Hungarian Wound Care Society

Advances in Gas Therapeutics for Wound Healing: Mechanisms, Delivery Materials, and Prospects - Wiley.com
Article by Jiayi Ding, Kang Xu, Hongtao Xu, Jiansong Ji, Yuna Qian and Jianliang Shen (China - Small Structures). The characteristics of gas molecules with therapeutic functions, such as oxygen, nitric oxide, carbon monoxide, hydrogen sulfide, and others (such as sulfur dioxide, hydrogen, carbon dioxide, and plasma) in wound healing are introduced.

Effect of Blood Gel Derivatives on Wound Healing in Mouse Injured Tissue Models - Mdpi.com
Article by by Tuyet Thi Vi Le, Hoang Minh Lam, My Thi Ngoc Nguyen, Nghia Thi Hieu Phan et al. (Ho Chi Minh City, Vietnam - Gels). It can be concluded that platelet-rich fibrin lysate promotes wound healing in mouse injured tissue models in vitro, which can act as healing products in tissue repair.

Primary Care Disease Management for Venous Leg Ulceration in German Healthcare: Results of the Ulcus Cruris Care Pilot Study - PubMed
Abstract by Jonas D Senft, Thomas Fleischhauer, Regina Poß-Doering, Jona Frasch, Manuel Feißt, Sinclair Awounvo, Uwe Müller-Bühl, Attila Altiner, Joachim Szecsenyi and Gunter Laux (Germany - Healthcare (Basel)).

Moisture-Associated Skin Damage and Incontinence-Associated Dermatitis: Etiology, Diagnosis, and Management Strategies - Woundsource.com
Article by Dimitri Beeckman. Some reports indicate that 50% of patients with incontinence suffer from incontinence-associated dermatitis, a subcategory of moisture-associated skin damage.

Treatment of superficial and deep partial width second degree burn's wound with allogeneic cord blood platelet gel - PubMed
Abstract by Mohammad Ali Nilforoushzadeh, Elham Torkamaniha, Mostafa Dahmardehei, Mohammad Amir Amirkhani et al. (Iran, Canada - Skin Res Technol.).

Application of double-tube negative pressure drainage in repair of refractory wounds - PubMed
Abstract by Qing-Qing Sun, Lei Yan, Jia Cai and Hong-Bo Zhan (Jingjiang, China - Skin Res Technol.).

Medical Mythology, Misconceptions, and Misinformation: Does Iodine Impede Wound Healing? - Hmpgloballearningnetwork.com
Article by Christopher Girgis, Mehmet A. Suludere, Peter Andrew Crisologo and Lawrence A. Lavery (Wounds). Both cadexomer iodine (CI) and povidone-iodine (PI) appear to be safe, with no evidence that these products impede wound healing, are associated with more infections, or require more amputations compared with other modalities. PI can effectively be used for short periods of time, and CI is an effective wound care modality for chronic wounds.

Microbiome of the skin: The good and the bad - Openaccessgovernment.org
Chronic wounds are a significant burden to patients and health systems; Manuela Martins-Green from the University of California tells how her research in understanding the dynamics of wound healing could aid new approaches to wound care.

Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats - Mdpi.com
Article by Anna Carolo, Luca Melotti, Giulia Zivelonghi, Roberta Sacchetto, Eylem Emek Akyürek, Tiziana Martinello, Andrea Venerando, Ilaria Iacopetti, Michela Sugni, Giordana Martinelli et al. (Italy - Marine Drugs). The two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT.

Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds - Sciencedirect.com
Article by Pooya M. Tehrany, Parham Rahmanian, Aryan Rezaee, Golnaz Ranjbarpazuki, Farima Sohrabi Fard, Yasaman Asadollah Salmanpour, Mohammad Arad Zandieh et al. (Malaysia, Iran, Canada, USA - Environmental Research). This review sheds light on the biological functionalities of hydrogels, encompassing their role in modulating diverse mechanisms and cell types, including inflammation, oxidative stress, macrophages, and bacteriology.

