Acute Inflammation in Tissue Healing - Mdpi.com
Article by Amro M. Soliman and Daniel R. Barreda (Edmonton, Canada - IJMS).
In this review, the authors summarize the contributions of key cellular and molecular components to the acute inflammatory process and the effective and timely transition toward activation of tissue repair mechanisms.
The Effectiveness of Negative Pressure Therapy: Nursing Approach - PubMed
Abstract by Álvaro Astasio-Picado, María Dolores Murcia Montero, Miriam López-Sánchez, Jesús Jurado-Palomo, Paula Cobos-Moreno and Beatriz Gómez-Martín (Spain - J Pers Med.).
Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities - PubMed
Abstract by Gamze Akkus and Murat Sert (Adana, Turkey - World J Diabetes).
Design and Development of Wound Dressing by Using Commercial Antiseptic Liquid - Springer.com
Abstract by Subrata Ghosh, Kaliraj Balasubramaniam and Prasanta Das (Journal of The Institution of Engineers (India): Series E).
Sequential Wound Therapy and Negative Pressure Wound Therapy - Consultant360.com
In this podcast, Robert Klein speaks about the effects of negative pressure wound therapy on wound healing, new technologies and treatment approaches, and what primary care providers and emergency medical physicians should know about negative pressure wound therapy.
Within-patient randomised clinical trial exploring the development of microskin implantation in the treatment of pressure ulcers - Wiley.com
Article by Ming Zhang, Jiachen Sun, Minhui Zhu, Tianjun Sun, Zhiyuan Shi, Lu Zhang, Xingtong Wang, Yaoyao Song, Xiangbo Ye, Yuanxin Deng, Wanli Chu and Chuanan Shen (International Wound Journal).
As a complementary palliative treatment, supplementary microskin implantation is effective and well tolerated.
Efficacy of Graphene-Based Nanocomposite Gels as a Promising Wound Healing Biomaterial - Mdpi.com
Article by Dilip Kumar Shanmugam, Yasasve Madhavan, Aashabharathi Manimaran, Gobi Saravanan Kaliaraj, Karthik Ganesh Mohanraj, Narthana Kandhasamy and Kamalan Kirubaharan Amirtharaj Mosas (India, Slovakia - Gels).
It is suggested that GO/rGO-based aloe vera gel can be recommended as a promising candidate for wound healing applications.
In vitro evaluation of immunomodulatory, anti-diabetic, and anti-cancer molecular mechanisms of Tribulus terrestris extracts - Nature.com
Article by Abdullah Khalid, Tariq Nadeem, Muhammad Asaf Khan, Qurban Ali and Muhammad Zubair (Pakistan - Scientific Reports).
It is expected that this study will lay a foundation and lead to the development of efficient but low-cost, natural herbs extract-based dressing/ointment for diabetic patients and identify potential drug metabolites to treat out-of-whack inflammatory responses involved in cancer onset, progression, and metastasis.
Bioprinted Hydrogels for Fibrosis and Wound Healing: Treatment and Modeling - Mdpi.com
Article by Jason L. Guo and Michael T. Longaker (Stanford, USA - Gels).
As biological research begins to uncover the spatial biological features that underlie fibrosis and wound healing, bioprinting offers a powerful toolkit to recapitulate spatially defined pro-regenerative and anti-fibrotic cues for an array of translational applications.
Add Bacteria to Control Bacteria: Growing Evidence To Consider in Wound Care - Hmpgloballearningnetwork.com
Article by David G. Armstrong.
A recent study in Pharmaceutics provides more cogent information to support the contention that we might consider adding bacteria in the world of wound care, rather than just removing it.
Transcriptional changes in human palate and skin healing - Wiley.com
Abstract by Trevor R. Leonardo, Lin Chen, Megan E. Schrementi, Junhe Shi, Phillip T. Marucha, Kimberly Glass and Luisa A. DiPietro (USA - Wound Repair and Regeneration).
Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing – From Experimental Studies to Clinical Practice - Mdpi.com
Article by Mateusz Rybka, Łukasz Mazurek and Marek Konop (Warsaw, Poland - Life).
In this review article, the authors focused on describing experimental and clinical studies exploring dressings containing either silver or silver nanoparticles, the results of which have been published in recent years.
In vivo observations of biofilm adhering to a dialkylcarbamoyl chloride-coated mesh dressing when applied to diabetes-related foot ulcers: A proof of concept study - Wiley.com
Article by Matthew Malone, Michael Radzieta, Saskia Schwarzer, Amy Walker, Justin Bradley and Slade O. Jensen (International Wound Journal).
