Hungarian Wound Care Society

IRF7 and CTSS are pivotal for cutaneous wound healing and may serve as therapeutic targets - Nature.com
Article by Jiali Yin, Dongxin Shi, Yan Sun, Peiyao Zhu, Yiping Zhao, Xuegang Xu, Hongduo Chen, Yan Wu, Zhengwei Yuan and Xing-Hua Gao (China - Signal Transduction and Targeted Therapy). The authors' finding confirmed their conjecture that overexpression of IRF7 and CTSS may be critical factors in the formation of keloids. They acknowledge that as keloid do not often result from excisional wounds which was studied in the mouse model. Study on human hypertrophic scar is necessary, albeit it poses difficulties in obtaining clinical samples.

Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study - Mdpi.com
Article by Zeba A. Syed, Tatyana Milman, Jolanta Fertala, Andrzej Steplewski and Andrzej Fertala (Philadelphia, USA - IJMS). This pilot study provides a stepping stone for future tests of therapeutic approaches that target corneal extracellular scar matrix assembly.

Technical Evaluation of a New Medical Device Based on Rigenase in the Treatment of Chronic Skin Lesions - Mdpi.com
Article by Eugenia Romano, Claudio Campagnuolo, Roberta Palladino, Giulia Schiavo, Barbara Maglione, Cristina Luceri and Natascia Mennini (Italy - Bioengineering). The authors investigate the technical properties of a novel advanced non-woven triple layer gauze imbibed with a cream containing Rigenase, an aqueous extract of Triticum vulgare used for the treatment of skin injuries.

Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae) - Hindawi.com
Article by Nia Yuniarsih, Himyatul Hidayah, Neni Sri Gunarti, Anggun Hari Kusumawati, Farhamzah Farhamzah, Asman Sadino and Maulana Yusuf Alkandahri (Indonesia - Advances in Pharmacological and Pharmaceutical Sciences). S. trifasciata leaves extract has the potential to be developed as a wound-healing drug derived from herbal plants formulated into hydrogel preparations.

Smartphone-based imaging reveals a breakthrough in identifying infected wounds - New-medical.net
Article by Priyom Bose. A recent Frontiers in Medicine study assesses the effectiveness of hyperspectral imaging (HSI) to identify differences between infected and non-infected wounds.

Pyoderma gangrenosum after surgery for forefoot deformity in a patient with rheumatoid arthritis: a case report - PubMed
Abstract by Yu Mori, Takuya Izumiyama, Kazuaki Otsuka, Ryuichi Kanabuchi, Jun Yamamoto, Mana Sekine, Naoko Mori, Yoshihide Asano and Toshimi Aizawa (Japan - Mod Rheumatol Case Rep.).

A Novel Wound Therapy Modality: Autologous Wound Edge Dotted Full-Thickness Skin Grafting Improving Diabetic Foot Ulcer Healing - Dovepress.com
Article by Jianhao Huang, Jingxia Sun, Qiu Wang, Jianming Mo, Yuechou Nong, Zhenwei Zhai, Xiuxian Huang, Jiacheng Mo and Wensheng Lu (China - International Journal of General Medicine). Autologous wound edge dotted full-thickness skin grafting has a higher cost-performance ratio than traditional diabetic foot ulcer wound care and is worthy of further clinical application.

Evolution of the Chronic Venous Leg Ulcer Microenvironment and Its Impact on Medical Devices and Wound Care Therapies - Mdpi.com
Article by Gisele Abreu Coelho, Philippe-Henri Secretan, Lionel Tortolano, Loïc Charvet and Najet Yagoubi (France - JCM). The main aim of this review is to identify and discuss the different stages of chronic wound progression, focusing on the changes in the biochemical composition of the wound microenvironment, with particular attention given to venous leg ulcers (VLUs), as they are one of the most prevalent chronic wound aetiologies.

Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing - Mdpi.com
Article by Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, María Dolores Carmona-Luque, Gabriel Dorado, Miriam Berenguer-Pérez, José Manuel Quesada-Gómez, María Ángeles Gálvez-Moreno and Antonio Casado-Díaz (Spain - IJMS). The authors' results, together with previous data on the effects of this hydrogel on ulcer healing in humans, indicate that EHO-85 is a suitable, low-cost, and efficient therapeutic option for wound healing.

Slough: What Is This Stuff? - Woundsource.com
Article by Dianne Rudolph. Nonviable tissue in the wound bed can be divided into 2 broad categories: slough and eschar. Although these terms are sometimes used interchangeably, it is vital to distinguish between them as they may require different management methods.

The Basics of Caring for a Patient With An Ostomy - Woundsource.com
In this interview, Erin Testerman-Mitra, BSN, RN, CWOCN discusses ways to help ostomy patients, including pre-operative measures, when convexity is right for the patient, and patient quality of life.

Self-care treatment for lymphoedema of lymphatic filariasis using integrative medicine - PubMed
Abstract by Saravu R Narahari, Madhur G Aggithaya, Terence J Ryan, Kunnathody Muralidharan, Peter J Franks, Christine Moffatt and Peter S Mortimer (India, UK - Br J Dermatol.).

The cellular players that enable wound healing - Drugdiscoverynews.com
Article by Luisa Torres. A coordinated effort between the stroma, the immune system, and the skin microbiome restores damaged skin.

New smartphone-based device can quickly identify infected wounds - News-medical.net
Article by Luisa Torres. Infection can stall healing or spread into the body if it isn’t treated quickly, putting a patient’s health in grave danger. An international team of scientists and clinicians thinks they have the solution: a device run from a smartphone or tablet app which allows advanced imaging of a wound to identify infection.

An Automatic Wound Detection System Empowered by Deep Learning - Iop.org
Article by Muhammad Adnan, Muhammad Asif, Maaz Bin Ahmad, Toqeer Mahmood, Khalid Masood, Rehan Ashraf and C.M. Nadeem Faisal (Pakistan - Journal of Physics). In this work, anautomatic wound detection technique using YOLO v3 model is proposed. The proposedtechnique detects, localizes and classifies the wound into four main categories containingstitch-wound, cut-wound, open-wound and normal-skin. The experimental results showthat theproposed technique is more efficient and robust with 99% accuracy and outperforms other counter parts.

Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds - Mdpi.com
Article by Jessica Salvo, Cristian Sandoval, Carolina Schencke, Francisca Acevedo and Mariano del Sol (Temuco, Chile - Pharmaceutics). The authors' results suggest that the nanofunctionalized Ulmoplus® with copper (Ulmoplus® + CuNPs) has synergistic effects on the production of dermal collagen fibers probably due to the lipids, carbohydrates, proteins, vitamins, amino acids, and minerals of honey; and the lipid peroxidation, protein oxidation, and DNA damage in various bacteria.

A prospective study on the efficacy of sequential treatment of technology Lipido-Colloid Impregnated with Silver and Technology Lipido-Colloid Nano-Oligosaccharide Factor in the management of venous leg ulcers - Mdpi.com
Article by Natalie Shi Qi Wong, Audrey Hui Min Tan, Kai Siang Chan, Karine C. C. Goh, Peiting Lai, Sivakami Muthuveerappa, Mohamed Maliki Bin Mohamed Nasir, Shanying Liang, Qiantai Hong, Enming Yong and Zhiwen Joseph Lo (Singapore - Health Science Reports). Sequential therapy with TLC-Ag followed by TLC-NOSF and 2LB is feasible, with good wound healing and improvement in QOL of patients with VLUs.

Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria - PubMed
Abstract by Claudio Neidhöfer, Derick Lekealem Nkwetta, Bangsi Rose Fuen, Njodzeka Flora Yenban, Nancielle Mbiatong, Gordon Takop Nchanji, Patricia Korir et al. (Germany, Cameroon - Sci Rep.).

