Hungarian Wound Care Society

Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders - Mdpi.com
Article by Elisabeth Hofmann, Julia Fink, Anna-Lisa Pignet, Anna Schwarz, Marlies Schellnegger, Sebastian P. Nischwitz, Judith C. J. Holzer-Geissler, Lars-Peter Kamolz and Petra Kotzbeck (Graz, Austria - Biomedicines). In this review, the authors summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.

The Potential of Topical Therapy for Diabetic Wounds: A Narrative Review - Cureus.com
Article by Umme Salma Rangwala, Fatema Tashrifwala, Nikita N. Egbert and Abuzar A. Asif (India, USA). The authors that increased blood sugar impairs most phases of wound healing in several ways. Supplementary therapy with either topical or systemic cytokines is shown to promote wound healing in a diabetic wound.

The association between micronutrient levels and diabetic foot ulcer: A systematic review with meta-analysis - Frontiersin.org
Article by Shilia Jacob Kurian, Tejaswini Baral, Mazhuvancherry K. Unnikrishnan, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Mahadev Rao, Amit Kumar and Sonal Sekhar Miraj (India - Front. Endocrinol.). This review provides evidence that micronutrient levels significantly differ in DFU patients, suggesting an association between micronutrient status and risk of DFU. Therefore, routine monitoring and supplementations are warranted in DFU patients. The authors suggest that personalized nutrition therapy may be considered in the DFU management guidelines.

Extracellular vesicles from Lactobacillus druckerii inhibit hypertrophic scar fibrosis - PubMed
Abstract by Fu Han, Kejia Wang, Kuo Shen, Jing Wang, Shichao Han, Dahai Hu and Gaofeng Wu (Shaanxi, China - J Nanobiotechnology).

Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report - PubMed
Abstract by Jose Maria Pereira de Godoy, Ana Carolina Pereira de Godoy, Maria de Fatima Guerreiro Godoy and Dalisio de Santi Neto (Sao Jose do Rio Preto, Brazil - Dermatopathology (Basel)).

Exercise in adults admitted to hospital with diabetes-related foot ulcers: a pilot study of feasibility and safety - PubMed
Abstract by Emily Aitken, Jonathan Hiew, Emma J Hamilton, Laurens Manning, Jens Carsten Ritter, Edward Raby and Paul M Gittings (Australia - J Foot Ankle Res.).

Ischemia Impaired Wound Healing Model in the Rat – Demonstrating Its Ability to Test Proangiogenic Factors - Mdpi.com
Article by Anna T. Hofmann, Paul Slezak, Sabine Neumann,James Ferguson, Heinz Redl and Rainer Mittermayr (Vienna, Austria - Biomedicines). Chronic wounds remain a serious clinical problem with insufficient therapeutic approaches. In this study the authors investigated the dose dependency of rhVEGF165 in fibrin sealant in both ischemic and non-ischemic excision wounds using their recently developed impaired-wound healing model.

Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition - Biomedcentral.com
Article by Pengxiang Zhao, Zheng Dang, Mengyu Liu, Dazhi Guo, Ruiliu Luo, Mingzi Zhang, Fei Xie, Xujuan Zhang, Youbin Wang, Shuyi Pan and Xuemei Ma (Beijing, China - Inflammation and Regeneration). The authors have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. This is the first time to reveal the direct link between H2 and ECM deposition and EpSCs activation.

Natural polymers used in the dressing materials for wound healing: Past, present and futuren - Dovepress.com
Article by Bharti Sheokand, Monika Vats, Anand Kumar, Chander Mohan Srivastava, Indra Bahadur and Seema R. Pathak (India, South Africa - Journal of Polymer Science). This review focuses on the different types of natural polymers such as κ-carrageenan, chitosan, cellulose, gelatin, collagen, alginate, hyaluronic acid, and silk fibroin used in the development of dressing materials such as hydrogels, nanofibers, sponges, films, and various other types of scaffolds owing to their features, for example, biocompatibility, biodegradability, and similarity to human extracellular matrix (ECM) which aids in the healing process.

