The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats - Dovepress.com
Article by Victor Stupin, Natalia Manturova, Ekaterina Silina, Petr Litvitskiy, Vitaly Vasin, Elena Artyushkova, Alexander Ivanov, Mikhail Gladchenko and Salekh Aliev (Russia - Journal of Experimental Pharmacology).
The severity and duration of the inflammation process during wound healing were ambiguous with the use of different injection treatments. This should compel clinicians to use different markers of drug therapy effectiveness during wound healing. Excessive leukocyte infiltration with a low temperature of wounds and a large scab were markers of delayed wound healing.
Long-Term Care: Skin Assessment Observation - Woundsource.com
Article by Susan Cleveland. The subject of her previous blog on skin assessment was interview; here in part 2, we will look at the elements of observation. Interviewing clients and significant others can provide the clinician with valuable information related to the client’s knowledge of their situation and a historic review of skin issues or potential events. However, observation is also necessary in a comprehensive skin assessment.
Fistula Management: Frequently Asked Questions - Woundsource.com
Article by Dianne Rudolph. What are some ways to achieve insurance coverage for fistula pouches or to use ostomy supplies for a fistula? Does NPWT help with closing or collapsing the fistula? When cleaning a wound, what is the appropriate action for cleaning the fistula?
Delayed Wound Healing Due to Gene Mutations - Technologynetworks.com
Scientists at Fujita Health University, Japan, have discovered how deficiencies of the IL-36Ra protein—caused by mutations in the IL36RN gene—delay wound healing via the flooding of the wound with several types of immune cells. However, by inhibiting the functioning of proteins and the signaling pathways involved in activating the immune system at a wound, this delay can be offset. These findings could aid efforts to develop ways of regulating wound healing in IL36RN mutation-related skin disorders.
A Systematic Overview of Recent Methods for Non-Contact Chronic Wound Analysis - Mdpi.com
Article by Domagoj Marijanović and Damir Filko (Osijek, Croatia - Applied Sciences).
The aim of this paper is to provide an overview of recent methods for non-contact wound analysis which could be used for developing an end-to-end solution for a fully automated wound analysis system which would incorporate all stages from data acquisition, to segmentation and classification, ending with measurement and healing evaluation.
Effects of smoking on the wound healing of stage 4 pressure ulcers in rats - Nih.gov
Abstract by M Y Song, X Li, S S Liu, Y Wang, Z H Zhao, Y Wang and Z Y Chen (Shijiazhuang, China - Zhonghua Shao Shang Za Zhi).
In vivo drug delivery applications of nanogels: a review - Nih.gov
Abstract by Filippo Pinelli, Óscar Fullana Ortolà, Pooyan Makvandi, Giuseppe Perale and Filippo Rossi (Italy, Iran, Switzerland - Nanomedicine (Lond.)).
Anti-inflammatory mediator may play key role in wound healing - Medical.net
One critical step in wound healing is the infiltration of inflammatory cells into the vicinity of a wound in the "cleaning out" phase. But this is something of a double-edged sword: either excessive or inadequate infiltration can delay wound healing.
Graphene Oxide/Copper Nanoderivatives-Modified Chitosan/Hyaluronic Acid Dressings for Facilitating Wound Healing in Infected Full-Thickness Skin Defects - Dovepress.com
Article by Ying Yang, Zhonggen Dong, Min Li, Lihong Liu, Hang Luo, Pu Wang, Dou Zhang, Xinghua Yang, Kechao Zhou and Shaorong Lei (Changsha, China - International Journal of Nanomedicine).
GO/Cu-incorporated chitosan/hyaluronic acid dressings suggested a synergistic antimicrobial efficacy and acceptable biocompatibility both in vitro and in vivo, as well as a significantly accelerated healing process of bacteria-infected wounds.
Timing and Management of Surgical Site Infections in Patients with Open Fracture Wounds: A Fluid Lavage of Open Wounds (FLOW) Cohort Secondary Analysis - Nih.gov
Abstract by Carlos Prada, Francesc A Marcano-Fernández, Emil H Schemitsch, Sofia Bzovsky, Kyle Jeray, Brad Petrisor, Mohit Bhandari and Sheila Sprague (Canada, Spain, USA - J Orthop Trauma.).
Value of Indocyanine Green Angiography to Guide Wound Management and Prevent Necrosis in a Robotic Surgical Procedure - Nih.gov
Abstract by Danny Lam, Rahul Rindani, Scott Leslie, Sanjay Warrier and Nariman Ahmadi (Australia - J Endourol Case Rep.).
Use of Reticulated Open Cell Foam Dressings With Through Holes During Negative Pressure Wound Therapy With Instillation and Dwell Time: A Large Case Study - Oup.com
Article by Luis G Fernández, Marc R. Matthews, Cynthia Ellman, Patricia Jackson, David H. Villarreal and Scott Norwood (USA, Wounds). In the authors’ clinical practice, NPWTi-d with ROCF-CC provided effective removal of thick exudate and promoted a more rapid development of underlying granulation tissue.
Visualization of Wound Healing Progression With Near Infrared Spectroscopy: A Retrospective Study - Oup.com
Article by Adam Landsman (Boston, USA). As with any imaging technology, both qualitative and quantitative data are used to determine what is happening clinically. This study represents an early attempt to understand the role of NIRS and percent oxygenated hemoglobin in the wound healing process. It also lays the groundwork for identifying patterns associated with wound closure.
Wound healing center establishment and new technology application in improving the wound healing quality in China - Oup.com
Article by Xiaobing Fu (Burns & Trauma). In this paper, the main achievements in wound healing, tissue repair and regeneration in China are reviewed and the establishment of wound healing centers and new technology application in improving wound healing quality in patients in China is highlighted.
A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration - Wiley.com
Article by Zainab Ahmadian, Alexandra Correia, Masoud Hasany, Patrícia Figueiredo, Faramarz Dobakhti, Mohammad Reza Eskandari, Seyed Hojjat Hosseini, Ramin Abiri Shiva Khorshid, Jouni Hirvonen, Hélder A. Santos and Mohammad‐Ali Shahbazi.