Silicone adhesive multilayer foam dressings for preventing facial pressure injuries in COVID-19 patients in prone position - PubMed
Abstract by Pia Otto, Tobias Großkreutz and Stefan Köberich (Freiburg, Germany - J Intensive Care Soc.).

Effective and clinically relevant optimisation of cushioning stiffness to maximise the offloading capacity of diabetic footwear - PubMed
Abstract by Panagiotis E Chatzistergos, Alfred Gatt, Cynthia Formosa, Jonathan K Sinclair and Nachiappan Chockalingam (UK, Malta - Diabetes Res Clin Pract.).

Outcome Evaluation of Burn Injury Management: A Study of Selective Traditional Home Remedies - Cureus.com
Article by Ziyad Alharbi, Eyas Farran, Jumana Akbar, Orjowan Abid and Zain Albukhari (Jeddah, Saudi Arabia - Cureus). The safest and most effective initial management for burns among all the reviewed remedies was the application of cool running water, followed by seeking medical attention for evaluation and proper treatment, whereas tomato paste had a markedly poor effect.

A system for bioelectronic delivery of treatment directed toward wound healing - Escholarship.org
Article by Maryam Tebyani, Narges Asefifeyzabadi, Tiffany Nguyen, Cristian Hernandez, Kan Zhu, Li Kan et al.: Authors present a wearable bioelectronic system comprised of a polydimethylsiloxane (PDMS) device cast in customizable 3D printed molds and a printed circuit board (PCB), which employs commercially available engineering components and tools throughout design and fabrication.

Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial - Biomedcentral.com
Article by Masoumeh Roohaninasab, Fariba Khodadad, Afsaneh Sadeghzadeh-Bazargan, Najmolsadat Atefi, Sona Zare, Alireza Jafarzadeh, Seyyedeh Tahereh Rahimi et al. (Tehran, Iran - Stem Cell Research & Therapy). The results confirm the efficacy of SVF injection in combination with fractional CO2 laser in the treatment of burn scars and can be considered as a treatment option for better management of these lesions.

Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling - Nature.com
Article by Shinyo Ishi, Emi Kanno, Hiromasa Tanno, Shiho Kurosaka, Miki Shoji, Toshiro Imai, Kenji Yamaguchi, Kanna Kotsugai, Momoko Niiyama et al. (Japan - Scientific Reports). The authors' results indicate that the topical administration of KB131 accelerates wound healing, accompanying increased M2 macrophages, which suggests that CARD9 may be involved in these responses.

Genomic Biomarkers Can Provide a Deeper Understanding of Recurrent Pressure Injuries - Lww.com
Article by Letitia Y Graves, Katelyn R Schwartz, Josie Shiff, Ernest R Chan, Marinella Galea, Mary K Henzel, Christine Olney and Kath M Bogie (USA - Adv Skin Wound Care). Genomic biomarkers may complement electronic health records to support management of complex interactive health issues such as risk of recurrent PIs in people with SCI. These findings may also be leveraged for homogeneous phenotypic grouping of higher-risk individuals.

Management of diabetic foot ulcers: a narrative review - PubMed
Abstract by Jahyung Kim, Otgonsaikhan Nomkhondorj, Chi Young An, Ye Chan Choi and Jaeho Cho (Korea - J Yeungnam Med Sci.).

Comparative Clinical Study of Suprathel® and Jelonet® Wound Dressings in Burn Wound Healing after Enzymatic Debridement - Mdpi.com
Article by Wolfram Heitzmann, Mitja Mossing, Paul Christian Fuchs, Jan Akkan, Harun Seyhan, Gerrit Grieb, Christian Opländer and Jennifer Lynn Schiefer (Germany - Biomedicines). The authors found that both wound dressings could be used to achieve safe and rapid wound healing after the enzymatic debridement of deep dermal burns of the hands and feet. However, compared to Jelonet®, Suprathel® showed superior results in terms of patient comfort and pain reduction.

