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News from the field of wound care and wound healing - November, 2023

Exosomes from adipose-derived stem cells restore fibroblast function and accelerate diabetic wound healing - Sciencedirect.com
Article by Chen Yang, Hao Zhang, Chen Zeng, Chenyang Tian, Wenjun Liu, Yuxi Chen et al. (China - Heliyon). This study indicated that ADSC exosomes alleviated high glucose induced damage to fibroblasts and accelerate diabetic wound healing by inhibiting Bax/caspase 3.


Fish Scale Gelatin Nanofibers with Helichrysum italicum and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings - Mdpi.com
Article by Carmen Gaidau, Maria Râpă, Maria Stanca, Mariana-Luiza Tanase, Laura Olariu et al. (Bucharest, Romania - Pharmaceutics). The wound-healing assay results indicated that fish scale gelatin nanofibers showed promising wound closure after 20 h of application, highlighting its regenerative potential on fibroblasts treated both under normal conditions and pro-inflammatory stimulated.


Reproducible strategy for excisional skin-wound-healing studies in mice - Nature.com
Abstract by Matan Yampolsky, Ido Bachelet and Yaron Fuchs (Rehovot, Israel - Nature Protocols).


Honey therapies for dermatological disorders: more than just a sweet elixir - Wiley.com
Article by Maya Jodidio and Robert A. Schwartz (Newark, USA - International Journal of Dermatology). This paper reviews the properties and components of honey that contribute to its wound-healing-based applications, the types of honey employed in medicine, and its dermatological applications. Based on the evidence from case reports, clinical trials, and in vitro studies, honey has been characterized as a safe, cost-effective, and readily available treatment option for many skin conditions, including microbial infections, atopic dermatitis, psoriasis, necrotizing fasciitis, ulcers, as well as thermal and other types of wounds.


Implanting mechanically reprogrammed fibroblasts for aged tissue regeneration and wound healing - Wiley.com
Article by Bibhas Roy, Tina Pekec, Luezhen Yuan and G. V. Shivashankar (Switzerland - Aging Cell). The authors' results provide a novel, nongenetic, partial reprogramming of aged cells for cell-based therapies in regenerative medicine.


Microneedle bandage offers new hope for diabetic wound treatment - News-medical.net
Article by Tarun Sai Lomte. In a recent study published in Nature Communications, researchers developed a microneedle bandage containing selenium and chlorin e6 hybrid nanoparticles (SeC@PA) for diabetic wound therapy.


Developing natural polymers for skin wound healing - Sciencedirect.com
Article by Han Zhang, Xiang Lin, Xinyue Cao, Yu Wang, Jinglin Wang and Yuanjin Zhao (China - Bioactive Materials). This review provides a comprehensive overview of prevalent natural polymers utilized in the biomedical domain throughout the preceding two decades.


Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds - Mdpi.com
Article by Nádia S. V. Capanema, Alexandra A. P. Mansur, Sandhra M. Carvalho, Talita Martins et al. (Brazil - Polymers). The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections.


Sensor-Assisted Wound Therapy in Plantar Diabetic Foot Ulcer Treatment: A Randomized Clinical Trial - PubMed
Abstract by Dirk Hochlenert, Can Bogoclu, Kevin Cremanns, Lars Gierschner, Dominik Ludmann et al. (Germany - J Diabetes Sci Technol.).


Wound Healing, Scarring and Management - PubMed
Abstract by Mahaveer S. Sangha, Florence Deroide and Rhonda Meys (London, UK - Clin Exp Dermatol.).


Microbiological Evaluation of Four Different Suture Materials Used for the Surgical Removal of Impacted Lower Third Molars: A Single-Center Prospective Comparative Study - Cureus.com
Article by Sai Krishna, Rajprakash Bhaskaran, Santhosh P. Kumar, Murugesan Krishnan and Saravanan Lakshmanan (Chennai, India). It was found that prolene and vicryl plus sutures exhibited superior microbiological properties compared to monocryl and silk sutures when used for the surgical removal of impacted lower third molars. The lower incidence and less quantity of bacterial colonization on prolene sutures suggest their potential for reducing the risk of postoperative infection; hence, these sutures can be preferred for oral surgical procedures.


Effects of photobiomodulation with blue Light Emitting Diode (LED) on the healing of skin burns - PubMed
Abstract by José de Alencar Fernandes Neto, Thamyres Maria Silva Simões, Tharcia Kiara Beserra de Oliveira et al. (Brazil - Lasers Med Sci.).


