Purified exosomal product accelerates wound healing in preclinical models - News-medical.net
Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds.
Screening of Antioxidative Properties and Inhibition of Inflammation-Linked Enzymes by Aqueous and Ethanolic Extracts of Plants Traditionally Used in Wound Healing in Poland - Mdpi.com
Article by Marta Mainka, Monika E. Czerwińska, Ewa Osińska, Maria Ziaja and Agnieszka Bazylko (Poland - Antioxidants).
The study of composition showed that the main components of the tested extracts were flavonoids, such as luteolin, apigenin, kaempferol, and quercetin derivatives, as well as caffeoylquinic acids, caffeic acid, and its conjugates.
Comparison between PRP and PRFM on FTSG healing profile: Macroscopic, microscopic and ELISA evaluation - Sciencedirect.com
Article by Mirta Hediyati Reksodiputro, Muhammad Thaufiq Siddiq Boesoirie, Dondin Sajuthi, Sandi Iljanto and Mikhael Yosia (Indonesia - Annals of Medicine and Surgery).
This study observed that both PRFM and PRP as autologous platelet preparation accelerate wound healing in FTSG, with PRFM being superior due to the higher number of PMN, macrophage, and fibroblast.
An unusually painful leg ulcer in an 81-year-old patient: an interdisciplinary challenge - PubMed
Abstract by J Pfeifer, H Sairawan, M Wegener, S Philippou and K Meletiadis (Duisburg, Germany - Internist (Berl.)).
EWMA research grants supported by Convatec - Ewma.org
EWMA and Convatec are partnering this year to support three grants available to healthcare professionals. The goal of this initiative is to support the use of new technologies in wound management and/or good communication and safety in clinical practice.
Current operative management and therapeutic algorithm of lymphedema in the lower extremities - PubMed
Abstract by Savitha Ramachandran, Khong-Yik Chew, Bien-Keem Tan and Yur-Ren Kuo (Singapore, Taiwan - Asian J Surg.).
Identifying the Risk Factors Associated with Nursing Home Residents' Pressure Ulcers Using Machine Learning Methods - PubMed
Abstract by Soo-Kyoung Lee, Juh Hyun Shin, Jinhyun Ahn, Ji Yeon Lee and Dong Eun Jang (Korea, USA - Int J Environ Res Public Health).
Nurses' Knowledge and Attitudes towards Prevention of Pressure Ulcers - PubMed
Abstract by Beáta Grešš Halász, Anna Bérešová, Ľubomíra Tkáčová, Dagmar Magurová and Ľubomíra Lizáková (Slovakia - Int J Environ Res Public Health).
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Interpretation of Near-Infrared Imaging in Acute and Chronic Wound Care - Mdpi.com
Article by Jonathan Arnold and Valerie L. Marmolejo (USA - Diagnostics).
The objective of this paper is to educate providers on the correct interpretation of this point-of-care imaging modality in day-to-day wound-care practice to guide clinical decision-making for rapid wound resolution.
Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics - Mdpi.com
Article by Katarína Valachová and Ladislav Šoltés (Bratislava, Slovakia - Molecules).
This review summarizes that these two biopolymers have a mutual impact on skin wound healing as skin wound dressings and carriers of remedies.
Initial Experience Combining Negative Pressure Wound Therapy with Autologous Skin Cell Suspension and Meshed Autografts - Oup.com
Article by Bonnie C Carney, Laura S Johnson, Jeffrey W Shupp and Taryn E Travis (Washington, USA - Journal of Burn Care & Research).
The success of autologous split-thickness skin grafts (STSGs) in the treatment of full thickness burns is often dependent on the dressing used to secure it. Tie-over bolsters have been used traditionally, however, they can be uncomfortable for patients and preclude grafting large areas in one definitive operation.
Benefits of sucrose octasulfate (TLC-NOSF) dressings in the treatment of chronic wounds: a systematic review - PubMed
Abstract by Harikrishna Nair, N Venkateshwaran, Selva Seetharaman S, Wuquan Deng, Apinan Uthaipaisanwong and Emilio Galea (Malaysia, India, China, Thailand, Singapore - J Wound Care).
Wound Exudate: What Does This Color Mean for My Patient? - Woundsource.com
Article by Holly Hovan. When assessing and documenting a wound, it is important to note the amount and type of wound exudate (drainage). Using our senses is a large part of the initial wound assessment, followed by accurate documentation.
What Is a Kennedy Terminal Ulcer? - Woundsource.com
Article by Cathy Wogamon. Many questions arise and confusion develops when wound care providers mention Kennedy terminal ulcers (KTUs). Because these wounds are not frequently seen, and because they develop rapidly and observation ends abruptly with the death of the patient, wound care providers may have never observed a KTU, even in a long career in wound care.
Polyvinyl alcohol/chitosan composite hydrogels with sustained release of traditional Tibetan medicine for promoting chronic diabetic wound healing - PubMed
Abstract by Zuxin Wang, Shan Gao, Wanlin Zhang, Hanwen Gong, Kai Xu, Chao Luo, Wei Zhi, Xingyu Chen, Jianshu Li and Jie Weng (China - Biomater Sci.).
Review: The Safety of Punch Biopsies on Hard-to-Heal Wounds: A Large Multicentre Clinical Trial - Woundsource.com
A punch biopsy procedure is a useful and informative diagnostic technique that can be used to address all of the previously listed concerns and further focus the treatment of such challenging wounds. Although the punch biopsy seems as though it should be a standard diagnostic tool, many providers are hesitant to use it because it is an invasive procedure.