A radical scavenging, hemostatic, antibacterial, and ECM‐mimicking bioactive hydrogel was developed. It was shown that similar to polydopamine, TA can improve the mechanical property of gelatin‐based hydrogels through noncovalent hydrogen bonding. Moreover, very rapid gel formation, and high capacity of the GelTA for drug loading and delivery was achieved.
Foot ulcer recurrence, plantar pressure and footwear adherence in people with diabetes and Charcot midfoot deformity: a cohort analysis - Nih.gov
Abstract by R Keukenkamp, T E Busch-Westbroek, R Barn, J Woodburn and S A Bus (The Netherlands, UK - Diabet Med.).
Factors affecting length of stay in Fournier's gangrene: a retrospective analysis of 10 years' data - Nih.gov
Abstract by Mithat Eksi, Yusuf Arikan, Abdulmuttalip Simsek, Osman Ozdemir, Serdar Karadag, Necati Gurbuz, Selcuk Sahin and Ali Ihsan Tasci (Istanbul, Turkey - Aktuelle Urol.).
Topical Antibiotic Ointment’s Place in Wound Care - Woundcarelearningnetwork.com
Article by Laura Swoboda. Topical antibiotics do have their place, mainly in the prophylaxis of infection in superficial burns and minor trauma. There are two main reasons the author try to avoid the use of antibiotic ointments unless clearly indicated: antimicrobial stewardship and skin sensitivity, or allergenicity.
Cost Effectiveness of Fish Skin Grafts Versus Standard of Care on Wound Healing of Chronic Diabetic Foot Ulcers: A Retrospective Comparative Cohort Study - Woundresearch.com
Article by Christopher Winters, Robert S. Kirsner, David J. Margolis and John C. Lantis II. The cost simulation performed in this study found that fish skin is both more cost effective and more clinically effective than SOC alone in treating chronic DFUs. The advantage of using a simulation model such as the Markov model is that it is easy to update with new data, either when more data are available in the United States for comparing cost effectiveness in other countries, or to compare fish skin with other advanced wound therapies; future studies should focus on this.
Diabetic Foot Infection and Select Comorbidities Drive Readmissions in Outpatient Parenteral Antimicrobial Therapy - Nih.gov
Abstract by Andrew Barnes and Marina Nunez (Winston Salem, USA - Am J Med Sci.).
Comparison of Dietary Oils with Different Polyunsaturated Fatty Acid n-3 and n-6 Content in the Rat Model of Cutaneous Wound Healing - Mdpi.com
Article by Tomas Komprda, Zbysek Sladek, Zuzana Sevcikova, Veronika Svehlova, Jan Wijacki, Roman Guran, Tomas Do, Zuzana Lackova, Hana Polanska, Lucie Vrlikova, Vendula Popelkova, Petr Michalek, Ondrej Zitka and Marcela Buchtova (Brno, Czech Republic - IJMS).
The authors' study confirmed that wound healing processes in skin are modulated by the content of supplementary oils in diets. Dietary oil containing high PUFA n-6 caused delay of healing processes including wound closure and enhanced angiogenesis.
Adenosine diphosphate contributes to wound healing in diabetic mice through P2Y1 and P2Y12 receptors activation - Biorxiv.org
Article by Paula A. Borges, Ingrid Waclawiak, Janaína L. Georgii, Janaína F. Barros, Vanderlei S. Fraga-Junior, Felipe S. Lemos, Thaís Russo-Abrahão,
Elvira M. Saraiva, Christina M. Takiya, Robson Coutinho-Silva, Carmen Penido, Claudia Mermelstein, José R. Meyer-Fernandes,
Fábio B. Canto, Josiane S. Neves, Paulo A. Melo, Claudio Canetti and Claudia F. Benjamim (Rio de Janeiro, Brazil).
The authors for the first time demonstrated, that ADP promotes skin homeostasis by inducing a brief and balanced inflammatory and immune response, followed by an adequate proliferative and remodeling phase, results summarized in the cartoon. Thus, exogenous ADP could be a new insight for therapeutic agents in diabetic wounds.
Dehydrated Human Amnion Chorion Membrane as Treatment for Pediatric Burns - Nih.gov
Abstract by Natasha Ahuja, Richard Jin, Colin Powers, Alexandria Billi and Kathryn Bass (Buffalo, USA - Adv Wound Care (New Rochelle)).
Protease-Resistant Growth Factor Formulations for the Healing of Chronic Wounds - Nih.gov
Abstract by Tabitha Boeringer, Lisa J Gould and Piyush Koria (USA - Adv Wound Care (New Rochelle)).
Bioburden Management in Surgical Wounds - Woundsource.com
Surgical site infections (SSIs) are a risk for the more than 10 million patients who undergo inpatient surgical procedures every year in the United States. Between 300,000 and 500,000 Americans develop SSIs annually. SSIs are defined as infections related to an operative procedure that occur at or near the surgical incision within 30 days of the procedure, or within 90 days if prosthetic material is implanted.
Accurately Identifying Wound Etiology by Tissue Type and Appearance - Woundsource.com
Article by Holly Hovan. Identifying wound etiology before initiating topical treatment is important. Additionally, correctly documenting wound etiology is significant in health care settings for many reasons. Accurate documentation and appropriate topical treatment are two critical components of a strong wound treatment plan and program.
Novel application of autologous micrografts in a collagen-glycosaminoglycan scaffold for diabetic wound healing - Nih.gov
Abstract by Adriana C Panayi, Valentin Haug, Qinxin Liu, Mengfan Wu, Mehran Karvar, Shimpo Aoki, Chenhao Ma, Ryoko Hamaguchi, Yori Endo and Dennis P Orgill (Boston, USA - Biomed Mater.).
The effect of limb position on the reliability of leg circumference measurements in patients diagnosed with lower limb lymphoedema - Nih.gov
Abstract by R Scheer, E Crofton and N Andrews (Australia - Support Care Cancer).
How to create negative pressure wound dressing with wall suction: novel treatment of subcutaneous emphysema with PICO dressing - Nih.gov
Abstract by Minesh Prakash and Felicity Meikle (Hamilton, New Zealand - ANZ J Surg.).
