Hungarian Wound Care Society

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News from the field of wound care and wound healing - June, 2023

Dynamic Kinesiotherapy: A Novel Technique That Promotes Appropriate Abdominal Wound Healing - Cureus.com
Article by Andrzej Ratajczak, Małgorzata Ratajczak-Lange, Kinga Zastawna, Abdalla Saad Abdalla Al-Zawi and Tomasz Banasiewicz (Poland, UK). The authors introduce a novel, effective technique that facilitates appropriate surgical wound healing. Dynamic kinesiotherapy is an easy procedure to perform, handy, beneficial, safe, and cost-effective.


Recognition and Treatment of Wounds in Persons Using Xylazine: A Case Report From New Haven, Connecticut - Lww.com
Abstract by Anne Dowton, Molly Doernberg, Erica Heiman, Peter Barelli et al. (New Haven, USA - Journal of Addiction Medicine).


Effect of various repositioning regimens on pressure wound ulcer occurrence in at-risk adult persons without existing pressure wound ulcers: A meta-analysis - PubMed
Abstract by Mei Zeng, Yuan Li, Juan Hu, Miao Peng, Yingchun Hu and Chengli Zhou (Luzhou, China - Int Wound J.).


Multi-Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management - Wiley.com
Article by Wenzhao Li, Yunru Yu, Rongkang Huang, Xiaocheng Wang, Puxiang Lai, Kai Chen, Luoran Shang and Yuanjin Zhao (China - Advanced Science). Inspired by snail mucus and octopus suction-cup, we designed a highly integrated hydrogel patch with NIR-controlled adhesion, anti-microbial, drug release, and physiological monitoring features for wound healing management.


Biopsy in Wound Care: Insights from A Leading Dermatologist - Hmpgloballearningnetwork.com
Video by Robert Kirsner. The beauty of taking a biopsy is you can control what you're biopsying. The depth and the location of where you want to take a biopsy. So in dermatology, if we see something that we think is a skin cancer we'll take a very superficial biopsy, because the pathology is very high. Many times in wounds we want to go deeper.


Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds - Hmpgloballearningnetwork.com
Abstract by Patrik Stenlund, Linnea Enstedt, Karin Margaretha Gilljam, Simon Standoft, Astrid Ahlinder et al. (Sweden, Norway - Polymers (Basel)).


Impact on peri-implant connective tissue of laser treated versus traditional healing abutments: a human clinical trials - Biomedcentral.com
Article by Giulia Gaggi, Andrea Di Credico, Gianmaria D’Addazio, Barbara Ghinassi, Giulio Argentieri, Sergio Caputi, Angela Di Baldassarre and Bruna Sinjari (Chieti, Italy - BMC Oral Health). The laser-treated surface holds promise in positively influencing wound healing of peri-implant connective tissue. Results demonstrated that topographic nature of the healing abutments can positively influence mucosal wound healing and molecular expression.


Innovative paper-like, battery-free, AI-enabled sensor for holistic wound monitoring - Eurekalert.org
Low-cost and versatile patch can be customized for different types and sizes of wounds, and provides early warning of adverse conditions to facilitate wound care and management.


Cryogels: Advancing Biomaterials for Transformative Biomedical Applications - Mdpi.com
Article by Hossein Omidian, Sumana Dey Chowdhury and Niloofar Babanejad (USA - Pharmaceutics). Combination therapies and drug delivery systems using cryogels show promise. In vivo evaluation and clinical trials are crucial for safety and efficacy.


Wound Care: Enhancing Healthcare for the Aging Population - Woundeducators.com
Wound care plays a crucial role in providing effective healthcare, particularly for the aging population. With age, individuals face an increased risk of developing chronic wounds due to various age-related conditions. In this article, the authors will explore the impact of chronic conditions on wound development, the influence of aging on wound healing, and the essential role of healthcare workers, including wound care specialists and hospice workers, in managing and treating wounds effectively.


