Synergistic antibacterial polyacrylonitrile/gelatin nanofibers coated with metal-organic frameworks for accelerating wound repair - PubMed
Abstract by Jun Yang, Chun-Li Liu, Yi-Ning Ding, Tian-Cai Sun, Xiao-Han Bai, Zhi-Kai Cao, Seeram Ramakrishna, Jun Zhang and Yun-Ze Long (China, Singapore - Int J Biol Macromol.).
At-Risk Patient: Surgical Site Infections - Woundsource.com
Skin is a natural barrier against infection. Despite the provision of precautions and protocols to prevent infection, any surgery or procedure that breaches the skin can lead to an infection. Infections that occur on the part of the body where the surgical procedure took place are called surgical site infections (SSIs). The chances of a patient developing an SSI post-surgery are about 1% to 3%.
Medical device-related pressure injuries in critical patients: prevalence and associated factors - PubMed
Abstract by Sabrina Guterres da Silva Galetto, Eliane Regina Pereira do Nascimento, Patrícia Madalena Vieira Hermida, Josefine Busanello, Luciana Bihain Hagemann de Malfussi and Daniele Delacanal Lazzari (Brazil - Rev Esc Enferm USP).
Regulating the mechanics of silk fibroin scaffolds promotes wound vascularization - PubMed
Abstract by Peng Guo, Pan Du, Peng Zhao, Xue Chen, Chenyang Liu, Yong Du, Jiadai Li, Xiaoyu Tang, Fengbo Yang and Guozhong Lv (Jiangsu, China - Biochem Biophys Res Commun.).
Design, in vitro bioactivity and in vivo influence on oxidative stress and matrix metalloproteinases of bioglasses in experimental skin wound - PubMed
Abstract by Gabriela Adriana Filip, Marcela Achim, Paula Mihalte, Maria Olimpia Miclaus, Cecilia Cristea, Gheorghe Melinte, Bogdan Gheban, Dana Maria Munteanu, Oana Cadar, Ioan Simon, Ovidiu Pana, Lucian Barbu Tudoran, Simona Clichici and Razvan Stefan (Cluj-Napoca, Romania - J Trace Elem Med Biol.).
Noncoding RNAs and RNA-binding proteins in diabetic wound healing - PubMed
Abstract by Xue Li, Ning Li, Bingxin Li, Yuan Feng, Di Zhou and Gang Chen (China - Bioorg Med Chem Lett.).
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation - Sciencemag.org
Article by Ya Guan, Hong Niu, Zhongting Liu, Yu Dang, Jie Shen, Mohamed Zayed, Liang Ma and Jianjun Guan (St. Louis, USA - Science Advances).
The sustained release of oxygen augmented the survival and migration of keratinocytes and dermal fibroblasts, promoted angiogenic growth factor expression and angiogenesis in diabetic wounds, and decreased the proinflammatory cytokine expression. These effects significantly increased the wound closure rate. The authors' findings demonstrate that sustained oxygenation alone, without using drugs, can heal diabetic wounds.
Non-healing Wound After Mastopexy: Cautionary Case Report for a Unique Source of a Marjolin’s Ulcer of the Breast - Cureus.com
Article by Harsh Patel, Yasmina Samaha, Reva Basho, Dhivya R. Srinivasa and Alice P. Chung.
This report represents a cautionary case of the management of an open wound and highlights a previously undescribed etiology of an Marjolin's ulcers in the breast.
Health Care Spending in Patients With Stage 3 and Stage 4 Pressure Injuries and Patients With Diabetic Foot Ulcers Treated Early With Clostridial Collagenase Ointment: A Retrospective Data Review - PubMed
Abstract by Jeffrey Lehrman, Ankur Patel and Gary Delhougne (USA, UK - Wounds).
Effects of Multilayer Silicone Foam Dressings for the Prevention of Pressure Ulcers in High-Risk Patients: A Randomized Clinical Trial - PubMed
Abstract by Makoto Oe, Sanae Sasaki, Tomoko Shimura, Yoshie Takaki and Hiromi Sanada (Japan - Adv Wound Care (New Rochelle)).
Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket - Nature.com
Article by Frederick Robert Carrick, Luis Sebastian Alexis Valerio, Maxine N. Gonzalez-Vega, David Engel and Kiminobu Sugaya (USA, UK, Panama, India - Life).
The utilization of cultured adipose tissue-derived mesenchymal stem cells (cFIRB) in cellular biology and medical applications may be promising in many situations currently explored in animal and human models. This technology needs no direct or battery power source and is entirely autonomous and noninvasive, making its application possible in any environment.
Novel Cellulose Fibre-Based Flexible Plasmonic Membrane for Point-of-Care SERS Biomarker Detection in Chronic Wound Healing - Dovepress.com
Article by Jayakumar Perumal, Hann Qian Lim, Amalina Binte Ebrahim Attia, Riazul Raziq, David Ian Leavesley, Zee Upton, US Dinish and Malini Olivo (Singapore, International Journal of Nanomedicine).