Interface pressure: what does it mean in clinical practice? - Wounds-uk.com
Article by Jacqui Fletcher. The use of interface pressure either as single peak readings or pressure maps is not a reliable way to help select equipment for whole organisations or specific departments. Reliance on these readings for the purpose of tendering should be urgently reviewed, and more subtle and clinically relevant measures which consider the range of mechanical forces, and the real-world application of the surfaces, should be used.

PICO™ Single Use Negative Pressure Wound Therapy (sNPWT) non-healing wound clinical practice pathway - Wounds-uk.com
Article by Andrew Sharpe. The implementation of the pathway has resulted in the patient receiving appropriate treatment at an earlier point than when conventional methods have been used. The pathway can be seamlessly integrated with existing pathways, such as MDFS pathways, providing staff with the necessary confidence, experience and competence for sustainable change.

Management of a fistula in the open abdomen - Wounds-uk.com
A fistula is an abnormal connection between two body parts. Patients may develop an enterocutaneous fistula following bowel surgery when the abdomen is left open. Managing these patients is complex and requires a multifaceted approach. Some of the issues are discussed and a patient case is presented in the following paper. Difficulties around managing the wound in particular are highlighted. Negative pressure wound therapy (NPWT) options are considered as well as other dressing choices.

Frugal innovation in wound management within a low resource inpatient setting: a case series - Wounds-uk.com
Article by Angela Mugumba, Augustine Seemujiu, Becky Maskew, Derek Bahandagira, Jane Boardman et al. This article highlights challenges of wound care in low resource settings, considering opportunities for frugal innovation and the authors' experiences while creating virtual wound care clinics across two global communities. In addition, authors will discuss four real cases presented within the virtual clinics.

Complex wound healing with topical negative pressure wound therapy: a case study - Wounds-uk.com
Article by Lisa Sutherland. Surgical wound dehiscence (SWD), a complication of surgery, can delay wound healing, increase the economic burden of the healthcare provider, and have a negative impact on the patient’s wellbeing. The fundamental goal for the treatment of SWD is wound closure. This article describes the use of Avance® Solo, a negative pressure wound therapy system, selected as a therapy for both the prevention and treatment of dehisced closed surgical incision wounds in a patient with complex and social needs.

What are the implications of the cost-of-living crisis on individuals with wounds? - Wounds-uk.com
Article by Samantha Holloway. The cost-of-living crisis is something that has been brought to the fore by reports such as the Royal Society for Public Health. This report highlights the immediate impact of the crisis on the health of individuals, as well as suggesting that a whole generation are at risk of poorer health. Furthermore, the report suggests that existing health inequalities are likely to become more apparent. For example, vulnerable populations, including lower-income individuals and marginalised communities, might be disproportionately affected, leading to disparities in access to services and therefore poorer outcomes.

The application of modified compression to prevent leg ulcer recurrence in the Republic of Ireland - Wounds-uk.com
Article by Claire Buckley, Nicole Muller, Siobhan Murphy and Yvonne Pennis. This research indicates that the application of modified compression to prevent the recurrence of VLU is limited within the clinical practice setting in Ireland, with inconsistency around.

Implementing an evidence-based pathway to improve outcomes for non-healing wounds - Wounds-uk.com
Article by Anita Kilroy-Findley and Karen Ousey. In order to provide structured and equitable interventions in relation to identification and management of wound infection, an NHS Trust has implemented an evidence-based pathway for non-healing wounds. Following the introduction of the pathway there were reduced nurse visits for wound assessment, a reduction in wound area, a reduction in necrotic tissue and improved healing rates.