Wound healing, infection can be determined by genetics - Aninews.in
Researchers from Texas Tech's Department of Biological Sciences and Natural Science Research Laboratory recently determined that some genes have an association with the pathogens that infect chronic wounds and hinder the healing process. In a first-of-its-kind study, researchers have determined that genetics may play a role in how wounds heal.
pdf (2,9 mB)!
Enhanced Biological Activity of a Novel Preparation of Lavandula angustifolia Essential Oil - Mdpi.com
Article by Małgorzata Miastkowska, Tomasz Kantyka, Ewa Bielecka, Urszula Kałucka, Marta Kami´nska, Małgorzata Kucharska, Anna Kilanowicz, Dariusz Cudzik and Krzysztof Cudzik (Poland - Molecules).
The potential of the lavender oil to increase the production of VEGF, the most important angiogenic factor, with the in-house preparation performing significantly better in the in vitro cell models was identified.
Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview - Rsc.org
Article by Paola I. Campa-Siqueiros, Tomás J. Madera-Santana, María M. Castillo-Ortega, Jaime López-Cervantes, Jesús F. Ayala-Zavala and Elizabeth L. Ortiz-Vazquez (Mexico - RSC Advances).
The review analyses the potential use of co-electrospun nanofibers, with chitosan–PVA–eugenol in the core and gelatin in the shell as a wound dressing for diabetic skin ulcers.
Effects of Hydrogel With Enriched Sodium Alginate in Wounds of Diabetic Patients - PubMed
Abstract by Murilo Antonio Gustinelli Barbosa, André Oliveira Paggiaro, Viviane Fernandes de Carvalho, César Isaac and Rolf Gemperli (São Paulo, Brazil, Plast Surg Nurs.).
Antibacterial Effect of Copper Sulfide Nanoparticles on Infected Wound Healing - PubMed
Abstract by Yuan Liang, Jiale Zhang, Huahong Quan, Pei Zhang, Keteng Xu, Jinshan He, Yongchao Fang, Jingcheng Wang and Pengtao Chen (China - Surg Infect (Larchmt)).
Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation - Mdpi.com
Article by Kang-Hoon Kim, Ji Hoon Jung, Won-Seok Chung, Chang-Hun Lee and Hyeung-Jin Jang (Korea, Biomedicines).
The authors' findings show that FA is a novel therapeutic agent for wound healing that acts via inhibition of β-catenin in keratinocytes and by activation of Nrf2 in wound-induced inflammation.
pdf (240 kB)!
Does UV Light as an Adjunct to Conventional Treatment Improve Healing and Reduce Infection in Wounds? A Systematic Review - Lww.com
Article by Jeyanth Inkaran, Adam Tenn, Amanda Martyniuk, Forough Farrokhyar and Aleksa Cenic (Canada - Advances in Skin & Wound Care).
There is limited research on the utility of adjunctive UV therapy to improve wound healing outcomes in humans. The majority of literature included in this review supported improved wound healing outcomes with adjuvant UV therapy.
In mouse experiments, scientists unlock the key to scar-free skin healing - Statnews.com
Article by Megan Molteni. Scars. Like memories, we all have them. When you look at a scar you might see a tumble, a fight, an operation, a reminder of that time you succumbed to youthful stupidity, survived a traumatic incident, cheated death. But these marks aren’t just cosmetic keepsakes. Scar tissue is what happens when skin heals but it doesn’t regenerate.
Silver nanoparticles green synthesis via cyanobacterium Phormidium sp.: characterization, wound healing, antioxidant, antibacterial, and anti-inflammatory activities - PubMed
Abstract by N S Younis, N A El Semary and M E Mohamed (Al-Ahsa, Saudi Arabia - Eur Rev Med Pharmacol Sci.).
Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process - Mdpi.com
Article by Ipek Süntar, Sümeyra Çetinkaya, Emiliano Panieri, Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo and Luciano Saso (Turkey, Italy - Molecules).
This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
Peritoneal flap hernioplasty for repair of incisional hernias after orthotopic liver transplantation - Springer.com
Article by M. F. Nielsen, A. de Beaux, B. Stutchfield, J. Kung, S. J. Wigmore and B. Tulloh (UK, Denmark).
Repair of incisional hernias in patients following liver transplantation with the Peritoneal Flap Hernioplasty is a safe procedure associated with few complications and a very low recurrence rate. The authors propose this technique for the reconstruction of incisional hernias following liver transplantation.
Eliminating non-healing wounds: a review - PubMed
Abstract by Damien P Kuffler (Puerto Rico, USA - Regen Med.).
Fundamentals of Wound Healing - PubMed
Abstract by Christian L Stallworth (San Antonio, USA - Facial Plast Surg.).
Local and Regional Blocks for Complex Facial Wound Repair - PubMed
Abstract by Joy Obokhare (Amarillo, USA - Facial Plast Surg.).
Nanomaterials in Wound Healing and Infection Control - Mdpi.com
Article by Ali Pormohammad, Nadia K. Monych, Sougata Ghosh, Diana L. Turner and Raymond J. Turner (Canada, India - Antibiotics).
In this review, the authors present an overview of different types of nanomaterials explored specifically for wound healing properties combined with infection control.
Update in the management of lipedema - PubMed
Abstract by Isabel Forner-Cordero, Angeles Forner-Cordero and Győző Szolnoky (Spain, Hungary - Int Angiol.).
The 5-Factor Modified Frailty Index as a Predictor of 30-day Complications in Pressure Ulcer Repair - PubMed
Abstract by Jessica Luo, Gentry C Carter, Jayant P Agarwal and Alvin C Kwok (Salt Lake City, USA - J Surg Res.).
Efficacy of Dehydrated Human Amnion Chorion Membrane in the Treatment of Diabetic Foot Ulcers: A Review - PubMed
Abstract by Andrew S Au, Wai Y Leung and James W Stavosky (J Am Podiatr Med Assoc.).
