Evidence for Natural Products as Alternative Wound-Healing Therapies - Mdpi.com
Article by Rachael L. Moses, Thomas A. K. Prescott, Eduard Mas-Claret, Robert Steadman, Ryan Moseley and Alastair J. Sloan (Australia, UK - Biomolecules).
Although there are numerous studies highlighting the effects of naturally occurring small molecules in wound-healing assays in vitro, only evidence from well conducted clinical trials can allow these molecules or the remedies that contain them to progress to the clinic. With this in mind, the authors review wound-healing natural remedies that have entered clinical trials over a twenty-year period to the present.
Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective - Mdpi.com
Article by Nabilah Zulkefli, Che Nur Mazadillina Che Zahari, Nor Hafiza Sayuti, Ammar Akram Kamarudin, Norazalina Saad, Hamizah Shahirah Hamezah, Hamidun Bunawan et al. (Malaysia - IJMS).
The authors have compiled existing evidence on the manipulation of flavonoids towards achieving skin wound healing, together with current limitations and future perspectives in support of these polyphenolic compounds as safe wound-healing agents, in this review.
Why traditional herbal medicine promotes wound healing: research from immune response, wound microbiome to controlled delivery - PubMed
Abstract by Zeyu Xu, Mei Dong, Shaoping Yin, Jie Dong, Ming Zhang, Rong Tian, Wen Min, Li Zeng, Hongzhi Qiao and Jun Chen (Nanjing, China - Adv Drug Deliv Rev.).
Overlapping between Wound Healing Occurring in Tumor Growth and in Central Nervous System Neurodegenerative Diseases - Mdpi.com
Article by Domenico Ribatti, Vincenzo Benagiano and Diego Guidolin (Italy - Brain Sciences).
The aim of this article is to emphasize and compare the role of wound healing in two different pathological conditions, namely tumor growth and central nervous system neurodegenerative diseases. Both are conditions in which wounds fail to heal, as occurs in physiological conditions.
Physical Treatment of Diabetic Foot Ulcers – Preliminary Study for Topical Application of Oxygen or Ozone Auxiliary Treatment of Diabetic Foot Ulcers - Hindawi.com
Article by Jarosław Pasek Sebastian Szajkowski and Grzegorz Cieślar (Poland . Dermatologic Therapy).
The aim of the study was to compare the efficacy of two physical therapeutic methods: topical oxygen therapy and topical ozone therapy in the treatment of DFU with the calculation of the financial costs for both applied physical methods.
Photobiomodulation with Blue Light on Wound Healing: A Scoping Review - Mdpi.com
Abstract by Thais P Prado, Flávia Cristina Zanchetta, Beatriz Barbieri, Caroline Aparecido, Maria Helena Melo Lima and Eliana P Araujo (Campinas, Brazil - Life (Basel)).
Wound Pain: Do You Know the Physiology? - Woundsource.com
Article by Thanoon Thabet.
Pain undeniably affects wound care management practice, making it vital. However, clinicians may overlook pain as a factor during wound care and healing. Unresolved pain harms the patient's quality of life and healing efficacy, thus necessitating clinicians to adopt effective wound care management strategies.
A multifunctional sateen woven dressings for treatment of skin injuries - PubMed
Abstract by Ceren Ozel, Elif Apaydin, Ayla Eker Sariboyaci, Ali Tamayol and Huseyin Avci (Eskişehir, Turkey - Colloids Surf B Biointerfaces).
Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional nanofibrous patches for efficient healing of diabetic wounds - Nature.com
Article by Isra H. Ali, Islam A. Khalil and Ibrahim M. El-Sherbiny (Giza, Egypt - Scientific Reports).
In vivo results showed that the patches were successful in inducing proper wound healing in diabetic rat model. This was confirmed through assessing wound closure as well as from histopathological studies that showed complete healing with proper cell regeneration and arrangement without forming scars.
Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review - PubMed
Abstract by Janaina Daniel Ouchi, Regina Mara Silva Pereira and Cristina Eunice Okuyama (São Paulo, Brazil - Adv Skin Wound Care).
