Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression - Wiley.com
Article by Shola Michelle Richards, Caroline Gubser Keller, Robert Kreutzer, Géraldine Greiner, Svenja Ley et al. (Basel, Switzerland - International Wound Journal).
The identified diagnostic markers hold the potential to enhance preclinical and clinical trials in the field of wound healing.
The impact of psychological interventions on surgical site wound healing post-surgery in psoriasis patients: A meta-analysis - Wiley.com
Article by Na Wang, Lin Pei, Mengqian Zhang, Gang Wang, Shumao Zheng et al. (Shijiazhuang, China - International Wound Journal).
The authors' results highlight the beneficial role of psychological support in the postoperative recovery of psoriasis patients, suggesting a need for a more integrated approach to patient care that includes psychological well-being as a component of comprehensive treatment strategies.
Development and biological evaluation of smart powder bandage for wound healing and dressing applications - Sciencedirect.com
Abstract by Suryanarayana Polaka, Bhakti Pawar, Nupur Vasdev and Rakesh Kumar Tekade (Gandhinagar, India - International Journal of Biological Macromolecules).
Wound healing after therapy of oral potentially malignant disorders with a 445-nm semiconductor laser: a randomized clinical trial - Springer.com
Article by Axel Meisgeier, Paul Heymann, Thomas Ziebart, Andreas Braun and Andreas Neff (Germany - Clinical Oral Investigations).
Laser coagulation of oral potentially malignant disorders with the investigated 445-nm semiconductor laser is a safe, gentle, and predictable surgical procedure with beneficial wound healing and reduced postoperative discomfort.
A Randomized Controlled Trial Comparing Two Wound Dressings Used in Obstetric and Gynecological Surgeries: Trushield NXT vs. Tegaderm - PubMed
Abstract by Prema D Cunha and Prathima Gowda (Mangaluru, India - Cureus).
Performance and safety assessment of materials used in the medical devices destinated for pressure ulcer management - PubMed
Abstract by Abdullah Mouchati and Najet Yagoubi (France - J Tissue Viability).
Mesenchymal Stromal Cell Healing Outcomes in Clinical and Pre-Clinical Models to Treat Pressure Ulcers: A Systematic Review - PubMed
Abstract by Ricardo A Torres-Guzman, Francisco R Avila, Karla Maita, John P Garcia et al. (Jacksonville, USA - J Clin Med.).
Vitamin D Deficiency Is Associated with Increased Length of Stay After Acute Burn Injury: A Multicenter Analysis - PubMed
Abstract by Sarah Zavala, Kate O Pape, Todd A Walroth, Melissa Reger, Brittany Hoyte et al. (USA - J Burn Care Res.).
Natural hydrogel dressings in wound care: Design, advances, and perspectives - Sciencedirect.com
Article by Xiaoliu Liang, Chunliu Huang, Hui Liu, Hu Chen, Jiabao Shou, Hongwei Cheng and Gang Liu (China - Chinese Chemical Letters).
This review offers a comprehensive overview of the current state and potential future advancements in natural hydrogel dressings for wound care, highlighting their critical role in addressing complex and hard-to-heal wounds.
Vulnerability to Decubitus Ulcers and Their Association With Healthcare Utilization: Evidence From Nationwide Inpatient Sample Dataset From 2016 to 2020 in US Hospitals - PubMed
Abstract by Sun Jung Kim, Mar Medina, Kaci Hotz, Juliy Kim and Jongwha Chang (USA - J Patient Saf.).
Understanding the link between primary cilia, biological clock and wound healing - News-medical.net
Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell's clock genes, which do exactly as you suspect from the name: regulate your body's rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia's potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.
Clearing the debris - Elifesciences.org
Single-cell RNA sequencing sheds new light on how immune cells remove dead cells from wounds in mice and humans.