Differentiation of Diabetic Foot Ulcers Based on Stimulation of Myogenic Oscillations by Transient Ischemia - Dovepress.com
Article by Agnieszka Los-Stegienta, Joanna Katarzynska, Anna Borkowska, Andrzej Marcinek, Katarzyna Cypryk and Jerzy Gebicki (Lodz, Poland - Vascular Health and Risk Management).
Impaired flowmotion responses to hypoxia induced by transient ischemia can be used for differentiation of diabetic foot ulcers and identification of cases with low prognosis for healing.
Wound healing and colon carcinogenesis. Enhancing effects of skin wounding on development of colon tumors induced by 1,2 Dimethylhydrazine in the rat - Scielo.br
Article by Júlio Lopes Sequeira, Shoiti Kobayasi and Maria Aparecida Marchesan Rodrigues (Acta Cir Bras.).
The present results suggest that wound healing enhances tumor development at a distant site, such as the colon, and this effect seems to be related to tumor histology.
Development of the BWAT-CUA Scale to Assess Wounds in Patients with Calciphylaxis - Mdpi.com
Article by Lisa J. Gould, Thomas E. Serena and Smeeta Sinha (USA, UK - Diagnostics).
BWAT-CUA, a newly developed tool for assessment of calciphylaxis wound severity and improvements over time, may be used in clinical research and in clinical practice.
pdf (300 kB)!
The need to debride - Lww.com
Article by Carol Calianno and Pamela Jakubek (Philadelphia, USA).
This article examines the process of debridement. When necrotic (yellow or gray) tissue is present in the wound bed, it prevents healing by providing a breeding ground for bacteria and prolonging the inflammatory phase of healing. Debridement, the removal of necrotic tissue and exudate, can help jump-start the healing process.
Long-Term Outcome Assessment Between Anti-Septic and Normal Saline for Negative Pressure Wound Therapy with Instillation - PubMed
Abstract by Dean Meshkin, Kenneth L Fan, Karina Charipova, Christine Hill, Karen K Evans, John S Steinberg, Paul A Kim and Christopher Attinger (USA - Adv Wound Care (New Rochelle)).
Multifunctional Ultrasmall AgNP Hydrogel Accelerates Healing of S. aureus Infected Wounds - PubMed
Abstract by Hanif Haidari, Richard Bright, Xanthe Strudwick, Sanjay Garg, Krasimir Vasilev, Allison J Cowin and Zlatko Kopecki (Australia - Acta Biomater.).
Concurrent validity of biofilm detection by wound blotting on hard-to-heal wounds - PubMed
Abstract by Adam Astrada, Gojiro Nakagami, Takeo Minematsu, Taichi Goto, Aya Kitamura, Yuko Mugita and Hiromi Sanada (Japan, USA - J Wound Care).
Use of TIME in treating a hard-to-heal localised scleroderma wound - PubMed
Abstract by Zhuang Hui-Ren, Yu Hai-Ping and Ma Li-Li (Shanghai, China - J Wound Care).
The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis - PubMed
Abstract by Hüseyin Sari, Semih Karaketir, Tolgar Lutfi Kumral, Muhammed Fatih Akgun, Berk Gurpinar, Deniz Hanci, Guler Berkiten and Yavuz Uyar (Turkey - Am J Otolaryngol.).
Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation - PubMed
Abstract Cinzia Pagano, Paola Calarco, Alessandro Di Michele, Maria Rachele Ceccarini, Tommaso Beccari, Sara Primavilla, Stefania Scuota, Fabio Marmottini, Daniele Ramella, Maurizio Ricci and Luana Perioli (Italy, USA - Int J Pharm.).
Histopathological effects of Aloe vera on wound healing process in penile fracture model: An experimental study - PubMed
Abstract by Kadir Turgay Akgül, Engin Doğantekin, Elif Özer, Mustafa Sirri Kotanoğlu, Yusuf Gökkurt and Sema Hücümenoğlu (Turk J Med Sci.).
Review: Prevalence of Pressure Ulcers in Long-Term Care: A Global Review - Woundsource.com
Pressure injuries (PIs) are prevalent in facilities where many of the patients are bedridden or confined to a wheelchair. PIs, also referred to as pressure ulcers or even bedsores, are caused by insufficient blood circulation to areas that are exposed to unrelieved, prolonged pressure. PIs are staged using the National Pressure Injury Advisory Panel (NPIAP) staging system as stages 1 to 4, based on their severity.
Tips for Depression Screening in Patients with Delayed Wound Healing - Woundsource.com
Article by Ryan Cummings. Although the impact of depression on all aspects of health and healing is well known and has been researched in progressively greater detail over the last decade, the role depression plays in prolonging healing time in chronic wounds is still rarely addressed fully.
The Role of Porphyrinoid Photosensitizers for Skin Wound Healing - Mdpi.com
Article by Mariana C. S. Vallejo, Nuno M. M. Moura, Ana T. P. C. Gomes, Ana S. M. Joaquinito, Maria Amparo F. Faustino, Adelaide Almeida, Idalina Gonçalves,Vanda Vaz Serra and Maria Graça P. M. S. Neves (Portugal - IJMS).
This review highlights the developments on the combination of PDT approach and skin wound healing using natural and synthetic porphyrinoids, such as porphyrins, chlorins and phthalocyanines, as PS, as well as the prodrug 5-aminolevulinic acid (5-ALA), the natural precursor of protoporphyrin-IX (PP-IX).
Efficacy of erythropoietin for wound healing: A systematic review of the literature - Sciencedirect.com
Article by Medet Toleubayev, Mariya Dmitriyeva, Saken Kozhakhmetov and Alina Sabitova (Kazakhstan, UK - Annals of Medicine and Surgery).
