Bioactive Dressing: A New Algorithm in Wound Healing - Mdpi.com
Article by Gianmarco Polverino, Francesca Russo and Francesco D’Andrea (Naples, Italy - JCM).
To facilitate dressing selection, a practical algorithm considers wound exudate, infection probability, and bleeding, guiding clinicians through the process. This algorithm aims to optimize wound care by ensuring the appropriate selection of bioactive dressings tailored to individual patient needs, ultimately improving outcomes in wound management.
Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing - Nature.com
Article by Xiaoxue Han, Chaimongkol Saengow, Leah Ju, Wen Ren, Randy H. Ewoldt and Joseph Irudayaraj (Urbana, USA - Nature Communications).
The authors show the potential of this multifunctional hydrogel for enhanced healing, promoting angiogenesis, facilitating exosome delivery, mitigating hypoxia, and inhibiting inflammation in a male rat full-thickness wound model.
Host–Microbiome Crosstalk in Chronic Wound Healing - Mdpi.com
Article by Mara Mădălina Mihai, Beatrice Bălăceanu-Gurău, Ana Ion, Alina Maria Holban et al. (Bucharest, Romania - IJMS).
In this review article, the authors aim to summarize the current progress achieved in host–microbiome crosstalk in the spectrum of CW healing and highlight future innovative strategies to boost the host immune response against infections, focusing on the interaction between pathogens and their hosts (for instance, by harnessing microorganisms like probiotics), which may serve as the prospective advancement of vaccines and treatments against infections.
Granulox® (topical haemoglobin spray) in the management of hard-to-heal wounds: Clinical experiences from around the world - Woundsinternational.com
Article by Phil Davies.
The clinical and health economic evidence suggests that Granulox® (as an adjunct to standard care) supports the achievement of better clinical outcomes at a reduced cost, thereby providing a dominant treatment option when compared to standard care alone.
Multidrug-Resistant Pathogens in Wound Infections: A Systematic Review - Woundsinternational.com
Article by Faheem Ilyas, Aimen James, Shahid Khan, Soban Haider et al. (Pakistan).
This systematic review aimed to explore the antimicrobial activity of a silver-containing gelling fiber dressing against multidrug-resistant organisms (MDROs) in wound infections. It particularly focuses on burn wounds and evaluates its potential clinical significance in combating antimicrobial resistance.
Wound Healing: Cellular Review With Specific Attention to Postamputation Care - PubMed
Abstract by David S Kirwin, Harrison E Diaz, Travis C Frantz, Cory F Janney et al. (San Diego, USA - Cutis).
Effect of negative pressure therapy on the treatment response to scar thickness and viscoelasticity - Frontiersin.org
Article by Wei-Cheng Shen, Hsu-Tang Cheng, Yih-Kuen Jan, Ben-Yi Liau et al. (Taiwan, USA - Front. Bioeng. Biotechnol.).
This study investigates the magnitude of effective negative pressure in scar treatment. Scar thickness is most effectively reduced with −105 mmHg, and scar viscoelasticity is most steadily increased with −125 mmHg in clinical negative pressure therapy.
Platelet-Rich Plasma - a remedy present in every human being. History, functioning, and the benefits of therapy using it - PubMed
Abstract by Monika Prokurat, Katarzyna Grudnik, Wojciech Niemczyk, Stanisław Niemczyk et al. (Poland, Pol Merkur Lekarski).
A realist evaluation of devices used for the prevention of heel pressure ulcers: An ethnographic study of clinical practice - PubMed
Abstract by Clare Greenwood, Jane Nixon, E Andrea Nelson, Elizabeth McGinnis and Rebecca Randell (UK - Appl Nurs Res.).
Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis - Sciencedirect.com
Article by Hai Bang Pan, Yan Cui, Zhi Hang Wu, Ying Meng et al. (China - Advances in Skin & Wound Care).
The authors' findings indicate that local antibiotics combined with conventional antibiotics in the wound before wound closure are effective in reducing the incidence of SSI in clean surgical wounds. Vancomycin inoculation of the graft exhibited the best effect.
Low intensity negative electric current in the treatment of ulcers of the leg due to chronic venous insufficiency: Preliminary report of three cases - Sciencedirect.com
Abstract by Dennis Assimacopoulos (Athens, Greece - The American Journal of Surgery).