The Use of Hyperbaric Oxygen Therapy in the Treatment of Hand Crush Injuries - PubMed
Abstract by Dun-Hao Chang, Chi-Ying Hsieh, Che-Wei Chang, Hsu-Hui Wang and Hou-Tai Chang (Taiwan - Wound Repair Regen.).
Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats - Springer.com
Article by Kyriakos Chatzimisios, Vassiliki Tsioli, Georgia D. Brellou, Emmanouela P. Apostolopoulou et al. (Greece, The Netherlands - Animals).
Topical application of medical-grade honey or Hypericum did not accelerate the healing process of feline cutaneous wounds.
Chitosan in Wound Healing: a Mini Review on Ethical Perspective on Sustainable and Biomedical Biomaterials - Springer.com
Abstract by Yerraboina Praneeth, Komal, Inderpal Devgon, Rohan Samir Kumar Sachan et al. (India - Regenerative Engineering and Translational Medicine).
Targeting Signalling Pathways in Chronic Wound Healing - Mdpi.com
Article by Lian Bonnici, Sherif Suleiman, Pierre Schembri-Wismayer and Analisse Cassar (Msida, Malta - IJMS).
In this review, the current research on targeting signalling pathways under chronic wound conditions will be discussed together with implications for future studies.
Advanced function, design and application of skin substitutes for skin regeneration - Sciencedirect.com
Article by Miao Zhang, Jiyao Xing, Yingjie Zhong, Tingting Zhang, Xinlin Liu and Dongming Xing (China - Materials Today Bio).
This review introduces currently available skin substitutes in clinical trials and on the market and the related regulatory requirements. The prospects and challenges of skin substitutes in the field of tissue engineering are discussed.
Impact of preoperative chemotherapy on cutaneous wound healing in lung cancer patients: A meta-analysis - PubMed
Abstract by Jialai Zhao, Hanwen Cui, Mingyue Qu, Zigeng Xu, Yiling Zhang and Chenguang Ma (Harbin, China - Int Wound J.).
Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines - Mdpi.com
Article by Sławomir Lewicki, Michał Zwoliński, Adrian Hovagimyan, Marta Stelmasiak et al. (Poland, USA - IJMS).
The authors' freeze-drying approach enables the storage of G-CSF or GM-CSF enriched dressings at 24 °C with minimal cytokine loss, preserving their biological activity and thus enhancing future clinical availability.
Enhanced antibacterial activity of wound dressings based on alginate/hydroxyapatite modified with copper and naproxen - Springer.com
Abstract by Marcela P. Bernardo, Daniel Pasquini and Luiz H. C. Mattoso (Brazil - Journal of Materials Research).
MRSA: The Basics - Woundsource.com
Article by Cathy L. Harmon.
Staphylococcus aureus, or "staph" bacteria normally reside on the skin and nose and is usually harmless. Most individuals do not manifest any symptoms of illness; however due to its prevalence, this pathogen is a common culprit of hospital-acquired infection.
Incontinence-Associated Dermatitis: Evidence-Based Practices - Woundsource.com
Article by Holly M. Hovan.
Moisture-associated skin damage (MASD) is sometimes accompanied by serous exudate, a denuded appearance of skin, or a secondary cutaneous infection. As the most common form of MASD, incontinence-associated dermatitis (IAD) is characterized by erythema and edema of the skin’s surface. IAD is a top-down injury, often presenting with inflammation, erosion, or denudation in the setting of fecal or urinary incontinence.
A Novel Comprehensive Therapeutic Approach to the Challenges of Chronic Wounds: A Brief Review and Clinical Experience Report - Springer.com
Article by Griscom Bettle III, Desmond P. Bell and Suzanne J. Bakewell (Sarasota, USA - Advances in Therapy).
Clinical trials evaluating the OCM (complete matrix) formulation as part of the comprehensive treatment regimen of multiple wound types are underway.
Physical healing as a function of perceived time - Nature.com
Article by Peter Aungle and Ellen Langer (Cambridge, USA - Scientific Reports).
The authors' results support the hypothesis that the effect of time on physical healing is directly affected by one’s psychological experience of time, independent of the actual elapsed time.