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing - Dovepress.com
Article by Mengqian Liu, Xuerong Wei, Zijun Zheng, Yicheng Li, Mengyao Li, Jiabao Lin and Lei Yang (Guangzhou, China - International Journal of Nanomedicine). This review describes various recent advances of nano-drug delivery systems involved in mitigating diabetes mellitus-based non-healing wounds.

Burn Wound Management and Treatment - Woundsource.com
Severe burn wounds are among the most debilitating injuries because they can significantly affect the entire body. The body’s inflammatory response to a severe burn injury can lead to fluid loss, dangerously low blood pressure, and shock. The risk of infection is also elevated in patients with severe burn wounds. Therefore, prevention of these complications is a key component of care for these patients.

Malodour from oral malignant fungating wound: sprayed metronidazole - case report - PubMed
Abstract by Haruka Harano, Ryo Matsunuma, Yukako Tanaka-Yagi, Madoka Ito, Junichi Tasaki, Aki Egawa and Takashi Yamaguchi (Kobe, Japan - BMJ Support Palliat Care).

The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis - Biomedcentral.com
Article by Chengzi Huang, Yilian Zhong, Chaochi Yue, Bin He, Yaling Li and Jun Li (Luzhou, China - World Journal of Emergency Surgery). The current evidence suggests that the use of HBO in the treatment of NSTI can significantly reduce the mortality rates and the incidence rates of complications. However, due to the retrospective nature of the studies, the evidence is weak, and further research is needed to establish its efficacy.

Jellyfishes – Significant Marine Resources with Potential in the Wound-Healing Process: A Review - Mdpi.com
Article by Emin Cadar, Ana-Maria Pesterau, Rodica Sirbu, Bogdan Stefan Negreanu-Pirjol and Cezar Laurentiu Tomescu (Romania - Marine Drugs). The advantages of jellyfish collagens over mammalian collagens are highlighted by the fact that jellyfish collagens are not considered transmitters of diseases (spongiform encephalopathy) or various allergic reactions. Jellyfish collagen extracts stimulate an immune response in vivo without inducing allergic complications.

Electronic wound dressing releases drugs to help injuries heal - Newscientist.com
Article by Chris Stokel-Walker. A stretchable sticking plaster detects whether an injury is healing well and uses stimulating electrodes and microinjections of drugs to speed up the process.

Characteristics of Patients with Pressure Injuries in a COVID-19 Referral Hospital - Lww.com
Article by Indri Lakhsmi Putri, Aldrich Alexander Afeli Tungga, Rachmaniar Pramanasari and Citrawati Dyah Kencono Wungu (Indonesia - Adv Skin Wound Care). This retrospective study aimed to describe the characteristics of patients treated at a COVID-19 referral hospital from March 2020 to June 2021 who experienced pressure injuries (PIs) either before or after admission.

Researchers discover how a single mechanosensitive protein induces fibrosis - News-medical.net
Article by Emily Henderson. Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

Diabetic Foot Ulcers: Do You Know Best Practices? - Woundsource.com
Article by Cathy L. Harmon. It is estimated that 25% of adults with diabetes may suffer a DFU sometime in their lifetime, with 20% of those requiring amputation. Since several factors (neuropathy, PAD, foot deformities, etc) can contribute to DFU development, clinicians should use classification systems to assess the best plan of care.

Nurses as Innovators: The Power of Asking Why - Woundsource.com
Article by Mary R. Brennan. Inquisitive nurses have questioned the status quo and challenged the current standards available at the time. The author shares a few stories of nurses who have changed our practice and hopefully inspire you to ask the question: Why are we doing this?

Suprathel® or Mepilex® Ag for treatment of partial thickness burns in children: A case control study - PubMed
Abstract by Matilda Karlsson, Ingrid Steinvall and Moustafa Elmasry (Linköping, Sweden - Burns).