Avoiding Malpractice Claims With Better Communication Among Physicians - Todayswoundclinic.com
Article by Laura Hale Brockway. Effective communication among wound care physicians is crucial to prevent malpractice claims. This author presents a case study illustrating how action or inaction on the part of the physicians led to allegations of professional liability, and how risk management techniques may have either prevented the outcome or increased the physician’s defensibility.
Pressure Injuries: What to Do When Surgery Fails - Generalsurgerynews.com
Article by Chase Doyle. Advanced-stage pressure injuries, or pressure ulcers, are a difficult and increasingly common problem whose challenges persist long after the completion of surgery. Meticulous postoperative care and timely management of complications are critical to a successful outcome.
Bedside Technologies to Enhance the Early Detection of Pressure Injuries: A Systematic Review - Nih.gov
Abstract by Katherine N Scafide, Mary Curry Narayan and Linda Arundel (Fairfax, USA - J Wound Ostomy Continence Nurs.).
Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds - Nih.gov
Abstract by Ann Hui Ching, Nicole Le, Amanda Norwich-Cavanaugh and Henry C Hsia (New Haven, USA - Ann Plast Surg.).
Surgical Site Management: Choosing an Antimicrobial Dressing - Woundsource.com
Surgical site management in the post-operative time frame is paramount in preventing infection and wound dehiscence. It is essential to use practical knowledge in good wound cleansing and skin care and in providing moisture balance in surgical site wound care management.
What Are the Categories of Wound Closure? - Medicinenet.com
Article by Jasmine Shaikh. An open wound can be closed in any of the three ways. These ways are referred to as the three categories of wound closure or three ways of wound healing. These are as follows...
Wound healing, antimicrobial and antioxidant properties of the leaf and stem bark of Entada africana Guill. & Perr. - Sciencedirect.com
Article by Michael Frimpong Baidoo, Abraham Yeboah Mensah, Paul Poku Sampene Ossei, Evelyn Asante-Kwatia and Isaac Kingsley Amponsaha (Kumasi, Ghana - South African Journal of Botany).
This study has given scientific credence to the folkloric use of the leaves and stem bark of Entada africana as wound healing agents. Though the specific wound healing compounds and mechanisms of action are yet to be established, the current results clearly provide the first evidence that topical application of E. africana on skin lesions accelerates wound healing.
Australian scientists win global NASA competition with revolutionary wound healing technology - Miragenews.com
Ground-breaking Australian wound-healing technology will be catapulted into space to treat astronauts, following the unprecedented win by Southern Cross University scientists at NASA’s global iTech competition.
Wound healing properties of magnesium mineralized antimicrobial nanofibre dressings containing chondroitin sulphate – a comparison between blend and core–shell nanofibres - Rsc.org
Abstract by Chak Ming Leung, Chetna Dhand, Venkatesh Mayandi, Raghavendra Ramalingam, Fui Ping Lim, Veluchamy Amutha Barathi, Neeraj Dwivedi, Gorka Orive, Roger W. Beuerman, Seeram Ramakrishna, Yi-Chin Toh, Xian Jun Loh, Navin Kumar Verma, Alvin Wen Choong Chua and Rajamani Lakshminarayanan (Singapore, India, Spain, Australia - Biomaterials Science).
Effectiveness of negative pressure wound therapy in the prevention of surgical wound complications in the cesarean section at-risk population: a parallel group randomised multicentre trial - the CYGNUS protocol - Bmj.com
Article by Kylie Sandy-Hodgetts, Richard Parsons, Richard Norman, Mark W Fear, Fiona M Wood and Scott W White (Australia, BMJ Open).
The CYGNUS trial is a designed as a multicentre randomised control trial that is powered to determine treatment effectiveness. This robust study design has been engaged to ensure that any differences between the two arms of the study are attributable to the intervention.
When Should You Not Close A Wound? - Medicinenet.com
Article by Divya Jacob. Wounds should not be closed in the following conditions: Wounds with high chances of infection should be kept open for greater than 24 hours or should not be stitched for adequate cleaning and antibiotic treatment to prevent the risk of infection...
Nonpharmacological Management of Diabetic Foot Ulcers: An Update - Nih.gov
Abstract by Ioanna Eleftheriadou, Georgia Samakidou, Anastasios Tentolouris, Nikolaos Papanas and Nikolaos Tentolouris (Greece - Int J Low Extrem Wounds).
Failure of Healing in Chronic Diabetic Wounds: A Case Report - Nih.gov
Abstract by James B Stiehl (Chicago, USA - Adv Skin Wound Care).
A Novel Use of Next-Generation Closed Incision Negative Pressure Wound Therapy After Major Limb Amputation and Amputation Revision - Nih.gov
Abstract by Julie West, Julia Wetherhold, Steven Schulz and Ian Valerio (USA - Cureus).
Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing - Mdpi.com
Article by Francis Kamau Mwiiri and Rolf Daniels (Tuebingen, Germany - Molecules).
This study broadens the knowledge on PVA-based electrospun fibers with a colloidal dispersion of a birch bark extract as the active principle for enhanced wound healing. The concentration and
molecular weight of the polymer as the most decisive parameters have a significant effect on the rheological properties of the polymer solution and affect directly the resulting fiber properties.
Natural Film Based on Pectin and Allantoin for Wound Healing: Obtaining, Characterization, and Rat Model - Hindawi.com
Article by Karen Zulema Meza Valle, Rosa A. Saucedo Acuña, Judith V. Ríos Arana, Naun Lobo, Carlos Rodriguez, Juan Carlos Cuevas-Gonzalez and Karla Lizette Tovar-Carrillo (Juárez, Mexico - BioMed Research International).
In vivo assay results showed remarkable reduction of wound area by using PA hydrogel from day 4 and the complete healing process at day 18. PA hydrogel reduces the total healing time by 25% approximately. These results indicated that PA hydrogel films could become the leading biomaterial candidates for wound healing treatments.
Malignant Degeneration of Scars - Dovepress.com
Article by Anca E Chiriac, Mircea Betiu, Piotr Brzezinski, Beatriz Di Martino Ortiz, Anca Chiriac, Liliana Foia and Doina Azoicai (Romania, Paraguay, Poland - Cancer Management and Research).