Wound dressings for use in hard-to-heal wounds should be used as an adjunct to a good standard of care which includes debridement and wound bed preparation.
Coagulation side effects of enzymatic debridement in burned patients - PubMed
Abstract by Pablo Pfister, Pedro David Garcia Wendel, Bong Sung Kim, Reto Andreas Schuepbach, Peter Steiger, Giovanni Camen and Philipp Karl Buehler (Switzerland - Burns).
Effect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers - Mdpi.com
Article by Eunbin Kim, Seoyoon Ham, Bok Ki Jung, Jin-Woo Park, Jihee Kim and Ju Hee Lee (Korea - IJMS).
The authors' results suggest that baicalin could serve as a promising agent for the treatment of pressures ulcers.
Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages - Sciencedirect.com
Article by Sjors Maassen, Britt Coenen, Melina Ioannidis, Karl Harber, Pieter Grijpstra, Jan Van den Bossche and Geertvan den Bogaart (The Netherlands - Redox Biology).
The authors' results indicate that 4-OI lowers macrophage inflammation, likely promoting a more wound-resolving phenotype.
Antibacterial smart hydrogels: New hope for infectious wound management - Dtu.dk
Article by Zahra Aliakbar Ahovan, Zahra Esmaeili, Behnaz Sadat Eftekhari, Sadjad Khosravimelal, Morteza Alehosseini, Gorka Orive, Alireza Dolatshahi-Pirouz, Narendra Pal Singh Chauhan l, Paul A. Janmey, Ali Hashemi , Subhas C. Kundu and Mazaher Gholipourmalekabadi (Iran, USA, Spain, Singapore, Denmark, India, Portugal - Materials Today Bio).
This paper aims to critically review recent pre-clinical and clinical advances in using smart hydrogels against skin wound infections and propose the next best thing for future trends.
Patient-centered Outcomes for Individuals with a Venous Leg Ulcer: A Scoping Review - PubMed
Abstract by Michelle Lazar, Sherry Ershadi, Laura Bolton and Tania Phillips (Adv Skin Wound Care).
The importance of inflammation control for the treatment of chronic diabetic wounds - Wiley.com
Article by Anna L. Worsley, Dennis H. Lui, Winnie Ntow-Boahene, Wenhui Song, Liam Good and Janice Tsui (International Wound Journal).
This review describes the chronic inflammation pathophysiologies in diabetic ulcers and treatment options that may help address this dysfunction either directly or indirectly. The authors suggest that treatments to reduce inflammation within these complex wounds may help trigger healing.
Healing Time of Skin Ulcers in Homecare Residents in the Province of Reggio Emilia, Northern Italy - PubMed
Abstract by Inga Iamandii, Abram Beatrice Kouassi, Davide Simonazzi, Cristina Marchesi, Marco Vinceti and Tommaso Filippini (Italy, USA - Life (Basel).
The Effect of Negative Pressure on Wound Healing and Regeneration in Closed Incisions under High Tension: Evidence from Animal Studies and Clinical Experience - Mdpi.com
Article by Hui-Yi Hsiao, Wei-Chuan Hsieh, Frank Chun-Shin Chang, Jia-Wei Liu, Wen-Ling Kuo, David Chon-Fok Cheong and Jung-Ju Huang (Taiwan, JCM).
The treatment of closed incisions under tension with iNPWT clinically enhances wound healing and tissue regeneration and with histological evidence.
A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients - Nature.com
Article by Zhe Fu, Huiling Sun, Yutong Wu, Chao Li, Yinglei Wang, Yixiang Liu, Yilin Li, Junxu Nie, Dandan Sun, Yingxuan Zhang, Naixin Liu, Kun Guo, Saige Yin, Qiuye Jia, Ying Yang, Li He, Ying Wang and Xinwang Yang (Kunming, China - NPG Asia Materials).
The hydrogel presents a novel therapeutic strategy for clinical chronic skin wound (diabetic ulcer) healing.
Hypertonic saline solution 5% as an effective cost-beneficial alternative to normal saline for wound healing in patients with diabetic lower-extremity ulcers: a randomized controlled trial - Springer.com
Abstract by Bizhan Ziaian, Samad Khezri, Armin Amirian, Keivan Ranjbar, Reza Shahriarirad and Mariye Eskandari Kohnaki (Journal of Diabetes & Metabolic Disorders).
Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation - Nature.com
Article by Isabelle Petit, Ayelet Levy, Soline Estrach, Chloé C. Féral, Andrea Gonçalves Trentin, Florent Dingli, Damarys Loew, Jieqiong Qu, Huiqing Zhou, Clotilde Théry, Céline Prunier, Daniel Aberdam and Olivier Ferrigno (France, The Netherlands - Scientific Reports).
The authors' results reveal a novel aspect of extracellular vesicle (EV) function and suggest EVs as a potential tool for delivering FGF2 in skin healing therapies.
Amino acid buffered hypochlorite facilitates debridement of porcine infected burn wounds - PubMed
Abstract by Larsson Alexander P, Rakar Jonathan, Kratz Gunnar and Junker Johan P E (Sweden - Burns).
The Associations between Diode Laser (810 nm) Therapy and Chronic Wound Healing and Pain Relief: Light into the Chronic Wound Patient's Life - Wiley.com
Abstract by Di Tang, Chunmei Liu, Xia Chen, Xian Lv, Lili Yuan, Dongdong Xue and Huapei Song (China - Wound Repair and Regeneration).
Hypertrophic Scars and Keloids: Similarities and Differences - Healthline.com
Hypertrophic scars and keloids both form due to excess collagen during wound healing. But hypertrophic scars stay within the confines of the wound, while keloids can grow beyond. Keloids are also much more difficult to treat.
Merry Mistletoe: Healing Value Beyond the Holiday Season - Healthline.com
Article by Christine Miller.
Bundles of mistletoe will no doubt appear in many homes across the world this holiday. In this blog, after learning about its therapeutic offerings, one may never look at mistletoe again, especially after learning these therapeutic properties related to wound care.
Is caring for pressure ulcers in the intensive care unit in Spain still a challenge? A qualitative study on nurses' perceptions - PubMed
Abstract by Claudia Acosta-Hernández, Rafael-Jesús Fernández-Castillo, Manuel Montes-Vázquez and María-Dolores González-Caro (Seville, Spain - J Tissue Viability).
Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing - Mdpi.com
Article by Chantal M. Wallenwein, Verena Weigel, Götz Hofhaus, Namrata Dhakal, Wolfgang Schatton, Svetlana Gelperina, Florian K. Groeber-Becker, Jennifer Dressman and Matthias G. Wacker (Germany, Singapore - IJMS).
Freeze-drying led to an easy-to-use formulation with optimal stability characteristics and a highly reproducible manufacturing process.
Physiotherapists' knowledge on pressure ulcer prevention - PubMed
Abstract by Ozlem Ozcan and Hayriye Kul Karaali (Manisa, Turkey - Int Wound J.).
Managing malignant wounds in patients receiving palliative care - Rcni.com
Abstract by Lynn Cornish (Yeovil, UK - NursingStandard).
Therapeutic and pro-healing potential of advanced wound dressings loaded with bioactive agents - Futuremedicine.com
Abstract by Lavanya Khullar, Kusum Harjai and Sanjay Chhibber (Future Medicine).
Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks - Mdpi.com
Article Kamarul Ariffin Khalid, Ahmad Faris Mohd Nawi, Nuraqilah Zulkifli, Md. Abul Barkat and Hazrina Hadi (Malaysia, Saudi Arabia - Life).
Aging has a significant impact on the skin’s healing function by prolonging the inflammatory phase and increasing the production of reactive oxygen species (ROS). This shifts the healing process towards having more protein degradation, which can lead to chronic wound healing with an abundance of complications.
Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts - Tandfonline.com
Article by Soomin Kim, Yujin Kim, Shin-Hye Yu, Seo-Eun Lee, Jong Hyeok Park, Gayoung Cho, Chul Choi, Kyuboem Han, Chun-Hyung Kim and Young Cheol Kang (Seoul, Korea - Platelets).
The authors' results suggest that pl-MT transfer might be used as a potential therapeutic strategy for wound repair.
World-first topical gene therapy gel heals decades-old wounds - Newatlas.com
Article by Rich Haridy.
A Phase 3 trial testing the world's first topical gene therapy has reported extraordinary results in children suffering from a rare blistering skin disease. The gene therapy gel was seen to completely heal wounds that had been open for years.
Improved Optical Tissue Model for Tissue Oximetry Imaging Applications - PubMed
Abstract by Gennadi Saiko (Toronto, Canada - Adv Exp Med Biol.).
Ozone therapy for skin diseases: Cellular and molecular mechanisms - Wiley.com
Article by Liyao Liu, Liyue Zeng, Lihua Gao, Jinrong Zeng and Jianyun Lu (International Wound Journal).