The authors' SERS sensing platform achieved detection limits in the μM to sub-nM range and displayed high sensitivity and selectivity. This could result in a cheap, point-of-care device that provides a non-invasive measure of cutaneous wound healing in real time.
Antler stem cells and their potential in wound healing and bone regeneration - Wjgnet.com
Article by Wei Zhang, Chang-Hong Ke, Hai-Hua Guo and Li Xiao (China - World Journal of Stem Cells).
Antler renewal is a stem cell-based epimorphic process, and AnSCs can initiate de novo generation of antlers in postnatal mammals. Previous studies have demonstrated that AnSCs express both classic MSC and ESC markers and can be induced to differentiate into multiple cell lineages in vitro.
Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars - Nature.com
Article by Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim and Cheong Hoon Seo (Seoul, Korea - Scientific Reports).
The authors show that extracorporeal shock wave therapy regulates the proliferation and differentiation of keratinocytes derived from hypertrophic scar to maintain normal epidermal integrity.
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes - Nature.com
Article by Andrés López-Cortés, Estefanía Abarca, Leonardo Silva, Erick Velastegui, Ariana León-Sosa, Germania Karolys, Francisco Cabrera and Andrés Caicedo (Ecuador, Spain - Scientific Reports).
The authors' results show that WH and cancer's common proteins are involved in the microenvironment modification of solid tissues and immune system regulation. This set of proteins, between WH and cancer, could represent key targets for developing therapies.
Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration - Mdpi.com
Article by Steffen Emmert, Sven Pantermehl, Aenne Foth, Janine Waletzko-Hellwig, Georg Hellwig, Rainer Bader, Sabine Illner, Niels Grabow, Sander Bekeschus, Klaus-Dieter Weltmann, Ole Jung and Lars Boeckmann (Germany - IJMS).
Cold atmospheric pressure plasma reatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.
Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII - Nih.gov
Article by Daniel Kruppa Florian Peters, Olivier Bornert, Mareike D. Maler, Stefan F. Martin, Christoph Becker-Pauly and Alexander Nyström (Germany, Switzerland - Matrix Biol Plus).
The authors functionally assessed the roles of meprins in skin wound healing using mice genetically deficient in one or both meprins. Meprin deficiency did not change the course of macroscopic wound closure. However, subtle but distinct contributions of meprins to the healing process and dermal homeostasis were observed.
Partial Effect of Resveratrol on Wound Healing: Study on Wistar Albino Rats - Researchsquare.com
Article by Tayfun Bilgiç, Nazlı Caf and Ayşe Nilhan Atsü (Turkey).
Within parameters, resveratrol has been shown to be effective in wound healing in various ways. The results of this study may shed light on new therapeutic approaches that can be used in the reversal of oxidative stress in wound-causing diseases.
Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis - Mdpi.com
Article by Eberhard Grambow, Heiko Sorg, Christian G. G. Sorg and Daniel Strüder (Germany, Medical Scienes).
In this review article, the authors focus on the different levels of investigation of skin wound healing (in vivo to in virtuo) and the investigation of angiogenesis and its parameters.
The Influence of Perioperative Antibiotic Prophylaxis on Wound Infection and on the Colonization of Wound Drains in Patients After Correction of Craniosynostosis - Frontiersin.org
Article by Johannes Holle, Tobias Finger, Julia Lugonja, Florian Schmidt, Andreas Schaumann, Alexander Gratopp, Ulrich-Wilhelm Thomale, Horst von Bernuth and Matthias Schulz (Berlin, Germany - Front. Pediatr.).
Single-shot preoperative erioperative antibiotic prophylaxis is now applied to the majority craniosynostosis patients undergoing surgical correction in authors' unit.
Scientists Create 'Living Materials' That Can Self-Repair When Damaged - Newsweek.com
Article by Ed Browne.
Scientists have created "living materials" from bacteria that can repair themselves when damaged. Researchers say the materials could one day be used in medicine to improve skin repair.
Split-thickness skin graft in one-stage procedure for severe axillary hidradenitis suppurativa - PubMed
Abstract by Karolina Wójcicka, Piotr K Krajewski and Jacek C Szepietowski (Wroclaw, Poland - Dermatol Ther.).
Recent Advances in Cellulose-Based Structures as the Wound-Healing Biomaterials: A Clinically Oriented Review - Mdpi.com
Article by Mohammad Foad Abazari, Shayan Gholizadeh, Shohreh Zare Karizi, Nazanin Hajati Birgani, Danya Abazari, Simin Paknia, Hossein Derakhshankhah, Zahra Allahyari, Seyed Mohammad Amini, Masoud Hamidi and Cedric Delattre (Iran, USA, France - Applied Sciences).
