Hungarian Wound Care Society

Infliximab accelerates wound healing in diabetic mice by aggravating macrophage polarization - Jomh.org
Article by Mei Chen, Meihong Da, Qiao Yan and Fei Wang (Nanjing, China - JOMH). The authors findings demonstrate that in diabetic mice, INF facilitates wound healing by modulating macrophage polarization, and refrained the NF-κB pathway, supporting INF as a promising treatment approach for improving wound healing in diabetics.

Comparative Study of the Healing Process of Disbudding Wounds in Calves Using Bepanthene® or an Antibiotic Spray - Mdpi.com
Article by Gabriela Martins and George Stilwell (Lisboa, Portugal - Animals). The findings of the present study support the use of Bepanthene®, allowing for a reduction in the use of antimicrobials in production animals without impeding healing.

Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats - Nature.com
Article by Jehan Barakat Alamre, Huda Alkreathy, Ahmed S. Ali, Abdelbagi Alfadil and Sahar S. Alghamdi (Saudi Arabia - Scientific Reports). The present work showed that 3-hydrazinylquinoxaline-2-thiol holds great potential for the treatment of diabetic wounds.

Healing wounds with plasma-activated hydrogel therapy - Cell.com
Article by Sumyea Sabrin, Sung-Ha Hong, Debabrata K. Karmokar et al. (Australia, UK - Trends in Biotechnology). This opinion article describes PAHT for wound treatment and provides an overview of current research and outstanding challenges in translating the technology for medical use.

Evidence of Potential Natural Products for the Management of Hypertrophic Scars - Sagepub.com
Article by Thunyaluk Meetam, Apichai Angspatt and Pornanong Aramwit (Thailand - Journal of Evidence Based Integrative Medicine). Although the natural products showed beneficial effects in both in vitro and in vivo studies of potential anti-scarring agents, there was limited clinical evidence to support their efficacy due to the limited quality of the studies, with individual flaws including small sample sizes, poor randomization, and blinding, and short follow-up durations.

Diving Deep Into Healing: The Promising Role of Fish Skin in Wound Recovery - Hmpgloballearningnetwork.com
Article by Shahnai Basharat, Sarosh Malik, Hodaa Usama Abdus Samad and Mian Anjum Murtaza (Pakistan). The mechanisms discussed in this review support the finding that fish skin is a promising candidate with a strong potential to naturally boost the wound healing process in clinical settings.

Emerging Nanotherapeutic Approaches for Diabetic Wound Healing - Dovepress.com
Article by Shaoyan Shi, Leiming Hu, Dong Hu, Xuehai Ou and Yansheng Huang (Xi’an, China - International Journal of Nanomedicine). This review paper provides a comprehensive overview of the latest advancements in nanotherapeutics for diabetic wound treatment. We discuss various nanomaterials and delivery systems employed in these emerging therapies. Furthermore, we explore the integration of biomaterials to enhance the efficacy of nanotherapeutic interventions.

Protein from gut worms accelerates skin regeneration and reduces scarring - News-medical.net
Researchers at Rutgers University in New Jersey have discovered that a protein produced by parasitic worms in the gut enhances wound healing in mice. The study, to be published August 23 in the journal Life Science Alliance (LSA), reveals that applying the protein to skin wounds speeds up wound closure, improves skin regeneration, and inhibits the formation of scar tissue. Whether the protein can be harnessed to enhance wound healing in human patients remains to be seen.

The Successful Treatment of Multi-Resistant Colonized Burns with Large-Area Atmospheric Cold Plasma Therapy and Dermis Substitute Matrix – A Case Report - Mdpi.com
Article by Moritz R. Milewski, Frederik Schlottmann, Vincent März, Thorben Dieck and Peter M. Vogt (Hannover, Germany - EBJ). This case report illustrates the importance of atmospheric cold plasma therapy in burn surgery. However, larger case series and randomized controlled trials in specialized centers are needed to assess its place in future clinical practice.

Fashioning an Alginate for Difficult Wound Dimensions - Woundsource.com
In this insight from WoundCon's Wound to the Wise session, Diannne Rudolph demonstrates a simple trick for customizing an alginate dressing for a tunneling or undermined wound.

