Innate Immune System Activation, Inflammation and Corneal Wound Healing - Mdpi.com
Article by Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky and Wendy B. Bollag (Augusta, USA - IJMS).
This review demonstrates the need for acute inflammation to prevent pathogenic infiltration, while supporting the idea that a reduction in chronic and/or excessive inflammation will allow for improved wound healing.
Role of Senescent Cells in Cutaneous Wound Healing - Mdpi.com
Article by Allison M. Andrade, Mingda Sun, Nathan S. Gasek, Geneva R. Hargis, Roshanak Sharafieh and Ming Xu (Farmington, USA - Biology).
The authors review the rapidly growing field of cellular senescence and its role in wound healing biology.
Meeting the Challenges in Pediatric Wound Care: Our 15-Year Experience with Dialkylcarbamoyl Chloride-Coated Dressing Technology in Acute and Chronic Wounds - Dovepress.com
Article by Guido Ciprandi, Serena Crucianelli, Francesca Grussu, Giorgio Spuntarelli, Simone Faustino Maria Marino, Urbano Urbani, Paola Bernaschi, Annamaria Sisto, Maria Ida Rizzo and Mario Zama (Rome, Italy - Chronic Wound Care Management and Research).
The authors found that DACC technology dressings are of benefit in the treatment of pediatric wounds and offer a significant resource for the treatment of pediatric wounds.
Advances of hydrogel combined with stem cells in promoting chronic wound healing - Frontiersin.org
Article by Qirong Li, Dongxu Wang, Ziping Jiang, Rong Li, Tianyi Xue, Chao Lin, Yongzhi Deng, Ye Jin and Baozhen Sun (Changchun, China - Front. Chem.).
The combination of stem cells and stem cell derivatives with hydrogel is an attractive research topic in hydrogel preparation that offers great potential in chronic wound treatment. This review illustrates the development and application of advanced stem cell therapy-based hydrogels in chronic wound healing, especially in diabetic wounds and burns.
Microparticles Decorated with Cell-Instructive Surface Chemistries Actively Promote Wound Healing - Wiley.com
Abstract by Arsalan Latif, Leanne E Fisher, Adam A Dundas, Valentina Cuzzucoli Crucitti, Zeynep Imir, Karen Lawler, Francesco Pappalard, Benjamin W Muir, Ricky Wildman, Derek J. Irvine, Morgan R Alexander and Amir M Ghaemmaghami (Advanced Materials).
Impact of biofilm on Venous leg ulcers - Hospitalnews.com
Article by Joseph Stoffel.
The healing trajectory of many chronic wounds, such as Venous leg ulcers (VLUs), can be affected by the presence of biofilm. The author's insights on the complexity of wound biofilm communities and antimicrobial effectiveness.
Combined negative pressure wound therapy with irrigation and dwell time and artificial dermis prevents infection and promotes granulation formation in a ruptured giant omphalocele: a case report - Biomedcentral.com
Article by Yoichi Nakagawa, Hiroo Uchida, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Satoshi Makita, Hizuru Amano, Masamune Okamoto, Aitaro Takimoto, Seiya Ogata, Shunya Takada, Daiki Kato and Yousuke Gohda (Nagoya, Japan - BMC Pediatrics).
Studies have not been conducted regarding NPWTi-d for ruptured giant omphaloceles; hence, authors present their treatment experience with NPWTi-d for a giant omphalocele.
Efficacy and Safety of Topical Application of Olive Oil for Preventing Pressure Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PubMed
Abstract by Akram Hernández-Vásquez, Fabriccio J Visconti-Lopez, Cielo Cabanillas-Ramirez, Deysi Díaz-Seijas, Jessica Meléndez-Escalante, Daniel Comandé and Marilina Santero (Peru, Spain - Int J Environ Res Public Health).
A wound evaluation tool to prevent pressure ulcers - PubMed
Abstract by Mingjian Zhao and Hongliang Zhao (China - Front Surg.)
Risk Factors Associated With Pressure Injuries in Surgical Patients: A Retrospective Case-Control Study - PubMed
Abstract by Jung Yoon Kim and Hyun Hee Lee (Seongnam-si, Korea - J Wound Ostomy Continence Nurs.).
Experimental "smart" bandage speeds healing by zapping chronic wounds - Nature.com
Article by Ben Coxworth.
Chronic wounds such as diabetic skin ulcers can be very slow to heal, potentially leading to amputations or sometimes even death. A new bandage could speed their healing by delivering electrical stimulation, but only as needed.
Macrophage polarity and wound age determination - Newatlas.com
Article by Yumi Kuninaka, Yuko Ishida, Akiko Ishigami, Mizuho Nosaka, Jumpei Matsuki, Haruki Yasuda, Ayumi Kofuna, Akihiko Kimura, Fukumi Furukawa and Toshikazu Kondo (Kimiidera, Japan - Scientific Reports).
The authors' study showed that M1 and M2 macrophages in human skin wound might be a promising marker for wound age determination.
