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News from the field of wound care and wound healing - July, 2023

Mannose-Decorated Co-Polymer Facilitates Controlled Release of Butyrate to Accelerate Chronic Wound Healing - Wiley.com
Article by Abigail L. Lauterbach, Anna J. Slezak, Ruyi Wang, Shijie Cao, Michal M. Raczy, Elyse A. Watkins, Carlos J. Medina Jimenez and Jeffrey A. Hubbell (Chicago, USA). The authors' novel platform is positioned to address a large unmet clinical need and improve the closure of otherwise non-healing wounds.


Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets - Springer.com
Article by Jacob G. Hodge, Jennifer L. Robinson and Adam J. Mellott (USA - Tissue Engineering and Regenerative Medicine). This study demonstrates how critical the culture environment is on influencing ASC-secretome regenerative capabilities. Additionally, the critical role of EVs in modulating epidermal regeneration is revealed and their translatability for future clinical therapies is discussed.


Factors Affecting Severity of Pressure Ulcers: Impact of Number of Medications - PubMed
Abstract by Kenichi Arai, Kohei Yamamoto, Takaaki Suzuki, Yuki Shiko, Yohei Kawasaki, Nobuyuki Mitsukawa and Ituko Ishii (Chiba, Japan - Wound Repair Regen.).


Skin models of cutaneous toxicity, transdermal transport and wound repair - Oup.com
Article by Inês Vilela de Sousa, Miguel J S Ferreira, Luís B Bebiano, Sandra Simões, Ana Filipa Matos, Rúben F Pereira and Pedro L Granja (Portugal - Burns & Trauma). In this review, skin models for transdermal transport, wound repair and cutaneous toxicity will be discussed with a focus on high-throughput strategies.


Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing - Hindawi.com
Article by Limin Bai, Xiaowei Zhang, Xiaomei Li, Susu Wang, Yeshun Zhang and Gang Xu (China - Journal of Diabetes Research). The authors' results demonstrate that the sericin/i-PRF hydrogel is a promising agent for diabetic wound healing.


Clinical Pathways for Management of Venous Leg Ulcers - Woundsource.com
Venous ulcers pose a worldwide problem that comes with potential for high recurrence rates, risk of infection, and substantial treatment costs. Health care professionals must be knowledgeable about underlying causes and pathological features.


Venous Leg Ulcers and Infection - Woundsource.com
Venous leg ulcers (VLUs) are the most common type of chronic leg wound, and can be challenging to manage. VLUs account for up to 90% of all chronic leg ulcers. Proper diagnosis and treatment planning are key to wound healing outcomes. This fact is particularly true for older adults, who have an annual VLU prevalence of 1.7%.


Vacuum sealing drainage to treat Fournier's gangrene - PubMed
Abstract by Ju-Hua Chen, Yu-Bo Li, De-Gang Li, Xiao-Mei Zeng, Qiu-Yuan Yao, Jun Fu, Gong-He Wang and Xiao-Yan Huang (China - BMC Surg.).


Hyaluronic acid for chronic wound healing - Cochrane.org
The aim of this review was to evaluate the effects of hyaluronic acid on the healing of chronic wounds. Hyaluronic acid is a naturally occurring molecule present in human cells. Chronic wounds are wounds that take a long time to heal. They include pressure ulcers, foot ulcers, and leg ulcers.


Protein in Cows’ Milk Improves Wound Healing - Technologynetworks.com
Researchers at UCL found that casein, a protein in milk, when combined with a biodegradable polyester, could create antimicrobial bandages with faster wound healing. In animal tests, casein-infused bandages reduced wound size significantly (5.2%) after 14 days, suggesting potential as a cost-effective alternative to expensive wound dressings.


An Overview of Clinical Examinations in the Evaluation and Assessment of Arterial and Venous Insufficiency Wounds - Mdpi.com
Article by Szu-Han Wang, Victor Bong-Hang Shyu, Wen-Kuan Chiu, Ren-Wen Huang, Bo-Ru Lai and Chia-Hsuan Tsai (Taiwan - Diagnostics). In this review, the authors provide a comprehensive overlook of the most widely used and available clinical examinations for arterial and venous insufficiency wounds.


