Hungarian Wound Care Society

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News from the field of wound care and wound healing - January, 2023

Gamma irradiation mediated production improvement of some myco-fabricated nanoparticles and exploring their wound healing, anti-inflammatory and acetylcholinesterase inhibitory potentials - Nature.com
Article by El-Sayed R. El-Sayed, Doaa S. Mansour, Reham M. Morsi and Hanan A. Abd Elmonem (Cairo, Egypt - Scientific Reports). The obtained results confirmed the promising wound healing, anti-inflammatory, and acetylcholinesterase inhibition potentials of the three types of nanopraticles.


What is the Impact of Social Determinants of Health on Wound Management - Woundsource.com
Article by Holly Hovan. Research has shown that social stressors impede wound healing, and the patient’s environment is responsible for up to a 50% variation in healing. This variation may be positive or negative, depending on the environment.


Comprehensive Amputee Care: Not Such a New Concept - Woundsource.com
Article by Christine Miller. A limb salvage program aims to prevent major amputations, improving patients' quality of life. Despite the efforts of a multidisciplinary team approach, though, amputation prevention remains a challenging endeavor.


Leukocyte- and Platelet-rich Fibrin Treatment of Chronic Lower Extremity Ulcer in a Patient with Systemic Lupus Erythematosus: A Case Report - Hmpgloballearningnetwork.com
Article by Chunyu Li, Jing Zhang, Fen Wang, Weili Li, Qinqin Xu and Shiying Shao (Wuhan, China - Wounds). This case report provides a promising therapeutic strategy for the treatment of autoimmune-associated ulcers. More robust data from case series and RCTs are required to further evaluate the clinical efficacy of L-PRF in refractory ulcers in patients with autoimmune disease.


Platelet-rich Plasma Injection for Enterocutaneous Fistula: A Case Report - Hmpgloballearningnetwork.com
Article by Limin Bai, Gang Xu and Haijun Lin (Yangzhou, China - Wounds). The findings in this case report suggest that PRP can be used in the management of ECF in patients with no signs and symptoms of generalized sepsis or peritonitis to promote fistula closure and decrease time to healing.


Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On-Demand Removability for Wound Closure and MRSA-Infected Wound Healing - PubMed
Abstract by Xinchang Kang, Pengfei Guan, Cairong Xiao, Can Liu, Youjun Guan, Yeying Lin, Yu Tian, Kunyu Ren, Yanting Huang, Rumin Fu, Chengyun Ning, Lei Fan, Guoxin Tan and Lei Zhou (China - Adv Healthc Mater.).


Technology in wound care: digital health, remote monitoring, and AI - Medicaldevice-net.com
New advancements in remote monitoring devices and digital health technology can help supplement the efforts of healthcare workers.


Referral and Management of Pretibial Lacerations in Two District General Hospitals - Cureus.com
Article by Benjamin J. Jefferies, Lopa Patel and Atul Khanna (UK). This study showed that the majority of patients presenting with pretibial lacerations have minor wounds that can be effectively managed in the emergency department. However, those with considerably more injuries should be provided an early referral to specialist services, where they would ideally receive early surgery and comprehensive follow-up.


Wounds: Does Itchiness Mean Healing? - Healthnews.com
Article by Jennifer T. Trent. The human body is a remarkable machine, from its ability to heal and repair the damage we inflict on it daily. All our organ systems work in concert to keep us well. Skin is the largest organ, and it has the task of protecting and holding the rest of our organs inside our bodies. It works tirelessly to repair damage from simple cuts to deeper surgical wounds to keep us whole. During this repair process, itchiness may occur, but it is usually a normal healing response.


Ultrasound in Wound Healing - Physio-pedia.com
Therapeutic ultrasound is utilized by physical therapists to deliver a high frequency mechanical vibration to facilitate healing at a cellular level. Therapeutic ultrasound is often used by physiotherapists to reduce pain, increase circulation and increase mobility of soft tissues. Additionally, the application of ultrasound can be helpful in the reduction of inflammation, reducing pain and the healing of injuries and wounds.


