Lymphedema / Phlebolymphedema - Woundsource.com
Lymphedema (alternate spelling: lymphoedema) is a condition marked by the retention of interstitial fluid (lymph) and the swelling (edema) of surrounding soft tissue, often affecting the extremities. It is also referred to as lymphatic obstruction.
Pediatric Patients - Woundsource.com
There is often an association when caring for pediatric wounds that they can heal rapidly and that patients have remarkable resilience. This perpetuating thought has resulted in a lack of focus on wound care knowledge in pediatrics.1 In reality, these patients are among the most vulnerable populations, generally have skin that is more fragile than adult skin, and many of their systems are immature, which can complicate wound care.
Critical Components to Encourage Wound Healing: Basing Treatment on Etiology - Woundsource.com
Article by Holly Hovan. Wound care and healing require an evidenced-based, interprofessional approach, following standards of care, and treating the whole patient, not just the hole in the patient. Often, wound care clinicians are consulted for recommendations on the treatment of chronic or non-healing wounds, as well as other wound, ostomy, and continence issues. Treating a wound and successfully healing a wound require a holistic approach for the best outcomes.
Hypofractionated radiation therapy and wound healing after massive sarcoma resection: Case report and review of the literature - PubMed
Abstract by Michael Allen, Daniella Silvino, Mitchell Kamrava, Wonwoo Shon and Earl Brien (USA - Int J Surg Case Rep.).
Study: Topical Cannabinoids Heal Intractable Leg Ulcers - Norml.org
The topical administration of plant-derived cannabinoids is associated with wound closure in patients with refractory leg ulcers, according to data published in the journal Experimental Dermatology.
Development of nitric oxide releasing visible light crosslinked gelatin methacrylate hydrogel for rapid closure of diabetic wounds - PubMed
Abstract by Alap Ali Zahid, Robin Augustine, Yogesh B Dalvi, K Reshma, Rashid Ahmed, Syed Raza Ur Rehman, Hany E Marei, Rashad Alfkey and Anwarul Hasan (Quatar, India, Egypt - Biomed Pharmacother.).
An antibacterial bilayer hydrogel modified by tannic acid with oxidation resistance and adhesiveness to accelerate wound repair - PubMed
Abstract by Yang Li, Rongzhan Fu, Chenhui Zhu and Daidi Fan (Shaanxi, China - Colloids Surf B Biointerfaces)
Investigation into antibacterial and wound healing properties of platelets lysate against Acinetobacter baumannii and Klebsiella pneumoniae burn wound infections - Biomedcentral.com
Article by Aref Shariati, Alireza Moradabadi, Ehsanollah Ghaznavi-Rad, Maryam Dadmanesh, Majid Komijani and Farshad Nojoomi (Iran - Annals of Clinical Microbiology and Antimicrobials).
The use of topical PdB is an attractive strategy for treating A. baumannii and K. pneumoniae burn wound infections because it inhibits bacterial growth and promotes wound healing properties.
Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment - Nature.com
Article by Aaron Martínez-Higuera, César Rodríguez-Beas, Jesús Mauro Adolfo Villalobos-Noriega, Abraham Arizmendi-Grijalva, Carlos Ochoa-Sánchez, Eduardo Larios-Rodríguez, Juan Manuel Martínez-Soto, Ericka Rodríguez-León, Cristina Ibarra-Zazueta, Roberto Mora-Monroy, Hugo Alejandro Borbón-Nuñez, Alfonso García-Galaz, María del Carmen Candia-Plata, Luis Fernando López-Soto and Ramón Iñiguez-Palomares (Mexico - Scientific Reports).
Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.
Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF) - An In Vitro Wound Healing Study - Mdpi.com
Article by Magdalena Jedrzejczak-Silicka, Marian Kordas, Maciej Konopacki and Rafał Rakoczy (Szczecin, Poland - Molecular Sciences).
It can be stated that the subtle balance in the ROS level is crucial in the wound for the effective healing process, and it is possible to modulate the cellular response to the RMF in the context of an in vitro wound healing.
Recent trends on burn wound care: hydrogel dressings and scaffolds - Rsc.org
Abstract by Yingxia Yao, Andi Zhang, Congshan Yuan, Xiguang Chen and Ya Liu (Qingdao, China - Biomaterials Science).
Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care - Mdpi.com
Article by Andreea-Mariana Matei, Constantin Caruntu, Mircea Tampa, Simona Roxana Georgescu, Clara Matei, Maria Magdalena Constantin, Traian Vasile Constantin, Daniela Calina, Diana Alina Ciubotaru, Ioana Anca Badarau, Cristian Scheau and Ana Caruntu (Romania - Applied Sciences).
Different types of nanosized-lipid-based drug delivery systems, such as vesicular systems and lipid nanoparticles, demonstrated better applicability and enhanced skin penetration in wound healing therapy compared with conventional treatments.
Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing - Sciencemag.org
Article by Chen Hu,Chenyu Chu, Li Liu, Chenbing Wang, Shue Jin, Renli Yang, Shengan Rung, Jidong Li, Yili Qu and Yi Man (China - Science Advances).
In mice without mature T lymphocytes, lack of wound-induced hair neogenesis indicated a regulatory role of T cells on hair follicle regeneration. The microenvironment around scaffolds involved an intricate interplay of immune and cutaneous cells.
