Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing - Wiley.com
Article by Vickie R. Driver, Kara S. Couch, Kristen A. Eckert MPhil, Gary Gibbons, Lorena Henderson, John Lantis, Eric Lullove, Paul Michael, Richard F. Neville, Lee C. Ruotsi, Robert J. Snyder, Fadi Saab and Marissa J. Carter (Wound Repair and Regeneration).
Levels 2–5 evidence reveals a paradigm shift in wound care towards a hybrid telemedicine and home healthcare model to keep patients at home to minimize the number of in-person visits at clinics and hospitalizations, with the exception of severe cases such as chronic limb-threatening ischemia. The use of telemedicine and home care will likely continue and improve in the postpandemic era.
Collagen-based formulations for wound healing: A literature review - PubMed
Abstract by Shubham Sharma, Vineet Kumar Rai, Raj K Narang and Tanmay S Markandeywar (India - Life Sci.).
Methicillin-resistant Macrococcus canis in a human wound - PubMed
Abstract by Geraldine Jost, Sybille Schwendener, Nadia Liassine and Vincent Perreten (Switzerland - Infect Genet Evol.).
Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real World Outcomes - PubMed
Abstract by Jessica Izhakoff Yellin, Julia Gaebler, Frank F Zhou, Timothy Niecko, Olivia Novins, Amelia Ockert, Darcy Krzynowek, Matthew G Garoufalis, Aliza M Lee and Robert G Frykberg (USA - Adv Wound Care (New Rochelle)).
The impact of the SARS-CoV-2 pandemic on the management of chronic limb-threatening ischemia and wound care - Mdpi.com
Article by Mariarosaria Galeano, Giovanni Pallio, Natasha Irrera, Federica Mannino, Alessandra Bitto, Domenica Altavilla, Mario Vaccaro, Giovanni Squadrito, Vincenzo Arcoraci, Michele Rosario Colonna, Rita Lauro and Francesco Squadrito (Messina, Italy - Pharmaceuticals).
All data obtained proved the ability of polydeoxyribonucleotide (PDRN) in promoting physiological tissue repair through adenosine A2A receptor activation and salvage pathway suggesting that PDRN has proven encouraging results in terms of healing time, wound regeneration and absence of side effects.
Construction of a Risk Prediction Model for Intraoperative Pressure Injuries: A Prospective, Observational Study - PubMed
Abstract by Zhihong Tang, Na Li and Jing Xu (Chengdu, China - J Perianesth Nurs.).
Is Treating Patients With Stage 4 Pressure Ulcers With Vitamins A and C, Zinc, and Arginine Justified? - PubMed
Abstract by Kunaal Bafna, Tian Chen and Richard Simman (Toledo, USA - Wounds).
The mouth’s curative superpowers - Nature.com
Article by Natalie Healey. Wounds in the mouth heal faster than in skin — and without scarring. Could unravelling the mechanisms that drive regeneration in the oral cavity lead to better wound therapies?
Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats - Dovepress.com
Article by Haile Tazeze, Solomon Mequanente, Dereje Nigussie, Belete Legesse, Eyasu Makonnen and Teklie Mengie (Ethiopia - Journal of Inflammation Research).
Data obtained from this study collectively indicated that Aloe trigonantha is a potential wound-healing and anti-inflammatory agent in rat models of wound and inflammation which provides evidence for the traditional claim.
11,12 Epoxyeicosatrienoic Acid Rescues Deteriorated Wound Healing in Diabetes - Mdpi.com
Article by Katharina Sommer, Heike Jakob, Caroline Reiche, Dirk Henrich, Jasmina Sterz, Johannes Frank, Ingo Marzi and Anna Lena Sander (Germany - IJMS).
11,12 EET improve deteriorated wound healing in diabetes by enhancing neoangiogenesis, especially in the early phase of wound healing. Furthermore, they contribute to the dissolution of the initial inflammatory reaction, allowing the crucial transition from the inflammatory to proliferative phase in wound healing.
Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing - Mdpi.com
Article by Lin-Cui Da, Yi-Zhou Huang, Hui-Qi Xie, Bei-Hong Zheng, Yong-Can Huang and Sheng-Rong Du (China - Pharmaceutics).
With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced extracellular matrix-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.
Immediate application of negative pressure wound therapy following lower extremity flap reconstruction in sixteen patients - Nature.com
Article by Chun-Yu Chen, Shyh-Ming Kuo, Yih-Wen Tarng and Kai-Cheng Lin (Taiwan - Scientific Reports).
The use of immediate incisional NPWT is an alternative for wound care following flap coverage. The U-shaped design allows easy flap observation and temperature check. Furthermore, this method eliminates any concerns of vascular pedicle compression under negative pressure.
Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition - Plos.org
Article by Karina Gomes Moreira, Thais Paulino do Prado, Natália Ferreira Mendes, Renan de Medeiros Bezerra, Carlos Poblete Jara, Maria Helena Melo Lima and Eliana Pereira de Araujo.
Piperonylic acid is a readily available and low-cost product that could be a viable therapeutic option to improve wound healing by modulating important genes involved in this process without having any apparent unwanted effects.
Personalized and Programable Microneedle Dressing for Promoting Wound Healing - PubMed
Abstract by Yuqiu Wang, Huihui Lu, Maoze Guo, Jianlin Chu, Bingbing Gao and Bingfang He (Nanjing, China - Adv Healthc Mater.).
Net Health Research into Machine Learning for Wound Care Highlighted in Leading Journal - Healthcaredive.com
Article in Advances in Wound Care shows how tech can help pinpoint individual patient risk factors that delay wound healing, giving clinicians better insights into treatments and interventions.
Platelets in Wound Healing: What Happens in Space? - Frontiersin.org
Article by Laura Locatelli, Alessandra Colciago, Sara Castiglioni and Jeanette A. Maier (Milan, Italy - Front. Bioeng. Biotechnol.).