Malignant degeneration of scarring tissue should be the main concern for patients and for their healthcare monitors. Any type of suspicious wound changes should be monitored and the lesion should be immediately biopsied. If malignancy is confirmed by histologic examination, staging and treatment are of outmost importance.
Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery - Wiley.com
Abstract by Fabio Rizzo and Nermin Seda Kehr (Advanced Healthcare Materials).
Nanoscale Particle Therapies for Wounds and Ulcers - Medscape.com
Article by Roberta Cortivo, Vincenzo Vindigni, Laura Iacobellis, Giovanni Abatangelo, Paolo Pinton and Barbara Zavan (Nanomedicine).
The last step of normal acute wound healing is remodeling, during which ECM components are modified by the balanced mechanisms of proteolysis and new matrix secretion, and during which the wound becomes gradually less vascularized. The initial granulation tissue is weak but gains strength over time due to the gradual replacement of immature type III collagen with mature type I collagen.
Octopus-inspired sucker transfers thin, delicate tissue grafts and biosensors - Sciencedaily.com
Thin tissue grafts and flexible electronics have a host of applications for wound healing, regenerative medicine and biosensing. A new device inspired by an octopus's sucker rapidly transfers delicate tissue or electronic sheets to the patient, overcoming a key barrier to clinical application.
Effects of injectable platelet-rich fibrin in experimental periodontitis in rats - Springer.com
Abstract by Hacer Sahin Aydinyurt, Tunahan Sancak, Cem Taskin, Yildiray Basbugan and Levent Akinci (Odontology).
Calciphylaxis: Diagnostic and Treatment Advances for the Inpatient Dermatologist - Springer.com
Abstract by Gowri Kabbur and Daniel D. Miller (Current Dermatology Reports).
Stasis Mucinosis: Insights Into Euthyroid Localized Mucinosis - Woundresearch.com
Article by Penelope A. Hirt, Flor E. MacQuhae, Jeong Hee Cho-Vega and Robert S. Kirsner (Miami, USA - Wounds). Stasis mucinosis and OALM have been described as 2 diagnostic entities; however, the authors believe it may be the same etiology caused by shared pathophysiological mechanisms. Dermal mucinosis needs extensive evaluation, including thyroid diseases. It is also important to remember that it can occur in the setting of obesity, lymphedema, and/or venous insufficiency.
Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Wounds - Woundresearch.com
Article by Matthew J. Regulski and Matthew R. MacEwan (USA - Wounds). The implantable nanomedical scaffold is an effective alternative to existing wound matrices capable of supporting the natural wound healing process. Most wounds were healed after 12 weeks with regular debridement and application of the implantable nanomedical scaffold. This implantable nanomedical scaffold may provide significant benefits as part of the treatment algorithm for challenging chronic wounds.
Dexamethasone Improves Wound Healing by Decreased Inflammation and Increased Vasculogenesis in Mouse Skin Frostbite Model - Wemjournal.org
Article by Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Michael C. Wadman, Robert L. Muelleman and Yu-Long Li (Nebraska, USA - Wilderness & Environmental Medicine).
Using a mouse frostbite model, we demonstrated that dex improved wound healing of frostbitten skin. In addition to anti-inflammatory effects, dex treatment increased collagen deposition and stimulated vasculogenesis. These findings suggest that the use of potent anti-inflammatory agents may be an effective strategy for mitigating frostbite injury.
Peripheral Calibrated Gradient Compression Pump for Treatment of Chronic Venous Leg Ulcers - Woundcarelearningnetwork.com
Abstract by Munir Patel, Scott Ellis, Emily Pesek, Jani Lee, Brooke Weiss and John Lantis.
Cadexomer Iodine Vs Silver Dressings In Exuding Wounds: Review - Medicaldialogues.in
Article by Dr. Kamal Kant Kohli. Cutaneous wound healing is an intricate and complex process of highly regulated factors that work to restore injured tissue towards repair and maintain the barrier function of the skin. When this healing process is disturbed and does not progress normally, due to an interplay of various factors, chronic wound results. Wound healing has received a lot of attention from the basic science behind it and the financial burden it causes.
Nutraceutical intervention towards wound healing after cancer surgery - Pninews.com
Wound healing, substitution of destroyed or damaged tissue by newly produced one, can classically be divided into four steps: haemostasis, inflammation, cell proliferation and tissue maturation. With each successive phase in the normal sequence of wound healing, the immune system orchestrates a wide variety of processes.
Surprising toxin discovery paves way for skin inflammation treatments - Nih.gov
Article by Brittany A. Roston. The toxins produced by an infection of a typically harmless bacteria called Staphylococcus aureus have been found to trigger wound healing, researchers have announced. The findings were surprising in light of what a ‘staph’ infection does to tissues, causing inflammation, boils, cellulitis, and more.
In-depth characterization of antibacterial activity of melittin against Staphylococcus aureus and use in a model of non-surgical MRSA-infected skin wounds - Nih.gov
Abstract by William Gustavo Lima, Júlio César Moreira de Brito, Valbert Nascimento Cardoso and Simone Odília Antunes Fernandes (Belo Horizonte, Brasil - Eur J Pharm Sci.).
Preparation of stretchable composite film and its application in skin burn repair - Nih.gov
Abstract by Li-Ping Wang, Hua-Jie Wang, Xue-Song Hou, Ali Raza, Yoshiyuki Koyama, Tomoko Ito and Jin-Ye Wang (China, Japan - J Mech Behav Biomed Mater.).
In-depth characterization of antibacterial activity of melittin against Staphylococcus aureus and use in a model of non-surgical MRSA-infected skin wounds - Nih.gov
Abstract by William Gustavo Lima, Júlio César Moreira de Brito, Valbert Nascimento Cardoso and Simone Odília Antunes Fernandes (Belo Horizonte, Brasil - Eur J Pharm Sci.).
Biofilms in Diabetic Foot Ulcers: Significance and Clinical Relevance - Mdpi.com
Article by Cassandra Pouget, Catherine Dunyach-Remy, Alix Pantel, Sophie Schuldiner, Albert Sotto and Jean-Philippe Lavigne (Nimes, France - Microorganisms).