Sublesional fat grafting leads to a temporary improvement of wound healing in chronic leg ulcers: A prospective, randomized clinical trial - Wiley.com
Abstract by Oliver C. Thamm, Johannes Eschborn, Lucas Zimmermann, Clara Dekker, Hubert Marti, Michael Brockmann, Max J. Zinser and Paul C. Fuchs (Germany, Switzerland - International Wound Journal).


In vitro wound healing effects of combinations of Aloe vera gel with different extracts of Bulbine frutescens - Sciencedirect.com
Article by Anri Hattingh, Jean-Pierre Laux, Clarissa Willers, Josias Hamman, Dewald Steyn and Hannlie Hamman (South Africa - South African Journal of Botany). The wound healing properties of A. vera gel can be increased by combining it with B. frutescens aqueous extract.


Full-Thickness Skin Columns: A Method to Reduce Healing Time and Donor Site Morbidity in Deep Partial-Thickness Burns - PubMed
Abstract by Corey S Keenan, Laura Cooper, Kristo J Nuutila, Javier Chapa, Sean Christy, Rodney K Chan and Anders H Carlsson (USA - Wound Repair Regen.).


COVID-19 and primary wound healing: A new insights and advance - Wiley.com
Article by Danyi Li, Wenjie Cao, Qun Zhou, Xiaomin Wu, Xiayun Song and Haofang Qin (Shanghai, China - International Wound Journal). Strict control measures of blocking up COVID-19 pandemic can also have side effects on primary wound healing process.


Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing - Oup.com
Article by Mengting Zhu, Lijuan Cao, Sonia Melino, Eleonora Candi, Ying Wang, Changshun Shao, Gerry Melino, Yufang Shi and Xiaodong Chen (Italy, China - Stem Cells Translational Medicine). The authors outline current insights into the ways in which MSCs sense and modulate inflammation undergoing the process of wound healing, highlighting the central role of neutrophils, macrophages, and T cells during the interaction. They also draw attention to the specific effects of MSC-based therapy on different pathological wound healing.


Regeneration might be a whole-body affair - Eurekalert.org
In certain organisms, injuries on one part of the body can induce a healing response in another. New evidence suggests this whole-body response isn’t a side effect: it’s the main feature.


Editorial: New Strategies for the Diagnosis and Treatment of Multi-Drug Resistant Bacteria or Fungi in Wounds - Frontiersin.org
Article by Kok-Yong Chin (Malaysia - Front. Mol. Biosci.). A multidisciplinary approach is required to tackle the issue of infection in delayed wound healing. Continuous innovations in the field of diagnostics, surveillance, and therapeutics are warranted, given the ever-changing landscape of multiresistant microorganisms.


The Effect of a Zinc-L-Carnosine Mouthwash in the Management of Oral Surgical Wounds: Preliminary Results of a Prospective Cohort Study - Mdpi.com
Article by Fabio Dell’Olio, Rosaria Arianna Siciliani, Gianluigi Novielli, Angela Tempesta, Gianfranco Favia and Luisa Limongelli (Bari, Italy - Dentistry Journal). The preliminary results of this study showed that the zinc–L-carnosine mouthwash improved the quality of oral surgical wound healing.


Keloid Development After Fine Needle Aspiration of the Thyroid: A Rare Case and Review of Management Strategies - Cureus.com
Article by Shaniah S. Holder, Alaerebo S. Malvan-iyalla, Sara Arfan, Vimal Basani and Frederick Tiesenga (Barbados, USA - Cureus). This report aims to explore this unique occurrence, highlight the interplay between epidemiology, race, and genetics in influencing the development of keloids, and review the management strategies for neck keloids.


Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis - Wiley.com
Article by Daniela Balderas-Cordero, Octavio Canales-Alvarez, Roberto Sánchez-Sánchez, Alejandro Cabrera-Wrooman, Maria Margarita Canales-Martinez and Marco Aurelio Rodriguez-Monroy (Mexico - IJMS). The authors' findings suggest that the topical administration of ChEEP can improve skin wound healing, probably due to the synergistic effect of its components, mainly polyphenols, in different steps of the wound-healing process. It should be noted this is the first time that the wound-healing activity of a Mexican propolis has been evaluated.


Ancient Egyptians' Ingenious Use of Moldy Bread and Honey as an Antibiotic to Treat Wounds - Newstracklive.com
Article by Sanskar Tiwari. In the annals of ancient civilizations, the Ancient Egyptians stand out for their profound contributions to science, medicine, and culture. Among their many innovations, they pioneered the use of moldy bread and honey as a remarkable antibiotic to treat wounds. Such unconventional remedies highlight the ingenuity and forward-thinking of this ancient civilization, whose knowledge continues to surprise and intrigue modern researchers.


Autologous Cell Therapy Effective in Wound Treatment - Dermatologytimes.com
Researchers applied EB-101, a new cell therapy, to patients with recessive dystrophic epidermolysis bullosa with positive results.


Impact of autologous platelet concentrates on wound area reduction: A meta-analysis of randomized controlled trials - Wiley.com
Article by Bangli Tang, Zhongkui Huang and Xuhai Zheng (Mianyang, China - International Wound Journal). The authors' findings suggest that APCs can effectively reduce wound areas when compared to conventional treatments, without increasing the risk of infection. In addition, the effectiveness of APCs in wound area reduction may vary depending on factors such as wound location, type of APCs used, and follow-up duration.


Blue light therapy. An alternative approach for treatment of vascular skin ulcers - PubMed
Abstract by Alessandro Morgante and Andrea Li Destri (Ann Ital Chir.).


Does the Use of Negative Pressure Wound Therapy and Postoperative Drains Impact the Development of Surgical Site Infections?: A PARITY Trial Secondary Analysis - PubMed
Abstract by Christa L LiBrizzi, Samir Sabharwal, Jonathan A Forsberg, Lee Leddy, Yee-Cheen Doung, Carol D Morris, Adam S Levin and PARITY Investigators (USA - J Bone Joint Surg Am.).


Impact of moist wound dressing on wound healing time: A meta-analysis - Wiley.com
Article by Zhengbo Liang, Ping Lai, Jing Zhang, Qing Lai and Lin He (Deyang, China - International Wound Journal). This study underscores the significant advantages associated with the use of moist dressings, including expedited wound healing, reduced infection rates, decreased frequency of dressing changes, and lower overall treatment costs.


Robust classification of wound healing stages in both mice and humans for acute and burn wounds based on transcriptomic data - Escholarship.org
Article by Ksenia Zlobina, Eric Malekos, Han Chen and Marcella Gomez (Santa Cruz, USA - eScholarship). This work suggests that there are universal characteristics of gene expression in wound healing stages despite the seeming disparities across species and wounds.


A Sustained-Release Nanosystem with MRSA Biofilm-Dispersing and -Eradicating Abilities Accelerates Diabetic Ulcer Healing - Dovepress.com
Article by Shan He, Huangding Wen, Nannan Yao, Lu Wang, Junqun Huang and Zhiqing Li (China - International Journal of Nanomedicine). Electrospun Tea tree oil nanoliposomes / polyvinyl alcohol/chitosan demonstrates the remarkable potential for accelerating diabetic and MRSA-infected wound healing.


Common Peristomal Skin Complications: How to Prevent and Manage - Woundsource.com
Article by Elizabeth Day Dechant. Peristomal skin complications include inflammation, injury, or damage to the skin surrounding an abdominal stoma. These complications are common, with as high as 80% reported incidence.


Wound Dressings: What’s New? - Woundsource.com
In this interview, Cathy Milne and Jayesh Shah discuss new wound dressings and other wound care products they see on the horizon.