This review article aims to summarise and explore the possible molecular biological mechanisms of ozone in cutaneous diseases and provide compelling theoretical evidence for the application of ozone in cutaneous diseases.
The Influence of Novel, Biocompatible, and Bioresorbable Poly(3-hydroxyoctanoate) Dressings on Wound Healing in Mice - Mdpi.com
Article by Martyna Seta, Katarzyna Haraźna, Kaja Kasarełło, Daria Solarz-Keller, Agnieszka Cudnoch-Jędrzejewska, Tomasz Witko, Zenon Rajfur and Maciej Guzik (Poland - IJMS).
The authors' results confirm that dressings based on P(3HO) are safe, do not induce an inflammatory response, reduce the expression of pro-inflammatory cytokines, provide adequate wound moisture, support angiogenesis, and, thanks to their hydrophobic characteristics, provide an ideal protective barrier.
Role of fibroblast plasticity and heterogeneity in modulating angiogenesis and healing in the diabetic foot ulcer - Springer.com
Abstract by Vikrant Rai, Rebecca Moellmer and Devendra K. Agrawal (Molecular Biology Reports).
Development of an implantable three-dimensional model of a functional pathogenic multispecies biofilm to study infected wounds - Nature.com
Article by Camila Cárdenas-Calderón, Valentina Veloso-Giménez, Tamara González, Aniela Wozniak, Patricia García, Sebastián San Martín, Juan F. Varas, Ivo Carrasco-Wong, Mario Vera and José Tomás Egaña (Chile - Scientific Reports).
This functional and implantable 3D biofilm model allows to study host response during infection, providing a useful tool for infected wounds therapy development.
Clinical Effect of Photobiomodulation on Wound Healing of Diabetic Foot Ulcers: Does Skin Color Needs to Be Considered? - Hindawi.com
Article by Thabo Dhlamini and Nicolette Nadene Houreld (Doornfontein, South Africa - Journal of Diabetes Research).
All the clinical trials adopted for this review show evidence that PBM together with conventional treatment results in an increased healing rate of DFUs; however, only one study adjusted their protocol according to skin color.
Impact of negative pressure wound treatment on incidence of surgical site infection in varied orthopedic surgeries: A systematic review and meta-analysis - PubMed
Abstract by Song Yuan, Tingjiu Zhang, Dong Zhang, Qin He, Meiting Du and Fanwei Zeng (China - Int Wound J.).
A Systematic Review of Oral Nutritional Supplement and Wound Healing - Elsevier.com
Abstract by Ghazal S. Daher, Karen Y. Choi, Jeffery W. Wells and Neerav Goyal (Pennsylvania, USA - Annals of Otology, Rhinology and Laryngology).
Evaluation of Wound Healing Activity of Polyherbal Skin Care Cream - Jdtonline.info
Article by Abhinay Kumar Dwivedi and Hemant Kumar Sharma (Sehore, India - Journal of Drug Delivery and Therapeutics).
Formulation F4 was found as effective wound healing agent while compared with the negative control, due to significant reduction in epithelialization period and wound contraction, the formulation F4 could be used as wound healing agent for cure and management of wound.
Study on the effects of alternating capacitive electric fields with different frequencies on promoting wound healing - Sciencedirect.com
Article by Yunxue Jia, Junwei Xu, Qiusheng Shi, Lisha Zheng, Meili Liu, Ming Wang, Ping Li and Yubo Fan (Beijing, China - Medicine in Novel Technology and Devices).
The enhancements in cell activity, migration rate and M2-type polarizability indicated that 58 mV/mm ACEFs especially at 60 Hz possessing potentially affirmative applications for wound healing without the risks of secondary damage and microenvironment imbalance.
Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta-analysis of randomised controlled trials - Wiley.com
Article by Guoqi Wang, Haiyan Xu, Gaoxiang Xu, Hao Zhang, Zhirui Li and Daohong Liu (China, USA - International Wound Journal).
The addition of instillation to NPWT could improve clinical outcomes regarding the number of surgeries and dressing changes, and wound area after treatment in patients with multiple wound types. However, because of the heterogeneity these conclusions still need to be further validated.
Global consensus on incision care and dressing selection in surgical wounds - Molnlycke.com
Incision care has been an area of little focus in the past with a vast majority of patients still being treated the same way today as 50 years ago – with dressings that are stiff, low absorbing, skin damaging, painful to remove and do not allow the patient to shower. This is unacceptable and opinion needs to change to improve incision care in the world.
Anethum Graveolens Leaves Extract Accelerate Wound Healing In Vitro and In Vivo - Biomedpharmajournal.org.com
Article by Zahra A. Amin (Erbil, Iraq - Biomedical and Pharmacology Journal).