Nanofibrous Scaffolds for Diabetic Wound Healing - Mdpi.com
Article by Anna Yusuf Aliyu and Oluwatoyin A. Adeleke (Halifax, Canada - Pharmaceutics). The authors present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

Fish Skin Grafts Versus Alternative Wound Dressings in Wound Care: A Systematic Review of the Literature - Cureus.com
Article by Mohamed Ibrahim, Haneen S. Ayyoubi, Layth A. Alkhairi, Hozaifa Tabbaa, Isaac Elkins and Ravish Narvel (USA). Although there is no one specific gold standard technique for wound healing, fish skin grafts demonstrated overall improved and quicker wound healing, fewer dressing changes, less pain, and lower costs.

The paradox of obesity in pressure ulcers of critically ill patients - PubMed
Abstract by Fujin Chen, Xiaobo Wang, Yujie Pan, Bukao Ni and Jianhua Wu (Zhejiang, China - Int Wound J.).

Application of extracorporeal shockwave therapy to improve microcirculation in diabetic foot ulcers: A prospective study - Lww.com
Article by Daun Jeong, Jin Hyuck Lee, Gyu Bin Lee, Ki Hun Shin, Jangsun Hwang, Se Youn Jang, Jin Yoo and Woo Young Jang (Seoul, Korea - Medicine). The authors' findings imply that the ESWT may improve microcirculation in patients with Wagner grades I to II DFU. However, this impact requires at least 2 weeks or more than 6 sessions.

Epidemiology of chemical burns: An 11-year retrospective study of 126 patients at a referral burn centre in the north of Iran - PubMed
Abstract by Hojat Eftekhari, Mahsa Sadeghi, Mohammadreza Mobayen, Mojdeh Esmailzadeh, Alireza Feizkhah, Majid Salimi Lahiji, Ali Taghizadeh Pourgarfami and Parissa Bagheri Toolaroud (Iran - Int Wound J.).

Diabetic foot infection - diagnosis and treatment - PubMed
Abstract by Robert Bém (Vnitr Lek.).

Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series - Mdpi.com
Article by Georgios E. Papanikolaou, Georgios Gousios and Niels A. J. Cremers (Greece, The Netherlands - Antibiotics). MGH-based products are clinically and cost-effective for treating hard-to-heal pressure ulcers such as HPUs. Thus, MGH can be recommended as an alternative or complementary therapy in wound healing.

Antibiotic-laden bone cement for diabetic foot infected wounds: A systematic review and meta-analysis - Frontiersin.org
Article by Tingting Dong, Qi Huang and Zengmei Sun (Chengdu, China - Front. Endocrinol). Antibiotic bone cement has significant advantages over traditional treatment of diabetic foot wound infection and is worthy of clinical promotion and application.

EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies - Springer.com
Abstract by Kanchan Shakhakarmi, Jo-Eun Seo, Shrawani Lamichhane, Chhitij Thapa and Sangkil Lee (Daegu, Korea - Archives of Pharmacal Research).

Acellular fish skin for wound healing - Wiley.com
Article by Ali Esmaeili, Esmaeil Biazar, Maryam Ebrahimi, Saeed Heidari Keshel, Bahareh Kheilnezhad and Farzaneh Saeedi Landi (Iran - International Wound Journal). In this review article, recent studies on various decellularization processes as well as biological, physical, and mechanical properties of fish skin and its applications with therapeutic effects in wound healing were investigated.

Bioactive Lavandula angustifolia essential oil-loaded nanoemulsion dressing for burn wound healing. In vitro and in vivo studies - PubMed
Abstract by Małgorzata Miastkowska, Elżbieta Sikora, Agnieszka Kulawik-Pióro, Tomasz Kantyka et al. (Poland, UK - Biomater Adv.).

Patient perceptions and understanding of pressure ulcer risk in the community: Empirical Research Qualitative - PubMed
Abstract by Lisa Jayne Ledger, Peter R Worsley, Jo Hope and Lisette Schoonhoven (UK, The Netherlands - J Adv Nurs.).

Simulating cuts and burns reveals wound healing and clearing power of fibroblasts - Sciencedaily.com
Researchers create a biomimetic model to study wound healing in burn and laceration wounds. They discovered that fibroblasts clear away damaged tissue before depositing new material. This part of the healing process is slower in burn wounds.