Home-based oxygen therapy shows promise for improving wound healing after breast reduction surgery - News-medical.net
In the last few years, breast reduction procedures in the U.S. have become increasingly common. According to the American Society of Plastic Surgeons, nearly 100,000 breast reduction procedures were performed in 2020.

Characterization and Classification In Silico of Peptides with Dual Activity (Antimicrobial and Wound Healing) - Mdpi.com
Article by María Trejos, Yesid Aristizabal, Alberto Aragón-Muriel, José Oñate-Garzón and Yamil Liscano (Cali, Colombia - IJMS). The authors found the presence of polar amino acids like arginine, cysteine, and lysine, as well as apolar amino acids like glycine, isoleucine, and leucine. These characteristics are crucial for interactions with bacterial membranes and receptors involved in migration, proliferation, angiogenesis, and immunomodulation.

Exploring the Traditional Uses of Thymbra capitata Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging - Mdpi.com
Article by Jorge Miguel Alves-Silva, Sónia Pedreiro, Maria Teresa Cruz, Lígia Salgueiro and Artur Figueirinha (Coimbra, Portugal - Pharmaceuticals). The present work highlights strong antiradical, anti-inflammatory, and wound healing capacities, corroborating the traditional uses ascribed to this plant. The authors have described, for the first time for this extract, anti-senescent properties.

Diabetic foot ulcer: Successful healing with combination therapy, including surgical debridement, maggot therapy, and negative pressure wound therapy - PubMed
Abstract by Behnam Babamiri, Fatemeh Nikkhah, Navid Faraji, Rasoul Goli, Neda Vahidi Moghaddam and Kamal Rahimi (Iran - Int J Surg Case Rep.).

Reconstruction of foot and ankle defects using the vaccum sealing drainage versus the induced-membrane the elderly: A retrospective comparative study - Wiley.com
Article by Feiya Zhou, Yingying Zhang, Jianyuan Gao, Guangheng Xiang, Zhijie Li and Leyi Cai (Wenzhou, China - International Wound Journal). The purpose of this study was to compare the reconstructive outcomes of soft-tissue defects around foot and ankle with vaccum sealing drainage (VSD) or induction membrane (IM) of cement formation and attempt to provide an optimal strategy for elderly patients.

Revolutionizing wound healing: Ultrashort pulse electric fields in seconds for highly aligned extracellular matrix and efficient cell migration - Sciencedirect.com
Article by Xiao-Wei Xiang, Hao-Tian Liu, Wei Liu, Ze-Yao Yan, Yu-Lian Zeng, Ya-Jun Wang, Jing Liu, Yu-Chen Chen, Sai-Xi Yu, Cai-Hui Zhu, Xiao-Nan Tao et al. (Shanghai, China - Chemical Engineering Journal). The proposed quantitative mechanism for authors' novel microsecond pulse electric filed (μsPEF) methodology orients the new practical electric treatment toward a wide range of biomedical applications, such as wound healing, regenerative medicine and tissue engineering.

Curcumin-Loaded Nanofibrous Matrix Accelerates Fibroblast Cell Proliferation and Enhances Wound Healing via GSK3-β Inhibition - Mdpi.com
Article by Kiran Konain, Nayyer Saddique, Muhammad Samie, Zia Ur Rahman, Sajida Farid, Shazia Hameed, Munazza R. Mirza et al. (Pakistan, China, Korea, USA - J. Compos. Sci.). The authors' results suggest that the developed nanofibrous matrix promotes impaired wound healing by modulating cell proliferation and enhancing FGF expression that promotes wound closure.

Pressure Injuries: Prevention, Evaluation, and Management - PubMed
Abstract by Adam J Visconti, Orlando I Sola and Priya V Raghavan (USA - Am Fam Physician).