Neonatal Electroencephalogram Electrode-Related Pressure Injury Prevention Quality Improvement Study - PubMed
Abstract by Laura A Blazier, Frances A Boyle, Kristin L Cooper, Sarah E Wing and Beatrice M Stefanescu (Indianapolis, USA - Adv Skin Wound Care).
Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats - Nature.com
Article by Fereshteh Nejaddehbashi, Zeinab Rafiee, Mahmoud Orazizadeh, Vahid Bayati, Aliasghar Hemmati, Mahmoud Hashemitabar and Pooyan Makvandi (Iran, Sweden, Italy, China - Scientific Reports).
The double-layered nanofibrous mat containing GSE and SSD used in the present study could be considered as a suitable wound dressing in order to shorten healing time and prevent infection during the wound healing process.
First-of-its-kind wireless, battery-free bandage accelerates wound healing - News-medical.net
Article by Emily Henderson.
Northwestern University researchers have developed a first-of-its-kind small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site. In an animal study, the new bandage healed diabetic ulcers 30% faster than in mice without the bandage.
Use of 3-dimensional printing at the point-of-care to manage a complex wound in hemifacial necrotizing fasciitis: a case report - Biomedcentral.com
Article by Sarah C. Nyirjesy, Ryan T. Judd, Yazen Alfayez, Peter Lancione, Brian Swendseid, Natalia von Windheim, Stephen Nogan, Nolan B. Seim and Kyle K. VanKoevering (Columbus, USA - 3D Printing in Medicine).
Patient-specific, three-dimensional printing is an innovative solution that can facilitate safe placement of negative pressure wound therapy adjacent to delicate structures. This report also demonstrates feasibility of point-of-care manufacturing of customized devices for optimizing complex wound management in the head and neck.
Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing - Mdpi.com
Article by Filippo Renò and Maurizio Sabbatini (Italy - Biomedicines).
In this review, the authors have highlighted recent advances in understanding the biology underlying lymphangiogenesis and its key role in wound healing, and the possibility of its pharmacological modulation as a novel therapeutic strategy for the treatment of chronic wounds.
Barriers and facilitators to use of compression therapy by people with venous leg ulcers: A qualitative exploration - Wiley.com
Article by Catherine Perry, Ross A. Atkinson, Jane Griffiths, Paul M. Wilson, Jacqueline F. Lavallée, Nicky Cullum and Jo C. Dumville (Manchester, UK - Journal of Advanced Nursing).
The aim of this research was to explore barriers to, and facilitators of, adherence to compression therapy, from the perspective of people with venous leg ulcers.
An Updated Review of Hypertrophic Scarring - Mdpi.com
Article by Manjula P. Mony, Kelly A. Harmon, Ryan Hess, Amir H. Dorafshar and Sasha H. Shafikhani (Chicago, USA - Cells).
In this review article, the authors provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling).
Nurse Paralegal: The Process in Practice - Woundsource.com
Article by Lydia Corum.
Nurses are trained to gather information, analyze it, and form issues to report to a doctor. Paralegals are trained in the IRAC method (Issue, Rule, Analysis, and Conclusion). How do these 2 ways of thinking work together?
Litigation Basics: What Health Care Professionals Need to Know - Woundsource.com
Article by Heidi Cross.
Lawsuits related to pressure injuries and malnutrition are becoming more common, with recovery against a health care facility in 87% of cases filed, including jury verdicts and out of court settlements.
Combination of Biomaterials and Extracellular Vesicles from Mesenchymal Stem-Cells: New Therapeutic Strategies for Skin-Wound Healing - Mdpi.com
Article by Victoria Pulido-Escribano, Bárbara Torrecillas-Baena, Gabriel Dorado, María Ángeles Gálvez-Moreno, Marta Camacho-Cardenosa and Antonio Casado-Díaz (Córdoba, Spain - Applied Sciences).