Treating Chronic Wounds in an Acute Care Setting: The Forgotten Diagnosis - Hmpgloballearningnetwork.com
Article by Emily Sue Greenstein, William Falone, Teresa Patterson, Katherine Cesario et al. (USA).
Hospitals can play a key role in the management of chronic wounds, thus reducing the effect on each facility and the wider care network. The effect of chronic wounds on acute care facilities can be significant and can include unseen costs that often are absorbed by reimbursement for separate primary diagnosis, the use of 25% to 40% of hospital beds by patients requiring some form of wound management, demands on bedside nurses with limited time or knowledge to provide adequate wound care, and the risk of wound complications that could lead to longer stays or readmissions.
A brief note on stages of wound healing - Alliedacademies.org
Article by Maria Witte (Miami, USA - Journal of Dermatology Research and Skin Care).
This article provides a comprehensive overview of the four stages of wound healing, hemostasis, inflammation, proliferation, and remodeling. Each stage involves specific cellular and biochemical activities that contribute to the successful closure and recovery of wounds.
The cellular players that enable wound healing - Drugdiscoverynews.com
Article by Luisa Torres.
A coordinated effort between the stroma, the immune system, and the skin microbiome restores damaged skin.
International collaboration in wound care to protect lives worldwide - Schuelke.com
The use of antiseptics plays an important role in the fight against antimicrobial resistance (AMR) and multidrug-resistant bacteria that act as one of the main opponents to wound healing. The consensus is to provide guidance for clinicians.
Organizing collective cell migration through guidance by followers - PubMed
Abstract by Arthur Boutillon (France - C R Biol.).
Pressure Injuries: What to Do When Surgery Fails - Generalsurgerynews.com
Article by Chase Doyle.
Advanced-stage pressure injuries, or pressure ulcers, are a difficult and increasingly common problem whose challenges persist long after the completion of surgery. Meticulous postoperative care and timely management of complications are critical to a successful outcome.
Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin - Mdpi.com
Article by Fatima Errajouani, Hanane Bakrim, Sohaib Hourfane, Adnane Louajri et al. (Morocco, Portugal - Cosmetics).
The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively).
Innovative biochemisurgical treatment for stabilisation of an end-stage chronic wound in a complex vascular compromized patient - Sciencedirect.com
Article by A. Algharib, L.M.C. van Dortmont, R. Hendrix, S. Riedel, R. Möller and G. G. Koning (Nordhorn, Germany - International Journal of Surgery Case Reports).
The goal of achieving a secondary healing trend is to establish stability within the wound area or achieve complete healing. This endeavor becomes particularly intricate when severe blood circulation compromise exists.
A flexible adhesive hydrogel dressing of embedded structure with pro-angiogenesis activity for wound repair at moving parts inspired by commercial adhesive bandages - Sciencedirect.com
Article by Xingling Jian, Huajun Wang, Xingming Jian, Yanfen Zou, Bin Jiang et al. (China - Materialstoday).
The biocompatible flexible and adhesive hydrogel dressing with pro-angiogenesis activity shows strong potential in wound tissue remodeling, providing a new strategy for the treatment of moving parts or sensitive wound parts.
Efficacy of prophylactic negative pressure wound therapy after open ventral hernia repair: a systematic review meta-analysis - Wiley.com
Abstract by Yang Xu, Shuai Shao, ZeZhong Gong, HyokJu Ri, ZhaoHui Xu, HaoNan Kang et al. (China, Korea - BMC Surg.).
The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds - Cureus.com
Article by Melanie Wilson (Jacksonville, USA).
The study found that the synthetic matrix was effective, resulting in improved healing across various etiologies, including cancer resection and amputation.
Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn - PubMed
Abstract by Christian Oktavianus Manginstar, Trina Ekawati Tallei et al. (Indonesia - Phytotherapy Research)
Negative pressure wound therapy for complex oral wounds - PubMed
Abstract by Mykaihla Sternick, James C Gates, Allen Champion and Andrew Yampolsky (Philadelphia, USA - J Surg Case Rep.).