The authors provide an overview about events linking platelets to the impairment of wound healing in space, also considering, besides weightlessness, exposure to radiation and psychological stress. In the end they discuss the possibility of utilizing platelet rich plasma as a tool to treat skin injuries eventually occurring during space missions.
Negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention (SWHSI-2 trial): study protocol for a pragmatic, multicentre, cross surgical specialty, randomised controlled trial - Biomedcentral.com
Article by Ian Chetter, Catherine Arundel, Belen Corbacho Martin, Catherine Hewitt, Caroline Fairhurst, Kalpita Joshi, Andrew Mott, Sara Rodgers, Pedro Saramago Goncalves, David Torgerson, Jacqueline Wilkinson, Jane Blazeby, Rhiannon Macefield, Stephen Dixon, Eileen Henderson, Angela Oswald, Jo Dumville, Matthew Lee, Thomas Pinkney, Nikki Stubbs and Lyn Wilson (York, UK - Trials).
Given the increasing use of NPWT, despite limited high-quality supporting evidence, the SWHSI-2 Trial will provide robust evidence on the clinical and cost-effectiveness of NPWT in the management of SWHSI.
Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients - Hindawi.com
Article by Jian Cai, Duyin Jiang and Wei Zang (Shandong, China - Evidence-Based Complementary and Alternative Medicine).
The authors' results showed that collagen sponge combined with autologous skin graft was effective in the treatment of deep burn patients, and it was worth popularizing. Deep III-IV degree burns, wound infection, and hospital stay >3 months are all risk factors affecting the postoperative curative effect of patients.
Successful application of extracorporeal circulation compression perfusion in the treatment of diabetic foot: a retrospective cross-sectional study - PubMed
Abstract by Lei Gao, Tianbo Li, Shuo Wang and Jiangning Wang (Beijing, China - J Int Med Res.).
Biocompatible Nanosized Quercetin-PVA Xerogel Films for Wound Dressing - Sciencedirect.com
Abstract by Xiaozhou Li, Xuxuan Yang, Zicheng Wang, Yanxiang Liu, Jiaxiang Guo, Yu Zhu, Jiaxing Shao, Jiage Li, Lin Wang and Ke Wang (China - Colloids and Surfaces B: Biointerfaces).
Preparation of W/O Hypaphorine-Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block - Mdpi.com
Article by Mengting Qi, Xuerui Zhu, Xiaoyi Yu, Min Ai, Weiwei Cai, Bin Du, Bao Hou and Liying Qiu (Jiangsu, China - Nanomaterials).
The authors' results indicate that HYP-NPS has a good application prospect in the treatment of chronic wounds.
Using Advanced Technologies to Prevent Surgical Site Infections - Woundsource.com
It was reported in 2014 that approximately 14 million operations were performed in the United States. The health care–associated infection prevalence survey conducted by the Centers for Disease Control and Prevention found an estimated 110,800 surgical site infections (SSIs) associated with inpatient surgical procedures in 2015.
Lower Extremity Wounds: Is It Venous, Arterial, Neuropathic, or a Combination? - Woundsource.com
Article by Holly Hovan. Lower extremity wounds manifest in a multitude of ways, and it can be challenging to differentiate among arterial, venous, and neuropathic wounds. With careful assessment, however, wound care professionals can make these crucial distinctions.
Development and Testing of an Algorithm to Prevent Medical Device-Related Pressure Injuries - PubMed
Abstract by Yeong-Mi Seong, Hyejin Lee and Ji Min Seo (Yangsan, South Korea - Inquiry).
Maggot Debridement Therapy for Chronic Leg and Foot Ulcers: A Review of Randomized Controlled Trials - PubMed
Abstract by Kevin Syam, Shaheer A Joiya, Sumayyah Khan and P Nithin Unnikrishnan (Oswestry, UK - Adv Skin Wound Care).
In Vitro Gingival Wound Healing Activity of Extracts from Reynoutria japonica Houtt Rhizomes - Mdpi.com
Article by Izabela Nawrot-Hadzik, Adam Matkowski, Artur Pitułaj, Barbara Sterczała, Cyprian Olchowy, Anna Szewczyk and Anna Choromańska (Wroclaw, Poland - Pharmaceutics).
The 25% EtOH extract from R. japonica rhizomes appears to be a promising gingival wound healing agent worthy of animal and clinical trials.
Wound Healing After Endovascular Therapy in Chronic Limb Threatening Ischaemia - Sciencedirect.com
Abstract by Yong-Joon Lee, Chul-Min Ahn, Young-Guk Ko, Kwang H. Park, Jin W. Lee, Seung-Jun Lee, Sung-Jin Hong, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong and Yangsoo Jang (Seoul, South Korea - European Journal of Vascular and Endovascular Surgery).
Hydrogel vectors based on peptide and peptide-like substances: For treating bacterial infections and promoting wound healing - Sciencedirect.com
Abstract by Taimin Xu, Yongchang Tian, Rong Zhang, Bing Yu, Hailin Cong and Youqing Shen (China - Applied Materials Today).
Novel placement of an esophageal wound vacuum for a persistent anastomotic leak - Sciencedirect.com
Abstract by Jonathan Wong, Dave Lal, Jack Schneider, Ali Mejaddam, Michael Manfredi and Diana Lerner (USA - Endoscopy).
Development and In Vitro Evaluation of Biocompatible PLA-Based Trilayer Nanofibrous Membranes for the Delivery of Nanoceria: A Novel Approach for Diabetic Wound Healing - Mdpi.com
Article by Mohamed Ahmed Mohamady Hussein, Sena Su, Songul Ulag, Agata Woźniak, Mariusz Grinholc, Gökce Erdemir, Serap Erdem Kuruca, Oguzhan Gunduz, Mamoun Muhammed, Ibrahim M. El-Sherbiny and Mosaad Megahed (Germany, Egypt, Turkey, Poland - Polymers).
The obtained results suggest that designated trilayer nanofibrous membranes would offer a specific approach for the treatment of diabetic wounds through an effective controlled release of nCeO2.