Renal function as risk factor for diabetic foot ulcers: A meta-analysis - Wiley.com
Article by Long Jin and Wenwen Xu (Zhejiang, China - International Wound Journal). The examined data revealed that diabetic foot ulcer (DFU) had significantly higher chronic renal failure, higher serum Creatinine, and a low estimated glomerular filtration rate compared to non-DFU patients with diabetes mellitus.


Retrospective comparison of postoperative dressing after eschar dermabrasion on paediatric scald wounds: Bacterial cellulose dressing and allogenic skin - Wiley.com
Article by Ran Zhao, Chenyuyao Zhao, Yushen Zhang, Yi Wan and Yibing Wang (Jinan, China - International Wound Journal). The authors' findings suggest that the bacterial cellulose material may serve as an optimal coverage option for paediatric abraded scald wounds.


Impact of ileostomy on postoperative wound complications in patients after laparoscopic rectal cancer surgery: A meta-analysis - Wiley.com
Article by Shu Yang, Yuting Lin, Wenjin Zhong, Wenji Xu, Zhongxin Huang, Suqin Cai, Wen Chen and Baogen Zhang (Quanzhou, China - International Wound Journal). The authors cautiously conclude that protective ileostomy is active and necessary for patients with a high risk of anastomotic leakage after surgery, which needs to be further confirmed by high-quality studies with larger samples.


Collagen Dressings Explored: A Closer Look At Their Role in Wound Care - Covalon.com
Collagen is one of the most plentiful proteins in the human body. Collagen is produced and used by the body to create connective tissue – and connective tissue is what our skin is made of, which is why collagen dressings are used to heal skin damage.


Diabetes and Wound Healing: What You Need to Know - Promedica.org
Article by Michelle Morris. Did you know that people with diabetes have a more difficult path to wound healing? This is because their body is not able to control the person’s blood sugar levels. When blood sugar is heightened for an extended period, it impacts the healthy function of the circulatory, nervous, and immune systems. All these factors impair the body’s ability to protect and heal itself.


Incidence of Pressure Injury Among Older Adults Transitioning from Long-term Care to the ED - PubMed
Abstract by Kaitlyn Tate, Simon Palfreyman, R Colin Reid, Patrick McLane and Greta G Cummings (Edmonton, Canada - Adv Skin Wound Care).


Is It Really Infected? Recognizing Infection in Diabetic Foot Ulcers Based on the Evidence - Woundsource.com
Article by Holly M. Hovan. It is important to differentiate among infection, inflammation, contamination, and colonization. Additionally, clinicians should rule out other etiologies (eg, dependent rubor versus true erythema of an extremity) and incorporate evidence-based guidelines into the treatment plan.


Comparing the traditional and emerging therapies for enhancing wound healing in diabetic patients: A pivotal examination - Wiley.com
Article by Chunfen Liao, Mingjie Zhu, Hongchen Ding, Yanli Li, Qianshu Sun and Xueqin Li (Shiyan, China - International Wound Journal). This study compared traditional therapies (TT) and emerging therapies (ET) for enhancing diabetic patients' wound healing. ET have demonstrated significant efficacy in accelerating wound healing in diabetic patients, surpassing traditional methods, with additional advantages in pain management and life quality.


Magnetic gel enables faster diabetic wound healing - Labonline.com.au
Diabetic patients, whose natural wound-healing capabilities are compromised, often develop chronic wounds that are slow to heal and can cause serious infections resulting in painful outcomes, including amputation. A research team led by the National University of Singapore (NUS) has now engineered an innovative magnetic wound-healing gel that accelerates the healing of diabetic wounds and reduces the rate of recurrence, which they have described in the journal Advanced Materials.


How the Identification of Chronic Wound Infection Can Be Improved With Technology - Woundsource.com
Article by Liping Tang. Infection is the single most likely cause of delayed healing in chronic wounds. Common signs of infection - pain, erythema, heat, and purulent exudate - vary as we age and occur differently in those with underlying diseases or weakened immune systems.


A Primer on Electrical Stimulation in Wound Management - Woundsource.com
Article by Jennifer Spector. At WoundCon Fall, Jeanine Maguire, PhD, MPT, CWS introduced the use of electrical stimulation (e-stim) as a modality in wound healing. She discussed key terminology, current parameters for use in the United States, and important considerations for all clinicians.