This review paper revealed that cellulose-based biomaterials have promising potential as the wound-dressing/healing materials and can be integrated with various bioactive agents. Overall, cellulose-based biomaterials are shown to be effective and sophisticated structures for delivery applications, safe and multi-customizable dressings, or grafts for wound-healing applications.
Naltrexone blockade of OGFr enhances cutaneous wound closure in diabetic rats - Sciencedirect.com
Article by Patricia J. McLaughlin, Joseph W. Sassani, Indira Purushothaman and Ian S. Zagon (Hershey, USA - Medicine in Drug Discovery).
Non-healing wounds are a major complication for the 27 million individuals in the United States with diagnosed diabetes. This study investigated the efficacy of a novel formulation to treat diabetic foot ulcers by targeting an underlying pathophysiology of diabetes.
Immunomodulatory bioactive glasses for tissue regeneration - PubMed
Abstract by Kai Zheng, Wen Niu, Bo Lei and Aldo R Boccaccini (Germany, China - Acta Biomater.).
A multi-centre, single-blinded randomised controlled clinical trial evaluating the effect of resorbable glass fibre matrix in the treatment of diabetic foot ulcers - PubMed
Abstract by David G Armstrong, Dennis P Orgill, Robert D Galiano, Paul M Glat, Lawrence A DiDomenico, Marissa J Carter and Charles M Zelen (USA - Int Wound J.).
Waste-to-wealth : American bullfrog skin-derived collagen for wound dressing applications - Ntu.edu.sg
Article by Cigdem Cimenoglu (Singapore).
The effectiveness of extracted acid solubilised bullfrog skin-derived collagen - 1,4-Butanediol diglycidyl ether as a wound dressing material was partially proven by in vitro cellular studies, and further confirmation was carried out by in vivo full-thickness excisional wound healing model together with immunohistological analysis. Better integration of ABFC-BDE construct with neighbouring native tissue due to the nano-feature of the fibres led to swift epithelial tongue formation (i.e. re-epithelisation) which in turn reduced the risk of infection.
Printed Electronics and Specialty Materials Empower Next-Generation Wound Care - Mddionline.com
Article by Daphne Allen.
Research at Germany’s National Reference Center had previously demonstrated that cold plasma could kill bacteria and even fight antibiotic-resistant pathogens common in hospitals and hospice settings.
What Is the Wound Telling You? - Woundsource.com
Wound healing can stall for a number of reasons. Wounds that have not healed or significantly reduced in size after four to six weeks are considered chronic. They are characterized by a multitude of impeding factors including biofilm, excess matrix metalloproteinases (MMPs) and extracellular matrix degradation, inflammation, fibrosis, unresponsive keratinocytes and fibroblasts, and atypical growth factor signaling.
Biophotonic Treatment Accelerates Burn Wound Healing - Hospimedica.com
A new study suggests that low dose photobiomodulation (PBM) therapy can speed up recovery and reduce inflammation in third-degree burns.
Micropatterned Fibrous Scaffold Produced by Using Template-Assisted Electrospinning Technique for Wound Healing Application - Mdpi.com
Article by Norul Ashikin Norzain, Zhi-Wei Yu, Wei-Chih Lin and Hsing-Hao Su (Kaohsiung, Taiwan - Polymers).
The authors' results determined the potential of micropatterned scaffolds for stimulating cell behavior and their application for wound healing.
Use of an intraoperative sodium oxychlorosene-based infection prevention protocol to safely decrease postoperative wound infections after spine surgery - PubMed
Abstract by Vincent J Alentado, Robert P Berwanger, Anabel M Konesco, Alex J Potts, Caroline A Potts, David W Stockwell, Lana Dbeibo, John J DePowell, Eric M Horn, Saad A Khairi, Shannon P McCanna, Jean-Pierre Mobasser, Richard B Rodgers and Eric A Potts (Indianapolis, USA - J Neurosurg Spine).
Evidence-Based Wound Irrigation: Separating Fact from Fiction - PubMed
Abstract by Fouad Saeg, Anna R Schoenbrunner and Jeffrey E Janis (USA - Plast Reconstr Surg.).
At-Risk Patient: Pressure Ulcers/Injuries - Woundsource.com
A patient at-risk of developing a pressure injury is an individual who has limitations in daily living activities that could result in chronic problems if exposed to pressure, shear, friction or moisture. Bed-ridden patients, especially those with spinal cord injuries, those who are hemodynamically unstable, the elderly and the very young are primarily at risk of developing pressure ulcers.
Wound Dressing Options for Achieving Moisture Balance - Woundsource.com
Selection of a wound dressing requires a multifaceted approach. Currently, no dressing can meet all needs of a wound (infection prevention, promotion of re-epithelialization, moisture balance, etc.). Clinicians must weigh the benefits and drawbacks of the dressing or dressings chosen, to optimize wound healing. However, one aspect that is common to most wound dressings is the need for moisture balance to promote wound healing. To achieve this balance, an appropriate dressing must be chosen.