NUS scientists develop a smart bandage to monitor chronic wounds - News-medical.net
A research team led by Professor Lim Chwee Teck from the National University of Singapore's (NUS) Department of Biomedical Engineering and Institute for Health Innovation & Technology (iHealthtech), in collaboration with clinical partners from Singapore General Hospital, has developed a smart wearable sensor that can conduct real-time, point-of-care assessment of chronic wounds wirelessly via an app.
Effect of Earthworm on Wound Healing: A Systematic Review and Meta-Analysis - Frontiersin.org
Article by Dong Wang, Zhen Ruan, Rongchao Zhang, Xuejing Wang, Ruihui Wang and Zhishu Tang (Xianyang, China - Front. Pharmacol.)
The results of this meta-analysis demonstrated the efficacy of earthworm extracts (EE) on wound healing process. As a corollary, EE can be a useful natural product for wound healing drug development.
Closed-Incision Negative Pressure Therapy Decreases Wound Morbidity in Open Abdominal Wall Reconstruction With Concomitant Panniculectomy - PubMed
Abstract by Sullivan A Ayuso, Sharbel A Elhage, Leslie M Okorji, Kent W Kercher, Paul D Colavita, B Todd Heniford and Vedra A Augenstein (Charlotte, USA - Ann Plast Surg.).
Zeolitic imidazolate framework-67 accelerates infected diabetic chronic wound healing - Sciencedirect.com
Abstract by Jinghuang Chen, Xingfu Baoc TianMeng, Jian Sun and Xiurong Yang (China - Chemical Engineering Journal).
Insight into Factors Influencing Wound Healing Using Phosphorylated Cellulose-Filled-Chitosan Nanocomposite Films - Mdpi.com
Article by Marta Kędzierska, Sara Blilid, Katarzyna Miłowska, Joanna Kołodziejczyk-Czepas, Nadia Katir, Mohammed Lahcini, Abdelkrim El Kadib and Maria Bryszewska (Poland, Morocco - IJMS).
These biocompatible films showed no genotoxicity, and very importantly for wound healing, most of them significantly accelerated migration of both fibroblasts and keratinocytes.
Hyaluronic acid sustains platelet stability with prolonged growth factor release and accelerates wound healing by enhancing proliferation and collagen deposition in diabetic mice - Sciencedirect.com
Abstract by Sneha S. Rao, Ashwini Prabhu, Jagadish Kudkuli, Suprith Surya and P. D. Rekha (Mangalore, India - Journal of Drug Delivery Science and Technology).
Smart dressings for wound monitoring and treatment: new-type skin bioelectronic systems applicated in wound repair - Authorea.com
Article by Yu-Fan Zhong, Yong Wang, Yan-Yan Hu, Xiao-Feng Wang, Fa-Wei Xu, Yan-Qi Liu, Qing-Qing Fang, Wan-Yi Zhao, Ting-Wen Kuo, Ya-Nan Xue and Wei-Qiang Tan (Hangzhou, China).
In this review, wound healing-related indexes in the wound microenvironment are discussed, applications of various smart dressings with functions of monitoring or/and treatment are summarized.
Imaging Techniques Used for Wound Healing Assessment: A Systematic Review Part 1 Chronic Wounds - Mdpi.com
Article by Poh Tan, Joanne Lim and Naiem Moiemen (UK - EBJ).
This review collectively evaluates objective, reliable, quantitative, and innovative tools to assess wound healing objectively. The most superior wound measuring device was two dimensional.
The Role of Negative-Pressure Wound Therapy in Patients with Fracture-Related Infection: A Systematic Review and Critical Appraisal - Hindawi.com
Article by Susan Haidari, Frank F. A. IJpma, Willem-Jan Metsemakers, Wies Maarse, H. Charles Vogely, Alex J. Ramsden, Martin A. McNally and Geertje A. M. Govaert (The Netherlands, Belgium, UK - BioMed Research International).
This review provides an assessment of current literature on the role of NPWT in the management of soft tissue defects in patients with FRI. Due to the lack of uniformity in included studies, conclusions should be drawn with caution. Currently, there is no clear scientific evidence to support the use of NPWT as definitive treatment in FRI.
Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings - Mdpi.com
Article by Eyal Melamed, Alexei Rovitsky, Tohar Roth, Lior Assa and Gadi Borkow (Israel - Medicina).
The results of this study, showing a statistically significant influence of copper oxide microparticles on wound healing of hard-to-heal wounds in diabetic patients, strongly supports the notion that copper oxide-impregnated dressings enhance wound healing directly.
A Prospective Randomized Pilot Study Evaluating the Scar Outcome after Gluteal Dermis Fat Graft with and without Kinesiotaping - Researchsquare.com
Article by Annemarie Klingenstein, Aylin Garip-Kuebler, Daniel R Muth and Christoph Hintschich (Munich, Germany).
No functionally impairing or painful scar developed. No adverse effects occurred after kinesiotaping. Gluteal scars shortened significantly over time and were significantly paler in the case group. Kinesiotaping could prevent hypertrophic scarring or keloid formation.
Synthesis and wound healing performance of new water-soluble chitosan derivatives - Wiley.com
Abstract by Lubna Shahzadi, Arshad Jamal, Pegah Hajivand, Nasir Mahmood, Aqif Anwar Chaudhry, Ihtesham ur Rehman and Muhammad Yar (J. Applied Polymer Science).
Early ABI Testing May Decrease Risk of Amputation for Patients with Lower Extremity Ulcers - PubMed
Abstract by Angela Aguirre, Kritika Sharma, Aman Arora and Misty D Humphries (Sacramento, USA - Ann Vasc Surg.).
Cellular Signalling and Photobiomodulation in Chronic Wound Repair - Mdpi.com
Article by Thobekile S. Leyane,Sandy W. Jere and Nicolette N. Houreld (Johannesburg, South Africa - IMJS).
This review highlights the significant role of photobiomodulation in the activation of several cell signalling pathways involved in wound healing.