There were a limited number of studies and a great degree of heterogeneity of evidence due to differences in the course of concomitant illness, wound aetiology, and the time and dosing regimens adopted.
Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial - Sciencedirect.com
Article by Magnus S. Ågren, Lana Chafranska, Jens Ole Eriksen, Julie Lyng Forman, Morten J. Bjerrum, Peter Schjerling, Heidi F. Larsen, Elena Cottarelli, Lars N. Jorgensen and Lise Mette Rahbek Gjerdrum (Denmark, Italy - European Journal of Cell Biology).
The present human study demonstrates that quantitative immunohistochemistry can identify proteins involved in reepithelialisation and actions of external compounds. Increased dermal MT expression may contribute to the anti-inflammatory activities of zinc and increased MMP-1 levels to promote keratinocyte migration.
Pressure ulcer prevention-Results of a multicentre cross-sectional survey on hospital infrastructures and processes in acute hospitals and accident and emergency departments - PubMed
Abstract by Sandra Strube-Lahmann and Nils A Lahmann (Berlin, Germany - J Eval Clin Pract.).
pdf (2,5 mB)!
Wearable Sensors and Systems for Wound Healing-Related pH and Temperature Detection - Mdpi.com
Article by Ning Tang, Youbin Zheng, Xue Jiang, Cheng Zhou, Han Jin, Ke Jin, Weiwei Wu and Hossam Haick (China, Israel - Micromachines).
Challenges in the areas of sensing performance, infection identification threshold, large-area 3-dimensional detection, and long-term reliable monitoring in current wearable sensors/systems and emerging solutions are emphasized, providing critical insights into the development of wearable sensors and systems for wound healing monitoring and management.
What to know about open wound care - Medicalnewstoday.com
An open wound is any internal or external injury that leaves internal tissue exposed to the external environment. People can sometimes treat acute open wounds at home with medications and natural remedies. However, people should seek immediate medical attention for severe wounds that involve significant bleeding or broken bones.
Venous Leg Ulcers: A Review of Published Assessment and Treatment Algorithms - PubMed
Abstract by Stéphanie F Bernatchez, Jill Eysaman-Walker and Dot Weir (USA - Adv Wound Care (New Rochelle)).
Nanoliquid Dressing with Enhancing Anti-Infection Performance under the Moderate Photothermal Effect for Wound Treatment - PubMed
Abstract by Yaming Zhou, Hua Feng, Yanjie Jiang, Guanping Hua, Qiang Zhang, Sen Zeng, Wenlong Li, Lihuang Li, Ning Kang and Lei Ren (China - ACS Appl Mater Interfaces).
Silk films with nanotopography and extracellular proteins enhance corneal epithelial wound healing - Nature.com
Article by Yuncin Luo, Kai B. Kang, Rachel Sartaj, Michael G. Sun, Qiang Zhou, Victor H. Guaiquil and Mark I. Rosenblatt (Chicago, USA).
The authors conclude that silk film nanotopography in combination with collagen I constitutes a better substrate for corneal wound repair than either nanotopography or ECM alone.
Autocrine and Paracrine Effects of Vascular Endothelial Cells Promote Cutaneous Wound Healing - Hindawi.com
Article by Yang Lu, Yuhao Yang, Liling Xiao, Shenghong Li, Xuan Liao and Hongwei Liu (Guangzhou, China - BioMed Research International).
The authors' results clearly suggest that it is practicable and effective to promote wound healing with cytokines secreted by vascular endothelial cells in a mouse model.
Bandages made from crab shells speed healing - Nature.com
Article by Silke Schmidt. Seafood shells, such as from crab claws, contain a valuable material called chitin. Researchers have turned chitin into a new type of medical dressing that can boost wound healing.
Design and evaluation of a simulated wound management course for postgraduate year one surgery residents - Peerj.com
Article by Xin Qi, Rui He, Bing Wen, Qiang Li and Hongbin Wu (Beijing, China - PeerJ).
A szimuláció alapú elsajátítás beépült a szerzők által javasolt kurzus keretrendszerbe, elősegítve a PGY1-ek tanulási eredményét.
What does it mean when a scab turns yellow? - Medicalnewstoday.com
Scabs are a normal part of the body’s healing process, and they can sometimes turn yellow as a wound heals. In other cases, yellow scabs can be a characteristic symptom of certain skin infections, such as impetigo and cold sores.
The treatment challenges and limitation in high-voltage pediatric electrical burn at rural area: A case report - Sciencedirect.com
Article by Adi Basuki, Agustini Song, Nabila Viera Yovita, Kevin Leonard Suryadinata and Asian Edward Sagala (Indonesia - International Journal of Surgery Case Reports).
Lack of infrastructure, drugs, and trained personnel are some of the challenges that still exist in most rural areas. Thus, implementation of available standardized guidelines such as ANZBA, and giving similar training to personnel as well as providing feasible equipment followed by strict monitoring for the patient are needed to achieve maximum results.
Prophylactic negative-pressure wound therapy for prevention of surgical site infection in abdominal surgery: a nationwide cross-sectional survey - PubMed
Abstract by Elin Roos, Jonathan Douissard, Ziad Abbassi, Nicolas C Buchs, Christian Toso, Frédéric Ris and Jeremy Meyer (Sweden, Switzerland - Updates Surg.).
Novel positive allosteric modulator of protease-activated receptor 1 promotes skin wound healing in hairless mice - PubMed
Abstract by Yohan Seo, Yunkyung Heo, Sungwoo Jo, So-Hyeon Park, Chulho Lee, Jiwon Chang, Dong-Kyu Jeon, Tae Gun Kim, Gyoonhee Han and Wan Namkung (Korea - Br J Pharmacol.).