The effect of pressure injury prevention care bundles on pressure injuries in hospital patients: A complex intervention systematic review and meta-analysis - PubMed
Abstract by Wendy Chaboyer, Sharon Latimer, Udeshika Priyadarshani, Emma Harbeck et al. (Australia, Sri Lanka - Int J Nurs Stud.).
Study: The Role of Vitamin A in Wound Repair - Pharmacytimes.com
Article by Kennedy Ferruggia.
Researchers from Rockefeller University found that retinoic acid, the biologically active form of Vitamin A is linked with the process of lineage plasticity— a cell’s ability to switch and change its phenotype identity. This can be displayed when skin stem cells grow epidermis to cover a wound or hair follicle stem cells morph into epidermal stem cells to repair destruction, according to study authors. However, research has provided that the function cannot be done effectively until they choose a decisive state.
Uterine Cesarean Scar Tissue – An Immunohistochemical Study - Mdpi.com
Article by Maciej Ziętek, Małgorzata Świątkowska-Feund, Sylwester Ciećwież, Tomasz Machałowski and Małgorzata Szczuko (Poland - Medicina).
The authors findings indicate that there are no significant alterations in the biomechanical properties of the uterine muscle beyond a period of 13 months following a cesarean section.
Silver nanoparticle dressing: The knowledge of advantages and limits improves the indications in clinical practice - Nih.gov
Article by Valentina Budini, Franco Bassetto, Carlotta Scarpa and Vincenzo Vindigni (Padova, Italy - Int Wound J.).
Ag‐NPS dressing is a promising way of promoting the development of a fertile wound bed and healing moderate‐length chronic wounds. Silver nanoparticles lead to progressive cleaning of the ulcer, reduction of signs of local infection and improvement of the perilesional skin.
Why is my wound taking so long to heal? - Medicalnewstoday.com
There are various reasons why wounds might take longer to heal. In this article, the authors look at some of the reasons and what to do if a wound is taking a long time to heal.
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? - Biomedcentral.com
Article by Lioba Huelsboemer, Leonard Knoedler, Alejandro Kochen, Catherine T. Yu et al. (New Haven, USA - Military Medical Research).
This review provides a comprehensive exploration of current therapies, experimental approaches, and translational studies, offering insights into their efficacy and limitations.
Effect of platelet-rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta-analysis - Wiley.com
Article by Hao Chen, Tong-Jie Xu, Hao Yu, Jun-Long Zhu, Yong Liu and Lu-Pin Yang (Luzhou, China - International Wound Journal).
This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.
Analysis of risk factors affecting wound healing and wound infection after meningioma resection - Wiley.com
Article by Jianye Wang, Jixin Shou, Haidong Gao, Bingbing Wang et al. (Zhengzhou, China - International Wound Journal).
The influence of each factor is different. Age, smoking history, WHO Meningioma Grading, preoperative albumin, preoperative platelets, history of virus infection and history of neurological disorders had the greatest influence on wound healing and infection after meningioma resection.
Diabetic Foot Ulcers: Life-Threatening Issue in Need of Help - Medscape.com
Article by Kathleen Doheny.
Worldwide, about 18.6 million people have a DFU each year, including 1.6 million in the United States. About 50%-60% of ulcers become infected, with 20% of moderate to severe infections requiring amputation of the limb. The 5-year mortality rate for DFUs is 30%, but it climbs to 70% after amputation. While about 40% of ulcers heal within 12 weeks, 42% recur at the 1-year mark, setting up a vicious and costly cycle. Healthcare costs for patients with diabetes and DFUs are five times as high as costs for patients with diabetes but no DFUs. The per capita cost to treat a DFU in America is $17,500.
Lipase and Protease Production Ability of Multi-drug Resistant Bacteria Worsens the Outcomes of Wound Infections - PubMed
Abstract by Attaur Rahman, Saiqa Sardar, Zeeshan Niaz, Asif Khan et al. (Brazil, Saudi Arabia, Pakistan, South Korea - Curr Pharm Des.).
Efficacy of Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Wounds: A Retrospective Observational Study - PubMed
Abstract by Abdulkadir Calavul (Sanliurfa, Turkey - Int J Low Extrem Wounds).
Hidradenitis suppurativa: How Wound Care Professionals Can Help Patients - Woundsource.com
In this interview, Hadar Lev-Tov discusses how wound care professionals can approach the management of patients with Hidradenitis suppurativa. At WoundCon Spring 2024, he presented, Hidradenitis Suppurativa and Wounds: Exploring the Unexplored.