Nitric Oxide as an Efficient Antimicrobial Treatment for Second-Degree Burn Wounds - Oup.com
Abstract by Stephen C Davis, Joel Gil and Michael Solis (Miami, USA - Military Medicine).

Natural Regenerative Hydrogels for Wound Healing - Mdpi.com
Article by Mariana Chelu, Jose M. Calderon Moreno, Adina Magdalena Musuc and Monica Popa (Bucharest, Romania - Gels). By highlighting recent innovations and ongoing challenges, this article intends to give a detailed understanding of natural hydrogels and their potential to revolutionize regenerative medicine and improve patient healing outcomes.

An Overview of Wound Dressing Materials - Mdpi.com
Article by Tânia Lagoa, Maria Cristina Queiroga and Luís Martins (Évora, Portugal - Pharmaceuticals). Wounds can be classified into acute or chronic, depending essentially on the duration of the healing process, which is associated withextent and depth of the wound, localization, the level of infection, and the patient’s health status. For each kind of wound and respective healing stage, there is a more suitable dressing.

Lipid-based nanosystems for wound healing - PubMed
Abstract by Rita Cortesi, Maddalena Sguizzato and Francesca Ferrara (Ferrara, Italy - Expert Opin Drug Deliv.).

Abstract Submission - EWMA-GNEAUPP 2025 - Ewma.org
Abstracts submitted in English are evaluated by the EWMA Scientific Committee and considered for the English spoken programme. Submission deadline: 30 October 2024, 23:59 CET

Exploring the impact of xylazine on wound care needs - News-medical.net
The animal tranquilizer xylazine is increasingly found in the illicit opioid supply nationwide, leading to severe wounds among people who use drugs. New research led by a University of Pittsburgh physician-scientist and published in Drug and Alcohol Dependence seeks to understand the wound care experiences of this population.

Therapeutic Potential of a Biodynamic Supplement on Skin Pressure Ulcers: A Randomized Clinical Study - Mdpi.com
Article by Pasquale Ferorelli, Manfred Doepp, Stefano Lenzi, Roberto Rovelli et al. (Italy, Germany, Belgium - Biomedicines). The results obtained, confirmed by various tests and recognized by the scientific community, allow us to conclude that treatment with the mentioned products could represent a new and effective strategy for the treatment of pressure ulcers.

In vitro and in vivo evaluation of the diabetic wound healing properties of Saffron (Crocus Sativus L.) petals - Nature.com
Article by Mohammad Hasan Soheilifar, Dara Dastan, Nastaran Masoudi-Khoram, Hoda Keshmiri Neghab et al. (Iran - Scientific Reports). C. sativus petal extract has potential as a herbal treatment to improve the healing of diabetic wounds.

Pogostemon cablin Extract Promotes Wound Healing through OR2AT4 Activation and Exhibits Anti-Inflammatory Activity - Mdpi.com
Article by Jung Ha Choo, Daehyun Kim, Kyoungin Min, So Young Lee and Nae Gyu Kang (Seoul, Korea - CIMB). The authors' findings suggest that PCE holds therapeutic potential by promoting cell proliferation, facilitating wound healing, and exerting anti-inflammatory effects.

Dynamic regulation of tissue fluidity controls skin repair during wound healing - Cell.com
Article by Rahul M. Sarate, Joel Hochstetter, Manon Valet, Otger Campàs et al. (Belgium, UK, Germany, Denmark - Cell). Wound healing involves dynamic changes in tissue fluidity. EGFR/AP1 axis controls a regenerative state that regulates tissue fluidity and repair.

Hypochlorous Acid for Wound Healing in Diabetic Rats: Effect on MMP-9 and Histology - Dovepress.com
Article by Dita Mutiara Irawan, Ronny Lesmana and Edhyana Sahiratmadja (Indonesia - Clinical, Cosmetic and Investigational Dermatology). Topical agent, in this case HOCl ion, shows good results and can be used as an option in the management of diabetic wounds and MMP-9 can be used as a predictive marker in the management of diabetic wounds.