The aim of this review is to critically describe the latest advances in the development of such therapeutic strategies. It highlights the significance and clinical potential of these new therapies, as well as the need to develop clinical trials, to ascertain their performance.
Home Care Settings and Wound Management - Woundsource.com
Health care delivered in the home or outpatient setting has continued to increase. According to the latest figures in 2018 and 2017, over 11,500 home care agencies treated 4.9 million individuals in the United States. As the aging population increases, the nuances of optimal wound care delivery in the home health setting should be examined.
Liver Insulin-like Growth Factor-1 mediates effects of low-intensity vibration on wound healing in diabetic mice - Wiley.com
Abstract by Rita E. Roberts, Jacqueline Cavalcante-Silva, Mercedes Del Rio-Moreno, Onur Bilgen, Rhonda D. Kineman and Timothy J. Koh (Chicago, USA - The Journal of Pathology).
Wound debridement - Hospitalnews.com
Article by Erin M. Rajhathy.
Wound debridement refers to the removal of necrotic tissue from the wound bed and is essential in the care and management of healable chronic wounds. Debridement also removes other contaminants from the wound surface including foreign debris, leftover dressing material, and single or complex networks of bacteria (e.g., biofilm) all of which can stall the normal wound healing trajectory.
From burns to acne, stem cell therapy can help you deal with these skin problems - Healthshots.com
Stem cell therapy is a great way to deal with skin problems, including acne, burns, wounds, and more. Read on the know everything about this technology that can work wonders for your skin.
Extracellular Vesicle-Based Hydrogels for Wound Healing Applications - Mdpi.com
Article by Andreu Miquel Amengual-Tugores, Carmen Ráez-Meseguer, Maria Antònia Forteza-Genestra, Marta Monjo and Joana M. Ramis (Palma, Spain - IJMS).
The aim of this review was to describe the reported EV-based hydrogel combinations, along with the obtained results, and analyze future perspectives.
An older diabetes-induced mice model for studying skin wound healing - Plos.org
Article by Carlos Poblete Jara, Guilherme Nogueira, Joseane Morari,Thaís Paulino do Prado, Renan de Medeiros Bezerra, Lício A. Velloso, William Velander and Eliana Pereira de Araújo (USA, Brazil - Plos One).
The authors' unique model is perhaps useful to therapeutic development for the treatment of human decubitus ulcers.
Protocol-driven Therapy for Lower Extremity Ulcers: A Case Series Supporting the Use of Porcine Intestine Extracellular Matrix - Hmpgloballearningnetwork.com
Article by Diana Isabel Cáceres, Leydi Castro, Nelly Esperanza Jaimes, Luis Fernando Orduz and Maria Andreina Pulido (Girón, Colombia - Index Wounds).
The findings of this study demonstrate the efficacy of an evidence-based wound management protocol in achieving safe, complete tissue regeneration in a short period of time.
Treating scars with light - Eurekalert.org
In a scene in the movie Avatar, the Tree of Souls treats injured Na’vi people with light. However, it seems that the Na’vi in the film are not the only ones who can treat wounds with light. It is said that during ancient Egyptian times, leukoplakia was cured with sunlight and in 1903, the Nobel Prize was awarded for treatment of tubercular skin disease with light. In modern days, light therapy is used to treat various diseases, such as skin diseases and cancer.
Treatment for burn wounds could be revolutionized through Wichita State research - Wichita.edu
Every year, there are roughly 450,000 burn wounds that require clinical care throughout the United States. Of those, more than 3,500 people are fatally injured. An interdisciplinary team of Wichita State University researchers is working to revolutionize burn-wound care with a scaffolding system that prevents infection and promotes healing.
Hospital-acquired skin lesions in the neonatal intensive care unit: A retrospective analysis of temporal trends and quality improvement strategies - PubMed
Abstract by Barbara Fassino, Silvia Ferrario, Gabriele Sorrentino, Ileana Adamini, Nicola Pesenti, Monica Fumagalli, Fabio Mosca and Laura Plevani (Milan, Italy - J Pediatr Nurs.)
Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications - Mdpi.com
Article by Maria Psarrou, Anna Mitraki, Maria Vamvakaki and Chrysoula Kokotidou (Heraklion, Greece - Polymers).
This review highlights the recent advances in stimuli-responsive polysaccharide hydrogels and their composites for use in wound healing applications.
Role for platelet rich plasma as an adjuvant therapy in wound healing and burns - Springer.com
Article by Nauar Knightly, Crystal Lee, Lukas O’Brien, Tayyab Qayyum, Ciaran Hurley and Jack Kelly (Dublin, Ireland - European Journal of Plastic Surgery).
With the current body of evidence, the authors conclude that the use of PRP as an adjuvant therapy in skin grafts, burns, carpal tunnel surgery or scars cannot be rationalised. A potential use of PRP is in donor site management but the cost of this would be difficult to justify.
A systematic review of nurses' knowledge and related factors towards the prevention of medical device-related pressure ulcers - PubMed
Abstract by Arman Parvizi, Soudabeh Haddadi, Amirabbas Mollaei, Pooyan Ghorbani Vajargah et al. (Iran - Int Wound J.)
Research progress and insights on the role of ferroptosis in wound healing - Wiley.com
Article by Minglei Bi, Danyi Li and Jin Zhang (China - International Wound Journal).
This review systematically summarises the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment.
Chelating the valley of death: Deferoxamine’s path from bench to wound clinic - Frontiersin.org
Article by Jennifer B. Parker, Michelle F. Griffin, Mauricio A. Downer, Deena Akras, Charlotte E. Berry, Asha C. Cotterell, Geoffrey C. Gurtner, Michael T. Longaker and Derrick C. Wan (USA - Front. Med.).
A strong foundation of basic scientific research now supports DFO's potential use in chronic wounds and RIF. Though additional milestones remain to be completed regarding DFO treatment in wound healing and fibrosis, the authors are hopeful to bridge that gap from bench to wound clinics in the near future.
Portable Nanocomposite System for Wound Healing in Space - Mdpi.com
Article by Chiara Zagni, Andrea Antonino Scamporrino, Paolo Maria Riccobene, Giuseppe Floresta, Vincenzo Patamia, Antonio Rescifina and Sabrina Carola Carroccio (Catania, Italy - Nanomaterials).
The authors propose a hybrid system based on the biocompatible poly 2-hydroxyethyl methacrylate (pHEMA) to actively support a nanocontainer filled with the drug.
Role of macrophage polarisation in skin wound healing - Wiley.com
Article by Xuejun Gao, Chao Lu, Yuanxin Miao, Jizhen Ren and Xia Cai (Qingdao, China - International Wound Journal).
Macrophage polarisation and activation are critical for skin wound healing. While exogenous M1 cell infusion delayed wound healing, the M2 cells promoted wound healing in a rat model.
Liquid plasma as a treatment for cutaneous wound healing through regulation of redox metabolism - Nature.com
Article by Hye Ran Lee, Sung Un Kang, Haeng Jun Kim, Eun Jong Ji, Ju Hyun Yun, Sungryeal Kim, Jeon Yeob Jang, Yoo Seob Shin and Chul-Ho Kim (South Korea - Cell Death & Disease).
The authors' findings indicate that LP could be a valuable wound management material that can improve the regeneration potential of the skin via the activation of migration-related molecular signaling within the epithelial cell itself with plasma-driven oxidative eustress.
Biomedical materials for wound dressing: recent advances and applications - Rsc.org
Article by Hien Minh Nguyen, Tam Thi Ngoc Le, An Thanh Nguyen, Han Nguyen Thien Le and Thi Tan Pham (Ho Chi Minh City, Vietnam - RSC Adv.).
Due to the different types of wounds, as well as the variety of advanced wound dressing products, this review will provide information on the clinical characteristics of the wound, the properties of common modern dressings, and the in vitro, in vivo as well as the clinical trials on their effectiveness.
