Wound-healing waves - Eurekalert.org
Researchers at IST Austria find a complex interplay among cells, which guides them to where they need to go. Many cells in our bodies are on the move and somehow seem to "know" where to go. But how do they learn the location of their destination? This question is key to understanding phenomena such as the renewal of cells in our body, the migration of cancer cells, and especially how wounds heal.
Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing - Mdpi.com
Article by Anika Haq † Suneel Kumar†, Yong Mao, Francois Berthiaume and Bozena Michniak-Kohn (Piscataway, USA - Biomedicines).
Based on their data the authors can conclude that significant bacterial reduction by TQ film has the potential to provide a new treatment strategy especially for those patients who have developed resistance towards the commonly used antibacterial agents. TQ/PVP films and hydrogels developed in this study have the potential for the treatment and management of wound and S. aureus related bacterial skin and wound infections.
Activity and Effectiveness of Recombinant hEGF Excreted by Escherichia coli BL21 on Wound Healing in Induced Diabetic Mice - Dovepress.com
Article by Sriwidodo Sriwidodo, Iman Permana Maksum, Toto Subroto, Nasrul Wathoni, Anas Subarnas and Abd Kakhar Umar (Jatinangor, Indonesia - Journal of Experimental Pharmacology).
Recombinant hEGF produced by extracellular secretion using E. coli BL21 has optimal diabetic wound healing activity through increased fibroblast proliferation.
Characterization of an oxidized alginate-gelatin hydrogel incorporating a COS-salicylic acid conjugate for wound healing - Sciencedirect.com
Abstract by Gun-Woo Oh, Se-Chang Kim, Tae-Hee Kim and Won-KyoJung (Busan, South-Korea - Carbohydrate Polymers).
Advantages in Wound Healing Process in Female Mice Require Upregulation A2A-Mediated Angiogenesis under the Stimulation of 17β-Estradiol - Mdpi.com
Article by Felipe Troncoso, Kurt Herlitz, Jesenia Acurio, Claudio Aguayo, Katherine Guevara, Fidel Ovidio Castro, Alejandro S. Godoy, Sebastian San Martin and Carlos Escudero (Chile - IJMS).
The interaction between ER and A2A in the regulation of angiogenesis brings a new area of research into the complex regulatory scenario of the healing process.
Health Care Spending in Patients With Stage 3 and Stage 4 Pressure Injuries and Patients With Diabetic Foot Ulcers Treated Early With Clostridial Collagenase Ointment: A Retrospective Data Review - Woundresearch.com
Article by Jeffrey D. Lehrman, Ankur Patel and Gary Delhougne (USA, UK).
The objective of this study is to estimate health care spending among patients with Stage 3 and Stage 4 pressure injuries (PIs) and patients with diabetic foot ulcers (DFUs) who experienced early (ie, within 30 days of index diagnosis) versus late (31 to 90 days of index diagnosis) initiation of CCO.
Skin Failure Clinical Indicator Scale: Proposal of a Tool for Distinguishing Skin Failure From a Pressure Injury - Woundresearch.com
Article by Richard Hill and Amy Petersen (USA).
The Skin Failure Clinical Indicator Scale (SFCIS), a proposed tool that uses readily available variables to assist in more definitively identifying skin failure, was developed and assessed.
Post-Event Huddle to Decrease Hospital-Acquired Pressure Injuries - Wouncarelearningnetwork.com
Poster by Rebecca Stevens and Amanda Dominguez.
Multiple action items have been identified and implemented, including: staff education on medical-device-related pressure injury prevention, WOC nurse rounding on patients with Braden scale < 14, bedside “4 eyes” assessment during nursing rounds, and staff nurse driven implementation of PI prevention interventions based on the Braden scale score.
Chronic wounds: Current status, available strategies and emerging therapeutic solutions - Nih.gov
Abstract by Kevin Las Heras, Manoli Igartua, Edorta Santos-Vizcaino and Rosa Maria Hernandez (Vitoria-Gasteiz, Spain - J Control Release).
A novel "hot spring"-mimetic hydrogel with excellent angiogenic properties for chronic wound healing - Sciencedirect.com
Article by Lili Sheng, Zhaowenbin Zhang, Yu Zhang, Endian Wang, Bing Ma, Qing Xu, Lingling Ma, Meng Zhang, Ge Pei and Jiang Chang (China - Biomaterials).
The authors' study suggests that the hot-spring-mimetic biomaterial design has the potential for development of new biomaterials for wound healing and the combination of bioactive ions with mild heat treatment might be an effective approach for enhanced tissue regeneration.
Exosomal Vimentin From Adipocyte Progenitors Accelerates Wound Healing - Nih.gov
Abstract by Sepideh Parvanian, Fuxia Yan, Dandan Su, Leila S Coelho-Rato, Arun P Venu, Peiru Yang, Xiaoheng Zou, Yaming Jiu, Hongbo Chen, John E Eriksson and Fang Cheng (China, Finland - Cytoskeleton (Hoboken)).
Effects of cycle periods and pressure amplitudes of alternating pressure on sacral skin blood flow responses - Nih.gov
Abstract by Fu-Lien Wu, Zhi Zheng, Yinyin Ma, Kaixiang Weng, Fuyuan Liao and Yih-Kuen Jan (USA, China - J Tissue Viability).
Thirty-nine cases of stage 4 pressure ulcers treated by a two-stage method of debridement and skin flap transfer - Nih.gov
Abstract by Y B Shen, M Xia, H W Ke, L S Zhang, L Q Xia, C H Gao and L Liu (Urumqi, China - Zhonghua Shao Shang Za Zhi.).
Effectiveness and Tolerability of a Patch Containing Onion Extract and Allantoin for Cesarean Section Scars - Frontiersin.org
Article by Valeria Conti†, Graziamaria Corbi†, Teresa Iannaccone, Bianca Corrado, Luigi Giugliano, Serena Lembo, Amelia Filippelli and Maurizio Guida (Italy, Front. Pharmacol.) Intense treatment of just 4 weeks with a patch containing Alium Cepa extract and allantoin was able to improve pigmentation, relief, and pliability of C-section scars in women with a history of C-section.