The Effect of Hydroxytyrosol in Type II Epithelial-Mesenchymal Transition in Human Skin Wound Healing - Mdpi.com
Article by Wafa Ali Batarfi, Mohd Heikal Mohd Yunus and Adila A. Hamid (Kuala Lumpur, Malaysia - Molecules). This study showed that hydroxytyrosol has the ability to inhibit epithelial mesenchymal transition, which has potential in the inhibition of fibrosis and persistent inflammation related to skin wound healing.

Prognostic factors for delayed healing of complex wounds in adults: A scoping review - PubMed
Abstract by Raquel Marques, Marcos Lopes, Paulo Ramos, João Neves-Amado and Paulo Alves (Portugal, Brazil - Int Wound J.).

A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore – Interim analysis at 6 month follow up - Woundsource.com
Article by Kai Siang Chan, Zhiwen Joseph Lo, Zifei Wang, Priya Bishnoi, Yi Zhen Ng et al. (Singapore - International Wound Journal). This study aims to evaluate the wound healing and quality of life for patients with venous leg ulcers in a Southeast Asian population.

Wound Healing and Healing Process in Patients with Diabetic Foot Ulcers: A Survival Analysis Study - PubMed
Abstract by M Graça Pereira, Margarida Vilaça, Susana Pedras, André Couto de Carvalho, Kavita Vedhara, M Jesus Dantas and Luis Machado (Portugal, UK - Diabetes Res Clin Pract.).

Successful use of amoxicillin-clavulanate acid in a patient with severe wound infection with wound communication secondary to Actinomyces - PubMed
Abstract by Basmah Khalil, Caitlyn Hollingshead and Richard Simman (Toledo, USA - Wounds).

How to Identify Pressure Injuries in Skin of Color - Woundsource.com
Article by Janet Wolfson. Always turn on and maximize lighting when performing assessments. Always turn the patient, when possible, to assess the heel in good light. Moisten when appropriate and palpate all at-risk areas, especially for skin of color on bony prominences, to achieve an assessment worthy of your patient.

Understanding Complicated Surgical Wounds - Woundsource.com
Surgical wounds originate when a surgeon cuts into tissue with a surgical tool, such as a scalpel. The size and placement of a surgical wound will depend entirely on the procedure performed due to varying incision requirements.

Consistent application of compression: an under-considered variable in the prevention of venous leg ulcers - PubMed
Abstract by Harrison J Shawa, Sara E Dahle and R Rivkah Isseroff (USA - Wound Repair Regen.).

Construction and Validation of an Image Discrimination Algorithm to Discriminate Necrosis from Wounds in Pressure Ulcers - Mdpi.com
Article by Shunsuke Sakakibara, Akira Takekawa, Chikara Takekawa, Satoshi Nagai and Hiroto Terashi (Kobe, Japan - JCM). The algorithm identifies the necrotic tissue and wound depth without requiring a large amount of data, making it suitable for application to future AI diagnosis systems for chronic wounds.

Killing Even Antibiotic-Resistant Bacteria: A New Infection-Fighting Wound Spray - Scitechdaily.com
The World Health Organization (WHO) has listed antibiotic resistance as a top ten global health threat, making it imperative to find new ways to combat resistant bacteria and decrease the reliance on antibiotics. In response to this pressing issue, researchers at the Chalmers University of Technology in Sweden have developed a new spray that has the ability to kill even antibiotic-resistant bacteria. This innovative solution can be used for wound care and directly on medical devices such as implants.

Effect of ultrasound-supported wound debridement in subjects with diabetic foot ulcers: A meta-analysis - Wiley.com
Article by Haiting Chen, Ting Xiao, Ling Zhang, Ning Liu, Xia Liang, Tuodi Li, Jinying Wang, Yaozhong Peng, Yanping Liu and Jiali Xu (Wuhan, China - International Wound Journal). A meta-analysis study to assess the effect of ultrasound-supported wound debridement (USSD) in subjects with diabetic foot ulcer (DFU). The USSD applied to DFUs caused a significantly higher wound healing rate compared with the standard care and the placebo.

