What’s the Connection Between Diabetes and Wound Healing? - Healthline.com
Diabetes is a result of your body’s inability to produce or use insulin. Insulin is a hormone that allows your body to turn glucose, or sugar, into energy. If your body has difficulty metabolizing glucose, it can lead to high blood sugar levels. This can affect your body’s ability to heal wounds.
Experts Highlight Emerging Biophysical Approaches to Advanced Wound Care - Generalsurgerynews.com
Article by Jenna Bassett. Wounds that heal improperly, incompletely or too slowly may lead to chronic wounds and morbidity that can impose a significant burden on the patient and provider. It comes as no surprise, then, that clinicians and researchers have developed advanced wound care technologies to support safe and optimized healing.
Boston University and Harvard Team Up to Remove Animal Testing from Wound Healing Study - Onegreenplanet.org
Article by Eliza Eskine. Boston University’s Department of Biomedical Engineering and Harvard’s Wyss Institute have teamed up to remove animals from a human wound healing process. In many cases, wound healing treatments are tested on animals, but this new research could remove them from the process.
Genetic Background and Kinetics Define Wound Bed Extracellular Vesicles in a Mouse Model of Cutaneous Injury - Mdpi.com
Article by Jin Qian, Dong Jun Park, Sophia Perrott, Parth Patel and Brian P. Eliceiri (USA, China - IJMS).
The authors' results establish a foundation for the parallel analysis of both immune cells and EVs with technologies that begin to address the heterogeneity of intercellular communication in the wound bed.
Wound Exudate: What Does This Color Mean for My Patient? - Woundsource.com
Article by Holly Hovan. When assessing and documenting a wound, it is important to note the amount and type of wound exudate (drainage). Using our senses is a large part of the initial wound assessment, followed by accurate documentation. Wound exudate or drainage gives us significant information about what is going on with the wound, all the way down to a cellular level, and it is one of the wound components that guide our topical treatments.
Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist - PubMed
Abstract by Jean L Tan, Blake Lash, Rezvan Karami, Bhavana Nayer, Yen-Zhen Lu, Celeste Piotto, Ziad Julier and Mikaël M Martino (Australia, USA - Commun Biol.).
Challenges of a Wound Care Center: Compliance and COVID-19 - Woundcarelearningnetwork.com
Poster by Marcus Speyrer.
Patient compliance is multifactorial and involves the dedication and commitment of many stakeholders. Their wound care center worked to improve patient communication, obtain physician referrals, and create a protocol to safely administer HBOT to COVID-19 patients with respiratory distress.
The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience - PubMed
Abstract by Ivan R Almeida, Pedro S Coltro, Henrique O C Gonçalves, Andrezza T Westin, Juliano B Almeida, Renan V K S Lima, Marcelo F Silva and Jayme A Farina Junior (São Paulo, Brazil - Wound Repair Regen.).
The Role of Intermittent Pneumatic Compression in the Treatment of Lower Extremity Chronic Wounds - PubMed
Abstract by Crystal James, So Youn Park, Mabel Chan, Nazanin Khajoueinejad, Denise Alabi, Jani Lee and John C Lantis 2nd (New York, USA - Surg Technol Int.).
AIRMESS - Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the use of Platelet-Rich Plasma (PRP), Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing - PubMed
Abstract by Pietro Gentile, Rubina Alves, John P Cole, Katarina Andjelkov, Thierry Van Helmelryck, Jonathan Fernandez, Angelo Trivisonno, Lemierre Guillaume, Alexis Verpaele, Patrick Tonnard, Jeremy Magalon, Guy Magalon and Sophie Menkes (Expert Opin Biol Ther.).
Intraoral Wound Dehiscence After Open Reduction Internal Fixation of Mandibular Fractures: A Retrospective Cohort Study - Woundresearch.com
Article by Shadia Abdelhameed Elsayed, Abdel Aziz Baiomy Abdullah, Najla Dar-Odeh and Alaa Abdelqader Altaweel (Jordan, Egypt - Wounds).
A small proportion of mandibular fracture patients are expected to have IOWD complication even if a meticulous and appropriate surgical technique is implemented. Intraoral wound dehiscence has a good prognosis and it may require a maximum of 2 weeks to obtain healing with secondary epithelization of the bared bony sites.
Using Topical Citric Acid to Treat an Infected Ulcerated Hemangioma in an Infant: A Case Study - Woundresearch.com
Article by Basavraj Nagoba, Milind Davane, Basavraj Warad, Nawab Jamadar and Ajay M. Gavkare (Latur, India - Wounds).
The efficacy, ease of application, and absence of notable adverse effects of using citric acid suggest it may be an effective option for the treatment of hemangiomas in children.
Fournier’s Gangrene With Subcutaneous Emphysema of the Thigh Caused by Air Inflow Associated With a Rectovaginal Fistula: A Case Report of Pseudo-gas Gangrene - Woundresearch.com
Article by Sho Yamakawa, Masaki Fujioka, Kiyoko Fukui, Haruka Matsuo, Miho Noguchi, Touta Kugiyama, Sou Sugimi, Hiroko Fukuda and Kenji Hayashida (Japan - Wounds).
In the present case, subcutaneous gas was not caused by gas gangrene but rather by air inflow from an RVF. Appropriate treatment of the RVF was necessary to avoid the exacerbation of Fournier’s gangrene and prevent necrosis spreading to the thigh.
Breaking the Cycle of Recurrent Diabetic Foot Ulceration: A Novel and Sustainable Offloading Modality to Treat Diabetic Foot Ulceration and Prevent Recurrence - Woundresearch.com
Article by Caroline Lyons (Birkenhead, UK - Wounds).
Implementation of a novel offloading device, which facilitates enhanced perfusion, monitors patient compliance with use, and can be continued upon wound resolution, was able to break the cycle of a recurrent DFU.