Curcumin upregulates transforming growth factor-β1, its receptors, and vascular endothelial growth factor expressions in an in vitro human gingival fibroblast wound healing model - Biomedcentral.com
Article by Auspreeya Rujirachotiwat and Supaporn Suttamanatwong (Bangkok, Thailand - BMC Oral Health).
The authors' findings support the development of curcumin as a therapeutic agent for gingival ulcers.
Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing - Sciencedirect.com
Abstract by Bing-De Zheng, Jing Ye, Yu-Cheng Yang, Ya-Yan Huang and Mei-Tian Xiao (Xiamen, China - Carbohydrate Polymers).
Modified negative-pressure wound therapy for linear blister formation prevention around foam dressings: technical note and case series - PubMed
Abstract by Congming Zhang, Qian Wang, Zhimeng Wang, Qiang Huang, Chenchen Zhang, Ning Duan, Hua Lin, Teng Ma, Kun Zhang, Hanzhong Xue and Zhong Li (Xi'an, China - J Orthop Surg Res.).
S100A8/A9 Enhances Immunomodulatory and Tissue-Repairing Properties of Human Amniotic Mesenchymal Stem Cells in Myocardial Ischemia-Reperfusion Injury - Mdpi.com
Article by Tzu-Jou Chen, Yen-Ting Yeh, Fu-Shiang Peng, Ai-Hsien Li and Shinn-Chih Wu (Taiwan - IJMS).
This study demonstrated intravenous administration of the conditioned medium of S100A8/A9-pretreated hAMSCs improved left ventricular function and decreased myocardial fibrosis after I/R injury. S100A8/A9 pretreatment enhanced the paracrine immunomodulatory and tissue-repairing properties of hAMSCs by changing relevant gene expressions.
Dissolved oxygen technologies as a novel strategy for non-healing wounds: A critical review - Wiley.com
Abstract by Dimitrios P. Ntentakis, Anastasia Maria Ntentaki, Eleni Delavogia, Loukas Kalomoiris, Danae Venieri, Nikolaos Arkadopoulos and Nicolas Kalogerakis (Greece - Wound Repair and Regeneration).
Results of Ankle and Hind foot arthrodesis in Diabetic Charcot Neuroarthropathy - A retrospective analysis of 44 patients - Sciencedirect.com
Abstract by Balvinder Rana and Sandeep Patel (India - Journal of Clinical Orthopaedics and Trauma).
Predicting Chronic Wound Healing Time Using Machine Learning - PubMed
Abstract by Matthew Berezo, Joshua Budman, Daniel Deutscher, Cathy Thomas Hess, Kyle Smith and Deanna Hayes (Pittsburgh, USA - Adv Wound Care (New Rochelle)).
The Unexplored Wound Healing Activity of Urtica dioica L. Extract: An In Vitro and In Vivo Study - Mdpi.com
Article by Athanasia I. Kasouni, Theodoros G. Chatzimitakos, Constantine D. Stalikas, Theoni Trangas, Alexandra Papoudou-Bai and Anastassios N. Troganis (Ioannina, Greece - Molecules).
Histopathological examination of the wound tissue revealed, among other findings, that inflammation was significantly reduced compared to the control. Urtica dioica L. extract application results in faster wound healing, making the extract ideal for wound healing applications and a novel drug candidate for wound healing.
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds - Nature.com
Article by Viveka Kalidasan, Xin Yang, Ze Xiong, Renee R. Li, Haicheng Yao, Hareesh Godaba, Sybil Obuobi, Priti Singh, Xin Guan, Xi Tian, Selman A. Kurt, Zhipeng Li, Devika Mukherjee, Ravisankar Rajarethinam, Choon Seng Chong, Jiong-Wei Wang, Pui Lai Rachel Ee, Weiqiang Loke, Benjamin C. K. Tee, Jianyong Ouyang, Christopher J. Charles and John S. Ho (Singapore, New Zealand - Nature Biomedical Engineering).
The authors show in live pigs that the sutures can monitor wound integrity, gastric leakage and tissue micromotions, and in rodents that the healing outcomes are equivalent to those of medical-grade sutures. Battery-free wirelessly operated bioelectronic sutures may facilitate post-surgical monitoring in a wide range of interventions.
Biocompatible therapeutic albumin/genipin bioglue for postoperative wound adhesion and residual tumor ablation - Sciencedirect.com
Article by Yaqiong Wang, Jingjing Guod, Bingjie Li, Dong Li, Zhaowei Meng and Shao-KaiSun (Tianjin, China - Biomaterials).
A unique characteristic allows BSA-GP a therapeutic adhesive for postoperative wound adhesion and photothermal elimination of residual tumors under laser irradiation. Moreover, its easy injectability and impressive photothermal efficacy also make it feasible for in situ tumor photothermal ablation.
Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing - Beilstein-journals.org
Article by Luke O. Jones, Leah Williams, Tasmin Boam, Martin Kalmet, Chidubem Oguike and Fiona L. Hatton (Loughborough, UK - Journal of Organic Chemistry).
Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.
Cutaneous Regeneration Mechanism of β-Sheet Silk Fibroin in a Rat Burn Wound Healing Model - Mdpi.com
Article by Kai-Chieh Chou, Chun-Ting Chen, Juin-Hong Cherng, Ming-Chia Li, Chia-Cheng Wen, Sheng-I Hu and Yi-Wen Wang (Taiwan - Polymers).
The authors demonstrated that β-sheet SF facilitates tissue regeneration by modulating cell adhesion molecules in dermal fibroblasts. LSFD could find clinical application for burn wound regeneration.
The infection characteristics and autophagy defect of dermal macrophages in STZ-induced diabetic rats skin wound Staphylococcus aureus infection model - Wiley.com
Article by Xiaoying Xie, Rihui Zhong, Ling Luo, Xianghua Lin, Lisi Huang, Songyin Huang, Lijia Ni, Baiji Chen, Rui Shen, Li Yan and Chaohui Duan (Immunity, Inflamation and Disease).