Effect of closed incision negative pressure wound treatment in vascular surgery: A meta-analysis - Wiley.com
Article by Xiaohu Meng, Xupin Xie, Yongchang Liu, Changpin Huang, Linjun Wang, Xin Fang and Xumei Chen (Zhejiang, China - International Wound Journal). The examined data revealed that closed-incision NPW treatment had significantly lower infection rates, grade I infection rates, grade II infection rates, and grade III infection rates, surgical re-intervention, however, there were no significant differences in 30-day mortality, antibiotic treatment, or length of hospital stay compared to control group with vascular surgery.

New factors affecting wound healing and recurrence after pilonidal sinus surgery in adolescents; seborrheic dermatitis and psychiatric co-occurring conditions - Wiley.com
Article by Meltem Kaba (Istanbul, Turkey - International Wound Journal). As two new factors, the significance of the presence of seborrheic dermatitis and psychiatric comorbidities should be evaluated in these patients whose wounds remain open postoperatively and do not respond to primary wound care and eventually relapse. Further histologic and pathologic investigations are needed for seborrheic dermatitis and pilonidal sinus disease relation.

Iron Nanoparticles Open Up New Directions for Promoting Healing in Chronic Wounds in the Context of Bacterial Infection - Mdpi.com
Article by Zhaoyu Lu, Dong Yu, Fengsong Nie, Yang Wang and Yang Chong (Yangzhou, China - Pharmaceutics). Iron nanoparticles can serve clinical purposes not only to enhance wound healing but also to ameliorate anemia and glucose irregularities, capitalizing on iron’s properties. Iron nanoparticles positively impact the healing process of chronic wounds, potentially extending beyond wound management.

Why Do Diabetic Wounds Take Longer to Heal? A Breakthrough Study Explains - Gilmorehealth.com
Article by Mary Moore. Diabetic patients often grapple with delayed wound healing, with some wounds even becoming chronic. In extreme cases, these non-healing wounds can lead to the drastic measure of amputation. The precise reason behind this delay has remained an enigma for many years, but recent research has finally illuminated a significant contributing factor.

Allele-specific expression reveals genetic drivers of tissue regeneration in mice - PubMed
Abstract by Katya L Mack, Heather E Talbott, Michelle F Griffin, Jennifer B L Parker, Nicholas J Guardino, Amanda F Spielman, Michael F Davitt, Shamik Mascharak et al. (Stanford, USA - Cell Stem Cell).

A Historical Look at AI in Health Care - Woundsource.com
The use of Artificial Intelligence (AI) in health care is gaining significant attention and interest. AI is revolutionizing how providers diagnose, treat, and care for patients, but how did we get here? As wound care professionals, it is crucial to embrace these technological developments and understand their impact to ensure that your patients receive the best level of care possible.

Telangiectasia: Is it a Sign of Venous Insufficiency? - Woundsource.com
Article by Emily Greenstein. Telangiectasia, also known as "spider veins", is caused by permanent, abnormal dilation of end vessels, venules mainly, but also of capillaries and arterioles of the sub papillary plexus. It presents as red or blue tinted veins that are visible on the skin’s surface depending on if it is venous or arterial.

Vibrio vulnificus: What Are the Risks - Woundsource.com
Article by Shannon Solley. Although V. vulnificus has a high mortality rate, it is important to note that this infection is still relatively rare despite rising cases, especially when compared to other vibrio species. However, an understanding of V. vulnificus can prove valuable for wound care professionals located near the coasts where prevalence is rising.

Smart and versatile biomaterials for cutaneous wound healing - Biomedcentral.com
Article by Minxiong Li, Wenzheng Xia, Yi Min Khoong, Lujia Huang, Xin Huang, Hsin Liang, Yun Zhao, Jiayi Mao, Haijun Yu and Tao Zan (Shanghai, China - Biomaterials Research). By mapping the composition and intrinsic structure of smart responsive materials to their individual needs of cutaneous wounds, with particular attention to the responsive mechanisms, this review is promising to advance further progress in designing smart responsive materials for wounds and drive clinical translation.