Evaluation of the therapeutic efficacy of active specialistic medical dressings in the treatment of decubitus - PubMed
Abstract by Michł Senejko, Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar and Aleksander Sieroń (Poland - Postepy Dermatol Alergol.).
Journal of Wound Management - Ipaper.io
The July 2021 of the Journal of Wound Management (JOWM). Official journal of the European Wound Management Association has now been published.
Result of the 2021 Council election - Ewma.org
EWMA warmly welcomes the following new or re-elected members of the EWMA Council: Elected by the individual members: Mark Collier, United Kingdom; Magdalena Annersten Gershater, Sweden; Alexandra Marques, Portugal (re-election); Andrea Pokorná, Czech Republic (re-election). Elected by the Cooperating Organisations of EWMA: Beata Gress Halasz, Slovak Wound Care Association (SSOOR).
EWMA research grants supported by Convatec - Ewma.org
EWMA and Convatec are partnering this year to support three grants available to healthcare professionals. The goal of this initiative is to support the use of new technologies in wound management and/or good communication and safety in clinical practice.
The closing date for receipt of applications is Sunday 17 October 2021.
Extracellular Vesicles in Skin Wound Healing - Mdpi.com
Article by Deimantė Narauskaitė, Gabrielė Vydmantaitė, Justina Rusteikaitė, Revathi Sampath, Akvilė Rudaitytė, Gabija Stašytė, María Isabel Aparicio Calvente and Aistė Jekabsone (Kaunas, Lithuania - Pharmaceuticals).
This review aims to promote scientific awareness in basic and translational research of extracellular vesicles by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.
Electrospun chitosan nanofibers for wound healing application - Sciencedirect.com
Article by Congjing Cui, Shibin Sun, Shaohua Wu, Shaojuan Chen, Jianwei Ma and FangZhou (Qingdao, China - Engineered Regeneration).
The present work reviews the recent studies on the design and development of electrospun chitosan nanofibers and their applications for wound healing, such as antibacterial materials, hemostatic dressings, angiogenesis and immune regulation.
A Combination of Coconut Fiber Suture and Tamarind Seed Gel with Dehydrated Human Amnion Membrane for Wound Surgery in Rats - Hindawi.com
Article by Raghu Babu Pothireddy, Angeline Julius, Manu Thomas Mathai, Ganesh Lakshmanan and Beimnet Asfaw Hailemariam (India, Ethiopia - Advances in Materials Science and Engineering).
This research signifies the use of tamarind seed polysaccharide gel together with the amnion membrane representing a “smart patch” with wound healing potential, which would encourage further research on the smart patch made using a combination of plant and animal biological materials.
Fibrillar biopolymer-based scaffolds to study macrophage-fibroblast crosstalk in wound repair - PubMed
Abstract by Franziska Ullm and Tilo Pompe (Leipzig, Germany - Biol Chem.).
Immunologic Roles of Hyaluronan in Dermal Wound Healing - Mdpi.com
Article by Aditya Kaul, Walker D. Short, Sundeep G. Keswani and Xinyi Wang (Houston, USA - Biomolecules).
This review seeks to synthesize the literature on wound healing with a focus on hyaluronic acid’s involvement in the immune subsystems.
Dasatinib induces loss of vascular integrity and promotes cutaneous wound repair in mice - PubMed
Abstract by Surasak Wichaiyo, Saovaros Svasti, Wasu Supharattanasitthi and Noppawan Phumala Morales (Thailand - J Thromb Haemost.).
Efficiency of Hyperbaric Oxygen Therapy Combined with Negative-Pressure Wound Therapy in the Treatment Strategy of Fournier's Gangrene -A Retrospective Study - PubMed
Abstract by Łukasz Michalczyk, Agnieszka Grabińska, Beata Banaczyk, Marek Braszko, Aneta Andrychowicz and Tomasz Ząbkowski (Warsaw, Poland - Urol J.).
Skin temperature and vascular attributes as early warning signs of pressure injury - PubMed
Abstract by Xiaoqiong Jiang, Xiangqing Hou, Ning Dong, Haisong Deng, Yu Wang, Xiangwei Ling, Hailei Guo, Liping Zhang and Fuman Cai (Wenzhou, China - J Tissue Viability).
Cost-effectiveness of adjunctive negative pressure wound therapy in paediatric burn care: evidence from the SONATA in C randomised controlled trial - Nature.com
Article by Cody C. Frear, Bronwyn R. Griffin, Leila Cuttle, Roy M. Kimble and Steven M. McPhail (Australia - Scientific Reports).
Findings remained robust to sensitivity analyses employing alternative theatre costs and time-to-re-epithelialisation estimates for grafted patients. In conclusion, adjunctive NPWT is likely to be a cost-effective and dominant treatment for small-area paediatric burns.