Improving knowledge of continence care to prevent skin damage associated with incontinence - PubMed
Abstract by Joanna Peart (Sunderland, UK - Br J Nurs.).

Pressure injury after COVID-19 treated with adjuvant laser therapy: a case study - Scielo.br
Article by Amália de Fátima Lucena, Luciana Ramos Corrêa Pinto, Mitieli Vizcaychipi Disconzi, Márcia Fabris, Beatriz Hoppen Mazui and Deise Lisboa Riquinho (Porto Alegre, Brasil - Rev Gaucha Enferm.). Using laser therapy and the results evaluation and indicators in the follow up of a patient with pressure injury due to COVID-19 showed up as an accurate tool to clinical practice, improving patient safety and quality care.

Digital tools for post-discharge surveillance of surgical site infection - PubMed
Abstract by Camila Dalcól, Judith Tanner and Vanessa de Brito Poveda (Brasil, UK - J Adv Nurs.)

Hybrid Regenerative Therapy for Successful Reconstruction of an Infected Traumatized Diabetic Foot Wound - PubMed
Abstract by Srinjoy Saha (Kolkata, India - Plast Reconstr Surg Glob Open)

Bioengineers test biodegradable bandage for treating chronic wounds - Medicalxpress.com
Article by Kim Krieger. Chronic skin wounds that never heal can be disfiguring and painful. In the journal Biomaterials, University of Connecticut bioengineers describe a special scaffold for new skin that also kills bacteria. Their invention has the potential to help many people heal, and to prevent new chronic wounds from developing in the first place.

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges - Biomedcentral.com
Article by Jia-Yi Ding, Min-Jiang Chen, Ling-Feng Wu, Gao-Feng Shu, Shi-Ji Fang, Zhao-Yu Li, Xu-Ran Chu, Xiao-Kun Li, Zhou-Guang Wang and Jian-Song Ji (China, Germany - Military Medical Research). The authors provide a comprehensive overview of their current status, application potential, and associated drawbacks.

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing - Mdpi.com
Article by Gianina Dodi, Rosina E. Sabau, Bianca E. -B. Creț and Ioannis Gardikiotis (Iasi, Romania - Pharmaceutics). This review paper is the first that examines guar gum vehicles throughout the wound-healing process.

Multi-Functional Chitosan Nanovesicles Loaded with Bioactive Manganese for Potential Wound Healing Applications - Mdpi.com
Article by Edwin Davidson, Jorge Pereira, Giuliana Gan Giannelli, Zachary Murphy, Vasileios Anagnostopoulos and Swadeshmukul Santra (Orlando, USA - Molecules). This study demonstrates the potential of Chi-Mn nanovesicles for wound healing applications.

Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing - Dovepress.com
Article by Xiangjie Fu, Yaqiong Ni, Guanchen Wang, Runda Nie, Yang Wang, Run Yao, Danyang Yan, Mingming Guo and Ning Li (Changsha, China - International Journal of Nanomedicine). The authors' findings emphasize the high suitability of GA/WS-CQDs dressings for MRSA-infected wound healing and their potential for clinical translation.

Risk Factors Associated with Pressure Ulcer Recurrence after Reconstruction: Analysis of a National Database - PubMed
Abstract by Alec McCraine, Ryan Constantine, Nayun Lee, Elliot Le, Michael Gehring and Matthew Iorio (Aurora, USA - Wound Repair Regen.).

Nurses' Knowledge Concerning Prevention and Treatment of Pressure Ulcers - PubMed
Abstract by Panagiota Eirinidou, Georgia Gerogianni, Georgios Vasilopoulos, Ioannis Kalemikerakis, Antonia Kalogianni, Evridiki Kaba, Georgia Fasoi, Afroditi Zartaloudi and Martha Kelesi (Athens, Greece - Adv Exp Med Biol.).

