Preventing Diabetic Foot Ulcers Through Regular Foot Checks - Woundsource.com
Article by Holly Hovan. Diabetes is extremely prevalent in the United States. The Centers for Disease Control and Prevention (CDC) report that over 10% of the US population has this chronic disease, and 26.8% of older adults (65 and over) are impacted by diabetes, both diagnosed and undiagnosed.
Pressure Injuries and Flap Surgery - Woundsource.com
Patients who develop stage 3 and 4 pressure injuries with prolonged wound chronicity and complexity may require surgical intervention. One surgical method used to encourage healing in pressure injuries is flap surgery, which involves taking a section of skin with an intact blood supply and placing it over the injured area. Flaps play a major role in the healing of wounds with exposed structure.
Effectiveness of ultrasonic debridement on reduction of bacteria and biofilm in patients with chronic wounds: A scoping review - Nih.gov
Abstract by Yukie Kataoka, Mao Kunimitsu, Gojiro Nakagami, Sofoklis Koudounas, Carolina D Weller and Hiromi Sanada (Japan, Australia - Int Wound J.).
Foot ulcers associated with external trauma among people with diabetes: An integrative review of the origin of trauma and outcomes - Nih.gov
Abstract by Ma'en Zaid Abu-Qamar, Vivien Kemp and Lisa Whitehead (Jordan, Australia - Int J Nurs Stud.).
Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing - Mdpi.com
Article by Christina B. Brazel, Jan C. Simon, Jan P. Tuckermann and Anja Saalbach (Germany - JCM).
The authors conclude that insulin resistance in obesity and diabetes prevents the down-regulation of 11β-HSD1, leading to elevated endogenous GC levels in diabetic skin, which could contribute to impaired wound healing in patients with DM.
The sorptivity and durability of gelling fibre dressings tested in a simulated sacral pressure ulcer system - Nih.gov
Abstract by Adi Lustig, Paulo Alves, Evan Call, Nick Santamaria and Amit Gefen (Israel, Portugal, USA, Australia - Int Wound J.).
Negative pressure wound therapy for burn patients: A meta-analysis and systematic review - Nih.gov
Abstract by Dai-Zhu Lin, Yu-Chien Kao, Chiehfeng Chen, Hsian-Jenn Wang and Wen-Kuan Chiu (Taipei, Taiwan - Int Wound J.).
World's first research programme to identify scarring gene launched - Bristol.ac.uk
A world-leading £1.5 million research programme that aims to achieve scar free healing within a generation has been launched by The Scar Free Foundation, the only medical research charity which focuses solely on scarring. The five-year research study led by the University of Bristol will identify the gene(s) that causes scarring and inform future treatments.
6 ways to make a wound heal faster - Medicalnewstoday.com
A wound is an injury that cuts or breaks the skin. Although most wounds heal naturally with time, there are some ways to speed up the healing process.
A systematic review of the scalp donor site for split-thickness skin grafting - Nih.gov
Abstract by Suk Joon Oh (Seoul, Korea - Arch Plast Surg.).
Treatment of Pain in Keloids Using Only a Long-Pulsed 1064 nm Nd:YAG Laser - Nih.gov
Abstract by Payal M Patel, Abnoeal D Bakus, Benjamin C Garden, Olivia Lai, Virginia A Jones and Jerome M Garden (Chicago, USA - Lasers Surg Med.).
Effects of Hsian-tsao (Mesona procumbens Hemsl.) extracts and its polysaccharides on the promotion of wound healing under diabetes-like conditions - Nih.gov
Abstract by Siao-Ling Fan, Jer-An Lin, Sheng-Yi Chen, Jia-Hong Lin, Hsin-Tang Lin, Ying-Yin Chen and Gow-Chin Yen (Taichung, Taiwan - Food Funct.).
Combination application of ultrasonic debridement, methylene blue staining, and negative pressure wound therapy for severe pressure ulcers - Nih.gov
Abstract by Chao Lian, Hai-Li Liu, Yan-Ran Li, Xiao-Jun Liu and Xue-Lei Li (China - Int Wound J.).
Cannabis-Based Medicines as a Novel Approach to Treating Wound-Related Pain - Todayswoundclinic.com
Article by Stefano Armando Biasi and Vincent Maida. Are cannabis-based treatments effective for pain in wound care patients? These authors explore the research, scientific basis, advantages, as well as routes of administration, of cannabis-based medicines in providing pain relief and enhanced wound healing.
Treating Warfarin-Induced Tissue Necrosis With a Hypothermically Stored Amniotic Tissue Graft - Todayswoundclinic.com
Article by Josefine Lin Henriksen, Nana Brandborg Sørensen, Trine Fink, Vladimir Zachar and Simone Riis Porsborg (Aalborg, Denmark - Cells).
This comprehensive review presents an overview of available methodologies to assess the MOA of MSC treatment for distinct wound healing phases. Furthermore, it includes a set of recommendations for the design of highquality clinical studies that can determine the efficacy of MSCs as a therapy for burn wounds.
pdf (800 kB)!
Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies - Mdpi.com
Article by Fatima Zahra Jawhari, Abdelfattah El Moussaoui, Mohammed Bourhia, Hamada Imtara, Hamza Mechchate, Imane Es-Safi, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Samir Ibenmoussa, Dalila Bousta and Amina Bari (Morocco, Palestine, Saudi Arabia, Finland - Molecules).
This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of A. pyrethrum.
The impact of incisional negative pressure wound therapy on the wound healing process after midline sternotomy - Wiley.com
Article by Aref Rashed, Marton Csiszar, Agnes Beledi and Karoly Gombocz (International Wound Journal). INPWT has less effect on the inflammatory phase and appears to have more effect on the proliferation phase through pronounced scar formation.
Role of Nicergoline in Corneal Wound Healing in Diabetic Rats - Researchsquare.com
Article by Amanda Portela, Rafael Moreno, Maria Helena Ribeiro, Fernanda de Andrade, Yale Alves, Mônica Alves and Rodrigo Lira (Brazil).
Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.
A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer - Mdpi.com
Article by Satoshi Takagi,Takuto Oyama, Shiro Jimi, Arman Saparov and Hiroyuki Ohjimi (Japan, Kazakhstan - Healthcare).
This case study indicates that for a chronic/refractory ulcer patient with poor NPWT outcome, combination therapy using micrografting treatment and NPWT could rapidly initiate and enhance granulation tissue formation, creating a favorable bedding for subsequent skin grafting.
Biofilm Formation Reducing Properties of Manuka Honey and Propolis in Proteus mirabilis Rods Isolated from Chronic Wounds - Nih.gov
Abstract by Joanna Kwiecińska-Piróg, Jana Przekwas, Michał Majkut, Krzysztof Skowron and Eugenia Gospodarek-Komkowska (Bydgoszcz, Poland - Microorganisms).
Compression Therapy Is Not Contraindicated in Diabetic Patients with Venous or Mixed Leg Ulcer - Nih.gov
Abstract by Giovanni Mosti, Attilio Cavezzi, Luca Bastiani and Hugo Partsch (Italy, Austria - J Clin Med.)
Role of Negative Pressure Wound Therapy When Performing Elective Open Colectomy - Nih.gov
Abstract by Scott H Nguyen, Ann M Defnet, Brooke A Pati, Dylan M Russell, Suzanne M Gillern, Edward Lin, Patrick S Sullivan and Christopher Yheulon (USA - Surg Infect (Larchmt.))
pdf (710 kB)!
Anacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties - Mdpi.com
Article by Fatima Zahra Jawhari, Abdelfattah El Moussaoui, Mohammed Bourhia, Hamada Imtara, Hamza Mechchate, Imane Es-Safi, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Samir Ibenmoussa, Dalila Bousta and Amina Bari (Morocco, Palestine, Saudi Arabia, Finland - Molecules).
This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of A. pyrethrum.
Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats - Dovepress.com
Article by Karthik Gourishetti, Raghuvir Keni, Pawan Ganesh Nayak, Srinivas Reddy Jitta, Navya Ajitkumar Bhaskaran, Lalit Kumar, Nitesh Kumar, Nandakumar Krishnadas and Rekha Raghuveer Shenoy (Manipal, India - International Journal of Nanomedicine).
Results indicate that sesamol-PLGA nanosuspension significantly promotes the acceleration of wound healing in diabetic foot ulcers by restoring the altered wound healing process in diabetic condition.
The effect of hyperbaric oxygen on compromised grafts and flaps - Nih.gov
Abstract by Shawna Kleban and Richard C Baynosa (Las Vegas, USA - Undersea Hyperb Med.).
Pressure Injury Prevention: A Survey - Nih.gov
Abstract by Sam Mansfield, Katia Obraczka and Shuvo Roy (USA - IEEE Rev Biomed Eng.).
Herbs as old potential treatments for lymphedema management: A systematic review - Nih.gov
Abstract by Zahra Sheikhi-Mobarakeh, Hossein Yarmohammadi, Parisa Mokhatri-Hesari, Shirin Fahimi, Ali Montazeri and Ghazaleh Heydarirad (Tehran, Iran - Complement Ther Med.).
Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals - Springeropen.com
Article by Shobana Gunasekaran, Agnel Arul John Nayagam and Rameshkannan Natarajan (Tiruchirappalli, India - International Journal of Phytomedicine and Phytotherapy).
It was concluded that the topical application of herbal ointment exhibited significant wound healing activity in excision wounded rats as evidenced by increased wound contraction and collagen synthesis.
Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds - Nih.gov
Abstract by Ying Wang, Zhuo Feng, Meifeng Yang, Lin Zeng, Bu'er Qi, Saige Yin, Bangsheng Li, Yilin Li, Zhe Fu, Longjun Shu, Chen Fu, Pan Qin, Yi Meng, Xiaojie Li, Ying Yang, Jing Tang and Xinwang Yang (Kunming, China - Pharmacol Res.).
Pending questions in venous ulcers management. Report from a Symposium of the World Union of Wound Healing Societies International Congress - Pagepressjournals.org
Article by Olle Nelzen, Ferdinando Mannello and Anneke Andriessen (Italy, Sweden, The Netherlands).
Venous ulcers represent the most frequent ulcers and have a high clinical and socioeconomic significance. Nevertheless, pending questions remain on epidemiology, genetic and biomolecular mechanisms, contraindications and risk factors of compression therapy, role of pharmacological therapy.
Procyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2 - Nih.gov
Abstract by Jiawei Fan, Hairong Liu, Jinwu Wang, Jiang Zeng, Yi Tan, Yashu Wang, Xiaoping Yu, Wenlian Li, Peijian Wang, Zheng Yang and Xiaozhen Dai (China, USA - J Cell Mol Med.).
Silicone adhesive multilayer foam dressings as adjuvant prophylactic therapy to prevent hospital-acquired pressure ulcers: a pragmatic non-commercial multicentre randomised open label parallel group medical device trial - Nih.gov
Abstract by D Beeckman, A Fourie, C Raepsaet, N Van Damme, B Manderlier, D De Meyer, H Beele, S Smet, L Demarré, R Vossaert A de Graaf, L Verhaeghe, N Vandergheynst, B Hendrickx, V Hanssens, H Keymeulen, K Vanderwee, J Van De Woestijne, S Verhaeghe, A Van Hecke, I Savoye, J Harrison, F Vrijens and F Hulstaert (Belgium, Ireland, Sweden - Br J Dermatol.).
Prophylactic dressings in the prevention of pressure ulcer related to the use of personal protective equipment by health professionals facing the Covid-19 pandemic: a randomized clinical trial - Nih.gov
Abstract by Renata Cristina Gasparino, Maria Helena Melo Lima, Ana Railka de Souza Oliveira-Kumakura, Vanessa Abreu da Silva, Mariana de Jesus Meszaros and Ivan Rogério Antunes (Brazil - Wound Repair Regen.).