Surgical Site Infection in Cardiac Surgery - Mdpi.com
Article by Agnieszka Zukowska and Maciej Zukowski (Poland - JCM).
Due to their aggressive character, cardiac surgical procedures carry a particular high risk of postoperative infection, with infection incidence rates ranging from a reported 3.5% and 26.8% in cardiac surgery patients.
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing - Nature.com
Article by Yuanwen Jiang, Artem A. Trotsyuk, Simiao Niu, Dominic Henn, Kellen Chen, Chien-Chung Shih, Madelyn R. Larson, Alana M. Mermin-Bunnell, Smiti Mittal, Jian-Cheng Lai, Aref Saberi, Ethan Beard, Serena Jing, Donglai Zhong, Sydney R. Steele, Kefan Sun, Tanish Jain, Eric Zhao et al. (USA, China - Nature Biotechnology).
In mice, authors demonstrate that their wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment.
Novel modalities of delivering herbal medicines for wound healing: A review - Wiley.com
Abstract by Sakshi Soni, Shraddha Namdeo, Poornima Agrawal, Tanweer Haider and Vandana Soni (Dermatological Reviews).
Efficacy of Prophylactic Negative-Pressure Wound Therapy with Delayed Primary Closure for Contaminated Abdominal Wounds - PubMed
Abstract by Yo Sato, Eiji Sunami, Kenichiro Hirano, Motoko Takahashi and Shin-Ichi Kosugi (Niigata, Japan - Surg Res Pract.).
Nursing Assessment of Pressure Injury Risk with the Braden Scale Validated against Sensor-Based Measurement of Movement - PubMed
Abstract by Susan M Kennerly, Phoebe D Sharkey, Susan D Horn, Jenny Alderden and Tracey L Yap (USA - Healthcare (Basel)).
The LC-MS/MS Identification and Analgesic and Wound Healing Activities of Lavandula officinalis Chaix: In Vivo and In Silico Approaches - Mdpi.com
Article by Meryem Slighoua, Mohamed Chebaibi, Ismail Mahdi, Fatima Ez-zahra Amrati, Raffaele Conte, Mary Anne W. Cordero, Amal Alotaibi, Hamza Saghrouchni, Abdelkrim Agour, Touria Zair, Amina Bari and Dalila Bousta (Morocco, Italy, Saudi Arabia, Turkey - Plants).
This study sheds light on the potential of L. officinalis Chaix as a source of natural products for pharmaceutical applications for analgesic purposes as well as their utility in promoting burn-healing activity.
Wound Healing Potential and In Silico Appraisal of Convolvulus arvensis L. Methanolic Extract - Hindawi.com
Article by Uzma Saleem, Sana Khalid, Shingraf Zaib, Fareeha Anwar, Muhammad Furqan Akhtar, Liaqat Hussain, Ammara Saleem and Bashir Ahmad (Pakistan - BioMed Research International).
The study corroborates promising potential of C. arvensis on the healing of wounds, which possibly will be attributed to its antioxidant activity, fatty acids, quercetin, and gallic and caffeic acids, and binding potential of its phytoconstituents (phenolic acids) with wound healing targets.
Use of propolis for skin wound healing: systematic review and meta-analysis - PubMed
Abstract by Julia Carnelós Machado Velho, Thais Amaral França, Maria José Malagutti-Ferreira, Edilson Rodrigues Albuquerque, Francislaine Aparecida Dos Reis Lívero, Murilo Racy Soares, Ademilson Espencer Egea Soares and João Tadeu Ribeiro-Paes (Brazil - Arch Dermatol Res.).
Negative Pressure Wound Therapy for Complex Surgical Wounds in 59 Patients Across Secondary and Tertiary Care Centers in Turkey - Hmpgloballearningnetwork.com
Article by Ramazan Kahveci and Turkish Wound Working Group (Turkey).
The authors' findings indicate an association of negative pressure therapy with favorable wound healing outcome in complex wounds. Negative pressure therapy seems to be a useful treatment option to bridge wound care between initial debridement and final reconstruction.
A Prospective Study of Pressure Injury Healing Rate and Time and Influencing Factors in an Acute Care Setting - PubMed
Abstract by YoungMin Seo, HyunSoo Oh, YoungSun Na, MiJin Kim and WhaSook Seo (South Korea - Adv Skin Wound Care).
Characteristics of Venous Leg Ulcer Patients at a Tertiary Wound Care Center - PubMed
Abstract by Alyssa Klein, William Ennis and Eri Fukaya (USA - J Vasc Surg Venous Lymphat Disord.).
Comparing the application of various engineered xenografts for skin defects: A systematic review - PubMed
Abstract by Antoine Salloum, Nagham Bazzi, Stephen Squires, Thomas Chu, Paul Benedetto and Anthony Benedetto (USA, Lebanon - J Cosmet Dermatol.).