The authors' results first provided convincing evidence that autophagy of macrophages was dysfunctional in diabetes, especially after being infected by S. aureus, which weakens the intracellular killing of S. aureus, potentially worsens the infections, and accelerates the infection spread in the diabetic rat model.
The effects of medicinal herbs and marine natural products on wound healing of cutaneous leishmaniasis: A systematic review - PubMed
Abstract by Elahe Tajbakhsh, Ali Khamesipour, Seyed Reza Hosseini, Neda Kosari, Shima Shantiae and Faham Khamesipour (Iran - Microb Pathog.).
Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities - PubMed
Abstract by Muhammad Umar Aslam Khan, Sajjad Haider, Mohsin Ali Raza, Saqlain A Shah, Saiful Izwan Abd Razak, Mohammad Rafiq Abdul Kadir, Fazli Subhan and Adnan Haider (Malaysia, Pakistan, Saudi Arabia - Int J Biol Macromol.).
Novel scaffold based graphene oxide doped electrospun iota carrageenan/polyvinyl alcohol for wound healing and pathogen reduction: in-vitro and in-vivo study - Nature.com
Article by Marwa H. Gouda, Safaa M. Ali, Sarah Samir Othman, Samia A. Abd Al-Aziz, Marwa M. Abu-Serie, Noha A. Elsokary and Noha A. Elessawy (Alexandria, Egypt - Scientific Reports).
Whereas it can be used as an effective antimicrobial agent in wound healing, however, histopathological findings confirmed that the electrospun nanofiber scaffold named (MNS) caused re-epithelialization and the presence of yeast induced hair follicles growth and subsequently it may be used to hide formed head wound scar.
A Beginner’s Introduction to Skin Stem Cells and Wound Healing - Mdpi.com
Article by Daniel Díaz-García, Alžbeta Filipová, Idalia Garza-Veloz and Margarita L. Martinez-Fierro (Czech Republic, Mexico - IJMS).
Given its extensive and broad nature, this review supplies newcomers with an introduction to SSCs, wound healing, and therapeutic strategies for skin regeneration, thus familiarizing the reader with the subject in preparation for future in depth reading.
Surgical Site Infection: What Causes the Infection? - Woundsource.com
Although advances in surgical techniques and operating room technologies have made many surgical procedures more successful and have led to easier recovery for many patients, surgical site infections (SSIs) remain a clinical problem. These infections are associated with increased morbidity, mortality, and health care costs.
Preparation of NIR-responsive, ROS-generating and antibacterial black phosphorus quantum dots for promoting the MRSA-infected wound healing in diabetic rats - PubMed
Abstract by Shuocheng Huang, Shibo Xu, Yanan Hu, Xingjun Zhao, Linna Chang, Zhenhua Chen and Xifan Mei (Liaoning, China - Acta Biomater.).
A filled chocolates technique to seal negative-pressure wound therapy around external fixation devices: a randomized controlled trial - PubMed
Abstract by Wei Fan, Fushan Hou, Kun Xi, Chen Hao, Xiangdong Lu and Bin Zhao (China - J Orthop Surg Res.).
Wound Healing-Promoting and Melanogenesis-Inhibiting Activities of Angelica polymorpha Maxim. Flower Absolute In Vitro and Its Chemical Composition - Mdpi.com
Article by Su-Yeon Lee, Kyung-Jong Won, Do-Yoon Kim, Mi-Jung Kim, Yu-Rim Won, Nan-Young Kim and Hwan-Myung Lee (Korea - Molecules).
The authors' findings demonstrate that APMFAb has beneficial effects on skin wound healing by promoting the proliferation, migration, and collagen synthesis of keratinocytes and on skin whitening by inhibiting melanin synthesis in melanoma cells.
Effects of dipotassium glycyrrhizinate on wound healing - Scielo.br
Article by Camila dos Santos Leite, Oscar César Pires, Danielle Gatti Tenis, Jussara Vaz Nascimento Ziegler, Denise Gonçalves Priolli and Thalita Rocha (Brazil - Acta Cirúrgica Brasileira).
Dipotassium glycyrrhizinate induced wound healing/skin regeneration, with collagen I, being more effective in the first 14 days after injury.
The Pathophysiology of Skin Failure vs. Pressure Injury: Conditions That Cause Integument Destruction and Their Associated Implications - PubMed
Abstract by Michael Bain, Junko Hara and Marissa J Carter (USA - Wounds).
Comparison of the Therapeutic Effects of Native and Anionic Nanofibrillar Cellulose Hydrogels for Full-Thickness Skin Wound Healing - Mdpi.com
Article by Raili Koivuniemi, Qian Xu, Jasmi Snirvi, Irene Lara-Sáez, Arto Merivaara, Kari Luukko, Markus Nuopponen, Wenxin Wang and Marjo Yliperttula (Finland, Ireland - Micro).
The data show here for the first time the therapeutic performance of native and anionic NFC hydrogel in a wound mimicking human wound healing mechanisms. The mechanical properties of native and anionic NFC hydrogels such as the capability to modify material stiffness may also prove to be valuable in the management of wounds in the future.
Investigation of Angiogenesis and Wound Healing Potential Mechanisms of Zinc Oxide Nanorods - Frontiersin.org
Article by Amr Hassan,Ahmed I. Abd El Maksoud, Dalia Elebeedy, Mohammad A. Zoair and Emadeldin R. Matar (Egypt - Front. Pharmacol.).
This study demonstrated that angiogenesis and wound healing processes depend on pro-angiogenic factors as VEGF expression due to ZnO nanorods' exiting. Angiogenesis induced via zinc oxide nanorods may develop sophisticated materials to apply in the wound healing field.