Surgical Wounds: How to Manage Outpatient Care - Woundsource.com
How do you manage a surgical wound in the outpatient setting? In this interview, Erin Testerman-Mitra suggests ways to control moisture-balance, biofilm, and other factors.

Social and Environmental Sources of Disparities in Wound Care - Woundsource.com
Article by Laura Swoboda. Local, environmental, and social variables impact our health, such as toxins, microbes, experience of stress, uncertainty, social isolation, and social injustice. These variables lead to neuro-hormonal responses that affect gene transcription and regulation.

Common Peristomal Skin Complications: How to Prevent and Manage - Woundsource.com
Article by Elizabeth Day Dechant. Peristomal skin complications (PSCs) include inflammation, injury, or damage to the skin surrounding an abdominal stoma. PSCs are among the most common challenges faced by people living with an ostomy, with as high as 80% reported incidence. Complications are highest in individuals with an ileostomy.

Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing - Mdpi.com
Article by Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu and Carmen Solcan (Iasi, Romania - Gels). The authors' results reveal the potential healing effect of CS/PVA/AgNPs/Ib hydrogels and suggest their potential use as wound dressings.

The Use of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcers: A Scoping Review - Cureus.com
Article by Viktor Kunder, Kiran C. Sharma, Zehra Rizvi, Ricardo Soubelet and Monika Ducharme (USA - Cureus). The results of this review provide a baseline for further research on PRP use in patients with diabetes and can be used by physicians and public health experts to guide future treatment options for DFUs.

Is vacuum-assisted closure therapy the main culprit in right ventricular rupture after deep sternal wound infection? - PubMed
Abstract by Ahmed A M Abbas, Iain McPherson and Joel Dunning (Middlesbrough, UK - J Wound Care).

Mitochondria as a Therapeutic: A Potential New Frontier in Driving the Shift from Tissue Repair to Regeneration - Oup.com
Article by Evan N Main, Thaiz M Cruz and Gary L Bowlin (Memphis, USA - Regenerative Biomaterials). This review outlines the potential for mitochondrial transplantation-based therapies as a new frontier of scientific research with respect to driving regeneration in wound healing and host-biomaterial interactions, the current successes of mitochondrial transplantation that warrant this potential, and the critical questions and remaining obstacles that remain in the field.

Burn Management in a Patient With Acute Exacerbation of Comorbid Systemic Lupus Erythematosus - Cureus.com
Article by Bayli P. Davis, Alan Pang, Hussain R. Abidi and John Griswol (Lubbock, USA - Cureus). The authors' case suggeststhat clinicians must carefully weigh the risks of surgical intervention with those of nonoperative management when approaching burn care during an acute rheumatologic disease flare up.

Online (versus face-to-face) augmented reality experience on nursing students’ leg ulcer competency: Two quasi-experimental studies - Sciencedirect.com
Article by Carlos Rodríguez-Abad, Alba-Elena Martínez-Santos, Josefa-del-Carmen Fernández-de-la-Iglesia and Raquel Rodríguez-González (Spain - Nurse Education in Practice). AR positively influences academic performance and diverse educational variables when this experience is carried out online. Since both the online and face-to-face experience show statistically significant benefits in different dimensions of the learning determinants, the need to improve the AR learning experience through blended-learning environments should be promoted.

Efficacy of a Polylactic Acid Matrix for the Closure of Wagner Grade 1 and 2 Diabetic Foot Ulcers: A Single-center, Prospective Randomized Trial - Hmpgloballearningnetwork.com
Article by Brock A. Liden and José L. Ramirez-GarciaLuna (Montreal, Canada - Wounds). The results of this study show PLA matrices induce a potent healing response that leads to reduced healing time and an increased OR for achieving healing by 12 weeks.