Metabolic Profiling of VOCs Emitted by Bacteria Isolated from Pressure Ulcers and Treated with Different Concentrations of Bio-AgNPs - PubMed
Abstract by Fernanda Monedeiro, Viorica Railean-Plugaru, Maciej Monedeiro-Milanowski, Paweł Pomastowski and Bogusław Buszewski (Toruń, Poland - Int J Mol Sci.).
COVID-19 patients in prone position: validation of instructional materials for pressure injury prevention - PubMed
Abstract by Vinicius Batista Santos, Daniele Cristina Bosco Aprile, Camila Takáo Lopes, Juliana de Lima Lopes, Mônica Antar Gamba, Karina Aparecida Lopes da Costa and Tânia Arena Moreira Domingues (São Paulo, Brazil - Rev Bras Enferm.).
Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing - PubMed
Abstract by Mei-Hua Jin, Nan-Nan Yu, Ying-Hua Jin, Ying-Ying Mao, Lin Feng, Yue Liu, Ai-Guo Wang, Hu-Nan Sun, Taeho Kwon and Ying-Hao Han (China, Korea - Aging (Albany NY)).
Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing - Mdpi.com
Article by Beata Kaczmarek-Szczepańska, Justyna Ostrowska, Justyna Kozłowska, Zofia Szota, Anna A. Brożyna, Rita Dreier, Russel J. Reiter, Andrzej T. Slominski, Kerstin Steinbrink and Konrad Kleszczyński (Poland, Germany, USA - IJMS).
The authors' results demonstrate that the indoleamine accelerates re-epithelialization. This delivery is a promising technique for additional explorations in future dermatotherapy and protective skin medicine.
Evaluation of Ehretia Laevis Roxb. (Khandu Chakka/Ajan Vruksha) in the Wound Healing Adjudged by Histological Examination of the Tissue - Medicopublication.com
Article by Rushikesh Thakre, Arvinda Bhake, Pradip Tekade, Ketaki Harne and Preeti Sujit Borkar (Wardha, India - Indian Journal of Forensic Medicine & Toxicology).
Ehretia Laevis Roxb. is concluded to promote the healing significantly as observed by feature of granulation, collagenisation & re-epithelisation of the wounds suggesting early healing by primary intension.
Backrest elevation in the semi-lateral position: Case of a sacral pressure ulcer with undermining formation - PubMed
Abstract by Yoshiko Takahashi, Fumihiro Mizokami, Makiko Tanaka, Tetsuya Nemoto and Zenzo Isogai (Japan - J Tissue Viability).
Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing - Sciencedirect.com
Abstract by Islam M. Adel, Mohamed F. ElMeligy, Abdel Fattah A. Abdelkhalek and Nermeen A. Elkasabgy (Cairo, Egypt - European Journal of Pharmaceutical Sciences).
Investigating auranofin for the treatment of infected diabetic pressure ulcers in mice and dermal toxicity in pigs - Nature.com
Article by Haroon Mohammad, Nader S. Abutaleb, Alexandra M. Dieterly, L. Tiffany Lyle and Mohamed N. Seleem (USA).
Auranofin appears to be a potent and safe topical agent to further investigate for treatment of mild-to-moderate MRSA-infected diabetic PUs.
Malnutrition delayed wound healing after tooth extraction by HMGB1-related prolonged inflammation - Sciencedirect.com
Article by Yao Zhang, Hidetaka Ideguchi, Hiroaki Aoyagi, Keisuke Yamashiro, Tadashi Yamamoto, Masahiro Nishibori and Shogo Takashiba (Japan - International Immunopharmacology).
The authors' results suggest that the significantly increased secretion of HMGB1 associated with the upregulated production of ATP and IL-1β secretion via the RAGE pathway may interfere with the resolution of inflammation and wound healing under the state of malnutrition.
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Pearl Powder - An Emerging Material for Biomedical Applications: A Review - Mdpi.com
Article by Xian Jun Loh, David James Young, Hongchen Guo, Liang Tang, Yun-Long Wu, Guorui Zhang, Changming Tang and Huajun Ruan (Singapore, Australia, China - Materials).
In this review, the authors focus on the emerging biomedical applications of pearl powder, touching on applications of pearl powder in wound healing, bone repairing, treatment of skin conditions, and other health indications.
The role of Helianthus tuberosus powder in healing of full-thickness wounds in mice - Veterinaryworld.org
Article by Ali Ghazi Atiya and Nadia Hameed Rija AL-Falahi (Iraq - Veterinary World).
H. tuberosus powder acts as an antibacterial agent with the ability to enhance the wound healing process.
Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process - Mdpi.com
Article by Ipek Süntar, Sümeyra Çetinkaya, Emiliano Panieri, Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo and Luciano Saso (Turkey, Italy - Molecules).
This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
Survival upon Staphylococcus aureus mediated wound infection in Caenorhabditis elegans and the mechanism entailed - PubMed
Abstract by Murugesan Pooranachithra, Suruthi Kanagavel, Bhaskar J Prabhanand, Murali Deepa, Das Shibendu Sekhar, Krishnan Venkateswaran, Gajbhiye Rahul, Velayutham Ravichandiran and Krishnaswamy Balamurugan (India - Microb Pathog.).
The promising pro-healing role of the association of mesoglycan and lactoferrin on skin lesions - PubMed
Abstract by Raffaella Belvedere, Emanuela Pessolano, Nunzia Novizio, Alessandra Tosco, Daniela Eletto, Amalia Porta, Amelia Filippelli, Francesco Petrella and Antonello Petrella (Italy - Eur J Pharm Sci.).