Pressure Injury and Microclimate: How Linen Layers May Contribute - Woundsource.com
Article by Laura Swoboda.
Pressure injuries (PI) and their effect on patients across settings are a growing concern for wound care professionals. Strategies to prevent and manage these injuries are constantly explored by leaders in the field, with special attention to linens and dressings.
A new dressing system for accelerating wound recovery after primary total knee arthroplasty: a feasibility study - Biomedcentral.com
Article by Pengfei Lei, Fawei Gao, Jun Qi, Zhigang Li et al. (China - BMC Surgery).
In this study, the authors invented a new dressing system for surgical wounds after total knee arthroplasty and further confirmed its clinical feasibility and safety.
Management of Acute Wounds - Expert Panel Consensus Statement - PubMed
Abstract by Oluyinka O Olutoye, Elof Eriksson, Alicia D Menchaca, Robert S Kirsner et al. (USA, Japan - Adv Wound Care (New Rochelle)).
The Crucial Role of pH in Healing Diabetic Foot Ulcers: - Diabeticfootonline.com
The observational study by Yiru Wang and colleagues provides valuable insights into the role of pH in the healing process of diabetic foot ulcers. By incorporating dynamic pH monitoring into the management of these ulcers, healthcare professionals can enhance the effectiveness of interventions and improve patient outcomes. As the global burden of diabetic foot ulcers continues to rise, such research is crucial in advancing our understanding and treatment of this challenging condition.
Potential of Curcumin in the Management of Skin Diseasesg - PubMed
Abstract by Kamila Kasprzak-Drozd, Przemysław Niziński, Anna Hawrył, Marek Gancarz et al. (Poland - Int J Mol Sci.).
A Systematic Review of the Design and Applications of Antimicrobial Peptides in Wound Healing - Cureus.com
Article by Aqeel Ahmad, Javed M. Khan and Altaf Bandy (Saudi Arabia).
Antimicrobial peptides in wound healing display a diverse mechanism of action, influencing the inflammatory response, encouraging tissue regeneration, and aiding tissue remodeling, along with strong antibacterial activity.
Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin? - Mdpi.com
Article by Magdalena Stachowiak, Dariusz T. Mlynarczyk and Jolanta Dlugaszewska (Poznan, Poland - Molecules).
Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.
Five Compelling Reasons Why Shock Wave Therapy Machines Are Transforming Wound Care - Shockwavecanada.com
When it comes to wound care, innovation can make the difference between healing and prolonged suffering. Shockwave therapy provides a ground-breaking alternative to wound management that can transform patient and physician expectations and deliver results more efficiently and quickly. How does this happen?
Hidradenitis suppurativa: What Is It? - Woundsource.com
In this interview, Hadar Lev-Tov discusses what Hidradenitis suppurativa is and relevant questions in relation to his WoundCon Spring 2024 session titled, Hidradenitis Suppurativa and Wounds: Exploring the Unexplored.
Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds - Mdpi.com
Article by Lidia Maeso, Pablo Edmundo Antezana, Ailen Gala Hvozda Arana, Pablo Andrés Evelson et al. (Spain, Argentina - Pharmaceutics).
In this review, the authors highlight the latest advances in the use of natural polymers with antioxidants to generate tissue regeneration microenvironments for skin wound healing.
Entero-Cutaneous and Entero-Atmospheric Fistulas: Insights into Management Using Negative Pressure Wound Therapy - PubMed
Abstract by Gilda Pepe, Maria Michela Chiarello, Valentina Bianchi, Valeria Fico et al. (Italy - J Clin Med.).
High Pressure 3 × 30 Minute Compression Methods for Advanced Lower Limb Lymphedema Patients - PubMed
Abstract by Marzanna T Zaleska and Natalia E Krzesniak (Warsaw, Poland - Lymphat Res Biol.).
Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age - Mdpi.com
Article by Nicola Fullard, James Wordsworth, Ciaran Welsh, Victoria Maltman et al. (UK, USA - Cells).
The authors concluded that the increased collagen degradation of aged fibroblasts might reflect senescence, the reduced collagen production likely reflects senescence-independent processes.
The Importance of Adequate Debridement - Generalsurgerynews.com
Article by Jarrod P. Kaufman.
Debridement is a time-honored method that still has immense value for patients with acute and chronic wounds. When performed correctly and with appropriate frequency, debridement clearly leads to increased healing rates and closure in most types of wounds. Care needs to be taken, however, to clearly define the type of wound being cared for to ensure that the appropriate adjunctive methods are used in special wounds like venous ulcers or pyoderma gangrenosum.