Evaluation of the wound healing activity of ethanolic extract of Bergenia ciliata (Haw.) Sternb. rhizome with excision wound model in Wistar rats - Sciencedirect.com
Abstract by Harpreet Kour, Rajinder Raina, Pawan Kumar Verma, Adil Mehraj Khan, Makhmoor Ahmad Bhat and Nawab Nashiruddullah (India - Journal of Ethnopharmacology).
The senescence-associated secretory phenotype: Fueling a wound that never heals - Sciencedirect.com
Abstract by Tanya Pulido, Michael C. Velarde and Fatouma Alimirah (USA, Philippines - Mechanisms of Ageing and Development).
Determination of wound healing activity of Shark liver oil using the excision wound model in Wistar rats - Pharmascope.org
Article by Auti S A, Jat R K, Das S K and Shukla S T (International Journal of Research in Pharmaceutical Sciences).
The biochemical biomarkers like SOD (Superoxide dismutases), GSH (Reduced Glutathione) and LPO (Lipid peroxidase) in the treated group have shown a significant change in the improvement of wound healing. Histopathological studies and microscopic observations specify that the topical use of Shark liver oil Emulgel extensively improved wound contraction, collagenation and epithelialization with well-organized dermis devoid of inflammatory cells in contrast to disease control.
The principles of maggot therapy and its role in contemporary wound care - Nursingtimes.net
There is growing evidence to support the use of maggot therapy in wound care. This article describes how maggot therapy can aid wound debridement, reduce the bacterial burden and speed up healing.
Biophotonic Treatment Accelerates Burn Wound Healing - Hospimedica.com
A new study suggests that low dose photobiomodulation (PBM) therapy can speed up recovery and reduce inflammation in third-degree burns.
At-Risk Patient: Diabetic Foot Ulcers - Woundsource.com
Patients with diabetes have a higher risk of ulceration, typically on the lower extremities. Other factors contributing to the risk of foot ulceration include peripheral neuropathy, peripheral arterial disease, infection and pressure.
Tele Wound Care Navigation for Wound Care Providers - Woundsource.com
The digital age is upon us, like it or not, ready or not. For the past few years, payers have incentivized, encouraged, reimbursed, and adopted various digital, remote monitoring systems and devices as a way to encourage providers to adopt more digital, remote methods.
Pressure injuries during the SARS-CoV-2 pandemic: A retrospective, case-control study - PubMed
Abstract by Mònica Sianes-Gallén, Anna María Pujol-García, Montserrat Rus García, Carmen Partera Luque, Montserrat López Postigo, Silvia Call Mañosa, María Carmen Camposo Montesino, Belén Ibáñez Touriño, Eulalia Ribas Obon, Tania Segura Rodríguez, Pilar Cores Fuentes, Marta Tamame Sanantonio and Montsant Jornet-Gibert (Spain - J Tissue Viability).
Photobiomodulation and diabetic foot and lower leg ulcer healing: A narrative synthesis - PubMed
Abstract by Eliana Sutton, Sharifah Ganie, Charlene Chan, Anureet Kaur and Ethne Nussbaum (Canada - Foot (Edinb).).
Bacterial bioburden of wounds: influence of debridement and negative-pressure wound therapy (NPWT) - PubMed
Abstract by Philipp Moog, Maryna Jensch, Julia Betzl, Anna-Theresa Bauer, Michael K Cerny, Daniel Schmauss, Haydar Kükrek, Holger Erne, Hans-Günther Machens and Kai Megerle (Germany, Switzerland - J Wound Care).
Our contemporary understanding of the aetiology of pressure ulcers/pressure injuries - PubMed
Abstract by Amit Gefen, David M Brienza, Janet Cuddigan, Emily Haesler and Jan Kottner (Israel, USA, Australia, Germany - Int. Wound J.).
More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing - Biomedcentral.com
Article by Qianmin Ou, Shaohan Zhang, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu, Zeyuan Cao, Jun Wu and Yan Wang (China - Journal of Nanobiotechnology).
The triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. The authors' study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration.
Clostridium Collagenase Impact on Zone of Stasis Stabilization and Transition to Healthy Tissue in Burns - Mdpi.com
Article by Rosanne E. Frederick, Robert Bearden, Aleksa Jovanovic, Nasreen Jacobson, Rajiv Sood and Sandeep Dhall (Fort Worth, USA - IJMS).
The authors' data validate the impact of clostridial collagenases in the pathophysiology of burn wounds and that they complement patient outcomes in the clinical scenario.
The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats - Mdpi.com
Article by Mongi Saoudi, Riadh Badraoui, Ahlem Chira, Mohd Saeed, Nouha Bouali, Salem Elkahoui, Jahoor M. Alam, Choumous Kallel and Abdelfattah El Feki (Tunisia, Saudi Arabia - Molecules).
The results provided that Allium subhirsutum L., particularly it's oil extract, has a potential medicinal value to act as effective skin wound healing agent.
Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing - Oup.com
Article by Alessia Ajovalasit, Carlos Redondo-Gómez, Maria Antonietta Sabatino, Babatunde O Okesola, Kristin Braun, Alvaro Mata and Clelia Dispenza (Italy, UK - Regenerative Biomaterials).
This work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular matrix.
Keratin-Alginate Sponges Support Healing of Partial-Thickness Burns - Mdpi.com
Article by Zi Kuang Moay, Luong T. H. Nguyen, Pietradewi Hartrianti, Declan P. Lunny, David Leavesley, Yee Onn Kok, Si Jack Chong, Alvin Wen Choong Chua, Shang-Ian Tee and Kee Woei Ng (Singapore, USA, Indonesia - IJMS).
Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
Effect of application of Chitosan in skin grafting surgeries in rabbits - Iop.org
Article by Hayder Mohammed Mohsen Al-Tomah, Falah Mahmood Hameed, Ali J. AL-Nuaimi and Ail Wasfi Sadeq (Karbala, Iraq - Journal of Physics).
The results showed that the chitosan-treated grafts was healed more controllable with less scar tissue than non-treated grafts which indicates that the chitosan was coordinated the healing.
MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression - PubMed
Abstract by Jing Liu, Jiahuan Wang, Wan Fu, Xiaoyi Wang, Hongxing Chen, Xiaoying Wu, Guojuan Lao, Yuxi Wu, Mengdie Hu, Chuan Yang, Li Yan and Meng Ren (Guangzhou, China - Aging (Albany NY)).
Diabetic Foot Wounds Treated With Human Amniotic Membrane and Low-level Laser Therapy: A Pilot Clinical Study - PubMed
Abstract by Joelita de Alencar F Santos, Renata A Nicolau, Luciana B Sant'Anna, Josne C Paterno, Priscila C Cristovam, Jose Álvaro P Gomes, José Diego Marques Santos and Emilia A Lo Schiavo Arisawa (Brazil, Canada - Wound Manag Prev.).
The bright side of fibroblasts: molecular signature and regenerative cues in major organs - Nature.com
Article by Rita N. Gomes, Filipa Manuel and Diana S. Nascimento (Portugal - npj Regenerative Medicine).
The authors provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. They further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype.
Current Insights into Collagen Type I - Mdpi.com
Article by Ruth Naomi, Pauzi Muhd Ridzuan and Hasnah Bahari (Malaysia - Polymers).
The review is intended to provide specific information on Col-I currently available, going back five years. This is expected to provide a helping hand for researchers who are concerned about any development on collagen-based products particularly for therapeutic fields.
Bio-inspired, blood-repelling tissue glue could seal wounds quickly - Sciencedaily.com
Engineers have designed a strong, biocompatible glue that can seal injured tissues and stop bleeding, inspired by the sticky substance that barnacles use to cling to rocks.
Molecule could light up tumor growth and wound healing - Futurity.org
Researchers have developed a molecule that lights up where new tissue is forming in the body. Alongside helping to detect tumors, the molecule could play a significant role in research of wound healing disorders.
Light Therapy Treatment Helps Burn Injuries Heal Faster - Scitechdaily.com
Light therapy may accelerate the healing of burns, according to a University at Buffalo-led study. The research, published in Scientific Reports, found that photobiomodulation therapy – a form of low-dose light therapy capable of relieving pain and promoting healing and tissue regeneration – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division.
How Will Wound Care Evolve in the Future? - Medicaltechoutlook.com
Wound care is expected to cost billions of pounds annually. Wound management products are estimated to be responsible for almost one-quarter of the costs. New approaches to woundmanagement are discussed in this chapter, along with ways in which innovation will improve patient outcomes.
Future of Bovine Amniotic Membrane: Bovine Membrane Application on Wound Healing, Surgery and Prospect of Use for Urethral Reconstruction - Intechopen.com
Article by I Gusti Bagus Adria Hariastawa and Jemmy Andijaya Sutantio.
Bovine membrane has been known to be used for many specialties such as ocular surgery, neurosurgery, maxillofacial and orthopedic surgery. This chapter includes such studies and shows the usage possibility of bovine amniotic membrane for other complex defect as shown in urethral reconstruction.
Chitosan alginate nanoparticles as a platform for the treatment of diabetic and non-diabetic pressure ulcers: formulation and in vitro/in vivo evaluation - PubMed
Abstract by Marwa M Sheir, Maha M A Nasra and Ossama Y Abdallah (Alexandria, Egypt - Int J Pharm.).
Role of Honey in Advanced Wound Care - Mdpi.com
Article by Hana Scepankova, Patricia Combarros-Fuertes, José María Fresno, María Eugenia Tornadijo, Miguel Sousa Dias, Carlos A. Pinto, Jorge A. Saraiva and Letícia M. Estevinho (Portugal, Spain - Molecules).
This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials.
Mesenchymal stromal cells in wound healing applications: role of the secretome, targeted delivery and impact on recessive dystrophic epidermolysis bullosa treatment - Sciencedirect.com
Abstract by Julia Riedl, Courtney Popp, Cindy Eide, Christen Ebens and JakubTolar (Minneapolis, USA - Cytotherapy).