Burns: Classification, Pathophysiology, and Treatment: A Review - Mdpi.com
Article by Wojciech Żwierełło, Krzysztof Piorun, Marta Skórka-Majewicz, Agnieszka Maruszewska, Jacek Antoniewski and Izabela Gutowska (Poland - IJMS).
The publication discusses disorders occurring in patients after thermal injury and the methods used at various stages of treatment.
MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1 - Nature.com
Article by Qiankun Li, Wenzhi Hu, Qilin Huang, Jie Yang, Bingmin Li, Kui Ma, Qian Wei, Yaxi Wang, Jianlong Su, Mengli Sun, Shengnan Cui, Rungong Yang, Haihong Li, Xiaobing Fu and Cuiping Zhang (China - Signal Transduction and Targeted Therapy).
The authors efficient exosome and biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering.
Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers - Nature.com
Article by Jiaming Cui, Siqi Zhang, Songmiao Cheng and Hai Shen (China - Front. Bioeng. Biotechnol.).
This review provides a “loading component shelf” for researchers of composite hydrogels and a theoretical basis for the future construction of “all-in-one” hydrogels.
The Effects of Chitosan on the Healing Process of Oral Mucosa: An Observational Cohort Feasibility Split-Mouth Study - Mdpi.com
Article by Gonçalo de Jesus, Lara Marques, Nuno Vale and Rui Amaral Mendes (Portugal, USA - Nanomaterials).
Chitosan seems to improve the postoperative quality of patients, allowing rapid wound healing with less complications.
Pressure ulcer prevention, patient positioning and protective equipment - PubMed
Abstract by Mark Collier, Sarah Jones and Gilly Glendewar (UK - Br J Nurs.).
Adjusting body weight for edema in severely burned patients - PubMed
Abstract by Beth A Shields, Sandrine O Fossati, Renee E Cole, Adam J Kieffer, Saul J Vega, James K Aden, Alicia M Williams and Leopoldo C Cancio (Fort Sam Houston, USA - Burns).
Current Therapeutic Modalities for the Management of Chronic Diabetic Wounds of the Foot - Hindawi.com
Article by Olajumoke Arinola Oyebode, Sandy Winfield Jere and Nicolette Nadene Houreld (Doornfontein, South Africa - Journal of Diabetes Research).
This review discusses the causes of diabetic wounds and current therapeutic modalities for the management of DFUs, specifically wound debridement and dressing, TENS, nanomedicine, shockwave therapy, HBOT, TOT, and PBM.
Compounds for cancer, psychiatric conditions improve wound healing in cells - Fiercebiotech.com
Article by Helen Floersh.
Scientists from the University of California, Los Angeles (UCLA) have found that using drugs that modulate a key circadian rhythm protein can potentially reduce scar tissue buildup. They found that two of those drugs reduced the healing time and also the creation of excess collagen, the mechanism that drives hypertrophic scarring.
The work is the first step toward identifying a new means of helping postoperative scars heal better.
Colonizing microbiota is associated with clinical outcomes in diabetic wound healing - PubMed
Abstract by Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K Reddy, Zhiqi Hu and Luis Garza (USA, China - Adv Drug Deliv Rev.).
Wound healing in stage IV pressure injury with use of adjunct autologous activated platelet-rich plasma therapy: a case report - PubMed
Abstract by Karina Karina, Dinar Rahmania, Hubert Andrew, Krista Ekaputri, Johannes Albert Biben and Nungki Ratna Martina (Indonesia - Wounds).
The Nursing Home Severity Index and Application to Pressure Injury Risk: Measure Development and Validation Study - PubMed
Abstract by Tracey L Yap, Susan D Horn, Phoebe D Sharkey, Katie R Brooks and Susan Kennerly (USA - JMIR Aging).
Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review - Mdpi.com
Article by Kaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jan, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar,Vesna Spasovski et al. (Slovenia, Serbia - IJMS).
According to the literature findings, PVRP represents a promising therapeutic option for several pathophysiologic states in human and veterinary medicine. It also gives an alternative option in reproductive medicine for ovaries rejuvenation, in emergency medicine for treatment of burns and bone fractures, as well as in otorhinolaryngology, head and neck surgery, dental and aesthetic medicine.