Diabetic Foot Ulcers and Osteomyelitis: Use of Biodegradable Calcium Sulfate Beads Impregnated With Antibiotics for Treatment of Multidrug-Resistant Organisms - Woundresearch.com
Article by Prashant Patil, Rajeev Singh, Apurva Agarwal, Rajiv Wadhwa, Aran Bal and Sanjay Vaidya (Mumbai, India - Wounds).
The use of locally released antibiotics from synthetic recrystallized calcium sulfate may offer significant benefits in the management of DFU infection compromised by poor circulation, polymicrobial growth, and associated renal and cardiac comorbidities.
Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.) - Mdpi.com
Article by Sariya Mapoung, Sonthaya Umsumarng, Warathit Semmarath, Punnida Arjsri, Pilaiporn Thippraphan, Supachai Yodkeeree and Pornngarm Limtrakul (Dejkriengkraikul) (Chiang Mai, Thailand - JoF).
The authors' results indicate that the wound-healing activities of A. auricula-judae (AAP) can be applied in an AAP-based product for wound management.
Advanced Wound Care Interventions for Non-Healing Wounds - Woundsource.com
Chronic and non-healing wounds are those that do not progress through the healing process in a timely or predicted manner. They are a global problem and are becoming harder to treat. Medicare estimates that over 8 million Americans have chronic wounds that cost the national health care system between $18.1 and $96.8 billion dollars annually.
Top 5 Digital Techniques to Reduce Hospital-Acquired Pressure Injuries - Nethealth.com
In this ebook, find out how five key ways digital techniques can reduce pressure injuries.
Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing - Mdpi.com
A discovery involving multiple teams from across Scripps Research has revealed a powerful new approach for treating diabetic foot ulcers, which affect millions of people in the US and often lead to serious complications.
By targeting a gene that controls tissue growth and regeneration, the scientists were able to boost cell division at the site of injury and repair chronic wounds quickly.
Study reveals new approach for treating diabetic foot ulcers - Medical.net
Article by Syafira Masri and Mh Busra Fauzi (Kuala Lumpur, Malaysia - Polymers).
This review aims to identify the limitations raised by using natural-based bioinks and the optimum temperature for various applied printing techniques. It is essential to ensure maintaining the acceptable printed scaffold property such as the optimum pore sizes and porosity that allow cell migration activity.
Does The Use of Ethyl Chloride Improve Patient-Reported Pain Scores with Negative Pressure Wound Therapy Dressing Changes? A Prospective, Randomized Controlled Trial - PubMed
Abstract by Jason C Tank, Gregory M Georgiadis, Jeffrey M Bair, Alexi Rice, Kristin O'Mara Gardner, John T Chen and Roberta E Redfern (Toledo, USA - J Trauma Acute Care Surg.).
An update on stem cells applications in burn wound healing - PubMed
Abstract by Sana Ullah, Sumaiya Mansoor, Aaima Ayub, Momina Ejaz, Hajrah Zafar, Fizza Feroz, Ayyaz Khan and Muhammad Ali (Islamabad, Pakistan - Tissue Cell).
Optimization of extracellular matrix production from human induced pluripotent stem cell‐derived fibroblasts for scaffold fabrication for application in wound healing - Wiley.com
Article by Milica Marinkovic, Rukmani Sridharan, Francesco Santarella, Avi Smith, Jonathan A. Garlick and Cathal J. Kearney (Journal of Biomedical Materials Research).
The authors show, for the first time, that combination of macromolecular crowders and ascorbic acid can scale up matrix production from a novel source of matrix, iPSF cells, by specifically boosting collagen and/or GAG deposition. In addition, iPSF matrix can successfully be used to produce functional porous scaffolds.
Intestinal Mucosal Wound Healing and Barrier Integrity in IBD-Crosstalk and Trafficking of Cellular Players - Frontiersin.org
Article by Katrin Sommer, Maximilian Wiendl, Tanja M. Müller, Karin Heidbreder, Caroline Voskens, Markus F. Neurath and Sebastian Zundler (Erlangen, Germany - Front. Med.).
Intestinal mucosal wound repair are key steps for achieving and maintaining MH, which is associated with beneficial clinical outcomes. However, the interplay as well as the trafficking characteristics of the most important cellular mediators like lymphocytes, neutrophils and monocytes/macrophages are not sufficiently characterized.
Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation - Frontiersin.org
Article by Harold F. Dvorak (Boston, USA - Front. Cell Dev. Biol.).
The data summarized here have led to a new hypothesis that can better explain the mechanisms by which VPF/VEGF acts in vivo to induce stroma formation; it also offers a possible explanation for the limited effectiveness of anti-VEGF cancer therapies. The hypothesis states that VPF/VEGF induces stroma primarily by way of its potent “VPF” function.
The effect of low-level laser therapy on diabetic foot ulcers: A meta-analysis of randomised controlled trials - PubMed
Abstract by Jing Huang, Jiangqiong Chen, Shuyuan Xiong, Jingui Huang and Zhiping Liu (Chongqing, China - Int Wound J.).
Epidermal graft encourages wound healing by down-regulation of gap junctional protein and activation of wound bed without graft integration as opposed to split-thickness skin graft - PubMed
Abstract by Muholan Kanapathy, Nadine Hachach-Haram, Nicola Bystrzonowski, David L Becker, Afshin Mosahebi and Toby Richards (UK, Singapore - Int Wound J.).
Systemic and topical administration of spermidine accelerates skin wound healing - Biomedcentral.com
Article by Daisuke Ito, Hiroyasu Ito, Takayasu Ideta, Ayumu Kanbe, Soranobu Ninomiya and Masahito Shimizu (Japan - Cell Communication and Signaling volume).
The authors' results indicate that treatment with SPD promotes skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response in wound sites. The administration of SPD might contribute to new effective treatments to accelerate skin wound healing.