Combined Complex Skin Repair in Patient With Extensive Burns: A Case Report - PubMed
Abstract by Xingxin Gao, Min Zhang, Yuan Lin, Dehui Li and Liming Zhang (Nanning, China - J Burn Care Res.).
C-reactive Protein Levels in Plasma and Chronic Venous Ulcer Exudate of Persons Who Inject Drugs: A Pilot Study - Woundresearch.com
Article by Julia Paul, Thomas N. Templin, Nicholas J. Carruthers, Paul R. Burghardt, Ciara Ivanics, Paul M. Stemmer and Barbara Pieper (Wounds).
Plasma and exudate CRP levels were highly correlated. Exudate CRP levels decreased across time. Future large-scale wound healing studies should examine CRP levels over a longer duration and as they correlate to wound healing.
Efficacy of Closed Incision Negative Pressure Wound Therapy on Abdominal Donor Site After Free Flap Breast Reconstruction - Woundresearch.com
Article by Andres F. Doval, Vishwanath Chegireddy, Lauren Beal, Christian Arroyo-Alonso, Dmitry Zavlin, Aldona J. Spiegel and Warren A. Ellsworth (Wounds).
The use of ciNPWT on the abdominal donor site following DIEP flap breast reconstruction did not lower the incidence of wound dehiscence and wound infection. Different approaches are needed to decrease the incidence of donor site complications in abdominally based postmastectomy breast reconstruction.
Use of Pressure Mapping to Compare Two Operating Room Surfaces in the Supine With Bent Knees Position and the Supine in Lithotomy Position - Woundresearch.com
Article by Oleg Teleten, Jenni Prevatt, Lisa Peterson, Christopher Burleson, Machelle Wilson and Holly Kirkland-Kyhn (Wounds).
This study showed that use of the static, air-filled seat cushion on top of the standard OR surface resulted in superior pressure redistribution properties in both the supine with bent knees position and supine in lithotomy position compared with the standard OR surface alone.
Does Phototherapy Promote Wound Healing? Limitations of Blue Light Irradiation - Woundresearch.com
Article by Markus Denzinger, Manuel Held, Sabrina Krauss, Christian Knorr, Clemens Memmel, Adrien Daigeler and Wiebke Eisler (Wounds).
Blue light reduces keratinocyte proliferation and migration at high doses and therefore could negatively affect wound healing. Available irradiation devices for possible use in wound therapy should be critically scrutinized and evaluated with in vitro methods prior to clinical use.
Hydrosurgical Debridement Use Associated With Decreased Surgical Site-Related Readmissions: A Retrospective Analysis - Woundresearch.com
Article by Crystal Valerie James, Munir Patel, Nicole Ilonzo, Kojo Wallace, Jani Lee, Mabel Chan, Scott Ellis and John C. Lantis II (Wounds).
The present study found that the use of hydrosurgical debridement was associated with decreased SSI readmissions, which could potentially result in better wound care for the patient and possibly decreased health care costs because of a lower rate of readmissions. Further investigation of these 2 potential outcomes is necessary.
COVID-19 Associated Acute Limb Ischemia - Woundcarelearningnetwork.com
Infographic by Karen Bauer. Based on several case series, patients with COVID-19-associated acute limb ischemia (from arterial thrombosis) were generally > 60 years old, overweight, and had other chronic conditions like hypertension, peripheral arterial disease, and diabetes - just like many wound care patients!
Age-associated expression of p21and p53 during human wound healing - PubMed
Abstract by Chee W Chia, Cheryl A Sherman-Baust, Sara A Larson, Ritu Pandey, Roxanne Withers, Ajoy C Karikkineth, Linda M Zukley, Judith Campisi, Josephine M Egan, Ranjan Sen and Luigi Ferrucci (USA - Aging Cell).
The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study - PubMed
Abstract by Alperen S Bingoel, Nicco Krezdorn, Alexander Kaltenborn, Khaled Dastagir, Andreas Jokuszies, Tobias R Mett and Peter M Vogt (Germany - Wound Repair Regen.).
Histochemical and Morphometrical Analyses of Scarless Wound Healing in Mouse Fetal Model - PubMed
Abstract by Hiroshi Kawakami, Satoru Nishizawa, Atsuhiko Hikita and Kazuto Hoshi (Tokyo, Japan - Tokai J Exp Clin Med.).
Negative-pressure wound therapy combined with artificial dermis (Terudermis) followed by split-thickness skin graft might be an effective treatment option for wounds exposing tendon and bone: A retrospective observation study - PubMed
Abstract by Kuo-Feng Hsu, Yu-Lung Chiu, Hao Yu Chiao, Chun-Yu Chen, Chun-Kai Chang, Chien-Ju Wu, Yi-Jen Peng, Chih-Hsin Wang, Niann-Tzyy Dai, Shyi-Gen Chen and Yuan-Sheng Tzeng (Taiwan - Medicine (Baltimore)).
Researchers discover seaweed molecules can help heal wounds - Miragenews.com
Scientists from the ARC Centre of Excellence for Electromaterial Science (ACES) and University of Wollongong (UOW), in partnership with their seaweed bioinks collaborators Venus Shell Systems, have discovered that a molecular species known as ulvan aids wound healing in humans.
Modified vacuum-assisted closure (EndoVAC) therapy for treatment of pharyngocutaneous fistula: A case series and a review of the literature - PubMed
Abstract by Teresa Bernadette Steinbichler, Dolores Wolfram, Annette Runge, Roland Hartl, Daniel Dejaco, Tina Rauchenwald, Claus Pototschnig, Herbert Riechelmann and Volker Hans Schartinger (Innsbruck, Austria - Head Neck).