Evaluation of low-level laser therapy and platelet-rich fibrin on donor site healing after vascularized interpositional periosteal connective tissue flap: a randomized clinical study - Springer.com
Article by Sadaf Mukhtar, Vivek Kumar Bains, Chetan Chandra and Ruchi Srivastava (India - Lasers in Medical Science).
Favourable clinical outcomes in terms of tissue thickness, consistency, color, contour, scar, pain, and burning sensation and patient comfort were obtained in both LLLT- and PRF-treated donor palatal sites at 12 weeks.
Efficacy validation of "pure" venous lymph node flap in a rat lymphedema model - PubMed
Abstract by Chunxiao Cui, Fabio Nicoli, Peiru Min, Ke Li and Yixin Zhang (China, UK, Italy - Wound Repair Regen.).
Dynamic characteristics of skin reaction force in different body postures - Nature.com
Article by Nick Marsidi, Karlijn M. J. Scheepens, Jelle J. Goeman, Tim Horeman and Roel E. Genders (The Netherlands - Scientific Reports).
The authors' results demonstrate that the skin reaction force in four directions in four locations varies with change in body posture. Focus should therefore not only lay on choosing the right direction, but also on managing skin tension postoperatively.
Novel Bioengineered Collagen with Manuka Honey and Hydroxyapatite Sheet for the Treatment of Lower Extremity Chronic Wounds in an Urban Hospital Wound Care Setting - Hmpgloballearningnetwork.com
Article by Isaac Rodriguez, Alejandra Alvarez, Cara Massey, LaDawn Miller, Rene Rannou, Martin Croce and Tony Alleman (Memphis, USA - Wounds).
This retrospective evaluation showed average time to wound closure to be significantly faster with BCMH compared with standard of care in patients who maintained adherence with regular visits.
Use of negative pressure wound therapy to successfully treat postoperative pyoderma gangrenosum following laparoscopic surgery: a case report - PubMed
Abstract by Vincent van Grinsven, Ernest Schouppe and Tim Tollens (Belgium - Wounds).
The sandwich technique for quick and efficient application of negative pressure wound therapy to the feet and hands: a case report - PubMed
Abstract by Austin Rollins, Kristie Ho, Luis G Fernandez, Marisse A Lardizabal, Bryan Roth, Sean F O'Keefe and Marc R Matthews (USA - Wounds).
Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study - Mdpi.com
Article by Alessia Paganelli, Andrea Giovanni Naselli, Laura Bertoni, Elena Rossi, Paola Azzoni, Alessandra Pisciotta, Anna Maria Cesinaro, Luisa Benassi, Shaniko Kaleci, Federico Garbarino, Barbara Ferrari, Chiara Fiorentini, Camilla Reggiani and Cristina Magnoni (Modena, Italy - Life).
Even in the presence of subtle differences between the ADMs, comparable global outcomes were demonstrated after dermato-oncological surgery.
Use of autologous whole blood clot in the treatment of complex surgical wounds: a case series - Magonlibrary.com
Article by Maxim Gurevich, Stephen M Heinz, Ruhama Fridman, Jessie Hawkins and Chinenye D Wachuku (Israel, USA - Journal of Wound Care).
Autologous whole blood clot treatment in hard-to-heal surgical wounds was found to be an effective approach, reducing the risk of infection and promoting cell granulation, resulting in wound closure.
In vitro responses of human dermal fibroblasts to mechanical strain: A systematic review and meta-analysis - Frontiersin.org
Article by L. van Haasterecht, C. Dsouza, Y. Ma, H. I. Korkmaz, Y. de Jong, J. C. F. Ket, P. P. M. van Zuijlen, M. L. Groot and S. V. Komarova (The Netherlands, Canada - Front. Mech. Eng.).
