Hungarian Wound Care Society

Microenvironment-responsive, multimodulated herbal polysaccharide hydrogel for diabetic foot ulcer healing - Nature.com
Article by Xingcan Chen, Zhengbo Hu, Kai Zhao, Xin Rao et al. (Hangzhou, China - Scientific Reports). The developed BSP/BER hydrogel in this study could be the potential dressing for clinical treatment of DU wound.

Oxygen and healing - Sciencedirect.com
Abstract by Thomas K. Hunt, Bengt Zederfeldt and Thomas K. Goldstick (San Francisco, USA - The American Journal of Surgery).

Photobiomodulation as Medicine: Low-Level Laser Therapy (LLLT) for Acute Tissue Injury or Sport Performance Recovery - Mdpi.com
Article by Julia Lawrence and Karin Sorra (Toronto, Canada - JFMK). Variability in LLLT delivery parameters and findings across studies underscores a need for clear treatment guidelines for the profession. Technical properties of laser light delivery to the body also differ materially from LED devices.

Skin Adhesive Tapes: An Effective Wound Closure Method for Percutaneous Vertebral Body Stenting - Cureus.com
Article by Cassie Yang, Theophilus Qiu, Reuben Soh Chee Cheong and Youheng Ou Yang (Singapore). Skin adhesive tapes are a safe and reliable means of wound closure for vertebral body stenting. Conversion to suture closure due to continued intraoperative wound site bleeding is rarely required.

MDRPI in the Operating Room: What Do We Currently Know? - Woundsource.com
An August 2024 study provided a scoping review of medical device-related pressure injuries (MDRPI) during surgical procedures. They reviewed literature from 2014 and later, both in English and Chinese languages. This included 14 research studies and 2 studies on quality improvement.

Intervening with Urgency: A New Tool for Early Recognition of Chronic and Non-Healing Wounds - Woundsource.com
In this interview with Dr. Trent Brookshier, learn more about an emerging tool to help guide wound intervention.

Innovations in Wound Dressings: What is the Impact on Patients? - Woundsource.com
How does innovation in dressings impact wound care? This interview with Catherine T. Milne highlights key concepts to consider for your practice.

Surgical wound complications update - Wounds-uk.com
Article by Jacky Edwards. Raising awareness of surgical wound complications and understanding the scale of the problem are imperative. Therefore, it is essential to develop a surveillance system for community and primary care, embed education and empower patients to be actively involved in their care.

Leg ulcer management: enabling evidence-based practice - Wounds-uk.com
Article by Leanne Atkin, Hollie Robinson and Kelly Phillips. Access to evidence-based care is key to improving healing rates. Leaders of wound care services need to ensure there are EBP clinical pathways in place and that clinicians have easy access to evidence-based products. Ultimately it is the responsibility of the formulary owners to adopt evidence into practice, they need to be able to justify their decisions and be held accountable for how they spend public money.

The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing - Dovepress.com
Article by Xiangan Gong, Qian Zhao, Huimin Zhang, Rui Liu et al. (China - International Journal of Nanomedicine). The authors gave a comprehensive summary of the existing research on three main metabolisms, including glycometabolism, lipid metabolism and amino acid metabolism, and MSC-Exo regulating metabolic reprogramming in wound healing and scar formation for further research reference.

Collagen and Its Derivatives Serving Biomedical Purposes: A Review - Mdpi.com
Article by Hanna Wosicka-Frąckowiak, Kornelia Poniedziałek, Stanisław Woźny, Mateusz Kuprianowicz et al. (Poland - Polymers). The review discusses various collagen-based biomaterials, including solutions, hydrogels, powders, sponges, scaffolds, and thin films. These materials have broad applications in regenerative medicine, tissue engineering, drug delivery, and wound healing.

Application of Closed Incision Negative Pressure Wound Therapy in Ventral Hernia Repair Surgery Using a Polypropylene Mesh: A Randomized Clinical Trial - Mdpi.com
Article by Petr Jelinek, Jan Hrubovcak, Radovan Hajovsky, Jan Velicka and Martin Pies (Czech Republic - Medicina). Although limited by a small sample size, the findings suggest that ciNPWT may be associated with a reduced rate of SSI following ventral hernia repair. Further studies with larger populations are needed to confirm these results.

Granulocyte colony stimulating factor promotes scarless tissue regeneration - Sciencedirect.com
Abstract by Jianhe Huang, Satish Sati, Christina Murphy, Casey A. Spencer et al. (USA, Singapore - Cell Reports).