Antimicrobial and Immunomodulatory Activity of Herb Extracts Used in Burn Wound Healing: “San Huang Powder” - Hindawi.com
Article by Jia-Ru Wu, Yu-Chu Lu, Sung-Jen Hung, Jung-Hsing Lin, Kai-Chih Chang, Jhong-Kuei Chen, Wan-Ting Tsai, Tsung-Jung Ho and Hao-Ping Chen (Hualien, Taiwan - Evidence-Based Complementary and Alternative Medicine).
The authors' results not only provide a basis to understand why “San Huang Powder” has been used to clinically treat wounds without sterilization directly since ancient times but also show the advantages of using multiple herb materials simultaneously on wound sites to prevent infection during treatment.
Role of Neurons and Glia Cells in Wound Healing as a Novel Perspective Considering Platelet as a Conventional Player - Springer.com
Abstract by Samir K. Beura, Abhishek R. Panigrahi, Pooja Yadav, Siwani Agrawal and Sunil K. Singh (Molecular Neurobiology).
Surgical Wound Complications - Woundsource.com
Despite modern precautions and protocols in place, surgical site infection (SSI) continues to be a risk. SSIs are the most common and costly of all hospital-acquired infections, with an estimated annual cost of $3.5 to $10 billion in the United States.
Extracellular matrix and cellular senescence in venous leg ulcers - Nature.com
Article by Debbie X. E. Lim, Toby Richards, Muholan Kanapathy, Thankiah Sudhaharan, Graham D. Wright, Anthony R. J. Phillips and David L. Becker (Singapore, Australia, UK, New Zealand - Scientific Reports).
The authors' data support the use of collagen imaging in cutaneous wound assessment for a faster and non-invasive method to predict cellular senescence and determining wound trajectory of healing.
Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review - Mdpi.com
Article by Fa-Wei Xu, Ying-Li Lv, Yu-Fan Zhong, Ya-Nan Xue, Yong Wang, Li-Yun Zhang, Xian Hu and Wei-Qiang Tan (Hangzhou, China - Molecules).
This review expatiates on the rationale of using epigallocatechin gallate (EGCG) to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.
Wounds with Heavy or Purulent Drainage - Woundsource.com
A wound with heavy or purulent drainage is a localized defect or excavation of the skin or underlying soft tissue that produces large amounts of serous, sanguineous, serosanguineous or purulent discharge. Purulent wound drainage is thick with a yellow, green or brown color, with a pungent, strong, foul, fecal or musty odor. Purulent drainage is a sign of an unhealthy wound and demands treatment.
Intertriginous Dermatitis: Risk Factors, Diagnosis, Prevention, and Treatment - Woundsource.com
Article by Holly Hovan. Intertriginous dermatitis (ITD), also referred to as intertrigo, is an inflammatory condition that affects opposing skin surfaces and can occur anywhere on the body where two surfaces are in contact.
Advances in Skin Wound and Scar Repair by Polymer Scaffolds - Mdpi.com
Article by Shuiqing Zhou, Qiusheng Wang, Ao Huang, Hongdou Fan, Shuqin Yan and Qiang Zhang (Wuhan, China - Molecules).
Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.
Wound healing potential of Punica granatum linn fruit peel - Xisdxjxsu.asia
Abstract by Prerana Nimmy Chacko and Zueena Shetty (Mangalore, India - Journal of Xi'an Shiyou University).
Effect of negative pressure wound therapy on wound complications in obese women after caesarean birth: A systematic review and meta-analysis - PubMed
Abstract by Brigid M Gillespie, Lukman Thalib, David Ellwood, Evelyn Kang, Kaasam Mahomed, Sailesh Kumar and Wendy Chaboyer (Australia - BJOG).
Electrospun Medicated Nanofibers for Wound Healing: Review - Mdpi.com
Article by Xinkuan Liu, Haixia Xu, Mingxin Zhang and Deng-Guang Yu (Shanghai, China - Membranes).
This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology.
Plant-based mucilage with healing and anti-inflammatory actions for topical application: A review - Sciencedirect.com
Article by Josemar Gonçalves de Oliveira Filho, Michelle Monteiro Lira, Tainara Leal de Sousa, Stéphani Borges Campos, Ailton Cesar Lemes and Mariana Buranelo Ege (Brazil, Food Hydrocolloids for Health).
This review highlights plant-based mucilage that may or may not form a film (used as a dressing or a cream) and can be used for topical application due to demonstrated anti-inflammatory or healing properties.
A bilayered skin substitute developed using eggshell membrane crosslinked gelatin-chitosan cryogel - Rsc.org
Abstract by Rituparna Saha, Shivali Patkar, Drishti Maniar, Mamatha M Pillai and Prakriti Tayalia (Biomaterial Science).
An Overview of Present-Day Negative Pressure Wound Therapy – Part Two - Hmpgloballearningnetwork.com
In part two of this three-part NPWT educational series offered in partnership with ExtriCARE USA, we will explore the current state of NPWT in the industry, how that is evolving, and what challenges are presented as the treatment advances to the next level.
Diabetic Wound-Healing Science - Mdpi.com
Article by Jamie L. Burgess, W. Austin Wyant, Beatriz Abdo Abujamra, Robert S. Kirsner and Ivan Jozic (Miami, USA - Medicina).
Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds.
Novel insights into negative pressure wound healing from an in situ porcine perspective - PubMed
Abstract by Jacob G Hodge, Ashley L Pistorio, Christopher A Neal, Hongyan Dai, Jennifer G Nelson-Brantley, Molly E Steed, Richard A Korentager, David S Zamierowski and Adam J Mellott (USA - Wound Repair Regen.).
Honey in wound healing: An updated review - Degruyter.com
Article by Hanaa Tashkandi (Jeddah, Saudi-Arabia - Open Life Sciences).
The aim of this review is to summarize recent studies on the wound healing properties of honey.
Transcriptomic Time Series Analysis in Wound Healing: Challenges and Perspectives on Data Interpretation - Researchsquare.com
Article by Ksenia Zlobina, Eric Malekos, Han Chen and Marcella Gomez (Santa Cruz, USA).