Novel alkaline Hydrogel ‘advances skin wound care’ - Iwoundsnews.com
Scientists at the Tokyo University of Science (Tokyo, Japan) have developed a novel method to produce an alkaline hydrogel that can help improve wound healing. The method requires no specialised equipment and can be performed at room temperature to produce an alkaline hydrogel in five minutes, allowing its easy implementation, researchers behind the technique say.
5% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre Observational Study - Nih.gov
Abstract by Agata Janowska, Giovanni Papa, Marco Romanelli, Giulia Davini, Teresa Oranges, Chiara Stocco, Zoran Marji Arnez and Valentina Dini (Italy - J Invest Surg.).
Outcomes for Pressure Ulcer Trials (OUTPUTs) project: first key step on a long journey - Nih.gov
Abstract by V Eleftheriadou (Nottingham, UK - Br J Dermatol.).
Diabetic Foot. Part 1: Ulcers and Infections - Nih.gov
Abstract by Ricardo Cardenuto Ferreira (São Paulo, Brasil - Rev Bras Ortop.).
Venous leg ulcers heal faster with early surgery vs. compression, trial shows - Mcknigts.com
Article by Alicia Lasek.
Venous leg ulcers heal faster and return less frequently in patients who have early surgery when compared with their peers who wear compression stockings and delay surgery, a new clinical trial has shown.
Venous leg ulcers can be caused by enlarged varicose veins that are common in older adults, especially women. The resulting sores may take months to heal. For five years, investigators followed outcomes in 450 patients who had early endovenous ablation, a minimally invasive surgical procedure, to close the enlarged veins.
Negative pressure wound therapy - does it lower the risk of complications with closed wounds following breast surgery? - Nih.gov
Abstract by Nicholas Charles Holford (Reading, UK - Expert Rev Med Devices).
Successful treatment of necrotizing fasciitis using handmade negative pressure system wound therapy - Nih.gov
Abstract by Víctor H García-Orozco, Carlos Solar-Aguirre and Iván López-Yerena (México - Cir. Cir.).
EGFR-conjugated hydrogel accelerates wound healing on ulcer-induced burn wounds by targeting collagen and inflammatory cells using photoimmunomodulatory inhibition - Sciencedirect.com
Abstract by Karuppusamy Shanmugapriya, Hyejin Kim and Hyun Wook Kang (Busan, South-Korea - Materials Science and Engineering: C).
Facial pressure ulcers in COVID-19 patients undergoing prone positioning: How to prevent an underestimated epidemic? - Nih.gov
Abstract by A Perrillat, J-M Foletti, A-S Lacagne, L Guyot and N Graillon (Marseille, France - J Stomatol Oral Maxillofac Surg.).
Negative pressure wound therapy does not cut infection risk in obese women after cesarean delivery - Nih.gov
Negative pressure wound therapy (NPWT) does not appear to lower the risk of infection for obese women after cesarean delivery, suggests a study funded by the National Institutes of Health. The treatment involves placing a low-pressure pump over a closed surgical wound to create negative air pressure. Earlier studies had suggested that NPWT might reduce infection risk and promote healing after surgery. The study of more than 1,600 obese women found no significant difference in infection between women treated with NPWT and those receiving standard wound dressing.
Lower Extremity Wounds: The Patient Impact - Woundsource.com
Wounds of the lower extremity, such as chronic venous leg ulcers and diabetic foot ulcers, often have a severe impact on patients' quality of life. Symptoms may range from mild to debilitating, depending on the location of the injury and its severity. These types of wounds also affect a tremendous number of people because lower extremity wounds are estimated to occur in up to 13% of the United States population. The estimated annual cost of treating lower extremity wounds is at least $20 billion in the United States.
The effects of body position on the material properties of soft tissue in the human thigh - Nih.gov
Abstract by Justin Scott, Sheng Chen, Sara Roccabianca and Tamara Reid Bush (East Lansing, USA - J Mech Behav Biomed Mater.).
Anti-inflammatory, Analgesic and In vivo-In vitro Wound Healing Potential of the Phlomis rigida Labill. Extract - Sciencedirect.com
Abstract by Mehmet Evren Okur, Ayşe Esra Karadağ, Yağmur Özhan, Hande Sipahi, Şule Ayla, Benay Daylan, Şükran Kültür, Betül Demirci and Fatih Demirci (Turkey - Journal of Ethnoparmacology).
From Diabetic Foot Ulcers to Limb Salvage: A Surgical Perspective - Todayswoundclinic.com
Article by Efthymios Gkotsoulias. The burden of diabetic foot ulcers (DFUs) to patients and the health care system is substantial. Although we understand why DFUs happen and have relatively effective treatments (particularly if they are caught early), we still don’t seem to be winning against this mutilating disease. Why?
How Correct Positioning Can Prevent Pressure Injuries - Todayswoundclinic.com
Article by Diane Holland. Positioning patients properly may aid in preventing pressure injuries. This author provides a practical guide to correct positioning and specialized positioning for those with special conditions, as well as a look at an innovative positioning product.
Insights on Remote Monitoring for Diabetic Foot Ulcers - Todayswoundclinic.com
Article by Barbara Aung. With the isolation caused by the pandemic, remote monitoring for patients with diabetes is more critical than ever to get information on patients’ adherence. This author takes a closer look at several remote monitoring technologies, offering guidance for use and coding.
Bio-Based Electrospun Fibers for Wound Healing - Mdpi.com
Abstract by Bahareh Azimi, Homa Maleki, Lorenzo Zavagna, Jose Gustavo De la Ossa,Stefano Linari, Andrea Lazzeri and Serena Danti (Italy, Iran - J. Funct. Biomater.).
Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair - Dovepress.com
Article by Dong J, Wu Y, Zhang Y, Yu M and Tian W (China - International Journal of Nanomedicine). The authors' results demonstrated that sEV derived from the same tissues of different species might be loaded with similar therapeutic substance benefitting tissue repair and regeneration, and paved the way for future research aimed at xenogeneic sEV application.