Pressure Injury Prevention - Hmpgloballearningnetwork.com
Approximately 2.5 million patients in the United States develop a pressure injury every year, and approximately 60,000 patients die directly from a pressure injury annually. Additionally, the cost of individual patient care ranges from $20,900 to $151,700 per pressure injury. However, it is estimated that 95% of pressure injuries are preventable.


A Primer on Electrical Stimulation in Wound Management - Woundsource.com
Article by Jennifer Spector. At WoundCon Fall, Jeanine Maguire, PhD, MPT, CWS introduced the use of electrical stimulation (e-stim) as a modality in wound healing. She discussed key terminology, current parameters for use in the United States, and important considerations for all clinicians.


MRSA: The Basics - Woundsource.com
Article by Cathy L. Harmon. The most important factor in the prevention of MRSA is proper utilization of antibiotics. Overuse of antibiotics contributes to MRSA. Always make sure that an antibiotic is warranted prior to prescribing and review the amount, type, and time span of antibiotics taken in the past. Advise patients to complete any prescribed antibiotics. MRSA infections usually clear with time and treatment.


Stop Saying Non-Compliant: A Guide to Strengthening the Clinician-Patient Relationship - Woundsource.com
Article by Maria Goddard. There are differences in the health care space when discussing compliance versus adherence. The phenomenon of patients not following medical advice is not new, but it has significant ramifications on morbidity and mortality. Reports, mostly on medication regimens, estimate 125,000 yearly deaths from a lack of adherence to the prescribed plan.


The emerging progress on wound dressings and their application in clinic wound management - Sciencedirect.com
Article by Linlin Su, Yanhui Jia, Lanqing Fu, Kai Guo and Songtao Xie (China - Heliyon). The real-time and dynamic acquisition and analysis of wound conditions are crucial for wound management and prognostic evaluation. Therefore, the development of modern dressings that integrate multiple functions, have high similarity to the skin, and are highly intelligent will be the focus of future research, which could drive efficient wound management and personalized medicine, and ultimately facilitate the translation of health monitoring into clinical practice.


Enhanced cutaneous wound healing through MMP-8-responsive release of antimicrobial peptide from a porous chitosan-based scaffold - Sciencedirect.com
Article by C. L. Vipin, P. Priya, K. Harikrishnan and G. S. Vinod Kumar (Thiruvananthapuram, India - Journal of Drug Delivery Science and Technology). The results of this study suggest that the developed chitosan-based wound dressing could serve as an effective therapeutic strategy for wound management.


Optimizing Surgical Wound Care in Obstetrics and Gynecology - PubMed
Abstract by Julia R Salinaro, Penny S Jones, Amelia B Beatty, Sarah K Dotters-Katz, Jeffrey A Kuller and Nicole P Kerner (Durham, UK - Obstet Gynecol Surv.).


What's the true costs of wounds faced by different healthcare systems around the world? - Wiley.com
Article by Douglas Queen and Keith Harding (Canada, UK - International Wound Journal). For many wound carers globally getting a handle on the costs associated with the management of chronic wounds is difficult, if not impossible. There are some published figures geographically but most of these are not ‘standardised’ to permit comparison easily or directly. One consistent theme from a number of these studies, however, is that they relate the costs of wounds, extrapolated or otherwise, to the total geographic healthcare costs. This provides a percentage figure as a benchmark.


Changes in the quality of life of adults with an ostomy during the first year after surgery as part of the Best Practice Spotlight Organisation® Programme - Wiley.com
Article by Belén Martín-Gil, Noel Rivas-González, Teresa Santos-Boya, María López, José-María Jiménez, Natán Redondo-Pérez et al. (Valladolid, Spain - International Wound Journal). The aim was to analyse changes in the perceived quality of life of patients with an ostomy during the first year after surgery at two or three follow-ups. This is a prospective study of a cohort of 55 patients.


Utilizing the visual analogue scale (VAS) to monitor and manage pain in post-operative skin wounds after thoracic surgery - Wiley.com
Article by Mingyue Qu, Jialai Zhao, Yiling Zhang, Zigeng Xu, Chenguang Ma and Hanwen Cui (Harbin, China - International Wound Journal). The visual analogue scale (VAS) is a reliable method for evaluating post-thoracic surgery discomfort. Given the substantial impact of pain history on VAS scores, there is an urgent need for personalized pain management strategies to improve post-operative care.