Negative Pressure Wound Therapy for Improved Nipple Survival in Large Volume Reduction Mammaplasty - PubMed
Abstract by Ricardo Engel, Yitzchok Greenberg and Aamir Siddiqui (Detroit, USA - Aesthetic Plast Surg.).
Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed Lactococcus chungangensis CAU 1447 on Diabetic Mice - Mdpi.com
Article by Yohan Nam, Jonghwa Kim, Jihye Baek and Wonyong Kim (Seoul, Korea - Nutrients).
The authors' findings demonstrated that heat-killed Lactococcus chungangensis CAU 1447 had beneficial effects on wound healing and can be utilized as postbiotic therapeutic agents.
Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489-3p/Sirt1 axis - Sciencedirect.com
Abstract by Liang Huang, Hua-An Cai, Ming-Sheng Zhang, Ruo-Yi Liao, Xing Huang and Feng-Dan Huc (China -
Journal of Pharmacological Sciences).
Wound healing potential of Launaea pinnatifida Cass leaf juice in rats - Pharmascope.org
Abstract by Kamala K. Chandak and Dipak D. Wasule (Maharashtra, India - Archives).
Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing - Nature.com
Article by Xinchen Du, Le Wu, Hongyu Yan, Zhuyan Jiang, Shilin Li, Wen Li, Yanli Bai, Hongjun Wang, Zhaojun Cheng, Deling Kong, Lianyong Wang and Meifeng Zhu (Tianjin, China).
The authors demonstrate MACS' anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.
Development of Hydrogels with the Incorporation of Raphanus sativus L. Seed Extract in Sodium Alginate for Wound-Healing Application - Mdpi.com
Article by Muhammad Zahid, Maria Lodhi, Ayesha Afzal, Zulfiqar Ahmad Rehan, Muzzamil Mehmood, Talha Javed, Rubab Shabbir, Dorota Siuta, Fayez Althobaiti and Eldessoky S. Dessok (Pakistan, China, Poland, Saudi Arabia - Gels).
All seed extracts containing hydrogels showed clear curative performance as compared to the control hydrogel, whereas their healing magnitude lessened as the extract ratio decreased. It was concluded from the results of the current study that the Raphanus sativus L. plant has wound-healing characteristics.
The Combined Use of a Non-Invasive Skin-Stretching Device and the Negative-Pressure Wound Therapy Technique in the Treatment of Postoperative Diabetic Foot - Dovepress.com
Article by Liangchen Wang, Chenrui Wang, Hongmei Chen, Ying Chen, Juan Li, Li Xiao, Di Zhu and Caizhe Yang (Beijing, China - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy).
The use of the NPWT technique combined with a NSSD can shorten the wound healing time and improve the wound healing rate of DF gangrene patients during the postoperative wound repair period.
NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence - Nature.com
Article by Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Annette Audigé, Khanh Huỳnh, Julian Zacharjasz, Julien Debbache, Yann Kerdiles, Dagmar Gotthardt, Norihiko Takeda, Joachim Fandrey, Lukas Sommer, Veronika Sexl and Christian Stockmann (Switzerland, France, Austria, Japan, Germany).
The authors demonstrate that mice lacking the Hypoxia-inducible factor (HIF)-1α isoform in NK cells show impaired release of the cytokines Interferon (IFN)-γ and Granulocyte Macrophage - Colony Stimulating Factor (GM-CSF) as part of a blunted immune response. This accelerates skin angiogenesis and wound healing.
Chitosan-Coated Poly(lactic acid) Nanofibres Loaded with Essential Oils for Wound Healing - Mdpi.com
Article by Giulia Milanesi, Barbara Vigani, Silvia Rossi, Giuseppina Sandri and Elisa Mele (Italy, UK - Polymers).
The results obtained proved that the CS coating improved the hydrophilicity of the fibrous mats, enhanced EO’s antibacterial potential, and promoted cell adhesion and proliferation.
Berberine Encapsulated Lecithin–Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes - Mdpi.com
Article by Dibya Sundar Panda, Hussein M. Eid, Mohammed H. Elkomy, Ahmed Khames, Randa M. Hassan, Fatma I. Abo El-Ela and Heba A. Yassin (Saudi Arabia, Egypt - Pharmaceutics).
Based on the experimental results, lecithin–chitosan nanoparticles loaded with berberine have evolved as a promising strategy for accelerating wound the healing process in diabetic patients.
Medicinal Plants as Efficacious Agents for Diabetic Foot Ulcers: A Systematic Review of Clinical Studies - Hmpgloballearningnetwork.com
Article by Roohollah Ahmadian, Roodabeh Bahramsoltani, André M Marques, Roja Rahimi and Mohammad Hosein Farzaei (Iran).