Incidence rate and risk factors of surgical wound infection in general surgery patients: A cross-sectional study - Wiley.com
Article by Mohammad Taghi Ashoobi, Mohammad Reza Asgary, Milad Sarafi, Narjes Fathalipour, Amir Pirooz, Zakiyeh Jafaryparvar, Elahe Rafiei, Mohaya Farzin, Pirouz Samidoust and Mohammad Sadegh Esmaeili Delshad (Iran - International Wound Journal). Administration of antibiotics, emergency surgery, surgery duration, and levels of white blood cells and creatinine were identified as surgical wound infection-associated risk factors. Identifying important risk factors could help control or prevent surgical wound infections.

Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model - Wiley.com
Article by Ronghua Yang, Xiaoxiang Wang, Wenlian Zheng, Wentao Chen, Wenjun Gan, Xinchi Qin, Jie Huang, Xiaodong Chen and Sitong Zhou (China - International Wound Journal). The results of this study will provide a reference for the elucidation of the pathogenesis and therapeutic targets of keloids.

Mechano-biological and bio-mechanical pathways in cutaneous wound healing - Plos.org
Article by Marco Pensalfini and Adrian Buganza Tepole (West Lafayette, USA). The authors' model challenges the current understanding of wound biomechanics and mechanobiology, beside offering a versatile tool to explore and eventually control scar fibrosis after injury.

Therapeutic Approach of Whole-Body Vibration Exercise on Wound Healing in Animal Models: A Systematic Review - Mdpi.com
Article by Adrielli Brites-Ferreira, Redha Taiar, André Luiz Bandeira Dionizio Cardoso, Daysa De Souza-Santos, Patricia Prado da Costa-Borges, Luiza Torres-Nunes et al. (Brazil, France - IJERPH). The various biological effects of the response to the WBV exercise indicate the relevance of this intervention in wound healing in animals. Considering the translation approach, it is possible to speculate that the beneficial effects of this non-pharmacological therapy might justify clinical trials for wound healing also in humans, after criterion evaluation.

Experimentally Induced Burns in Rats Treated with Innovative Polymeric Films Type Therapies - Mdpi.com
Article by Oxana-Madalina Grosu, Oana-Maria Dragostin, Ioannis Gardikiotis, Carmen Lidia Chitescu, Elena Lacramioara Lisa, Alexandra-Simona Zamfir, Luminita Confederat, Ionut Dragostin, Maria Dragan, Catalina Daniela Stan and Carmen-Lacramioara Zamfir (Romania - Biomedicines). The in vivo study proved that chitosan-derived oxytetracycline membranes showed also improved healing effects which contributes to supporting the idea of using them for the treatment of wounds caused by burns.

Summary of best evidence for prevention and control of pressure ulcer on support surfaces - Wiley.com
Article by Lijun Huang, Yu Yan, Yimin Huang, Yuan Liao, Wenjie Li, Cuijin Gu, Xiaoting Lu, Yu Li and Chun Li (Guangzhou, China - International Wound Journal). The best evidence summarised included a total of 19 recommendations in three areas: type of support surface selection assessment, use of support surfaces, and team management and quality control.

Model construction of factors influencing intensive care unit nurses' medical device-related pressure injury knowledge, attitude, and practice - Wiley.com
Article by Xiao-Xuan Sun, Rui-Bin Chen, Ping-Ping Fang, Ran Yu, Xu-Xing Wang, Jia-Qiu Liu, Ying Chen and Hua Ling (Nanchang, China - International Wound Journal). Nursing managers can develop a reasonable and effective scheduling system and MDRPI training program based on the study results.

The co-design of an exercise-based, lifestyle intervention for people with venous leg ulcers; a self-care, expert-supported strategy for a chronic condition - Wiley.com
Article by Emma McIntosh, Michelle Horspool, Maria Levesley, Pip Logan and Markos Klonizakis (UK - International Wound Journal). FISCU Home could provide a mainstream adjunct therapy in wound care and support the movement towards self-management.