The preventive effect of seamless nursing care on pressure ulcer and related complications in elderly inpatients - PubMed
Abstract by Feina Xiao, Huiping Peng and Yusi Li (Zhuhai, China - Am J Transl Res.).
Novel chitosan-ulvan hydrogel reinforcement by cellulose nanocrystals with epidermal growth factor for enhanced wound healing: In vitro and in vivo analysis - Sciencemag.com
Abstract by Kazharskaia Mariia, Muhammad Arif, Jie Shi, Fulai Song, Zhe Chia and Chenguang Liua (China - International Journal of Biological Macromolecules).
Early wound repair versus later scar repair in children with treadmill hand friction burns - PubMed
Abstract by Rong Zhou, Lin Qiu, Jun Xiao, Xiaobo Mao and Xingang Yuan (Chongqing, China - J Burn Care Res.).
Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction - Mdpi.com
Article by Shun Kimura and Takashi Tsuji (Japan, IJSM).
In this review, the authors present an overview of recent studies of biomechanical and immunological wound healing and tissue remodelling mechanisms through comparisons of species- and developmental stage-dependent wound healing mechanisms. They also discuss the possibility of elucidating the control mechanism of wound healing involving mechanobiological and immunological interaction by using next-generation human skin equivalents.
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring - Sciencemag.org
Article by Yuji Gao, Dat T. Nguyen, Trifanny Yeo, Su Bin Lim, Wei Xian Tan, Leigh Edward Madden, Ji Yong Kenan Long, Fazila Abu Bakar Aloweni, Yi Jia Angela Liew, Mandy Li Ling Tan, Shin Yuh Ang, Sivagame D/O Maniya, Ibrahim Abdelwahab, Kian Ping Loh, Chia-Hung Chen, David Laurence Becker, David Leavesley, John S. Ho and Chwee Teck Lim (Singapore, China - Science Advances).
The authors demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
Interleukin-1β-induced matrix metalloproteinase-3 via ERK1/2 pathway to promote mesenchymal stem cell migration - Plos.org
Article by Chun-Hao Chang, Yun-Li Lin, Yeu-Sheng Tyan, Yun-Hsuan Chiu, Ya-Han Liang, Chie-Pein Chen, Jiahn-Chun Wu and Hwai-Shi Wang.
The authors have found that IL-1β induces the expression of MMP-3 through ERK1/2, JNK, p38 MAPK and Akt signaling pathways to enhance the migration of hUCMSCs. These results provide further understanding of the mechanisms in IL-1β-induced hUCMSCs migration to injury sites.
Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis - Biomedcentral.com
Article by Xiaoting Liang, Fang Lin, Yue Ding, Yuelin Zhang, Mimi Li, Xiaohui Zhou, Qingshu Meng, Xiaoxue Ma, Lu Wei, Huimin Fan and Zhongmin Liu (China - Stem Cell Research & Therapy).
The authors' findings indicate that iMSC-CdM is more effective than uMSC-CdM in treating cutaneous wounds, and in this way, iMSC-CdM may serve as a more constant and sustainable source for cell-free therapeutic approach.
What’s the Connection Between Diabetes and Wound Healing? - Healthline.com
Diabetes is a result of your body’s inability to produce or use insulin. Insulin is a hormone that allows your body to turn glucose, or sugar, into energy. If your body has difficulty metabolizing glucose, it can lead to high blood sugar levels. This can affect your body’s ability to heal wounds.
Treatment of a Complex Pressure Ulcer Using a Synthetic Hybrid-Scale Fiber Matrix - PubMed
Abstract by Karena Herron (Auburn, USA - Cureus).
Impact of Previous Irradiation on Wound Healing after Negative Pressure Wound Therapy in Head and Neck Cancer Patients - A Systematic Review - Mdpi.com
Article by Muhammad Faisal, Peter D. Berend, Rudolf Seemann, Stefan Janik, Stefan Grasl, Andrea Ritzengruber, Herbert Mendel, Arif Jamshed, Raza Hussain and Boban M. Erovic (Austria, Pakistan - Cancers).
The study has focused on the use of Negative Pressure Wound Therapy (NPWT) specifically in head and neck cancer patients. The sole purpose of using NPWT is to expedite the process of healing as most of the head and neck cancer patients are bound to get post-operative radiotherapy and any delay would further lengthen the treatment and affect the outcome. Previous irradiation and Diabetes Mellitus have detrimental impact on wound healing after NPWT.
Myofibroblast Progeny in Wound Biology and Wound Healing Studies - PubMed
Abstract by P Monika, P Veena Waiker, M N Chandraprabha, Annapoorni Rangarajan and K N Chidambara Murthy (Bangalore, India - Wound Repair Regen.).
Reactive air surfaces for preventing pressure ulcers - PubMed
Abstract by Chunhu Shi, Jo C Dumville, Nicky Cullum, Sarah Rhodes, Vannessa Leung and Elizabeth McInnes (UK, Australia - Cochrane Database Syst Rev.).
The effects of whole-body vibration on wound healing in a mouse pressure ulcer model - PubMed
Abstract by Nattaya Wano, Sompol Sanguanrungsirikul, Somboon Keelawat and Juraiporn Somboonwong (Bangkok, Thailand - Heliyon).