Harnessing exosomes and hydrogels for advanced diabetic wound healing - Phys.org
In studies using diabetic mouse models, Q5Exo demonstrated a significant reduction in healing time when applied topically compared to exosomes administered via injection. This suggests that protein-based hydrogels, with their tunable properties, could become a powerful platform for enhancing wound healing outcomes in diabetes.

Anti-Inflammatory and Wound Healing Properties of Different Honey Varieties from Romania and Correlations to Their Composition - Mdpi.com
Article by Andreea Iosageanu, Laura Mihaela Stefan, Oana Craciunescu and Anisoara Cimpean (Bucharest, Romania - Life). Honey varieties presented both anti- and pro-inflammatory effects. Moreover, they displayed dose-dependent pro-proliferative effects, stimulating collagen synthesis and cell migration, thereby enhancing the re-epithelialization process.

An antimicrobial microneedle patch promotes functional healing of infected wounds through controlled release of adipose tissue-derived apoptotic vesicles - Biomedcentral.com
Article by Yue Ma, Jia Dong, Maojiao Li, Xinya Du et al. (China - Journal of Nanobiotechnology). ApoEVs-AT@MNP has emerged as an excellent, painless, non-invasive, and highly promising treatment for infected wounds.

Differences in Soft Tissue Wound Healing between Immediate and Delayed Implant Placement: An Experimental Preclinical In Vivo Investigation - Mdpi.com
Article by Rafael Pla, Javier Sanz-Esporrin, David Palombo, Fabio Vignoletti et al. (Madrid, Spain - Applied Sciences). Soft tissue dimensions around immediate implants differ from those established around staged implants placed on healed alveolar ridges.

Exploring the Antibacterial and Regenerative Properties of a Two-Stage Alginate Wound Dressing in a Rat Model of Purulent Wounds - Mdpi.com
Article by Aliya Atepileva, Vyacheslav Ogay, Gulshahar Kudaibergen, Guldarigash Kaukabaeva et al. (Kazakhstan - Biomedicines). The authors' findings suggest that the modified alginate dressings significantly enhance the reparative process and are promising for treating chronic infected wounds in both veterinary and medical practices.

Clinical Evaluation of AMNIODERM+® Wound Dressing Containing Non-Viable Human Amniotic Membrane: Retrospective-Perspective Clinical Trial - Mdpi.com
Article by Iveta Schmiedova, Petr Slama, Alena Dembickaja, Beata Kozova et al. (Czech Republic, Slovakia - BioTech). The findings from the clinical trial “Freeze-dried amniotic membrane in the treatment of nonhealing wounds” suggest AMNIODERM+® as a promising future treatment for chronic diabetic foot ulcers.

Continuous Diffused Oxygen Therapy for Wound Healing - Canjhealthtechnol.ca
CDO therapy appears to be clinically effective for treating patients with diabetic foot ulcers, particularly chronic or hard-to-heal ulcers that have not responded to standard care. Rates of adverse events were comparable between patients receiving CDO and patients receiving standard care. Two cost-effectiveness studies reported that CDO is likely to be cost-effective compared to standard care for patients with chronic, hard-to-heal diabetic foot ulcers.

Computational Designed and Optimized Liposomal Curcumin-Embedded Bifunctional Cross-Linked Hydrogels for Wound Healing - Mdpi.com
Article by Chaiyakarn Pornpitchanarong, Khin Cho Aye, Kwanputtha Arunprasert, Praneet Opanasopit and Prasopchai Patrojanasophon (Thailand - Gels). This study demonstrated the effectiveness of the CUR-L@HA/PVA/PNVP-ITA hydrogel in improving wound healing. The liposomes were optimized using a statistical computer program to achieve a small particle size with a suitable ZP and maximized curcumin content.

Effective treatment of pressure ulcers with the NPWT in spinal cord injured patients - final results of the case series - PubMed
Abstract by Pavel Kůřil, Andrea Menšíková, Marika Svobodová, Alica Hokynková et al. (Brno, Czech Republic - J Wound Care).

Could Extracorporeal Shockwave Therapy be an Appealing Option for Complex Wounds? - Woundsource.com
A recent case series in Wound Management and Prevention looked at the effect of extracorporeal shockwave therapy (ESWT) on complex chronic wounds. The patients had multiple comorbidities and underwent treatment in a medically underserved outpatient setting. Initial data included baseline wound dimensions and photographs. All patients received standard-of-care wound cleansing. Patients receiving ESWT had did so weekly for up to 12 weeks.