Uniform Selection And Representation Matching: A Framework For Classifying Wound Healing Stage - PubMed
Abstract by Michael Briden and Narges Norouzi (Annu Int Conf IEEE Eng Med Biol Soc.).
Edema and Micronized Purified Flavonoid Fraction: What the Evidence Says - Woundsource.com
Article by Laura Swoboda.
Lower extremity edema is a common comorbidity in wound patients with varying associated etiologies and contributing factors. While compression is the gold standard for managing edema, optimizing treatment for patients with phlebolymphedema often involves more than just compression.
Ballistic Wounds: Battlefield Healing History - Woundsource.com
Article by Christine Miller.
Ballistic wounds are those attributed to trauma from firearms. Worldwide, these injuries resulted in approximately 270,000 deaths in 2016 alone. With the impact and care of these wounds in mind, an understanding of how certain practices arose can put into perspective how care is delivered today.
Efficacy of the combination of Chinese herbal medicine and negative pressure wound therapy in the treatment of patients with diabetic foot ulcer: A meta-analysis - PubMed
Abstract by Jin Li, Hong-Yu Wang, Yu-Feng Yang, An-Na Wang, Yan Shi and Ting-Bao Cui (Liaoning, China - Int Wound J.).
Wound Microbiota and Its Impact on Wound Healing - Mdpi.com
Article by Małgorzata Zielińska, Agnieszka Pawłowska, Anna Orzeł, Luiza Sulej et al. (Poland - IJMS).
Determining the ideal microbiota composition for optimal wound healing, elucidating precise influence mechanisms, devising effective manipulation strategies, and comprehending the intricate interplay between the microbiota, host, and other factors require further exploration.
Meta‐analysis of minimally invasive arthroscopy with sodium hyaluronate for wound healing of knee osteoarthritis treatment in the elderly - Wiley.com
Article by Fujie Zhang, Jinlei Zhang and Tengyun Wang (Weifang, China - International Wound Journal).
The authors' results support the use of this combined approach in the management of KOA in the elderly population and emphasize the need for additional research to optimize treatment protocols and comprehend long-term outcomes.
Recent advances on 3D-bioprinted gelatin methacrylate hydrogels for tissue engineering in wound healing: A review of current applications and future prospects - Wiley.com
Article by Hongyu Wang, Jiaming Wan, Zhiqiang Zhang and Ruixing Hou (China - International Wound Journal).
The review covers gelatin methacrylate"s (GelMA's) applications from enhancing wound dressings, promoting angiogenesis and facilitating tissue regeneration to addressing microbial infections and diabetic wound healing. Preclinical studies underscore GelMA's potential in tissue healing and the need for further research for real-world applications.
Impact of a High-Fat Diet at a Young Age on Wound Healing in Mice - Mdpi.com
Article by Kevin Arnke, Pablo Pfister, Gregory Reid, Mauro Vasella, Tim Ruhl et al. (Switzerland, Germany - IJMS).
The authors' findings support that an early exposition to high-fat diet resulted in juvenile obesity in mice with impaired wound repair mechanisms, which may be used as a murine model for obesity-related studies in the future.
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy - Nature.com
Abstract by Zhen Lin, Lu-yao Li, Lu Chen, Chen Jin, Yue Li, Lan Yang, Chang-zhou Li et al. (USA, Korea, China - Acta Pharmacologica Sinica).
Reproducible strategy for excisional skin-wound-healing studies in mice - Springernature.com
Abstract by Matan Yampolsky, Ido Bachelet and Yaron Fuchs (Rehovot, Israel - Nature Protocols).
Hard-to-Heal Wound Healing: Superiority of Hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a Standard Hydrogel. A Randomized Controlled Trial - Mdpi.com
Article by José Verdú-Soriano, Antonio Casado-Díaz, Marisol de Cristino-Espinar, Silvia Luna-Morales et al. (Spain - Gels).
