The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids - Jbc.org
Article by Rebecca R. Miles, Parth H. Amin, Miguel Barriera Diaz, Jagannath Misra, Erica Aukerman, Amitava Das, Nandini Ghosh, Tanner Guith, Michael D. Knierman, Sashwati Roy. Dan F. Spandau and Ronald C. Wek (Journal of Biological Chemistry).
The authors' results indicate that GCN2 is critical for appropriate induction of collective cell migration and plays a critical role in coordinating the re-epithelialization of cutaneous wounds.
Assessment of the structural and functional characteristics of human mesenchymal stem cells associated with a prolonged exposure of morphine - Nature.com
Article by Francesco Carano, Gabriella Teti, Alessandra Ruggeri, Francesca Chiarini, Arianna Giorgetti, Maria C. Mazzotti, Paolo Fais and Mirella Falconi (Bologna, Italy - Scientific Reports).
The authors' results showed a time dependent cell viability decline, and conditions compatible with a cellular senescent state. Ultrastructural and protein expression analysis were indicative of increased autophagy, suggesting a relation to a detoxification activity.
New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers - Mdpi.com
Article by Simona Serini and Gabriella Calviello (Rome, Italy - Foods).
The authors especially focused on recent studies investigating the mechanisms through which these compounds may act. Considerations on the optimal dietary doses are also reported, and, finally, possible future perspectives in this area are suggested.
Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration - PubMed
Abstract by Ehsan Zeimaran, Sara Pourshahrestani, Ali Fathi, Nasrul Anuar Bin Abd Razak, Nahrizul Adib Kadri, Amir Sheikhi and Francesco Baino (Malaysia, Italy - Acta Biomater.).
Enhancing esophageal repair with bioactive bilayer mesh containing FGF - Nature.com
Article by Ozkan Cesur, Tugba Endogan Tanir, Pinar Celepli, Fatma Ozarslan, Sema Hucumenoglu, Adnan Karaibrahimoglu and Nesrin Hasirci (Turkey - Scientific Reports).
It was proved that fibroblast growth factor (FGF) loaded bioactive bilayer mesh provided effective repair, reinforcement and tissue healing of esophageal defects.
What Are Eczema Scars? - Verywellhealth.com
Article by Aubrey Bailey. Eczema scars are part of a broader category of lasting marks that eczema can leave on your skin. These marks can be hyperpigmentation in healed spots or actual scars from scratching during a flare-up.
KLF4 Promotes Diabetic Chronic Wound Healing by Suppressing Th17 Cell Differentiation in an MDSC-Dependent Manner - PubMed
Abstract by Xiong Yang, Bryan J Mathis, Yu Huang, Wencheng Li and Ying Shi (China, Japan - J Diabetes Res.).
Diagnostic Accuracy of Point-of-Care Fluorescence Imaging for the Detection of Bacterial Burden in Wounds: Results from the 350-Patient Fluorescence Imaging Assessment and Guidance Trial - PubMed
Abstract by Lam Le, Marc Baer, Patrick Briggs, Neal Bullock, Windy Cole, Daniel DiMarco, Rachel Hamil, Khristina Harrell, Maria Kasper, Weili Li, Keyur Patel, Matthew Sabo, Kerry Thibodeaux and Thomas E Serena (USA - Adv Wound Care (New Rochelle)).
Mesoporous silica incorporated PCL/Curcumin nanofiber for wound healing application - PubMed
Abstract by Saranya Rathinavel, Purna Sai Korrapati, Periandavan Kalaiselvi and Sangeetha Dharmalingam (Chennai, India - Eur J Pharm Sci.).
Hydrogel Preparation Methods and Biomaterials for Wound Dressing - Mdpi.com
Article by Jingjing Su, Jiankang Li, Jiaheng Liang, Kun Zhang and Jingan Li (Zhengzhou, China - Life).
This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.
Nutrition and Healing Wounds - Thegeriatricdietitian.com
Article by Rachel Evans. Older adults have delicate skin which can be more susceptible to injury. Bruises and cuts happen to everyone, but the risk of these not healing properly and turning into more serious chronic wounds is increased as we age.
Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial - PubMed
Abstract by Bianca Campos Oliveira, Beatriz Guitton Renaud Baptista de Oliveira, Gabriela Deutsch, Fernanda Soares Pessanha and Selma Rodrigues de Castilho (Rio de Janeiro, Brazil - Wound Repair Regen.)
Effectiveness of the adipose stem cells in burn wound healing: literature review - PubMed
Abstract by Ahmad Oryan, Effat Alemzadeh, Esmat Alemzadeh, Maryam Barghi, Mohammad Zarei and Hamid Salehiniya (Iran - Cell Tissue Bank).
A Comparative Analysis of the Structure and Biological Properties of Films and Microfibrous Scaffolds Based on Silk Fibroin - Mdpi.com
Article by Liubov Safonova, Maria Bobrova, Anton Efimov, Alexey Lyundup, Olga Agapova and Igor Agapov (Moscow, Russia - Pharmaceutics).
The high regenerative potential of the constructions was demonstrated in a rat full-thickness skin wound healing model. The constructions accelerated healing by an average of 15 days and can be considered to be promising constructions for various tasks of tissue engineering and regenerative medicine.
Researchers use white blood cells to accelerate wound healing - Clarepeople.com
In Switzerland, researchers have discovered a new way to accelerate wound healing: the Natural Killer (NK) cells, which constitute our body’s first line of defense. Part of the innate immune system, these cells are our white blood cells, which were once known to organize and kill cancer cells or virus-infected cells. Now they are also used for healing, but with some temporary limitations.