Necrotizing Fasciitis: What is it? - Woundsource.com
Article by Cathy L. Harmon. Necrotizing fasciitis (NF), commonly referred to as the "flesh-eating bacteria", is a bacterial organism that quickly invades and destroys skin tissue. The most common cause of necrotizing fasciitis is group A Streptococcus. Necrotizing means "death of tissue", fasciitis refers to the involved tissue, fascia.


Non-pharmacological Pain Management: What’s Out There? - Woundsource.com
For those struggling with pain, what alternative pain management techniques are available? Thanoon Thabet discusses various pain management therapies available for clinicians looking for solutions outside of medications.


Revolutionizing Wound Care for People with Diabetes: A Closer Look at Advanced Technologies - Diabeteshealth.com
For people living with diabetes, managing wounds can be a significant challenge. Diabetes can impair the body’s ability to heal correctly, leading to slow-healing wounds and an increased risk of infections. However, advancements in wound care technology have brought new hope and improved outcomes for people with diabetes.


Antibacterial nanocomposite of chitosan/silver nanocrystals/graphene oxide (ChAgG) development for its potential use in bioactive wound dressings - Nature.com
Article by Yoxkin Estévez-Martínez, Rubí Vázquez Mora, Yesica Itzel Méndez Ramírez et al. (Mexico - Scientific Reports). The proposed ChAgG nanomaterial will be useful for functionalizing specific fiber network that represents current challenging research in the fabrication of bioactive wound dressings.


Factors Affecting Platelet-Rich Plasma Success in Patients With Diabetic Foot Ulcer - Cureus.com
Article by Eyüp Murat Kanber and Harun Gulmez (Istanbul, Turkey). It was found that PRP was an effective treatment that improved DFU in 141 out of 182 patients. Moreover, the present study demonstrated for the first time that higher BMI, longer duration of DM, smoking, and lower GFR were significantly related to PRP failure in patients with DFU.


Laser in the Treatment of Atonic Wounds - Mdpi.com
Article by Maur Sebastian Horgos, Ovidiu Laurean Pop, Mircea Sandor, Ioan Lucian Borza et al. (Oradea, Romania - Biomedicines). The authors consider that this therapy is of major importance considering the lower costs both from the shortening of hospitalization and the long-term use of various substances. The early reintegration of patients into daily life is an important benefit for them.


Machine learning used to identify diverse cellular roles in the corneal wound healing responses - Arvojournals.org
Abstract by Kristen Segars, Nicholas Azzari, Celeste B Rich and Vickery E Trinkaus-Randall (Boston, USA - IOVS).


Temporal Cluster Analysis of Deep Sternal Wound Infection in a Regional Quality Collaborative - PubMed
Abstract by Andrew D Hawkins, Erik J Scott, Jeison De Guzman, Sarah J Ratcliffe, J Hunter Mehaffey et al. (USA - J Surg Res.).


Concurrent Optical- and Magnetic-Stimulation-Induced Changes on Wound Healing Parameters, Analyzed by Hyperspectral Imaging: An Exploratory Case Series - Mdpi.com
Article by Jürg Traber, Thomas Wild, Jörg Marotz, Martin C. Berli and Alfredo Franco-Obregón (Switzerland, Germany, Singapore - Bioengineering). This study showed that COMS therapy as an adjunct to SOC had a positive short-term effect on inflammation and tissue oxygenation in chronic wounds of various etiologies. These results further supported the body of evidence for safety and effectiveness of COMS therapy as a treatment option, especially for stagnant wounds that tended to stay in the inflammatory phase and required efficient phase transition towards healing.


The Role of Hyaluronan in Skin Wound Healing - Springer.com
Abstract by Yan Wang and Edward V. Maytin (Cleveland, USA - Hyaluronan).


Nursing students' skills in applying short-stretch compression bandages using the control of compression bandaging score - PubMed
Abstract by Paul Bobbink, Géraldine Gschwind and Sebastian Probst (Switzerland, Ireland - Br J Nurs.).