An Overview of Recent Developments in the Management of Burn Injuries - Mdpi.com
Article by Elżbieta Radzikowska-Büchner, Inga Łopuszyńska, Wojciech Flieger, Michał Tobiasz, Ryszard Maciejewski and Jolanta Flieger (Poland - IJMS). Personalization and multidisciplinary collaboration are key to the successful management of burn patients. In this comprehensive review, they have collected and discussed the available treatment options, focusing on recent advances in topical treatments, wound cleansing, dressings, skin grafting, nutrition, pain and scar tissue management.


Promising improvement in infected Wound Healing in Type two Diabetic rats by Combined effects of conditioned medium of human adipose-derived stem cells plus Photobiomodulation - Biomedcentral.com
Article by Kaysan Sohrabi, Houssein Ahmadi, Abdollah Amini, Behnaz Ahrabi, Atarodalsadat Mostafavinia, Hamidreza Omidi, Mansooreh Mirzaei et al. (Iran - Laboratory Animal Research). PBM, h-ASC-COM, and h-ASC-COM + PBM treatments meaningfully accelerated the maturation phase of the wound restoration process in IIDWHM with MRSA in TIIDM rats by diminishing the inflammatory reaction, and the CFU of MRSA; and increasing wound strength, WCR, number of fibroblasts, and new blood vessels.


Bee gomogenat enhances the healing process of diabetic wounds by orchestrating the connexin-pannexin gap junction proteins in streptozotocin-induced diabetic mice - Nature.com
Article by Leila H. Sayed, Gamal Badr, Hossam El-Din M. Omar, Sary Khaleel Abd Elghaffar and Aml Sayed (Egypt - Scientific Reports). The authors' findings showed for the first time that bee gomogenat promotes the recovering process and accelerated the closure of diabetic related wounds.


Graft-Host Interaction and Its Effect on Wound Repair Using Mouse Models - Mdpi.com
Article by Nicole Garcia, Md Mostafizur Rahman, Carlos Luis Arellano, Ilia Banakh, Chen Yung-Chih, Karlheinz Peter et al. (Melbourne, Australia - IJMS). The authors have shown how stages of spontaneous wound repair are influenced by autologous skin grafting. Moreover, they have identified significant differences in wound repair pathway activation when wounds are grafted with a synthetic graft compared with autologous FTSG. The long-term goal of this study is to identify biomarkers that can predict healing and scarring outcomes post-grafting. Graft take and scarring biomarkers are useful tools to assist in novel and efficacious engineered graft designs and/or graft outcomes.


How Transdermal Probiotics Revolutionize Wound Healing - Tomorrow.bio
The potential benefits of transdermal probiotics are undeniable. As more scientific evidence emerges, we can expect to see their integration into mainstream wound healing practices, ultimately revolutionizing the way we approach and treat wounds.


New wound healing research by Wake Forest Institute for Regenerative Medicine produces full-thickness human bioprinted skin - Bizjournals.com
A research paper published in Science Translational Medicine presents a significant breakthrough in the area of skin regeneration and wound healing by researchers at the WFIRM.


Traumatic, Full-Thickness Wounds: How an Advanced Dressing Can Help - Woundsource.com
Article by Shannon Solley. A study from 2021 on the correlation between trauma wound severity and infection rates found an infection prevalence of 6% of the 150,948 patients in the study. Of those with infection, approximately 10% had a greater mortality rate in the hospital than those without infection.


Mucosal Membrane Pressure Injuries - Woundsource.com
The incidence and prevalence of mucosal membrane PIs are reported as relatively low, but these injuries are more common in the intensive care unit (ICU) than in acute hospital care. One study reported an incidence of hospital-acquired mucosal membrane PIs of 0.1% in a non-ICU setting and an incidence of 2.4% in the ICU.


Novel Microneedle Platforms for the Treatment of Wounds by Drug Delivery: A Review - Sciencedirect.com
Article by Heng An, Zhen Gu, Zhe Huang, Tong Huo, Yongxiang Xu, Yaozhong Dong and Yongqiang Wen (Beijing, China - Colloids and Surfaces B: Biointerfaces). The development of microneedles in external wound repair and management is envisioned, and it is hoped that this study can provide guidelines for the design of microneedle systems in different application contexts, including the selection of materials, preparation methods, and structural design, to achieve better healing and regeneration results.