The frictional energy absorber effectiveness and its impact on the pressure ulcer prevention performance of multilayer dressings - PubMed
Abstract by Cécile Marché, Sue Creehan and Amit Gefen (Israel, USA, Belgium - Int Wound J.).
Wound warriors: How microbes influence healing and infection risks - News-medical.net
Article by Sanchari Sinha Dutta.
In a recent Nature Reviews Microbiology study, researchers review how the wound microbiota interferes with skin repair processes and facilitates infection onset by modulating host immune responses.
An innovative flat-knit compression garment for lymphoedema patients led to better outcomes: a multicentre study - Magonlinelibrary.com
Article by Tobias Hirsch, Helene Arns, Jörg Schleinitz and Hans-Walter Fiedler (Germany - J Wound Care).
In this study, the tested innovative compression product increased patient satisfaction with the improved product features while the lymphoedema status was successfully maintained.
Sub-ulcer Foam Sclerotherapy in Patients with Venous Leg Ulcer, Analysis and Technical Aspects of 134 Consecutive Patients - Magonlinelibrary.com
Abstract by Toni Pihlaja, Emmi Kosunen, Pasi Ohtonen and Matti Pokela (Oulu, Finland - Int J Low Extrem Wounds).
Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome - Nature.com
Article by Layla Mathieson, Lilian Koppensteiner, David A. Dorward, Richard A. O’Connor and Ahsan R. Akram (Edinburgh, UK - British Journal of Cancer).
This study describes the fibroblast heterogeneity in non-small cell lung cancer and the prognostic importance of the novel CAF-S5 subset where its presence correlates to worse survival outcome.
The assessment and management of foot and toe oedema as part of holistic lower limb care - PubMed
Abstract by Jeanne Everett, Sue Lawrance, Karen Cooper and Natalie Phillips (Haddenham, UK - Br J Community Nurs).
Infection induced inflammation impairs wound healing through IL-1β signaling - PubMed
Abstract by Simone Shen, Veronika Miskolci, Colin N Dewey, John-Demian Sauer and Anna Huttenlocher (Madison, USA - iScience).
Evaluating the efficacy of standardized pressure ulcer management protocols in the prevention of pressure injuries among patients undergoing neurosurgical procedures - Wiley.com
Article by Jing Zhang, Wenxia Li, Yanyan Li, Man Ma and Kun Shang (Zhengzhou, China - International Wound Journal).
The authors' findings highlight the importance of adopting structured care protocols to improve postoperative outcomes and patient well-being in neurosurgical settings.
Effect of probiotics and synbiotics on complications of wound infection after colorectal surgery: A meta-analysis - Wiley.com
Article by Junqiu Jiang and Feng Ren (Dalian, China - International Wound Journal).
This meta-analysis showed that probiotics and synbiotics can significantly reduce post-colorectal wound infection and benefit patients' postoperative recovery.
The cellular players that enable wound healing - Drugdiscoverynews.com
Article by Luisa Torres.
A coordinated effort between the stroma, the immune system, and the skin microbiome restores damaged skin.
The wound microbiota: microbial mechanisms of impaired wound healing and infection - Nature.com
Abstract by Aayushi Uberoi, Amelia McCready-Vangi and Elizabeth A. Grice (Philadelphia, USA - Nature Reviews Microbiology).
Medicinal plants with potential wound healing activity: a review article - Medcraveonline.com
Article by Tinku Kumar, Girendra Kumar Gautam, Rohit Malik and Jagpal Singh (Muzaffarnagar, India - MedCrave).
This review highlights all the plants which are traditionally and scientifically proven for the used in treated of wounds and wound care. It also covers the list of the plants and its part of plant used traditionally and scientifically for wound care.
Effect of quality nursing care on wound pain and anxiety in burn patients: A meta-analysis - Wiley.com
Article by Ling Yang, Bo-Qin Yuan, Yang-Yang Ju, Wei Liu and Yang-Ping Wang (Chongqing, China - International Wound Journal).
It was found that, compared with routine care, burn patients who implemented quality care had significantly less wound pain, anxiety and depression levels were significantly reduced post-trauma.
Role of the Skin Immune System in Wound Healing - Mdpi.com
Article by Angela Cioce, Andrea Cavani, Caterina Cattani and Fernanda Scopelliti (Rome, Italy - Cells).