Obtaining chitin, chitosan and their melanin complexes from insects - Nih.gov
Abstract by Adelya Khayrova, Sergey Lopatin and Valery Varlamov (Moscow, Russia - Int J Biol Macromol.).
Two Methods of NPWT for Wound Management and Patient Satisfaction - Woundresearch.com
Researchers develop 3-D dressing to heal wounds - Medicalxpress.com
Researchers at ITMO University and the University of Toronto have developed a material based on gelatin and nanocrystalline cellulose that can fight off antibiotic-resistant bacteria and speed up the wound healing process. In the future, the material could be used in the production of gel-based wound dressing.
Evaluation of antimicrobial photodynamic therapy on wounds infected by Staphylococcus aureus in animal models - Nih.gov
Abstract by Sepehr Torabi, Khojasteh Joharchi, Katayoun Am Kalhori, Mona Sohrabi and Reza Fekrazad (Iran - Photodiagnosis Photodyn Ther.).
Antibiotic-free combinational hyaluronic acid blend nanofibers for wound healing enhancement - Nih.gov
Abstract by Mohamed R El-Aassar, Nagham G El-Beheri, Mona M Agwa, Hoda M Eltaher, Mostafa Alseqely, Wagih S Sadik and Labiba El-Khordagui (Egypt - Int J Biol Macromol.).
The use of negative-pressure wound therapy over a cultured epithelial autograft for full-thickness wounds secondary to purpura fulminans in an infant - Nih.gov
Abstract by Benjamin Kah Liang Goh, Alvin Wen Choong Chua, Khong Yik Chew, Gavin Chun-Wui Kang, Li-Wei Chiang, Bien-Keem Tan and Savitha Ramachandran (Singapore - Arch Plast Surg.).
Two Methods of NPWT for Wound Management and Patient Satisfaction - Woundresearch.com
A Prospective Multisite Observational Study Incorporating Bacterial Fluorescence Information Into the UPPER/LOWER Wound Infection Checklists - Woundresearch.com
Article by Rosemary Hill and Kevin Woo (Wounds). The authors's results suggest that the UPPER/LOWER checklist and fluorescence imaging work in a complementary manner to effectively identify wounds with high bacterial burden at the point-of-care.
Two Methods of NPWT for Wound Management and Patient Satisfaction - Woundresearch.com
The Pathophysiology of Skin Failure vs. Pressure Injury: Conditions That Cause Integument Destruction and Their Associated Implications - Woundresearch.com
Article by Michael Bain, Junko Hara and Marissa J. Carter (Wounds). Clinicians need to better understand the pathophysiology and classification of integument injuries by underlying etiologies both avoidable and unavoidable. A more accurate diagnosis would lead to more appropriate treatment strategies, an improved quality of care for affected patients, less wasted resources and reduced financial penalties for healthcare providers, and decreased medicolegal claims.
Two Methods of NPWT for Wound Management and Patient Satisfaction - Woundresearch.com
NPWT delivery comes in multiple options. Learn from Dr. Jonathan Arnold about the treatment plan to preserve a limb. Hear from the patient, Donald Murphy, about returning to activities of daily living.
Iron loss through wound fluid "may be a pathological contributor" to anaemia in venous leg ulcer patients, pilot study concludes - Iwoundnews.com
Amy Ferris and Keith Harding (UK), and colleagues have landed on a "suitable protocol" for measuring serum and wound fluid iron levels in the context of wound healing, and have identified a potential link between serum iron and wound fluid iron level and systemic anaemia. Presenting the findings of a pilot study of 30 patients at the EWMA’s 30th annual scientific meeting, Ferris said that their results suggest that wound fluid iron loss "may be a pathological contributor to iron deficiency anaemia".
Efficacy of Wound Cleansers on Wound-Specific Organisms Using In Vitro and Ex Vivo Biofilm Models - Nih.gov
Abstract by Rebecca E McMahon, Ann Beal Salamone, Suprena Poleon, Nina Bionda and Joseph C Salamone (USA - Wound Manag Prev.).
The Therapeutic Potential of Cannabinoids for Integumentary Wound Management - Nih.gov
Abstract by Maximillian A Weigelt, Raja Sivamani and Hadar Lev-Tov (USA - Exp Dermatol.).
Atypical Wounds - Woundcarelearningnetwork.com
Article by Emilee Bartolo. Wound classifications of the "usual" wound types include vascular, traumatic, diabetic, pressure, surgical, dehisced, etc.…However, approximately 10-20% of chronic leg wounds are “atypical” in behavior and appearance. This means that the cause of these atypical, chronic leg ulcers is something other than pressure, neuropathy (diabetic or otherwise), or vascular disease, and are caused by an infectious or inflammatory process or response, renal disease, cancer or trauma.
When Prevention Fails: Pressure Injury Management - Woundsource.com
When pressure injury prevention fails as a result of non-adherence, various comorbidities, or gaps in care, it makes a major impact on the nation’s economy and has estimated costs of more than $100 billion in the United States.
Severe Lactational Mastitis With Complicated Wound Infection Caused by Streptococcus pyogenes - Nih.gov
Abstract by Josefine Theresia Maier, Julia Daut, Elisabeth Schalinski, Toni Fischer-Medert and Lars Hellmeyer (Berlin, Germany - J Hum Lact.).
Effectiveness of Multilayered Polyurethane Foam Dressings to Prevent Hospital-Acquired Sacral Pressure Injuries in Patients With Hip Fracture: A Randomized Controlled Trial - Nih.gov
Abstract by Domenica Gazineo, Matteo Chiarabelli, Rosanna Cirone, Paolo Chiari and Elisa Ambrosi (Bologna, Italy - J Wound Ostomy Continence Nurs.).