Efficacy of wearable vibration dressings on full-thickness wound healing in a hyperglycemic rat model - PubMed
Abstract by Daijiro Haba, Takafumi Ohmiya, Masaki Sekino, Qi Qin, Chihiro Takizawa, Sanai Tomida, Takeo Minematsu, Hiromi Sanada and Gojiro Nakagami (Tokyo, Japan - Wound Repair Regen.).


Maggot debridement therapy stimulates wound healing by altering macrophage activation - Wiley.com
Article by Xin-Juan Sun, Jin-An Chen, Gai Li, Lei Wang, Tian-Yuan Wang and Ai-Ping Wang (Nanjing, China - International Wound Journal). Maggot debridement therapy interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.


Oxygen-Generating Patch Accelerates Wound Healing - Healthcarepackaging.com
Article by Tim Hayes. Scientists at Incheon National University in Korea have developed a new adhesive patch for wound healing that generates oxygen, addressing the limitations of traditional wound closure methods like sutures and staples. The patch is made of gelatin-based oxygen-generating tissue adhesives (GOTs) that release oxygen to promote healing. The innovation offers better control of adhesion, mechanical properties, and drug delivery, improving coagulation, blood closure, and tissue regeneration.


Nanomaterials for wound healing: Current status and futuristic frontier - Sciencedirect.com
Article by J. Nandhini, E. Karthikeyan and S. Rajeshkumar (Chennai, India - Biomedical Technology). The safety and effectiveness of nanomaterials depend on further investigation into their design, interactions with biological systems, and the results of rigorous preclinical and clinical trials. There is great potential for a dramatic improvement in patient outcomes with the introduction of nanomaterial-based wound healing therapies.


Chitosan sponges loaded with metformin and microalgae as dressing for wound healing: A study in diabetic bio-models - Sciencedirect.com
Article by Laura Vazquez-Ayala, César Del Ángel-Olarte, Diana María Escobar-García, Sergio Rosales-Mendoza et al. (San Luis Potosí, Mexico - International Journal of Biological Macromolecules). In vivo wound healing evaluation showed that metformin-loaded chitosan sponges regenerated skin tissue after 21 days of treatment, highlighting the rate of healing provided when exopolysaccharide was added to promote tissue regeneration, which can be corroborated by histological analysis. These results make chitosan sponge compounds promising dressings for diabetic foot wound treatment.


Expanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue Regeneration - Mdpi.com
Article by Beatriz G. Bernardes, Sara Baptista-Silva, Carlos Illanes-Bordomás, Rui Magalhães et al. (Portuga, Spain - Pharmaceutics). The in vitro assessment using human dermal fibroblasts confirm the particles’ biocompatibility, as well as the enhancement in cell viability and proliferation.


Effects of pneumatic compression therapy on wound healing in patients with venous ulcers: A meta-analysis - Wiley.com
Article by Qiuxiang Xu and Zhuanzhuan Li (Taiyuan, China - International Wound Journal). Current evidence suggests that the effects of pneumatic compression therapy on wound healing rates, changes in wound area, and the incidence of adverse events in patients with venous ulcers are similar to those of bandage pressure therapy.


Quantitative evaluation of the low-temperature pulsed plasma-wound interaction based on splint model - Aips.org
Article by Yongqiang Fu, Deqiang Kong, Xinyu Gu, Yuting Wang, Yaojiong Wu and Ruobing Zhang (Shenzhen, China - Applied Physics Letter). The MEWS model adopted in this experiment reduces the interference in the evaluation of the wound healing effect caused by skin contraction and wound dressing, and thus is closer to the healing process of human wounds, and the method of wound area acquisition and calculation based on image processing reduces human interference and is more standardized, which can be used to evaluate the effect of the pulsed low-temperature plasma jet on promoting wound healing.


Comparing the Effectiveness of Glucocorticoids in Preventing Hypertrophic Scar Diagnosis in Burn Patients - Mdpi.com
Article by Alejandro Joglar, Juquan Song, George Golovko, Jayson Jay, Steven Wolf and Amina El Ayadi (Galveston, USA - Medicina). While glucocorticoids are one of the mainstay treatments for hypertrophic scarring, further studies are needed to determine early therapeutic interventions that will reduce the potential for hypertrophic scar development in burn patients.