Negative pressure wound therapy for extensive soft tissue defects of the lower extremity in a teenager: A case study - Wiley.com
Article by Rainer Stanek, Eva-Maria Pointner, Katja Canigiani de Cerchi, Gerhard Pomberger et al. (Vienna, Austria - Clinical Case Reports). This case study describes the use of a tubular bandage encompassing the whole limb to deliver successful NPWT in the treatment and reconstruction of extensive soft tissue damage extending from the right lower extremity to the hip in a 14-year-old female.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells - Nature.com
Article by Xinhui Li, Tiantian An, Yang Yang, Zhaoyu Xu et al. (Sichuan, China - Cell Death & Disease). The authors leverage the wound-induced hair neogenesis (WIHN) models in adult mice to explore the correlation between degree of damage and the healing process and outcome. The multimodal analysis, in combination with single-cell RNA sequencing help to explore the difference in wounds of gentle and heavy damage degrees, identifying the potential role of toll-like receptor 9 (TLR9) in sensing the injury and regulating the immune reaction by promoting the migration of γδT cells.

Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis - PubMed
Abstract by Deisi Romitti Maglia, Bruna do Amaral Ferreira Souza and Fernanda Visioli (Porto Allegre, Brazil - Clin Oral Investig.).

Omega Fatty Acid-Based Therapy for Healing of Recalcitrant Wounds in Patients with Complex Comorbidities - PubMed
Abstract by Jacob Reinkraut, Adeen Khokhar, Sarah Abdou, Sonya Wali and Desmond Bell (USA - Adv Skin Wound Care).

Advancements and Challenges of Nanostructured Lipid Carriers for Wound Healing Applications - Dovepress.com
Article by Nasrul Wathoni, Cecep Suhandi, Khaled M Elamin, Ronny Lesmana et al. (Indonesia - International Journal of Nanomedicine). NLCs represent an effective nanocarrier system for optimizing the bioavailability of active pharmacological ingredients in the context of wound healing.

Use of Non-Thermal Plasma as Postoperative Therapy in Anal Fistula: Clinical Experience and Results - Mdpi.com
Article by Régulo López-Callejas, Pasquinely Salvador Velasco-García, Mario Betancourt-Ángeles, Benjamín Gonzalo Rodríguez-Méndez et al. (Mexico - Biomedicines). The authors' findings underscore the efficacy of non-thermal plasma as a postoperative therapy for anal fistula, enhancing healing and recovery outcomes without increasing complication risks.

Necrotizing Fasciitis of the Lower Extremity Treated With Continuous Local Antibiotic Perfusion - Cureus.com
Article by Nana Tomaru, Hideharu Nakamura, Takaya Makiguchi, Yumi Yamada and Satoshi Yokoo (Japan). The authors present two cases of lower extremity NF treated with intra-soft tissue antibiotic perfusion. In both cases, effective infection control and accelerated wound healing were achieved, leading to wound closure.

Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis - Bmj.com
Article by Yan Jiang, Qijian Zhang, Hongjuan Wang, Maritta Välimäki et al. (Changsha, China - BMJ Open). Silver dressings, demonstrating a comparable healing rate to iodine dressings, significantly reduce healing time, suggesting their potential as a superior adjunct in wound care.

Reconstructive Surgery of the Head and Neck in Organ Transplant Recipients: A Case Report and a Review of the Literature - Mdpi.com
Article by Andrea Rampi, Lara Valentina Comini, Andrea Galli, Bright Oworae Howardson et al. (Italy - JCM). New developments, including intraoperative monitoring of flap vascularization through indocyanine green fluorescence video-angiography and the prophylactic application of negative pressure wound therapy, when feasible, may be particularly beneficial for high-risk patients.

Treating radiation wounds with aspirin hydrogels - Sciencedaily.com
Radiation is a powerful tool for treating cancer, but prolonged exposure can damage the skin. Radiation-induced skin injuries are painful and increase a person's chances of infection and long-term inflammation. Now, researchers report an aspirin-containing hydrogel that mimics the nutrient-rich fluid between cells and accelerates healing of skin damaged by radiation in animals.