Investigating the Impact of Collagen-Chitosan Derived from Scomberomorus Guttatus and Shrimp Skin on Second-Degree Burn in Rats Model - Sciencedirect.com
Article by Mohammad Javad Fatemi, Soheila Naderi Garahgheshlagh, Tayyeb Ghadimi, Shahla Jamili, Mohammad Reza Nourani, Ali Mohammad Sharifi, Mohsen Saberi, Naser Amini, Vahid Hosseinpour Sarmadi and Seyed Yasin Yazdi-Amirkhiz (Tehran, Iran - JSRM).
The authors' results suggest that the fish-extracted collagen-chitosan gel, as a new type of wound dressing, can accelerate burn wound healing. These findings provide the new insights for using the biological scaffolds in the human wound treatment.
Hyperbaric oxygen therapy reduces thermal wound complications and length of stay in hospitals, study finds - Iwoundnews.com
Hyperbaric oxygen therapy (HBOT) can reduce thermal wound complications, length of stay in hospitals due to thermal burns, intercellular adhesion molecule 1 (ICAM-1) mRNA gene expression, and ICAM-1 serum level, a case-control study published in Annals of Medicine and Surgery concludes.
Does exercise improve healing of diabetic foot ulcers? A systematic review - PubMed
Abstract by Morica M Tran and Melanie N Haley (Melbourne, Australia - J Foot Ankle Res.).
Comparing Costs of Wound Therapy in the Post-Acute Setting - Ajmc.com
Article by Laura Joszt. Wound care is costly, costing at least $28.1 billion annually for the Medicare population alone. Treating patients with wounds can be complex as they often have multiple comorbidities that impede wound healing.
Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings - Case Series - Mdpi.com
Article by Eyal Melamed, Patrick Kiambi, Dancan Okoth, Irena Honigber, Eran Tamir and Gadi Borkow (Israel, Kenya - Medicina).
The authors' findings are in line with previous animal and in vitro studies showing that copper plays a key role in angiogenesis and skin regeneration. These case reports support the notion that the use of copper oxide impregnated wound dressings may be an important intervention in the arsenal of wound treatment modalities, especially in hard to heal wounds.
Moisture-Associated Skin Damage: What It Is and What It Isn’t - Woundsource.com
Article by Dianne Rudolph. Moisture-associated skin damage (MASD) is a common problem for wound clinicians. It connotes a spectrum of skin damage caused by inflammation and erosion (or denudation) of the epidermis resulting from prolonged exposure to various sources of moisture and potential irritants. These can include urine, stool, perspiration, wound exudates, or ostomy effluent.
A Rule of Thumb for Evaluating Surface Areas of Chronic Wounds - PubMed
Abstract by Zexin Yao, Suiping He, Mengru Pang, Xiaoxuan Lei, Cuiwen Wu, Enqing Lin, Zhilong Cao, Wencai Jiang, Xiaobing Fu and Biao Cheng (China - Adv Skin Wound Care).
Does UV Light as an Adjunct to Conventional Treatment Improve Healing and Reduce Infection in Wounds? A Systematic Review - PubMed
Abstract Jeyanth Inkaran, Adam Tenn, Amanda Martyniuk, Forough Farrokhyar and Aleksa Cenic (Hamilton, Canada - Adv Skin Wound Care).
Spectrochemical and biochemical assay comparison study of the healing effect of the Aloe vera and Hypericum perforatum loaded nanofiber dressings on diabetic wound - PubMed
Abstract by Zozan Guleken, Joanna Depciuch, Hasan Ege, Gül İlbay, Cevriye Kalkandelen, Dilek Ozbeyli, Huri Bulut, Goksel Sener, Nevzat Tarhan and Serap Erdem Kuruca (Turkey, Poland - Spectrochim Acta A Mol Biomol Spectrosc.).
Preventing Recurrent Lower Extremity Wounds - Woundsource.com
Chronic and complex wounds of the lower extremity frequently recur. It is difficult to determine the precise recurrence rate across patients with different lower extremity wound types, including diabetic foot ulcers, arterial ulcers, pressure injuries, and venous ulcers. However, we know that recurrence rates are high; nearly 40% of patients with an ulcer will develop a recurrence within one year of healing. This percentage is 60% at three years after healing and 65% at the five-year mark.
Technological advancements have resulted in innovative solutions in wound care: Rajiv Gupta, 3M India - Indiatimes.com
The research in wound care has led to many new developments and shift from simple dressings to more advanced devices and products that support innovative healing solutions for both practitioners and patients across the care continuum.
Human Amnion Chorion Membrane Allografts in the Treatment of Chronic Diabetic Foot Ulcers: A Literature Review - PubMed
Abstract by Alisha Oropallo, Ashley Goodwin, MaKenzie Morrissey, Christina Del Pin and Amit Rao (Lake Sucess, USA - Adv Skin Wound Care).
Diverse Treatments for Deep Burn Wounds: A Case Report - PubMed
Abstract by Ling Zhou, Chunmei Liu, Yimei Luo, Fei Xiang and Huapei Song (Chongqing, China - Adv Skin Wound Care).
Deep tissue injury: a narrative review on the aetiology of a controversial wound - PubMed
Abstract by Matthew Wynn (Salford, UK - Br J Nurs.).
Effects of physical therapy on hyaluronan clearance and volume regulating hormones in lower limb lymphedema patients: A pilot study - PubMed
Abstract by Bianca Brix, Gert Apich, Andreas Rössler, Sebastian Walbrodt and Nandu Goswami (Austria - Sci Prog.).
Removing Necrosis From A Wound Bed Using Debridement - Woundcarelearningnetwork.com
Article by Karen Bauer. Wound debridement is a fundamental concept in the wound bed preparation model. Both the removal of necrosis from a wound bed and the process of debridement are crucial to infection prevention and wound healing. As research uncovers the role of biofilm in relation to the chronic inflammatory state and stalled wound healing, the discussion of debridement has resurfaced in the wound care community.