How a Vitamin D Deficiency Affects Wound Healing - Woundcarelearningnetwork.com
In this video, Laura Swoboda educates clinicians on how adequate vitamin D levels with glycemic control, angiogenesis, and antimicrobial peptide creation affect wound healing, in the wound care community. She points out that, currently, there is no recommendation for vitamin D monitoring or supplementation for extra-skeletal health including, chronic wound care.
Evaluating the antibacterial, antioxidant and wound healing properties of the stem bark extract of Khaya grandifoliola (Welw) CDC (Meliaceae) (African mahogany) - Academicjournals.org
Article by Anna Kwarley Quartey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Phoebe Esinam Goku, Fadila Alidu and Linda Owusu Boateng (Ghana, JMPR).
The outcomes showed that KG was effective as an antibacterial and antioxidant agent, and a wound healing promoter, justifying its reported traditional uses for infections and wound management.
Wound Healing Treatments After Ablative Laser Skin Resurfacing: A Review - Nih.gov
Abstract by Hayley Leight-Dunn, Margot Chima and Elika Hoss (USA - J Drugs Dermatol.).
Ablative Fractional Resurfacing for Chronic Wounds from Traumatic Scarring: A Case Report and Literature Review - Nih.gov
Abstract by Joseph N Mehrabi and Kristen M Kelly (Irvine, USA - J Drugs Dermatol.).
A Primary Care Provider's Guide to Prevention and Management of Pressure Injury and Skin Breakdown in People With Spinal Cord Injury - Nih.gov
Abstract by Nicole R Rosin, Robyn S Tabibi, John D Trimbath and Mary Kristina Henzel (USA - Top Spinal Cord Inj Rehabil.).
Perioperative hypoalbuminemia is a risk factor for wound complications following posterior lumbar interbody fusion - Biomedcentral.com
Article by Zhongyuan He, Kai Zhou, Ke Tang, Zhengxue Quan, Shaoyu Liu and Bao Su (China - Journal of Orthopaedic Surgery and Research).
For patients who underwent single-segment posterior lumbar interbody fusion surgery, we need to pay more attention to perioperative hypoalbuminemia and chronic steroid use, which are more likely to be associated with increased wound complications, hospitalization costs, and length of hospitalization after surgery. Adequate assessment and management of these risk factors will help reduce wound complications and hospital stays for surgical patients and will save medical costs.
Photobiomodulation: systematic review and meta-analysis of the most used parameters in the resolution diabetic foot ulcers - Nih.gov
Abstract by Luan Dos Santos Mendes-Costa, Vanessa Garcia de Lima, Maria Paula Ribeiro Barbosa, Ludmila Evangelista Dos Santos, Suélia de Siqueira Rodrigues Fleury Rosa and José Carlos Tatmatsu-Rocha (Brazil - Lasers Med Sci.).
Millions of Americans Suffer from Chronic Wounds Each Year... - Drexel.edu
Six and a half million Americans suffer with chronic wounds each year, with $25 billion spent annually to treat them. That number is expected to rise, as chronic wound risk increases with age. One in five Americans will be over 65 years old by the year 2030. Also contributing to a projected rise is growing numbers of diabetes and obesity patients—conditions which often coincide with chronic wounds.
Wounds and compression - Nih.gov
Abstract by Viktor Schnabel, Michael P Schön and Kai-Martin Thoms (Göttingen, Germany - Hautarzt.).
Efficacy of a Bioresorbable Matrix in Healing Complex Chronic Wounds: An Open-Label Prospective Pilot Study - Woundresearch.com
Article by Sarah W. Manning, David A. Humphrey, William R. Shillinglaw, Eric Crawford, Gaurav Pranami, Ankit Agarwal and Michael J. Schurr (Wounds).
The micrometer-thick bioresorbable matrix presents a new form factor to wound management, conforming intimately to the underlying wound bed to exert localized and sustained antimicrobial action of noncytotoxic levels of silver. The application of the matrix on the wound surface in protocols of care was safe and well tolerated, and it facilitated improvements in healing of a majority of the stagnant or deteriorating complex chronic wounds.
The Use of Topical Oxygen Therapy to Treat a Calciphylaxis Wound During a Global Pandemic: A Case Report - Woundresearch.com
Article by Windy Cole, Courtney M. Yoder and Stacey Coe (Wounds).
This case, to the authors’ knowledge, is the first to document healing in a calciphylaxis wound with the use of cTOT. Topical oxygen therapy may be a beneficial adjunctive therapy in the treatment of wounds caused by calciphylaxis. Finding creative ways to navigate this current health care crisis is essential to help mitigate risk for vulnerable patients with advanced comorbidities.
Synergistic Effect and Antibiofilm Activity of a Skin and Wound Cleanser - Woundresearch.com
Article by Ann Beal Salamone, Joseph C. Salamone, Rebecca Erin McMahon, Suprena Poleon, Nina Bionda and Peter D’Arpa (Wounds).
Biofilm in chronic wounds impedes the wound healing process. Each biofilm has differing characteristics requiring a multifaceted approach for removal while maintaining a surrounding environment conducive to wound healing. In this study, 3 of the components in a wound cleanser are tested to determine synergy in eradicating biofilms of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in vitro.
Use of Honey Versus Standard Care for Hospital-Acquired Pressure Injury in Critically Ill Children: A Multicenter Randomized Controlled Trial - Nih.gov
Abstract by Jhuma Sankar, A V Lalitha, Ramachandran Rameshkumar, Subramanian Mahadevan, Sushil K Kabra and Rakesh Lodha (India - Pediatr Crit Care Med.).