Wound Healing and Antioxidant Evaluations of Alginate from Sargassum ilicifolium and Mangosteen Rind Combination Extracts on Diabetic Mice Model - Mdpi.com
Article by Pugar Arga Cristina Wulandari, Zulfa Nailul Ilmi, Saikhu Akhmad Husen, Dwi Winarni, Mochammad Amin Alamsjah, Khalijah Awang, Marco Vastano, Alessandro Pellis, Duncan MacQuarrie and Pratiwi Pudjiastuti (Indonesia, Malaysia, UK, Austria - Applied Sciences).
The treatment of the DA and DAM groups showed a decrease in wound width and an increase in the number of fibrocytes, fibroblasts, and macrophages. The number of neutrophils decreased while the percentage of collagen densities increased for all the considered groups.
Early Interventions for Limb Salvage - Woundsource.com
Approximately 2 million people in the United States are living with limb loss, and this figure is expected to double by 2050. Lower-limb amputation accounts for the vast majority of all amputations, and diabetes - specifically, diabetic foot ulcers (DFUs) - is the leading cause of nontraumatic lower-limb amputations in the US. Although already high, the rate of amputation is increasing.
Functional Imaging in Wounds: Imaging Modalities of Today and Tomorrow - PubMed
Abstract by Scott Stratman, Caralin Schneider, Hadar Lev-Tov and Robert S Kirsner (Miami, USA - Surg Technol Int.).
A Novel Biofilm-Disrupting Wound Care Technology for the Prevention of Surgical Site Infections Following Total Joint Arthroplasty: A Conceptual Review - PubMed
Abstract by Hytham S Salem and Michael A Mont (New York, USA - Surg Technol Int.).
Enhancing wound healing dressing development through interdisciplinary collaboration - PubMed
Abstract by Briauna Hawthorne, J Kai Simmons, Braden Stuart, Robert Tung, David S Zamierowski and Adam J Mellott (Kansas City, USA - J Biomed Mater Res B Appl Biomater.).
Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review - Mdpi.com
Article by Matúš Čoma, Veronika Lachová, Petra Mitrengová and Peter Gál (Slovakia, Czech Republic - CIMB).
Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, the authors present here a wound healing phases-based review of the most studied naturally occurring SERM.
In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential - Frontiersin.org
Article by Ekta Yadav, Pankajkumar Yadav and Amita Verma (Prayagraj, India - Front. Pharmacol.).
Rats treated with FeTP showed significantly swift healing with faster wound contraction rate, high tensile strength and hydroxyproline content along with the utilization of less time for epithelialization. Histopathological study also validated the potential wound healing effect of FeTP with complete re-epithelialization.
The use of human acellular dermal matrices in advanced wound healing and surgical procedures: state of the art - PubMed
Abstract by Linda Tognetti, Elisa Pianigiani, Francesca Ierardi, Guido Lorenzini, Donato Casella, Flavio Giulio Liso, Andrea De Pascalis, Elisa Cinotti and Pietro Rubegni (Siena, Italy - Dermatol Ther.).
Combined internal and external negative pressure wound therapy: breakthrough treatment for lymphocutaneous intractable fistula - PubMed
Abstract by Takahiro Miura, Yuhei Yamamoto, Naoki Murao, Taku Maeda, Masayuki Osawa, Toshihiko Hayashi and Emi Funayama (Sapporo, Japan - Surg. Today).
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Classification and Production of Polymeric Foams among the Systems for Wound Treatment - Rsc.org
Article by Paolo Trucillo and Ernesto Di Maio (Italy - Polymers).
This work represents an overview on types of wounds according to their definition, classification and dressing treatments. Natural and synthetic polymeric wound dressings types have been analyzed, providing a historical overview, from ancient to modern times.
Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels - Sciencedirect.com
Article by Xiaofan Feng, Xiuling Hou, Congjing Cui, Shibin Sun, Sahiya Sadik, Shaohua Wu and Fang Zhou (Shandong, China - Engineered Regeneration).
The objective of this study was to develop an effective, potential wound dressing, which was constructed with a composite hydrogel of poly(vinyl alcohol) (PVA), carboxymethyl chitosan (CMC) and tannic acid (TA) by cryogenic treatment and freeze-drying method.
Pharmacological Screening for Burn Wound Healing Potential of Traditional Plant Cassia fistuliain in Rats - Jdvat.org
Article by Hajera Khanam and Nishat Fatima (Telangana, India - Journal of Drug Vigilance and Alternative Therapies).
The hydroxyproline level was found to be substantially elevated in aqueous and ethanolic extracts of Cassia fistula leaves treated groups. The efficacy of Cassia fistulaleaves in improving wound healing was also discovered by histopathological analysis of the cream-treated rat wound tissues.
Serum exosomes accelerate diabetic wound healing by promoting angiogenesis and ECM formation - PubMed
Abstract by Liushan Chen, Linghao Qin, Chujun Chen, Qiong Hu, Junjian Wang and Juan Shen (Guangzhou, China - Cell Biol Int.).
Cell-free exosome-laden scaffolds for tissue repair - Rsc.org
Article by Jianghong Huang, Jianyi Xiong, Lei Yang, Jun Zhang, Shuqing Sun and Yujie Liang (Shenzhen, China - Nanoscale).
This review introduces exosomes from the aspects of biogenesis, composition, identification, and isolation, and focuses on the development status of scaffold materials for exosome delivery.
3D-printed hydrogels with improved tunable properties - Labnews.co.uk
The design of 3D-printable seaweed hydrogels that use multiple interpenetrating networks to enable enhanced mechanical properties offer new applications in biomedical materials, 3D printing, and soft robotics. New research reports a class of self-reinforced homocomposite hydrogels (HHGs) offering more tunable properties for jelly materials that can be used for improved wound healing and drug delivery products.
Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models - Mdpi.com
Article by Calin Vasile Andritoiu, Corina Elena Andriescu, Maricel Danu, Cristina Lungu, Bianca Ivanescu, Cornel Havarneanu and Marcel Popa (Romania - Pharmaceuticals).
The aim of this paper was the preparation and investigation of the wound healing properties of four topical formulations based on natural polymers such as collagen, chitosan, lyophilized egg white, and a mixture of them.
Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels - Sciencedirect.com
Abstract by Syed Ahmed Shah, Muhammad Sohail, Shujaat Ali Khan and Mubeen Kousar (Islamabad, Pakistan - Materials Science and Engineering: C).
Single-use negative pressure wound therapy reduces costs in closed surgical incisions: UK and US economic evaluation - PubMed
Abstract by Leo M Nherera, Chris Saunders, Sanjay Verma, Paul Trueman and Francis Fatoye (USA, UK - J Wound Care).
A novel debridement device for the treatment of hard-to-heal wounds: a prospective trial - PubMed
Abstract by Omar Al-Jalodi, Laura M Serena, Kristy Breisinger, Keyur Patel, Khristina Harrell and Thomas E Serena (Cambridge, USA - J Wound Care).
Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity - Sciencedirect.com
Article by Sophia Hauck, Paula Zager, Norbert Halfter, Elke Wandel, MartaTorregrossa, Ainur Kakpenova, Sandra Rother, Michelle Ordieres, Susann Räthel, Albrecht Berg, Stephanie Möller, Matthias Schnabelrauch, Jan C. Simon, Vera Hintze and Sandra Franz (Germany - Bioactive Materials).
The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation, augmented pro-regenerative macrophage activation, increased vascularization, and accelerated new tissue formation and wound closure.
Nanoclay/Polymer-Based Hydrogels and Enzyme-Loaded Nanostructures for Wound Healing Application - Mdpi.com
Article by Angel M. Villalba-Rodríguez, Sara Martínez-González, Juan Eduardo Sosa-Hernández, Roberto Parra-Saldívar, Muhammad Bilal and Hafiz M. N. Iqbal (Mexico, China - Gels).
The setup explored in this research allows for a promising polymeric matrix that can potentially be loaded with active compounds for antibacterial support in foot ulcers, as well as enzymes for wound debridement.
Anti-inflammation biomaterial platforms for chronic wound healing - Rsc.org
Abstract by Zejun Xu, Biao Liang, Junzhang Tian and Jun Wu (Biomaterials Science).
Injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting wound healing process through photobiomodulation - Rsc.org
Abstract by Mengsi Ma, Yalan Zhong and Xulin Jiang (Journal of Materials Chemistry B).
A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model - Mdpi.com
Article by Maria Teresa Colangelo, Silvana Belletti, Paolo Govoni, Stefano Guizzardi and Carlo Galli (Parma, Italy - Applied Sciences).
The authors results demonstrate that PN + HA is a promising candidate for a supportive therapy to promote soft tissue healing in the oral cavity.
Biopolymers for wound therapy deliver stem cells to improve healing - Phys.org
NUS researchers have discovered a method to fabricate a biologic interpenetrating network (IPN) hydrogel using applied rheology.
Enzymatic Debridement: How Does it Work? - Woundsource.com
Complex and hard-to-heal chronic wounds impact millions of people globally. In the United States, care for these types of wounds exceeds $25 billion annually. Wound healing naturally progresses through the overlapping phases of hemostasis, inflammation, proliferation, and remodeling. With chronic and complex wounds, the natural biological healing process stalls in the inflammatory phase, thereby preventing both the proliferative phase and further advancement toward wound closure.
A clinical comparison of pure knitted silk and a complex synthetic skin substitute for the treatment of partial thickness burns - PubMed
Abstract by Jennifer Lynn Schiefer, Janine Andreae, Mahsa Bagheri, Paul Christian Fuchs, Rolf Lefering, Wolfram Heitzmann and Alexandra Schulz (Cologne, Germany - Int Wound J.).
Periodontal Wound Healing and Tissue Regeneration: A Narrative Review - Mdpi.com
Article by Young-Dan Cho, Kyoung-Hwa Kim, Yong-Moo Lee, Young Ku and Yang-Jo Seol (Seoul, Korea - Pharmaceuticals).
The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes.
Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities - Sciencedirect.com
Article by Dereje Nigussie, Eyasu Makonnen, Takele Beyene Tufa, Malcolm Brewster, Belete Adefris Legesse, Abebaw Fekadu and Gail Davey (Ethiopia, UK - Journal of Ethnopharmacology).
Lawsonia inermis, Azadirachta indica, Achyranthes aspera, and Cuminum cyminum are the most studied plant species in terms of anti-inflammatory activity, while Lawsonia inermis and Azadirachta indica are the most studied ones for wound healing.
Nicotinamide Riboside Enhances Endothelial Precursor Cell Function to Promote Refractory Wound Healing Through Mediating the Sirt1/AMPK Pathway - Frontiersin.org
Article by Zhen-hua Wang, Xiao-gang Bao, Jun-jie Hu, Si-bo Shen, Guo-hua Xu and Ye-lin Wu (China).
This study demonstrates that the oral uptake of nicotinamide riboside enhances the EPC function to promote diabetic wound healing, indicating that NR supplementation might be a promising strategy to prevent the progression of diabetic complications.