The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts - Mdpi.com
Article by Philip Dueppers, Roland Bozalka, Reinhard Kopp, Anna-Leonie Menges, Benedikt Reutersberg, Claudia Schrimpf, Francisco Jose Moreno Rivero and Alexander Zimmermann (Zurich, Switzerland - JCM). Intact fish skin grafts have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief.

Multifunctional metal–organic frameworks for wound healing and skin regeneration - Sciencedirect.com
Article by Fei Xing, Hong Ma, Peiyun Yu, Yuxi Zhou, Rong Luo, Zhou Xiang, Pol Maria Rommens, Xin Duan and Ulrike Ritz (China, Germany - Materials & Design). The application of MOFs and their composites in wound healing was reviewed in this study. The physicochemical properties and porous structure in MOFs make them attractive in wound repair and skin regeneration.

Applications of Beehive Products for Wound Repair and Skin Care - Mdpi.com
Article by Simona Martinotti, Gregorio Bonsignore and Elia Ranzato (Alessandria, Italy - Cosmetics). This review characterizes the great potential of honeybee products in the field of health and skin care, considering that honey is a virtually inexhaustible natural resource which people, as bees have been domesticated over the centuries, can freely access.

Diabetic foot wound ulcers management by vacuum sealing drainage: A meta-analysis - Mdpi.com
Article by Liuqing Yang, Ning Zhao, Min Yang, Jiao Huang, Xiaomin Fu, Changjiang Lei and Pengzhu Cai (China - International Wound Journal). The examined data revealed that vacuum sealing drainage had significantly lower wound healing, duration of therapy and complication rates, as well as higher wound size reduction, compared with standard therapy in patients with diabetic foot ulcers.

Researchers develop a wearable bioelectronic system for wound healing treatment delivery - New-medical.net
Article by Pooja Toshniwal Paharia. In a recent study published in Scientific Reports, researchers presented a wearable bioelectronic system to deliver therapeutic agents associated with wound healing.

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review - Mdpi.com
Article by Egemen Umur, Emirhan Bayrak, Fahriye Arslan, Safiye Betül Bulut, Engin Baysoy, Gizem Kaleli-Can and Bugra Ayan (Turkey, USA - Applied Sciences). This review examines current state-of-the-art 3D bioprinting for hydrogel-based dressings, including both their advantages and limitations.

Low-Frequency Ultrasound Reinforces Silver Nanoparticles Effect in Experimental Chronic Non-healing Purulent Wounds Treatment - Springer.com
Abstract by Petro Myronov, Igor Duzhyi, Volodymyr Bugaiov, Viktoriia Holubnycha, Vladyslav Sikora, Anatoliy Opanasyuk, Anatolii Romaniuk, Oleksandr Pererva and Maksym Pogorielov (Ukraine, Latvia, Italy - BioNanoScience).

Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds - Nature.com
Article by Abigail L. Lauterbach, Rachel P. Wallace, Aaron T. Alpar, Kirsten C. Refvik, Joseph W. Reda, Ako Ishihara, Taryn N. Beckman, Anna J. Slezak, Yukari Mizukami, Aslan Mansurov, Suzana Gomes, Jun Ishihara and Jeffrey A. Hubbell (USA, UK - npj Regenerative Medicine). The authors demonstrate the design and characterization of an engineered recombinant interleukin-4 construct.

Utilization of Lyotropic Liquid Crystalline Gels for Chronic Wound Management - Mdpi.com
Article by Peili Luo, Lei Shu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan and Ping Hu (China - Gels). More reliable and applicable drug delivery systems should be designed and tested to improve the therapy and management of chronic wounds.

A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing - PubMed
Abstract by Jumin Yang, Xin Jin, Wenguang Liu and Wei Wang (China - Adv Mater.)

Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin - Nature.com
Article by Sara Rahati, Mohammad Kamalinezhad, Abdolali Ebrahimi, Mohammadreza Eshraghian and Hamideh Pishva (Iran - Scientific Reports). The authors' results indicate that, in regenerating diabetic ulcers, Spinacia oleracea may be effective. It influences the ulcer structure and speed.