Ultrasound in paediatric surgery: A meta-analysis review of its influence on postoperative wound healing and infection rates - Wiley.com
Article by Yinghui Peng, Qianjun Liu, Ju Tang, Mengjie Zhou, LingPing Liu and Jinqiao Liu (Changsha, China - International Wound Journal). The authors' findings underscore the potential benefits of US in enhancing postoperative wound healing and reducing infection rates in paediatric surgical settings. However, the application of US should be judicious, considering the nuances of individual patient needs and clinical contexts.


In vitro and in vivo evaluation of alginate hydrogel-based wound dressing loaded with green chemistry cerium oxide nanoparticles - Frontiersin.org
Abstract by Ran Zhao, Chenyuyao Zhao, Yi Wan, Syed Qamar Abbas and Yibing Wang (China, Pakistan - Front. Chem.).


Metal–Phenolic Networks for Chronic Wounds Therapy - Dovepress.com
Article by Danyang Wang, Jianfeng Xing, Ying Zhang, Ziyang Guo, Shujing Deng, Zelin Guan, Binyang He, Ruirui Ma, Xue Leng, Kai Dong and Yalin Dong (China - International Journal of Nanomedicine). This article will focus on the composition of metal–phenolic networks (MPNs), the mechanisms of MPNs for the treatment of chronic wounds, and the application of MPNs in novel chronic wound therapies.


Surgical Wounds: Understanding Complications - Woundsource.com
Treatment of surgical wound complications includes pain management, infection control, and management of wound drainage. More specifically, follow the surgeon’s orders, perform continued assessments and monitoring, adhere to prescribed treatment protocols (eg, dressing types and duration, staple, or suture removal), document findings, and communicate any concerns (eg, signs of infection or dehiscence).


Evaluation of Surgical Wounds - Woundsource.com
Successful care of surgical wounds begins with a comprehensive assessment of both the wound and the patient, including a clear understanding of the type and class of surgical wound. Psychosocial factors affecting healing and well-being, are essential to consider as well.


Evaluation of Negative Pressure Wound Therapy in the Management of Fournier’s Gangrene - Cureus.com
Article by Sushant Tanwar, Shivani B. Paruthy, Arun Singh, Vikas Pandurangappa, Deepak Kumar and Soni Pal (New Delhi, India). VAC therapy provides significant benefits in the management of FG, leading to improved clinical outcomes and patient quality of life. It offers advantages such as shorter hospital stays, faster wound closure, and reduced sepsis markers. The application of VAC dressing should be considered a valuable treatment modality for FG.


Shaping the Future of Antimicrobial Therapy: Harnessing the Power of Antimicrobial Peptides in Biomedical Applications - Mdpi.com
Article by Amit Kumar Tripathi, Jyotsana Singh, Rucha Trivedi and Payal Ranade (USA - JFB). The authors review the latest advancements in biomedical sciences and discuss the antimicrobial peptides that were immobilized successfully to enhance their efficacy and stability within the implant environment.


The flip-flops sandal sign: A semiotic evidence of chronic venous insufficiency in patients with stasis dermatitis - Wiley.com
Article by Guilherme Almeida Rosa da Silva, Walter A. Eyer-Silva and Marcelo Costa Velho Mendes de Azevedo (Rio de Janeiro, Brazil - International Wound Journal). Careful observation of the dorsal feet of users of flip-flops sandals may provide further clues to the clinical diagnosis of CVI. Treatment of stasis dermatitis includes the use of compression therapy by socks, endovenous thermal ablation, and sclerotherapy, which have supplanted the use of open surgical techniques.


Estimating the value of repositioning timing to streamline pressure injury prevention efforts in nursing homes: A cost-effectiveness analysis of the ‘TEAM-UP’ clinical trial - Wiley.com
Article by William V. Padula, Samuel A. Crawford, Susan M. Kennerly and Tracey L. Yap (USA - International Wound Journal). Facilities can use cost-savings recuperated from nursing time to deploy to other patient safety priorities without seriously jeopardizing pressure injury safety.


Risk factors for sternal wound infection after open-heart operations: A systematic review and meta-analysis - Wiley.com
Article by Dongsheng Chen, Jianghe Zhang, Yuting Wang, Weiqian Jiang, Yujian Xu, Chenlu Xiong, Zekun Feng, Yan Han and Youbai Chen (China - International Wound Journal). The detected risk factors significantly affected the wound healing process, but some were different in strength. Anything that affects wound healing and antibacterial ability, such as lack of oxygen, local haemodynamic disorders, malnutrition condition and compromised immune system will increase the risk, and this reminds us of comprehensive treatment during the perioperative period.