Promising Advancement in the Management of Complex Wounds - Woundcarelearningnetwork.com
7:11 video by Robert Kirsner. Umbilical Cord/Amniotic Membrane transplantation as an adjunct therapy is experiencing a rapid adoption rate in wound care applications.
Nutrition's Relationship to Wound Healing - Woundcarelearningnetwork.com
In this 4:01 video, Steve Bergquist discusses nutrition and wound healing. The delves into various topics such as, nutritional deficiency, nutrition processing with wounds, hormonal responses, and more.
Functional Dissection of CD26 and Its Pharmacological Inhibition by Sitagliptin During Skin Wound Healing - PubMed
Abstract by Yue Jiang, Yuan Yao, Jin Li, Yanling Wang, Jie Cheng and Yumin Zhu (Nanjing, China - Med Sci Monit.).
What’s the Connection Between Diabetes and Wound Healing? - Healthline.com
In people with diabetes, wounds tend to heal more slowly and progress more quickly, so it’s important to know what to look out for. Although cuts, grazes, scratches, and blisters can occur anywhere on the body, the feet are one of the most common places of injury. A small wound on the foot can quickly develop into a foot ulcer.
Clinical impact of a sub-epidermal moisture scanner: what is the real-world use? - PubMed
Abstract by Louisa Musa, Nicky Ore, Gillian Raine and Glenn Smith (UK - J Wound Care).
A new therapeutic protocol for the treatment of keloid scars: a retrospective study - PubMed
Abstract by David Boccara, Kevin Serror, Sarah Chatelain, Marc Chaouat, Maurice Mimoun and Laura Azoulay (Paris, France - J Wound Care).
Acellular fish skin enhances wound healing by promoting angiogenesis and collagen deposition - PubMed
Abstract by Hongchi Chen, Bohao Yin, Bin Hu, Baokun Zhang, Jingwen Liu, Yingzhe Jing, Zhiyuan Fan, Yuchen Tian, Xiaojuan Wei and Wei Zhang (China - Biomed Mater.).
Utilization of a Novel Negative Pressure Platform Wound Dressing on Surgical Incisions: A Case Series - PubMed
Abstract by Laura E Cooper, Megan C O'Toole, Kristopher L Fields, Elof K Eriksson and Rodney K Chan (USA - Plast Reconstr Surg Glob Open).
Advanced bandages for diabetic wound healing - Sciencemag.org
Article by Simon Matoori, Aristidis Veves and David J. Mooney (USA - Science Translational Medicine).
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, the authors present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. They discuss wound dressings tailored to the diabetic wound environment currently under development.
Cellular and molecular changes that predispose skin in chronic spinal cord injury to pressure ulcer formation - PubMed
Abstract by Georg Brunner, Meike Roux, Volker Böhm and Thomas Meiners (Germany - Int Wound J.).
Chronicity in Lower Extremity Wounds - Woundsource.com
Chronic wounds of the lower extremities impose an increasing burden on health care providers and systems, and they can have a devastating impact on patients and their families. These wounds include diabetic ulcers, venous ulcers, arterial ulcers, and pressure injuries. The estimated socioeconomic cost of chronic wounds is 2% to 4% of the health budget in Western countries.
Design and fabrication of electrospun Morinda citrifolia based nanofibrous scaffold as skin wound dressing material: In vitro and In silico analysis - PubMed
Abstract by Rajalakshmi Ekambaram, Moogambigai Sugumar, Elamathi Swaminathan, Arul Princy Micheal Raj and Sangeetha Dharmalingam (India - Biomed Mater.).
Inching Forward in Wound Measurement - Woundcarelearningnetwork.com
Article by Seth Snowden. Some disciplines in healthcare appear to be more physical than others. There are some areas of practice in which things are simply more tangible, hands on, and measurable. Wound care is one such wonderfully tactile specialty within the field of medicine.
How Do You Select a Wound Dressing? - Woundsource.com
Article by Cheryl Carver.
Let’s face it, dressing selection can be overwhelming for clinicians because of the plethora of products that are in the wound care market space. If only there were a multifunctional smart-dressing that could be used on every wound etiology. It would make managing wounds much easier.
Silver Nitrate and Wound Care: The Use of Chemical Cauterization - Woundsource.com
Silver nitrate is commonly used to chemically cauterize a wound for hemostasis after debridement or treatment of hypergranulation tissue. It is an inorganic and radiodense material with antimicrobial properties that can be used as a solution or an applicator stick.
Is Treating Patients With Stage 4 Pressure Ulcers With Vitamins A and C, Zinc, and Arginine Justified? - Woundresearch.com
Article by Kunaal Bafna, Tian Chen and Richard Simman. This study showed that routine treatment with vitamins A and C, zinc, and arginine in patients with stage 4 pressure ulcers is not justified.
Assessment of Outcomes After Limberg Flap Reconstruction for Scrotal Defects in Patients With Fournier’s Gangrene - Woundresearch.com
Article by Mehmet Dadaci, Mehmet Emin Cem Yildirim, Serhat Yarar and Bilsev Ince.
The authors's results suggest that use of the Limberg flap technique for scrotal reconstruction following FG has the important benefits of being easily harvested while providing tension-free repair and acceptable cosmetic results.
Ways to help scabs heal - Medicalnewstoday.com
A scab is a crusty plaque that forms over a wound. Taking steps to support the body’s healing process can help get rid of a scab.
A scab protects a wound while it heals. Keeping a wound clean and covering it with a layer of petroleum jelly, such as plain Vaseline, can retain moisture and prevent the wound from scabbing over.
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes - Mdpi.com
Article by Jordan Holl, Cezary Kowalewski, Zbigniew Zimek, Piotr Fiedor, Artur Kaminski,Tomasz Oldak, Marcin Moniuszko and Andrzej Eljaszewicz (Poland - Cells).