Approaching Lymphedema in Patients Receiving Palliative Care for Cancer - Woundsource.com
How might clinicians approach lymphedema in patients with advanced cancer receiving palliative care? A recent piece published in ePlasty looked at one center’s experience and findings.

Tips and Pearls on Upper Extremity Compression: Part 1 - Hand Preparation - Woundsource.com
Brandy McKeown demonstrates initial steps in achieving upper extremity compression.

Platelet-Rich Plasma in Pediatric Surgery: A Comprehensive Review - Mdpi.com
Article by Marco Di Mitri, Simone D’Antonio, Edoardo Collautti, Annalisa Di Carmine et al. (Bologna, Italy - Children). Key findings from clinical studies and randomized controlled trials are summarized, highlighting the efficacy of PRP therapy in accelerating wound healing, reducing pain, and improving patient recovery. Despite promising results, challenges and controversies surrounding PRP therapy persist, including variability in preparation protocols and optimal dosing regimens.

3D Bioprinting Techniques and Bioinks for Periodontal Tissues Regeneration – A Literature Review - Mdpi.com
Article by Nátaly Domingues Almeida, Camila Alves Carneiro, Andrea Carvalho de Marco, Vinicius Carvalho Porto and Rodrigo França (Brazil, Canada - Biomimetics). This paper aims to review the different types of bioink formulations and 3D bioprinting techniques used in periodontal tissue regeneration.

Ultrasound in Wound Healing - Physiomed.com
Therapeutic ultrasound is utilized by physical therapists to deliver a high frequency mechanical vibration to facilitate healing at a cellular level. Therapeutic ultrasound is often used by physiotherapists to reduce pain, increase circulation and increase mobility of soft tissues. Additionally, the application of ultrasound can be helpful in the reduction of inflammation, reducing pain and the healing of injuries and wounds.

Diamond-Augmented Zinc Oxide Technology Demonstrates Efficacy in Wound Healing, Collagen Synthesis, and More - Dermatologytimes.com
Article by Emma Andrus. Diamond-augmented zinc oxide (ND-ZnO) technology proved efficacious in enhancing wound healing, improving collagen synthesis, and active ingredient delivery via skin permeation, according to a study published in the Journal of Cosmetic Dermatology.

Challenges in Biofilm Identification in Diabetic Foot Infections: Review of Literature - PubMed
Abstract by Adam Astrada, Gojiro Nakagami and Hiromi Sanada (Indonesia, Japan - Int J Low Extrem Wounds).

Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing - Nature.com
Article by Sergei Butenko, Raji R. Nagalla, Christian F. Guerrero-Juarez, Francesco Palomba et al. (Irvine, USA - Nature Communications). The authors' findings suggest that tuning the physical properties of hydrogels can guide cellular responses and improve healing, offering insights for designing better biomaterials for wound treatment.

Calcium Hydroxyapatite in Its Different Forms in Skin Tissue Repair: A Literature Review - Mdpi.com
Article by Paola Tatiana Espinosa Cruel, Camila Pascoal Correia dos Santos, Thalia Malave Cueto, Lisbeth Patricia Vasquez Avila et al. (Brazil - Surgeries). The authors' finding indicate that calcium hydroxyapatite (HAp) and nano-HAp in skin regeneration are promising, especially when combined with other biomaterials, offering antimicrobial and anti-inflammatory benefits and stimulating angiogenesis.

The Use of Acellular Products in Venous Leg Ulcers: A Narrative Review - Hmpgloballearningnetwork.com
Article by Tokoya Williams, Stuti P. Garg, Keenan Fine, Bradley Melnick et al. (Chicago, USA - Wounds). Acellular products appear to have the potential to support healing in VLUs. However, more large-scale randomized controlled trials that provide level I evidence are needed.

Enhanced Negative Pressure Wound Therapy Shortens Hospital Stay for Major Burn Patients: Case Series - Lww.com
Article by Andrea Donoso-Samper, David Camacho-Obando, Santiago Garzón and Viviana Gómez-Ortega (Bogotá, Colombia - Plastic & Reconstructive Surgery-Global Open). All burn injuries either healed completely or demonstrated adequate skin graft survival and recovery in follow-ups. All the patients exhibited a decrease in the LOS, despite experiencing systemic complications arising from distributive shock.

Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure - Science.org
Article by Rajaram Kaveti, Margaret A. Jakus, Henry Chen, Bhavya Jain et al. (Raleigh, USA - Science Advances). The results demonstrate the water-powered, electronics-free dressings’ potential as an effective and more practical wound treatment dressing.

Customized Negative Pressure Wound Therapy: Innovative Design in Polyurethane Foam for Complex Burn Reconstruction - Lww.com
Article by Juan Sebastián Amaris-Acuña, Bibiana Mendoza-Toro, David Camacho-Obando and Viviana Gómez-Ortega, Viviana (Bogotá, Colombia - Plastic & Reconstructive Surgery-Global Open). The authors highlight the effectiveness of incorporating NPWT across all burn treatment phases, expediting recovery and ensuring optimal functional outcomes for patients. Surgeons can customize different NPWT foam shapes that facilitate its use on difficult-to-treat areas, allowing for a faster recovery and better rehabilitation outcomes.

Characteristics of chronic ulcer patients by gender and ulcer aetiology from a multidisciplinary wound centre - PubMed
Abstract by Katarina Kuikko, Teea Salmi, Heini Huhtala and Teija Kimpimäki (Tampere, Finland - Int Wound J.).

A retrospective cohort study on enhanced recovery after surgery (ERAS) in patients with diabetic foot ulcer - Nature.com
Article by Xinyuan Qin, Yefeng Yin, Lei Liu, Lei Gao, Siyang Han et al. (Beijing, China - Scientific Reports). By reducing the length of stay and hospital costs, and by minimizing perioperative complications, the ERAS protocol improves the quality and efficacy of treatment intervention in patients with DFU who underwent surgical procedures.

A review on traditional medicine used for burn treatment - Academic.oup.com
Article by Soodabeh Hoveidamanesh, Rana Irilouzadian, Tooran Bagheri, Mahdy Saboury et al. (Tehran, Iran - Journal of Burn Care & Research). All of the studies showed equal or improved effects compared to common treatments. Aloe vera, Centella asiatica, and Arnebia euchroma were the most common plants.

Therapeutic application of mesenchymal stem cell-derived exosomes in skin wound healing - Frontiersin.org
Article by Yunhan Sun, Shun Zhang, Yukai ShenYukai Shen, Haoyang Lu et al. (Shandong, China - Front. Bioeng. Biotechnol.). In this review, authors summarize the biogenesis and characteristics of exosomes, the role of exosomes in wound healing, and the therapeutic applications of modified-exosomes in wound healing. The challenges and prospects of exosomes in wound healing are also discussed.

The Potential of Fish Oil Components and Manuka Honey in Tackling Chronic Wound Treatment - Mdpi.com
Article by Jenna Clare, Martin R. Lindley and Elizabeth Ratcliffe (UK, Australia - Microorganisms). This review considers two prominent natural substances with established manufacturing and global distribution-marine based fatty acids (including their metabolites) and manuka honey—their function as antimicrobials and how they can aid in wound repair, two important aspects leading to resolution of chronic wounds.

Clinical and Hematological Correlates of Hemolytic Anemia in Diabetic Foot Ulcer Patients: A Prospective Observational Study - Cureus.com
Article by Virendra C. Patil, Harsha V. Patil, Dhairyasheel D. Patil and Mohammad Asim Khan (India). This study aimed to investigate the clinical and hematological correlates of hemolytic anemia in patients with DFU and to elucidate the potential mechanisms underlying this complication and its impact on wound healing.

"How much my wound is healed..." Check in real time with surgical suture and needle! - Eurekalert.org
A research team has successfully developed an electronic suture that can monitor changes in inflammation levels around wounds in real time. The electronic suture is expected to contribute significantly to wound care and personalized care across various medical fields.