Chronic Wounds: How Self-care Can Help Speed Healing - Thedoctorweighsin.com
Article by Jeffrey Nelson. Optimal self-care for patients with chronic wounds includes dressing changes, good nutrition, and recognizing warning signs of infection.
Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing - Nih.gov
Abstract by Beata Kaczmarek, Olha Mazur, Oliwia Miłek, Marta Michalska-Sionkowska, Anna M Osyczka and Konrad Kleszczyński (Poland, Germany - Prog Biomater.).
Current operative management and therapeutic algorithm of lymphedema in the lower extremities - Nih.gov
Abstract by Savitha Ramachandran, Khong-Yik Chew, Bien-Keem Tan and Yur-Ren Kuo (Taiwan, Singapore - Asian J Surg.).
The Effect of Topical Administration of an Ointment Prepared From Trifolium repens Hydroethanolic Extract on the Acceleration of Excisional Cutaneous Wound Healing - Woundresearch.com
Article by Seied Kiavash Habibi Zadeh, Mohammad-Reza Farahpour and Hamed Hamishe Kar (Iran). The purpose of this study is to evaluate the in vivo wound healing potential of an ointment prepared from Trifolium repens hydroethanolic extract concerning excisional wounds in a rat model.
Biopolymer film fabrication for skin mimetic tissue regenerative wound dressing applications - Tandfonline.com
Abstract by Logesh Kumar Sellappan, Sanmugam Anandhavelu, Mukesh Doble, Govindaraj Perumal, Ji-Hoon Jeon, Dhanasekaran Vikraman and Hyun-Seok Kim (International Journal of Polymeric Materials and Polymeric Biomaterials).
Successful Full-Thickness Skin Regeneration Using Epidermal Stem Cells in Traumatic and Complex Wounds: Initial Experience - Cureus.com
Article by Arthur Berg, Sanjeev Kaul, Gregory E. Rauscher, Melissa Blatt and Stephen Cohn. The authors describe the index case series utilizing a novel tissue based, autologous, homologous epidermal stem cell derived product in complex surgical wounds. These wounds on average were very large and likely not amenable to traditional skin grafting. Despite requiring only a small full thickness donor skin specimen, more than 90% of the patients had a 100% graft survival covering large and complicated wound surfaces, and many experienced normal sensation at the healed graft site.
Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization - Mdpi.com
Article by Isabel Andia, Arantza Perez-Valle, Cristina Del Amo and Nicola Maffull (Spain, Italy, UK - Int. J. Mol. Sci.).
The authors present the current state of experimental and clinical FD-PRP research in the different medical areas in which PRP has potential to meet prevailing medical needs. A systematic search, according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analyses) guidelines, showed that research is mostly focused on wound healing, i.e., developing combination products for ulcer management. Injectable hydrogels are investigated for lumbar fusion and knee conditions.
Catecholamines in the regulation of angiogenesis in cutaneous wound healing - Wiley.com
Article by Debanjan Chakroborty, Sandeep Goswami, Sujit Basu and Chandrani Sarkar. Angiogenesis involves the formation of new blood vessels from preexisting ones, and it is an essential step during cutaneous wound healing, which supports cells at the wound site with nutrition and oxygen. Impaired angiogenesis in the wound tissues results in delayed wound closure and healing. Among the regulators of angiogenesis, the role of catecholamines (epinephrine, norepinephrine, and dopamine) is of interest due to their diverse roles in the process of wound healing.
A review on the synthesis of graft copolymers of chitosan and their potential applications - Nih.gov
Abstract by Deepak Kumar, Sachin Gihar, Manoj Kumar Shrivash, Pramendra Kumar and Patit Paban Kundu (India - Int J Biol Macromol.).
Effects of topical application of CHF6467, a mutated form of human nerve growth factor, on skin wound healing in diabetic mice - Nih.gov
Abstract by A Giuliani, L Lorenzini, V A Baldassarro, M Pannella, M Cescatti, M Fernandez, G Alastra, A Flagelli, G Villetti, B P Imbimbo, L Giardino and L Calza (Bologna, Italy - J Pharmacol Exp Ther.).
Negative pressure therapy for stoma closure sites-a nonrandomised case control study - Nih.gov
Abstract by N Obeid, E Sharma, M Dunstan, P Nisar, P Trivedi, R Madani, H J Scott, J P Trickett, P E Bearn and G P Thomas (Surrey, UK - Int J Colorectal Dis.).
Role of periostin in skin wound healing and pathologic scar formation - Lww.com
Article by Shi-Lu Lin, Ze-Lian Qin and Xin Yang (Beijing, China - Chinese Medical Journal). The skin is the outermost protective organ susceptible to damage by external injury and retains undesired scars after wound healing, which often diminishes the quality of life and causes economic burden. Periostin, an extracellular matrix component, is reportedly closely associated with skin wound healing and pathologic scar formation. It is expressed in various normal tissues, often associated with fibroblasts, and involved in remodeling of the extracellular matrix environment.
Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract - Acs.org
Article by Amit K. Mittal, Rohit Bhardwaj, Riya Arora, Aarti Singh, Monalisa Mukherjee and Satyendra K. Rajput. In the present study, herbal medicine-based polymeric hybrid polymeric hydrogels were developed to examine biocompatibility, accelerate tissue regeneration, and improve the efficiency in the diabetic animal tissue system. Polymeric hybrid hydrogel as well as pDPi-DMAEMA–HA hybrid hydrogel was found to have enhanced swelling and wound healing effectiveness properties as compared to the other available marketed formulations.
Kikuhime Device in the Management of Venous Leg Ulcers - Nih.gov
Abstract by Marian Karafa and Anna Karafova (Gdansk, Poland - Clin Interv Aging).
The subepidermal moisture scanner: the technology explained - Nih.gov
Abstract by Amit Gefen and Graham Ross (Israel, USA - J Wound Care).
Pressure ulcer healing with an intensive nutrition intervention in an acute setting: a pilot randomised controlled trial - Nih.gov
Abstract by M D Banks, L J Ross, J Webster, A Mudge, M Stankiewicz, K Dwyer, K Coleman and J Campbell (Australia - J Wound Care).