A list of genes that may be used for transcriptomics-based wound healing stage detection is provided. In addition, the authors suggest experimental approaches that could help researchers to extract more meaningful results.
Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing - Iop.org
Abstract by Reena Badhwar, Bharti Mangla, Yub Raj Neupane, Kushagra Khanna and Harvinder Popli (India, Singapore - Nanotechnology).
Remote Diabetic Foot Temperature Monitoring for Early Detection of Diabetic Foot Ulcers: A Cost-Effectiveness Analysis - Dovepress.com
Article by Elizabeth Brooks, Megan Burns, Ran Ma, Henk Jan Scholten and Shawn Becker (USA - ClinicoEconomics and Outcomes Research).
RFTM is a cost-effective addition to standard of care (SoC) in patients with diabetic neuropathy at a moderate-to-high risk of DFU and subsequent amputation. Further, reduction in DFU and associated complications may result in improvements in the patient’s quality of life and mental health.
Diagnostic Key Points and Surgical Management of Necrotizing Fasciitis: A Retrospective Study - PubMed
Abstract by Xiaojing Ge, Yute Sun, Jing Lin, Fang Zhou, Gang Yao, Binlin Luo and Xin Su (Nanjing, China - Int J Low Extrem Wounds).
Faster healing of wounds can decrease pain and suffering and save lives - Wwnytv.com
Researchers at the College of Medicine at the University of Central Florida (UCF) in Orlando have discovered a new technology to accelerate wound healing. Their research is published in the Life Cell Biology and Tissue Engineering Journal. The UCF lab's research focus is to develop stem cell therapies for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, wound healing and ALS.
Proteomics changes after negative pressure wound therapy in diabetic foot ulcers - PubMed
Abstract by Zeguo Jia, Lei Liu, Shiqian Zhang, Xiaotong Zhao, Li Luo, Yizhong Tang, Bing Shen and Mingwei Chen (Hefei, China - Mol Med Rep.).
Effects of Simultaneous versus Staged VAC Placement in the Treatment of Deep Neck Multiple-Space Infections at a Tertiary Hospital Over a Four-Year Period in China - Dovepress.com
Article by Weijiao Liu, Wei Gu, Xiaofeng Jin and Jian Wang (Beijing, China - Infection and Drug Resistance).
Simultaneous VAC placement during incision and drainage may shorten the wound healing time, hospitalization duration, and disease course and may reduce the number of debridement procedures.
Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications - Dovepress.com
Article by Evi Sulastri, Muhammad Sulaiman Zubair, Ronny Lesmana, Ahmed Fouad Abdelwahab Mohammed and Nasrul Wathoni (Indonesia, Egypt - Drug Design, Development and Therapy).
The swelling behavior and WVTR of these films are great and could have potential as a wound dressing biomaterial, supported by their antimicrobial and antioxidant properties.
The Role of Nutritional Interventions in Wound Care - Dermatologytimes.com
Article by Linda Stocum.
The nutritional intervention and its role in wound care has been a controversial topic, according to authors of a review recently published in the Plastic and Reconstructive Surgery journal.
This is the first literature review of mineral and vitamin wound intervention using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines by wound type, according to the review’s authors.
Development and Testing of the Foot Care Scale for Older Japanese Diabetic Patients - Sagepub.com
Abstract by Sayuri Sable-Morita, Yuki Arai, Sanae Takanashi, Keita Aimoto, Mika Okura, Takahisa Tanikawa, Keisuke Maeda, Haruhiko Tokuda and Hidenori Arai (Japan - The International Journal of Lower Extremity Wounds).
Sticking to What Matters: A Matched Comparative Study of Fibrin Glue and Mechanical Fixation for Split-Thickness Skin Grafts in the Lower Extremity - Sagepub.com
Abstract by Sammy Othman, Charles A. Messa, Omar Elfanagely, Bradford Bormann, Joseph A. Mellia, Robyn B. Broach, Stephen J. Kovach and John P. Fischer (Philadelphia, USA - The International Journal of Lower Extremity Wounds).
Free Vascularized Fibula Flap for Septic Bone Defects of the Lower Limb - Sagepub.com
Abstract by Iván Copete González, Nieves Vanaclocha, Alberto Sánchez-García, Alessandro Thione and Alberto Pérez-García (Valencia, Spain - The International Journal of Lower Extremity Wounds).
Alternative Approaches for the Management of Diabetic Foot Ulcers - Frontiersin.org
Article by Cassandra Pouget, Catherine Dunyach-Remy, Alix Pantel, Adeline Boutet-Dubois, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne and Paul Loubet (Nimes, France - Front. Microbiol.).
The authors discuss current knowledge on biofilm in DFU and they focus on some new alternative solutions for the management of these wounds, such as antibiofilm approaches that could prevent the establishment of microbial biofilms and wound chronicity.
Mesenchymal Stem Cell Secretome for Dermatology Application: A Review - Dovepress.com
Article by Restu Harisma Damayanti, Taofik Rusdiana and Nasrul Wathoni (Sumedang, Indonesia - Clinical, Cosmetic and Investigational Dermatology).
Based on the results, it was concluded that secretome has a variety of useful activities to regenerate and repair tissue damage that have not been used on the skin, such as for wound healing, photoprotection, promotion of hair growth, psoriasis treatment, and other application as antimicrobial.
Effects of photobiomodulation on wound contraction in rats undergoing doxorubicin extravasation: a histomorphometric analysis - PubMed
Abstract by Karina Alexandra Batista da Silva Freitas, Noeme Sousa Rocha, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Hélio Langoni and Regina Célia Popim (Brazil - Rev Esc Enferm USP).
Modified negative pressure wound therapy as an adjunct to antibiotics in the treatment of orthopaedic infected metalwork - PubMed
Abstract by Selina Summers, Natasha Faye Daniels, Azeem Thahir and Matija Krkovic (Cambridge, UK - Eur J Orthop Surg Traumatol.).