The authors review key differences between normal and chronic non-healing diabetic wounds, and elaborate on recent advances in wound healing treatments with a particular focus on biological dressings and their effect on key wound healing pathways.
Successful surgical resection and reconstruction of scrotal elephantiasis - PubMed
Abstract by Yuto Hattori, Naoki Hayata, Kenji Nakamura, Takeshi Takahashi, Kenji Mitsumori and Hiroyuki Ohnishi (Osaka, Japan - IJU Case Rep.).
Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems - Cell.com
Article by Luciana Fernandez, Ana Lucía Reviglio, Daniel A. Heredia, Gustavo M. Morales, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, Enrique L. Larghi, Andrea B. J. Bracca and Teodoro S. Kaufman (Argentina - Heliyon).
The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures.
Endoscopic negative pressure therapy (ENPT) in head and neck surgery: first experiences in treatment of postoperative salivary fistulas and cervical esophageal perforations - PubMed
Abstract by Jonathan Loeck, Hans-Jürgen von Lücken, Adrian Münscher, Christian Theodor Müller and Gunnar Loske (Hamburg, Germany - Eur Arch Otorhinolaryngol.).
Effects of implementing Pressure Ulcer Prevention Practice Guidelines (PUPPG) in the prevention of pressure ulcers among hospitalised elderly patients: a systematic review protocol - PubMed
Abstract by Amos Wung Buh, Hassan Mahmoud, Wenjun Chen, Matthew D F McInnes and Dean A Fergusson (Canada, China - BMJ Open).
The "Matrisome" reveals the characterization of skin keloid microenvironment - PubMed
Abstract by Shikun Zhang, Binghui Liu, Wenjuan Wang, Luye Lv, Dunqin Gao, Mi Chai, Mansheng Li, Zhihong Wu, Yunping Zhu, Jie Ma and Ling Leng (China - FASEB J.).
Netrins: Evolutionarily Conserved Regulators of Epithelial Fusion and Closure in Development and Wound Healing - PubMed
Abstract by Vishal Chaturvedi and Michael J Murray (Melbourne, Australia - Cells Tissues Organs).
Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing - Oup.com
Article by Yue Li, QingQing Leng, XianLun Pang, Huan Shi, YanLin Liu, SuSu Xiao, Ling Zhao, Ping Zhou and ShaoZhi Fu (Regenerative Biomaterials).
The authors conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.
Should weight-bearing activity be reduced during healing of plantar diabetic foot ulcers, even when using appropriate offloading devices? - PubMed
Abstract by Gustav Jarl, Jaap J van Netten, Peter A Lazzarini, Ryan T Crews, Bijan Najafi and Michael J Mueller (Sweden, Australia, The Netherlands, USA - Diabetes Res Clin Pract.).
Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota - Sciencedirect.com
Article by Michelle V. Mouritzen, Marija Petkovic, Katrine Qvist, Steen S. Poulsen, Susana Alarico, Ermelindo C. Leal, Louise T. Dalgaard, Nuno Empadinhas, Eugenia Carvalho and Håvard Jenssen (Denmark, Portugal, USA - Molecular Therapy - Methods & Clinical Development).
LFcinB treatment demonstrated noticeable positive effects on diabetic wound healing.
This Might Come as a Shock: Electricity Could Help Wound Healing - Interestingengineering.com
Article by Loukia Papadopoulos.
A new study is revealing that electricity may help in wound healing by increasing the permeability of blood vessels, which in turn, increases their capacity to carry white blood cells and oxygen. The remarkable work is taking place at Ohio State University.
Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate - Mdpi.com
Article by Nina Melnikova, Alexander Knyazev, Viktor Nikolskiy, Peter Peretyagin, Kseniia Belyaeva, Natalia Nazarova, Elena Liyaskina, Darina Malygina and Viktor Revin (Russia - Nanomaterials).
The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.
Electricity could help speed wound healing, new study shows - Mdpi.com
Electric stimulation may be able to help blood vessels carry white blood cells and oxygen to wounds, speeding healing, a new study suggests.
The study, published in the Royal Society of Chemistry journal Lab on a Chip, found that steady electrical stimulation generates increased permeability across blood vessels, providing new insight into the ways new blood vessels might grow.
What You Need to Know About Vacuum-Assisted Wound Closure (VAC) - Healthline.com
Vacuum-assisted closure (VAC) is a method of decreasing air pressure around a wound to assist the healing. It’s also referred to as negative pressure wound therapy.
During a VAC procedure, a healthcare professional applies a foam bandage over an open wound, and a vacuum pump creates negative pressure around the wound. This means the pressure over the wound is lower than the pressure in the atmosphere. The pressure pulls the edges of the wound together.
Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? - Biomedcentral.com
Article by Zhuoqun Fang, Penghong Chen, Shijie Tang, Aizhen Chen, Chaoyu Zhang, Guohao Peng, Ming Li and Xiaosong Chen (Fuzhou, China - Stem Cell Research & Therapy).
The authors not only discussed different sources of MSCs on the treatment of RISI both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields.
What’s the Connection Between Diabetes and Wound Healing? - Healthline.com
Diabetes is a result of your body’s inability to produce or use insulin. Insulin is a hormone that allows your body to turn glucose, or sugar, into energy. If your body has difficulty metabolizing glucose, it can lead to high blood sugar levels. This can affect your body’s ability to heal wounds.
Synthesis and Characterization of Exopolysaccharide Encapsulated PCL/Gelatin Skin Substitute for Full-Thickness Wound Regeneration - Mdpi.com
Article by Ahmad Hivechi, Peiman Brouki Milan, Khashayar Modabberi, Moein Amoupour, Kaveh Ebrahimzadeh, Amir Reza Gholipour, Faezeh Sedighi, Naser Amini, S. Hajir Bahrami, Alireza Rezapour, Masoud Hamidi and Cédric Delattre (Iran, France - Polymers).