Single use negative pressure wound therapy in vascular patients: clinical and economic outcomes - PubMed
Abstract by Marald Wikkeling, Judith Mans and Timothy Styche (The Netherlands, UK - J Wound Care).
Comparison of closed incision negative pressure wound therapy with conventional dressing for reducing wound complications in emergency laparotomy - PubMed
Abstract by Arun Garg, Sneh Jayant, Arun Kumar Gupta, Lalit Kumar Bansal, Abid Wani and Poras Chaudhary (New Delhi, India - Pol Przegl Chir.).
Smart wound dressings for wound healing - Sciencedirect.com
Abstract by Ruonan Dong and Baolin Guo (Xi’an, China - Nanotoday).
Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice - Mdpi.com
Article by Pei-Lin Shao, Jiunn-Der Liao, Shun-Cheng Wu, Yu-Hsing Chen and Tak-Wah Wong (Tainan, Taiwan - IJMS).
A short-term microplasma treatment (applied for 30 s twice a day) demonstrated comparable or better efficacy to conventional NPWT (applied for 4 h once a day) in promoting wound healing in diabetic mice.
Lasers in Wound Healing - Hmpgloballearningnetwork.com
This month the authors will examine the evidence on laser stimulation of healing. While the conclusions may not all be “goodness and light,” there are areas where efficacy seems promising and some where evidence of efficacy is clearly lacking.
Photo-Crosslinked Gelatin-Based Hydrogel Films to Support Wound Healing - PubMed
Abstract by Birgit Stubbe, Arn Mignon, Lana Van Damme, Karel Claes, Henk Hoeksema, Stan Monstrey, Sandra Van Vlierberghe and Peter Dubruel (Belgium - Macromol Biosci.).
Vascularization in skin wound healing: where do we stand and where do we go? - Sciencedirect.com
Abstract by Helena R. Moreira and Alexandra P. Marques (Portugal - Current Opinion in Biotechnology).
Acute Skin Wounds Treated with Mesenchymal Stem Cells and Biopolymer Compositions Alone and in Combination: Evaluation of Agent Efficacy and Analysis of Healing Mechanisms - Mdpi.com
Article by Ekaterina Silina, Victor Stupin, Natalia Manturova, Vitaly Vasin, Konstantin Koreyba, Petr Litvitskiy, Alexander Saltykov and Zalim Balkizov (Moscow, Russia - Pharmaceutics).
The authors studied the efficacy of using mesenchymal stem cells (MSC) and a polymeric compound (based on chitosan and cellulose with integrated cerium dioxide nanoparticles (PCCD)) in wound healing, and to compare the effects with various invasive and external drugs used for the same purpose.
Peripheral Artery Disease (PAD) and Wound Healing - Royalexaminer.com
Peripheral Artery Disease (PAD) is a condition that develops when the arteries that supply blood to the internal organs, arms and legs become completely or partially blocked. This blockage is caused by fatty plaque deposits that harden arteries, called atherosclerosis, and greatly reduces blood flow.
PAD affects nearly 10 million people in the United States, especially those over 65 years of age.
Factors Influencing Hypertrophic Scarring after Thyroidectomy - PubMed
Abstract by Hang Xie, Ying Xiang, E Yang and HengShu Zhang (Chongqing, China - Adv Skin Wound Care).
Effect of Microgravity on Endothelial Cell Function, Angiogenesis, and Vessel Remodeling During Wound Healing - Frontiersin.org
Article by Lucia Morbidelli, Shirley Genah and Francesca Cialdai (Italy - Front. Bioeng. Biotechnol.).
The understanding of the factors and mechanisms that control angiogenesis and their change following unloading conditions (in a real or simulated space environment) will allow to optimize the tissue response in case of traumatic injury or medical intervention. The potential countermeasures under development to optimize the reparative angiogenesis that contributes to tissue healing on Earth will be discussed in relation to their exploitability in space.
Advances in Wound Care Technology: What We See Is What We Get … and More - Hmpgloballearningnetwork.com
Article by Frank Aviles Jr. Today, dressing technology has transitioned from a passive to an active role. Yet, the sophistication of dressings that our patients enjoy today would not be possible without understanding the clinical progression that has occurred, even among those treatments that have since been abandoned.
Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement - Nature.com
Article by Ani Korhonen, Erika Gucciardo, Kaisa Lehti and Sirpa Loukovaara (Finland, Sweden, Norway - Scientific Reports).
The authors' findings demonstrate the complexity of proliferative diabetic retinopathy fibrovascular tissue formation and provide avenues for the development of novel treatments.
Compounds from Vernonia arborea Buch.-Ham. Inhibit Microbes that Impair Wound Healing - Journaljpri.com
Absract by Lalitha Vaidyanathan and T. Sivaswamy Lokeswari (Journal of Pharmaceutical Research International).
Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation - Biomedcentral.com
Article by Aiping Liu, Yin Long, Jun Li , Long Gu , Aos Karim, Xudong Wang and Angela L. F. Gibson (Madison, USA - Journal of Nanobiotechnology).
The authors' results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efficient wound healing therapy for use in human wounds.
Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes - Mdpi.com
Article by Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang and Seung-Yeol Nah (Korea - IJMS).
The authors' results indicate that gintonin may promote wound healing through LPA receptor activation and/or VEGF release-mediated downstream signaling pathways. Thus, gintonin could be a beneficial substance to facilitate skin wound healing.