Chitosan-based self-healing hydrogel dressing for wound healing - Sciencedirect.com
Article by Xingyu Zhang, Yongping Liang, Shengfei Huang and Baolin Guo (Xi'an, China - Advances in Colloid and Interface Science).

Bacteria originally found in faeces help chronic wounds heal - Newscientist.com
Article by Rohini Subrahmanyam. The bacterium Alcaligenes faecalis was first discovered in faeces – but it turns out to have healing properties for the chronic wounds that affect people with diabetes.

Comparative Analysis of Exosomes and Extracellular Microvesicles in Healing Pathways: Insights for Advancing Regenerative Therapies - Mdpi.com
Article by Mikołaj Sędzik, Katarzyna Rakoczy, Jakub Sleziak, Michał Kisiel et al. (Wroclaw, Poland - Molecules). This article aims to gather and analyze current knowledge on those promising particles, their characteristics, and their potential clinical implementations.

Analysis of therapeutic effect of silver-based dressings on chronic wound healing - Wiley.com
Article by Kaitao Liang, Yan Liu and Fengting Jiang (China - International Wound Journal). The authors' findings suggested that the silver-based dressings were able to enhance chronic wound healing rate, shorten the complete healing time and reduce wound infection rate, but had no significant improvement in the reduction on wound surface area.

The muscle pump activator device: From evidence to lived experiences - Wiley.com
Article by R. Gary Sibbald, Ryan S. Q. Geng, Jacqueline Slomovic and Michael Stacey (Canada - International Wound Journal). In this review, the authors present a series of chronic wound patients treated with the MPA device in multicentre clinics to demonstrate the ability of the MPA device to improve wound outcomes, reduce pain and edema and improve patient quality of life.

Insights on the In Vitro Wound Healing Effects of Sedum telephium L. Leaf Juice - Mdpi.com
Article by Giorgio Cappellucci, Alessia Paganelli, Pier Luca Ceccarelli, Elisabetta Miraldi and Marco Biagi (Italy - Cosmetics). The authors' findings suggest that Sedum telephium L. represents a promising candidate in the setting of skin regeneration and repair.

Use of Collagen Powder in Secondary Intention Healing After Mohs Surgery or Excisional Surgery: A Retrospective Study - Hmpgloballearningnetwork.com
When clinically appropriate, granulation assisted by collagen powder should be considered for augmenting secondary intention healing.

The clinical effects of artificial dermis in the treatment of skin and soft tissue defects accompanied by bone or tendon exposure - Sciencedirect.com
Article by Yongfa Zhang, Fuyang Chen, Weiqiang, Zhixian Xu et al. (China - Injury). Artificial dermis treatment is considered a safe and effective alternative therapy for patients with skin and soft tissue defects accompanied by bone or tendon exposure who cannot tolerate or are unwilling to undergo autologous skin flap transplantation.

Decoding the Decade: Exploring the Efficacy of Platelet-Rich Plasma (PRP) in Complex Wound Management - A Comprehensive Study - PubMed
Abstract by Sandeep Shrivastava, Siddharth Patel, Aditya Pundkar, Ankit Jaiswal and Priyal Shrivastava (India - Indian J Orthop.).

Potential Wound Healing and Anti-Melanogenic Activities in Skin Cells of Aralia elata (Miq.) Seem. Flower Essential Oil and Its Chemical Composition - Mdpi.com
Article by Do Yoon Kim, Kyung Jong Won, Yoon Yi Kim, Da Yeon Yoo and Hwan Myung Lee (Korea - Pharmaceutics). The authors' results suggest that AESFEO has beneficial effects on keratinocyte activities related to skin wound healing and melanocyte activities related to inhibition of skin pigmentation.

Pediatric Wound Infections Following 2023 Kahramanmaras Earthquakes: Case Series - Hmpgloballearningnetwork.com
Article by Seyhan Yılmaz, Gulsen Akkoc, Sevgi Aslan Tuncay, Burcu Parlak et al. (Istanbul, Turkey - Wounds). Major disasters such as earthquakes are rare, and infections are the major complications that increase morbidity and mortality. Initial appropriate treatment contributes to improved outcomes, as multidrug-resistant strains are common pathogens in these patients.