Larval Therapy as a Wound Healing Acceleration in Chronic Wounds : A Scoping Review - Upm.edu.my
Article by Fatimah Fauzi Basalamah, Hendrik Setia Budi, Nurina Febriyanti Ayuningtyas and Diah Savitri Ernawati (Surabaya, Indonesia - Malaysian Journal of Medicine and Health Sciences). The authors found articles related to the use of larval therapy as many as 15 articles between 2012-2020 that were eligible for review. Chronic wound therapy using larvae is easy to apply and is successful as a traditional and complementary medicine.

The Role of the Plastic Surgeon in Wound Care - Hmpgloballearningnetwork.com
Article by Richard Simman, Fuad-Tahsin Abbas and Darren Gordon (USA - Wounds). Careful attention to fundamentals, including nutritional status, wound debridement, and comorbidities, combined with a strong understanding of the indications mentioned in this article that warrant the involvement of a plastic and reconstructive surgeon, can result in efficient, rapid wound healing at relatively minimal cost.

Obesity and Wound Healing: Focus on Mesenchymal Stem Cells - Mdpi.com
Article by Antonio Alma, Guya Diletta Marconi, Elena Rossi, Cristina Magnoni and Alessia Paganelli (Italy, Life). The aim of this review is to give an overview of the most recent findings on wound healing, with a special focus on adipose tissue biology and obesity.

Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model - Mdpi.com
Article by Roel C. Op ‘t Veld, Lieke Joosten, Peter Laverman, Ewald M. Bronkhorst, John A. Jansen, X. Frank Walboomers and Frank A. D. T. G. Wagener (Nijmegen, The Netherlands - IJMS). Polyisocyanopeptide gels are atraumatic and perform similarly to currently employed wound dressing materials, offering possible future benefits for both clinicians and patients.

Dried human-cultured epidermis accelerates wound healing in a porcine partial-thickness skin defect model - Mdpi.com
Article by Takashi Nakano, Michiharu Sakamoto, Yasuhiro Katayama, Yoshihiro Shimizu, Masukazu Inoie, Yuanjiaozi Li, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito and Naoki Morimoto (Japan, Regenerative Therapy). The authors studied the safety and efficacy of human-dried cultured epidermis in wound healing using a miniature swine model.

Preparation and identification of new antibacterial and biocompatible dressings based on gelatin/polyvinyl alcohol and castor oil - Mdpi.com
Abstract by Ashkan Farazin, Chunwei Zhang and Amir Hossein Ghasemi (China, Iran - Journal of Polymer Research).

Effect of Chitosan-Diosgenin Combination on Wound Healing - Mdpi.com
Article by Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov and Albena Alexandrova (Sofia, Bulgaria - IJMS). The combined application of chitosan and diosgenin is a very promising and effective medication for wound healing.

Uncommon Wounds: Frostbite and Winter Woes - Woundsource.com
Article by Lauren Lazarevski. Many clinicians practicing in warm climates may never see a case of frostbite. Those in temperate or colder climates should be prepared for weather emergency-related injuries, including frostbite /cold injury. These wounds aren't caused by ordinary ischemia; the pathophysiology of frostbite is a perfect example of the importance of understanding wound etiology to ensure proper management of these injuries.

Meta-analysis of randomized controlled studies of closed incisional negative pressure wound therapy versus standard wound dressing in the prevention of surgical site infections for patients undergoing surgeries for lower extremity fractures - PubMed
Abstract by Fu-Yu Lin, Tomas Kempny, Martin Knoz and Hsu-Tang Cheng (Taiwan, Czech Rep. - J Plast Reconstr Aesthet Surg.).

Degassing a Decellularized Scaffold Enhances Wound Healing and Reduces Fibrosis during Tracheal Defect Reconstruction: A Preliminary Animal Study - Mdpi.com
Article by Nguyen-Kieu Viet-Nhi, Yen-Chun Chen, Luong Huu Dang, How Tseng and Shih-Han Hung (Taipei, Taiwan - JFB). The results suggest that the degassing processing might be a simple and effective way to improve the biocompatibility of small intestinal submucosa.