Collagen-derived dipeptide Pro-Hyp administration accelerates muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall in mice - Nature.com
Article by Shiro Jimi, Seiko Koizumi, Kenji Sato, Motoyasu Miyazaki and Arman Saparov (Japan, Kazakhstan - Scientific Reports).
The authors' results indicated that Pro-Hyp administration accelerates muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall.
Closure of a Difficult-to-Manage Chronic Pressure Injury with the Use of Autologous Platelet-Rich Plasma (APRP) - Dovepress.com
Article by Gina Xihomara Rojas Mora, Jesús Armando Sánchez Godoy, Rodrigo Alberto Heredia Ramirez, María José Fernández Sánchez and Lina Andrea Gómez (Colombia - International Medical Case Reports Journal).
The case of a patient with chronic pressure injury who has been treated with APRP is presented, achieving resolution of the lesion.
Sprayed copper peroxide nanodots for accelerating wound healing in a multidrug-resistant bacteria infected diabetic ulcer - PubMed
Abstract by Ran Zhang, Guhua Jiang, Qianqian Gao, Xiaona Wang, Yilin Wang, Xin Xu, Wenjing Yan and Haijun Shen (China - Nanoscale).
Does Incisional Negative Pressure Wound Therapy Prevent Sternal Wound Infections? - PubMed
Abstract by Heidi-Mari Myllykangas, Jari Halonen, Annastiina Husso, Helli Väänänen and Leena T Berg (Finland - Thorac Cardiovasc Surg.).
Effects of Extracorporeal Shock Waves on Microcirculation and Angiogenesis in the in vivo Wound Model of the Diver Box - PubMed
Abstract by Heiko Sorg, Inga Zwetzich, Daniel Johannes Tilkorn, Jonas Kolbenschlag, Jörg Hauser, Ole Goertz, Nick Spindler, Stefan Langer and Andrej Ring (Germany - Eur Surg Res.).
Diabetic Foot Ulcer Prevention Strategies - Woundsource.com
Wound care specialists encounter diabetic foot ulcers regularly in the clinic, and these wounds can be very difficult to treat because of the underlying metabolic insufficiency. This blog provides a guide to current best practices with regard to DFUs and prevention.
Dermal Lesions - Woundsource.com
A dermal lesion refers to any change in the normal condition of the skin. Dermal lesions, or skin lesions, can be grouped into two categories: primary and secondary lesions. A primary dermal lesion is an abnormality that has been present from birth or acquired later in life.
Diabetic Foot Ulcers and Pressure Injuries: How Do You Tell the Difference? - Woundsource.com
Article by Dianne Rudolph. In evaluating a patient with a wound on the foot, a question that often comes to mind is whether that wound is caused by pressure, diabetes mellitus, ischemia, trauma, or a combination.
Haemostatic materials for wound healing applications - Nature.com
Abstract by Baolin Guo, Ruonan Dong, Yongping Liang and Meng Li (Xi’an, China - Nature Reviews Chemistry).
Human body-based self-powered wearable electronics for promoting wound healing driven by biomechanical motions - Sciencedirect.com
Abstract by Dong Wan, Jing Yang, Xiaojing Cui, Ningchen Ma, Zhaosu Wang, Yanping Li, Pengwei Li, Yixia Zhang, Zong-Hong Lin, Shengbo Sang and Hulin Zhang (China, Taiwan - Nano Energy).
"Elephant-trunk" negative pressure wound therapy for fixing artificial dermis with basic fibroblast growth factor for critical limb ischemia - PubMed
Abstract by Yosuke Niimi, Kan Nakamoto, Wataru Kamei, Nagisa Osa, Keijiro Hori and Hiroyuki Sakurai (Tokyo, Japan - Regen Ther.).
The content and effectiveness of self-management support interventions for people at risk of pressure ulcers: A systematic review - PubMed
Abstract by Marscha Engelen, Sandra van Dulmen, Hester Vermeulen, Erik de Laat and Betsie van Gaal (The Netherlands - Int J Nurs Stud.).
Modern Wound Dressings: Hydrogel Dressings - Mdpi.com
Article by Valentin Brumberg,Tatiana Astrelina,Tatiana Malivanova and Alexander Samoilov (Moscow, Russia - Biomedicines).
This mini review is focused on different types of traditional and modern WDs with an emphasis on hydrogels. Advantages and disadvantages of traditional and modern wound dressings as well as their applicability to different chronic wounds are elucidated.
Characterisation of Rapid In Situ Forming Gelipin Hydrogel for Future Use in Irregular Deep Cutaneous Wound Healing - Mdpi.com
Article by Dewi Utami Nike, Haliza Katas, Nor Fatimah Mohd, Yosuke Hiraoka, Yasuhiko Tabata, Ruszymah Bt Hj Idrus and Mh Busra Fauzi (Malaysia, Japan - Polymers).
The authors' findings indicated that gelipin has excellent physicochemical properties and acceptable biocompatibility as an acellular rapid treatment for future use in irregular deep cutaneous wounds.
Innovations And Emerging Technologies In Wound Care - Gineersnow.com
For healthcare professionals, wound care management plays a significant part in their ability to provide a positive outcome for patients. There have been a lot of recent innovations in the area of wound care that help prevent bleeding extremely fast. This is a huge market as the global advanced wound care market is expected to exceed $14 billion by 2026.
A prospective, randomized, controlled clinical study on the effectiveness of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of diabetic ulcers of the lower extremities - PubMed
Abstract by Robert S Kirsner, Dmitry Zimnitsky and Michael Robinson (USA, UK - Wound Repair Regen.).