Potential cost-effectiveness of using adjunctive dehydrated human amnion/chorion membrane allograft in the management of non-healing diabetic foot ulcers in the United Kingdom - PubMed
Abstract by Julian F Guest, Leanne Atkin and Christopher Aitkins (UK - Int Wound J.).
Treatment of chronic diabetic foot ulcers with adipose-derived stromal vascular fraction cell injections: Safety and evidence of efficacy at 1 year - PubMed
Abstract by Michael H Carstens, Francisco J Quintana, Santos T Calderwood, Juan P Sevilla, Arlen B Ríos, Carlos M Rivera, Dorian W Calero, María L Zelaya, Nelson Garcia, Kenneth A Bertram, Joseph Rigdon, Severiano Dos-Anjos and Diego Correa (USA, Nicaragua, Spain - Stem Cells Transl Med.).
Bioinspired tough gel sheath for robust and versatile surface functionalization - Sciencemag.org
Article by Zhenwei Ma, Zhen Yang, Qiman Gao, VGuangyu Bao, Amin Valiei, Fan Yang, Ran Huo, Chen Wang, Guolong Song, Dongling Ma, Zu-Hua Gao and Jianyu Li (Montréal, Canada).
Sutures pervade surgeries, but their performance is limited by the mechanical mismatch with tissues and the lack of advanced functionality. Existing modification strategies result in either deterioration of suture’s bulk properties or a weak coating susceptible to rupture or delamination.
Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing - PubMed
Abstract by Mike Riepl (Bismarck, USA - Int J Pharm Compd.).
Ursolic acid-loaded lipid-core nanocapsules reduce damage caused by estrogen deficiency in wound healing - PubMed
Abstract by Bruna Carletto, Adriana Yuriko Koga, Andressa Novatski, Rubiana Mara Mainardes, Leandro Cavalcante Lipinski and Paulo Vitor Farago (Brazil - Colloids Surf B Biointerfaces).
Acceleration of cutaneous wound healing by Lucilia sericata maggots in diabetic Wistar rats - PubMed
Abstract by S Borkataki, R Katoch, P Goswami, A Bhat and D Chakraborty (India - Trop Biomed.).
Collagen Dressings: Types, Benefits, and Uses - Woundsource.com
Collagen is a natural fibrous protein of the extracellular matrix. It contains three proteins wrapped around each other to form a triple-helix structure. Collagen is a biocompatible structural protein that is ideal for tissue engineering and regenerative purposes.
Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs - PubMed
Abstract by Shuai Wei, Wei Wang, Li Li, Hao-Ye Meng, Chun-Zhen Feng, Yu-Ying Dong, Xi-Chi Fang, Qi-Qiang Dong, Wen Jiang, Hai-Li Xin, Zhan-Zhen Li and Xin Wang (China - Mil Med Res.).
Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem Cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes - Mdpi.com
Article by Margherita Pomatto, Chiara Gai, Federica Negro, Massimo Cedrino, Cristina Grange, Elena Ceccotti, Gabriele Togliatto, Federica Collino, Marta Tapparo, Federico Figliolini,Tatiana Lopatina, Maria Felice Brizzi and Giovanni Camussi (Italy - Int. J. Mol. Sci.).
The authors' results provide deeper comparative information on the cargo of ADSC-EVs and BMSC-EVs and the impact on regenerative processes essential for diabetic wound healing.
Ways to help scabs - Medicalnewstoday.com
A scab is a crusty plaque that forms over a wound. Taking steps to support the body’s healing process can help get rid of a scab.
Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study - Biomedcentral.com
Article by Mohammad Saeid Salami, Gholamreza Bahrami, Elham Arkan, Zhila Izadi, Shahram Miraghaee and Hadi Samadian (Kermanshah, Iran - BMC Complementary Medicine and Therapies).
In the current study, the authors integrated the physicochemical properties of Poly (caprolactone)/ Poly (vinyl alcohol)/Collagen (PCL/PVA/Col) nanofibers with the biological activities of Momordica charantia pulp extract to develop an efficient wound dressing. The electrospinning method was applied to fabricate the nanofibers, and the prepared wound dressings were thoroughly characterized.
pdf (6,7 mB)!
Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing - Mdpi.com
Article by Justyna Sawicka, Emilia Iłowska, Milena Deptuła, Paweł Sosnowski, Piotr Sass, Katarzyna Czerwiec, Klaudia Chmielewska, Aneta Szymanska, Zuzanna Pietralik-Molinska, Maciej Kozak, Paweł Sachadyn, Michał Pikuła and Sylwia Rodziewicz-Motowidło (Poland - International Journal of Molecular Sciences).
In vivo experiments in a dorsal skin injury model in mice indicated that two tested peptides moderately promote tissue repair in their free form. The authors' research proves that peptide fibrils can be a druggable form and a scaffold for active peptides.
Treatment of chronic diabetic foot ulcers with adipose‐derived stromal vascular fraction cell injections: Safety and evidence of efficacy at 1 year - Stemcellsjournal.com
Article by Michael H. Carstens, Francisco J. Quintana, Santos T. Calderwood, Juan P. Sevilla, Arlen B. Ríos, Carlos M. Rivera, Dorian W. Calero, María L. Zelaya, Nelson Garcia, Kenneth A. Bertram, Joseph Rigdon, Severiano Dos‐Anjos and Diego Correa (Stem Cells Translational Medicine).
The authors' results indicate that SVF can be safely used to treat chronic DFU, with evidence of efficacy (wound healing) and mechanisms of action that include vascular repair and/or angiogenesis.