The Sandwich Technique for Quick and Efficient Application of Negative Pressure Wound Therapy to the Feet and Hands: A Case Report - Hmpgloballearningnetwork.com
Article by Austin Rollins, Kristie Ho, Luis G. Fernandez, Marisse A. Lardizabal, Bryan Roth, Sean F. O’Keefe and Marc R. Matthews (USA - Wounds). In this case report, the authors propose a technique to apply either an acrylic drape or combination acrylic and soft silicone drape utilizing the “sandwich technique” to seal NPWT foam quickly and efficiently to the feet or hands.


Flap Application in Reconstructive Surgery to Manage Severe Radiation-induced Ulcers: A Case Series - Hmpgloballearningnetwork.com
Article by Hoang Thanh Tuan, Vu Quang Vinh, Tran Van Anh, Tong Thanh Hai, Tran Quang Phu and Trinh Tuan Dung (Hanoi, Vietnam - Wounds). The successful management of patients with severe complications suggests that immediate single-stage reconstruction may be a valuable option for managing radiation-induced ulcers.


Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing – From Experimental Studies to Clinical Practice - Nih.gov
Article by Mateusz Rybka, Łukasz Mazurek and Marek Konop (Warsaw, Poland - Life (Basel). In this review article, the authors focused on describing experimental and clinical studies exploring dressings containing either silver or silver nanoparticles, the results of which have been published in recent years.


A self-powered multifunctional dressing for active infection prevention and accelerated wound healing - Science.org
Article by Snigdha Roy Barman, Shuen-Wen Chan, Fu-Cheng Kao, Hsuan-Yu Ho, Imran Khan, Arnab Pal, Chih-Ching Huang and Zong-Hong Lin (Taiwan - Science Advances). The reported self-powered dressing holds great potential in facilitating personalized and user-friendly wound care with improved healing outcomes.


Use of a Novel Purified Reconstituted Bilayer Matrix for Treatment of Chronic Diabetic Foot Ulcers: A Retrospective Case Series - Hmpgloballearningnetwork.com
Article by Adam L. Isaac and Michael Tritto (USA - Wounds). Treatment of chronic DFUs with PRBM (porcine-derived bilayer matrix) is safe and efficient to achieve complete healing.


Graft of 3D Bioprinted Autologous Minimally Manipulated Homologous Adipose Tissue for the Treatment of Diabetic Foot Ulcer - Hmpgloballearningnetwork.com
Article by Ahmet Ç. Yastı, Ali E. Akgun, Aziz A. Surel, Jeehee Kim and Merve Akın (Turkey, Korea - Wounds). The authors' data indicate that AMHAT is beneficial in terms of ease of application, significant decrease in the wound surface area, no scarring compared to grafting, and full healing times.


A natural biological adhesive from snail mucus for wound repair - Nature.com
Article by Tuo Deng, Dongxiu Gao, Xuemei Song, Zhipeng Zhou, Lixiao Zhou, Maixian Tao, Zexiu Jiang, Lian Yang, Lan Luo, Ankun Zhou, Lin Hu, Hongbo Qin and Mingyi Wu (China - Nature Communications). The authors' provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.


A Game Changer for Diabetic Wound Treatment: New Material Speeds Up Healing - Scitechdaily.com
A new class of polymer that promotes healing in hard-to-treat diabetic wounds has been discovered by researchers from the University of Nottingham. The polymer gives instructions to both immune and non-immune cells, according to a study published in the journal Advanced Materials.


Role of autologous fat transplantation combined with negative-pressure wound therapy in the treatment of diabetic wounds in a rat model - Lww.com
Article by Hao Zhang, Min Zhou, Yu Wang, Dong Zhang, Baiwen Qi and Aixi Yu (Wuhan, China - Plastic and Reconstructive Surgery). Combining NPWT and autologous fat transplantation can enhance diabetic wound healing by improving wound inflammation and increasing wound vascularization.


Slough: What Is This Stuff? - Woundsource.com
Article by Dianne Rudolph. Nonviable tissue in the wound bed can be divided into 2 broad categories: slough and eschar. Although sometimes used interchangeably, it is vital to distinguish between them as they may require different management methods.


To Compress or Not to Compress: Practical Tips for Treating Lower Extremity Ulcers - Woundsource.com
Article by Emily Greenstein. We all know that compression therapy is the "gold standard" for the treatment of venous leg ulcers. However, how do we know if we should apply compression, how much compression, and what type of compression?


Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy - PubMed
Abstract by Rui He, Xiangyan Li, Kun Xie, Bing Wen and Xin Qi (Beijing, China - Front Surg.).


The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants - Mdpi.com
Article by Ghosoon Albahri, Adnan Badran, Akram Hijazi, Anis Daou, Elias Baydoun, Mohamad Nasser and Othmane Merah (Lebanon, Jordan, Qatar, France - Life). This review addresses the most often used medicinal plants from the Northern Hemisphere that facilitate the treatment of wounds, and also suggests viable natural alternatives that can be used in the field of wound care.


Effect of silver-containing hydrofiber dressing on burn wound healing: A meta-analysis and systematic review - Wiley.com
Article by Juan-juan Wu, Fan Zhang, Jing Liu, Hui-jun Yao and Yan Wang (Journal of Cosmetic Dermatology). Aquacel-Ag dressing can shorten wound healing time and effectively reduce inflammatory reactions in burn patients compared with silver sulfadiazine, but their safety still needs further exploration and analysis.


Printable hyaluronic acid hydrogel functionalized with yeast-derived peptide for skin wound healing - PubMed
Abstract by Pejman Ghaffari-Bohlouli, Julia Simińska-Stanny, Hafez Jafari, Mahta Mirzaei, Lei Nie, Christine Delporte and Amin Shavandi (Belgium, China - Int J Biol Macromol.).


Construction of Smart Biomaterials for Promoting Diabetic Wound Healing - Mdpi.com
Article by Chan Huang, Weiyan Yuan, Jun Chen, Lin-Ping Wu and Tianhui You (Guangzhou, China - Molecules). The authors' results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing.


Wound drainage measurements: a narrative review - Springer.com
Article by Terri Shih, Sarah Park, Linnea R. Thorlacius, Steven Daveluy, Amit Garg, Susanne D. Goegji, Joslyn S. Kirby, Barry M. McGrath, Peter T. Riis, Bente Villumsen, Kari Zalik, Gregor B. E. Jemec and Jennifer L. Hsiao (Archives of Dermatological Research). Development of a succinct drainage measurement tool for inflammatory skin diseases where drainage is a prominent symptom will improve monitoring of meaningful treatment response.


Herbal Products and Their Active Constituents for Diabetic Wound Healing – Preclinical and Clinical Studies: A Systematic Review - PubMed
Abstract by Anna Herman and Andrzej Przemysław Herman (Poland - Pharmaceutics).


Phytotherapeutic Agents Have Been Largely Used for Cutaneous Wound Healing - Imedpub.com
Article by Deborah P Merke (Groningen, The Netherlands - American Journal of Phytomedicine and Clinical Therapeutics). This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.


The Hype Around Photobiomodulation - Mcgill.ca
Article by Jonathan Jarry. The razzle-dazzle of cold lasers and red lights being used to treat just about anything offers two important lessons in how science works.


‘Who’s In Charge of a Wound?’: Interventionalists Should Play a Role - Tctmd.com
Article by Caitlin E. Cox. ISET speakers review the gains to be made by mastering the essentials, with the ultimate goal of avoiding amputation.


Offloading of diabetes-related neuropathic foot ulcers at Swedish prosthetic and orthotic clinics - PubMed
Abstract by Isabella Gigante, Elva Dröfn Sigurjónsdóttir, Gustav Jarl and Ulla Hellstrand Tang (Sweden, Iceland - Diabetes Metab Res Rev.).


Effect of a Hospital-Acquired Pressure Injury (HAPI) Risk Score on HAPI Rates in Patients With Vascular Diseases - PubMed
Abstract by Tonya Moyse, Jacqueline Bates, James F Bena, Shannon L Morrison and Nancy M Albert (Cleveland, USA - J Wound Ostomy Continence Nurs.).


Effects of exercise in treating patients with venous leg ulcers: A systematic review and meta-analysis - PubMed
Abstract by Qianting Zhang, Ling Lu, Jia Lin Song and Lu Wang (Nanjing, China - Int Wound J.).