Pressure ulcers microbiota dynamics and wound evolution - Nature.com
Article by Catherine Dunyach-Remy, Florian Salipante, Jean-Philippe Lavigne, Maxime Brunaud, Christophe Demattei, Alex Yahiaoui-Martinez, Sophie Bastide, Claire Palayer, Albert Sotto and Anthony Gélis (Nîmes, France - Scientific Reports).
The studied pathogroup could be a marker of wound degradation and Proteus could represent a promising target in PU management.
Editorial: Understanding Diabetic Foot Disease: Current Status and Emerging Treatment Approaches - Frontiersin.org
Article by Nikolaos Tentolouris, Michael E. Edmonds, Edward B. Jude, Prashanth R. J. Vas, Chris A. Manu, Anastasios Tentolouris and Ioanna Eleftheriadou (Greece, UK - Front. Endocrinol.).
The manuscripts in this Research Topic describe several aspects of diabetic foot disease from the pathophysiological point of view, the importance of nutritional deficiencies, the early identification of the foot at risk, all through the association of diabetic foot syndrome with other diabetic complications.
Antibacterial nanozymes: Healing chronic wounds with nanochemistry - Phys.org
Chronic infected wounds are often highly problematic for diabetic patients. However, a team of Chinese researchers has now developed a targeted approach to wound healing that makes use of nanomedicine, and their research has been published in the journal Angewandte Chemie. The researchers were able to deactivate wound-infecting bacteria using a solution of nanocapsules that alter the wound environment and unleash reactive oxygen species.
Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation - Mdpi.com
Article by Julie R. Youssef, Nabila A. Boraie, Heba F. Ibrahim, Fatma A. Ismail and Riham M. El-Moslemany (Alexandria, Egypt - Pharmaceutics).
In vivo studies on a rat model of a full-thickness wound presented rapid closure with enhanced histological and immunohistochemical parameters, revealing the success of the scaffold in reducing inflammation and promoting wound healing without scar formation.
Wound-Healing Potential of Cucurbita moschata Duchesne Fruit Peel Extract in a Rat Model of Excision Wound Repair - Hindawi.com
Article by Saba Shaygan, Sajad Fakhri, Gholamreza Bahrami, Khodabakhsh Rashidi and Mohammad Hosein Farzaei (Kermanshah, Iran - Advances in Pharmacological and Pharmaceutical Sciences).
Given the obtained data from the authors' study, the hydroalcoholic extract of Cucurbita moschata Duchesne fruit peel is proposed to be effective in accelerating the process of excision wound repair partly due to its antioxidant effect in terms of decreasing nitrite concentration.
Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing - Hindawi.com
Article by Jianghong Huang, Jun Zhang, Jianyi Xiong, Shuqing Sun, Jiang Xia, Lei Yang and Yujie Liang (China - Stem Cells International).
This review can help researchers explore new treatment strategies to enhance the therapeutic efficacy of stem cell-derived nanovesicles, which have a promising future as naturally cell-free therapies.
Do Bioactive Sutures Improve Wound Healing? - Escholarship.org
Article by Behrad Taghdiri (San Diego, USA).
The purpose of this article is to focus primarily on MSC-coated bioactive sutures enhance the process of wound healing by providing sufficient resources to the wounded area. In this article, literature studying the effect of MSCs bioactive sutures on wound healing will be discussed, and further analysis and recommendations for future work will be provided.
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway - Nature.com
Article by Kailun Zhang, Bo Chai, Hao Ji, liuqing Chen, Yanbing Ma, Lifei Zhu, Jingyu Xu, Yanqing Wu, Yinan Lan, Hao Li, Zhiguo Feng, Jian Xiao, Hongyu Zhang and Ke Xu (Zhejiang, China - Laboratory Investigation).
This study showed that bioactive glass can accelerate wound closure, granulation formation, collagen deposition, and angiogenesis. Moreover, western blot analysis and immunofluorescence staining revealed that bioactive glass inhibited the expression of pyroptosis-related proteins in vivo and in vitro.
The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway - Frontiersin.org
Article by Miho Takahashi, Yoshie Umehara, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda and François Niyonsaba (Tokyo, Japan - Front. Immunol).
The authors indeed confirmed that hBD-3 enhanced the phosphorylation of FGFR1, JAK2 and STAT3. Collectively, the current study provides novel evidence that hBD-3 might be a potential candidate for the treatment of wounds through its ability to promote wound healing, angiogenesis and fibroblast activation.
Complementary Effect of Non-Persistent Silver Nano-Architectures and Chlorhexidine on Infected Wound Healing - Mdpi.com
Article by Mykola Pernakov, Maria Laura Ermini, Oksana Sulaieva, Domenico Cassano, Marco Santucci, Yevhenia Husak, Viktoriia Korniienko, Giulia Giannone, Aziza Yusupova, Iryna Liubchak, Maria Teodora Hristova, Anton Savchenko, Viktoriia Holubnycha, Valerio Voliani and Maksym Pogorielov (Ukraine, Italy, Canada, Bulgaria, Poland - Biomedicines).
The authors' findings open the way for the composition of robust multifunctional nanoplatforms for the translation of safe and efficient topical treatments of surgical site infection.
Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing - PubMed
Abstract by Jingfeng Yuan, Dong Zhang, Xiaomin He, Yifeng Ni, Lingbin Che, Jiang Wu, Baoyi Wu, Yang Wang, Shuguang Wang, Dongyong Sha, Si Yu Zheng and Jintao Yang (China, USA - Int J Biol Macromol.).