What to eat to promote wound healing - Ajmc.com
Article by Jaime Rosenberg. According to a recent review, data suggest mast cells have an important role in tissue homeostasis and wound healing, with mass cell dysregulation potentially leading to fibrotic disease.
Research Highlights Mast Cell Involvement in cGVHD - Explica.co
There are nutrients that are very important for wound healing. Although there are small cuts, scratches or scrapes that in healthy people heal quickly. Some wounds may require a higher protein intake in addition to certain vitamins and minerals to promote healing.
Insulin, but Not Metformin, Supports Wound Healing Process in Rats with Streptozotocin-Induced Diabetes - Dovepress.com
Article by Mateusz Mieczkowski, Beata Mrozikiewicz-Rakowska, Tomasz Siwko, Magdalena Bujalska-Zadrozny, Anna de Corde-Skurska, Renata Wolinska, Emilia Gasinska, Tomasz Grzela, Piotr Foltynski, Michal Kowara, Zofia Mieczkowska and Leszek Czupryniak (Warsaw, Poland - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy).
The authors' results suggest that an insulin-based treatment is more beneficial than metformin, in terms of accelerating the wound healing process in an animal model of streptozocin-induced diabetes.
pdf (160 kB)!
Special Issue: Application of Extracellular Matrix in Regenerative Medicine - Mdpi.com
Article by Neill J. Turner (Pittsburgh, USA - Applied Sciences).
The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.
Researching Cell Migration Assay Applications - News-medical.net
In order to study a wide variety of biological processes, understanding cellular invasion and migration is crucial. Researchers can investigate processes as varied as wound healing and metastasis by observing the directed rate of movement of cells in response to mechanical or chemical signals.
Comparison of Interface Pressures and Subjective Comfort of Pressure-Relieving Overlays on the Operating Table for Healthy Volunteers - PubMed
Abstract by Min Jung Han and Sangjin Ko (Korea - Int J Environ Res Public Health).
Analysis of Rinsing Fluid during Negative Pressure Wound Therapy with Instillation: A Potential Monitoring Tool in Acute and Chronic Wound Treatment. A Pilot Study - PubMed
Abstract by Christian D Taeger, Stefan Wallner, Teresa Martini, Daniel Schiltz, Andreas Kehrer, Lukas Prantl and Niklas Biermann (Regensburg, Germany - Cells).
Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers - Sciencedirect.com
Article by Shumin He, Caiyi Liang, Cailan Yi and Miaoli Wu (Guangdong, China - Diabetes Research and Clinical Practice).
The combination of MWD and CDO was effective in promoting healing and preventing infection of DFUs, which holds a potential to be a new strategy for the treatment of this critical clinical condition.
pdf (720 kB)!
Historical Evolution of Skin Grafting - A Journey through Time - Mdpi.com
Article by Michael Kohlhauser, Hanna Luze, Sebastian Philipp Nischwitz and Lars Peter Kamolz (Graz, Austria - Medicina).
The present paper gives an overview about the evolution of skin grafting and its usage in burn care nowadays.
Lymphoedema and oedema in palliative care patients - PubMed
Abstract by Sinéad Cobbe (Limerick, Ireland - Br J Community Nurs.).
Use of Sponge-Foam Inserts in Compression Bandaging of Non-Healing Venous Leg Ulcers - PubMed
Abstract by Rica Tanaka, Hideaki Inoue, Takeru Ishikawa, Yuichi Ichikawa, Rumiko Sato, Azusa Shimizu and Hiroshi Mizuno (Japan - Ann Vasc Dis.).
A cut above the rest: oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics - Academic.oup.com
Abstract by Joel B Johnson, Daniel A Broszczak, Janice S Mani, Jack Anesi and Mani Naiker (Journal of Pharmacy and Pharmacology).
Traditional and advanced therapeutic modalities for wounds in the paediatric population: an evidence-based review - PubMed
Abstract by Stephanie A McNamara, Penelope A Hirt, Maximillian A Weigelt, Sonali Nanda, Valeria de Bedout, Robert S Kirsner and Lawrence A Schachner (Miami, USA - J Wound Care).
Enhanced wound healing using a 3D printed VEGFmimicking peptide incorporated hydrogel patch in a pig model - Iop.org
Article by MJ Jang, SK Bae, YS Jung, JC Kim, JS Kim, SK Park, JS Suh, SJ Yi, SH Ahn and JO Lim (Daegu, Korea).
VEGF peptide, which is slowly released from hydrogel patches, can promote cell viability, proliferation, and tubular structure formation. In addition, a pig skin wound model was used to evaluate the wound-healing efficacy of GelMA-VEGF hydrogel patches; the results suggest that the GelMA-VEGF hydrogel patch can be used for wound dressing.
The role of mechanical interactions in EMT - PubMed
Abstract by Ryan J Murphy, Pascal R Buenzli, Tamara Tambyah, Erik W Thompson, Honor Joy Hugo, Ruth E Baker and Matthew J Simpson (Australia, UK - Phys Biol.).
Light emitting diode-red light for reduction of post-surgical scarring: Results from a dose-ranging, split-face, randomized controlled trial - PubMed
Abstract by Alana Kurtti, Julie K Nguyen, Jeremy Weedon, Andrew Mamalis, Yi Lai, Natasha Masub, Amaris Geisler, Daniel M Siegel and Jared R Jagdeo (USA - J Biophotonics).
The Custom Total Contact Cast to Offload Foot Ulcers in the Presence of Biomechanical Deformities: A Case Report - PubMed
Abstract by Mohammad Junayed Khan, Anna Stoupine, Kamal Farha, Ji Hee Kim and Poovasit Klinoubol (New York, USA - Wound Manag Prev.).
