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News from the field of wound care and wound healing - October, 2022

P311 promotes IL-4R-mediated M2 polarization of macrophages to enhance angiogenesis for efficient skin wound healing - PubMed
Abstract by Cheng Chen, Yuanyang Tang, Xudong Zhu, Jiacai Yang, Zhihui Liu, Yunxia Chen, Jue Wang, Ruoyu Shang, Wenxia Zheng, Xiaorong Zhang, Xiaohong Hu, Jianglin Tan, Junyi Zou, Shiya Peng, Qudong Lu, Zhenyu Ju, Gaoxing Luo and Weifeng He (China - J Invest Dermatol.).


An interesting case report of cutaneous tuberculosis of the foot - PubMed
Abstract by C Tharun Ganapathy, Nidhi Mariam George, Sundeep Selvamuthukumaran, Preetam Anguraj and Amit Gilani (India - Int J Surg Case Rep.).


Phototherapy of Pseudomonas aeruginosa-Infected Wounds: Preclinical Evaluation of Antimicrobial Blue Light (450-460 nm) Using In Vitro Assays and a Human Wound Skin Model - PubMed
Abstract by Marie-Charlotte D Leder, Mahsa Bagheri, Isabell Plattfaut, Paul C Fuchs, Anne K E Brüning, Jennifer L Schiefer and Christian Opländer (Germany - Photobiomodul Photomed Laser Surg.).


Beneficial Effects of Oleosomes Fused with Human Fibroblast Growth Factor 1 on Wound Healing via the Promotion of Angiogenesis - Mdpi.com
Article by Yongxin Guo, Guodong Chu, Weijia Cai, Yaying Li, Xinxin Lan, Jing Li, Linna Du and Jing Yang (Changchun, China - IJMS). The authors' results showed that the number, length and branches of the blood vessels of the chick embryo chorioallantoic membrane were markedly increased after OLAF treatment.


Characterization and modeling of partial-thickness cutaneous injury from debris-simulating kinetic projectiles - Nature.com
Article by Christopher A. Berkey, Omar Elsafty, Montanna M. Riggs and Reinhold H. Dauskardt (Stanford, USA - Communications Engineering). The authors quantitatively characterize damage in near-live human skin after impact by debris-simulating kinetic projectiles at differing impact angles and energies. Impact events are monitored using high-speed and quantitative imaging to visualize skin injuries.


A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera - Cureus.com
Article by Nicole J. Levin, Young Erben, Yupeng Li, Tara J. Brigham and Alison J. Bruce. Increased consideration and emphasis should be placed on using Aloe vera to aid the healing of second- and third-degree burns.


Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing - Nature.com
Article by Xue Liu, Rebecca Barresi, Michael Kaminer, Kun Qian, Fabienne Thillou, Michel Bataillon, I-Chien Liao, Qian Zheng and Charbel Bouez (USA, France - Scientific Reports). This is one of the first works to date that utilizes microneedled ex vivo skin to demonstrate its regenerative behavior. The authors' model recapitulates the main features of the microneedling treatment and enables the evaluation of future cosmetic active ingredients used in conjunction with microneedling.


Comparison of Long-Term Skin Quality and Scar Formation in Partial-Thickness Burn Wounds Treated with Suprathel® and epicitehydro® Wound Dressings - Mdpi.com
Article by Jennifer Lynn Schiefer, Friederike Genoveva Aretz, Paul Christian Fuchs, Rolf Lefering, Pouyan Yary, Christian Opländer, Alexandra Schulz and Marc Daniels (Germany - Medicina). Both the newer and less expensive wound-dressing epicitehydro® and the well-known wound-dressing Suprathel® resulted in stable wound closure and showed good cosmetic results in the follow-up examinations.


Utilization of ex vivo tissue model to study skin regeneration following microneedle stimuli - Mdpi.com
Article by Yishu Yan, Panpan Ren, Qingqing Wu and Tianmeng Zhang (China - Biomolecules). The authors' results indicated that the addition of the microgel as a new crosslinker created flexibility during the construction of the alginate hydrogel, adapting for diverse applications during diabetic-induced wound therapy.


Computerised prediction of healing for venous leg ulcers - Nature.com
Article by Quoc Cuong Ngo, Rajna Ogrin and Dinesh Kant Kumar (Australia - Scientific Reports). In this paper, the authors propose a framework for computerised prediction of healing for venous leg ulcers assessed in home settings using thermal images of the 0 week.