Effectiveness of negative pressure wound therapy in patients with challenging wounds: a systematic review and meta-analysis - PubMed
Abstract by Mohamed Sa Shehata, Eshak Bahbah, Yousef El-Ayman, Ahmed H Abdelkarim, Ahmed R Abdalla, Ahmed Morshedy, Khaled Turkmani, Ishith Seth and Nimish Seth (Egypt, Syria, Australia - Wounds).


Decreased health care expenditure and average length of therapy with facilitated transition discharge program for patients receiving negative pressure wound therapy - PubMed
Abstract by Leila Boti, Laura Soloway, Deb Myers, Dinu Pillai and Javad Zabihi (St. Paul, USA - Wounds).


Epithelial Versus Granulation: Is It Full- or Partial-Thickness and What’s the Significance? - Woundsource.com
Article by Holly M. Hovan. Partial-thickness wounds are superficial and extend only through the first or second layers of the epidermis or dermis. The NPIAP further describes stage 2 pressure injuries as partial-thickness loss of skin with exposed dermis and pink or red, moist wound bed.


Evaluating the cost of managing patients with cellulitis in Wales, UK: A 20-year population-scale study - PubMed
Abstract by Ioan Humphreys, Ashley Akbari, Rowena Griffiths, Dave Graham-Woollard, Karen Morgan, Rhian Noble-Jones, Marie Gabe-Walters and Melanie Thomas (Swansea, UK - Int Wound J.).


Surgical Site Infection Prevention: A Review - PubMed
Abstract by Jessica L Seidelman, Christopher R Mantyh and Deverick J Anderson (Durham, USA - JAMA).


Clinical, histological, immunohistochemical and biomolecular analysis of hyaluronic acid in early wound healing of human gingival tissues: A randomized, split-mouth trial - Wiley.com
Abstract by Andrea Pilloni, Lorenzo Marini, Gagliano Nicoletta, Elena Canciani, Dellavia Claudia, Laura Brigida Cornaghi, Ezio Costa and Mariana A. Rojas (Italy - Journal of Periodontology).


Adult skin fibroblast state change in murine wound healing - Nature.com
Article by Fatma Z. Gharbia, Ahmed S. Abouhashem, Yomna A. Moqidem, Ahmed A. Elbaz, Ahmed Abdellatif, Kanhaiya Singh, Chandan K. Sen and Hassan M. E. Azzazy (Egypt, USA, Germany - Scientific Reports). Analysis of murine transcriptomic skin wound healing datasets suggested a subset of fibroblasts capable of inducing EMT and further inferred drugs that might be tested as potential candidates to induce wound closure.


Review on Extraction, Modification, and Synthesis of Natural Peptides and Their Beneficial Effects on Skin - Mdpi.com
Article by Jiabing An, Ivan Stève Nguepi Tsopmejio, Zi Wang and Wei Li (Changchun, China - Molecules). This review sorted and summarized the relevant literature about peptides during the past decade. Recent works on the extraction, modification and synthesis of peptides were reviewed.


A Comparative Study Between Use of Topical Honey and Edinburgh University’s Solution of Lime (EUSOL) Dressing in Necrotizing Fascitis Wounds - Cureus.com
Article by Lajpat Rai, Muhammad Ali Ghufran, Khursheed Ahmed Samo, Munawar Hussain Mangi, Jahanzaib Babar and Mujeeb Rehman Abbasi (Karachi, Pakistan). While managing necrotizing soft tissue infection wounds with honey, honey promotes faster wound healing and shorter hospital stays compared to EUSOL.


Bacterial Motility and Its Role in Skin and Wound Infections - Mdpi.com
Article by Katarzyna Zegadło, Monika Gieroń, Paulina Żarnowiec, Katarzyna Durlik-Popińska, Beata Kręcisz, Wiesław Kaca and Grzegorz Czerwonka (Kielce, Poland - IJMS). The authors present the five main types of bacterial motility, their molecular mechanisms, and examples of bacteria that utilise them. Bacterial migration mechanisms can be considered not only as a virulence factor but also as a target for antibacterial therapy.