A 9-year retrospective evaluation of 102 pressure ulcer reconstructions - Nih.gov
Abstract by K A Kenneweg, M C Welch and P J Welch (USA - J Wound Care).
How Wearable Patch Helps in Effective Wound Care - Medicaltechoutlook.com
The latest wound monitoring technology, the wearable patch, will change how the healthcare industry deals with chronic wound care. Connected to a smartphone, the wearable patch allows continuous monitoring of wounds, to help caregivers and wound sufferers with a smart and accurate evaluating tool.
Predictors of Surgical Site Infections Among Patients With Diabetes Mellitus Post Coronary Artery Bypass Graft Surgery: A Quasi-experimental Study - Woundresearch.com
Article by Audai A. Hayajneh, Issa M. Hweidi and Ala M. Zytoon (Jordan, Wounds.) Three key factors were found to predict the occurrence of SSIs in patients with DM undergoing CABG. These findings underscore the necessity for health care providers to adhere to and employ meticulous infection control practices when managing at-risk CABG patients.
Evidence for person-centred care in chronic wound care: A systematic review and recommendations for practice - Nih.gov
Abstract by Martin C Jordan, Sebastian Jovic, Fabian Gilbert, Andreas Kunz, Maximilian Ertl, Ute Strobl, Rafael G Jakubietz, Michael G Jakubietz, Rainer H Meffert and Konrad F Fuchs (Würzburg, Deutschland - Unfallchirurg.).
Smartphone-based photographic wound documentation improves the quality of medical accounting in orthopedic and plastic surgery - Nih.gov
Abstract by Georgina Gethin, Sebastian Probst, Jan Stryja, Natalia Christiansen and Patricia Price (Australia, Switzerland, Czech Republic, UK - J Wound Care).
Cellular Restoration of Leg and Foot Ulcers - Woundsource.com
Chronic wounds pose an ongoing challenge for clinicians, and there needs to be a clearer understanding of the pathophysiology of wound chronicity and treatment modalities available.
Inching Forward in Wound Measurement - Woundcarelearningnetwork.com
Article by Seth Snowden. Elements to wound assessment are wound location, anatomical structures, undermining or tunneling, tissue identification, exudate, odor, pain, periwound, and measurement. It is encouraging and beneficial to see improvement in any of these variables and should be documented and taken into account when formulating a treatment plan.
A New Approach to Understanding the Biology of Wound Healing - Newswise.com
Researchers use discarded wound dressings as a novel and non-invasive way to study the mechanisms that promote healing.
Wound healing cream formulated with Kalanchoe pinnata major flavonoid is as effective as the aqueous leaf extract cream in a rat model of excisional wound - Tandfonline.com
Abstract by Marcela Araújo Soares Coutinho, Livia Marques Casanova, Luana Beatriz dos Santos Nascimento, Diogo Leal, Celia Palmero, Helena Keiko Toma, Elisabete Pereira dos Santos, Luiz Eurico Nasciutti and Sônia Soares Costa.
Randomized clinical trial of negative pressure wound therapy as an adjunctive treatment for small‐area thermal burns in children - Ewma.org
Article by C. C. Frear, L. Cuttle, S. M. McPhail, M. D. Chatfield, R. M. Kimble and B. R. Griffin (BJS). Adjunctive NPWT hastened re‐epithelialization in small‐area burn injuries in children, but had a greater treatment burden than standard dressings alone.
Repositioning for preventing pressure ulcers: a systematic review and meta-analysis - Nih.gov
Abstract by Pinar Avsar, Zena Moore, Declan Patton, Tom O'Connor, Aglecia Mv Budri and Linda Nuget (Ireland, UK, China, Australia, Saudi Arabia - J Wound Care).
Effect of extracorporeal shock wave therapy for burn scar regeneration: A prospective, randomized, double-blinded study - Nih.gov
Abstract by Seung Yeol Lee, So Young Joo, Yoon Soo Cho, Gi Yeun Hur and Cheong Hoon Seo (Republic of Korea - Burns).
The impact of skin calcinosis on digital ulcers in patients with SSc: clinical and prognostic stratification using the "wound bed score" - Nih.gov
Abstract by Simone Barsotti, Valentina Venturini, Marco Di Battista, Agata Janowska, Valentina Dini, Alessandra Della Rossa and Marta Mosca (Pisa, Italy - Int. Wound J.).
Cefazolin sodium pentahydrate combined with vacuum sealing drainage in the treatment of open fracture complicated with soft tissue injury" - Nih.gov
Abstract by Wenjie Lou, Kai Zou, Zhongbin Yu, Song Qin, Kai Wang and Biao Che (Wuhan, China - Rev Assoc Med Bras.).
EWMA 2021: Abstracts - Ewma.org
The organizers are now accepting submissions for English abstracts to be presented at the EWMA 2021 Conference in Paris. Abstract submission of French abstracts will open at the end of September 2020.
Cells from discarded dressings differentiate chronic from acute wounds in patients with Epidermolysis Bullosa - Nature.com
Article by Ignacia Fuentes, Christina Guttmann-Gruber, Birgit Tockner, Anja Diem, Alfred Klausegger, Glenda Cofré-Araneda, Olga Figuera, Yessia Hidalgo, Pilar Morandé, Francis Palisson, Boris Rebolledo-Jaramillo, María Joao Yubero, Raymond J. Cho, Heather I. Rishel, M. Peter Marinkovich, Joyce M. C. Teng, Timothy G. Webster, Marco Prisco, Luis H. Eraso, Josefina Piñon Hofbauer and Andrew P. South (Chile, Austria, USA - Scientific Reports).
In conclusion the authors present a novel method for wound cell isolation that can identify differences between acute and chronic wounds, between JEB and RDEB patients, and provide a source of DNA for genetic diagnosis. Further development of this approach has the potential to delineate different subsets of innate and adaptive immune cells present in wounds which may predict chronicity.