Biofilms have a crucial role in DFIs and contribute to delayed healing. These wounds are characterized by a complex microbiome and a polymicrobial organization, especially within the biofilm. Even if most experimental biofilm studies provide descriptive and interesting information, they are derived from in vitro studies or non-adapted in vivo models.
Diamond-studded silk wound dressing detects infection and improves healing - Medicalexpress.com
In research led by RMIT University's Dr. Asma Khalid, smart wound dressings made of silk and nanodiamonds effectively sensed wound temperature, an early sign of infection, promoted healing and reduced infection from certain bacteria.
Outcomes of Negative Pressure Wound Therapies in the Management of Spine Surgical Site Wound Infections - Nih.gov
Abstract by Swamy Kurra, Aymen Rashid, Henaku Yirenkyi, Patrick Castle and William F Lavelle (Stockbridge, USA - Int J Spine Surg.).
Cost-effectiveness analysis of negative pressure wound therapy dressings after open inguinal vascular surgery - The randomised INVIPS-Trial - Nih.gov
Abstract by Robert Svensson-Björk, Sanjib Saha, Stefan Acosta, Ulf-G Gerdtham, Julien Hasselmann, Giuseppe Asciutto and Moncef Zarrouk (Sweden, Germany - J Tissue Viability).
Impact of wound duration on diabetic foot ulcer healing: evaluation of a new sucrose octasulfate wound dressing - Magonlinelibrary.com
Abstract by Ralf Lobmann, Arthur Grünerbel, Holger Lawall, Claas Lüdemann, Stephan Morbach, Wolfgang Tigges, Lukas Völkel and Reinhard PT Rychlik (Journal of Wound Care)
Photo-Optical Transcutaneous Oxygen Tension Measurement Is of Added Value to Predict Diabetic Foot Ulcer Healing: An Observational Study - Mdpi.com
Article by Bernard Leenstra, Robert de Kleijn, Geoffrey Kuppens, Bart Arnoldus Nicolaas Verhoeven, Jan Willem Hinnen and Gert J. de Borst (The Netherlands - JCM).
Photo-optical transcutaneous oxygen tension measurement is of added value to predict diabetic foot ulcer healing. However, to determine diabetic foot ulcer healing prognosis, the application of photo-optical TCpO2 alone is insufficient. Photo-optical TCpO2 does provide objective guidance which can aid in DFU treatment strategy and therefore should be adopted in wound classification systems.
Medicinal Effect, In Silico Bioactivity Prediction, and Pharmaceutical Formulation of Ageratum conyzoides L.: A Review - Hindawi.com
Article by Jasvidianto C. Kotta, Agatha B. S. Lestari, Damiana S. Candrasari and Maywan Hariono (Depok, Indonesia).
In Africa, goat weed has been used traditionally to relieve constipation and fever and applied as a wound dressing agent as well as an antiulcer agent. In Togo, this herb is used to treat measles and snake bite, whereas in Nigeria, it is used for skin diseases, wound healing, diarrhoea, pain around the navel in children, and even used to treat HIV/AIDS.
Experience with use of improvised negative pressure wound therapy in the management of wounds with exposed bone - Nih.gov
Abstract by Uwakwe C Mba and Wilfred O Okenwa (Enugu, Nigeria - Trop Doct.).
Role of Antioxidants in Wound Healing - Pharmaresearchlibrary.com
Abstract by Gupta Sushma, Kumar Ashish, Mazumder Avijit, Chakraborthy G.S and Das Saumya (Greater Noida, India).
β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte - Mdpi.com
Article by Esam Bashir Yahya, Marwa Mohammed Alzalouk, Khalifa A. Alfallous and Abdullah F. Abogmaza (South-Korea, USA - Molecules).
The authors's studies reveal that β-NEP plays an important role in the regulation of wound repair and suggest a therapeutic strategy to promote wound healing using β-NEP.
Antibacterial cellulose-based aerogels for wound healing application: A review - Mdpi.com
Article by Dong Joo Yang, Sang Hyun Moh, Yun-Hee Choi and Ki Woo Kim (The Vietnamese Journal of Medicine).
This review discussed some applications of using cellulose-based aerogels as an antibacterial carrier, and highlighted the concerns about the possible biological effects of these materials. There is a need for more animal-based long-term studies on cellulose aerogels to eliminate concerns and ensure safety of their use in humans.
Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization - Biologists.org
Abstract by Peilang Yang, Xiqiao Wang, Di Wang, Yan Shi, Meng Zhang, Tianyi Yu, Dan Liu, Min Gao, Xiong Zhang and Yan Liu (Shanghai, China - Journal of Cell Science).
EWMA Grant for Innovative DFU Projects - Ewma.org
EWMA and Urgo Medical are partnering this year to support two grants available to healthcare professionals working in diabetic foot care worldwide. The goal of this initiative is to offer support to innovative projects to improve diabetic foot ulcer prevention and management. Deadline: 20 December, 2020.
pdf (4,08 mB)!
Type II Collagen from Cartilage of Acipenser baerii Promotes Wound Healing in Human Dermal Fibroblasts and in Mouse Skin - Mdpi.com
Article by Ching-Shu Lai, Chun-Wei Tu, Hsing-Chun Kuo, Pei-Pei Sun and Mei-Ling Tsai (Taiwan - Marine Drugs).
The authors' results demonstrated the potential effect of SCC, the type II collagen derived from the cartilage of Acipenser baerii, on fibroblast proliferation, migration, and invasion, as well as on ECM synthesis. Additionally, SCC application accelerated wound healing in the mouse skin, demonstrating a cell type-specific target compared to TSC.
CDC recognises and codifies critical limb-threatening ischaemia in ICD-10-CM - Iwoundnews.com
A coalition organised by the CLI Global Society has announced its proposal to distinctly recognise “critical limb ischaemia” (CLI) and “chronic limb-threatening ischaemia” (CLTI) in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) was approved by the Centers for Disease Control and Prevention (CDC) and went into effect on 1 October 2020.
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study - Nih.gov
Abstract by Sonia O Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J Brett, Silvia Calvino-Gunther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy François, Patrick M Honore, Radmilo Jankovic, Ashish K Khanna, Mireia Llaurado-Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn I Blot and DecubICUs Study Team; European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators (Belgium, UK, Israel, Australia, USA, Canada - Intensive Care Med.).