This review aims to summarize the roles of different immune cells, with special emphasis on the different stages of the wound healing process.
The Chicken Egg: An Advanced Material for Tissue Engineering - Mdpi.com
Article by Yuli Zhang, Hieu M. Pham and Simon D. Tran (Canada, USA - Molecules).
This review will provide researchers with a concise yet comprehensive understanding of the chicken egg structure, composition, and associated bioactive molecules in each component and introduce up-to-date tissue engineering applications of chicken eggs as biomaterials.
Efficacy of Biomechanics-based Decompression Therapy in Managing Recurrent Diabetic Plantar Ulcers - PubMed
Abstract by Yan Wan, Zheng Wang, Jiao-Jiao Bai, Yun-Min Cai et al. (Shanghai, China - Int J Low Extrem Wounds).
Cold Atmospheric Plasma Is a Promising Alternative Treatment Option in Case of Split Skin Graft Failure - Hindawi.com
Article by Aydar Khabipov, Andre Schreiber, Stephan Kersting, Richard Hummel et al. (Germany - Case Reports in Surgery)
This report highlights the wound healing-promoting effects of CAP and discusses its potential mechanisms of action.
Nanotechnological Research for Regenerative Medicine: The Role of Hyaluronic Acid - Mdpi.com
Article by Flavia Carton and Manuela Malatesta (Verona, Italy - IJMS).
This review offers an overview of the various uses of HA in regenerative medicine aimed at designing innovative nanostructured devices to be applied in various fields such as orthopedics, dermatology, and neurology.
Talking to Patients About Antimicrobial Resistance - Woundsource.com
In this interview, Alisha Oropallo discusses why and how wound care clinicians can talk to patients about antimicrobial resistance and stewardship practices.
Debridement of Burns – Navigating a Challenging Population - Woundsource.com
Did you know eschar may present differently in burn wounds as opposed to wounds of other etiologies? In this interview, Dr. Maria Goddard describes how the debridement of burn wounds is distinct from that of other wound types.
Sharp Debridement Tips and Pearls - Woundsource.com
How should clinicians approach pain modulation when implementing sharp debridement? In this interview, Dr. John Lantis reviews the best practices he uses regarding dressing selection, pain management, and acquisition of essential patient history components.
Can a prolonged healing pressure injury be benefited by using an AI mattress? A case study - Biomedcentral.com
Article by Tung Fang Ni, Jyh-Liang Wang, Chih-Kuang Chen, De Fen Shih and Jeng Wang (Taiwan - BMC Geriatrics).
This novice device appeared to accelerate wound healing in this case. In the future, more cases should be tested, and different care models or mattress can be explored.
Pseudomonas Wound Infection: What Is It and What Are the Signs? - Woundsource.com
Article by Emily Greenstein.
Pseudomonas aeruginosa (PA) is a common gram-negative aerobic bacilli bacterial infection in chronic wounds. PA is often present in soil, water, humans, and on the surface of medical devices, plants, and animals. PA is an opportunistic infection that can cause serious disease. Patients with an immunocompromised state will often have PA infections.
MRSA: The Basics - Woundsource.com
Article by Cathy L. Harmon.
Staphylococcus aureus, or "staph" bacteria, normally reside on the skin and nose and are usually harmless. Most individuals do not manifest any symptoms of illness; however, due to its prevalence, this pathogen is a common culprit of hospital-acquired infection.
Do You Know The Basics of Incontinence-Associated Dermatitis Treatment and Prevention? - Woundsource.com
Article by Elizabeth Day Dechant.
Incontinence-associated dermatitis (IAD) affects hospitalized and incontinent patients of all ages. This article focuses on the prevention and treatment of diaper rashes in infants and young children, although the principles of topical treatment discussed here apply to all patients.
Moisture-Associated Skin Damage and Incontinence-Associated Dermatitis: Etiology, Diagnosis, and Management Strategies - Woundsource.com
Article by Dimitri Beeckman.
Moisture-associated skin damage (MASD) and related conditions affect many patients, especially older adults with incontinence, each year. Professor Dimitri Beeckman, explains MASD and its related conditions, identification, prevention, and management.
Plants as a cost-effective source for customizable photosynthetic wound dressings: A proof of concept study - Wiley.com
Abstract by Sergio González-Itier, Miguel Miranda, Rocío Corrales-Orovio, Constanza Vera et al. (Chile, Germany - Biotechnology and Bioengineering).
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