Increased Population of CD40+ Fibroblasts Is Associated with Impaired Wound Healing and Chronic Inflammation in Diabetic Foot Ulcers - Mdpi.com
Article by Joshua Patrick Bungalon Littig, Rebecca Moellmer, Adrienne M. Estes, Devendra K. Agrawal and Vikrant Rai (Pomona, USA - JCM). The authors' results revealed significantly increased density of CD40+ fibroblasts and differential expression of mediators of inflammation in DFU tissues compared to clean tissue.


Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat - Plos.org
Article by Yu-Hsuan Cheng ,Hung-Keng Li ,Chien-An Yao, Jing-Ying Huang, Yi-Ting Sung, Shiu-Dong Chung and Chiang-Ting Chien (Taiwan - Plos One). The authors suggest that NAIs conferred a protection through the upregulating LC3-II-dependent autophagy mechanism and downregulating leukocyte infiltration mediated inflammation and caspase 3/Poly-ADP-ribose-polymerase signaling in the LPS-treated ALI and promoted diabetic wound healing through the enhancing skin collagen synthesis, VEGFR-2 and TGF-β1 pathways.


Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review - PubMed
Abstract by Sonali Sharma, Allyson R Alfonso, Alex J Gordon, Jennifer Kwong, Lawrence J Lin and Ernest S Chiu (New York, USA - Adv Skin Wound Care).


Effect of Nursing Intervention on Promoting Healing of RW in Patients with Diabetic Foot: A Systematic Review and Meta-Analysis - PubMed
Abstract by Huan Chen, Xiaoxia Lv and Yingying Zhang (Huzhou, China - Comput Math Methods Med.).


Preventive Measures For pressure injuries: structure of social representations of nursing teams - PubMed
Abstract by Rosa Maria Ferreira de Almeida, Luiz Fernando Rangel Tura and Rafael Celestino da Silva (Rio de Janeiro, Brazil - Rev Esc Enferm USP).


Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight - Springer.com
Article by Farmiza Begum, Suman Manandhar, Gautam Kumar, Raghuvir Keni, Runali Sankhe, Prasada Chowdari Gurram, Fathima Beegum, Meka Sai Teja, Krishnadas Nandakumar and Rekha R. Shenoy (Manipal, India - Journal of Cell Communication and Signaling). DHZ significantly accelerates the healing of diabetic foot ulcers in high fat diet fed plus low dose streptozotocin induced type-II diabetic Wistar rats.


Enhanced Diabetic Wound Healing Using Electrospun Biocompatible PLGA-Based Saxagliptin Fibrous Membranes - Mdpi.com
Article by Chen-Hung Lee, Shu-Chun Huang, Kuo-Chun Hung, Chia-Jung Cho and Shih-Jung Liu (Taiwan - Nanomaterials). The electrospun PLGA-based saxagliptin membranes exhibited excellent biomechanical and biological features that enhanced diabetic wound closure and increased the antioxidant activity, cellular granulation, and functionality.


Venous Leg Ulcers: Potential Algorithms of Care - Hmpgloballearningnetwork.com
Article by Crystal V. James, Quinn Murray, So Youn Park, Nazanin Khajoueinejad, Jani Lee, Keval Ray and John C. Lantis II. This review presents a systematic approach to management of VLUs based on previous literature and the authors’ clinical experience, with consideration given to wound size, etiology, and responses to prior treatment. Techniques described include debridement (autolytic, enzymatic, sharp/surgical), compression therapy, physical therapy, medical adjuncts, and cellular- and tissue-based therapy.


How Might a Posterior Splint Method Improve Offloading Outcomes? - Woundsource.com
Article by Shannon Solley. Is there an irremovable offloading device suitable for lower extremity pressure injuries? "An irremovable heel offloading device encourages increased compliance,” says Dr. Lenz and Dr. Hussain within their poster presentation at SAWC, “Heel Offloading Posterior Splint for Treatments of Heel Ulcerations."


A Closer Look at Health Literacy Disparities in Wound Care Education - Woundsource.com
Article by Hannah Fell. How should clinicians best educate their patients and increase adherence? Wound care professionals should take into account patient reading level when providing care instructions, among other factors.


Antibiotic Time-Outs: Strategies for Reducing Incidences of Antimicrobial Resistance - Woundsource.com
Antibiotics have been a source of increasing concern and subsequent regulation among providers, especially those within wound care. Antimicrobial stewardship has been emphasized within the medical system in recent years as antibiotic-resistant organisms have increased globally and among at-risk patient populations. Antibiotic time-outs have been a recent and successful approach to tackling this concern. They have resulted in better patient outcomes and lower incidences of antimicrobial resistance (AMR) infection in the health care setting.