In vivo implantation of nanofiber webs on the full-thickness wound on rat models displayed a faster healing rate when EPS was loaded into a nanofiber. These results suggest that the produced EPS can be used for skin tissue engineering applications.
Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold - Nature.com
Article by Amnah Asiri, Syafiqah Saidin, Mohd Helmi Sani and Rania Hussien Al-Ashwal (Johor Bahru, Malaysia).
The in vivo studies showed that compared to the control and single PVA-GFs nanofiber, the mix and multilayer scaffolds gave a much more wound reduction at day 7 with better wound repair at day 14–21, which indicated to enhancing tissue regeneration, thus, could be a projected as a suitable burn wound dressing scaffold.
Principles of Fibrinogen Fiber Assembly In Vitro - PubMed
Abstract by Stephani Stamboroski, Arundhati Joshi, Paul-Ludwig Michael Noeske, Susan Köppen and Dorothea Brüggemann (Germany - Macromol Biosci.).
Reconstruction of an Octogenarian Major Pretibial Degloving Injury Utilizing Negative Pressure Wound Therapy and Subsequently Combining Fenestrated-Type Artificial Dermis Without Skin Grafting - PubMed
Abstract by Wei-Chung Hung, Maria Chicco, Tony Chieh-Ting Huang and Hsu-Tang Cheng (Taiwan, UK, USA - Int J Low Extrem Wounds).
Evaluation of wound healing potential of Bhallatakadi Ghrita - cow ghee based polyherbal formulation: in-vivo excision and incision wound model - PubMed
Abstract by Sandesh R Wayal and Shailendra S Gurav (India - J Complement Integr Med.)
Using Machine Learning Technologies in Pressure Injury Management: Systematic Review - PubMed
Abstract by Mengyao Jiang, Yuxia Ma, Siyi Guo, Liuqi Jin, Lin Lv, Lin Han and Ning An (China - JMIR Med Inform.).
mTOR inhibitor INK128 promotes wound healing by regulating MDSCs - Biomedcentral.com
Article by Yi Li, Yujun Xu, Xinhan Liu, Xin Yan, Yue Lin, Qian Tan and Yayi Hou (Nanjing, China - Stem Cell Research & Therapy).
INK128 is potential to be developed as a clinical strategy to promote wound healing of diabetic patients.
Study on the Mechanism of Periplaneta americana Extract to Accelerate Wound Healing after Diabetic Anal Fistula Operation Based on Network Pharmacology - Hindawi.com
Article by Fengfei Wang, Shuai Li, Le Ma, Yuefei Geng, Yongmei Shen and Juanni Zeng (China - Evidence-Based Complementary and Alternative Medicine).
Periplaneta americana extract regulates multiple targets and multiple pathways to promote wound healing after diabetic anal fistula surgery.
Optical Coherence Tomography Angiography Monitors Cutaneous Wound Healing under Angiogenesis-Promoting Treatment in Diabetic and Non-Diabetic Mice - Mdpi.com
Article by Martin Pfister, Kornelia Schützenberger, Bhavapriya J. Schäfer, Stefan Puchner, Hannes Stegmann, Christine Hohenadl, Michael Mildner, Gerhard Garhöfer, Leopold Schmetterer and René M. Werkmeister (Austria, Singapore, Switzerland - Applied Sciences).
The authors' study suggests that OCT angiography has the potential to serve as a valuable preclinical research tool in studies investigating impaired vascular remodeling during wound healing and potential new treatment strategies.
Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing - Sciencedirect.com
Article by Alexandr Basov, Liliya Fedulova, Ekaterina Vasilevskaya, Ekaterina Trofimova, Nataliya Murashova and Stepan Dzhimakb (Russia - Saudi Journal of Biological Sciences).
Protein-peptide complex, obtained from Sus scrofa immune organs, can be not only potential biomaterial for promoting of wound regeneration, but also may be contemplated as basis for development new effective wound-healing agent in combination with lecithin liquid crystals.
Mesenchymal stem cells' seeded amniotic membrane as a tissue-engineered dressing for wound healing - PubMed
Abstract by Hamid Reza Aghayan, Motahareh Sheikh Hosseini, Mahdi Gholami, Fereshteh Mohamadi-Jahani, Akram Tayanloo-Beik, Sepideh Alavi-Moghadam, Moloud Payab, Parisa Goodarzi, Mohammad Abdollahi, Bagher Larijani and Babak Arjmand (Tehran, Iran - Drug Deliv Transl Res.).
Effect of Negative Pressure Wound Therapy in Electrical Burns - PubMed
Abstract by Viviana Gómez-Ortega, María José Vergara-Rodriguez, Bibiana Mendoza and Tatiana García (Bogotá, Colombia - Plast Reconstr Surg Glob Open).
Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway - Frontiersin.org
Article by Dali Gan, Qiyuan Su, Hanwen Su, Li Wu, Jun Chen, Bing Han and Meixian Xiang (China, USA - Front. Pharmacol.).
The authors' results demonstrate the safety and efficacy of burn ointment (BO) and suggest that activation of the PI3K/AKT/mTOR signaling pathway may play an important role in the promotion of wound healing by BO.
Predictive value of pressure ulcer risk for obstructive coronary artery disease - PubMed
Abstract by Yao Wang, Ran Chen, Jie Ding, Lu Yang, Jiaojiao Chen and Baotao Huang (Chengdu, China - Nurs Open).
Selected Biochemical Blood Parameters and a Risk of Pressure Ulcers in Patients Receiving Treatment in Intensive Care Units - PubMed
Abstract by Dariusz Bazaliński, Beata Midura, Anna Wójcik and Paweł Więch (Poland - Medicina (Kaunas)).