The authors' results support the use of EHO-85 dressing, for treatment of hard-to-heal ulcers.
Intelligent wound dressing for simultaneous in situ detection and elimination of pathogenic bacteria - Sciencedirect.com
Article by Jianmin Yang, Yuxiang He, Zhendong Li, Xudong Yang, Yueming Gao et al. (China, Japan - Acta Biomaterialia).
The authors' results suggest that the proposed intelligent wound dressing has potential for use in the diagnosis and management of wound infections.
Understanding and Preventing Medical Device-Related Pressure Injury - PubMed
In this interview, Kelly McFee discusses what equipment may cause device-related pressure injury (DRPI), primary factors for DRPI development, prevention methods, assessment tips, and other tools and strategies clinicians can employ in their practice.
WHS Guidelines for the Treatment of Pressure Ulcers - 2023 update - PubMed
Abstract by Lisa J Gould, Jenny Alderden, Rummana Aslam, Adrian Barbul, Kath M Bogie et al. (USA, Egypt - Wound Repair Regen.).
Academic-Practice Partnership to Prevent and Manage Pressure Injuries: An Evidence-Based Quality Improvement Initiative - PubMed
Abstract by Jo Ann Otts, Joyce Pittman, Bettina Riley, Lisa Mestas and Heather Hall (Mobile, USA - J Wound Ostomy Continence Nurs.).
Quality of evidence supporting the role of hyperbaric oxygen therapy for diabetic foot ulcers - Wiley.com
Article by Fuxin Jiang, Yalan Zhang, Shijin Cheng, Xiaohui Yang, Min Bai and Ming Zhang (China - International Wound Journal).
The majority of outcomes had low- to moderate-quality evidence, and no high-quality evidence was found to support the role of HBOT for DFUs, according to GRADE. To conclude, the potential of HBOT in treating DFUs is supported by evidence of low to moderate quality.
Clinimetrics of the Lanarkshire Oximetry Index for patients with leg ulcers: A systematic review and meta-analysis - Wiley.com
Article by Matthew Wynn, Melanie Stephens, Sheba Pradeep, Alexandra M. Clarke-Cornwell and Janice Bianchi (UK - International Wound Journal).
Given the relatively low specificity of the Lanarkshire Oximetry Index, it may be beneficial to combine measurement of the LOI with a subjective clinical risk assessment tool to improve the sensitivity of this alternative approach to vascular assessment.
Dysregulated wound healing in the pathogenesis of urogynecologic mesh complications - Nature.com
Article by Amanda M. Artsen, Rui Liang, Leslie Meyn, Megan S. Bradley and Pamela A. Moalli (Pittsburgh, USA - Scientific Reports).
The authors' data provide evidence of dysregulated wound healing in mesh complications. Modifiable factors provide potential targets for patient counseling and interventions.
Fish Skin Grafts Affect Adenosine and Methionine Metabolism during Burn Wound Healing - Mdpi.com
Article by Aristotelis Kotronoulas, Adrián López García de Lomana, Helga Kristín Einarsdóttir, Hilmar Kjartansson, Randolph Stone and Óttar Rolfsson (Iceland, USA - Antioxidants).
The authors' results conclusively contribute to the understanding of the multifactorial mechanism of the action of AFSG that has traditionally been attributed to its structural properties and omega-3 fatty acid content.
Current Biomaterials for Wound Healing - Mdpi.com
Article by Mauricio Downer, Charlotte E. Berry, Jennifer B. Parker, Lionel Kameni and Michelle Griffin (Stanford, USA - Bioengineering).
Biomaterials used for wound healing may be natural, synthetic, or a combination of both. Once a specific biomaterial is selected, it acts as a scaffold for skin regeneration. When the scaffold is applied to a wound, it allows for the upregulation of distinct molecular signaling pathways important for skin repair.