Cocos nucifera L. endosperm promotes healing of excised wound in BALB/c mice - Acarindex.com
Abstract by Erna C. Arollado, Leslie B. Tomagan, Kerstin Mariae G. Ponsaran, Richelle Ann M. Manalo, Gerwin Louis T. Dela Torre, Arlene A. Samaniego, Rohani B. Cena and Josephine D. Agapito (Marmara Pharmaceutical Journal).


Comparative effectiveness of heel-specific medical devices for the prevention of heel pressure ulcers: A systematic review - PubMed
Abstract by Clare Greenwood, E Andrea Nelson, Jane Nixon, Armando Vargas-Palacios and Elizabeth McGinnis (UK - J Tissue Viability).


On-Demand Changeable Theranostic Hydrogels and Visual Imaging-Guided Antibacterial Photodynamic Therapy to Promote Wound Healing - PubMed
Abstract by Pan Ran, Huan Zheng, Wenxiong Cao, Xinwei Jia, Guiyuan Zhang, Yuan Liu and Xiaohong Li (Chengdu, China - ACS Appl Mater Interfaces).


Healthcare interventions to aid patient self-management of lower limb wounds: A systematic scoping review - Mdpi.com
Article by Layla Bolton Saghdaoui, Smaragda Lampridou, Simona Racaru, Alun Huw Davies and Mary Wells (International Wound Journal). The objective of this systematic scoping review was to define what the self-management of a lower limb wound entails and explore the interventions available to support patients to self-manage.


Graphene oxide accelerates diabetic wound repair by inhibiting apoptosis of Ad-MSCs via Linc00324/miR-7977/STK4 pathway - Mdpi.com
Article by Zhe Ji, Jian Wang, Shuai Yang, Shengjun Tao, Caiqi Shen, Hanxiao Wei, Qiang Li and Peisheng Jin (The FASEB Journal). The authors' findings suggest GO may be a superior auxiliary material for Ad-MSCs to facilitate diabetic wound healing via the Linc00324/miR-7977/STK4 pathway.


Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing - Mdpi.com
Article by Jingbo Zhang, Xiang Qu, Junjun Li, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Yoshiki Sawa, Li Liu and Shigeru Miyagawa (Osaka, Japan - IJMS). The authors' findings suggest that hUC-MSCs cultured on PLGA scaffolds improve diabetic wound healing, collagen deposition, and angiogenesis, and provide a novel and effective method for cell transplantation, and a promising alternative for diabetic skin wound treatment.


Effectiveness of four topical treatment methods in a rat model of superficial partial-thickness burn injury: the advantages of combining zinc-hyaluronan gel with silver foam dressing - Injuryjournal.com
Article by Alexandra Csenkey, Emma Hargitai, Eszter Pakai, Bela Kajtar, Livia Vida, Aba Lorincz, Marin Gergics, Peter Vajda, Gergo Jozsa and Andras Garami (Pecs, Hungary - Injury). The authors designed and histologically confirmed a reproducible method for induction of superficial partial-thickness burns in rats for preclinical testing. In their model, the combination of zinc-hyaluronan gel with silver foam dressing was more effective than either of its components alone or than silver-sulfadiazine cream.


Comparative assessment of commercially available wound gels in ex vivo human skin reveals major differences in immune response-modulatory effects - PubMed
Abstract by S Seiser, D Cerbu, A Gallhofer, J Matiasek and A Elbe-Bürger (Vienna, Austria - Sci Rep.).


Wound care in the geriatric client - Tandfonline.com
Article by Steve Gist, Iris Tio-Matos, Sharon Falzgraf, Shirley Cameron and Michael Beebe (Tacoma, USA - Clinical Interventions in Aging). Types of ulcers include pressure ulcers, vascular ulcers (arterial and venous hypertension), and neuropathic ulcers. Treatment of these ulcers involves recognizing the four stages of healing: coagulation, inflammation, proliferation, and maturation.


A cross-sector systematic review and synthesis of knowledge on telemedicine interventions in chronic wound management – Implications from a system perspective - Wiley.com
Article by Sindre Aske Høyland, Kari Anne Holte, Kamrul Islam, Olaug Øygaarden, Egil Kjerstad, Synnøve Aske Høyland, Hanne Rusten Wærnes, Marcus Gürgen, Katharina Brekke Conde, Kristin Søisdal Hovland, Eirin Rødseth, Pascale Carayon, Maureen Fallon, Nicola Ivins, Sarah Bradbury, Sissel Iren Eikeland Husebø, Keith G. Harding and Thomas Ternowitz (International Wound Journal). Of practical consideration, the authors suggest that the design and execution of TM improvement interventions and associated research projects should be conducted in close cooperation with managers and practitioners knowledgeable about barriers and opportunities that can influence the implementation of important interventions within chronic wound management.


Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model - Mdpi.com
Article by Hairul-Islam Mohamed Ibrahim, Muthukumar Thangavelu and Ashraf Khalifa (Saudi Arabia, Korea, Egypt - Molecules). CHDs-HPW exhibited a significant reduction in inflammation and inflammatory markers and helped to obtain a faster wound-healing process in a mouse model.


Barriers and facilitators to reporting medical device-related pressure ulcers: A qualitative exploration of international practice - PubMed
Abstract by Ewa A Crunden, Peter R Worsley, Susanne B Coleman and Lisette Schoonhoven (UK, The Netherlands - Int J Nurs Stud.).


Nanotechnology-Based Dressings for Wound Management - Mdpi.com
Article by Janaína A. Ataide, Beatriz Zanchetta, Érica M. Santos, Ana Laura M. Fava, Thais F. R. Alves, Letícia C. Cefali, Marco V. Chaud, Laura Oliveira-Nascimento, Eliana B. Souto and Priscila G. Mazzola (Brazil, Portugal - Pharmaceuticals). This review aims to summarize the healing process phases and provide a general overview of dressings based in nanotechnology using biomaterials for the release of active agents in wound site.


Emerging Technologies in the Wound Management Field - PubMed
Abstract by George Marzloff, Stephanie Ryder, Jennifer Hutton, Kaila Ott, Mallory Becker and Scott Schubert (USA - Phys Med Rehabil Clin N Am.).


The effect of inflammation management on pH, temperature, and bacterial burden - Wiley.com
Article by Rosemarie Derwin, Declan Patton, Helen Strapp and Zena Moore (Ireland - International Wound Journal). This study demonstrated that it was feasible to practice inflammation management using a structured approach to enhance wound outcomes.


Impact of negative pressure wound drainage compared with natural wound drainage after thyroid tumour surgery: A meta-analysis - Wiley.com
Article by Mohamed S. Imam, Randa M. Abdel-Sattar, Amr S. Alamri, Abdullah M. Alqurashi, Ahmed M. Amer Alnefaie and Mohamed E. A. Abdelrahim (Saudi Arabia - International Wound Journal). Those who used negative pressure wound drainage had significantly higher averages of drained material, shorter drain placement times, lower rates of wound infection at the surgical site, higher rates of wound healing, and lower rates of wound seroma.


Cutaneous/Mucocutaneous Leishmaniasis Treatment for Wound Healing: Classical versus New Treatment Approaches - Mdpi.com
Article by Patrícia Severino, Wanessa Santana, Erika S. Lisboa, Victoria L. S. dos Santos, Erica T. dos Santos Lima, Juliana C. Cardoso, Ricardo L. C. de Albuquerque-Junior, Beatriz C. Naveros, Antonello Santini, Eliana B. Souto and Sona Jain (Brazil, Spain, Italy, Portugal - Microbiology Research). In this review, the authors discuss the advantages and limitations of using topical drug delivery for the treatment of two forms of leishmaniasis and the relevance of combining this approach with other pharmaceutical dosage forms.


The impact of prophylactic negative pressure wound therapy on surgical site infections in pancreatic resection: A systematic review and meta-analysis - PubMed
Abstract by Tori Lenet, Richard W D Gilbert, Jad Abou-Khalil, Fady K Balaa, Guillaume Martel, Alexandre Brind'Amour and Kimberly A Bertens (Ottawa, Canada - HPB (Oxford)).


The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review - Mdpi.com
Article by Yanying Wang, Jiayan Zhu, Jing Chen, Ruojiao Xu, Thomas Groth, Haitong Wan and Guoying Zhou (China, Germany - CIMB). The authors' results show that exosomes could regulate these signaling pathways to down-regulate inflammation, reduce oxidative stress, increase angiogenesis, promote fibroblast proliferation, induce re-epithelization and inhibit scar formation, making exosomes attractive candidates for the treatment of diabetic wounds.


The effect of photomodulation on fibroblast growth factor and the Ras/MAPK signalling pathway: a review - PubMed
Abstract by Patricia Kasowanjete, Nicolette N Houreld and Heidi Abrahamse (Johannesburg, South Africa - J Wound Care).