Salvaging the Unsalvageable: Negative Pressure Wound Therapy for Severe Infection of Prosthetic Breast Reconstruction - PubMed
Abstract by Farid Meybodi, Negin Sedaghat, Elisabeth Elder, James French, Kristian Adams, Jeremy Hsu, Kavitha Kanesalingam and Meagan Brennan (Sydney, Australia - Plast Reconstr Surg Glob Open).
A Systematic Investigation of Models for Color Image Processing in Wound Size Estimation - Nature.com
Article by Filipe Ferreira, Ivan Miguel Pires, Mónica Costa, Vasco Ponciano, Nuno M. Garcia , Eftim Zdravevski, Ivan Chorbev and Martin Mihajlov (Portugal, North Macedonia, Slovenia - Computers).
The authors proposed that a method for measuring the wound area must implement different stages, including conversion to grayscale for further implementation of the threshold and a segmentation method to measure the wound area as the number of pixels for further conversion to metric units.
Comparative analysis of biofilm models to determine the efficacy of antimicrobials - PubMed
Abstract by E K Stuermer, M Besser, F Brill, M Geffken, I Plattfaut, A L Severing, V Wiencke, J D Rembe, E A Naumova, A Kampe, S Debus and R Smeets (Germany - Int J Hyg Environ Health).
Ozone oil promotes wound healing via increasing miR-21-5p-mediated inhibition of RASA1 - PubMed
Abstract by Wei-Rong Xiao, Meng Wu and Xiang-Rong Bi (Changsa, China - Wound Repair Regen.)
Experience with negative-pressure wound therapy with instillation in complex infected orthopaedic wounds - PubMed
Abstract by Ahmed H Elhessy, Arif R Chaudhry, Ahmed I Hammouda, Shawn D Giacobbe, Martin G Gesheff and Janet D Conway (USA, Egypt - Int Wound J.).
A cross-species analysis of systemic mediators of repair and complex tissue regeneration - Nature.com
Article by Julia Losner, Katharine Courtemanche and Jessica L. Whited (Cambridge, USA - npj Regenerative Medicine).
The authors consider studies performed in a diverse set of organisms, including vertebrates and invertebrates. Through analysis of systemic mediators of regeneration, they argue that increased investigation of these "systemic factors” could reveal novel insights that may pave the way for a diverse set of therapeutic avenues.
The potential role of genus tinospora in wound healing: a review - Nature.com
Article by Michele Fernandez, Naveen Kumar Shivashekaregowda and Yow Hui Yin (Selangor, Malaysia - International Journal of Pharmacy and Pharmaceutical Sciences).
Whereas T. crispais reported with wound healing activity through the elevated antioxidant enzymes and inflammation phase. Nevertheless, there is limited evidence on phytochemical constituents from plant extracts that contribute to the wound healing process and their underlying mechanisms.
Fibrotic enzymes modulate wound-induced skin tumorigenesis - PubMed
Abstract by Lisette Van Hove, Kim Lecomte, Jana Roels, Niels Vandamme, Hanna-Kaisa Vikkula, Isabelle Hoorens, Katia Ongenae, Tino Hochepied, Giacomo Donati, Yvan Saeys, Sven R Quist, Fiona M Watt, Geert van Loo and Esther Hoste (Belgium, Italy, UK, Germany - EMBO Rep.).
Use of a negative pressure wound therapy system over closed incisions option in preventing post-sternotomy wound complications - PubMed
Abstract by Carlotta Brega, Simone Calvi and Alberto Albertini (Cotignola, Italy - Wound Repair Regen.).
Wound healing activities in the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis - Sciencedirect.com
Article by Francyelle Borges Rosa de Moura, Bruno Antonio Ferreira, Simone Ramos Deconte, Breno Costa Landim, Allisson Benatti Justino, Andrea Aparecida de Aro, Foued Salmen Espindola, Rodney AlexandreFerreira Rodrigues, Daniele Lisboa Ribeiro, Fernandade Assis Araújo and Tatiana CarlaTomiosso (Brazil - Journal of Traditional and Complementary Medicine).
The ability to modulate essential parameters for accelerated and adequate healing as shown here suggests that the use of standardised extracts of M. ilicifolia and its fractions enriched in polyphenols may represent a therapeutic strategy for the treatment of wounds.
pdf (2,1 mB)!
Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs - Mdpi.com
Article by Enamul Haque Mojumdar, Lone Bruhn Madsen, Henri Hansson, Ida Taavoniku, Klaus Kristensen, Christina Persson, Anna Karin Morén, Rajmund Mokso, Artur Schmidtchen, Tautgirdas Ruzgas and Johan Engblom (Sweden, Denmark - Biomedicines).
Proper skin barrier function is paramount for our survival, and, suffering injury, there is an acute need to restore the lost barrier and prevent development of a chronic wound. The authors hypothesize that rapid wound closure is more important than immediate perfection of the barrier, whereas specific treatment may facilitate perfection. The aim of the current project was therefore to evaluate the quality of restored tissue down to the molecular level.
Have a Wound? Now Scientists Can 3D-Print Living Skin - Interestingengineering.com
Article by Loukia Papadopoulos. The first-of-its-kind system uses a patient's own cells to bioprint skin where it is needed most.
Durian fruit-derived gel bandage promotes wound healing - Globalspec.com
Article by Marie Donlon. Antibacterial gel bandages derived from durian fruit have been created by food scientists at Nanyang Technological University Singapore (NTU Singapore).
Tissue matters: In-vivo tissue properties of persons with spinal cord injuries to inform clinical models for pressure ulcer prevention - PubMed
Abstract by Justin Scott, Brian Sheridan, Rick Andrus, Nick Monday, Amy Selby and Tamara Reid Bush (USA - J Biomech.).
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