Cost-minimization analysis of negative pressure wound therapy technologies for the treatment of moderate-to-severe foot infections - Nih.gov
Abstract by Peter J Mallow, Jon Tepsick, Kathryn E Davis and Lawrence A Lavery (USA - J Comp Eff Res.).
Cutaneous manifestations of COVID-19: A systematic review - Nih.gov
Abstract by Harjas Singh, Harleen Kaur, Kanhaiya Singh and Chandan K Sen (USA - Adv Wound Care (New Rochelle)).
Fungal Infections in Burn Patients - Nih.gov
Abstract by Alen Palackic, Daniel Popp, Christian Tapking, Khosrow S Houschyar and Ludwik K Branski (Austria, Germany, USA - Surg Infect (Larchmt)).
Intensive Treatment of Lower-Limb Lymphedema and Variations in Volume Before and After: A Follow-Up - Nih.gov
Abstract by Jose Maria Pereira de Godoy, Maria de Fatima Guerreiro Godoy, Stelamarys Barufi and Henrique Jose Pereira de Godoy (São José do Rio Preto, Brasil - Cureus).
Professional project for wound healing clinicians - Wiley.com
Article by Anna Milena Galazka. Wound healing is a novel medical area focused on the treatment of skin tears. Until the second half of the 20th century, the understanding of wound healing hinged largely on changing bandages. As the demand for advanced wound care has grown in ageing western populations, the past 60 years have seen progress in its biomedical knowledge base.
Steps for Preventing Cross-Contamination in Post-Operative Wound Care - Woundsource.com
An estimated 3% to 27% of surgical patients have unforeseen post-operative complications, such as infections, wound dehiscence, deep vein thrombosis, and pulmonary embolism. Prevention of these complications includes aseptic practices, exercises, hydration, and the use of advanced wound care products.
Dressing interventions to heal pressure ulcers: A protocol for an overview of systematic reviews and meta-analysis - Nih.gov
Abstract by Jie Geng, Yitong Cai, Yali Zhao, Zheyuan Wang, Mancai Wang and Zhihong Wei (Gansu, China - Medicine (Baltimore)).
A point-of-care app for chronic oedema management - Nih.gov
Abstract by Mercita Collett (Wiltshire, UK - Br J Community Nurs.).
Why Every Wound Center Should Have a Lymphedema Specialist - Todayswoundclinic.com
Article by Heather Hettrick. Wound healing can be maximized by the management of edema, and offering lymphedema services in the wound clinic can be an ideal solution. This author details the value of a certified lymphedema therapist or certified lymphedema and wound therapist can bring to your patients and practice.
Experimental Simulation Study to Assess Pressure Distribution of Different Compression Applications Applied Over an Innovative Primary Wound Dressing - Woundresearch.com
Article by Suzie Ehmann, Kyle J. Walker, Cameron M. Bailey and John D. DesJardins. Compression is integral to the management of edema and the prevention of venous leg ulcers (VLUs). The aim of this study is to assess the sub-bandage pressure distribution under 3 compression applications as well to assess the impact of an innovative primary wound dressing, applied under the compression products, on pressure distribution.
The Alzheimer patient from the dermatologist's point of view - Nih.gov
Abstract by Andrea Michelerio and Carlo F Tomasini (Pavia, Italy - G Ital Dermatol Venereol.).
The Quality of Life and Psychosocial Implications of Cancer-Related Lower-Extremity Lymphedema: A Systematic Review of the Literature - Nih.gov
Abstract by Catharine Bowman, Katherine-Ann Piedalue, Mohamad Baydoun and Linda E Carlson (Calgary, Canada - J. Clin. Med.).
New scalpel increases wound healing - Dermatologytimes.com
Article by Morgan Petronelli. Entrepix Medical, LLC, a medical technology startup, announces the launch of their patented Planatome Technology, an advanced nano-polishing technology that can be used on surgical instruments to create a smooth and precise blade that minimizes surgically-induced tissue trauma.
Cost Effectiveness of Fish Skin Grafts Versus Standard of Care on Wound Healing of Chronic Diabetic Foot Ulcers: A Retrospective Comparative Cohort Study - Woundresearch.com
Article by Christopher Winters, Robert S. Kirsner, David J. Margolis and John C. Lantis II (Wounds).
Including fish skin grafts in the standard of care (SOC) for diabetic foot ulcers (DFU) treatment has the potential to reduce costs while improving patient outcomes.
Does Hyperbaric Oxygen Improve Lower Extremity Ulcer Outcomes? - Woundresearch.com
Article by Laura Bolton (Wounds). A person with a diabetic foot ulcer (DFU) requires multidisciplinary care, including moist wound healing, consistent offloading of insensate areas, glycemic control, and adequate circulation. This is especially important during the COVID-19 pandemic, as patients with diabetes are at a higher risk of mortality.
Are Chronic Wounds a Growing Problem? - Communalnews.com
Chronic wounds are wounds which have failed to proceed through an orderly and timely reparative process, usually within a period of 3 months. The Wound Healing Society (WHS) notes that chronic wounds affect an estimated 1 to 2% of the population. As people age, wound closure becomes more difficult.
Predictive value of the prognostic nutrition index for the prognosis of patients with severe burns treated with the Meek graft - Nih.gov
Abstract by Gaozhong Hu, Lili Yuan, Yizhi Peng, Gaoxing Luo and Huapei Song (Chongqing, China - J Burn Care Res.)
How Liquid Protein May Promote Wound Healing - Opslens.com
Whether accidental – or planned through surgery – wounds can really put a wrench in your routine. We would all like to get back on our feet as quickly as possible. But, sometimes it feels like wounds take forever to heal. The good news is, you may be able to drastically reduce your recovery time with collagen protein.
Preparation, characterization and in vitro wound healing activity of collagen-chitosan film - Pharmascope.org
Article by Ragini B, Shree Rama M, Shaukat Ali SR and Siva S (Tamilnadu, India - International Journal of Research in Pharmaceutical Sciences).
It was concluded that this present study reveals that the preparation of collagen-chitosan films from a new source of natural collagen could be suitable for the application of wound dressings.