A review of medicinal plant-based bioactive electrospun nano fibrous wound dressings - Sciencedirect.com
Article by Biruk Fentahun Adamu, Jing Gao, Abdul Khalique Jhatial and Degu Melaku Kumelachew (China, Ethiopia, Pakistan - Materials & Design).
This review provides a broad overview of latest medicinal plant incorporated bioactive electrospun nanofibrous wound dressing researches and developments. It also discussed the therapeutic properties of different traditional medicinal plants.
Innovative wound healing that utilises the body’s own defence system - Healtheuropa.eu
Colzyx is developing a new generation of bioactive wound dressing that accelerates healing and combats infections, including those that are multi-drug resistant.
Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review - Mdpi.com
Article by Swee Ching Tan, Subrat Kumar Bhattamisra, Dinesh Kumar Chellappan and Mayuren Candasamy (Kuala Lumpur, Malaysia - Applied Sciences).
This review, while including other major constituents of this plant, focuses on the therapeutic potential, pharmacokinetics and toxicity of madecassoside.
Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing - PubMed
Abstract by Reena Bhadhwar, Bharti Mangla, Yub Raj Neupane, Kushagra Khanna and Harvinder Popli (India, Singapore - Nanotechnology).
Human Infections by Wohlfahrtiimonas chitiniclastica: A Mini-Review and the First Report of a Burn Wound Infection after Accidental Myiasis in Central Europe - Mdpi.com
Article by Martin Hladik, Bretislav Lipovy, Yvona Kaloudova, Marketa Hanslianova, Ivana Vitkova, Tereza Deissova, Tomas Kempny, Martin Svoboda, Zdenek Kala, Pavel Brychta and Petra Borilova Linhartova (Czech Republic - Microorganism).
Accidental myiasis is no longer the domain of only subtropical or tropical regions; with climate change, the likelihood of its occurrence, especially in people with low socioeconomic status, increases in temperate climates as well. In individuals with unsterile parasitic larvae infestation, infection by rare pathogens, such as W. chitiniclastica, can be suspected.
Re-opening old wounds - vitamin C and wound healing deserve a re-examination - Academic.oup.com
Abstract by Margreet C M Vissers and Juliet M Pullar (The American Journal of Clinical Nutrition).
Wound healing potential of licorice extract in rat model: Antioxidants, histopathological, immunohistochemical and gene expression evidences - PubMed
Abstract by Doaa H Assar, Nagwan Elhabashi, Abd-Allah A Mokhbatly, Amany E Ragab, Zizy I Elbialy, Sally A Rizk, Aishah E Albalawi, Norah A Althobaiti, Soad Al Jaouni and Ayman Atiba (Egypt, Saudi Arabia - Biomed Pharmacother.).
Placement of wound drain after anterior circulation aneurysm clipping: a single-center retrospective study - PubMed
Abstract by Yuankun Cai, Tingbao Zhang, Guo Li, Zheng Liu, Jincao Chen and Kui Liu (Wuhan, China - World Neurosurg.).
Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration - PubMed
Abstract by Steffen Emmert, Sven Pantermehl, Aenne Foth, Janine Waletzko-Hellwig, Georg Hellwig, Rainer Bader, Sabine Illner, Niels Grabow, Sander Bekeschus, Klaus-Dieter Weltmann, Ole Jung and Lars Boeckmann (Germany - Int J Mol Sci.).
A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers - Mdpi.com
Article by Paramjit S. Tappia, Brett Hiebert, Rohan Sanjanwala, Paul Komenda, Chris Sathianathan, Amarjit S. Arneja and Bram Ramjiawan (Winnipeg, Canada - Applied Sciences).
This pilot study is suggestive that bathing in CO2-enriched water may accelerate the healing of foot ulcers.
Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends - Hindawi.com
Article by Dhinakaran Veeman, M. Swapna Sai, P. Sureshkumar, T. Jagadeesha, L. Natrayan, M. Ravichandran and Wubishet Degife Mammo (India, Ethiopia - International Journal of Polymer Science).
The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.
New Insights on Wound Healing Unraveled - Genengnews.com
Despite advancements in treating wounds, the molecular mechanisms behind wound healing is not fully understood. Now, researchers at the University of California, Irvine (UCI), have identified a new molecular pathway that promotes wound healing in the skin. Their findings could even play a role in nonhealing wounds.
Effect of Soft Silicone Foam Dressings on Intraoperatively Acquired Pressure Injuries: A Randomized Study in Patients Undergoing Spinal Surgery - PubMed
Abstract by Tae-Yeong Yang and Sung Hee Shin (Seoul, Korea - Wound Manag Prev.).
Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment - Mdpi.com
Article by Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin and Zlatko Kopecki (Australia - Biomedicines).
The authors' findings suggest that the developed AgNP hydrogel has the potential to be a safe wound treatment capable of eliminating infection and providing a safe yet effective strategy for the treatment of infected wounds.
Natural killer cells mediate a trade-off between wound healing and bacterial defense - News-medical.net
Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune defense is weakened, researchers at the University of Zurich have now shown.
Burns and biofilms: priority pathogens and in vivo models - Nature.com
Article by Evgenia Maslova, Lara Eisaiankhongi, Folke Sjöberg and Ronan R. McCarthy (UK, Sweden - npj Biofilms and Microbiomes).
In this review, the authors discuss some of the leading burn wound pathogens and outline how they regulate biofilm formation in the burn wound microenvironment. They also discuss the new and emerging models that are available to study burn wound biofilm formation in vivo.
Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds - Mdpi.com
Article by Andreea Barbu, Bogdan Neamtu, Marius Zăhan, Gabriela Mariana Iancu, Ciprian Bacila and Vioara Mireșan (Romania - JPM).
This paper explores the roles of alginates in advanced wound-dressing forms with a particular emphasis on hydrogels, nanofibers networks, 3D-scaffolds or sponges entrapping fibroblasts, keratinocytes, or drugs to be released on the wound-bed.
Factors That Delay Wound Healing in Venous Leg Ulcerss - Woundsource.com
Wound chronicity takes place in wounds that are stalled and/or remain unhealed after four to six weeks. Although evidence-based care has been established, it has been reported that 30% of patients still experience delayed healing, with wounds often failing to heal within a 24-week time frame. Identifying risk factors for VLUs is imperative in best outcomes.
Gelatin-Based Versus Alginate-Based Hydrogels: Providing Insight in Wound Healing Potential - PubMed
Abstract by Oana Maria Ionescu, Arn Mignon, Manon Minsart, Jasper Van Hoorick, Ioannis Gardikiotis, Irina-Draga Caruntu, Simona Eliza Giusca, Sandra Van Vlierberghe and Lenuta Profire (Romania, Belgium - Macromol Biosci.).
The modified TIME-H scoring system, a versatile tool in wound management practice: a preliminary report - PubMed
Abstract by Giuseppe Guarro, Federico Cozzani, Matteo Rossini, Elena Bonati and Paolo Del Rio (Parma, Italy - Acta Biomed.).
Endothelial Heterogeneity in Development and Wound Healing - Mdpi.com
Article by David B. Gurevich, Deena T. David, Ananthalakshmy Sundararaman and Jatin Patel (UK, India, Australia - Cells).
In this review, the authors will pinpoint the seminal discoveries defining the phenotype and mechanisms of endothelial heterogeneity in development and disease, with a specific focus only on wound healing.
Experimental Study of the Effect of Photobiomodulation Therapy on the Regulation of the Healing Process of Chronic Wounds - Hindawi.com
Article by Sergey B. Pavlov, Nataliia M. Babenko, Marina V. Kumetchko, Olga B. Litvinova and Rostyslav N. Mikhaylusov (Kharkiv, Ukraine - International Journal of Photoenergy).
The results of the histological examination indicated a positive effect of photobiomodulation therapy with the applied parameters on the repair processes of chronic wounds.
Synthetic Exosomes Can Optimize Wound Healing - Technologynetworks.com
Scientists from the Max Planck Institute for Medical Research in Heidelberg and colleagues at the DWI Leibniz Institute for Interactive Materials in Aachen have engineered synthetic exosomes that regulate cellular signaling during wound closure.
The scientists uncovered key mechanisms to regulate and aid wound healing and the formation of new blood vessels.
The application of enhanced recovery after surgery and negative-pressure wound therapy in the perioperative period of elderly patients with colorectal cancer - Biomedcentral.com
Article by Han-rong Liu, Ping Yang, Song Han, Yu Zhang and Hui-yin Zhu (Shanghai, China - BMC Surgery).
The modified enhanced recovery after surgery (ERAS) can be safely applied to the perioperative period of elderly colorectal cancer patients and promote recovery; negative-pressure wound therapy is helpful for wound healing and promoting rehabilitation.
Disrupting biological sensors of force promotes tissue regeneration in large organisms - Nature.com
Article by Kellen Chen, Sun Hyung Kwon, […]Geoffrey C. Gurtner (USA, Germany - Nature Communications).
In human cells, the authors demonstrate that mechanical forces shift fibroblasts toward pro-fibrotic phenotypes driven by ERK-YAP activation, leading to myofibroblast differentiation and excessive collagen production. Disruption of mechanical signaling specifically abrogates these responses and instead promotes regenerative fibroblast clusters characterized by AKT-EGR1.
FDA Clears Drug-Device Combination Matrix for Chronic Wound Care - Hcplive.com
Article by Connor Iapoce.
The wound care matrix is composed of hydrolyzed fish collagen infused with cod liver oil and other plant-derived oil and wax to aid in the natural wound healing process.
In vitro methods used for discovering plant derived products as wound healing agents - An update on the cell types and rationale - PubMed
Abstract by Jun Sheng Low, Kit-Kay Mak, Zhang Shiming, Mallikarjuna Rao Pichika, Puvaneswari Marappan, Kavitha Mohandas and Madhu Katyayani Balijepalli (Malaysia - Fitoterapia).
The Role of Family Caregivers in Pressure Injury Prevention Guidelines: A Scoping Review - PubMed
Abstract by Hossein Rafiei, Zohreh Vanaki, Eesa Mohammadi and Kazem Hosseinzadeh (Home Healthc Now).
Topical Cream Effective Against Diabetic Foot Ulcers - Medpagetoday.com
Article by Jeff Minerd.
A topical cream that helps regulate macrophage activity was effective in treating diabetic foot ulcers, a clinical trial reported. In 236 patients with foot ulcers treated for 16 weeks, the proportion who had complete healing of the ulcer was significantly higher in the group randomized to receive the topical cream (60.7%) versus a comparator group treated with absorbent dressing.
Treating chronic wounds effectively: The unmet need - Med-technews.com
Article by Sam Bakri.
Wound healing is a lengthy and extraordinarily complex set of biological processes. If a patient with a wound has underlying chronic diseases, their reparative, restorative biological mechanisms are compromised, resulting in wounds never healing on their own.