Antimicrobial Wound Dressings: A Concise Review for Clinicians - Mdpi.com
Article by Faraz Yousefian, Roksana Hesari, Taylor Jensen, Sabine Obagi, Ala Rgeai, Giovanni Damiani, Christopher G. Bunick and Ayman Grada (USA, Grenada, Lybia, Italy - Antibiotics). This review covers the different types of antimicrobial dressings, their modes of action, advantages, and drawbacks, thereby providing clinicians with the knowledge to optimize wound management.

Simplified and modified Limberg flap plus vacuum-assisted closure for treatment of sacrococcygeal pilonidal sinus disease - Wiley.com
Article by Mingze Xu, Yuchong Wang, Xinyi Ma, Yanjun Liu, Chunyu Xue and Haiying Dai (Shanghai, China - International Wound Journal). Simplified modified Limberg flap reconstruction with vacuum-assisted closure surgery is an effective and innovative method for the treatment of pilonidal sinus disease (PSD), with a low recurrence rate and rapid recovery.

ROS-scavenging hydrogel to accelerate wound healing and reduce scar formation - Sciencedirect.com
Article by Xuedong Shu, Jun Shu, Yao Wang, Huan Deng, Junwei Zhang, Jing He and Fang Wu (Chengdu, China - Chemical Engineering Journal). The present approach furnishes new light on designing ROS-scavenging hydrogels with promising potential in chronic wound and less scar healing dressing applications.

Artificial Intelligence: Ethical and Privacy Considerations - Woundsource.com
With the rise of AI technology in medicine, clinicians and patients alike should be informed of modern-day privacy concerns and demand updated policy and legislation, particularly involving data ownership and access. AI will largely augment clinicians’ abilities to provide quality patient care. However, there are several ethical concerns that every clinician should carefully consider before implementing AI technology in their practice.

Prognostic models for clinical outcomes in patients with venous leg ulcers - A systematic review - PubMed
Abstract by Vladica M Velickovic, Tom Macmillan, Jan Kottner, Amy Crompton, Isobel Munro, Abby Paine, Jelena Savovic, Tim Spelman, Michael Clark, Harm Jaap Smit et al. (Austria, UK, Germany, The Netherlands - J Vasc Surg Venous Lymphat Disord.).

Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats - Nih.gov
Article by Zuyang Zhang, Tianhua Chen, Wei Liu, Jiepeng Xiong, Liangdong Jiang and Mingjiang Liu (Changsha, China - Korean J Physiol Pharmacol.). Paeonol accelerates the healing of diabetic ulcers by promoting M2 macrophage polarization and inhibiting M1 macrophage polarization.

Study sheds light on why wounds often heal poorly in diabetics - Eurekalert.org
When tiny particles called exosomes, which shuttle signals between cells, are defective in diabetic patients, they can drive inflammation and impair healing of wounds, according to a new Nano Today study led by University of Pittsburgh and UPMC researchers.

In Situ Forming Bioartificial Hydrogels with ROS Scavenging Capability Induced by Gallic Acid Release with Potential in Chronic Skin Wound Treatment - Mdpi.com
Article by Rossella Laurano, Alessandro Torchio, Gianluca Ciardelli and Monica Boffito (Italy - Gels). This work aimed at overcoming the criticism by formulating bioartificial hydrogels able to preserve the functionalities of the encapsulated scavenger (i.e., gallic acid) and expand its therapeutic window.

Personalised self-care for people with venous leg ulcers: a toolkit for change - Wounds-uk.com
Article by Andrew Kerr, Beth Kelly, Karen Ousey, Laura Hallas Hoyes, Leanne Atkin, Rhian Last, Stephanie Lowen and Zoe Chouliara. The guidance in this document aims to empower patients and improve outcomes, by equipping clinicians with a toolkit to effectively advocate for the inclusion of self-care, while potentially helping healthcare services to reduce the burden of wounds.