Wound healing strategies based on nanoparticles incorporated in hydrogel wound patches - Rsc.org
Article by Paulami Dam, Merve Celik, Merve Ustun, Sayantan Sahaa, Chirantan Sahaa, Elif Ayse Kacardl, Senanur Kugudl, Elif Naz Karagulleb et al. (India, Turkey, Brazil - RSC Adv.). Better wound care/healing techniques are now possible, thanks to the development of wound healing strategies based on these materials, which mimic the extracellular matrix (ECM) microenvironment of the wound.


A Comparison Between the Effectiveness of Isoamyl 2-Cyanoacrylate Tissue Adhesive and Silk Sutures in Wound Closure Following Minor Oral Surgical Procedures: A Prospective Clinical Study - Cureus.com
Article by Javed Akhter, Sangita Kalita, Rohit Goyal, Pooja Jaiswal, Karthikeyan Ramalingam and Divya Yadav (India - Cureus). Authors observed that IAC was as effective as the gold standard silk suture. The advantages of IAC are its hemostatic and bacteriostatic qualities, and IAC also took less time to complete the procedure.


From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds - Biomedcentral.com
Article by Gabriela Olimpia Isopencu, Cristina-Ileana Covaliu-Mierlă and Iuliana-Mihaela Deleanu (Bucharest, Romania - Plants). Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems.


Hydrogel Dressings - News-medical.net
Article by Liji Thomas. Hydrogel dressings are an emerging area for wound care, as they increase the speed and success of wound healing.


Wound healing effects of Asparagus lucidus Lindl extract through the phosphorylation of ERK1/2 - Biomedcentral.com
Article by Minho Kim and Ki-Young Kim (Yongin-si, Korea - BMC Complementary Medicine and Therapies). Asparagus lucidus Lindl extract promotes keratinocyte proliferation by activating the extracellular signal-regulated kinase 1/2 pathway and up-regulating the mRNA expression of c-fos, c-jun, and vascular endothelial growth factor.


Negative pressure wound therapy: Where are we in 2022? - Biomedcentral.com
Abstract by Michael A Quacinella, Taylor M Yong, William T Obremskey and Daniel J Stinner (Nashville, USA - OTA Int.).


End-stage kidney disease: a never healing wound leading to another never healing wound, renal cancer - Springer.com
Article by Janos Docs, Gyula Kovacs and Lehel Peterfi (Hungary, Germany - Journal of Nephrology). The progressive inflammatory and fibrotic processes in end-stage kidney disease have features recalling those of a never healing wound and may explain the frequent development of kidney cancer.


Full-thickness dermal wound regeneration using hypoxia preconditioned blood-derived growth factors: A case series - Tandfonline.com
Article by Hadjipanayi Ektoras, Moog Philipp, Jiang Jun,Dornseifer Ulf, Machens Hans-Günther and Schilling Arndt F (Germany - Organogenesis). The method is readily clinically applicable, cost effective, and overcomes limitations of the classic reconstructive approach.


Ancient remedy oxymel shows potential for modern wound care - New-medical.net
Article by Lily Ramsey. The mixture of honey and vinegar, also known as oxymel, has been used as a medical treatment throughout history and now scientists have established that this combination could have modern applications in the treatment of wounds. New research, published in Microbiology, is the first comprehensive exploration of how the mixture could be applied to modern medicine and improve treatments for infections.


Effectiveness of incisional negative pressure wound therapy after major lower extremity amputation: a randomised controlled trial - PubMed
Abstract by V. V. Vaddavalli, B. Girdhani, A. Savlania, A. Behera, A. Rastogi, L. Kaman and K. Abuji (Chandigarh, India - Ann R Coll Surg Engl.).


A systematic review of nursing students' attitude and related factors towards pressure ulcer prevention - PubMed
Abstract by Alaa Hamza Hermis, Amirabbas Mollaei, Pooyan Ghorbani Vajargah and Samad Karkhah (Iraq, Iran - Int Wound J.).


Placental-Derived Biomaterials and Their Application to Wound Healing: A Review - Mdpi.com
Article by Nicole M. Protzman, Yong Mao, Desiree Long, Raja Sivalenka, Anna Gosiewska, Robert J. Hariri and Stephen A. Brigido (USA - Bioengineering). This review provides an overview of wound healing and placental-derived biomaterials, summarizes the clinical results of placental-derived scaffolds in wound healing, and suggests directions for future work.