Clinical application and efficacy of negative pressure wound therapy with instillation and dwell time (NPWTi-d): A systematic review and meta-analysis - Nih.gov
Abstract by Muholan Kanapathy, Angelos Mantelakis, Natasha Khan, Ibby Younis and Afshin Mosahebi (London, UK - Int Wound J.).
Electric Factors in Wound Healing - Liebertpub.com
Abstract by Paulo Luiz Farber, Felipe Contoli Isoldi and Lydia Masako Ferreira (Advances in Wound Care).
Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications - Mdpi.com
Article by Sibusiso Alven, Xhamla Nqoro and Blessing Atim Aderibigbe (Eastern Cape, South-Africa - Polymers).
Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.
Wound healing and PMN function at hydrophilic‐surface titanium‐zirconium implants in diabetic and healthy patients - Wiley.com
Abstract by Doğan Kaner, Hakan Bilhan, Amelie Hauser, Daniel Diehl and Anton Friedmann (Clinical Oral Implants Research).
Evaluating the antibacterial, antioxidant and wound healing properties of the stem bark extract of Khaya grandifoliola (Welw) CDC (Meliaceae) (African Mahogany) - Academicjournals.org
Abstract by Anna Naa Kwarley Quartey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Phoebe Esinam Goku, Fadila Alidu and Linda Owusu Boateng (Journal of Medical Plants Research).
Molecular mechanisms underlying wound healing acceleration by Staphylococcus aureus peptidoglycan - Wiley.com
Abstract by Xiaoguang Liu, Stanley M. Levenson, Tsueng H. Chang, Jacob J. Steinberg, Obi Imegwu and Marcos Rojkind (Wound Repair and Regeneration). First published: October 1996
Phytochemical profile, antioxidant activity and wound healing properties of Artemisia absinthium essential oil - Apjtb.org
Article by A Benkhaled, A Boudjelal, E Napoli, F Baali and G Ruberto (Algeria, Italy - Asian Pacific Journal of Tropical Biomedicine). The essential oil of Artemisia absinthium shows moderate antioxidant activity. The 10% ointment enhances skin wound re-epithelialization and speeds up the healing process. The essential oil of Artemisia absinthium may be used as an alternative drug for wound healing.
Cuscuta reflexa Roxb. Expedites the Healing Process in Contact Frostbite - Hindawi.com
Article by Waseem Hassan, Manal Ali Buabeid, Umme Kalsoom, Sahar Bakht, Imran Akhtar, Furqan Iqbal and El-Shaimaa A. Arafa (Pakistan, UAE, Egypt - BioMed Research International).
Cs.Cr is significantly effective in frostbite through the reduction of inflammation, although further studies should be performed to identify the molecular mechanism of these biological activities.
Comparison Among Bone Marrow and Wheat Flour’s Mixture and Standard Treatment on Healing Second-Degree Burn Wound in Rats - Oup.com
Abstract by Saboreh Jafari, Rostam Jalali, Cyrus Jalili and Tahereh Jamshidpoor (Journal of Burn Care & Research).
Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device - Biorxiv.org
Article by Robert S. Kellar, Robert Diller, Aaron J Tabor, Dominic Dominguez, Robert Audet, Tatum Bardsley, Alyssa Talbert, Nathan Cruz, Alison Ingraldi and Burt Ensley (USA).
The WHD in a splinted, full-thickness, diabetic murine wound healing model demonstrated an enhanced rate of wound closure, decreased tissue inflammation, skin organ regeneration, and a stronger and more durable remodeled tissue that more closely mimics native unwounded skin compared to the control device.
Use Of Cadexomer Iodine And Povidone Iodine In Wound Management: A Comparative Review - Medicaldialogues.in
Article by Hina Zahid. Iodine is a highly effective topical antimicrobial that has been used clinically in the treatment of wounds for more than 170 years. It has a broad spectrum of antimicrobial activity with efficacy against bacteria, mycobacteria, fungi, protozoa and viruses and can be used to treat both acute and chronic wounds.
Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute - Nih.gov
Abstract by Fabien Kawecki, Dominique Mayrand, Akram Ayoub, Emilie Attiogbe, Lucie Germain, Francois A Auger and Veronique J Moulin (Quebec, Canada - Biomed Mater.).
Low cost, modified negative pressure wound therapy in infected orthopaedic wounds: can it be as effective as its costly counterparts? - Nih.gov
Abstract by Sumedh Chaudhary, Vikram Kumar, Pratik Gandhi, Maruti Koichade and Sourav Mandal (Nagpur, India - J Clin Orthop Trauma).
Postoperative negative pressure wound therapy is associated with decreased surgical site infections in all lower extremity amputations - Nih.gov
Abstract by Owen B Gantz, Nicole D Rynecki, Ashok Para, Michael Levidy and Kathleen S Beebe (USA - J Orthop.).
Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation - Mdpi.com
Article by Nasrul Wathoni, Diah Permata Sari, Ine Suharyani, Keiichi Motoyama, Ahmed Fouad Abdelwahab Mohammed, Arief Cahyanto, Marline Abdassah and Muchtaridi Muchtaridi (Indonesia, Japan, Egypt - Pharmaceuticals).
α-Mangostin (α-M), one of the active compounds in Garcinia mangostana peel, has been effectively used in wound healing. However, its poor solubility in aqueous solution causes low bioavailability for skin ulcers, hindering its application in wound healing. The aim of this study was to improve the solubility of α-M through complex formation with 2-hydroxypropyl-β-cyclodextrin (α-M/HP-β-CD CX) and to evaluate the healing activity of the complex.
Preventing Post-Operative Complications - Woundsource.com
Surgical complications impact many patients every year, and when post-operative complications occur, they can disrupt the normal healing cycle and introduce new challenges in patient care. It is estimated that between 3% and 27% of surgical patients have unforeseen complications related to their surgical event.
Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts - Nih.gov
Abstract by Auspreeya Rujirachotiwat and Supaporn Suttamanatwong (Bangkok, Thailand - Eur J Dent.).