The authors from this study that distinct differences exist in the effects of mechanical stretching between dermal fibroblasts from neonatal and adult donors, which will help to further elucidate the pathophysiological mechanism behind tension-induced scarring.
Effect of Negative Pressure Wound Therapy on Surgical Site Infections following Stoma Reversal in Colorectal Surgery: A Meta-Analysis - Tandfonline.com
Article by Junjia Zhu, Qi Sun, Wenlong Xu, Jun Geng, Qiang Feng, Zhenguo Zhao and Sen Li (Jiangyin, China - Journal of Investigative Surgery).
The use of NPWT following stoma reversal in colorectal surgery reduced the incidence of surgical site infections. However, this conclusion needs to be interpreted with caution, and further studies should be conducted to confirm in higher-quality randomized controlled trials.
Acute Treatment of Extravasation Injuries in Neonates: Polymeric Membrane Dressings - Woundsource.com
Article by Elizabeth Dechant.
Hospitalized patients of all ages are at risk for iatrogenic injuries. Peripheral intravenous extravasation and infiltration (PIVIE) injuries are one of the most common types of hospital-acquired injury, with the potential to cause long-term disfigurement or loss of function.
Never Events and Serious Reportable Events in Wound Care - Woundsource.com
The National Quality Forum (NQF) introduced the term never event in the early 2000s, and it refers to a preventable error that may represent fundamental issues with the quality or safety of care within a medical setting. This wording was initially selected because these events are situations that should never happen to any patient, such as surgery to the wrong leg or leaving a sponge in a patient after surgery.
The role of proinflammatory cytokines in the detection of early pressure ulcer development: a systematic review - PubMed
Abstract by Mai Shanley Chan, Pinar Avsar, Natalie L McEvoy, Declan Patton, Tom O'Connor, Linda Nugent and Zena Moore (Ireland, Saudi Arabia, Australia, Belgium, UK - J Wound Care).
Clinical benefits of small intestinal submucosa extracellular matrix and review of the evidence - PubMed
Abstract by Steven Jeffery (Birmingham, UK - J Wound Care).
Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings - Nature.com
Article by Christopher Doherty, Charlotte V. Byrne, Sajwa Baqader, Cecile El-Chami, Andrew J. McBain and Helen A. Thomason (UK, Saudi Arabia - Scientific Reports).
The different physicochemical properties of the silver dressings result in varied effects on wound biofilms and healing which should be considered when selecting dressings to treat biofilm-infected wounds.
Pressure injury prevention in older people: construction and validation of an instrument for caregivers - PubMed
Abstract by Suellen Duarte de Oliveira Matos, Ana Paula Marques de Andrade Souza, Margarida da Silva Neves de Abreu, Anne Carolinne Marie Dos Santos Gomes, Jacira Dos Santos Oliveira, Mirian Alves da Silva, Maria Júlia Guimarães Oliveira Soares and Simone Helena Dos Santos Oliveira (Brazil, Portugal - Rev Bras Enferm.).
Effects of wounds in the cell membrane on cell division - PubMed
Abstract by Md Istiaq Obaidi Tanvir and Shigehiko Yumura (Yamaguchi, Japan - Sci Rep.).
Role of autologous fat transplantation combined with negative-pressure wound therapy in the treatment of diabetic wounds in a rat model - PubMed
Abstract by Hao Zhang, Min Zhou, Yu Wang, Dong Zhang, Baiwen Qi and Aixi Yu (Wuhan, China - Plast Reconstr Surg.).
Fascia Layer – A Novel Target for the Application of Biomaterials in Skin Wound Healing - Mdpi.com
Article by Haifeng Ye and Yuval Rinkevich (Munich, Germany - IJMS).
The authors found that the fascial layer has an indispensable role in wound healing and repair, and this review summarizes the research progress of related bioactive materials and their role in wound healing.
Mechanisms underlying pathological scarring by fibroblasts during wound healing - Wiley.com
Article by Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan and Suling Xu (Ningbo, China - International Wound Journal).
The authors' findings suggest that understanding the causes of abnormal FB formation may aid in the development of precise and effective preventive and treatment strategies for pathological scarring that are associated with improved quality of life of patients.