Topical metformin accelerates wound healing by promoting collagen synthesis and inhibiting apoptosis in a diabetic wound model - Wiley.com
Article by Fatma Kubra Tombulturk, Tugba Soydas and Gönül Kanigur-Sultuybek (Istanbul, Turkey - International Wound Journal). As a result of the study, the authors showed that metformin increases cellular proliferation and has anti-apoptotic effects by increasing collagen-I/III expression and decreasing p53/c-jun level, especially in diabetic wounds and also in normal wounds. The topical effect of metformin on diabetic wounds reversed the adverse effects caused by diabetes, increasing the wound healing rate and improving the wound repair process.

An injectable, self-healing, and antioxidant collagen- and hyaluronic acid-based hydrogel mediated with gallic acid and dopamine for wound repair - Nature.com
Abstract by Changkai Yang, Yuanzhi Zhang, Xiaoxia Zhang, Pingping Tang, Tingting Zheng, Ruimin Ran and Guoying Li (Chengdu, China - Carbohydrate Polymers).

Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste - Nature.com
Article by Mohamed A. Salem, Osama G. Mohamed, Esraa M. Mosalam, Aya Ibrahim Elberri, Hend Mohamed Abdel-Bar, Mariam Hassan, Ahmed A. Al-Karmalawy et al. (Egypt, USA - Scientific Reports). These results demonstrate that vegetable by-products, particularly, those derived from onion peels can be incorporated as natural by-product for future evaluation against wounds and osteoarthritis.

Mechanism of wound repair in diabetic rats using nanosilver-free alginate dressing - Magonlibrary.com
Abstract by Ying Tang, Zeguo Jia, Xueting Li, Xiaotong Zhao, Shiqi Zhang, Li Luo, Li Xia, Zhaohui Fang, Yuanzhi Zhang and Mingwei Chen (Hefei, China - Journal of Wound Care).

Introduction of augmented reality to the remote wound care nursing consultation system - Magonlibrary.com
Abstract by Toshiaki Takahashi, Aya Kitamura, Masaru Matsumoto, Shiho Higashimura, Gojiro Nakagami and Hiromi Sanada (Japan - Journal of Wound Care).

Management of postpartum perineal wound complications - PubMed
Abstract by Jaber Saad and Caitlyn Painter (San Francisco, USA - Curr Opin Obstet Gynecol.).

A composite hydrogel with antibacterial and promoted cell proliferation dual properties for healing of infected wounds - PubMed
Abstract by Shikun Wei, Zhongshan Wang, Xiaoyan Liang, Tingliang Xiong, Zhengyang Kang, Sheng Lei, Bin Wu and Biao Cheng (Guangzhou, China - Am J Transl Res.).

Effectiveness of negative pressure wound therapy on chronic wound healing: A systematic review and meta-analysis - PubMed
Abstract by Asmat Burhan, Nizam Bin Ali Khusein and Septian Mixrova Sebayang (Indonesia, Malaysia - Belitung Nurs J.).

Association between diabetic retinopathy and diabetic foot ulcer in patients with diabetes: A meta-analysis - Wiley.com
Article by Ziye Li, Jing Wei and Song Lu (Luoyang, China - International Wound Journal). The results of this study suggest that patients with DR have a higher risk of developing DFU, highlighting the importance of regular screening for these two complications to prevent serious adverse outcomes of diabetes.

A meta-analysis comparing the effects of cemented and uncemented prostheses on wound infection and pain in patients with femoral neck fractures - Wiley.com
Article by Ze Xu, Ke Zhang, Kai Cheng, Guangwei Sun, Yaning Zhang and Jian Jia (Linfen, China - International Wound Journal). Existing evidence suggests that the use of cemented prostheses in femoral neck fracture surgery can significantly reduce the incidence of surgical site wound infections and relieve surgical site wound pain, which is worthy of clinical recommendation.