The Association of Cesarean Skin Incision Length and Postoperative Wound Complications - Nih.gov
Abstract by Akila Subramaniam, Victoria Jauk, George Saade, Kim Boggess, Sheri Longo, Erin A S Clark, Sean Esplin, Kirsten Cleary, Ron Wapner, Kellett Letson, Michelle Y Owens, Sean Blackwell, Jeff M Szychowski, William W Andrews and Alan T Tita (USA - Am J Perinatol.).
Peripheral Arterial Disease in Persons with Diabetic Foot Ulceration: a Current Comprehensive Overview - Eurekaselect.com
Abstract by Meloni Marco, Izzo Valentina, Morosetti Daniele, Da Ros Valerio, Panunzi Andrea, Gandini Roberto, Giurato Laura and Uccioli Luigi (Current Diabetes Reviews).
Mechanistic Actions of microRNAs in Diabetic Wound Healing - Mdpi.com
Article by Marija Petkovic, Anja Elaine Sørensen, Ermelindo Carreira Leal, Eugenia Carvalho and Louise Torp Dalgaard (Denmark, Portugal, USA - Cells). Both microRNA mimics, to enhance the expression of important microRNAs that are needed to induce healing, but are decreased under diabetic conditions, and antagomirs, which inhibit specific microRNAs that have been found highly expressed under diabetic conditions, can now be developed as therapeutic targets. These targets can be directed at very specific pathways that are known to be impaired under diabetes conditions and in particular during the various phases of wound healing.
A biocompatible PAA-Cu-MOP hydrogel for wound healing - Rsc.org
Article by Linlin Chen, Yu Qin, Jing Cheng, Yi Cheng, Zhixiang Lu, Xiaolan Liu, Shaoxiong Yang, Shuhan Lu, Liyan Zhengand and Qiue Cao (China - RSC Advances).
The authors have successfully prepared hydrogel directly from Cu-MOP, glycerol and PAA by a facile procedure. The PAA-Cu-MOP hydrogel with favorable moisture retention, antibacterial activity and procoagulant ability was used to accelerate the wound healing process in vivo without any toxicity.
Scientists reactivate scar-free wound healing in adult skin - Newatlas.com
Article by Ben Coxworth. When surgery is performed on infants in utero, it's not uncommon for them to be born without any scars. This comes thanks to a special quality of their skin which scientists now believe could be replicated in adults, potentially leading to scar-free wound treatments.
Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels - Nih.gov
Abstract by Trivia Frazier, Andrea Alarcon, Xiying Wu, Omair A Mohiuddin, Jessica M Motherwell, Anders H Carlsson, Robert J Christy, Judson V Edwards, Robert T Mackin, Nicolette Prevost, Elena Gloster, Qiang Zhang, Guangdi Wang, Daniel J Hayes and Jeffrey M Gimble (USA - Biomolecules).
Bioinspired Nanofibrous Glycopeptide Hydrogel Dressing for Accelerating Wound Healing: A Cytokine‐Free, M2‐Type Macrophage Polarization Approach - Wiley.com
Abstract by Zujian Feng, Qi Su, Chuangnian Zhang, Pingsheng Huang, Huijuan Song, Anjie Dong, Deling Kong and Weiwei Wang (Advanced Functional Materials).
Genetic Switch in Early Development Can Activate Skin Repair Without Scarring - Sciencetimes.com
Article by Hannah C. Understanding how the skin repairs itself instead of scarring in a healing process is important for clinical and cosmetic applications. In a recent study, scientists discovered a genetic factor that allows adult skin to regenerate, similar to a newborn baby's.
The study by Washington State University was published in the journal eLife. Studying skin regeneration can help burn victims and patients with skin conditions.
Wound healing: cellular mechanisms and pathological outcomes - Royalsocietypublishing.org
Article by Holly N. Wilkinson and Matthew J. Hardman. The high cellular diversity, complexity and plasticity of wound healing provide a considerable challenge to comprehensively elucidate. While this remains a perplexing goal, it is essential that we continue to strive to more fully understand the mechanisms that underpin both normal and pathological healing.
Managing the ‘Weepy Leg’ of Chronic Wound Edema - Todayswoundclinic.com
Article by Frank Aviles Jr. In this article, the author would like to discuss what edema is, possible causes, and what happens when not addressed properly such as typically encountered in weeping legs. He will refer to the traditional Starling principle, but be aware that the revised Starling principle indicates an increase role for the lymphatic and not the venous system in removing drainage.
Leclercia adecarboxylata causing necrotising soft tissue infection in an immunocompetent adult - Nih.gov
Abstract by Molly K Lonneman, Rebekah J Devasahayam and Cody J Phillips (USA - BMJ Case Rep.).
Polydopamine-assisted PDGF-BB immobilization on PLGA fibrous substrate enhances wound healing via regulating anti-inflammatory and cytokine secretion - Plos.org
Article by Xiao Yang, Peng Zhan, Xiuyan Wang, Qiushuang Zhang, Yi Zhang, Haitao Fan, Ranwei Li and Ming Zhang (Changchun, China).
The pDA/PLGA/PDGF-BB substrate showed great therapeutic effect on wound healing compared with other control groups via regulating anti-inflammatory, angiogenesis, and cellular proliferation. Absolutely, this report offered an available novel method for skin regeneration.
All About Tunneling Wounds and Their Treatment - Healthline.com
An open wound is an unsettling sight. But what you may not see underneath the wound can be more unsettling. Tunnels underneath the skin’s surface mean the wound isn’t healing well. Tissue is being damaged, and without the right care, even more serious complications can occur.
Negative Pressure Wound Therapy in Malignancy: Always an Absolute Contraindication? - Nih.gov
Abstract by Lacey R Pflibsen, Salvatore C Lettieri, Erwin A Kruger, Alanna M Rebecca and Chad M Teven (Phoenix, USA - Plast Reconstr Surg Glob Open).
Data for pressure ulcers and skin infections after cochlear implantation - Nih.gov
Abstract by Hui-Shan Hsieh, Chee-Yee Lee, Hung-Pin Wu, Ming-Ying Zhuo and Chung-Feng Hwang (China, Taiwan - Data Brief).
Efficacy of resveratrol in the wound healing process by reducing oxidative stress and promoting fibroblast cell proliferation and migration - Wiley.com
Abstract by Belisa Kaleci and Meral Koyutürk (Dermatologic Therapy).
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