Breakthrough in scarless wound recovery achieved with autologous blood - Sciencedaily.com
A recent study has introduced a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants.

Osteopathic Approach for Keloids and Hypertrophic Scars - Cureus.com
Article by Bruno Bordoni, Allan R. Escher, Gregory T. Girgenti, Filippo Tobbi and Roberto Bonanzinga (Italy - Cureus). Reviewing the phases that allow the skin to be remodeled following an injury, this article reflects on the usefulness of resorting to these procedures, highlighting erroneous concepts on which the manual approach is based, compared to what the current literature highlights the cicatricial processes. Considering pathological scar adaptations, it would be better to follow a gentle manual approach.

Effect of tobacco usage on surgical site wound problems after primary total hip and total knee arthroplasty: A meta-analysis - PubMed
Abstract by Jiwen Zhu, Mengdi Si and Zongqiang Huang (Zhengzhou, China - Int Wound J.).

A brief note on stages of wound healing - Alliedacademies.org
Article by Maria Witte (Miami, USA - Journal of Dermatology Research and Skin Care). Understanding the stages of wound healing and their underlying mechanisms is crucial for promoting optimal recovery and minimizing complications.

Validating Wound Severity Assessment via Region-Anchored Convolutional Neural Network Model for Mobile Image-Based Size and Tissue Classification - Mdpi.com
Article by Yogapriya Jaganathan, Sumaya Sanober, Sultan Mesfer A Aldossary and Huda Aldosari (India, Saudi Arabia - Diganostics). The authors' outcomes highlight the effectiveness of the methodology in real-world scenarios and its potential to enhance therapeutic treatments for patients with chronic wounds.

Modelling the Effect of Matrix Metalloproteinases in Dermal Wound Healing - Springer.com
Article by Sonia Dari, Nabil T. Fadai and Reuben D. O’Dea (Nottingham, UK - Bulletin of Mathematical Biology). In this work, the authors develop a two-variable reaction-diffusion model, describing the interaction of matrix metalloproteinases (MMPs) with dermal cells in the wound healing process.

Modern Approaches in Wounds Management - Mdpi.com
Article by Simona-Maria Tatarusanu, Florentina-Geanina Lupascu, Bianca-Stefania Profire, Andrei Szilagyi, Ioannis Gardikiotis, Andreea-Teodora Iacob, Iulian Caluian et al. (Iasi, Romania - Polymers). The rational of using traditional hydrogels and SHs in wound healing, as well as the current research directions for developing SHs with innovative features, are addressed and discussed along with their limitations and perspectives in industrial-scale manufacturing.

Integrating factors associated with complex wound healing into a mobile application: Findings from a cohort study - Wiley.com
Article by Raquel Marques, Marcos Venícios Oliveira de Lopes, João Daniel Neves-Amado, Paulo Alexandre Silva Ramos, Luís Octávio de Sá, Irene Maria Silva da Oliveira et al. (Portugal - International Wound Journal). Integrating the identified risk factors for delayed healing into the assessment of patients and incorporating them into a mobile application can enhance decision-making in wound care.

Low-glucose culture environment can enhance the wound healing capability of diabetic adipose-derived stem cells - Biomedcentral.com
Article by Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu and Nai-Chen Cheng (Taiwan - Stem Cell Research & Therapy). In line with the literature, the authors' study showed that a diabetic milieu exerts an adverse effect on ASCs. Adopting LG culture condition is a simple and effective approach to enhance the wound healing capabilities of diabetic ASCs, which is valuable for the clinical application of autologous ASCs from diabetic patients.

Skin wound healing effects of (+)-syringaresinol from ginseng berry - Sciencedirect.com
Article by Jee-hyun Hwang, Yeonsoo Kang, Heui-Jin Park, Seolyeong Kim, Su-Hyun Lee, Hangun Kim, Sang-Jip Nam and Kyung-Min Lim (Korea - Journal of Ginseng Research). The authors demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.