Are current wound classifications valid for predicting prognosis in people treated for limb-threatening diabetic foot ulcers? - Wiley.com
Article by Ya-Chu Chang, Yu-Yao Huang, Shih-Yuan Hung, Jiun-Ting Yeh, Cheng-Wei Lin, I-Wen Chen, Hung-Hui Wei, Hui-Mei Yang and Chung-Huei Huang (Taoyuan City, Taiwan - International Wound Journal). Major adverse cardiac events (MACE) history, levels of C-reactive protein (CRP) and albumin level should assist in prediction; more significantly, only levels of CRP and albumin appeared valid for those subjects undergoing dialysis.

The Wound-Healing Activity of PEDOT-PSS in Animals - Mdpi.com
Article by Yun-Lung Chung, Pei-Yu Chou and Ming-Jyh Sheu (Taiwan - IJMS). In this paper, the authors describe the highly conductive macromolecular material PEDOT: PSS, which demonstrated accelerated wound-healing activity in the animal incision model.

Shifting From Adult to Pediatric Wound Care - Hmpgloballearningnetwork.com
Article by MaryAnne Lewis. A wound is a wound and a centimeter is a centimeter, whether it is being measured in an 8-month-old or an 80-year-old. We see the full circle of life when we witness epidermal thinning, little to no subcutaneous tissue and translucent skin in the elderly. We can work together to find solutions to common problems. We can all take the time to manage pain, and provide the best available treatments.

Calreticulin: A multifunctional protein with potential therapeutic applications for chronic wounds - Frontiersin.org
Abstract by Andrew P. Sawaya, Nicole M. Vecin, Jamie L. Burgess, Gabrielle DiBartolomeo, Rivka Stone, Irena Pastar and Marjana Tomic-Canic (Miami, USA - Front. Med. Sec. Dermatology).

Skin Tears: What Are the First Steps? - Woundsource.com
What are the first steps to treating a skin tear? In this interview, Emily Greenstein describes some best practices for skin tear management, such as marking a dressing for the direction of the skin flap.

3 Misconceptions About Geriatric Wound Patients - Woundsource.com
Is there a difference between hospice and end of life care? In this interview, Maria Goddard sheds light on 3 misconceptions in treating the geriatric population as well as some strategies she uses in her practice.

Pearls and Pitfalls From: Wound Culturing 101 - Woundsource.com
Article by Jennifer Spector. Clinicians should culture with the intent to treat, meaning there is likely an infection that requires systemic antibiotics. Accordingly, wounds classified as contaminated or colonized do not typically require culture. But wounds with signs of covert or overt infection often do.

Healing Helpers: The History of Larval Therapy - Woundsource.com
Article by Christine Miller. Maggots are still useful beyond just that of a natural debriding agent, as they may be a viable weapon against multidrug-resistant infections. Evidence supports its efficacy against methicillin-resistant Staphylococcus aureus (MRSA).

Treatment and Improvement of Healing after Surgical Intervention - Mdpi.com
Article by Andrea Bueno, Endika Nevado-Sanchez, Rocío Pardo-Hernández, Rocío Pardo-Hernández, Raquel de la Fuente-Anuncibay and Jerónimo J. González-Bernal (Burgos, Spain - Healthcare). There are recent research techniques that generate good results and are really promising to improve the results of surgical scars; however, the available evidence is extremely limited in some cases, and it is necessary to deepen its analysis to obtain reliable action protocols in each type of surgery.

Eye health: why diabetes impact eye healing - Diabetes.co.uk
Latest research identifies why people with diabetes take longer to recover from an eye wound compared to those without the condition. Scientists from Cedars-Sinai Medical Center have discovered two related disease-associated changes to the cornea that they were previously unaware of.

Lower-Extremity Vascular Ulcers: Assessment and Approaches to Management - PubMed
Abstract by James B Alexander (Philadelphia, USA - Med Clin North Am.).

Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications - Mdpi.com
Article by Mayar Hassan, Mohamed A. Diab, Miral G. Abd El-Wahab, Abdelrahman H. Hegazi, Abdul-Hamid Emwas, Mariusz Jaremko and Mohamed Hagar (Egypt, Saudi Arabia - Molecules). Coating paper with Bi2O3 enhances the wound-healing potential when applied to wounds. This impact could be ascribed to Bi2O3’s broad antibacterial activity, which reduced infection and accelerated the healing process.