Hyaluronic acid accelerates re-epithelialization and healing of acute cutaneous wounds - Europeanreview.org
Article by F. de Francesco, A. Saparov and M. Riccio (Italy, Kazakhstan - European Review for Medical and Pharmacological Sciences). The treatment with hyaluronic acid 0.2% yielded remarkable outcomes in the re-epithelialization of superficial wounds and provided favorable recovery and tolerance for patients.


Effect of hydrocolloid dressings in the management of different grades of pressure wound ulcers in critically ill adult subjects: A meta-analysis - Wiley.com
Article by Ruifeng Huang, Zhaozhao Hua, Lan Li, Yiyuan Zhou, Yuefang Xu and Taiwei Zhang (Guiyang, China - International Wound Journal). HCDs had significantly higher PWU complete healing, PWU stage II ulcers complete healing, and PWU stage III ulcers complete healing compared to control in critically ill adult persons. However, when interacting with its values, caution must be taken since a low sample size of most of the chosen researchers was found for the comparisons in the meta-analysis (5 out of 8 < 100 persons).


Progress of Research on Antioxidants and Carriers for Skin Wound Repair - Mdpi.com
Article by Xiaoxuan Zhu, Wenlu Yuan, Zhuozheng Li, Yin Lin, Wenfang Li, Dan Wang, Huafang Zhang and Yingshuai Wang (Weifang, China - Processes). This paper presents a review of the progress of research on (1) antioxidants and (2) antioxidant carriers for skin repair in order to summarize the research results and provide reference for the subsequent development of new drug-carrier structures and new skin repair strategies.


Autologous Blood Clots: A Natural Biomaterial for Wound Healing - Frontiersin.org
Abstract by David M. Richter, Jennifer C. Ku, Kayla E. Keckler, Lacey R. Burke, Genevieve M. Abd and Yong Li (USA - Front. Mater. Sec. Biomaterials and Bio-Inspired Materials).


Efficacy of incisional negative pressure therapy in preventing post-sternotomy wound complications - Americanjournalofsurgery.com
Abstract by L. B. Traylor, G. Bhatia, D. Blackhurst, G. Wallenborn, A. Ewing, W. Bolton and B. Davis (Greenville, USA - AJS).


Tips and Tricks for Managing Negative Pressure Wound Therapy (NPWT) - Woundsource.com
Article by Holly M. Hovan. NPWT can require a creative approach when applying it to achieve a seal, especially depending on the location of the wound. It is used when more common treatment options have been exhausted or with larger, more complex wounds.


NPWT: Key Strategies for Success - Woundsource.com
How do providers apply negative pressure wound therapy (NPWT) to the wound bed? In this interview, Emily Greenstein shares several tips for NPWT application and use that she finds helpful in her practice.


The impact of healthcare assistant education on pressure ulcer prevention: a systematic review - PubMed
Abstract by Noreen O'Brien, Zena Moore, Pinar Avsar, Declan Patton, Linda Nugent and Tom O'Connor (Ireland, Saudi Arabia, Belgium, China, Australia - J Wound Care).


CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus - Biomedcentral.com
Article by Ching Chen, Liang-Yu Lin, Jaw-Wen Chen and Ting-Ting Chang (Taipei, Taiwan - Cardiovascular Diabetology). CXCL5 suppression could improve neovascularization and wound healing through CXCR2 in DM. CXCL5 may be regarded as a potential therapeutic target for vascular complications of DM.


Films for Wound Healing Fabricated Using a Solvent Casting Technique - Mdpi.com
Article by Fabiola V. Borbolla-Jiménez, Sheila I. Peña-Corona, Sonia J. Farah, María Teresa Jiménez-Valdés, Emiliano Pineda-Pérez, Alejandra Romero-Montero et al. (Mexico - Pharmaceutics). This review focuses on the polymeric dressings obtained using this technique, emphasizing the critical manufacturing factors related to pharmaceuticals, specifically discussing the formulation variables necessary to create wound dressings that demonstrate effective performance.