An experimental study for assessing the wound healing potential and for calculating the median effective concentration (EC50) of deferoxamine in diabetic wistar albino rats - Thepharmajournal.com
Article by Abdul Sadam, Madhuri Patel, Sanjay Kumawat, W Ramdas Singh, Anshuk Sharma, Aneesha VA, Madhu CL, Dinesh Kumar and Jafarsab (India). In the present study, a greater wound contraction, considerable reduction in wound size and significantly higher content of hydroxyproline and glucosamine levels in DFO-treated groups compared to control group suggests that DFO have accelerated the diabetic wound healing process by promoting collagen synthesis and deposition in ECM.


Acceleration of Wound Healing in Rats by Modified Lignocellulose based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles - Healthifyme.com
Article by Pooya Dehghani, Aliakbar Akbari, Milad Saadatkish, Jaleh Varshosaz, Monireh Kouhi and Mahdi Bodaghi (Iran, UK - Gels). The in vivo assessment of the developed sponge asserts its suitability as wound dressing for treatment of chronic skin wounds.


Soluble chitosan derivative treats wound infections and promotes wound healing in a novel MRSA-infected porcine partial-thickness burn wound model - Plos.org
Article by Francesco Egro, Alex Repko, Vidya Narayanaswamy, Asim Ejaz, Deokyeol Kim, M. Asher Schusterman, Allister Loughran, Ali Ayyash, Stacy M. Towsend, Shenda Baker, Jenny Ziembicki, Kacey Marra and Peter Rubin (Plos One). The data demonstrate the potential of the wound rinse/gel to significantly enhance healing, promote re-epithelialization, and reduce bacterial burden in infected PTBW using an economical porcine model.


Impaired wound healing in diabetes - Magonlinelibrary.com
Abstract by Laura Swoboda and Jessica Held (Journal of Wound Care).


Healing Foods for Post-Surgical Recovery or Wound Healing - Healthifyme.com
Article by Hiral Patel. This article provides foods that are scientifically proven to be beneficial for wound care. Incorporating these few foods that are listed below promotes rapid wound healing.


Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing - Mdpi.com
Article by Tayyaba Sadiq, Syed Haroon Khalid, Ikram Ullah Khan, Hira Mahmood and Sajid Asghar (Faisalabad, Pakistan - Gels). In light of the obtained results, the higher potential of the optimized biocomposite hydrogel film for wound healing applications was corroborated.


Negative Pressure Wound Therapy Promotes Wound Healing by Inhibiting Inflammation in Diabetic Foot Wounds: A Role for NOD1 Receptor - PubMed
Abstract by Tao Wang, Longhua Fan, Jianjun Liu, Yue Tao, Xu Li, Xiaojun Wang and Limeng Li (Shanghai, China - Int J Low Extrem Wounds).


The Wound Microbiome - PubMed
Abstract by Ellen K White and Elizabeth A Grice (Pennsylvania, USA - Cold Spring Harb Perspect Biol.).


Skin Grafting, Cryopreservation, and Diseases: A Review Article - Cureus.com
Article by Mohammad Adnan, Roshan K. Jha, Priyanshu Verma, Harsh N. Shah and Parth Singh. This study looks at how the stratum corneum's molecular and macroscopic characteristics interact and change with skin wetness. Although there is little information written about them and even less is understood about them, moisturizers are a crucial component of a dermatologist's toolkit.


Injectable allograft adipose matrices in the management of chronic and postoperative wounds: a retrospective analysis - PubMed
Abstract by Joshua P Weissman, Matthew D Ramsey, Peter J Ullrich, Chitang J Joshi, Stuti Garg and Robert D Galiano (Chicago, USA - Wounds).


Atypical ulcers: a stepwise approach for clinicians - PubMed
Abstract by Melissa A Nickles, Maria M Tsoukas, Nadera Sweiss, William Ennis and Igor A Altman (Chicago, USA - Wounds).


Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers - Mdpi.com
Article by Ermelindo Carreira Leal and Eugenia Carvalho (Coimbra, Portugal - IJMS). Therapeutic strategies involving the activation of HO-1, or the topical application of its biologically active end products are important in diabetic wound healing. Therefore, HO-1 is an attractive therapeutic target for DFU treatment.


Development of Nanoemulsions for Wound Dressings Containing Cassia alata L. Leaf Extraction - Hindawi.com
Article by Surat Sangkaew, Smith Wanmasae, Kingkan Bunluepeuch, Tassanee Ongtanasup, Siriwan Srisang, Chawan Manaspon, Philaslak Pooprommin and Komgrit Eawsakul (Thailand - Evidence-Based Complementary and Alternative Medicine). The purpose of this research was to use ionic crosslinking to improve the mechanical characteristics, absorption of fluid in the wound, and drug release behavior of Cassia alata L. extract loaded niosomes that were incorporated in an alginate-pectin film.