Fibrosis in delayed wound healing in diabetes: the role of insulin-like growth factor binding proteins - Oup.com
Abstract by Sharlene Were, Taryn Wilson, Patricia Martin and Catherine Wright (Glasgow, UK - British Journal of Dermatology).

Differential impact of missed initial wound clinic visit on 6-month wound healing by race/ethnicity among patients with chronic limb-threatening ischemia - PubMed
Abstract by Sydney E Browder, Avital Yohann, Teresa R Filipowicz, Nikki L B Freeman, William A Marston, Stephen Heisler et al. (USA - Wound Repair Regen.).

Laser Biostimulation Induces Wound Healing-Promoter β2-Defensin Expression in Human Keratinocytes via Oxidative Stress - Mdpi.com
Article by Mario Migliario, Preetham Yerra, Sarah Gino, Maurizio Sabbatini and Filippo Renò (Italy - Antioxidants). The authors' findings reveal a novel observation regarding the ability of laser biostimulation to induce the production of hBD-1 and hBD-2 in human keratinocytes through redox-dependent mechanisms. Notably, a single laser treatment within the energy range of 5–50 J demonstrated a significant increase in the levels of hBD-1 and hBD-2 compared to baseline.

A new fasciocutaneous flap model identifies a critical role for endothelial Notch signaling in wound healing and flap survival - Nature.com
Article by Khaled Dastagir, Jaba Gamrekelashvili, Nadjib Dastagir, Anne Limbourg, Dustin Kijas, Tamar Kapanadze, Peter M. Vogt and Florian P. Limbourg (Hannover, Germany - Scientific Reports). The authors' model provides a platform to study vascular adaptation to flap surgery and molecular and cellular regulators influencing flap healing and survival.

Topical Probiotic Formulation Promotes Rapid Healing in Dog Keratinocyte Cells: A Promising Approach for Wound Management - Mdpi.com
Article by Manon Barthe, Lionel Gillot, Laurie Perdigon, Aline Jacobs, Gregory Schoonbroodt, Paul Mauhin, Emna Bouhajja and Hanan Osman-Ponchet (France, Luxembourg - IJMS). The authors' findings suggest the potential beneficial effects of the probiotic-based topical cocktail on wound healing.

The clinical and cost effectiveness of remote expert wound nurse consultation for healing of pressure injuries among residential aged care patients: A protocol for a prospective pilot parallel cluster randomised controlled trial - PubMed
Abstract by Suzanne Kapp, Marie Gerdtz, Charne Miller, Amit Gefen, William Padula, Lauren Wilson, Michael Woodward and Nick Santamaria (Australia, Israel, USA - Int Wound J.).

New insights into balancing wound healing and scarless skin repair - PubMed
Abstract by Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li and Kun Zhang (Zhengzhou, China - J Tissue Eng.).

Is Artificial Intelligence the Future of Wound Care? - Hmpgloballearningnetwork.com
Article by Windy Cole (USA). It is anticipated that AI can be utilized in a variety of ways that extend beyond wound healing into other diagnostic areas within the wound care space. Shifting the focus of wound care from a reactive to a preventative model by suggesting personalized treatment plans will represent a welcome sea change.

Utilizing international consensus panel recommendations and a clinical decision tree to guide selection of negative pressure wound therapy - PubMed
Abstract by Amanda Loney, Rafael J Diaz-Garcia, Julie M Murdoch and Mandy Spitzer (Canada, USA - Wounds).

Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing - PubMed
Abstract by Daoyong Li, Chuanjie Zhang, Zhanshan Gao, Nan Xia, Chao Wu, Chang Liu, He Tian and Xifan Mei (Jinzhou, China - Mol Pharm.).