Combination Therapy of a Bioresorbable Synthetic Polymer Matrix and an Ovine Collagen Dressing for Treatment of a Recurrent Venous Leg Ulcer: A Case Study - Woundcarelearningnetwork.com
Article by James McGuire. In this case study, we examine the long-term clinical effects of a combination therapy consisting of a silver impregnated, bioabsorbable, polymer matrix for wound bed stimulation and control of biofilm underneath an ovine collagen dermal template in the treatment of a recurrent venous leg ulcer. This combination has been successful when used with several cellular and acellular tissue-based products (CTPs), and thus, our aim was to study the effects using a dressing with a similar acellular structure.
Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response - Mdpi.com
Article by Rivka C. Stone, Vivien Chen, Jamie Burgess, Sukhmani Pannu and Marjana Tomic-Canic (USA, IJMS).
Successful bench-to-bedside translation of observations from genomic studies will result in the development of novel anti-fibrotic therapeutics that improve functional quality of life for patients and decrease mortality from fibrotic diseases.
Protective cap for macaque cranial implants promotes wound healing - Nc3rs.org.uk
A new publication in the Journal of Neuroscience Methods presents a novel device developed to promote healing of the wound margin in macaques with cranial implants.
An economic evaluation examining the cost-effectiveness of continuous diffusion of oxygen therapy for individuals with diabetic foot ulcers - Nih.gov
Abstract by Brian C-F Chan and Karen E Campbell (Canada - Int Wound J.).
Fabrication and evaluation of Chitosan/Gelatin/PVA hydrogel incorporating Honey for wound healing applications: An In Vitro, In Vivo Study - Nih.gov
Abstract by Amir Shamloo, Zahra Aghababaie, Homa Afjoul, Mehrzad Jami, Mina Razaghzadeh Bidgoli, Manouchehr Vossoughi, Ahmad Ramazani and Kambiz Kamyabhesari (Tehran, Iran - Int J Pharm.).
Healing wounds without scars - Thenakedscientists.com
Interview with Ryan Driskell. Quickly healing a wound is a key part of our skin’s defence against bacteria and other microbes that could cause infection. The price we pay for that speed, though, is often a scar. But can we make skin regenerate without scarring, or even reproduce complex mini-organs like hair follicles that are also often lost to injury?
Optimizing microenvironment by integrating negative pressure and exogenous electric fields via a flexible porous conductive dressing to accelerate wound healing - Nih.gov
Abstract by Ying Chen, Yi Liang, Jie Liu, Jinrui Yang, Naixin Jia, Chuhong Zhu and Jiaping Zhang (Chongqing, China - Biomater Sci.).
Patient expectations of pressure ulcer prevention in the NHS, healthcare demands and national policy: a critical commentary - Nih.gov
Abstract by Matthew Wynn (Salford, UK - Br J Nurs.).
Transcutaneous application of the gaseous CO 2 for improvement of the microvascular function in patients with diabetic foot ulcers - Nih.gov
Abstract by Miha Finžgar, Helena Ban Frangež, Ksenija Cankar and Igor Frangež (Ljubljana, Slovenia - Microvasc Res.).
Hot Topics in DFU Care - Woundcarelearningnetwork.com
Article by Paul J. Kim. When treating patients with diabetic foot ulcers (DFU), physicians may find several novel modalities effective for noninvasive perfusion imaging. Like all clinical decisions, the entire “body” of perfusion assessment evidence should be taken into account before using.
Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation - Dovepress.com
Article by Ekaterina Vladimirovna Silina, Natalia Evgenievna Manturova, Petr Frantsevich Litvitskiy and Victor Aleksandrovich Stupin (Moscow, Russia).
The present results clarify the action mechanisms of the studied drugs. In addition, the application purposes and different effects of each drug on the different wound healing phases were demonstrated. An assumption on the multi-component treatment advisability under the wound condition objective assessment possibility was made. Findings from this study may assist clinicians in making an informed transition to personalized wound management and achieve better clinical outcomes.
HBOT and Diabetic Foot Ulcers - Woundcarelearningnetwork.com
In this 2:48 video, Marvin Heyboer III discusses his SAWC Fall Virtual session "HBO: An Evidence-based Guide" and how literature regards the relationship between HBOT and diabetic foot ulcers.
Histological and clinical evaluation of wound healing in pressure ulcers: a novel animal model - Nih.gov
Abstract by Diana G Sami and Ahmed Abdellatif (New Cairo, Egypt - J Wound Care).
Dehydrated placental allograft (DPA) for the management of diabetic foot ulcers – a randomized controlled trial - Eventscribe.com
Poster-abstract by Joseph M. Caporusso (McAllen, USA).
Dealing With Pain: An Approach to Chronic Pain Management in Wound Patients - Todayswoundclinic.com
Article by Caralin Schneider, Scott Stratman, Daniel Federman, and Hadar Lev-Tov. When patients present with chronic pain, it is crucial for wound clinicians to use a multifaceted approach to pain management. These authors address pain management techniques that include opioids, non-opioid pharmacologics, targeted interventional therapies, and complementary and alternative medicine.
Trending Non-Opioid Procedural Pain Management Options for Wound Providers - Todayswoundclinic.com
Article by Survam Patel. Chronic wound pain and procedural pain issues are well studied and documented, but novel, affordable procedural pain management options are lacking. This author discusses emerging wound-related pain management trends, including current procedural and operative pain management best practices for wound care providers.
Metabolic regulation of innate immune cell phenotypes during wound repair and regeneration - Nih.gov
Abstract by Ajoy Aloysius, Sandeep Saxena and Ashley W Seifert (Lexington, USA - Curr Opin Immunol.).
Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment - Nih.gov
Abstract by Mou Zhou, Fang Lin, Wendan Li, Linying Shi, Yanhui Li and Guiqiu Shan (Guangzhou, China - Int J Biol Macromol.).
Who Said Persistence Doesn’t Pay Off? FDA Closer to New Primary Wound Care Endpoints - Todayswoundclinic.com
Article by Peggy Dotson. The FDA has been presented the robust evidence to support 6 new primary wound care endpoints in clinical trials for approvals of new devices and drugs. This author details the new proposed endpoints and the collaborative approach that went into identifying them.