Products and technologies for treating patients with evidence-based pressure ulcers - PubMed
Abstract by Tatiana Neves Figueira, Marli Terezinha Stein Backes, Neide da Silva Knihs, Isabel Cristina Alves Maliska, Lúcia Nazareth Amante and Maria Lígia Dos Reis Bellaguarda (Santa Catarina, Brazil - Rev Bras Enferm.).
Healing Rate of Diabetic Foot Wounds When Treated with Serial Debridement in the Presence of Antithrombotic Therapy - PubMed
Abstract by Jack Roue (J Am Podiatr Med Assoc.).
Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo - Mdpi.com
Article by Ben Chung Lap Chan, Priyanga Dharmaratne, Baiyan Wang, Kit Man Lau, Ching Ching Lee, David Wing Shing Cheung, Judy Yuet Wa Chan, Grace Gar Lee Yue, Clara Bik San Lau, Chun Kwok Wong, Kwok Pui Fung and Margaret Ip (China - Pharmaceutics).
High prevalence rates of methicillin-resistant Staphylococcus aureus (MRSA) and lack of effective antibacterial treatments urge discovery of alternative therapeutic modalities. The advent of antibacterial photodynamic therapy (aPDT) is a promising alternative, composing rapid, nonselective cell destruction without generating resistance.
Use of Blue Light in the Management of Chronic Venous Ulcer in Asian Patients: A Case Series - Cureus.com
Article by Vanessa B. Khoo, Shereen Soon, Charyl J. Yap, Siew Ping Chng and Tjun Y. Tang.
The cases demonstrated that photobiomodulation therapy (PBMT) with blue light was well-tolerated, safe, and efficacious in improving wound healing with an adjunct to standard treatment of chronic venous ulcers.
Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-β/Smad Signaling Pathway - Hindawi.com
Article by Zha Ru, Ying Hu, Shenghua Huang, Li Bai, Kun Zhang and Yue Li (Guangzhou, China - Evidence-Based Complementary and Alternative Medicine).
The authors' data indicated that Galangin can alleviate dermal scarring via the TGF-β/Smad signaling pathway probably by upregulating Smad 7 expression and, thus, suppressing the expression of type I and type III collagens and TGF-β1.
A Randomized Controlled Trial to Assess the Cost-effectiveness of a Novel, Simple Modification to the Negative Pressure Wound Therapy System - PubMed
Abstract by Waleed K Albayati, Sarah Al Youha, Ali A Ali and Zainab Fakhra (Iraq, Canada, Kuwait - Plast Reconstr Surg Glob Open).
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice - Nature.com
Article by Duy Dinh Do Pham, Věra Jenčová, Miriam Kaňuchová, Jan Bayram, Ivana Grossová, Hubert Šuca, Lukáš Urban, Kristýna Havlíčková, Vít Novotný, Petr Mikeš, Viktor Mojr, Nikifor Asatiani, Eva Kuželová Košťáková, Martina Maixnerová, Alena Vlková, Dragana Vítovská, Hana Šanderová, Alexandr Nemec, Libor Krásný, Robert Zajíček, David Lukáš, Dominik Rejman and Peter Gál (Czech Republic, Slovak Republic - Scientific Reports).
The authors demonstrated in vitro that LPPO released from NANO exerted antibacterial activity while not impairing proliferation/differentiation of fibroblasts and keratinocytes. Secondly, using a mouse model they showed that NANO loaded with LPPO significantly reduced the Staphylococcus aureus counts in infected wounds as evaluated 7 days post-surgery.
The Biomechanics of Diabetic Foot Amputation - Hmpgloballearningnetwork.com
Article by James B. McGuire, Avery Thomson and Pamela Genise Kennedy.
By reviewing recent data on these amputations, the authors hope to help surgeons choose the appropriate level for intervention and highlight areas of weakness in the literature requiring further investigation.
Foot Revascularization Avoids Major Amputation in Persons with Diabetes and Ischaemic Foot Ulcers - Mdpi.com
Article by Marco Meloni, Daniele Morosetti, Laura Giurato, Matteo Stefanini, Giorgio Loreni, Marco Doddi, Andrea Panunzi, Alfonso Bellia, Roberto Gandini, Enrico Brocco, José Luis Lazaro-Martinez, Davide Lauro and Luigi Uccioli (Italy, Spain - JCM).
Failed foot revascularization resulted an independent predictor of non-healing, minor amputation, and major amputation. Foot revascularization is mandatory to achieve healing and avoid major amputation in persons with ischaemic DFU and BTA arterial disease.
Predicting the different progressions of early pressure injury by ultraviolet photography in rat models - PubMed
Abstract by Huiwen Xu, Yanwei Wang, En Takashi, Akio Kamijo, Daiji Miura, Kunie Karasawa, Akio Kitayama, Jian Lu and Lan Zhang (Japan, China - Int Wound J.).
Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing - Mdpi.com
Article by Daniela Miricescu, Silviu Constantin Badoiu, Iulia-Ioana Stanescu-Spinu, Alexandra Ripszky Totan, Constantin Stefani and Maria Greabu (Bucharest, Romania - IJMS).
The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.
Growth Factors, Reactive Oxygen Species, and Metformin - Promoters of the Wound Healing Process in Burns? - Mdpi.com
Article by Abd. Kakhar Umar, Sriwidodo Sriwidodo, Iman Permana Maksum and Nasrul Wathoni (Sumedang, Indonesia - Molecules).
This study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing.
Injectable Methylcellulose and Hyaluronic Acid Hydrogel Containing Silver Nanoparticles for Their Effective Anti-microbial and Wound Healing Activity After Fracture Surgery - Springer.com
Article by Jianping Yu, Liying Cheng, Zhongwei Jia, Xiaojing Han, Huan Xu and Jianye Jiang (China - Journal of Polymers and the Environment).