Alginate and nanocellulose dressings with extract from salmon roe reduce inflammation and accelerate healing of porcine burn wounds - Oup.com
Article by Karin M Gilljam, Patrik Stenlund, Simon Standoft, Sisse Bindslev Andersen, Kari Kaaber, Henrik Lund and Karl R K Bryn (Norway, Sweden, Denmark - Journal of Burn Care & Research). The results from this study indicate that Collex is a potent dressing for treatment of burn wounds, with the anti-inflammatory effect of HTX beneficial in the initial phase, and the moist qualities of the hydrogel favorable both in the initial and the proceeding proliferative phase of wound healing.


Pressure ulcers in hospital patients: incidence and risk factors - Magonlinelibrary.com
Abstract by Roberta Rapetti, Antonio Pansera, Simona Visca, Manuela Martolini, Sara Antoniotti, Fabio Bertoncini, Monica Cirone and Sara Visca (Italy - J Wound Care).


Granulocyte-macrophage colony-stimulating factor: Conductor of the wound healing orchestra? - Wiley.com
Article by J. Karim Ead and David G. Armstrong (Los Angeles, USA - International Wound Journal). The recognized beneficial role of GM-CSF in immune regulation across many studies provides a rationale for the initiation of the ongoing randomized controlled trials using GM-CSF.


Prospective randomised placebo-controlled trial assessing the efficacy of silver dressings to enhance healing of acute diabetes-related foot ulcers - Springer.com
Abstract by Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch and Paul Wraight (Melbourner, Australia - Diabetologia).


Bioinspired Strategies for Wound Regeneration - PubMed
Abstract by Hans I-Chen Harn, Jeffrey M Davidson and Cheng-Ming Chuong (USA - Cold Spring Harb Perspect Biol.).


Preliminary evidence supporting a new enzymatic debridement product for use in chronic wounds - Wiley.com
Article by David M. Fairlamb, Bela Kelety, Anke Bachert, Anika Scholtissek, Richard D. Jones, Stephen C. Davis and Robert S. Kirsner (UK, Germany, USA - International Wound Journal). The authors showed that higher concentrations of the enzyme in a formulated proprietary gel, significantly reduced MRSA counts over a period of 2 to 14 days, and significantly improved the vascularity of the wound at 14 days. Together, these data support the potential for this maggot-derived proteolytic enzyme as a clinically effective debriding agent.


State of the Art of Hydrogel Wound Dressings Developed by Ionizing Radiation - Mdpi.com
Article by Maria Demeter, Anca Scărișoreanu and Ion Călina (Măgurele, Romania - Gels). The evolution and current status of research on hydrogel wound dressings obtained exclusively through production by ionizing radiation are discussed in this paper review, along with the preparation methods, properties, standard characterization techniques, and their applications in wound dressing.


SCI-QOL and WOUND-Q Have the Best Patient-reported Outcome Measure Design: A Systematic Literature Review of PROMs Used in Chronic Wounds - Lww.com
Article by van Tert C. Alphen, Floor ter Brugge, Emiel L. W. G. van Haren, Maarten M. Hoogbergen and Hinne Rakhorst (The Netherlands - Plastic and Reconstructive Surgery - Global Open). Thirty-three condition-specific PROMs were found. Only the SCI-QOL and the WOUND-Q rated very good in PROM design. The WOUND-Q is the only condition-specific PROM, which can be used in all types of chronic wounds in any anatomic location.


Leukocyte- and Platelet-rich Fibrin Treatment of Chronic Lower Extremity Ulcer in a Patient with Systemic Lupus Erythematosus: A Case Report - Hmpgloballearningnetwork.com
Article by Chunyu Li, Jing Zhang, Fen Wang, Weili Li, Qinqin Xu and Shiying Shao (Wuhan, China). This case report provides a promising therapeutic strategy for the treatment of autoimmune-associated ulcers.


How to Identify Pressure Injuries in Skin of Color - Woundsource.com
Article by Janet Wolfson. A 55-year-old African American male was admitted to our inpatient rehabilitation facility with a right trochanter stage 4 pressure injury, sacral stage 3, and left below the knee amputation with comorbid diabetes mellitus and end-stage renal disease.


Wound repair using discarded skin tissue from the rolled edge of pressure injury: a feasibility study of five cases - PubMed
Abstract by Zhi'yuan Shi, Min'hui Zhu, Ming Zhang and Xiang'bo Ye (Beijing, China - Wounds).