Mesenchymal Stem Cells Application in Wound Tissue Healing in Old Animals - Dovepress.com
Article by Ekaterina Silina, Natalia Manturova and Victor Stupin (Moscow, Russia - Stem Cells and Cloning: Advances and Applications).
The applications of MSC in various ways improve and accelerate wound healing even in old animals. The best performance was achieved in the Polymer_sc group.
Cuttlebone Fillers for Topical Hemorrhage and Wound Healing: In Vitro Insights and a Suppository Model - Researchsquare.com
Article by Alisa Palaveniene (Kaunas, Lithuania).
Based on the primal, though essential to conduct in vitro test results, application of cuttlebone fillers could open a new page in the development of successful naturally-based hemostatic and wound healing products.
Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway - Nih.gov
Abstract by Xiaolong Sun, Xu Wang, Zhenyu Zhao, Jing Chen, Cheng Li and Gang Zhao (Harbin, China - Acta Histochem.).
Association of Negative Pressure Wound Therapy and Dermatotraction for Management of Necrotizing Soft Tissue Infections: A Case Series - Nih.gov
Abstract by Daniel Aparicio-Sánchez, José Pintor-Tortolero, Eduardo Perea-Del Pozo, Luis Tallón-Aguilar and Francisco Javier Padillo-Ruiz (Seville, Spain - Wounds).
pdf (3,4 mB)!
Eicosanoids in Skin Wound Healing - Mdpi.com
Article by Ken Yasukawa, Toshiaki Okuno and Takehiko Yokomizo (Tokyo, Japan - International Journal of Molecular Sciences).
This review article highlights the roles of eicosanoids on skin wound healing, especially focusing on the biosynthetic pathways and biological functions, i.e., inflammation, proliferation, migration, angiogenesis, remodeling, and scarring.
Wound-healing biomaterials activate immune system for stronger skin - Phys.org
Researchers at Duke University and the University of California, Los Angeles, have developed a biomaterial that significantly reduces scar formation after wounding, leading to more effective skin healing. This new material, which quickly degrades once the wound has closed, demonstrates that activating an adaptive immune response can trigger regenerative wound healing, leaving behind stronger and healthier healed skin.
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing - Nature.com
Abstract by Donald R. Griffin, Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim V. Plikus, Dino Di Carlo, Tatiana Segura and Philip O. Scumpia.
Assessment and Interventions for Present-on-Admission Pressure Injuries - Woundsource.com
Pressure injuries are among the most significant health and patient safety issues that health care facilities face daily. Aside from the strong impact on patients’ quality of life, they also have high costs of treatment, not just to the patient, but also to the health care industry. The Agency for Healthcare Research and Quality reported $20,900 to $151,700 per individual patient and pressure injury in health care costs.
Biomimetic Alginate/Gelatin Cross-Linked Hydrogels Supplemented with Polyphosphate for Wound Healing Applications - Mdpi.com
Article by Shunfeng Wang, Xiaohong Wang, Meik Neufurth, Emad Tolba, Hadrian Schepler, Shichu Xiao, Heinz C. Schröder and Werner E. G. Müller (Germany, China - Molecules).
From these data, the authors conclude that polyP-containing alginate/oxidized-alginate-gelatin hydrogels may provide a suitable regeneratively active matrix for wound healing for potential in vivo applications.
Consistent practice for pressure ulcer prevention in long‐term older people care: A quasi‐experimental intervention study - Wiley.com
Abstract by Sirpa Mäki‐Turja‐Rostedt, Helena Leino‐Kilpi, Teija Korhonen, Tero Vahlberg and Elina Haavisto (Caring Sciences)
Improvement of the Wound Healing Properties of Hydrogels with N-acetylcysteine through their Modification with Methacrylate-Containing Polymers - Rsc.org
Abstract by Lesly S. Gomez-Aparicio, Johanna Bernáldez-Sarabia, Tanya Camacho Villegas, Pavel H. Lugo-Fabres, Néstor E. Díaz-Martínez, Ediardo Padilla-Camberos, Alexei Licea-Navarro and Ana B. Castro-Ceseña (Biomaterials Science).
Prophylactic negative-pressure wound therapy after ileostomy reversal for the prevention of wound healing complications in colorectal cancer patients: a randomized controlled trial - Springer.com
Article by M. Wierdak, M. Pisarska-Adamczyk, M. Wysocki, P. Major, K. Kołodziejska, M. Nowakowski, T. Vongsurbchart and M. Pędziwiatr (Krakow, Poland - Techniques in Coloproctology).
Prophylactic postoperative NPWT after diverting ileostomy closure in colorectal cancer patients reduces the incidence of WHC, SSI, and complete wound healing time.
Effective Scarless Wound Healing Mediated by Erbium Borate Nanoparticles - Nih.gov
Abstract by Oğuz Kaan Kırbaş, Batuhan Turhan Bozkurt, Pakize Neslihan Taşlı, Taha Bartu Hayal, İrem Özkan, Berna Bülbül, Seda Beyaz and Fikrettin Şahin (Turkey - Biol Trace Elem Res.).
Sodium alginate/collagen hydrogel loaded with human umbilical cord mesenchymal stem cells promotes wound healing and skin remodeling - Nih.gov
Abstract by Zhenkun Zhang, Zhe Li, Ya Li, Yingying Wang, Minghao Yao, Kun Zhang, Zhenyu Chen, Han Yue, Jijing Shi, Fangxia Guan and Shanshan Ma (Zhengzhou, China - Cell Tissue Res.).
The efficacy of gelatin sponge combined with moist wound-healing nursing intervention for the treatment of pressure ulcers: A randomized controlled trial protocol - Nih.gov
Abstract by Shun Huang, Ying Yang, Xiaoli Yu and Yonggang Wang (Beijing, China - Medicine (Baltimore)).
pdf (3,5 mB)!