Chitosan hydrogels functionalized with either unfractionated heparin or bemiparin improve diabetic wound healing - Sciencedirect.com
Article by Alberto Cifuentes, Verónica Gómez-Gil, Miguel A. Ortega, Ángel Asúnsolo, Santiago Coca, Julio San Román, Melchor Álvarez-Mon, Julia Buján and Natalio García-Honduvilla (Madrid, Spain - Biomedicine & Pharmacotherapy).
Wound dressings of chitosan hydrogels loaded with either HEP or BEM improved diabetes-associated impaired wound healing such that the healing process was similar to a non-compromised healing process. These chitosan hydrogels promote the progression of the reparative process and induce the formation of stable scar tissue, which is an added advantage of using the said hydrogels for diabetic wounds.
Polyurethane/carboxymethylcellulose nanofibers containing Malva sylvestris extract for healing diabetic wounds: Preparation, characterization, in vitro and in vivo studies - Sciencedirect.com
Abstract by Arash Almasian, Farhood Najafi, Mahdieh Eftekhari, Mohammad Reza Shams Ardekani, Mohammad Sharifzadeh and Mahnaz Khanavi (Iran, Canada - Materials Science and Engineering: C).
Health Care Spending in Patients With Stage 3 and Stage 4 Pressure Injuries and Patients With Diabetic Foot Ulcers Treated Early With Clostridial Collagenase Ointment: A Retrospective Data Review - Woundresearch.com
Article by Jeffrey D. Lehrman, Ankur Patel and Gary Delhougne. The objective of this study is to estimate health care spending among patients with Stage 3 and Stage 4 pressure injuries (PIs) and patients with diabetic foot ulcers (DFUs) who experienced early (ie, within 30 days of index diagnosis) versus late (31 to 90 days of index diagnosis) initiation of clostridial collagenase ointment.
Topical Antibiotic Ointment’s Place in Wound Care - Woundcarelearningnetwork.com
Article by Laura Swoboda. Topical antibiotics do have their place, mainly in the prophylaxis of infection in superficial burns and minor trauma. There are two main reasons I try to avoid the use of antibiotic ointments unless clearly indicated: antimicrobial stewardship and skin sensitivity, or allergenicity.
Wound Healing and Patients’ Pain in the Age of the Opioid Crisis - Woundcarelearningnetwork.com
How can wound care patients’ pain be targeted in the era of the opioid crisis? Hadar Lev-Tov, MD, and Daniel Federman, MD, used a case-based approach to discuss pharmacological (including medical marijuana) and non-pharmacological approaches to the wound patient with pain.
Wheel of Healing - Woundcarelearningnetwork.com
Infographics by Monique Abner. Wound care practitioners know that successful outcomes in the management of acute and chronic wounds can be impacted by biological and social conditions. This holistic model offers a consistent clinical outline for the diagnostic approach of all types of wounds, including by not limited to, diabetic, venous, and pressure ulcers, traumatic injuries, surgical wounds, and burn wounds.
Tips for Clinicians Who Are Thinking About Learning More on Compression - Woundcarelearningnetwork.com
Suzie Ehmann, DPT, CWS, CLT-LANA discusses some tips and tricks for clinicians using or thinking about getting more involved in compression.
Structural mechanics modeling reveals stress-adaptive features of cutaneous scars - Springer.com
Abstract by Biswajoy Ghosh, Mousumi Mandal, Pabitra Mitra and Jyotirmoy Chatterjee (Biomechanics and Modeling in Mechanobiology).
Physical plasma therapy accelerates wound re‐epithelialisation and enhances extracellular matrix formation in cutaneous skin grafts - Springer.com
Abstract by Nadira Frescaline, Constance Duchesne, Maryline Favier, Rachel Onifarasoaniaina, Thomas Guilbert, Georges Uzan, Sébastien Banzet, Antoine Rousseau and Jean‐Jacques Lataillade (The Journal of Pathology).
Silver dressings for the healing of venous leg ulcer. A meta-analysis and systematic review - Lww.com
Article by Zhao, Minyan; Zhang, Dongting; Tan, Liping and Huang, Hui (Suzhou, China). The results of this meta-analysis showed that the function of silver dressing in VLU was similar to that in other chronic wounds. Though no differences were observed in the rate of complete wound healing, which was probably due to the lack of long-term follow-up data, there was sufficient evidence that silver-containing dressings could accelerate the healing rate of chronic VLU and improve healing in a short time.
Overview of Current Advances in Extrusion Bioprinting for Skin Applications - Mdpi.com
Article by Arantza Perez-Valle, Cristina Del Amo and Isabel Andia (Barakaldo, Spain - Int. J. Mol. Sci.). Although we are still far from skin fabrication for regenerative medicine, the applications of bioprinted constructs also expand to the generation of in vitro models for drug discovery, which is technically easier with less regulatory constraints. These features help to speed TRL development and get earlier the market demand, while leveraging our accomplishments in biofabrication.
A Novel Use of Next-Generation Closed Incision Negative Pressure Wound Therapy After Major Limb Amputation and Amputation Revision - Cureus.com
Article by Julie West, Julia Wetherhold, Steven Schulz and Ian Valerio (Cureus).
Post-operative iNPWT is an effective way to minimize wound complications after major extremity amputation or amputation revision. This is the first case report of its kind reporting a novel use of next-generation iNPWT to optimize the post-operative residual limb. Next-generation iNPWT was safely utilized in these two cases and shows promise for this at-risk population.
Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis - Bmj.com
Article by Dereje Nigussie, Belete Adefris Legesse, Gail Davey, Abebaw Fekadu and Eyasu Makonnen (Ethiopia, UK - BMJ Open Science).
Medicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities.
Skin Microbiota and its Interplay with Wound Healing - Springer.com
Article by Marjana Tomic-Canic, Jamie L. Burgess, Katelyn E. O’Neill, Natasa Strbo and Irena Pastar (Miami, USA - American Journal of Clinical Dermatology).
In conclusion, the authors observed that interactions within mixed-species biofilms resulted in a decreased load but increased virulence of MRSA, and significantly delayed wound healing in comparison with uninfected wounds and wounds infected with single-species biofilms.