Pressure injury screening in the emergency department: A concept analysis - PubMed
Abstract by Laura Ogle, Mikel W Hand and Constance Swenty (Evansville, USA - Nurs Forum).


Traditional Chinese medicine for hypertrophic scars – A review of the therapeutic methods and potential effects - Frontiersin.org
Article by Daqin Chen, Qiannan Li, Huimin Zhang, Fang Kou, Qiang Li, Chunming Lyu and Hai Wei (Shanghai, China - Front. Pharmacol.). This paper reviews the formation process of hypertrophic scar, the therapeutic strategy for hypertrophic scar, the research progress of TCM with its relevant mechanisms in the treatment of hypertrophic scar, and the related new drug delivery system of TCM, aiming to provide ideas for further research of botanical compounds in the treatment of hypertrophic scar.


Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs - Hindawi
Article by Julan Guo, Yuxing Huang, Bojun Xu and Jiao Yang (Chengdu, China - Computational and Mathematical Methods in Medicine). A previous meta-analysis has revealed that cold atmospheric plasma (CAP) might not be clinically beneficial to chronic wounds. However, several new randomized controlled trials (RCTs) reported that CAP was an effective treatment option for accelerating wound healing in chronic wounds. The purpose of this review is to incorporate these new results and evaluate the efficacy of CAP in chronic wounds.


The Effectiveness of Chitosan Wound Dressing in the Form of a Film Compared to Its Hydrogel on Burn Wound Healing in the Male Wistar Rat Model - Hindawi
Article by Seyed Amin Mousavinezhad, Nasser Harzandi , Azam Marjani and Parvaneh Jafari (Iran - J Police Med). Considering the ease of application and maintenance of the film form and better control of inflammation, it seems that the film form is preferable to the hydrogel.


Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review - Mdpi.com
Article by Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop and Mh Busra Fauzi (Malaysia - Polymers). In this article, a simple review compromising the evaluation of silicon’s unique properties has been discussed and followed by the application of the silicone-based product in future perspectives in biomedical fields.


IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells - Nature.com
Article by Juan Wang and Xiaolei Ding (China - Signal Transduction and Targeted Therapy). Inflammatory signals determine many aspects of tissue repair and regenerative processes, and their dysregulation frequently results in aberrant inflammatory responses and subsequent failure in re-epithelization. Both are key features of slow or non-healing skin ulcers, which are a growing health concern worldwide.


Applications of acellular human amniotic membrane in regenerative medicine - PubMed
Abstract by Shaghayegh Doudi, Mansoureh Barzegar, Elham Angouraj Taghavi, Mohammad Eini, Arian Ehterami, Karen Stokes, Jonathan S Alexander and Majid Salehi (USA, Iran, Switzerland - Life Sci.).


Going Back to Basics While Incorporating Technological Advances in Wound Management - Woundsource.com
Article by Holly Hovan. Taking it back to basics is vital, but do not forget that the health care field is constantly evolving, and there are always new things to be learned. Incorporating the basics, our senses, and new and different approaches to wound management (telemedicine, photography) will likely result in improved patient outcomes and increased access to care.


Identifying the Different Types of Wound Drainage - Woundsource.com
As health care professionals monitor the wound drainage of a patient, it is critical to be able to recognize the different types of wound drainage. Open wounds and incision wounds may both present varying types of exudate, some of which are perfectly healthy and others that can signal an infection or slow healing. Identifying wounds that need a change in care can speed the healing process.


Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin - PubMed
Abstract by Svetolik Maksimovic, Milica Stankovic, Sonja Roganovic, Ivana Nesic, Jelena Zvezdanovic, Vanja Tadic and Irena Zizovic (Serbia, Poland - J Ethnopharmacol.).


Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing - Mdpi.com
Article by Mengfan Wu, Dany Y. Matar, Zhen Yu, Ziyu Chen, Samuel Knoedler, Brian Ng, Oliver A. Darwish, Sadaf Sohrabi, Leigh Friedman, Valentin Haug, George F. Murphy, Yuval Rinkevich, Dennis P. Orgill and Adriana C. Panayi (China, USA - Pharmaceutics). In this study, the authors investigate the impact of micromechanical forces exerted through negative pressure wound therapy (NPWT) on the pathophysiology of fibrosis.