Coconut Oil Nanoemulsion Loaded with a Statin Hypolipidemic Drug for Management of Burns: Formulation and In Vivo Evaluation - Mdpi.com
Article by Khaled M. Hosny, Nabil A. Alhakamy, Amal M. Sindi and Rasha A. Khallaf (Saudi Arabia, Egypt - Pharmaceutics).
In the current study, the Box–Behnken design was employed for the optimization of a coconut oil–based nanoemulsion loaded with SMV that was intended for the topical treatment of burn wounds. The developed nanoemulsions acquired an adequate droplet size of between 65 and 195 nm, indicating the formation of nanoemulsions. The statistical design proved the important synergistic effect of coconut oil and SMV for burn wound management. This combination potentiated the wound closure ability, anti-inflammatory properties, and antimicrobial effects of each of the components.
Effect of photobiomodulation therapy on the proliferation phase and wound healing in rats fed with an experimental hypoproteic diet - Nih.gov
Abstract by Eliane Martins Amadio, Rodrigo Labat Marcos, Andrey Jorge Serra, Solange Almeida Dos Santos, Jheniphe Rocha Caires, Guilherme Henrique Cardosos Fernandes, Ernesto Cesar Leal-Junior, João Carlos Correa Ferrari and Paulo de Tarso Camillo de Carvalho (São Paulo, Brazil - Lasers Med Sci.).
Contemporary Review to Reduce Groin Surgical Site Infections in Vascular Surgery - Nih.gov
Abstract by Haroon Rasheed, Kaled Diab, Tarundeep Singh, Yusuf Chauhan, Paul Haddad, M Mujeeb Zubair, Travis Vowels, Edward Androas, Manuel Rojo, Phillip Auyang, Ross McFall, Luis Felipe Gomez, Ahmed Mohamed, Eric Peden and Maham Rahimi (Houston, USA - Ann Vasc Surg.).
Pure Hypochlorous Acid: A Primer on pH and Wound Solutions - Woundsource.com
Article by Luis Fernandez. Complex wounds have plagued humankind for thousands of years, and the search for methods to combat infectious agents has been met with limited success. Although silver, iodine, and honey still hold a place in a long list of treatments employed today, in general, these and other antimicrobials have at least one thing in common: unlike pure hypochlorous acid (HOCL), none of them are native to humans (iodine is not present in humans in an antimicrobial role).
Preparation and characterization of poly(ethylene) oxide/zinc oxide nanofibrous scaffold for chronic wound healing applications - Nih.gov
Abstract by Hamed Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Morteza Alizadeh, Shiva Asadpour, Esmaeel Sharifi, Jafar Ai and Mostafa Soleimannejad (Iran - Polim Med.).
Effects of cefazolin-containing niosome nanoparticles against methicillin-resistant Staphylococcus aureus biofilm formed on chronic wounds - Nih.gov
Abstract by Mahdi Zafari, Mahsa Adibi, Mohsen Chiani, Negin Bolourchi, Seyed Mahmoud Barzi, Mohammad Sadegh Shams Nosrati, Zeinab Bahari, Parisa Shirvani, Kambiz Akbari Noghabi, Mojgan Ebadi, Nazanin Rahimirad and Morvarid Shafiei (Tehran, Iran - Biomed Mater.).
Unilateral lymphoedema of lower limb: an unusual presenting feature of hidden tuberculosis verrucosa cutis of foot - Nih.gov
Abstract by Maninder Kaur, Dinesh P Asati, Ujjawal Khurana and Suman Patra (Bhopal, India - BMJ Case Rep.).
β-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes - Mdpi.com
Article by Venkata Viswanadh Edara, Shruthi Nooka, Jessica Proulx, Satomi Stacy, Anuja Ghorpade and Kathleen Borgmann (USA - Biomedicines).
The authors's study demonstrates that HIV-associated inflammation increases β-catenin pathway mediators to augment activated astrocyte responses including migration and proliferation, while mitigating IL-6 expression. These findings suggest that β-catenin plays an anti-inflammatory role in activated human astrocytes during neuroinflammatory pathologies, such as HAND.
Conductive hydrogel composites with autonomous self-healing properties - Nih.gov
Abstract by Xiaohui Li, Xia Huang, Hatice Mutlu, Sharali Malik and Patrick Theato (Germany - Soft Matter.).
Effect of PDGF-B Gene-Activated Acellular Matrix and Mesenchymal Stem Cell Transplantation on Full Thickness Skin Burn Wound in Rat Model - Nih.gov
Abstract by Tamilmahan Paramasivam, Swapan Kumar Maiti, Sangeetha Palakkara, Rashmi, Divya Mohan, H V Manjunthaachar, K Karthik and Naveen Kumar (Izatnagar, India - Tissue Eng Regen Med.).
Negative Pressure Wound Therapy (NPWT) in Groin Wounds After Lymphadenectomy in Vulvar Cancer Patients - Nih.gov
Abstract by Katrin Christine Asciutto, Stefan Acosta and Christer Borgfeldt (Sweden - In Vivo).
Efficacy of Cultured Allogenic Keratinocytes in Treatment of Deep Second-Degree Burn - Nih.gov
Abstract by Eung Hyun Kim and Soo Hyang Lee (Goyang-si, South Korea - J Burn Care Res.).
Pressure Injury Prevention While Proning - Woundsource.com
The coronavirus disease 2019 (COVID-19) pandemic has forced health care professionals to take a closer look at the most effective and appropriate measures for pressure injury prevention. In 17% of all COVID-19 cases, pneumonia secondary to acute respiratory distress syndrome is the most common complication; therefore, prone positioning is used as an adjuvant therapy.