Good bacteria for bad wounds - Newswise.com
Millimeter by millimeter, new tissue makes its way through a wound until it has closed a skin lesion. Soon, in the best case, there is nothing left to see of a knee scrape, a finger cut or a burn blister. Not so with chronic wounds, though: If the injury has not healed after four weeks, there is a wound healing disorder. Sometimes, seemingly harmless tissue damage can develop into a permanent health problem or even blood poisoning.


Regeneration Therapy: The Role of Platelet-Rich Plasma in Post-hysterectomy Wound Dehiscence Healing - Cureus.com
Article by Shreya A. Sahu and Deepti Shrivastava (Wardha, India). It can be concluded that PRP is a novel method for wound healing for the patient in the post-hysterectomy period. The autologous nature of the PRP makes it of minimal danger to the patient in terms of associated complications.


Topical application of synthetic melanin promotes tissue repair - Nature.com
Article by Dauren Biyashev, Zofia E. Siwicka, Ummiye V. Onay, Michael Demczuk, Dan Xu, Madison K. Ernst, Spencer T. Evans, Cuong V. Nguyen, Florencia A. Son et al. (USA - npj regenerative medicine). Synthetic melanin particles are promising and effective candidates as topical therapies for accelerated wound healing, including via pathways validated in human skin.


The role of community pharmacy in wound care: a scoping review - PubMed
Abstract by Daisy Hk Cheung, Carl R Schneider and Irene S Um (Sydney, Australia - J Wound Care).


Innovative Magnetic Gel Heals Diabetic Wounds Three Times Faster - Hospimedica.com
Laboratory experiments demonstrated that the magnetic wound-healing gel, supported by increased fibroblast activity, not only boosted the cells’ growth rate by around 240 percent but also more than doubled their collagen production, an essential component for wound healing. Moreover, it facilitated better interaction between fibroblasts and keratinocytes, which is the key to forming new blood vessels.


Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing - Mdpi.com
Article by Hye-Jeong Jang, Daniel Manaye Tiruneh, Hanjun Ryu and Jeong-Kee Yoon (Korea - Biomimetics). The authors elucidate the fundamental mechanisms of wound healing and relevant bioelectric physiology, as well as the principles underlying each nanogenerator technology, and review their preclinical applications.


Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution - Nature.com
Article by Elizabeth E. L. Lee, Isabel O’Malley-Krohn, Eric Edsinger, Stephanie Wu and Jocelyn Malamy (USA - Scientific Reports). The authors' re-draw the P2XR evolutionary tree, provide new insights into the origin of eATP signaling in wound healing, and demonstrate that the cytoskeleton of submarginal cells is a target of eATP signaling.


Effect of different catheter pathways on wounds after minimally invasive radical prostatectomy: A meta-analysis - PubMed
Abstract by Tao Wang, Shiben Ji, Ci Zhang, Yang Xiang and Guohong Yin (Wuhan, China - Int Wound J.).


Retention of Key Characteristics of Unprocessed Chorion Tissue Resulting in a Robust Scaffold to Support Wound Healing - Mdpi.com
Article by Katrina A. Harmon, MaryRose Kammer, Justin T. Avery, Kelly A. Kimmerling and Katie C. Mowry (Birmingham, USA - IJMS). The authors' data support the fact that hypothermic storage does not significantly impact the structure and characteristics of the chorion membrane compared to unprocessed tissue or its functionality as a scaffold to support tissue growth.


Assessment of Wound Healing Activity and Safety Profile of Amaranthus Spinosus Extract Using Incision Wound Healing Model - Sciencedirect.com
Article by Shravan Kumar Paswan, Pritt Verma, Lucy Mohapatra, Chandana Venkateswara Rao, Sajal Srivastava and Sachin Kumar (India - Current Research in Biotechnology). It can be concluded based on findings that A. spinosus may be used as an alternative medicine in the healing of wound.


Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization - Biomedcentral.com
Article by Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp et al. (Innsbruck, Austria - Inflammation and Regeneration). The authors' findings shed light on cellular interactions in chronic wounds and provide important information for the potential therapeutic use of adipose-derived stem cells in human wound healing.