Pressure injuries in the operating room: who are at risk? - PubMed
Abstract by Ezgi Dilan Özdemir, Yasemin Uslu, Ukke Karabacak, Dilek Eren and Serpil Isabetli (Istanbul, Turkey - J Wound Care).


The influence of negative pressure wound therapy on bacterial and fungal growth - PubMed
Abstract by Niklas Biermann, Christian D Taeger, Valentin Schatz, Andreas Eigenberger, Lukas Prantl and Oliver Felthaus (Regensburg, Germany - J Tissue Viability).


Healing of a Chronic Wound after Extensive Burn Injury in An Elderly Patient Using Marine Omega3 Wound Matrix and Split-Thickness Skin Micro-Grafts: A Case Report - Fortunejournals.com
Article by Christian Smolle, Judith C. Geißler, Sebastian Nischwitz, Hannah Luze and Lars-Peter Kamolz (Graz, Austria - Archives of Clinical and Medical Case Reports). Authors present a case of an elderly burn patient with chronic wounds that were ultimately healed using marine omega3 wound matrix for wound conditioning and meek micrografting for closure. As the patient general health status did not allow surgery under general anaesthesia, skin grafting was performed bed-side under topical anaesthesia.


Use of Multimodal Long-Wave Infrared Thermography Devices in Clinical Practice - Hmpgloballearningnetwork.com
Article by Richard Simman, Darren M Gordon, Kara Klomparens and Frank Aviles Jr. (USA). Through this case series, authors show the many advantages of LWIT devices. This technology is safe, noninvasive, and user friendly and, most importantly, gives objective, instant, and repeatable measurements.


Eschar Dermabrasion in Deep Dermal Partial-Thickness Burn: A Case Report - Lww.com
Article by Mengru Pang, Liang Zhao, Siye Liu and Yu Lei (Guiyang, China - Advances in Skin & Wound Care). With eschar dermabrasion, necrotic tissue can be removed to the greatest extent with minimal damage. Early use can help patients skip the scab-dissolving period, decrease local and systemic inflammation, reduce postoperative scarring, and significantly reduce the difficulty of early wound care.


Determining the measurement accuracy in assessing the progress of wound healing - Termedia.pl
Article by Paweł T. Dolibog, Patrycja Dolibog and Daria Chmielewska (Poland - Advances in Dermatology and Allergology). The analysis of the wound images obtained in the ACS showed a very high potential of the software in terms of the accuracy of the analysed areas, which significantly increases the possibility of the analysis and reduces the measurement error in relation to planimetry using a digital digitizer.


Wounds resulting from non-malignant haematological disease: a case series - PubMed
Abstract by Richard Simman, Drew Oostra, Patrick Sullivan, Michael Wilson, Jude Khatib and Sarah E Jackson (USA - J Wound Care).


Development of a Wound-Healing Protocol for In Vitro Evaluation of Urothelial Cell Growth - Mdpi.com
Article by Christopher Foster, Todd Jensen, Christine Finck and Courtney K. Rowe (USA - MPs). This study shows the development of a clinically relevant wound-healing assay to evaluate urothelial cell growth. It is the first to compare GFs for future use in reconstructive techniques to improve urethral healing.


A multicenter, randomized controlled clinical trial evaluating the effects of a novel autologous heterogeneous skin construct in the treatment of Wagner one diabetic foot ulcers: Final analysis - Wiley.com
Article by David G. Armstrong, Dennis P. Orgill, Robert Galiano, Paul M. Glat, Lawrence Didomenico, Nikolai A. Sopko, Edward W. Swanson, Felix Sigal, Robert Snyder, William W. Li, Marissa Carter and Charles M. Zelen (USA - International Wound Journal). Autologous heterogeneous skin construct was shown to be an effective adjunctive therapy for healing Wagner 1 diabetic foot ulcers.