Per the studies included in this review, medicinal plants can be recommended as promising adjuvant therapies to conventional wound care to accelerate wound healing in patients with DFUs.
Understanding the Braden Scale: Focus on Sensory Perception (Part 1) - Woundsource.com
Article by Holly Hovan.
As wound care professionals, the Braden Scale for Predicting Pressure Sore Risk® is near and dear to our hearts. With that in mind, our evidence-based tool needs to be used correctly to yield accurate results. Working with long-term care and geriatric populations opens up a world of multiple pre-existing comorbidities and risk factors that aren’t always explicitly written into the Braden Scale categories. Additionally, the frequency of Braden Scale use may contribute to a multitude of different scores.
Topical Ointment for Management of Infected Wounds - Researchsquare.com
Article by Rajashekharayya A. Sanguramath, Boaz Laadan and Ariel Franco.
The ointment prepared by the authors showed very high killing efficacy against a spectrum of bacteria ( ̴6Log reduction) and a pathogenic yeast ( ̴5Log reduction) within 2h of exposure. Results described here would be of great benefit to professionals as wells as for personal use in treating infected wounds.
β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling - PubMed
Abstract by Xiao Yang, Weijing Fan, Renyan Huang and Guobin Liu (Shanghai, China - Cell Mol Biol Lett.).
Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action - PubMed
Abstract by Mikaella T B Carvalho, Heitor G Araújo-Filho, André S Barreto, Lucindo J Quintans-Júnior, Jullyana S S Quintans and Rosana S S Barreto (São Cristóvão, Brazil - Phytomedicine).
Optimal Fluence and Duration of Low-Level Laser Therapy for Efficient Wound Healing in Mice - Nih.gov
Article by Jisun Yoon, Ji Hyun Park, Jee-Woong Choi and You Chan Kim (Suwon, Korea - Ann Dermatol.).
The authors have shown that repeated exposure to low levels of light significantly stimulates wound healing in mice and demonstrated more efficient wound closure with certain fluences of 830 nm irradiation.
The Role of Free Tissue Transfers for Defect Coverage over the Body in Geriatric Populations - Mdpi.com
Article by Elif Kulakli-Inceleme, Matthias Knobe, Elmar Fritsche and Mario F. Scaglioni (Lucerne, Switzerland - Medicina).
In cases where a free flap procedure is needed, infections should be treated properly, and vascular status and coagulation should be optimized before performing a free flap procedure.
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine - Mdpi.com
Article by Mangesh D. Hade, Caitlin N. Suire and Zucai Suo (Tallahassee, USA - Cells).
In this review, the authors summarize the current knowledge of exosome biogenesis, composition, and isolation methods. They also discuss emerging healing properties of exosomes and exosomal cargos, such as microRNAs, in brain injuries, cardiovascular disease, and COVID-19 amongst others.
Customized, biomedically applicable materials based on tropoelastin for wound care - News-medical.net
Customized, biomedically applicable materials based on tropoelastin are being developed in a joint project by Skinomics GmbH from Halle, Martin Luther University Halle-Wittenberg and the Fraunhofer Institute for Microstructure of Materials and Systems IMWS. The material combines biocompatibility, durability, biodegradability and favorable mechanical properties similar to those of skin. Preclinical tests have confirmed that it is suitable for use as a wound dressing material used in the treatment of chronic and complex wounds.
Calcified leg Ulcers in older patients: clinical description, morphology and chemical characterization - PubMed
Abstract by Hester Colboc, Juliette Fontaine, Dominique Bazin, Vincent Frochot, Emmanuel Letavernier, Michel Daudon, Naomi Laporte, Stéphan Rouzière, Michael Reby, Agnes Galezowski, Christine Forasassi and Sylvie Meaume (France - J Gerontol A Biol Sci Med Sci.).
Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed Lactococcus chungangensis CAU 1447 on Diabetic Mice - Mdpi.com
Article by Yo Han Nam, Jong-Hwa Kim, Jihye Baek and Wonyong Kim (Seoul, Korea - Nutrients).
The authors' findings demonstrated that heat-killed Lactococcus chungangensis CAU 1447 had beneficial effects on wound healing and can be utilized as postbiotic therapeutic agents.
Development of dual crosslinked mumio-based hydrogel dressing for wound healing application: Physico-chemistry and antimicrobial activity - Mdpi.com
Abstract by Oyunchimeg Zandraa, Fahanwi Asabuwa Ngwabebhoh, Rahul Patwa, Hau Trung Nguyen, Marjan Motiei, Nabanita Saha, Tomas Saha and Petr Saha (Zlin, Czech Republic - Int J Pharm.).
Comparison of clinical outcomes of lower extremity burns in diabetic and non-diabetic patients: a retrospective analysis - Mdpi.com
Abstract by Sydney Rotman, Pierre Lapaine, Sarah Rehou, Marc G Jeschke and Shahriar Shahrokhi (Toronto, Canada - J Burn Care Res.).
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