The author's results proved that the topical application of Anethum graveolens plant extract quicken the wound healing process.
Efficacy and safety of traditional Chinese medicine external washing in the treatment of postoperative wound of diabetes complicated with anal fistula: Study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial - Frontiersin.org
Article by Jian Kang, Ya Liu, Sihan Peng, Xiao Tang, Lu Liu, Ziyan Xie, Yuchi He and Xiyu Zhang (Chengdu, China - Front. Pharmacol.).
The authors report this carefully designed clinical trial to assess the efficacy and safety of JSD in the treatment of postoperative wounds in diabetic patients with anal fistula.
Reoxygenation Modulates the Adverse Effects of Hypoxia on Wound Repair - Mdpi.com
Article by Que Bai, Qian Gao, Fangfang Hu, Caiyun Zheng, Na Sun, Wenting Chen, Jinxi Liu, Yanni Zhang, Xianglong Wu and Tingli Lu (Xi’an, China - IJMS).
The authors' work confirmed that reoxygenation significantly increases the progression of wound healing in mice. Therefore, reoxygenation can effectively alleviate the adverse effects of hypoxia, so it can be used as a strategy for the subsequent treatment of hypoxic wounds.
Wound Management: Promoting Patient Adherence through Education - Woundsource.com
Article by Holly Hovan.
The decisions patients make on a daily basis, along with activities (time spent in bed, chair, with legs dependent, etc), have a significant impact on healing outcomes, independent of the wound care professional.
Benefits of a Portable, Mechanical Negative Pressure Device for Pediatric Patients - Woundsource.com
Article by Elizabeth Dechant.
There is ever-increasing literature to support the use of NPWT to treat wounds effectively and safely in even the youngest patients. Some specific benefits of NPWT for pediatric and adolescent patients include decreased frequency of dressing changes, as well as a dressing that is occlusive and unlikely to be removed by the patient.
Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing - Mdpi.com
Article by Łukasz Mazurek, Mateusz Szudzik, Mateusz Rybka and Marek Konop (Warsaw, Poland - Biomaterials).
In this review, the authors summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings.
Evidence-based management of keloids and hypertrophic scars in dermatology - Springer.com
Abstract by Emily Y. Kim, Aamir Hussain and Amor Khachemoune (Archives of Dermatological Research).
Prophylactic negative pressure wound therapy following colorectal perforation: defining the risk factors for delayed wound healing - Springer.com
Abstract by Jun Kawashima, Kota Sahara and Shigeru Yamagishi (Fujisawa, Japan - Surgery Today).
Efficacy and safety of external tissue expansion technique in the treatment of soft tissue defects: a systematic review and meta-analysis of outcomes and complication rates - Oup.com
Article by Xirui Tong, Jianyu Lu, Wei Zhang, Siqiao Wang, Runzhi Huang, Xianliang Zhang, Jie Huang, Yushu Zhu, Shichu Xiao, Shizhao Ji and Zhaofan Xia (China - Burns & Trauma).
The authors' systematic review is the first to demonstrate the efficacy and safety of external tissue expansion in the management of soft tissue defects.
Semi-occlusive dressing therapy versus surgical treatment in fingertip amputation injuries: a clinical study - Springer.com
Article by Tatjana Pastor, Patricia Hermann, Luzian Haug, Boyko Gueorguiev, Torsten Pastor and Esther Vögelin (Switzerland - European Journal of Trauma and Emergency Surgery).
Semi-occlusive dressing for fingertip injuries is a very successful procedure and shall be preferred over surgical treatment in most cases.
Cutaneous effects of photobiomodulation with 1072 nm light - Springer.com
Abstract by Jessica Mineroff, Evan Austin and Jared Jagdeo (Archives of Dermatological Research).
Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia - Mdpi.com
Article by Natalija Čutović,Tatjana Marković, Marina Kostić, Uroš Gašić, Željana Prijić, Xiuxia Ren, Milan Lukić and Branko Bugarski (Serbia, China - Pharmaceuticals).
This study is the first step towards the safe use of the aqueous extracts of P. tenuifolia petals for therapeutic skin treatments.
Effectiveness of Negative Pressure Wound Therapy in Patients With Challenging Wounds: A Systematic Review and Meta-analysis - Hmpgloballearningnetwork.com
Article by Mohamed S.A. Shehata, Eshak Bahbah, Yousef El-Ayman, Ahmed H. Abdelkarim, Ahmed R. Abdalla, Ahmed Morshedy, Khaled Turkmani, Ishith Seth and Nimish Seth (Wounds).