Biomarkers in Wound Care: How to Track Outcomes - Woundsource.com
Biomarkers are substances or processes that can indicate both the status of a condition and a patient’s response to treatment. This piece will introduce various biomarkers relevant to wound care, and how they impact the healing process.

Modelling wound area in studies of wound healing interventions - Biomedcentral.com
Article by Samuel I. Watson, Eleni Gkini, Jon Bishop, Katie Scandrett et al. (Birmingham, UK - BMC Medical Research Methodology). Model-based analyses can dramatically improve the precision of estimates but care must be taken to carefully compare and select the best fitting models. The (log) square-root model is strongly recommended reflecting advice from a century ago.

Advanced Approaches in Skin Wound Healing – a Review on the Multifunctional Properties of MXenes in Therapy and Sensing - Rsc.org
Abstract by Valeria Ferrara, Caterina Perfili, Giulia Artemi, Brunella Iacolino et al. (Italy, Ukraine, Latvia, UAE - Nanoscale).

Healing chronic wounds with gold and red wine - Earth.com
Article by Rodielon Putol. Wounds that resist healing have long posed a significant challenge in medical care, but a recent discovery offers a solution that combines luxury with cutting-edge science.

Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats - Mdpi.com
Article by Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Érique Ricardo Alves,Glícia Maria de Oliveira et al. (Recife, Brazil - Polymers). It was concluded that treating the skin lesions of diabetic animals supplemented with melatonin using a bacterial cellulose-based dressing has positive effects in regulating the expression of inflammatory cytokines, vascular endothelial growth factor, and collagen, showing that this association could be a viable therapy approach in wound healing.

Extracorporeal Shockwave Therapy Effective in Treating Diabetic Foot Ulcers, Reports Study - Medicaldialogues.in
Article by Jacinthlyn Sylvia. A recent meta-analysis published in the Diabetes Research and Clinical Practice unveiled the effectiveness of extracorporeal shockwave therapy (ESWT) in treating diabetic foot ulcers (DFUs). The study reviewed randomized controlled trials (RCTs) published before August 8, 2023 and highlighted the potential benefits of ESWT as a therapeutic option for DFUs.

Primary and secondary prevention in lower leg wounds - Wounds-uk.com
Article by Jacqui Fletcher, Leanne Atkin, Gill Boast, Debbie Brown et al. (UK). We know that the numbers of patients affected by lower limb wounds and ulceration are staggeringly high. While care has long reflected the evidence that healing patients quickly is of paramount importance, there is a need for a change of mindset that focuses on prevention rather than management.

In Vitro Wound-Healing Potential of Phenolic and Polysaccharide Extracts of Aloe vera Gel - Mdpi.com
Article by Andreea Iosageanu, Elena Mihai, Ana-Maria Seciu-Grama, Elena Utoiu et al. (Bucharest, Romania - JFB). The authors' findings indicate that the phenolic extract might be more beneficial in formulations intended for the initial phases of wound healing, such as inflammation and proliferation, while the polysaccharide extract could be more suitable for use during the remodeling stage.

Glycemic Control in Diabetic Foot Ulcers: A Comparative Analysis of Wound and Wound-free Periods in Adult Patients with type 1 and type 2 diabetes mellitus - PubMed
Abstract by Salman Z Bhat, Noora Al-Hajri, Sarah Kanbour, Muzzammil Ahmadzada et al. (Baltimore, USA - Can J Diabetes.)

Pyroptosis found to promote wound healing and tissue repair - News-medical.net
A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair. This research, published in Nature, opens new avenues for understanding how our bodies respond to injury and could lead to innovative treatments for wounds and inflammatory diseases.

Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms - Sciencedirect.com
Abstract by Wenqi Wang, Peng Gao, Hengshuo Gui, Xiaolong Wei et al. (Hefei, China - Coordination Chemistry Reviews).

The Effect of Photobiomodulation on Third Molar Wound Recovery: A Systematic Review with Meta-Analysis - Mdpi.com
Article by Aldo Giansiracusa, Stefano Parrini, Nicola Baldini, Elena Bartali and Glauco Chisci (Siena, Italy - JCM). This meta-analysis underscores the need for further research in this domain, highlighting the existing heterogeneity among studies and the importance of a nuanced understanding of photobiomodulation’s multifaceted effects on postoperative complications.