Ultrasound enhanced synthetic platelet therapy for augmented wound repair - PMC
Article by Seema Nandi, Kaustav Mohanty, Kimberly Nellenbach, Mary Erb, Marie Muller and Ashley C. Brown (Raleigh, USA - ACS Biomater Sci Eng.).
The authors found that application of ultrasound in combination with a subtherapeutic dosage of PLPs resulted in increased clot density and stiffness, improved fibroblast migration in vitro and increased epidermal thickness and angiogenesis in vivo, indicating that this combination therapy has potential to facilitate multiphase pro-healing outcomes.
Collagen in Wound Healing - Mdpi.com
Article by Shomita S. Mathew-Steiner, Sashwati Roy and Chandan K. Sen (Indianapolis, USA - Bioengineering).
In this work the significance of collagen in different biological processes relevant to wound healing are reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided.
Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing - Biomedcentral.com
Article by Christian Ploner, Tina Rauchenwald, Catherine E. Connolly, Karin Joehrer, Johannes Rainer, Christof Seifarth, Martin Hermann, Markus Nagl, Susanne Lobenwein, Doris Wilflingseder, Giuseppe Cappellano, Evi M. Morandi and Gerhard Pierer (Austria, Italy - Stem Cell Research & Therapy).
The appearance of adipocytes in wound tissue indicates a prevailing anti-inflammatory environment that could be promoted by NCT treatment and may be associated with improved healing outcomes.
A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis - PubMed
Abstract by Xing-Wang Xu, Jie Zhang, Zai-Wen Guo, Ming-Ming Song, Ran Sun, Xin-Yuan Jin, Jian-Dong Su and Bing-Wei Sun (Suzhou, China - Ann Palliat Med.).
Beds, overlays and mattresses for treating pressure ulcers - PubMed
Abstract by Chunhu Shi, Jo C Dumville, Nicky Cullum, Sarah Rhodes, Asmara Jammali-Blasi, Victoria Ramsden and Elizabeth McInnes (UK, Australia - Cochrane Database Syst Rev.).
Autologous platelet-rich plasma repairs burn wound and reduces burn pain in rats - Oup.com
Abstract by Zhao-qi Ren, Bin Du, Hai-jiao Dong, Guang-hua Duan, Ai-cui Du, Yue Wang, Li-xia Zhao and Wen Shao (Journal of Burn Care & Research).
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Intraoperative Indocyanine Green Fluorescence Angiography Is Sensitive for Predicting Postoperative Wound Complications in Soft-Tissue Sarcoma Surgery - Lww.com
Article by Benjamin K. Wilke, Douglas S. Schultz, Maria T. Huayllani, Daniel Boczar, Aaron C. Spaulding, Courtney E. Sherman, Peter M. Murray and Antonio J. Forte (Jacksonville, USA - JAAOS).
ICG angiography has a high predictive value in the lower extremity for postoperative wound complications.
Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice - Nature.com
Article by Hans I-Chen Harn, Sheng-Pei Wang, Yung-Chih Lai, Ben Van Handel, Ya-Chen Liang, Stephanie Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, Stefan Kaemmer, Ming-Jer Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting-Xin Jiang and Cheng-Ming Chuong (USA, Taiwan - Nature Communications).
The authors propose a Turing model based on tissue stiffness that supports a two-scale tissue mechanics process: (1) establishing a morphogenetic field within the wound bed (mm scale) and (2) symmetry breaking of the epidermis and forming periodically arranged hair primordia within the morphogenetic field (μm scale).
Graphene Oxide-Based Stimuli-Responsive Platforms for Biomedical Applications - Mdpi.com
Article by Tejal V. Patil, Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly and Ki-Taek Lim (Chuncheon, Korea - Molecules).
This review describes the effects of different stimuli-responsive factors, such as pH, light, temperature, and magnetic and electric fields on GO-based materials and their applications.
Surgical debridement, maggot therapy, negative pressure wound therapy, and silver foam dressing revive hope for patients with diabetic foot ulcer: A case report - PubMed
Abstract by Naser Parizad, Kazem Hajimohammadi and Rasoul Goli (Urmia, Iran - Int J Surg Case Rep.).
Anti-inflammatory Nanotherapy Improves Outcomes After Urethral Surgery - Newswise.com
In the first study to evaluate the effects of anti-inflammatory nanofibers on wound healing following urethral surgery, scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago found that this innovative therapy promotes faster and complete healing, preventing prolonged or excessive inflammation that commonly leads to the need for more surgery.
A deeper understanding of how cells move and stick together - Eurekalert.org
The way cells adhere to surfaces is an important element in allowing them to form cohesive tissues. A new study looks at how cells stick to a surface and spread across it.
Improvement of treatment of complicated forms of diabetic foot syndrome - PubMed
Abstract by І Kozlovska, A Iftodiy, Ya Kulachek, V Grebeniuk and O Moskaliuk (Chernivtsi, Ukraine - Georgian Med News).
Content validation and usability of a chatbot of guidelines for wound dressing - PubMed
Abstract by Geicianfran da Silva Lima Roque, Rafael Roque de Souza, José William Araújo do Nascimento, Amadeu Sá de Campos Filho, Sérgio Ricardo de Melo Queiroz and Isabel Cristina Ramos Vieira Santos (Brazil - Int J Med Inform.).
Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing - Biomedcenteral.com
Article by Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang and Meng Ren (Guangzhou, China - Journal of Nanobiotechnology).
The hybrid hydrogel dressing may constitute an effective and biocompatible means of enhancing diabetic wound healing through effective silencing of the MMP-9 gene, and this hydrogel delivery system also offers a platform for in vivo delivery of siRNA for the treatment of other diseases.
Bacterial Autofluorescence Digital Imaging Guides Treatment in Stage 4 Pelvic Pressure Injuries: A Preliminary Case Series - Mdpi.com
Article by James B. Stiehl (Centralia, USA - Diagnostics).
Wound sepsis recurrence, adequate wound cleansing, and diagnosis of underlying periprosthetic total joint infection were confirmed with autofluorescence imaging showing regions of high bacterial load. By providing objective information at the point of care, imaging improved understanding of the bacterial infections and guided treatment strategies.
3D Printing New Skin by a Patient’s Bedside - Machinedesign.com
The Wake Forest Institute of Regenerative Medicine has developed a new mobile skin bioprinting system that can 3D print directly into a wound.
Negative Pressure Wound Therapy Devices With Instillation/Irrigation: A Technologic Analysis - PubMed
Abstract by Carolyn Crumley (Columbia, USA - J Wound Ostomy Continence Nurs.).
Wound surface area measurement methods - Sciencedirect.com
Abstract by Piotr Foltynski, Anna Ciechanowska and Piotr Ladyzynski (Warsaw, Poland - Biocybernetics and Biomedical Engineering).
ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging - Biomedcentral.com
Article by David M. Burmeister, Grace Chu-Yuan Chu, Tony Chao, Tiffany C. Heard, Belinda I. Gómez, Linda E. Sousse, Shanmugasundaram Natesan and Robert J. Christy (USA - Stem Cell Research & Therapy).
ASCs from burned individuals become increasingly oxidative and less glycolytic upon passaging when compared to ASCs from unburned patients. This increase in oxidative capacities was associated with ROS production in later passages.
Evaluation of wound healing effects of ginsenoside Rg1 and red ginseng extract in STZ-induced diabetic wound model: an in vivo pilot study - Biorxiv.org
Article by Ji Yun Lim, Young Suk Choi, Hye Rim Lee, Hye Min An and Youngkoo Lee (Asan, Korea).
The authors' results for Rg1 suggest its potential to promote diabetic wound healing by stimulating the production or activity of VEGF and TGF- β1 factors involved in the wound healing process.
Assessment of the Vanillin Anti-Inflammatory and Regenerative Potentials in Inflamed Primary Human Gingival Fibroblast - Hindawi.com
Article by Erica Costantini, Bruna Sinjari, Katia Falasca, Marcella Reale, Sergio Caputi, Srinivas Jagarlapodii and Giovanna Murmura (Chieti-Pescara, Italy - Mediators of Inflammation).
Vanillin shows a potential therapeutic interest as an inflammatory modulator molecule with novel application in periodontal regeneration and oral health.
The impact of resveratrol on skin wound healing, scarring, and aging - PubMed
Abstract by Andrzej Hecker, Marlies Schellnegger, Elisabeth Hofmann, Hanna Luze, Sebastian Philipp Nischwitz, Lars-Peter Kamolz and Petra Kotzbeck (Graz, Austria - Int Wound J.).
Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial - Bmj.com
Article by Brigid M Gillespie, Joan Webster, David Ellwood, Jennifer A Whitty, Kassam Mahomed, Vicki Clifton, Sailesh Kumar, Adam Wagner, Evelyn Kang and Wendy Chaboyer (Australia, UK).
Prophylactic closed incision NPWT for obese women after caesarean section resulted in a 24% reduction in the risk of SSI (3% reduction in absolute risk) compared with standard dressings.
Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing - Mdpi.com
Article by Simarjot Kaur Sandhu, Suneel Kumar, Jayant Raut, Mandeep Singh, Sandeep Kaur, Garima Sharma, Tomas L. Roldan, Sonia Trehan, Jennifer Holloway, Gabriella Wahler, Jeffrey D. Laskin, Patrick J. Sinko, Francois Berthiaume, Bozena Michniak-Kohn, Praveen Rishi, Narayanan Ganesh and Indu Pal Kaur (India, USA - Antioxidants).
The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing.
Pressure Ulcer Injury in Unstructured Clinical Notes: Detection and Interpretation - PubMed
Abstract by Mani Sotoodeh, Zelalem H Gero, Wenhui Zhang, Vicki Stover Hertzberg and Joyce C Ho (Atlanta, USA - AMIA Annu Symp Proc.).
Investigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract of Achyranthes aspera L. (Amaranthaceae) in Rats - Dovepress.com
Article by Teklie Mengie, Solomon Mequanente, Dereje Nigussie, Belete Legesse and Eyasu Makonnen (Ethiopia - Journal of Inflammation Research).
Data obtained from this study collectively indicated that a chloroform fraction of 80% methanol leaf extract of A. aspera possessed significant wound healing and anti-inflammatory activities.
Fibroblast growth factor in the treatment of burns: A systematic review - PubMed
Abstract by A Gragnani, E Tonarelli, V Chomiski, R Piccolo Daher and L M Ferreira (Brazil - Burns).
Antimicrobial and Wound Healing Properties of FeO Fabricated Chitosan/PVA Nanocomposite Sponge - Mdpi.com
Article by Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Arokia Vijay Anand Mariadoss and Myeong-Hyeon Wang (Chuncheon, Korea - Antibiotics).