NPWT is seemingly associated with better wound healing outcomes compared with conventional therapy. However, the data should be interpreted with substantial caution given limitations such as high heterogeneity between studies and the small sample size of the included studies.
Re-Epithelialization of Neuropathic Diabetic Foot Wounds with the Use of Cryopreserved Allografts of Human Epidermal Keratinocyte Cultures (Epifast) - Wiley.com
Article by Fermin R. Martinez-De Jesús, Robert Frykberg, Elízabeth Zambrano-Loaiza and Edward B. Jude (Mexico, USA, UK - JCM).
Diabetic foot ulcers treated with Epifast displayed a shorter time to complete re-epithelialization than wounds treated with standard care.
Patient experiences of, and preferences for, surgical wound care education - Wiley.com
Article by Georgia Tobiano, Rachel M. Walker, Wendy Chaboyer, Joan Carlini, Louise Webber, Sharon Latimer, Evelyn Kang, Anne M. Eskes, Tom O'Connor, Debra Perger and Brigid M. Gillespie (International Wound Journal).
The authors' results uncovered patient preferences, which could be used to optimise discharge education practices. Embedding patient participation into clinical workflows may enhance patients' self-management practices once home.
Managing Exudate Pooling: A Simplified Practical Guide - PubMed
Abstract by Emily Greenstein, Maarten Vooijs and Sarah Norton (USA - Wound Manag Prev.).
Research trends on platelet-rich plasma in the treatment of wounds during 2002–2021: A 20-year bibliometric analysis - Wiley.com
Article by Honghao Lai, Guangping Chen, Wei Zhang, Guosheng Wu and Zhaofan Xia (China - International Wound Journal).
The mechanism of growth factors of PRP, combination therapy, preparation of PRP, and related clinical trials may be topics that need attention.
Wound Healing as an Unconventional Marker for Epilepsy Control in a Patient Experiencing Homelessness: A Case Report - Nih.gov
Article by Jesse Obregon, Lauren DeLamielleure, Taha F Rasul, Brittany Blake and Armen Henderson (USA - Cureus).
This case demonstrates a method for surveilling epileptic symptoms and medication compliance in the context of limited resources. Wounds sustained during seizure-related accidents can demonstrate disease severity and instability.
Acetic Acid and Wound Healing - Dermatologytimes.com
Article by Ilya Petrou.
A recent study highlighted the therapeutic benefit of acetic acid in a mosaic of dermatologic diseases and conditions, underscoring the need for clinicians to perhaps rethink their topical treatment strategies and protocols, particularly in those patients who are seeking more natural alternative medicine treatment options.
This age-old remedy has long been employed in wound care and wound healing protocols due to the therapeutic success achieved from its antimicrobial and antioxidant properties.
A longitudinal analysis of resting energy expenditure and body composition in people with spinal cord injury undergoing surgical repair of pressure injuries: a pilot study - Nature.com
Article by Amy N. Nevin, Susan Urquhart, Sridhar S. Atresh, Timothy J. Geraghty, Elizabeth Walter, Elizabeth G. Ryan, Angela Vivanti, Leigh C. Ward and Ingrid J. Hickman (Brisbane, Australia - European Journal of Clinical Nutrition).
The presence of pressure injuries and subsequent surgical repair did not impact resting energy expenditure (REE) and energy prediction equations incorporating fat-free mass (FFM) performed best. While not statistically significant, clinically important differences in body composition were observed in those with wound breakdown.
The Treatment Algorithm in Diabetic Foot: An Alternative Against Amputation? - Emjreviews.com
Article by Tacettin Güçer (Kars, Turkey).
The author's clinical treatment modality was found extremely effective by application, according to the algorithm explained in this article, and should be an alternative to the current therapy applications in diabetic ulcers.
Burnout in Wound Care: Caring for Every Care Provider - Woundsource.com
Jobs in the field of medicine are notoriously demanding. However, many factors are converging to exacerbate this problem, and clinician burnout poses a large threat to the health care system in the United States. Unfortunately, this problem does not impact a single segment of specialists but is systemic at many health care facilities.
STRIDE: Do You Know the Essentials of Compression Therapy Device Selection? - Woundsource.com
Article by Suzie Ehmann.
STRIDE, which stands for shape, texture, refill, issues, dosage, and etiology, provides a comprehensive guide for selecting compression garments and wraps. It is a resource for new clinicians and an excellent review for advanced practitioners.