Effect of platelet-rich fibrin (PRF) membranes on the healing of infected skin wounds - Springer.com
Abstract by Bruno Botto Barros Silveira, Lucas Novaes Teixeira, Richard J. Miron and Elizabeth Ferreira Martinez (Archives of Dermatological Research).


Effectiveness of electrophysical agents for treating pressure injuries: a systematic review - PubMed
Abstract by Aline Santos Vieceli, Juruciara Cristiano Martins, Ketlyn Germann Hendler, Ana Paula Tavares Santos, Lais Mara Siqueira das Neves, Rafael Inacio Barbosa, Heloyse Uliam Kuriki and Alexandre Marcio Marcolino (Araranguá, Brazil - Lasers Med Sci.).


The Efficacy of Honey Compared to Silver Sulfadiazine for Burn Wound Dressing in Superficial and Partial Thickness Burns – A Systematic Review and Meta-Analysis - Mdpi.com
Article by Samatar Osman, Hamza Umar, Yousuf Hashmi, Anam Jawaid and Zubair Ahmed (Birmingham, UK - Trauma Care). The authors conclude that honey dressings may be as or more effective than SSD in the treatment of superficial and partial thickness burn injuries.


Patient experience of negative pressure wound therapy: A qualitative study - PubMed
Abstract by Aiko Miyanaga, Toru Miyanaga, Keiko Sakai, Chizuko Konya, Kimi Asano and Kenichi Shimada (Japan - Nurs Open).


MR-based quantitative measurement of human soft tissue internal strains for pressure ulcer prevention - PubMed
Abstract by Alessio Trebbi, Ekaterina Mukhina, Pierre-Yves Rohan, Nathanaël Connesson, Mathieu Bailet, Antoine Perrier and Yohan Payan (France - Med Eng Phys.).


A Host-Directed Approach to the Detection of Infection in Hard-to-Heal Wounds - Mdpi.com
Article by Michael Burnet, Daniel G. Metcalf, Scarlet Milo, Clemens Gamerith, Andrea Heinzle and Eva Sigl (Germany, UK, Austria, The Netherlands - Diagnostics). The detection of innate immune cell enzymes in hard-to-heal wounds at point of care offers a new, simple, and effective approach to determining wound infection status and may offer significant advantages over uncertainties associated with clinical judgement, and the questionable value of wound microbiology.


Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers - Frontiersin.org
Article by Sen Tong, Qingyu Li, Qiaoyan Liu, Bo Song and Junzi Wu (China - Front. Bioeng. Biotechnol.). This paper reviews the latest progress of delivery systems based on nanocomposite hydrogels in promoting diabetic ulcer healing. Through a review of the recent literature, we put forward the shortcomings and improvement strategies of nanocomposite hydrogels in the treatment of diabetic ulcers.


UCalgary researchers discover common body fluid may help improve wound healing - Ucalgary.ca
Article by Joe McFarland. A bodily fluid known primarily as a lubricant for joints may hold a key for rehabilitating scars and improving wound healing. Proteoglycan 4 (PRG4), also known as lubricin, is a glycoprotein found in humans and throughout the animal kingdom that reduces friction between articulating surfaces like cartilage.


Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment - Biomedcentral.com
Article by Khatereh Khorsandi, Reza Hosseinzadeh, HomaSadat Esfahani, Kavosh Zandsalimi, Fedora Khatibi Shahidi and Heidi Abrahamse (Iran, USA - Inflammation and Regeneration). This review summarizes the functions of reactive oxygen species (ROS) in living systems and describes role of photodynamic therapy in production of controllable ROS and finally a special focus on current ROS-generating therapeutic protocols for regeneration and wound healing.


Topical administration of Juglans regia L. leaf extract accelerates diabetic wound healing - Biomedcentral.com
Article by Davood Nasiry, Ali Reza Khalatbary, Alireza Ghaemi, Mohammad Ali Ebrahimzadeh and Mohammad Hossein Hosseinzadeh (Sari, Iran - BMC Complementary Medicine and Therapies). Topical administration of Juglans regia L. leaf extract, especially in 5% concentration, considerably accelerates diabetic wound healing.


Management of wounds with exposed bone structures using an induced-membrane followed by polymethyl methacrylate and second-stage skin grafting in the elderly with a 3-year follow-up - PubMed
Abstract by Leyi Cai, Zipu Hong, Yingying Zhang, Guangheng Xiang, Peng Luo, Weiyang Gao, Zhijie Li and Feiya Zhou (Wenzhou, China - Int Wound J.).