Dehydrated human amnion/chorion membrane allograft with spongy layer to significantly improve the outcome of chronic non-healing wounds - Wiley.com
Article by Emmanouil Psathas, Bernhard Egger and Dieter Mayer (Fribourg, Switzerland - International Wound Journal). Treatment with dehydrated amnion/chorion membrane with a spongy layer improves the outcome of non-healing wounds of different aetiologies and, therefore, has to be considered early in the management of refractory wounds.

Biocompatible Cryogel with Good Breathability, Exudate Management, Antibacterial and Immunomodulatory Properties for Infected Diabetic Wound Healing - Wiley.com
Article by Yang Li, Zifeng Yang, Qi Sun, Ruijun Xu, Renjie Li, Dingcai Wu, Rongkang Huang, Feng Wang and Yong Li (Guangzhou, China - Advanced Science). The multifunctional cryogel effectively promotes collagen deposition and neovascularization, thus accelerating the healing of infected diabetic wounds.

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management - Mdpi.com
Article by Sabrina Prete, Marco Dattilo, Francesco Patitucci, Giuseppe Pezzi, Ortensia Ilaria Parisi and Francesco Puoci (Rende, Italy - JFB). The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.

Compare the effectiveness of extracorporeal shockwave and hyperbaric oxygen therapy on enhancing wound healing in a streptozotocin-induced diabetic rodent model - PubMed
Abstract by Rong-Fu Chen, Yun-Nan Lin, Keng-Fan Liu, Chia-Chun Lee, Chieh-Ju Hu, Chun-Ting Wang, Ching-Jen Wang and Yur-Ren Kuo (Taiwan, Singapore - Kaohsiung J Med Sci.).

Efficacy and Theoretical Basis of Low-Intensity Shock Wave Therapy in the Management of Different Forms of Wound Healing: Own Experiences and a Review of the Literature - Esmed.org
Article by Rassweiler J., Ringeisen M., Knobloch K. and Schaden W. (Austria, Germany - Medical Research Archives). ESWT presents a compelling non-invasive and safe treatment option for various wound healing challenges, improving outcomes for patients with chronic wounds and ulcers. This review highlights the potential of ESWT as an advanced wound healing therapy, complementing conventional approaches. Further studies should explore potentialdifferences between focal and radial ESWT for wound healing.

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review - Mdpi.com
Article by Varvara Vasalou, Efstathios Kotidis, Dimitris Tatsis, Kassiani Boulogeorgou, Ioannis Grivas, Georgios Koliakos, Angeliki Cheva, Orestis Ioannidis, Anastasia Tsingotjidou and Stamatis Angelopoulos (Thessaloniki, Greece - JCM). As wound healing remains a dynamic field, this narrative review provides a comprehensive overview of the current understanding and potential avenues for future research and clinical applications.

Biodiversity of Skin Microbiota as an Important Biomarker for Wound Healing - Mdpi.com
Article by Caglar Ersanli, Athina Tzora, Chrysoula (Chrysa) Voidarou, Stylianos Skoufos, Dimitrios I. Zeugolis and Ioannis Skoufos (Greece, Ireland - Biology). The authors discuss some important bacteria (coagulase-negative Staphylococci (CoNS), S. aureus, P. aeruginosa, and Lactobacilli) present in human skin, the effects of communication of bacteria with the immune system and epithelial cells on wound healing, and the identification techniques and manipulation strategies of the bacterial population in wounded skin tissue.

Time and labor costs of compression therapy wrap system for lower extremity edema: results from a single center - Hmpgloballearningnetwork.com
Article by Peter J Mallow, Debashish Chakravarthy and Louis Pilati (USA - Wounds). The use of a 2LB compression system may be associated with substantial time and cost savings compared to a 4LB system.

Effectiveness of zinc therapy for the treatment of pressure ulcers - PubMed
Abstract by Jessica Cazalilla Chica and James Edward Hill (UK - Br J Community Nurs.).