Antibacterial and Therapeutic Potentials of the Capsicum annuum Extract against Infected Wound in a Rat Model with Its Mechanisms of Antibacterial Action - Hindawi.com
Article by Steve Endeguele Ekom, Jean-De-Dieu Tamokou and Victor Kuete (Dschang, Cameroon - BioMed Research International).
The findings of the study support the traditional use of the studied plant in the treatment of wounds and infectious diseases associated with the tested bacteria.
Edema - Woundsource.com
Edema, (alternate spelling: oedema) formerly referred to as dropsy or hydropsy, is the swelling of the body's tissues due to excess interstitial fluid retention. Edema can occur locally, often affecting the extremities (peripheral edema), or generally, affecting the entire body (anasarca).
Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing - Sciencedirect.com
Abstract by Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang and Jinping Zhou (Wuhan, China - Carbohydrate Polymers).
Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits - PubMed
Abstract by Nazira Fatima, Muhammad Saleem and Umar Shahbaz (China, Pakistan - Drug Res (Stuttg)).
Angiogenin and Copper Crossing in Wound Healing - Mdpi.com
Article by Lorena Maria Cucci, Cristina Satriano, Tiziano Marzo and Diego La Mendola (Italy, IJMS).
Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.
Evaluation of the cutaneous wound healing potential of tamanu oil in wounds induced in rats - Magonlinelibrary.com
Abstract by Sevil S Erdogan, Tugba F Gur, Neslihan K Terzi and Bilal Dogan (Journal of Wound Care).
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids - PubMed
Abstract by Rebecca R Miles, Parth H Amin, Miguel Barriera Diaz, Jagannath Misra, Erica Aukerman, Amitava Das, Nandini Ghosh, Tanner Guith, Michael D Knierman, Sashwati Roy, Dan F Spandau and Ronald C Wek (Indianapolis, USA - J Biol Chem.).
The Effect of Surgical Site Infections on Patient Reported Scar Cosmetic Outcomes in Dermatologic Surgery - PubMed
Abstract by R Hammarstrand and K Saleh (Lund, Sweden - Br J Dermatol.).
Malignant Transformation in Chronic Stage IV Sacral Pressure Ulcer: A Case of Marjolin Ulcer - PubMed
Abstract by Richard Simman, Fuad Abbas and Surendra P Singh (USA - Wounds).
Effect of Chlorhexidine Digluconate in Early Wound Healing of Human Gingival Tissues. A Histological, Immunohistochemical and Biomolecular Analysis - Mdpi.com
Article by Andrea Pilloni, Simona Ceccarelli, Daniela Bosco, Giulia Gerini, Cinzia Marchese, Lorenzo Marini and Mariana A. Rojas (Rome, Italy - Antibiotics).
This study assessed for the first time the in vivo effects of CHX on gingival tissue. The demonstration of a CHX-induced fibrotic transformation, leading to scar repair, supports the need for new post-surgical clinical protocols based on a strategic and personalized use of CHX.
Silk Fibroin: A Promising Tool for Wound Healing and Skin Regeneration - Hindawi.com
Article by M. Vidya and Senthilkumar Rajagopal (Bangalore, India - International Journal of Polymer Science).
This review gives a detailed insight into the structure, general properties, fibroin structure-properties relationship, and biomedical applications of silk fibroin.
Application Progress of Nano Silver Dressing in the Treatment of Diabetic Foot - Dovepress.com
Article by Huijing Lin, Alayi BoLatai and Na Wu (Shenyang, China - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy).
The current article discusses the pathogenesis of diabetic foot, diabetic foot dressing treatment, the application of nanotechnology in diabetic foot treatment, the efficacy evaluation of different dressings, and the practical prospects of adopting nanotechnology in the treatment of diabetic foot.
A platelet-derived hydrogel improves neo-vascularisation in full thickness wounds - PubMed
Abstract by Md M Rahman, N Garcia, Y S Loh, D C Marks, I Banakh, P Jagadeesan, N R Cameron, C Yung-Chih, M Costa, K Peter, H Cleland and S Akbarzadeh (Australia - Acta Biomater.).
The role of lipid-based signalling in wound healing and senescence - Sciencedirect.com
Article by Vera Pils, Lucia Terlecki-Zaniewicz, Markus Schosserer, Johannes Grillari and Ingo Lämmermann (Austria - Mechanisms of Ageing and Development).
The intriguing connection between cellular senescence, lipid-based signalling, and the process of wound healing and tissue regeneration prompts the authors to compile the current knowledge in this review and propose future directions for investigation.
Performance of Polydopamine Complex and Mechanisms in Wound Healing - Mdpi.com
Article by Dantong Zheng, Chongxing Huang, Xuhao Zhu, Haohe Huang and Chenglong Xu (Nanning, China - IJMS).
Unlike other dressings, PDA complexes can achieve both photothermal therapy and electro activity. In this paper, wound healing is divided into four stages: antibacterial, anti-inflammatory, cell adhesion and proliferation, and re-epithelialization. Photothermal therapy can improve the bacteriostatic rate and remove reactive oxygen species to inhibit inflammation.
Platelet-Released Growth Factors Induce Genes Involved in Extracellular Matrix Formation in Human Fibroblasts - Mdpi.com
Article by Andreas Bayer, Bernard Wijaya, Franziska Rademacher, Lena Möbus, Mark Preuß, Michael Singh, Mersedeh Tohidnezhad, Yusuke Kubo, Meno Rodewald, Peter Behrendt, Jan-Tobias Weitkamp, Regine Gläser and Jürgen Harder (Germany, IJMS).
The observed effects of PRGF on human fibroblasts may contribute to the underlying mechanisms that support the beneficial wound-healing effects of thrombocyte concentrate products.
Economic model to estimate cost of negative pressure wound therapy with instillation vs control therapies for hospitalised patients in the United States, Germany, and United Kingdom - PubMed
Abstract by Paul J Kim, Siobhan Lookess, Christine Bongards, Leah Passmore Griffin and Allen Gabriel (USA - Int Wound J.).
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