The efficiency of human fat products in wound healing: A systematic review and meta‐analysis - Nih.gov
Article by Yutian Xiao, Mengqi Nie, Wenqing Xu, Jinglve Zhang et al. (Changsha, China - Int Wound J.). The authors' research findings supported the efficiency of human fat products and demonstrated a high degree of safety in the clinical practice of wound management.

Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1−/− mice - Biomedcentral.com
Article by Barbara Gawronska-Kozak, Sylwia Machcinska-Zielinska, Katarzyna Walendzik, Marta Kopcewicz et al. (Poland, Finland - BMC Biology). The authors' data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1−/− DFs and demonstrate that the introduction of Foxn1 and Hif-1α into the wounded skin of regenerative Foxn1−/− mice activates reparative/scar-forming healing.

Multifunctional hydrogel dressing promotes wound healing by reprogramming the infection-related wound microenvironment - Springer.com
Abstract by Yaqi Xi, Shuo Zhang, Meng Wu, Jiajin Tu et al. (Ganzhou, China - Journal of Materials Science).

Malignant wounds: Management in practice - Wounds-uk.com
Article by Karen Ousey, Susy Pramod, Trudie Clark, Luxmi Dhoonmoon et al. A malignant wound is a devastating complication associated with cancer. Malignant wounds can be extremely challenging – and distressing – for patients, family members and clinicians. They are unique wounds to manage, which can be very different from any other wound type.

Effect of negative pressure wound therapy on the incidence of deep surgical site infections after orthopedic surgery: a meta-analysis and systematic review - Biomedcentral.com
Article by Huan Liu, Ge Zhang, An Wei, Hao Xing et al. (Shandong, China - Journal of Orthopaedic Surgery and Research). The results of the authors' study indicate that the prophylactic use of NPWT reduces the incidence of deep SSIs following orthopedic trauma surgery when compared to the use of conventional dressings.

Zein spray-dried microparticles loaded with chemically modified curcumin for active wound healing - Sciencedirect.com
Article by Chiara Gnocchi, Martina Lenzuni, Fabrizio Fiorentini, Danila Merino et al. (Italy, USA - Journal of Drug Delivery Science and Technology). The authors' promising results highlight their formulations’ ability to reduce oxidative stress inside the cells, representing a promising strategy to address the problem of chronic wounds, supporting the body in overcoming the inflammatory stage.

Researchers uncover connection between two common diabetes drugs with implications for foot ulcer healing - News-medical.net
Article by Pooja Toshniwal Paharia. A recent ACS Pharmacology & Translational Science study examined the biogenic amines and small-molecule metabolites in diabetic foot ulcer (DFU) wound exudates to identify their potential roles in wound healing. Patients who take both insulin injections and oral metformin have significantly increased amounts of metformin found in wounds.

A multicentre clinical trial evaluating the outcomes of two application regimens of a unique keratin-based graft in the treatment of Wagner grade one non-healing diabetic foot ulcers - PubMed
Abstract by David G Armstrong, Dennis P Orgill, Robert D Galiano, Paul M Glat et al. (USA - Int Wound J.).

Retarded Healing of Wounds - Sciencedirect.com
Abstract by Lionel Gold (Philadelphia, USA - Dental Clinics of North America).

The use of PICO™ single-use negative pressure wound therapy in the community settings - PubMed
Abstract by Annemarie Brown (Essex, UK - Br J Community Nurs.).

A Rare Case of Extensive Hydrofluoric Acid Burn - PubMed
Abstract by Gaozhong Hu, Ziqin Shu, Yuan Li and Huapei Song (China - J Burn Care Res.).

Maggot extract accelerates skin wound healing of diabetic rats via enhancing STAT3 signaling - Plos.org
Article by Mo-Li Wu, Zhe-Ming Yang, Hai-Chao Dong, Hong Zhang et al. (Dalian, China - Plos One). Maggot extract would be an alternative and/or adjuvant candidate for the better management of diabetic skin wounds because of its activity in enhancing STAT3 activation.

Advancing skin wound healing with bioactive materials - Theacademic.com
Article by Naimeh Mahheidari, Mohammad Kamalabadi Farahani and Majid Salehi. Skin, our body’s largest organ, serves as a protective shield against external threats. However, it is also prone to injuries requiring effective healing care. This blog explores the innovative approach of utilizing a hydrogel wound dressing infused with bioactive materials like alginate/CMC, diopside nanoparticles, BTX-A, and chorion membrane to accelerate tissue regeneration and promote skin recovery.