This study aimed to develop a nanocomposite scaffold composed of chitosan, poly (vinyl alcohol), and phytogenic iron oxide nanoparticles, for accelerated anemia-associated diabetic wound healing.
Long‐Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy - Wiley.com
Article by Johannes Rebling, Maya Ben‐Yehuda Greenwald, Mateusz Wietecha, Sabine Werner and Daniel Razansky (Advanced Science).
Development of an automatic analysis framework enables the identification of key features of wound angiogenesis, including vessel length, diameter, tortuosity, and angular alignment. The approach offers a versatile tool for preclinical research in tissue engineering and regenerative medicine, empowering label‐free, longitudinal, high‐throughput, and quantitative studies of the microcirculation in processes associated with normal and impaired vascular remodeling, and analysis of vascular responses to pharmacological interventions in vivo.
Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and β-Catenin promotes wound healing - PubMed
Abstract by Ariel Diaz, Cynthia Martin-Jimenez, Yang Xu, Paola Merino, Yena Woo, Enrique Torre and Manuel Yepes (Atlanta, USA - J Cell Sci.).
Negative pressure wound therapy for surgical site infections: A systematic review and meta-analysis - PubMed
Abstract by Junru Gao, Yunyun Wang, Jingyu Song, Ze Li, Jianan Ren and Peige Wang (China - J Adv Nurs.).
Necrotic Wounds - Woundsource.com
Necrosis is the death of cells in living tissue caused by external factors such as infection, trauma, or toxins. As opposed to apoptosis, which is naturally occurring and often beneficial planned cell death, necrosis is almost always detrimental to the health of the patient and can be fatal.
How Scar Tissue Causes Pain and Tips for Management - Woundsource.com
Article by Cheryl Carver. Wounds heal by primary or secondary intention. Healing by primary intention occurs when wounds are approximated with sutures, staples, or other tools that will allow the wound to heal. Healing by secondary intention occurs when wounds are left to heal on their own by filling in with granulation, contraction, and epithelialize from the bottom up.
Therapeutic approach to electric burn with platelet rich plasma, grafts and hyperbaric oxygenation - PubMed
Abstract by Ricardo Murias, Yanina Court, Oscar Merbilhaá, Guillermo Fariña, Estela L Pace, Alejandra Biglia, María Cristina Igoillo, Juan Echezuri, Andrés Garone, Anahí Crocenzi and Mercedes Portas (Buenos Aires, Argentina - Medicina (B Aires)).
Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties - Mdpi.com
Article by Vladyslav Vivcharenko and Agata Przekora (Lublin, Poland - Applied Sciences).
The main emphasis of the presented review is put on the novel findings concerning modern pro-healing wound dressings that have contributed to the development of regenerative medicine. The article briefly describes the synthesis and modifications of biomaterials with bioactive compounds (including curcumin, essential oils, vitamins) to improve their pro-healing properties. The paper also summarizes biological effects of the novel wound dressings on the enhancement of skin regeneration.
The effects of whole-body vibration on wound healing in a mouse pressure ulcer model - Sciencedirect.com
Article by Nattaya Wano, Sompol Sanguanrungsirikul, Somboon Keelawat and Juraiporn Somboonwong (Bangkok, Thailand - Heliyon).
The authors' findings suggest that WBV has the potential to promote the healing process of stage II pressure ulcers, as evidenced by attenuation of wound inflammation and enhancement collagen deposition.
Timolol may be inexpensive, effective wound treatment - Healio.com
Timolol may be an effective and inexpensive treatment for wound healing, according to a poster presented at AAD VMX 2021.
Stem cell and tissue engineering approaches in pressure ulcer treatment - PubMed
Abstract Silvia Perez-Lopez, Marcos Perez-Basterrechea, Jose Maria Garcia-Gala, Eva Martinez-Revuelta, Angeles Fernandez-Rodriguez and Maria Alvarez-Viejo (Oviedo, Spain - J Spinal Cord Med.).
pdf (2,5 mB)!
Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects - Mdpi.com
Article by Kaushita Banerjee, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama and Harishkumar Madhyastha (India, Japan - International Journal of Molecular Sciences).
This review article provides an update on the various remedies with confirmed wound healing activities of metal-based nanoceutical adjuvanted agents and also other nano-based counterparts from previous experiments conducted by various researchers.
Study Examines Why Skin Lacerations May Be Slow to Heal, Even with Topical Antibiotics - Miragenews.com
When you get a cut, scrape or other minor skin laceration, doctors recommend that you take measures to ensure that the wound doesn’t get infected and heals properly. Many people opt to use over-the-counter medications, such as topical antibiotic ointments and liquids, to aid the repair process – and as commonly believed, promote healthy skin healing.
Treatment of Diabetic Foot Ulcers With Inforatio Technique to Promote Wound Healing: A Feasibility Trial - PubMed
Abstract by Sahar Moeini, Hans Gottlieb, Tue S Jørgensen, Malene R B Larsen and Stig Brorson (Denmark - Int J Low Extrem Wounds).
Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review - Biomedcentral.com
Article by Elodie Courtois, Wafa Bouleftour, Jean-Baptiste Guy, Safa Louati, René-Jean Bensadoun, Claire Rodriguez-Lafrasse and Nicolas Magné (France - BMC Oral Health).
The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM prevention and treatment, and more precisely to focus on the effect of PBM on tumor and healthy cells.
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