Topical Oxygen Therapy: What Wound Care Professionals Should Know - Woundsource.com
In this interview, Dr. Windy Cole discusses the use of topical oxygen therapies and what processes oxygen help facilitate in wound healing. She indicates the etiologies this therapy can treat as well as care settings that may find the therapy effective.
Management patterns and outcomes of patients hospitalized with diabetic foot ulcers at one tertiary care hospital - PubMed
Abstract by Ajay Bhasin, Karen Marie Krueger, Janna Williams, Reeti Gulati, Nathan Sisler and Shannon Galvin (Chicago, USA - Intern Emerg Med.).
The Use of Metallic Nanoparticles in Wound Healing: New Perspectives - Mdpi.com
Article by Carolini Mendes, Anand Thirupathi, Maria E. A. B. Corrêa, Yaodong Gu and Paulo C. L. Silveira (China, Brazil - IJMS).
This manuscript aims to demonstrate that the application of metallic nanoparticles (gold, silver, copper, and zinc oxide) opened a new chapter in the treatment of wounds, as they have different properties such as drug delivery, antimicrobial activity, and healing acceleration.
Recent Advances in Nanozymes for Bacteria-Infected Wound Therapy - Dovepress.com
Article by Fayin Mo, Minjun Zhang, Xuewei Duan, Chuyan Lin, Duanping Sun and Tianhui You (Guangzhou, China - International Journal of Nanomedicine).
The authors first discuss the pathophysiology of bacteria infected wound healing, the formation of bacterial infection wounds, and the strategies for treating bacterially infected wounds. In addition, the antibacterial advantages and mechanism of nanozymes for bacteria-infected wounds are also described.
Using Natural Extracts to Promote the Antibacterial and Anti-inflammatory Performance of Polyurethane Foams - Springer.com
Article by Sonthaya Chaiarwut, Chasuda Choipang, Pakakrong Sangsanoh, Jitti Niyompanich and Pitt Supaphol (Bangkok, Thailand - Journal of Polymers and the Environment).
In this study, mangosteen extract, which has antibacterial properties, was combined with curcumin extract, which has anti-inflammatory and antioxidant properties, to emphasize the importance of Thai herbs as the driving force of the Thailand economy.
Enhancing Cutaneous Wound Healing Based on Human Induced Neural Stem Cell-derived Exosomes - Dovepress.com
Article by Jing Li, Hong Gao, Yue Xiong, Ling Wang, Haojie Zhang, Fumei He, Jingxin Zhao, Shuna Liu, Liqian Gao, Ying Guo and Wenbin Deng (Shenzhen, China - International Journal of Nanomedicine).
Neural stem cell-exo may enhance wound healing via neurotrophic factors and immunomodulation.
Mesenchymal Stem Cells in Burn Wound Management - Mdpi.com
Article by Agnieszka Surowiecka, Anna Chrapusta, Maria Klimeczek-Chrapusta, Tomasz Korzeniowski, Justyna Drukała and Jerzy Strużyna (Poland - IJMS).
Due to the heterogeneity of the evidence, cellular therapy in burn wound treatment remains an experimental method.
Wound irrigation versus swabbing technique for cleansing noninfected chronic wounds: A systematic review of differences in bleeding, pain, infection, exudate, and necrotic tissue - PubMed
Abstract by Erin M Rajhathy, Juliann Vander Meer, Teresa Valenzano, Leanna E Laing, Kevin Y Woo, Dimitri Beeckman and Karin Falk-Brynhildsen (Sweden, Canada, Belgium - J Tissue Viability).
Wounds under diabetic milieu: The role of immune cellar components and signaling pathways - PubMed
Abstract by Siyuan Lin, Qixue Wang, Xiaoting Huang, Jiawei Feng, Yuqing Wang, Tengteng Shao, Xiaofei Deng, Yemin Cao, Xinghua Chen, Mingmei Zhou and Cheng Zhao (Shanghai, China - Biomed Pharmacother.).
Thermal changes in the sacral region with different mattresses used in the prevention of pressure injuries - PubMed
Abstract by Daniela Akemi Itakura, Adriane Muller Nakato, Paula Karina Hembecker, Eduardo Borba Neves and Percy Nohama (Brazil - J Therm Biol.).
Effects of vildagliptin on wound healing and markers of inflammation in patients with type 2 diabetic foot ulcer: a prospective, randomized, double-blind, placebo-controlled, single-center study - PubMed
Abstract by Venkat N Vangaveti, Shaurya Jhamb, Oliver Hayes, Julie Goodall, Jacqueline Bulbrook, Kelvin Robertson, Erik Biros, Kunwarjit S Sangla and Usman H Malabu (Australia - Diabetol Metab Syndr.).