The pressure time integral: An underused, clinically significant parameter as a determinant of neuropathic ulceration in diabetes - PubMed
Abstract by Erica Bartolo, Claudia Giacomozzi, David V Coppini and Alfred Gatt (Malta, Italy - Gait Posture).


The Effect of Vibration on the Acceleration of Wound Healing of Diabetic Neuropathic Foot Ulcer: A Prospective Experimental Study on Human Patients - Mdpi.com
Article by Sitti Syabariyah, Elly Nurachmah, Budiman Darmo Widjojo, Sabarinah Prasetyo, Hiromi Sanada, Irianto, Gojiro Nakagami,Suriadi, Tutur Kardiatun and Urfa Khairatun Hisan (Indonesia, Japan - Healthcare). The authors' findings suggested that vibration wound therapy enhances diabetic neuropathic foot ulcer healing in terms of healing rate, wound closure area, healing score, and elevated nitric oxide level.


Nonclinical regulatory considerations for wound-healing growth factors - Wiley.com
Abstract by Judi Weissinger (Drug Development Research).


Selecting appropriate compression for lymphedema patients: American Vein and Lymphatic Society position statement - PubMed
Abstract by Heather Hettrick, Suzie Ehmann, Brandy McKeown, Dean Bender and John Blebea (USA - Phlebology).


Wound Healing Properties of Natural Products: Mechanisms of Action - Mdpi.com
Article by Marilyn S. Criollo-Mendoza, Laura A. Contreras-Angulo, Nayely Leyva-López, Erick P. Gutiérrez-Grijalva, Luis Alfonso Jiménez-Ortega and J. Basilio Heredia (Culiacán, Mexico - Molecules). The authors observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, they also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration.


Comparison of Deep Partial Thickness Burns Wound Healing with Resveratrol Gel and Paraffin Gauze in Wistar Rats - Oamjms.eu
Article by Paulina Magdalena, I Made Suka Adnyana, I Gusti Putu Hendra Sanjaya, Agus Roy Rusly Hariantana Hamid and Ni Wayan Winarti (Bali, Indonesia - Macedonian Journal of Medical Sciences). Topical administration of resveratrol gel accelerates the epithelialization process, which increases the number of angiogenesis, fibroblasts, and collagen deposition in deep partial thickness burns compared to paraffin gauze.


An Insight into the Potential Mechanism of Bioactive Phytocompounds in the Wound Managemen - Phcogrev.com
Abstract by Manisha Khaire, Jagriti Bigoniya and Papiya Bigoniya (India, UK - Pharmacognosy Reviews).


Activation of healing and reduction of pain by single-use automated microcurrent electrical stimulation therapy in patients with hard-to-heal wounds - Wiley.com
Article by Peter Kurz, Gabriele Danner, Jean-Paul Lembelembe, HariKrishna K. R. Nair and Robin Martin (International Wound Journal). In this article, the authors show that a high proportion of wounds respond to single-use microcurrent EST which makes the case for the wider introduction of microcurrent EST for wound healing and pain relief.


Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections – Prospective Cohort Study - Mdpi.com
Article by Amadou Bocoum, Senna J. J. M. van Riel, Soumana Oumar Traoré, Elisabeth Florine Ngo Oum II, Youssouf Traoré, Augustin Tioukani Thera, Seydou Fané, Bakary Tientigui Dembele and Niels A. J. Cremers (Mali, The Netherlands - Antibiotics). MGH is a potent alternative treatment to antibiotics and povidone-iodine because while the complication risk is similar, MGH has additional benefits. MGH promotes wound healing and does not bear the risk of resistance.


Curcumin in Wound Healing – A Bibliometric Analysis - Mdpi.com
Article by Faiza Farhat, Shahab Saquib Sohail, Farheen Siddiqui, Reyazur Rashid Irshad and Dag Øivind Madsen (India, Saudi Arabia, Norway - Life). The authors' results indicate a significant increase in both research and publications on the wound-healing properties of curcumin.


Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds - Nature.com
Article by Rui Sun, Chunyan Liu, Jian Liu, Siyuan Yin, Ru Song, Jiaxu Ma, Guoqi Cao, Yongpan Lu, Guang Zhang, Zhenjie Wu, Aoyu Chen and Yibing Wang (Shandong, China - Scientific Reports). Naringenin promoted wound healing in mice in vivo by inhibiting wound inflammation. Furthermore, in vitro experiments showed that a low naringenin concentration did not significantly affect normal skin cell viability and cell apoptosis; a high naringenin concentration was cytotoxic and reduced cell survival by promoting apoptosis.


Tapping into a tumor's power to heal non-healing wounds - Healthcare-in-europe.com
Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells for a good purpose: to accelerate diabetic wound healing.


Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers - Springer.com
Abstract by Katarína Valachová, Karol Švík, Rastislav Jurčík, Ľubomír Ondruška, Csaba Biró and Ladislav Šoltés (Chemical Papers).


Healing Effect of Plantago major and Photodynamic Therapy Combination on Skin Wounds - Scialert.net
Article by Omed Omer Rahim, Hawro D.I. Masseh, Nadia Abdulkarim Salih and Dara Dastan (Science Alert). The evidence from this study suggested that the combination of traditional and modern wound repair approaches could result in more favorable outcomes.


Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers - PubMed
Abstract by Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu and Wei Song (China - Front Pharmacol.).


Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer - Wiley.com
Article by Yuan Xiong, Qian Feng, Li Lu, Kangkang Zha, Tao Yu, Ze Lin, Yiqiang Hu, Adriana C. Panayi, Vahideh Nosrati-Ziahmagi, Xiangyu Chu, Lang Chen, Mohammad-Ali Shahbazi, Bobin Mi and Guohui Liu (Advanced Functional Materials). By linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future.


Data-Driven Practice Management: How to Use Patient Data to Improve Care - Woundsource.com
As the health care industry moves from volume-driven to value-based care, clinicians are looking for ways to improve care and outcomes while reducing costs. Data-driven practice management has emerged as a key strategy for cost-effective quality care.


Consistent pressure ulcer prevention practice: The effect on PU prevalence and PU stages, and impact on PU prevention - A quasi-experimental intervention study - PubMed
Abstract by Sirpa Mäki-Turja-Rostedt, Helena Leino-Kilpi, Marita Koivunen, Tero Vahlberg and Elina Haavisto (Finland - Int Wound J.).


Major impact of moist wound healing on autologous tissue regeneration: A review of ulcer treatment - Wiley.com
Article by Kenji Yamamoto, Senri Miwa, Tomoyuki Yamada, Shuji Setozaki, Mamoru Hamuro, Shunji Kurokawa and Sakae Enomoto (Health Science Reports). Moist wound healing maximizes the autologous regeneration of tissues by preserving the microbiota balance, which may be a valuable option for wound management.


Mesenchymal stem cell therapy for wound healing: An update to 2022 - Bmrat.org
Article by Phat Duc Huynh, Quynh Xuan Tran, Sao Thi Nguyen, Vy Quang Nguyen and Ngoc Bich Vu (Vietnam - Biomedical Research and Therapy). This review seeks to introduce the skin system and its related disorders; highlight the common characteristics and mechanisms of mesenchymal stem cells (MSCs); and analyze updated clinical applications and experiments to date in MSC therapy for regenerative biomedicine and skin diseases.


Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds - Mdpi.com
Article by Wan-Hua Tsai, Chia-Hsuan Chou, Tsuei-Yin Huang, Hui-Ling Wang, Peng-Ju Chien, Wen-Wei Chang and Hsueh-Te Lee (Taiwan - Cells). The authors' study offers a new therapeutic potential of the heat-killed format of Lactobacillus as an alternative approach to treating skin healing disorders.


The use of epidermal growth factor in dermatological practice - Wiley.com
Article by Sun Hye Shin, Young Gue Koh, Woo Geon Lee, Joon Seok and Kui Young Park (International Wound Journal). The authors conducted a literature search of PubMed/Medline and Google Scholar databases to retrieve published literature related to rhEGF and summarised the effects of rhEGF in the treatment of various wound types, radiotherapy or chemotherapy-related skin reactions, atopic dermatitis, skin aging, and post-inflammatory hyperpigmentation.