Antioxidant and Wound Healing Bioactive Potential of Extracts Obtained from Bark and Needles of Softwood Species - Mdpi.com
Article by Elisabeta-Irina Geana, Corina Teodora Ciucure, Radu Tamaian, Ioana Cristina Marinas, Diana Mădălina Gaboreanu, Miruna Stan and Carmen Lidia Chitescu (Romania - Antioxidants). Numerous phenolic acids, flavonoids, stilbenes, terpenes, lignans, secoiridoids, and indanes with antioxidant, antimicrobial, anti-inflammatory, antihemolytic, and anti-carcinogenic potential were identified. The Abies alba needle extract was more toxic to microbial strains than the eukaryotic cells that provide its active wound healing principles.


Biopsy: Is it a DFU or Carcinoma? (And Why Does it Matter?) - Woundsource.com
Article by Laura Swoboda. When assessing patients and their wounds, findings that would raise suspicion for the need for wound biopsy, in author's experience, include Dimensions not improving as expected, among other factors.


Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects - Mdpi.com
Article by Mariana Chelu, Adina Magdalena Musuc, Monica Popa and Jose Calderon Moreno (Bucharest, Romania - Gels). This review provides valuable information on the current status of Aloe vera-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.


Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation - Dovepress.com
Article by Wen Zhao, Huimin Zhang, Rui Liu and Rongtao Cui (Jinan, China - International Journal of Nanomedicine). This review gave a comprehensive summary of MSC-Exo immunomodulating different immune cells in wound healing and scar formation to provide basic theoretical references and therapeutic exploration of inflammatory wound healing and pathological scars.


Innovations in Wound Dressings: pipeline summary - Medicaldevice-network.com.com
According to GlobalData’s medical device pipeline database, 444 Wound Dressings devices are in various stages of development globally. GlobalData’s report Wound Dressings provides an overview of the segment’s pipeline landscape and offers detailed analysis of its products.


Chitosan–Collagen Electrospun Nanofibers Loaded with Curcumin as Wound-Healing Patches - Mdpi.com
Article by Maila Castellano, Andrea Dodero, Sonia Scarfi, Serena Mirata, Marina Pozzolini, Eleonora Tassara, Alina Sionkowska, Katarzyna Adamiak, Marina Alloisio and Silvia Vicini (Italy, Switzerland, Poland - Polymers). Combining chitosan and collagen not only ensures prolonged stability and optimal physical–chemical properties but also allows for better-promoting cell adhesion and proliferation and enhanced anti-bacteriostatic capabilities with the addition of curcumin, owing to its beneficial anti-inflammatory effect, ameliorating the attachment and survival/proliferation rates of keratinocytes and fibroblasts to the fabricated patches.


Wound Healing and Photobiomodulation Therapy in Diabetic Patients - Walshmedicalmedia.com
Article by Melanie Lenita (Dalian, China - Diabetes Case Reports). PBM therapy is a promising technique that can improve wound healing in diabetic patients by modulating various cellular and molecular processes. PBM therapy can also improve the physical performance and quality of life of diabetic patients.


Green Synthesis of Silver Nanoparticles Loaded Hydrogel for Wound Healing; Systematic Review - Mdpi.com
Article by Fahad M. Aldakheel, Marwa M. El Sayed, Dalia Mohsen, Mohammed H. Fagir and Dalia K. El Dein (Saudi Arabia, Egypt - Gels). This review highlights the potential of green-synthesized AgNPs loaded in Polyacrylamide hydrogel as promising for advanced wound healing therapies.


A volar skin excisional wound model for in situ evaluation of multiple-appendage regeneration and innervation - Oup.com
Article by Huanhuan Gao, Yiqiong Liu, Ziwei Shi, Hongliang Zhang, Mengyang Wang, Huating Chen et al. (Beijing, China - Burns & Trauma). VEWM closely reflects the pathological features of human wound healing and can be applied for skin multiple-appendages regeneration and innervation evaluation.


The immune function of dermal fibroblasts in skin defence against pathogens - PubMed
Abstract by Jianing Wang, Zhimin Duan, Xu Chen and Min Li (China - Exp Dermatol.).