The effect of topical olive oil dressing on the healing of grade 1 and 2 diabetic foot ulcers: An assessor-blind randomized controlled trial in type 2 diabetes patients - PubMed
Abstract by Aminreza Abdoli, Roghayeh Shahbazi, Ghazal Zoghi, Parivash Davoodian, Somayeh Kheirandish, Mohsen Azad and Masoumeh Kheirandish (Iran, Canada - Diabetes Metab Syndr.).
Diabetes and Foot Infection: What Is the Relationship - Verywellhealth.com
Article by Barbie Cervoni.
Over time type 2 diabetes can affect all body parts, including the feet. When blood sugars are not controlled, moist areas in the feet are prone to infections. People with diabetes can experience nerve damage, lack of sensation, and difficulty with wound healing if their blood sugars are chronically elevated (hyperglycemia). This can increase the risk of ulcers or sores, which can become infected if not detected and treated promptly.
Wound Repair Using Discarded Skin Tissue From the Rolled Edge of Pressure Injury: A Feasibility Study of Five Cases - Hmpgloballearningnetwork.com
Article by Zhi'yuan Shi, Min'hui Zhu, Ming Zhang and Xiang'bo Ye (Wounds).
The split skin particles harvested from the rolled edge of the wound consisted of keratinocytes and keratinized tissues and were found to be viable and proliferative. These particles had the capacity to survive and expand on the granulation tissue surface of PIs, which indicates this procedure could accelerate reepithelization in chronic wounds.
Intact Fish Skin Graft vs. Standard of Care in Patients with Neuroischaemic Diabetic Foot Ulcers (KereFish Study): An International, Multicentre, Double-Blind, Randomised, Controlled Trial Study Design and Rationale - Mdpi.com
Article by Dured Dardari, Louis Potier, Ariane Sultan, Maude Francois and Jocelyne M’Bemba et. al. (France - Medicina).
The aim of the KereFish and larger Odin study is to demonstrate the superiority of Kerecis Omega3 Wound over SOC in the treatment of diabetic wounds.
Factors affecting the incidence and prevalence of pressure ulcers in COVID‐19 patients admitted with a Braden scale below 14 in the intensive care unit: Retrospective cohort study - Nih.gov
Article by Mahin Amini, Feizollah Mansouri, Kamran Vafaee, Alireza Janbakhsh, Somayeh Mahdavikian, Yasaman Moradi and Masoud Fallahi (Kermanshah, Iran - Int. Wound J.).
The widespread prevalence of COVID‐19 and the relatively long stay of patients in the ICU created unfavourable conditions for patients and the treatment system, therefore, it emphasised the use of appropriate measures to prevent pressure ulcer to avoid double costs and longer stays.
Conservative treatment of non-healing plantar skin ulcer complicated by infection and fistula in congenital clubfoot. A case report - PubMed
Abstract by Luca Palombi, Monica Morelli and Maurizio Palombi (Italy - Ann Ital Chir.).
Pressure Injury Prevention: What Areas Are at Risk? - Woundsource.com
Pressure injuries are an unfortunate and all too frequent occurrence, despite being preventable. It is estimated that approximately 2.5 million hospitalizations in the United States are due to pressure injuries. According to research by the NPIAP, up to 40% of patients will develop a pressure injury while in critical care units. However, a clinician can assist in preventing these pressure injuries by understanding which anatomic areas are most at risk.
Lacerations: Does closure technique matter? - First10em.com
Article by Justin Morgenstern.
There are a lot of strong opinions about how lacerations should be repaired. There may be even more laceration repair techniques. This seems like a good spot for a ‘more than one way to skin a cat’ joke, but what we really want is evidence. Which laceration repair technique is the best, according to science?
Oncology wounds - recommendations for care based on multidisciplinary cooperation - PubMed
Abstract by S Vokurka, A Pokorná, J Stryja, L Krupová, V Mezera, J Cvek, P Holečková, R Ston, L Hašková, M Audyová, Z Pechačová, S Šípová, K Jirsová and L Veverková (Klin Onkol.).
Effectiveness of Telemedicine for the Management of Foot Ulcers in People With Diabetes: A Meta-Analysis - PubMed
Abstract by Ushna Khan, Khubaib Ahmad, Sai Sreya Yadlapalli, Muhammad Haseeb, Burha Kabir, Deepa Khemani, Palwasha Ghulam Moosa and Samiullah Khan (Pakistan, Cureus).
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