Failure to Thrive and Wound Care: Malnutrition - Woundsource.com
Article by Heidi Cross. Malnutrition is almost always part of pressure injury lawsuits. It is then important to recognize and document advancing frailty leading to possible Failure to Thrive (FTT), by acknowledging its implications and the reality of the patient’s prognosis and possible outcomes.


Understanding the Braden Scale: Focus on Sensory Perception (Part 1) - Woundsource.com
Article by Holly Hovan. Working with long-term care and geriatric populations opens up a world of multiple pre-existing comorbidities and risk factors that aren’t always explicitly written into the Braden Scale categories. Additionally, the frequency of Braden Scale use may contribute to a multitude of different scores.


Evaluating polymeric biomaterials to improve next generation wound dressing design - PubMed
Abstract by Jacob G Hodge, David S Zamierowski, Jennifer L Robinson and Adam J Mellott (Kansas City, USA - Biomater Res.).


Characterisation of key biomarkers in diabetic ulcers via systems bioinformatics - Wiley.com
Article by Zhan Zhang, Ying Zhang, Dan Yang, Yue Luo, Ying Luo, Yi Ru, Jiankun Song, Xiaoya Fei, Yiran Chen, Bin Li, Jingsi Jiang and Le Kuai (China - International Wound Journal). The authors got the key genes by WGCNA, PPI, and PCR after obtaining the diabetic ulcer gene sets from the datasets GSE37265 and GSE80178. GO terms, KEGG analysis and immune cell infiltration, and immune scores showed that biological functions are closely related to immune response.


Quality of Care and Cost-Effectiveness: Optimizing Wound Care in the Netherlands - PubMed
Abstract by Wouter Brekelmans, Boudewijn L S Borger van der Burg, Nicole J Tolen and Rigo Hoencamp (The Netherlands - Adv Skin Wound Care).


The Sternal Wound Management in Pediatric Cardiac Surgical Patients: Implementation of Wound Care Pathways Incorporating Principles of Wound Bed Preparation Paradigm and Early-Advanced Therapy - PubMed
Abstract by Neerod Kumar Jha, Muhammad Shafique, Raisy Thomas, Salvacion Pangilinan Cruz, Gulnaz Tariq and Laszlo Kiraly (United Arab Emirates - Adv Skin Wound Care).


The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers - Wiley.com
Article by Junglyun Kim, Joyce Stechmiller, Michael Weaver, Daniel J. Gibson, Ann Horgas, Debra L. Kelly and Debra E. Lyon (South Korea, USA - International Wound Journal). To facilitate wound healing, clinicians need to utilise the multifactorial approach, which includes wound treatment and management of symptoms such as pain and fatigue, because of the molecular and psycho-behavioural factors involved in wound healing.


Public Knowledge About How Common Chronic Diseases Affect Wound Healing Postoperatively in Aseer Region - Cureus.com
Article by Muneer J. Bhat, Hussam Y. Ayed, Ali M. Alrasheed, Majdoleen A. Alghamdi, Saud S. Alsaleh, Yazeed M. Alrashid and Saud Bin-fudhayl. This study revealed that more than half of the population in Aseer regions were knowledgeable regarding the effect of chronic diseases on post-operative wound healing, especially for the benefit of a commitment to therapeutic and preventive plans before and after any surgical procedure.


Diversity of Fibroblasts and Their Roles in Wound Healing - PubMed
Abstract by Dongsheng Jiang, Ruiji Guo, Hans-Günther Machens and Yuval Rinkevich (Munich, Germany - Cold Spring Harb Perspect Biol.).


NPWT resource use compared with standard moist wound care in diabetic foot wounds: DiaFu randomized clinical trial results - Biomedcentral.com
Article by Dörthe Seidel, Rolf Lefering and DiaFu study group (Köln, Germany - Journal of Foot and Ankle Research). Resource use was lower for NPWT, which may be an efficient treatment alternative to and standard moist wound care for diabetic foot wounds, to be demonstrated in subsequent cost analyses.


Validation of a Manual Negative Pressure Wound Therapy Device (PragmaVAC) for Acute and Chronic Wounds: A Prospective, Randomized, Controlled Trial - Springer.com
Abstract by Mahmoud Hariri, Bakry Maaz, Measser Natfagi, Jude Alawa, Ahmad Sattouf, Hussam Alden Dubies, Jehad Alahmad, Muhammet Fuat Seyitisa, Amandine Godier-Furnemont, Abedalkarem Ghali, Ahmad Ghandour, Zohair Abdullah, Munther Alsaleh, Ibrahim Almousa, Waiel Habib and Hisham Alshaer (Canada, Turkey, Syira, USA - World Journal of Surgery).