Use of Negative Pressure Wound Therapy for the Treatment of Venous Leg Ulcers - Hmpgloballearningnetwork.com
Article by Callie Horn, Allegra Fierro and John C. Lantis II (New York, USA). This review first examines the documented and potential VLU wound environment changes that can be facilitated by NPWT. The data supporting the use of NPWT for VLU wound bed preparation, the management of fluid drainage, and the bolstering of skin grafts are evaluated.


Getting wound care right: evaluation of a week of intensive teaching on wound care for undergraduate nursing students - Magonlinelibrary.com
Abstract by Melanie Stephens, Matthew Wynn, Sheba Pradeep, Karolina Staniecka, Anna Gill, Erin Brown and Charlotte Matthew (Salford, UK - British Journal of Nursing).


The Effect of Clinical Frailty on Wound Healing in Patients With Chronic Limb-Threatening Ischemia - PubMed
Abstract by Kunihiko Nishian, Masashi Fukunaga, Machiko Nishimura, Reiko Fujiwara and Daizo Kawasaki (Osaka, Japan - J Endovasc Ther.).


Xylazine: Substance Abuse and Wound Care - Woundsource.com
Article by Lauren Lazarevski (Buffalo, USA). In addition to the substance’s adverse effects on the central nervous system, xylazine use often causes severe cutaneous and necrotic wounds due to its vasoconstrictive properties.


Diabetic Wound Healing: Preclinical and Clinical Studies - Liebertpub.com
Abstract by Anna Herman and Andrzej P. Herman (Poland - Advances in Wound Care).


Platelet-rich plasma improves acute and chronic anal fissure, a randomized control trial - PubMed
Abstract by Hamed Ebrahimibagha and Adel Zeinalpour (Tehran, Iran - Wound Repair Regen.).


Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds - Biomedcentral.com
Article by Yuan Cai, Fang Zhang, Jingwei Feng, Bihua Wu, Hai Li, Shune Xiao, Feng Lu, Zairong Wei and Chengliang Deng (China - Stem Cell Research & Therapy). The authors' results indicate that it is safe, effective, and lasting in effect to treat chronic wounds with SVF-gel and mechanisms of action that include secreting various cytokines and promoting cell proliferation and migration ability.


Ultrasound in Wound Healing - Physio-pedia.com
Therapeutic ultrasound is utilized by physical therapists to deliver a high frequency mechanical vibration to facilitate healing at a cellular level. Therapeutic ultrasound is often used by physiotherapists to reduce pain, increase circulation and increase mobility of soft tissues.


HOXA3 accelerates wound healing in diabetic and aged non-diabetic mammals - Nature.com
Article by K. Parella, K. Moody, D. Wortel, H. Colegrove and J. A. Elser (USA - Scientific Reports). Whether as a plasmid or future alternative modality, topical HoxA3 is an attractive translational candidate for chronic wounds.


The Role of Neutrophils in Biomaterial-Based Tissue Repair – Shifting Paradigms - Mdpi.com
Article by Ana Beatriz Sousa and Judite N. Barbosa (Porto, Portugal - JFB). In this review, the authors focus on the roles of neutrophils in the resolution of the inflammatory response, in biomaterial–tissue integration and in the subsequent tissue repair/regeneration.


Effects of inpatient rehabilitation in leg lymphedema: a naturalistic prospective cohort study with intra-individual control of effects - PubMed
Abstract by Felix Angst, Thomas Benz, Susanne Lehmann, Peter S Sándor and Stephan Wagner (Bad Zurzach, Switzerland - Arch Phys Med Rehabil.).


Two-Pronged Microbe Delivery of Nitric Oxide and Oxygen for Diabetic Wound Healing - PubMed
Abstract by Huan-Huan Chen, Fang-Sheng Fu, Qi-Wen Chen, Yun Zhang and Xian-Zheng Zhang (Wuhan, China - Nano Lett.)


Pushing Through: How Older Adult Caregivers Manage Wound Care - PubMed
Abstract by Kristen L Swartzell, Janet S Fulton and Jane R von Gaudecker (Indianapolis, USA - West J Nurs Res.).


Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity - Wiley.com
Abstract by Huifeng Wang, Chongwen Duan, Rebecca L. Keate and Guillermo A. Ameer (Evanston, USA - Advanced Healthcare Materials).


Bacterial exclusion and wound healing potential of horizontal platelet-rich fibrin (H-PRF) membranes when compared to 2 commercially available collagen membranes - Springer.com
Article by Yun Qiu, Shanying Bao, Hongjiang Wei, Richard J. Miron, Senzhu Bao, Yufeng Zhang and Yulan Wang (China, Switzerland - Clinical Oral Investigations). H-PRF membranes exhibited better barrier function towards S. aureus over 2 days of innoculation and better wound healing ability when compared to two commercially available collagen membranes.


Chronic wound healing using glass - Newswise.com
Scientists at the University of Birmingham have proven that the antimicrobial effectiveness of silver lasts longer when incorporated into 'bioactive glass'. Additionally, they have successfully revealed how this innovative pairing provides superior and enduring wound protection against traditional options.


Examining Albumin as a Bioindicator of Healing Capability in Patients With Diabetic Foot Ulcers: A Retrospective Review - Hmpgloballearningnetwork.com
Article by Lucian G. Vlad, Joshua A. Grosser, Kristen A. Dodenhoff, Abigail E. Peoples, Gabriela Aguilo-Seara and Joseph A. Molnar (Winston-Salem, USA - Wounds). Albumin’s utility as a bioindicator of short-term healing capability is limited to below-normal values.


Methotrexate-associated Lymphoproliferative Disorder Presenting as an Ulcer With Tendon Exposure on the Dorsum of the Hand: A Case Report and Literature Review - Hmpgloballearningnetwork.com
Article by Haruka Kawamoto, Keisuke Shimbo and Isao Koshima (Hiroshima, Japan - Wounds). Although MTX-LPD with ulceration is rare, it should be considered in cases of refractory ulcers in patients with RA.


Electrochemical Devices in Cutaneous Wound Healing - Mdpi.com
Article by J. Parker Evans and Chandan K. Sen (Indianapolis, USA - Bioengineering). In this review, electroceuticals are organized into three mechanistic classes: ionic, wireless, and battery powered.


Characteristics of Fetal Wound Healing and Inspiration for Pro-healing Materials - Springer.com
Article by Sanika Pandit, Kimberly Nellenbach and Ashley C. Brown (Raleigh, USA - Biomedical Materials & Devices). This review addresses the key differences between adult and fetal wound healing that allow for enhanced scarless fetal healing and discusses how these differences can be used to develop pro-healing materials.


Post-Treatment of Micro-Needling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models - Dovepress.com
Article by Katharina Weßollek, Yvonne Marquardt, Sylvia Wagner-Schiffler, Jens Malte Baron and Sebastian Huth (Aachen, Germany - Clinical, Cosmetic and Investigational Dermatology). The authors' findings can help to optimise the aftercare routine after micro-needling procedures and to shorten the downtime for the patient after treatment.


Use of Infrared Thermometry to Observe Temperature Variation Associated with the Healing Process in Wounds and Ulcers: TIHUAP Cohort Study Protocols - Mdpi.com
Article by Mercè Iruela Sánchez, Rosa García-Sierra, Rafael Medrano-Jiménez, Diana Bonachela-Mompart, Natalia Maella-Rius et al. (Spain - Healthcare). This study may represent a turning point for its introduction into primary care. Early diagnosis of wound complications would facilitate treatment decision-making for healthcare professionals, thus improving the management of resources related to chronic wounds.


Pseudomonas Wound Infection: What Is It and What Are the Signs? - Woundsource.com
Article by Emily Greenstein. Pseudomonas aeruginosa (PA) is a common gram-negative aerobic bacilli bacterial infection in chronic wounds. PA is often present in soil, water, humans, and on the surface of medical devices, plants, and animals. PA is an opportunistic infection that can cause serious disease.