Ozone Therapy Benefits: How It Can Boost Your Immune System - Healthnews.com
Article by Klaudia Balogh. Ozone therapy is used for treating a number of chronic and acute health conditions and viral and bacterial infections, as well as boosting immunity, physical and mental performance, and healing wounds. A study has even seen neurogenic potential and potential use of ozone therapy as a preventative treatment for aging and neurodegenerative diseases. Other studies have found ozone therapy to enhance healing of chronic wounds.

Treatment of Chronic Lower Limb Wounds and Limb-Salvage Surgery in Diabetic Patients - Mdpi.com
Article by Tímea Hevér (Budapest, Hungary - Biomed J Sci & Tech Res). Chronic lower limb wounds with different etiology need complex, individual, persistent treatment to avoid major limb amputation. This paper summarizes the importance of ulcer treatment. Patient at least satisfactory cooperation is also essential to start the treatment in proper time to save extremities.

Fascia Layer – A Novel Target for the Application of Biomaterials in Skin Wound Healing - Mdpi.com
Article by Haifeng Ye and Yuval Rinkevich (Munich, Germany - IJMS). The development of some new biomaterials targeted for application in the right position of the skin to accelerate wound healing and achieve scar-free healing is a problem that the research community is trying to solve today.

Too Much of a Good Thing? - Hmpgloballearningnetwork.com
Article by Terry Treadwell (Wounds). Since hypertrophic granulation tissue cannot be ignored if satisfactory healing is to be achieved, this is truly a situation where too much of something is not necessarily good.

When Palliative Care May Be the Only Option in the Management of Severe Burns: A Case Report Written With the Help of ChatGPT - Cureus.com
Article by Akiva Nachshon, Baruch Batzofin, Michael Beil and Peter V. van Heerden (Jerusalem, Israel). In this reported case surgery was not possible without causing major disfigurement, including enucleation of both eyes and amputation of all limbs.

Preliminary evaluation of haemostatic and wound healing potential of Heliotropium europaeum - Springer.com
Abstract by D. R. Moalla, S. Ben Khedir, Sameh Amouri, Neila Jardak, Tarek Rebai and Zouheir Sahnoun (Sfax, Tunisia - Archives of Dermatological Research).

Clinical study of early rehabilitation training combined with negative pressure wound therapy for the treatment of deep partial-thickness hand burns - Nih.gov
Article by Canbin Liu, Hongteng Xie, Pei Wei, Teng Gong, Guohua Wu, Zhaorong Xu and Shun Chen (China, Australia, Switzerland - Front Surg.). The application of early rehabilitation training combined with NPWT to treat deep partial-thickness hand burns can effectively improve hand function.

Overcoming Barriers to Wound Healing in a Neuropathic and Neuro-Ischaemic Diabetic Foot Cohort Using a Novel Bilayer Biodegradable Synthetic Matrix - Mdpi.com
Article by Frank P. Guerriero, Robyn A. Clark, Michelle Miller and Christopher L. Delaney (Adelaide, Australia - Biomedicines). The authors' study reports on the impact of bilayer biodegradable synthetic matrix technology (NovoSorb® BTM) on the healing and amputation rates of a diabetic foot ulceration cohort.

In vitro and in vivo synergistic wound healing and anti-methicillin-resistant Staphylococcus aureus (MRSA) evaluation of liquorice-decorated silver nanoparticles - Nature.com
Article by Hamdoon A. Mohammed, Mohammed A. Amin, Gamal Zayed, Yassar Hassan, Mohamed El-Mokhtar and Mohammed S. Saddik (Saudi Arabia, Egypt, Iraq - The Journal of Antibiotics). The formulation of silver nanoparticles with liquorice extract showed synergetic effects in enhancing the treatment of wounds, with significant antibacterial activity against E. coli and MRSA.

How Mobile Patient Engagement Could Improve Adherence and Outcomes - Woundsource.com
Even before the onset of COVID-19 and certainly since, health care facilities have faced challenges related to resources, staffing, and infection control. However, telehealth resources can aid across the care continuum.