In-situ electrospinning of thymol-loaded polyurethane fibrous membranes for waterproof, breathable, and antibacterial wound dressing application - PubMed
Abstract by Yunpeng Yue, Xiaobao Gong, Wenling Jiao, Yang Li, Xia Yin, Yang Si, Jianyong Yu and Bin Ding (Shanghai, China - J Colloid Interface Sci.).
Photo-crosslinkable amniotic membrane hydrogel for skin defect healing - PubMed
Abstract by Qiang Zhang, Caiwang Chang, Chunyu Qian, Wanshu Xiao, Huajun Zhu, Jun Guo, Zhibing Meng, Wenguo Cui and Zili Ge (China - Acta Biomater.).
PD-L1+ neutrophils contribute to injury-induced infection susceptibility - PubMed
Article by Ajitha Thanabalasuriar, Abby J. Chiang, Christopher Morehouse, Margarita Camara, Shonda Hawkins, Ashley E. Keller, Adem C. Koksal, Carolina S. Caceres, Aaron A. Berlin, Nicholas Holoweckyj, Virginia N. Takahashi, Lily Cheng, Melissa de los Reyes, Mark Pelletier, Andriani C. Patera, Bret Sellman, Sonja Hess, Marcello Marelli, Chelsea C. Boo, Taylor S. Cohen and Antonio DiGiandomenico (USA, Canada).
This work provides evidence that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility.
Nanotherapeutic approach to treat diabetic foot ulcers using tissue-engineered nanofiber skin substitutes: A review - PubMed
Abstract by Hisham F Bahmad, Robert Poppiti and John Alexis (Miami, USA - Diabetes Metab Syndr.).
Negative pressure wound therapy for patients with hard-to-heal wounds: a systematic review - PubMed
Abstract by Alexandra Hj Janssen, Johannes A Wegdam, Tammo S de Vries Reilingh, Anne M Eskes and Hester Vermeulen (The Netherlands, Australia - J Wound Care).
Benefits of negative pressure wound therapy with instillation in the treatment of hard-to-heal wounds: a case series - PubMed
Abstract by Valérie Latouche and Hervé Devillers (Redon-Carentoir, France - J Wound Care).
Antibiofilm activity and cytotoxicity of silk sericin against Streptococcus mutans bacteria in biofilm: an in vitro study - PubMed
Abstract by Pornanong Aramwit, Supamas Napavichayanum, Prompong Pienpinijtham, Yousef Rasmi and Nipaporn Bang (Thailand, Iran - J Wound Care).
Review: Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification System - Woundsource.com
A diabetic foot ulcer (DFU) is a wound that has a high risk of becoming chronic, leading to amputation and, in some cases, even death. Currently, the Wagner and University of Texas classifications are used worldwide to assess the extent of diabetic foot lesions. The authors of this article believed that there was a lack of wound treatment principles based on both classification systems.
How Can You Prevent Medical Adhesive-Related Skin Injuries? - Woundsource.com
Article by Holly Hovan. Common top-down injuries are moisture-associated skin damage, skin tears, and medical adhesive–related skin injury (MARSI). In this blog, I focus on assessing, defining, and preventing MARSI.
Glucose-Triggered in situ Forming Keratin Hydrogel for the Treatment of Diabetic Wounds - PubMed
Abstract by Yansong Chen, Ying Li, Xuexia Yang, Zhangjun Cao, Huali Nie, Yonggang Bian and Guang Yang (Shanghai, China - Acta Biomater.).
Antimicrobial chitosan-agarose full polysaccharide silver nanocomposite films - PubMed
Abstract by Hossein Ghasemzadeh, Shiravan Afraz, Mohadeseh Moradi and Samira Hassanpour (Quazvin, Iran - Int J Biol Macromol.).
Granzyme B mediates impaired healing of pressure injuries in aged skin - Nature.com
Article by Christopher T. Turner, Juliana Bolsoni, Matthew R. Zeglinski, Hongyan Zhao, Tatjana Ponomarev, Katlyn Richardson, Sho Hiroyasu, Erin Schmid, Anthony Papp and David J. Granville (Vancouver, Canada).
Pressure injuries, also known as bedsores or pressure ulcers, are a major cause of death and morbidity in the elderly. The serine protease, Granzyme B (GzmB), contributes to skin aging and impaired wound healing. Aging is a major risk factor for PIs; thus, the role of GzmB in PI pathogenesis was investigated.
Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3 - Plos.org
Article by Katelyn J. McCann, Manoj Yadav, Mohammadali E. Alishahedani, Alexandra F. Freeman and Ian A. Myles.
The authors' findings reproduce the claims of many prior reports, suggest a potential role of folate metabolism in keloid pathogenesis, and present some of the first insights into the metabolic consequences of monogenic loss of STAT3 activity. Their work expands on the current literature to directly link JAK1/2, STAT3, and HIF1α to keloid pathology, folic acid responses, and Warburg physiology; however, other signaling pathways beyond these identified pathways are likely involved for each finding.
How Growth Factors Support Wound Healing - Woundsource.com
Growth factors and cytokines are secreted by the cells and are essential to the complex wound healing and tissue regeneration process. This process involves the interplay of growth factors with chemokines, cytokines, and other signaling molecules. Although there have been numerous advances that have increased our understanding of wound healing, the exact tissue regeneration mechanisms following an injury have yet to be determined.
Hydrogels Promote Healing Better than Traditional Bandages - Hospimedica.com
A new review suggests that hydrogel dressings, which are antibacterial, biodegradable, responsive, and injectable, can help heal wounds faster and better than current options.
Collagen Peptides Derived from Sipunculus nudus Accelerate Wound Healing - Mdpi.com
Article by Haisheng Lin, Zhihong Zheng, Jianjun Yuan, Chaohua Zhang, Wenhong Cao and Xiaoming Qin (China - Molecules).
The authors' results indicate that SNCP possessed excellent activity of accelerating wound healing and inhibiting scar formation, and its mechanism was closely related to reducing inflammation, improving collagen deposition and recombination and blockade of the TGF-β/Smads signal pathway.