A double Dacron patch repair for right ventricle rupture during negative-pressure wound therapy of deep sternal wound infection - Nih.gov
Abstract by Martin Simek, Andrea Steriovsky and Martin Kalab (Olomouc, Czech Republic - Asian Cardiovasc Thorac Ann.).
Development and validation of CAVE score in predicting presence of pressure ulcer in intensive care patients - Nih.gov
Abstract by Suchada Ninbanphot, Pinyada Narawong, Ampornpan Theeranut, Kittisak Sawanyawisuth and Panita Limpawattana (Khon Kaen University, Thailand - Heliyon).
Application of the educational method of realistic simulation in the treatment of pressure injuries - Nih.gov
Abstract by Valéria da Silva Baracho, Maria Emília de Abreu Chaves and Thabata Coaglio Lucas (Belo Horizonte, Brazil - Rev Lat Am Enfermagem.).
The hallmarks of cancer are also the hallmarks of wound healing - Sciencemag.org
Article by Lucy MacCarthy-Morrogh and Paul Martin (UK - Science Signaling). In this review, the authors highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure.
Reducing the Recurrence of Lower Extremity Wounds - Woundsource.com
Lower extremity wounds such as diabetic foot ulcers (DFUs), venous ulcers, and arterial ulcers have been linked to poor patient outcomes, such as patient mortality and recurrence of the wound. Although precise recurrence rates can be difficult to determine and can vary across different patient populations, we do know that the recurrence rates of lower extremity wounds are quite high.
Negative pressure wound therapy as an accelerator and stabilizer for incorporation of artificial dermal skin substitutes - A retrospective, non-blinded, and non-randomized comparative study - Nih.gov
Abstract by Yannick F Diehm, Sebastian Fischer, Emre Gazyakan, Gabriel Hundeshagen, Dimitra Kotsougiani-Fischer, Florian Falkner, Ulrich Kneser and Christoph Hirche (Germany - J Plast Reconstr Aesthet Surg.).
Bioactive Self‐Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing - Wiley.com
Abstract by Feng Bao, Ge Pei, Zhongcao Wu, Hui Zhuang, Zhaowenbin Zhang, Zhiguang Huan, Chengtie Wu and Jiang Chang (Advanced Functional Materials).
Human mesenchymal stem cell-derived exosomes accelerate wound healing of mice eczema - Tandfonline.com
Abstract by Miao Wang, Yang Zhao and Qingyi Zhang (Journal of Dermatological Treatment).
Negative pressure wound treatment in a neonate with epidermolysis bullosa simplex severe generalized: A case report - Nih.gov
Abstract by Anna-Barbara Schlueer, Agnes Schwieger-Briel, Martin Theiler, Kathrin Neuhaus, Clemens Schiestl and Lisa Weibel (Zurich, Switzerland - Pediatr Dermatol.).
A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing - Biomedcentral.com
Article by Wei Lin, Xiaoyang Qi, Wenjing Guo, Danyang Liang, Heting Chen, Baoping Lin and Xiaoyuan Deng (China - Stem Cell Research & Therapy). This novel delivery system, which overcomes the limitations of conventional plain collagen-based delivery system in lacking of ROS-environmental responsive mechanisms, demonstrates a great potential use in stem cell therapies in wound healing.
The role of perineal application of prophylactic negative-pressure wound therapy for prevention of wound-related complications after abdomino-perineal resection: a systematic review - Nih.gov
Abstract by Jeremy Meyer, Elin Roos, Ziad Abbassi, Christian Toso, Frédéric Ris and Nicolas C Buchs (Switzerland, Sweden - Ann Surg.Surgery Int J Colorectal Dis.).
Outcomes for Physiologic Microsurgical Treatment of Secondary Lymphedema Involving the Extremity - Nih.gov
Abstract by Maureen Beederman, Rebecca M Garza, Shailesh Agarwal and David W Chang (Chicago, USA - Ann Surg.).
CO2 Laser Debridement and Negative Pressure Wound Therapy With Endoscopic Support for Treatment of Sinus Wound at the Ischial Tuberosity: Case Report - Nih.gov
Abstract by JiaJun Tang, Guilu Tao, Yingkai Liu, Xian Ma, Yakupu Aobuliaximu and Shuliang Lu (Shanghai, China - Int J Low Extrem Wounds).
Immune tolerance of allogeneic hematopoietic cell transplantation supports donor epidermal grafting of recessive dystrophic epidermolysis bullosa chronic wounds - Nih.gov
Abstract by C L Ebens, J A McGrath, J A Riedl, A R Keith, G Lilja, S Rusch, D R Keene, S F Tufa, M J Riddle, R Shanley, A E Van Heest and J Tolar (USA, UK - Br J Dermatol.).
Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing - Pharmaresearchlibrary.com
Article by Jeannie Devereaux, Narges Dargahi, Sarah Fraser, Kulmira Nurgali, Dimitrios Kiatos and Vasso Apostolopoulos (Melbourne, Australia - IJMS). The present study provides indications of the ability of LR-PRP and LP-PPP to induce challenged fibroblasts in vitro.
The fibroblast proliferation and wound scratch assay supported the hypothesis in which the ability of LR-PRP to affect biological responses of fibroblasts did not exhibit catabolic effects.
Surgical care does not end when the surgery ends - Molnlycke.com
Downloadable consensus document. Can you optimise healing with your post-operative dressing change protocol? Surgical care does not end when the surgery ends. Successful outcomes also depend on post-surgical incision care. Wound care dressings are a vital part of the healing equation because post-operative wounds are susceptible to infection and associated complications.
A novel treatment for skin repair using a combination of spironolactone and vitamin D3 - Wiley.com
Article by Dauren Biyashev, Unmiye V. Onay, Prarthana Dalal, Michael Demczuk, Spencer Evans, José‐Marc Techner and Kurt Q. Lu (Annals of the New York Academy of Sciences).
The authors' results demonstrate that VD in combination with SP treatment improves wound healing after NM exposure by modulating the immune response and activating anti‐inflammatory pathways. In addition to supportive treatment, this may expand the currently limited treatment options to improve clinical outcomes for NM injury.
Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays - Nature.com
Article by Monica Hellesvik, Hanne Øye and Henriette Aksnes (Scientific Reports). The authors' findings highlight several possibilities for 3D digital holographic microscopy applications combined with 3D cell preparations, therein studies of drug response or genetic alterations on invasion capacity as well as on tumour growth and metastasis.
Role of Antioxidants in Wound Healing – A Review - Pharmaresearchlibrary.com
Abstract by Gupta Sushma, Kumar Ashish, Mazumder Avijit, Chakraborthy G.S and Das Saumya (Uttar Pradesh, India).
Fluoroquinolones And Infected Wounds: What You Should Know - Podiatrytoday.com
Panelists: Warren Joseph and Robert Smith. Are fluoroquinolones safe? These panelists discuss current indications for this class of antibiotics, concerns over emerging black box warnings as well as keys to patient education and appropriate, safe prescribing.
Infection and Infection Management - Woundcarelearningnetwork.com
In this video, Paul Kim DPM, MS, discusses infection in daily practice and how clinicians can evaluate infected wounds. He touches on methods for infection detection and management.
Use of topical sevoflurane in pressure ulcer treatment in a double-lung transplant patient - Nih.gov
Abstract by Carolina Hidalgo-Doniga, Candelas Lopez-Lopez, Violeta Pajero Otero, Maria Elena Garcia Manzanares, Laura Collados-Gomez, Ignacio Zaragoza-García, Juana María Aguilar Ortega, Maria Del Valle Garzon Delgado and Santiago Perez Garcia (Madrid, Spain - J Tissue Viability).
Association of Negative Pressure Wound Therapy and Dermatotraction for Management of Necrotizing Soft Tissue Infections: A Case Series - Woundresearch.com
Article by Daniel Aparicio-Sánchez, José Pintor-Tortolero, Eduardo Perea-Del Pozo, Luis Tallón-Aguilar and Francisco Javier Padillo-Ruiz (Sevilla, Spain). Based on the experiences herein, NPWT-D may be a safe and useful alternative surgical treatment for the management of necrotizing STIs. In the present cases, NPWT-D improved and shortened the wound healing process, and it achieved a tertiary wound closure, thereby avoiding the need for skin grafts.
Wearable, portable invention offers options for treating antibiotic-resistant infections, wounds - Purdue.edu
The rapid increase of life-threatening, antibiotic-resistant infections has resulted in challenging wound complications with limited choices of effective treatments. About 6 million people in the United States are affected by chronic wounds.
Now, a team of innovators from Purdue University has developed a wearable solution that allows a patient to receive treatment without leaving home.
Clinical Applications and Benefits of Using Closed-Incision Negative Pressure Therapy for Incision and Surrounding Soft Tissue Management: A Novel Approach for Comorbid Wounds - Nih.gov
Abstract by Treesa W Gomez, Justus W Gomez and Rajesh Gopal (India, Abu Dhabi - Cureus).
Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation - Nih.gov
Abstract by Lin Mao, Sanming Hu, Yihua Gao, Li Wang, Weiwei Zhao, Lina Fu, Haoyan Cheng, Lin Xia, Shangxian Xie, Weiliang Ye, Zhijun Shi and Guang Yang (China - Adv Healthc Mater.).
pdf (0,99 mB)!
Scaffolds for Wound Healing Applications - Mdpi.com
Article by Irina Negut, Gabriela Dorcioman and Valentina Grumezescu (Magurele, Romania - Polymers).
Nowadays, there are still many problems encountered by healthcare professionals with the growing number of patients with microbial infections, wounds, and burns. The next generation of wound healing scaffolds will involve the use of theranostic materials that
will combine interactive and bioactive means together with therapeutic and diagnostic functionality into a single scaffold. It is envisioned that new technologies will integrate target biomarkers into
scaffolds to monitor wound healing.
Moist Wound Healing with Commonly Available Dressings - Nih.gov
Abstract by Kristo Nuutila and Elof Eriksson (Boston, USA - Adv Wound Care (New Rochelle)).
Management of post-surgical wounds in general practice - Nih.gov
Abstract by Sankar Sinha (Australia - Aust J Gen Pract.).
The biomechanical efficacy of a dressing with a soft cellulose fluff core in prophylactic use - Nih.gov
Abstract by Amit Gefen, Maja Krämer, Maik Brehm and Sören Burckardt (Israel, Germany - Int Wound J.).
A Prospective Randomized Study: The Usefulness and Efficacy of Negative Pressure Wound Therapy with Lipidocolloid Polyester Mesh Compared to Traditional Negative Pressure Wound Therapy for Treatment of Pressure Ulcers - Nih.gov
Abstract by Wooyeol Baek, Nara Lee, Eun Jin Han, Tai Suk Roh and Won Jai Lee (Seoul, Korea - Pharmaceutics).
Retained negative pressure wound therapy foams as a cause of infection persistence - Nih.gov
Abstract by Konstantinos Anagnostakos, Andreas Thiery and Ismail Sahan (Saarbrucken, Germany - Adv Wound Care (New Rochelle)).
Treatment of Hard-to-heal Diabetic Foot Ulcers With a Hepatic-derived Wound Matrix - Woundresearch.com
Article by Robert Fridman, Payam Rafat, Carl C. Van Gils, Deena Horn, Dean Vayser and C. Jake Lambert, Jr (Wonds). The HD-WM under evaluation did well at closing difficult-to-heal wounds with minimal applications. These results are consistent with a previous study on this HD-WM.
Wound Phototherapy - Woundresearch.com
Article by Laura L. Bolton. Researchers have tested the effects of low-level light therapy (LLLT) using low-power lasers or non-coherent, non-collimated light therapy from light-emitting diodes (LEDs) on wounds for decades, exploring the efficacy of phototherapy treatments for chronic and acute wounds.
Skin Failure Clinical Indicator Scale: Proposal of a Tool for Distinguishing Skin Failure From a Pressure Injury - Woundresearch.com
Article by Richard Hill and Amy Petersen (Wounds). The proposed scale may provide a means to correctly recognize and diagnose skin failure, initiate appropriate interventions, and decrease potential reimbursement penalties to facilities. Further testing will be necessary in order to validate the specificity and selectivity of this instrument.
