can vary in severity from mild to life-threatening. Most burns only affect the uppermost layers of skin, but depending on the depth of the burn, underlying tissues can also be affected.


Evaluation of In Vitro Wound-Healing Potential, Antioxidant Capacity, and Antimicrobial Activity of Stellaria media (L.) Vill - Mdpi.com
Article by Florina Miere (Groza), Alin Cristian Teușdea, Vasile Laslo, Simona Cavalu, Luminița Fritea, Luciana Dobjanschi, Mihaela Zdrânca, Marcel Zdrânca, Mariana Ganea, Priscilla Pașc, Adriana Ramona Memete, Angela Antonescu, Andreea Margareta Vlad and Simona Ioana Vicas (Oradea, Romania - Applied Sciences). This study showed that Stellaria media is a source of polyphenols compounds with antioxidant capacity, and for the first time, its wound healing potential was emphasized.


MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy - Biomedcentral.com
Article by Faroogh Marofi, Kozlitina Iuliia Alexandrovna, Ria Margiana, Mahta Bahramali, Wanich Suksatan, Walid Kamal Abdelbasset, Supat Chupradit, Maryam Nasimi and Marwah Suliman Maashi (Iran, Indonesia, Thailand, Saudi Arabia, Egypt - Stem Cell Research & Therapy). In this review, the authors focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.


A Comparison of the Biomechanical Performance of 3 Negative Pressure Wound Therapy Foams - PubMed
Abstract by Daniel J Gibson (Tuscaloosa, USA - J Wound Ostomy Continence Nurs.).


Negative pressure wound therapy compared with conventional wound dressings for closed incisions in orthopaedic trauma surgery: A meta-analysis - PubMed
Abstract by Weiwei Xie, Lingyan Dai, Yameng Qi and Xixi Jiang (China - Int Wound J.).


Roles of Oxidative Stress and Raftlin in Wound Healing Under Negative-Pressure Wound Therapy - PMC
Article by Xingan Qiu, Yifan Wu, Dong Zhang, Hao Zhang, Aixi Yu and Zonghuan Li (Wuhan, China - Clin Cosmet Investig Dermatol. ). NPWT may promote wound healing by upregulating Raftlin and inhibiting oxidative stress levels.


Clinical Utility of Silk-Elastin Sponge in Patients with Chronic and Acute Skin Ulcers: Study Protocol of a Multicenter Clinical Trial - Springer.com
Article by Kazuo Noda, Yasuhiro Katayama, Eiichi Sawaragi, Michiharu Sakamoto, Hiroki Yamanaka, Itaru Tsuge, Motoki Katsube and Naoki Morimoto (Japan - Dermatol Ther (Heidelb)). The central aim of this trial is to evaluate the clinical utility and safety of silk-elastin sponge for the treatment of chronic and acute skin ulcers.


Nutrition and cutaneous wound healing - PubMed
Abstract by Ayman Grada and Tania J Phillips (Boston, USA - Clin Dermatol.).


Two Cases of Impaired Wound Healing Among Patients With Major Head and Neck Free-Flap Reconstruction in the Setting of COVID-19 Infection - Cureus.com
Article by Daniel Inouye, Sheng Zhou, Bhavishya Clark, Mark Swanson and Tamara Chambers. SARS-CoV-2 infection during the immediate postoperative period of head and neck reconstruction procedures may elevate the risk of major wound complications. Special consideration must be taken when performing free tissue transfers during the COVID-19 pandemic.


Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion - Mdpi.com
Article by Tamer M. Tamer, Mosa H. Alsehli, Ahmed M. Omer,Tarek H. Afifi, Maysa M. Sabet, Mohamed S. Mohy-Eldin and Mohamed A. Hassan (Egypt, Saudi Arabia, Germany - IJMS). The authors' findings suggest the prospective usage of the PVA-M0.5-K0.1 sponge in wound healing for hemorrhage and bacterial infection control.


Wound photography for evaluation of surgical site infection and wound healing after lower limb trauma - PubMed
Abstract by Julie Bruce, Ruth Knight, Nick Parsons, Ria Betteridge, Amy Verdon, Julie Brown, Marta Campolier, Juul Achten and Matt L Costa (UK - Bone Joint J.).


Effect of topical application of platelet-rich plasma on chronic venous leg ulcerations - PubMed
Abstract by Simon Bossart, S Morteza Seyed Jafari, Mathias Lehmann, Andreas Jossi-Will, Esther Sane, Kristine Heidemeyer, Petra Schorno, Lorenzo Pelloni, Anna Rammlmair and Christoph Schlapbach (Bern, Switzerland - Dermatol Ther.).


Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing - Oup.com
Article by Xiaoxuan Lei, Liuhanghang Cheng, Yu Yang, Mengru Pang, Yunqing Dong, Xuanru Zhu, Caihong Chen, Zexin Yao, Gang Wu, Biao Cheng and Tymour Forouzanfar (China, The Netherlands - Burns & Trauma). Co-administration of small intestinal submucosa and platelet-rich plasma has a better effect on promoting angiogenesis, re-epithelialization and collagen regeneration in managing acute wound healing than either agent alone.


Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro - Nature.com
Article by Mickey V. Patel, Marta Rodriguez-Garcia, Zheng Shen and Charles R. Wira (USA - Scientific Reports). The authors' findings highlight the importance of evaluating progestins for their impact on wound repair at mucosal surfaces.


Study on the Effect and Mechanism of Antibacterial Adhesive Hydrogel on Wound Healing - Hindawi.com
Article by Xiaodong Wang, Xuehong Pan, Nana Zhao and Defang Chen (China - Computational and Mathematical Methods in Medicine). It is proven that the antibacterial adhesive hydrogel dressing has a significant effect on wound healing.


3D printing of blood plasma may speed up wound healing - Medicalxpress.com
New research by RCSI University of Medicine and Health Sciences suggests that effective wound healing may be aided by replicating a crucial component of our blood.


Wound Healing Activities and Potential of Selected African Medicinal Plants and Their Synthesized Biogenic Nanoparticles - Mdpi.com
Article by Caroline Tyavambiza, Phumuzile Dube, Mediline Goboza, Samantha Meyer, Abram Madimabe Madiehe and Mervin Meyer (Cape Town, South Africa - Plants). The continued scientific evaluation of wound healing African medicinal plants and the development of novel nanomaterials using these plants is imperative in a bid to alleviate the detrimental effects of chronic wounds.


Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A - Mdpi.com
Article by Cornelia Wiegand, Uta-Christina Hipler, Peter Elsner and Jörg Tittelbach (Jena, Germany - Biomedicines). Keratinocyte and fibroblast wound healing under non-optimal conditions was found to be distinctly reduced in vitro. wIRA treatment could counteract the inflammatory response in infected keratinocytes as well as under chronic inflammatory conditions by decreasing pro-inflammatory cytokine gene expression and improve wound healing.


Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair - Frontiersin.org
Article by Holly N. Wilkinson, Barbara-Ann Guinn and Matthew J. Hardman (Hull, UK - Frontiers in Cell and Developmental Biology). The authors' data highlight potential new and diverse roles for metals in cutaneous wound repair, paving the way for further studies to elucidate the contribution of metals to cellular processes in the repair of skin and other tissues.