Jenny Lopez: Adipose Tissue Extract improves wound healing - Tuni.fi
Adipose tissue extract (ATE), an acellular bioactive substance has previously shown angiogenic and adipogenic potential due to its growth factor-rich content. A new operating room preparation method of this extract was discovered. Also, the in vitro and clinical effects of ATE were investigated in the doctoral dissertation of M.D. Jenny Lopez.
UST researchers develop wound-healing hydrogels from sustainable marine-food wastes - Ust.edu.ph
Shifting from waste reduction to waste utilization, the University of Santo Tomas College of Science faculty members and researchers Asst. Prof. Jolleen Natalie I. Balitaan and Prof. Karen S. Santiago, Ph.D., recently developed self-healing injectable hydrogels for wound healing application. They synthesized ‘modified β-chitin’ from a marine bio-waste product, squid pens, and fabricated acrylamide-modified β-chitin/alginate dialdehyde, which can be used for accelerated healing of wounds.
Inhibition of exosomal miR-24-3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3 - Nih.gov
Abstract by Yan Xu, Liu Ouyang, Lei He, Yanzhen Qu, Yu Han and Deyu Duan (China - J Cell Mol Med.).
Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing - Mdpi.com
Article by Dorota Kowalczuk, Małgorzata Miazga-Karska, Agata Gładysz, Paweł Warda, Agnieszka Barańska and Bartłomiej Drop (Lublin, Poland - Molecules).
The newly developed dressings show activity against tested reference and clinical Gram-positive and Gram-negative strains. Yet, in order to evaluate their potential application in practice, further research into this issue should focus on their safety and efficacy. It should be noted that there is insufficient evidence as yet to confirm the effect of antimicrobial dressings on wound healing in clinical practice.
Fucoidan demonstrates wound healing benefits - Nutraceuticalbusinessreview.com
An Australian study examining polyelectrolyte multilayers (PEMs) has strengthened the case for fucoidan as a candidate for the development of materials for use in the medical device sector.
Therapeutic efficacy of the developed gel "Xeliogel" on a burn wound model in rats - Nih.gov
Abstract by Bohdana Pavliuk, Iryna Stechyshyn, Solomiia Kramar, Mariana Chubka and Taras Hroshovyi (Ternopil, Ukraine - Pol Merkur Lekarski.).
Prevalence of pressure ulcers in africa: A systematic review and meta-analysis - Nih.gov
Abstract by Denis Anthony, Dalyal Alosaimi, Wondimeneh Shibabaw Shiferaw, Kwadwo Korsah and Reza Safari (UK, Saudi Arabia, Ethiopia, Ghana - J Tissue Viability).
Pressure Injury Prevention Considerations for Older Adults - Nih.gov
Abstract by Linda Cowan, Vianna Broderick and Jenny G Alderden (USA - Crit Care Nurs Clin North Am.).
Therapeutic strategies for enhancing angiogenesis in wound healing - Website60s.com
Article by Austin P. Veith, Kayla Henderson, Adrianne Spencer, Andrew D. Sligar and Aaron B. Baker (Austin, USA).
Heparin MicroIslands to Promote Enhanced Diabetic Wound Healing Outcomes - Biorxiv.org
Article by Lauren Pruett, Christian Jenkins, Neharika Singh, Katarina Catallo and Donald Griffin (Charlottesville, USA).
The authors incorporated heparin microislands within microporous annealed particle (MAP) scaffolds, which allows them to tune their incorporation ratiometrically to create a heterogenous microenvironment. In this
manuscript, the authors demonstrate the ability of heparin microislands to organize uniform growth factors into spontaneous microgradients and control downstream cell migration in vitro.
A retrospective case series of Fournier's gangrene: necrotizing fasciitis in perineum and perianal region - Nih.gov
Abstract by Nan Zhang, Xin Yu, Kai Zhang and Tongjun Liu (Changchun, China - BMC Surg.).
A novel hydrogel with self-healing property and bactericidal activity - Nih.gov
Abstract by Yuxuan Wu, Jihui Wang, Lin Li, Xu Fei, Longquan Xu, Yi Wang, Jing Tian and Yao Li (China - J Colloid Interface Sci.).
pdf (1,5 mB)!
From Grafts to Human Bioengineered Vascularized Skin Substitutes - Mdpi.com
Article by Wasima Oualla-Bachiri, Ana Fernández-González, María I. Quiñones-Vico and Salvador Arias-Santiago (Spain, International Journal of Molecular Sciences).
The aim of this review is to outline the recent advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing.
Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors - Nih.gov
Abstract by Mahnaz Mohtashami, Mahsa Mohamadi, Mohsen Saiedi, Jafar Saiedi, Fatemeh Forooghi Nia and Ahmad Ghasemi (Iran, France - Biotechnol Appl Biochem.).
Extracellular vesicles and the extracellular matrix: a new paradigm or old news? - Nih.gov
Abstract by Samuel Lewin, Stuart Hunt and Daniel W Lambert (Sheffield, UK - Biochem Soc Trans.).
Comparison of the efficacy of topical hyperbaric oxygen therapy alone versus a combination of physical methods including topical hyperbaric oxygen therapy, magnetotherapy and low-energy light therapy in the treatment of venous leg ulcers - Nih.gov
Abstract by Jarosław Pasek, Sebastian Szajkowski, Mikołaj Pietrzak and Grzegorz CieŚlar (Poland - Dermatol Ther.).
Finite Element Analysis Modeling of a Novel Silicone Dressing - Nih.gov
Abstract by James Sieracki, Robert Wilkes, Eric R Bennett and Amy K McNulty (USA - Cureus).
Update review on five top clinical applications of human amniotic membrane in regenerative medicine - Nih.gov
Abstract by Aida Rezaei Nejad, Amir Ali Hamidieh, Mohammad Amir Amirkhani and Mahsa Mollapour Sisakht (Iran, The Netherlands - Placenta).
Hyperbaric oxygen therapy - Nih.gov
Abstract by Ole Hyldegaard and Morten Hedetoft (Denmark - Ugeskr Laeger.).
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