Wound Closure Promotion by Leucine-Based Pseudo-Proteins: An In Vitro Study - Mdpi.com
Article by Mariam Ksovreli, Tinatin Kachlishvili, Mariam Skhvitaridze, Lili Nadaraia et al. (Georgia, France - IJMS). LPP films offer a promising approach to improving wound care and could lead to more effective treatments for complex wounds.

Combined use of insulin and metformin enhances diabetic foot ulcer healing, research shows - News-medical.net
Researchers from Michigan State University and South Shore Hospital have uncovered that the combination of two common diabetes drugs -; injectable insulin and orally-administered metformin -; increases the amount of metformin at the wound site. As metformin can accelerate wound healing, this could be welcome news for the 18.6 million people worldwide (1.6 million in the U.S.) who develop a diabetic foot ulcer, or DFU, in their lifetimes.

Effectiveness of Negative Pressure Wound Therapy in Treating Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Hmpgloballearningnetwork.com
Article by Michel Marcos Dalmedico, Angela do Rocio Fedalto, Waleska Alves Martins, Chayane Karla Lucena de Carvalho et al. (Curitiba, Brazil - Wounds). Although the articles included in this systematic review have limitations regarding methodological quality and clinical heterogeneity, the results showed the potential benefit of NPWT in healing and wound area reduction. These outcomes are essential in the prevention of amputation in patients with DFU.

Advances in stem cell therapy for diabetic foot - Frontiersin.org
Article by Yinfeng Xia, Ping Wu, Hong Chen and Zhiyong Chen (Chongqing, China - Front. Genet.). Despite numerous studies confirming the efficacy of stem cell therapy in treating DFU, there is still a need for the establishment of standardized treatment protocols. Although numerous studies have shown that stem cell therapy for DFU is real and effective, there has not yet been a standardized treatment protocol. This article reviews studies related to stem cell therapy for DFU, looking at the mechanism of action, types of stem cells, and modes of administration.

Meleney’s Gangrene of the Abdomen Managed With Serial Debridement and Negative Pressure Wound Therapy: A Case Report - Cureus.com
Article by Aditya Sharma, Vivek K. Katiyar, Satyendra K. Tiwary, Puneet Kumar and Ajay K. Khanna (Varanasi, India). The authors report the case of a 45-year-old male patient with type 2 diabetes mellitus who presented to their facility after being bitten by an insect and exhibiting symptoms of Meleney's gangrene of the abdomen.

New surgical technology can ‘light up’ bacteria in wounds, helping to prevent infections - Foxnews.com
Article by Melissa Rudy. A new medical technology that uses fluorescent light has shown to be effective in detecting missed bacteria, according to new research led by University of Southern California, Los Angeles (USC).

An Alternative Unna Boot Application Technique - Woundsource.com
In this insight from WoundCon's Wound to the Wise session, Andrea Sinn, CWOCN shows her tip for applying Unna boots in a way that increases patient comfort.

Wound Care Documentation Pearls for Successful Compliance - Woundsource.com
Article by Kathleen D. Schaum. Wound/ulcer management professionals typically perform a high volume of a few specific procedures. Therefore, they often cannot prevent prepayment and postpayment audits. However, these professionals may prevent most prepayment claim denials and repayments after postpayment audits by painting a detailed picture of each patient’s condition at each encounter and thoroughly documenting the where, when, who, why, and what that the provider performed at each encounter.

Cognitive status, psychological state and needs of caregivers for elderly patients with home-induced pressure injuries: a qualitative study - PubMed
Abstract by Jiaqi Sun, Ping Yu, Linling Zhou and Xiaojie Lu (China - Br J Hosp Med (Lond)).

Bioengineering Approaches and Novel Biomaterials to Enhance Sternal Wound Healing after Cardiac Surgery: A Crosstalk Between Innovation and Surgical Practice - Mdpi.com
Article by Chiara Ferrisi, Francesco Loreni, Antonio Nenna, Omar Giacinto et al. (Rome, Italy - J. Funct. Biomater.). The use of antibiotic treatments suspended in poly-D,L-lactide and polyethylene oxide and electrospun into nanofibers, or in sponges, has been shown to inhibit bacterial biofilm production. Additionally, growth factors can be incorporated into 3D bioresorbable scaffolds with the aim of constituting a structural and biological framework to organize and expedite the healing process.