A Novel Approach to Limb Salvage: Healing Transmetatarsal Amputations Without A Viable Plantar Flap - Nih.gov
Abstract by Janell J Holloway, Kimberly Lauer, Nikhil Kansal, Frederic Bongard and Ashley Miller (USA - Ann Vasc Surg.).
The Effect of Cold Water on Pain Evaluation During Negative Pressure Wound Therapy Dressing Changes: A Prospective, Randomized Controlled Study - Nih.gov
Abstract by Suphot Chattinnakorn, Poonpissamai Suwajo, Jiraroch Meevassana, Kasama Nilprapha, Pornthep Pungrasmi, Pasu Promniyom, Seree Iamphongsai, Sirachai Jindarak and Apichai Angspatt (Bangkok, Thailand - Int J Low Extrem Wounds).
Use of compression therapy to treat lower limb wounds across Europe: a scoping review protocol - Bmj.com
Article by Ray Samuriwo, Natalia Christiansen and Alison Hopkins (UK, Denmark - BMJ Open). The aim of this scoping review is to map the evidence published in English relating to the use of compression therapy to treat lower limb wounds across Europe.
Anti-staphylococcal hydrogels based on bacterial cellulose and the antimicrobial biopolyester poly(3 - hydroxy - acetylthioalkanoate - co - 3 - hydroxyalkanoate) - Sciencedirect.com
Article by Virginia Rivero-Buceta, María Rosa Aguilar, Ana María Hernández-Arriaga, Francisco G. Blanco, Antonia Rojas, Marta Tortajada, Rosa Ana Ramírez-Jiménez, Blanca Vázquez-Lasa and Auxiliadora Prieto (Spain - International Journal of Biological Macromolecules).
The hydrogel composition PHACOS20 is selected as the best candidate formulation and proposed for further developments in wound healing applications.
Long-Lasting Wound Infections Linked to Microbes and Genetics - The-scientist.com
Article by Lisa Winter. How quickly scrapes, cuts, and gashes in the skin heal can vary greatly depending on a person’s body mass, age, and whether the individual suffers from certain chronic conditions such as diabetes. Genetics, a new study suggests, may also play a role, with variations in two specific genes lowering the diversity of a wound’s microbiome and lengthening healing time.
Plantar Foot Ulcer Recurrence in Neuropathic Patients Undergoing Percutaneous Tendo-Achilles Lengthening - Nih.gov
Abstract by Dean H Meshkin, Kevin K Ragothaman, Jessica Arneson, Cara K Black, Nicole C Episalla, Elliot T Walters, Karen K Evans, John S Steinberg, Christopher E Attinger and Paul J Kim (Washington, USA - J Foot Ankle Surg.).
Measurement of wound area for early analysis of the scar predictive factor - Scielo.br
Article by Adriano Antonio Mehl (Curitiba, Brazil - Rev. Latino-Am. Enfermagem). The 2D-FlexRuler is a reliable metric platform for obtaining the image of the anatomical limits of chronic wounds. It facilitates the calculation of the area of the wound under monitoring, which allowed to obtain the scar predictive factor of chronic wounds with precocity, in two weeks, with more accurate results than those obtained with traditional methods.
The role of topical probiotics on wound healing: A review of animal and human studies - Wiley.com
Abstract by Rebecca Knackstedt, Thomas Knackstedt and James Gatherwright (International Wound Journal).
Efficacy of alginate-and chitosan-based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review - Nih.gov
Abstract by Hong Cai and Guichen Li (China - Wound Repair Regen.).
Predictors of pressure injury development in critically ill adults: A retrospective cohort study - Nih.gov
Abstract by Jennifer J Sala, Anoop Mayampurath, Susan Solmos, Susan C Vonderheid, Marianne Banas, Alexandria D'Souza and Cynthia LaFond (USA - Intensive Crit Care Nurs.).
Management of Grade IV Pressure Ulcers With a Novel Negative Pressure Device in Traumatic Paraplegia Subjects - Nih.gov
Abstract by Mukesh K Dwivedi, Amit BhagatRajeshwar N Srivastava and Lavini Raj (India, USA - Cureus).
HS-TIME: A Modified TIME Concept in Hidradenitis Suppurativa Topical Management - Woundresearch.com
Article by Teresa Oranges, Agata Janowska, Andrea Chiricozzi, Marco Romanelli and Valentina Dini (Pisa, Italy - Wounds).
Considering the lack of strong evidence regarding wound care in HS, the authors propose a new concept of TIME, which differentiates between the typical HS lesion approach and postsurgical wound approach. As a new, easy-to-use, helpful tool, HS-TIME may assist physicians in identifying the best wound care approach to improve outcomes in patients with HS.
Negative Pressure Wound Therapy With Flap Reconstruction for Extensive Soft Tissue Loss in the Foot: A Case Report - Cureus.com
Article by Kishore Vellingiri, Nagakumar J. S. and Deepak Hongaiah (Cureus). The patient in this case report had better clinical and functional outcomes following NPWT for extensive soft tissue loss in the foot. NPWT is relatively a safer technique with less chance of infection than traditional dressing methods. The authors' hypothesis is that wound debridement followed by a single set of VAC placement for seven days should be tried for wound needing soft tissue coverage. Hence, it is a feasible and valuable method in the treatment of compound fractures with massive soft tissue defects.
Negative pressure wound therapy for patients with mediastinitis: A meta-analysis - Nih.gov
Abstract by Zhi Wang, Cheng Feng and Xiao-Jun Wang (Beijing, China - Int. Wound J.).
Increasing Transcutaneous Oxygen Pressure in Patients With Neuroischemic Diabetic Foot Ulcers Treated With a Sucrose Octasulfate Dressing: A Pilot Study - Nih.gov
Abstract by José Luis Lázaro-Martínez, Marta García-Madrid, Josep M García-Alamino, Serge Bohbot, José Luis García-Klepzig and Yolanda García-Álvarez (Spain, France - Int J Low Extrem Wounds).
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