The authors report the synthesis and characterization of methylcellulose and hyaluronic acid (MC–HA) hydrogels containing AgNPs dressing materials were investigated for their wound healing efficiency to treat surgical excision wounds and the findings were studied and discussed.
Take A Load Off: Offloading Tips And Pearls In Wound Care - Hmpgloballearningnetwork.com
Article by James B. McGuire.
Diabetic foot ulcerations (DFUs) affect approximately 26 million people worldwide, with a staggering 2.5 times increased risk of death at five years. While many etiologies and conditions contribute to a wound, offloading is crucial to solving the wound healing puzzle.
Smart Wound Dressings with Built-In Healing Sensors - Healthtechprogress.com
Researchers have developed smart wound dressings with built-in nanosensors that glow to alert patients when a wound is not healing properly. The multifunctional, antimicrobial dressings feature fluorescent sensors that glow brightly under UV light if infection starts to set in and can be used to monitor healing progress.
Converting fibroblastic fates leads to wound healing without scar - Nature.com
Article by Dongsheng Jiang and Yuval Rinkevich (Munich, Germany - Signal Transduction and Targeted Therapy).
Further investigation building on the basis of the work from Mascharak et al. and others would lead to achieve the ultimate goal of a scarless wound healing.
Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers - Mdpi.com
Article by Robert G. Frykberg (Glendale, USA). This review shall provide a brief summary of the role of oxygen in wound healing and, specifically, discuss the different types of topical oxygen devices and associated studies that have convincingly shown their efficacy in healing chronic diabetic foot ulcers.
Oxygen-delivering hydrogel accelerates diabetic wound healing - Newswise.com
Jianjun Guan, professor of mechanical engineering and materials science at the McKelvey School of Engineering at Washington University in St. Louis, has developed a hydrogel that delivers oxygen to a wound, which decreases inflammation, helps remodel tissue and accelerates healing.
In vitro fibroblasts viability and migration stimulation of Acalypha indica: an insight on wound healing activity - Springer.com
Article by Ammar Mahmoud Ibrahim, Mariani Abdul Hamid, Rama Ali Althiab, Amir Husni Mohd Shariff and Razauden Mohamed Zulkifli (Johor, Malaysia - Future Journal of Pharmaceutical Sciences).
This study provided evidence for Acalypha indica to have great wound healing potential. The finding builds the scientific background in future to utilise the high antioxidant activity of A. indica and its ability to stimulate fibroblasts migration and proliferation for further applications.
The History and Effectiveness of Negative Pressure Wound Therapy (NPWT) - Part One - Hmpgloballearningnetwork.com
In part one of this three-part NPWT educational series offered in partnership with ExtriCARE USA, the authors will explore the history of NPWT, what makes it clinically effective and who can benefit from this promising treatment as it continues to advance.
Medical gas plasma-stimulated wound healing: Evidence and mechanisms - Sciencedirect.com
Article by Sander Bekeschus, Thomas von Woedtke, Steffen Emmert and Anke Schmidt (Germany - Redox Biology).
This review integrates preclinical and clinical evidence into a set of working hypotheses mainly based on redox processes aiding in elucidating the mechanisms of action and optimizing gas plasmas for therapeutic purposes.
Researchers take step toward using cellular motion to help wound healing - Phys.org
Article by Patricia Waldron.
In a new study, the researchers overcame the inertia typical of mature skin tissue by breaking the molecular connections between cells, applying an electrical field to direct their migration and then rebuilding the connections. This novel approach improves the controllability of tissues and may one day help optimize wound healing through electrical stimulation.
Marine mussels are a model for improving strength, stretchiness and adhesion in hydrogels for wound healing - Phys.org
Hydrogels simulate living tissue for tissue replacement or regeneration. One of the most useful of these applications is for healing wounds. Hydrogels are ideal for this purpose, with their ability to hydrate and form a moist and supportive environment. This facilitates processes beneficial for wound healing, such as blood vessel formation, the breakdown of dead tissue, activation of immune cells, the prevention of live cell and tissue death and even the alleviation of pain.
Negative pressure wound therapy following excision of pilonidal sinus disease: A retrospective review - PubMed
Abstract by Enda Hannan, Tim Harding, Hanna Feizal and Sean Martin (Dublin, Ireland - Colorectal Dis.).
Stem Cell Therapy for Burns: Story so Far - Dovepress.com
Article by Najath Abdul Kareem, Ayesha Aijaz and Marc G Jeschke (Toronto, Canada - Biologics: Targets and Therapy).
This paper reviews in detail the different sources of stem cells, stem cell-derived products, their efficacy in burn wound repair, associated signaling pathways and modes of delivery for wound healing.
Fabrication and characterization of an antibacterial chitosan/silk fibroin electrospun nanofiber loaded with a cationic peptide for wound-dressing application - PubMed
Abstract by Sadjad Khosravimelal, Milad Chizari, Behrouz Farhadihosseinabadi, Mehrdad Moosazadeh Moghaddam and Mazaher Gholipourmalekabadi (Tehran, Iran - J Mater Sci Mater Med.).
Hydrogels - Nanowerk.com
Hydrogels are fascinating natural or synthetic polymer materials that exhibit very versatile chemistries and physical or biological properties. They are 3D networks of either physically or chemically crosslinked polymers that resemble organic tissues and that can hold large amounts of water within their interlocked molecular network.
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