Multidisciplinary Care: How Vital Is Communication - Woundsource.com
Scott Bolhack discusses the importance of communication across care settings. Through the "Wound Provider Checklist" he presented at SAWC Spring 2023, Dr. Bolhack hopes this tool simplifies the complexities of patient transition through care.


Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle - PubMed
Abstract by Nurul Jannah Mohamed Nasir, Hans Heemskerk, Julia Jenkins, Nur Hidayah Hamadee, Ralph Bunte and Lisa Tucker-Kellogg (Singapore - Elife).


Immune Fitness, Migraine, and Headache Complaints in Individuals with Self-Reported Impaired Wound Healing - Dovepress.com
Article by Jessica Balikji, Marlou Mackus, Johan Garssen, Maarten M Hoogbergen and Joris C Verster (The Netherlands, Australia - International Journal of General Medicine). Headaches and migraines are more frequently reported by individuals with self-reported impaired wound healing, and their reported immune fitness is significantly poorer compared to healthy controls. These headache and migraine complaints significantly limit them in their daily activities.


Lymphedema Treatment Act: Where Are We At? - Woundsource.com
Article by Janet Wolfson. Lymphedema is a disease that "increase[s] [the] collection of lymphatic fluid in the body" and leads to swelling. It is crucial to treat and manage lymphedema because, when it is not diagnosed, treated, and managed in its early stages, it can affect the patient's skin and tissue and may impact other health issues, too.


Hospital-Acquired Pressure Injuries: Strategies for Prevention - Woundsource.com
In this interview, Kelly McFee discusses setting up a pressure injury prevention program at her facility with a focus on multidisciplinary efforts, along with resources that helped move this initiative along.


How to Identify Pressure Injuries in Skin of Color - Woundsource.com
Article by Janet Wolfson. The National Pressure Injury Advisory Panel published new guidelines in 2020 on the assessment of skin of color to improve the capture of pressure injuries (PI)—especially stage 1 and unstageable pressure injuries. Of course, pain can be an indicator for sensate patients. Medium to darkly pigmented skin can be easily obscured in visual skin assessments due to the presence of callus, dry or ashy skin, and dim lights.


The Use of Hydrogel Dressings in Sulfur Mustard-Induced Skin and Ocular Wound Management - Sciencedirect.com
Article by Fanny Caffin, David Boccara and Christophe Piérard (France, Biomedicines). Authors review how hydrogel dressings may be beneficial for improving the wound healing of sulfur mustard-induced injuries, with special emphasis placed on their suitability as drug delivery devices on SM-induced skin and ocular lesions.


Delivery of antibacterial agents for wound healing applications using polysaccharide-based scaffolds - Sciencedirect.com
Article by Hamed Nosrati, Morteza Heydari, Zahra Tootiaei, Saeid Ganjbar and Mohammad Khodaei (Iran, Germany - Journal of Drug Delivery Science and Technology). This review focuses on antibacterial nanobiomaterials and agents, as well as their delivery via polysaccharide-based scaffolds for wound healing applications.


Strategies to Target Microbial Attack in Chronic Skin Wounds: From Classic to Innovative Approaches - Sciencedirect.com
Article by Cláudia S. Oliveira and Rossella Laurano (Portugal, Italy - Bioenginereeing). Naturally derived compounds, and properly engineered biomaterials have received special attention as antimicrobial alternatives due to their beneficial biological outcomes (i.e., anti-inflammatory properties and their capability to reduce oxidation and microbial invasions).


Topical Insulin as an Add-On Therapy for Leg Ulcer: A Case Report - Cureus.com
Article by Yusuf Can Edek, Elif Çalışkan Güneş, Hale Nur Ertugay Aral, Esra Adışen and Ahmet Burhan Aksakal (Ankara, Turkey - Cureus). The use of topical insulin as an add-on therapy may reduce treatment time and speed up wound healing. Topical insulin can be considered as an additional therapy for treatment-resistant ulcers.