Predicted factors of surgical site infection in glioblastoma patients: A meta-analysis - Wiley.com
Article by Zhaowen Gu, Qiangwei Wang, Jiarui Chen and Yongjian Zhu (Hangzhou, China - International Wound Journal).
Occurrence of surgical site infection (SSI) is influenced by a variety of factors. Thus, we should pay close attention to high-risk subjects and take crucial targeted interventions to lower the SSI risk following craniotomy.
Effect of drain placement in short-level spinal surgery on postoperative wound infection: A meta-analysis - Wiley.com
Article by Baoming Zhan, Shiqiang Fang, Xiuhong Lv, Xuesheng Xie and Xing Wang (Jinan, China - International Wound Journal).
Placing drainage in short-levels of spine operation did not significantly influence the outcome of postoperative wound complications. Nevertheless, because of the limited sample size chosen for this meta-analysis, caution should be exercised when treating these data.
What Do We Truly Know About Nutritional Intervention for DFU? - Hmpgloballearningnetwork.com
Article by Jennifer Spector.
Nutrition plays a role in wound healing in the greater body of literature. The literature in DFU is lacking for convincing evidence. Current literature shows changes in surrogate markers, but healed wounds were either not evaluated or not significant.
Multicenter parallel randomized trial evaluating incisional negative pressure wound therapy for the prevention of surgical site infection after lower extremity bypass - PubMed
Abstract by Francis Rezk, Håkan Åstrand, Robert Svensson-Björk, Julien Hasselmann, Johan Nyman et al. (Sweden - J Vasc Surg.).
Risk factors predicting hospital-acquired pressure injury in adult patients: An overview of reviews - PubMed
Abstract by Isabel Wang, Rachel M Walker, Brigid M Gillespie, Ian Scott et al. (Australia - Int J Nurs Stud.)
Robots Made from Human Cells Can Move on Their Own and Heal Wounds - Scientificamerican.com
Article by Philip Ball.
Researchers have created “anthrobots” out of human lung cells that are capable of moving independently and even healing damaged tissue.
Evaluating Gelatin-Based Films with Graphene Nanoparticles for Wound Healing Applications - Mdpi.com
Article by Piotr Kamedulski, Marcin Wekwejt, Lidia Zasada, Anna Ronowska, Anna Michno et al. (Poland - Nanomaterials).
The authors found that the addition of graphene nanoplatelets had a significant effect on the properties of materials, improving surface roughness, surface free energy, antioxidant activity, tensile strength, and Young’s modulus. For the most favorable candidate for wound dressing applications, they chose a gelatin film containing nanoparticles with a surface area of 500 m2/g.
New insights into biomaterials for wound dressings and care: Challenges and trends - Sciencedirect.com
Abstract by Tatianne Dias Moreira, Vaniele Bugoni Martins, Afonso Henrique da Silva Júnior et al. (Florianópolis, Brazil - Progress in Organic Coatings).
Conducting a Biomechanical Exam As Part of Pressure Injury Prevention - Woundsource.com
Pressure injuries often result from sustained pressure and shear on skin and local tissue. As a result, patient position, posture, and load bearing are integral factors to consider to alleviate such forces. A better understanding of the biomechanics of these factors may assist clinicians and scientists in identifying and addressing biomechanical risk factors for pressure injury.
Innovation by Design: Adhesion Properties of New ConvaFoam™ - Hmpgloballearningnetwork.com
Choosing a dressing can be challenging. Clinicians don’t have time to be overwhelmed by the choice of dressing or let down by its performance. So, Convatec invested in research and development to truly understand what patients, carers, and healthcare professionals need.
Incidence, characteristics, and associated factors of pressure injuries acquired in intensive care units over a 12-month period: A secondary analysis of a quality improvement project - Hmpgloballearningnetwork.com
Abstract by Øystein Øygarden Flæten, Siv K Stafseth, Hilde Vinje, Edda Johansen, Kjetil Sunde et al. (Norway, Belgium - Intensive Crit Care Nurs.).
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