Bedsores or pressure ulcers: What you need to know - Medicalnewstoday.com
Pressure sores, or bedsores, can develop if a person spends a long time in the same position. Also known as pressure ulcers, these sores form due to lasting pressure on specific areas of the body. They can develop anywhere, but the bony parts of the elbows, knees, heels, tailbone, and ankles are often more susceptible.
What Is Limb Salvage? - Verywellhealth.com
Article by Sherry Christiansen. Limb salvage is a surgical procedure to save a limb (usually one of the lower extremities) that is at high risk of amputation. The need for limb salvage can result from several different underlying causes, including various types of trauma, diabetes, vascular disease, cancer, or neuropathy.
Negative-pressure wound therapy in combination with bronchial occlusion to treat bronchopleural fistula: a case report - PubMed
Abstract by Masashi Iwasaki, Masanori Shimomura and Tsunehiro Ii (Kyoto, Japan - Surg Case Rep.).
What to know about skin ulcers - Medicalnewstoday.com
A skin ulcer is an open wound that develops on the skin as a result of injury, poor circulation, or pressure. Skin ulcers can take a very long time to heal. If left untreated, they can become infected and cause other medical complications.
Antioxidant and Anti‐Inflammaging Ability of Prune (Prunus spinosa L.) Extract Result in Improved Wound Healing Efficacy - Mdpi.com
Article by Sofia Coppari, Mariastella Colomba, Daniele Fraternale, Vanessa Brinkmann, Margherita Romeo, Marco Bruno Luigi Rocchi, Barbara Di Giacomo, Michele Mari, Loretta Guidi, Seeram Ramakrishna,
Natascia Ventura and Maria Cristina Albertini (Italy, Germany, Singapore - Antioxidants).
PSF extract antioxidant and anti-inflammaging abilities result in improved wound healing capacity, thus suggesting that PSF might be helpful to improve the quality of life for its beneficial health effects.
Therapeutic role of extracellular vesicles derived from stem cells in cutaneous wound models: A systematic review - PubMed
Abstract by Razieh Dalirfardouei, Aida Gholoobi, Mehrangiz Vahabian, Elahe Mahdipour and Fahimeh Afzaljavan (Iran - Life Sci.).
3D Scaffolds in the Treatment of Diabetic Foot Ulcers: New Trends vs Conventional Approaches - PubMed
Abstract by Katie Glover, Alexandros Ch Stratakos, Aniko Varadi and Dimitrios A Lamprou (UK - Int J Pharm.).
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches - Mdpi.com
Article by Frederik Schlottmann, Vesna Bucan, Peter M. Vogt and Nicco Krezdorn (Hannover, Germany - Medicina).
The purpose of this article is to review the achievements in burn surgery with regards to skin allotransplantation in recent years.
Scale-up of a Composite Cultured Skin using a novel Bioreactor Device in a Porcine Wound Model - PubMed
Abstract by Bronwyn L Dearman and John E Greenwood (Adelaide, Australia - J Burn Care Res.).
Lymph Node to Vein Anastomosis (LNVA) for lower extremity lymphedema - PubMed
Abstract by Chang Sik Pak, Hyunsuk Peter Suh, Jin Geun Kwon, Min-Jeong Cho and Joon Pio Hong (South Korea, USA - J Plast Reconstr Aesthet Surg.).
Current Update of Collagen Nanomaterials - Fabrication, Characterisation and Its Applications: A Review - Mdpi.com
Article by Samantha Lo and Mh Busra Fauzi (Kuala Lumpur, Malaysia - Pharmaceutics.)
Nano collagen can be applied in various medical fields involving bioscaffold insertion or fillers for wound healing improvement; skin, bone, vascular grafting, nerve tissue and articular cartilage regeneration as well as aiding in drug delivery and incorporation for cosmetic purposes.
Remote Wound Care - Woundresearch.com
Article by Laura Bolton.
With the increasing global presence of and reliance on smartphones, featuring high-resolution digital photography and wireless, high-speed Internet, patients with wounds and point-of-care wound professionals are increasingly engaged in remote wound management and surveillance.
Challenges of a Wound Care Center: Compliance and COVID-19 - Woundcarelearningnetwork.com
Poster by Marcus Speyrer.
Patient compliance is multifactorial and involves the dedication and commitment of many stakeholders. Their wound care center worked to improve patient communication, obtain physician referrals, and create a protocol to safely administer HBOT to COVID-19 patients with respiratory distress.
In vitro and in vivo evaluation of a nanofiber wound dressing loaded with melatonin - Sciencedirect.com
Abstract by Tahereh Mirmajidi, Faraz Chogan, Ali Hossein Rezayan and Ali Mohammad Sharifi (Iran, Malaysia - International Journal of Pharmaceutics).
pdf (1,2 mB)!
Keratinocytes Migration Promotion, Proliferation Induction, and Free Radical Injury Prevention by 3-Hydroxytirosol - Mdpi.com
Article by Mario Abate, Marianna Citro, Simona Pisanti, Mariella Caputo and Rosanna Martinelli (Salerno, Italy - International Journal of Molecular Sciences).
The authors' study highlighted novel pharmacological properties of HT, providing the first evidence of its capability to induce keratinocyte migration and proliferation required for healing processes and re-epithelialization.
Preclinical assessment of stem of Nicotiana tabacum on excision wound model - PubMed
Abstract by Yash Sharma, Amritpal Kaur, Rohit Bhardwaj, Nidhi Srivastava, Manisha Lal, Swati Madan and Kumud Bala (India - Bioorg Chem.).
Collagen based electrospun materials for skin wounds treatment - PubMed
Abstract by A Hernández-Rangel and E San Martin-Martinez (Mexikóváros, Mexikó - J Biomed Mater Res A.).
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