Minimizing Bias in a Diabetic Foot Ulcer Clinical Evaluation: Analysis of the HIFLO Trial - Hmpgloballearningnetwork.com
Article by Paul Glat, Lisa Gould, Lael J Pickett and Douglas M Arm (San Diego, USA).
High-level agreement by blinded adjudicators confirmed that DFUs in the HIFLO Trial were consistently assessed for healing without bias, validating the most rigorous assessment criteria to date. The findings reported herein may prove beneficial for others seeking to minimize bias in wound studies.
Primary Closure or Secondary Wound Healing of Pin Sites After External Fixator Removal - A Single-Center Blinded Randomized Controlled Trial - Lww.com
Abstract by Franz Tillmann, Ruben Hoepelman, Flavio Cagienard, Björn-Christian Link, Reto Babst, Bryan van de Wall, and Frank J. P. Beeres (Switzerland, The Netherlands - The Journal of Bone and Joint Surgery).
Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing - Mdpi.com
Article by Lorenz M. Brunner, Yuliang He, Nikola Cousin, Jeannette Scholl, Livia K. Albin, Bianca Schmucki, Sandrin Supersaxo, Gaetana Restivo, Jürg Hafner, Dario Neri, Sabine Werner and Michael Detmar (Switzerland, Cells).
The authors' findings indicate that activating the lymphatic vasculature might represent a new therapeutic strategy for treating chronic non-healing wounds.
HuMSC-EV induce monocyte/macrophage mobilization to orchestrate neovascularization in wound healing process following radiation injury - Nature.com
Article by Céline Loinard, Alexandre Ribault, Bruno Lhomme, Marc Benderitter, Stéphane Flamant, Sandrine Paul, Valérie Dubois, Ruenn Chai Lai, Sai Kiang Lim and Radia Tamarat (France, Singapore - Cell Death Discovery).
This study demonstrates that HuMSC-derived EV enhances the neovascularization process in the irradiated tissue by increasing the production of proangiogenic factors, promoting the recruitment of vascular progenitor cells, and the mobilization of innate cells to the injured site.
Medicines that modify the circadian clock might help heal scars more cleanly - Frontiersin.org
Article by Angharad Brewer Gillham.
Scientists determined that compounds which play key roles in both collagen synthesis and circadian management can be used to make wounds on cell samples heal more quickly and effectively, offering promise for treatments to prevent problem scarring in the future.
Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis? - Biomedcentral.com
Article by Martin Albrecht, Lars Hummitzsch, Rene Rusch, Katharina Heß, Markus Steinfath, Jochen Cremer, Frank Lichte, Fred Fändrich, Rouven Berndt and Karina Zitta (Kiel, Germany - Journal of Translational Medicine).
The authors propose that L-EVMreg could represent a putative therapeutic option for the treatment of chronic wounds and ischemia-associated diseases.
Development of Decellularized Fish Skin Scaffold Decorated with Biosynthesized Silver Nanoparticles for Accelerated Burn Wound Healing - Hindawi.com
Article by Surya Prasad Adhikari, Astha Paudel, Anisha Sharma, Baruna Thapa, Neha Khanal, Nisha Shastri, Sourav Rai and Rameshwar Adhikari (Nepal - International Journal of Biomaterials).
A novel scaffold with antibacterial activity was successfully prepared using decellularized fish skin scaffold and biosynthesized silver nanoparticles.
Novel cell culture system for monitoring cells during continuous and variable negative-pressure wound therapy - PubMed
Article by Toshifumi Yamashiro, Toshihiro Kushibiki, Yoshine Mayumi, Masato Tsuchiya, Miya Ishihara and Ryuichi Azuma (Saitama, Japan - Skin Res Technol.).
developed a negative-pressure cell culture device that enables negative-pressure cell culture under conditions similar to those used in clinical practice and is able to monitor cells under NPWT. Further experiments using this device would provide high-quality molecular biological evidence for NPWT.
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