Wound Healing and Anti-Inflammatory Effects of a Newly Developed Ointment Containing Jujube Leaves Extract - Mdpi.com
Abstact by Marilena-Viorica Hovaneț, Emma Adriana Ozon, Elena Moroșan, Oana Cristina Șeremet, Eliza Oprea, Elisabeta-Irina Geană, Adriana Iuliana Anghel, Carmellina Bădiceanu, Ligia Elena Duțu, Cristina Silvia Stoicescu, Eugenia Nagoda and Robert Ancuceanu (Bucharest, Romania - Life).
Turning and Positioning for Pressure Injury Prevention - Woundsource.com
Pressure injuries are injuries to the skin and deeper tissues that occur due to direct pressure, shear, or friction forces. It is estimated that in the United States, 2.5 million pressure injuries occur yearly in acute care facilities alone.
Wound Exudate: What Does This Color Mean for My Patient? - Woundsource.com
Article by Holly Hovan.
In acute wounds, drainage typically decreases over several days while the wound heals, whereas in chronic wounds, a large amount of drainage is suggestive of prolonged inflammation with failure to move into the proliferative phase of wound healing.
Managing Wound Drainage - Woundsource.com
In normal wound healing, exudate plays an important role in allowing the migration of cells across the wound bed, facilitating the distribution of growth and immune factors vital to healing. Managing wound drainage involves making sure that exudate production is not too much or too little, and making sure the exudate does not have pus which would indicate an infection.
New Wound Management of Driveline Infections with Cold Atmospheric Plasma - Mdpi.com
Article by Jamila Kremer, Étienne Fasolt Richard Corvin Meinert, Mina Farag, Florian Mueller, Jasmin Penelope Soethoff, Matthias Karck, Bastian Schmack, Anna Lassia Meyer and Gregor Warnecke (Germany - JCDD).
Cold atmospheric plasma treatment is a potent, safe, and painless adjuvant technique for treating driveline infection without the need for repeating surgical interventions.
Schinus terebinthifolius Leaf Lectin (SteLL) Reduces the Bacterial and Inflammatory Burden of Wounds Infected by Staphylococcus aureus Promoting Skin Repair - Mdpi.com
Article by Marcio Anderson Sousa Nunes, Lucas dos Santos Silva, Deivid Martins Santos, Brenda da Silva Cutrim, Silvamara Leite Vieira, Izadora Souza Soeiro Silva, Simeone Júlio dos Santos Castelo Branco, Mayara de Santana do Nascimento, André Alvares Marques Vale et. al. (Brazil - Pharmaceuticals).
The authors' results corroborate the reported anti-infective properties of SteLL, making this lectin a lead candidate for developing alternative agents for the treatment of S. aureus-infected skin lesions.
The effectiveness of fractional carbondioxyde laser and microneedle radiofrequency on acne scars - Tandfonline.com
Abstract by Filiz Canpolat, Erol Koc and Selda Pelin Kartal (Ankara, Turkey).
A Comprehensive Physiotherapy Rehabilitation for Lower Limb Amputation as a Consequence of Cannabis and Alcohol Dependency: A Case Report - Cureus.com
Article by Sidra Ahmad Siraj, Chaitanya A. Kulkarni and Shubhangi Patil (Wardha, India).
The authors present a rare case of above-knee amputation secondary to complications of alcohol abuse where an extensive post-op care and elaborate physiotherapy program resulted in a successful recovery.
Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing - Mdpi.com
Article by Shahid Ud Din Wani, Mohammed Iqbal Zargar, Mubashir Hussain Masoodi, Sultan Alshehri, Prawez Alam, Mohammed M. Ghoneim, Areej Alshlowi, H. G. Shivakumar, Mohammad Ali and Faiyaz Shakeel (India, Saudi Arabia - IJMS).
Due to their tunable properties, silk fibroin-based drug delivery systems open up new possibilities for drug delivery, gene therapy, and wound healing.
Potential of Curcumin nanoemulsion as antimicrobial and wound healing agent in burn wound infection - PubMed
Abstract by Meera Kumari and Dhiraj Kumar Nanda (Bhubaneswar, India - Burns).
Simple Diverting Colostomy for Sacral Pressure Ulcers: Not So Simple After All - PubMed
Abstract by Gustavo A Rubio, Benjamin D Shogan, Konstantin Umanskiy, Roger D Hurst, Neil Hyman and Kinga Skowron Olortegui (Chicago, USA - J Gastrointest Surg.).
Cellular and Molecular Events of Wound Healing and the Potential of Silver Based Nanoformulations as Wound Healing Agents - Mdpi.com
Article by Caroline Tyavambiza, Mervin Meyer and Samantha Meyer (Belville, South Africa - Bioengineering).
This review describes the role of various cell types and molecules in the wound healing process. It will also review how silver containing wound healing agents including AgNPs affect these processes to promote wound healing.
Can Artificial Intelligence Predict Chronic Wound Healing? - Emjreviews.com
A thermal-imaging tool that was designed to screen for chronic wounds could allow nurses to identify hard-to-heal sores at first assessment in the patient’s home. These new results build on earlier research, which enabled nurses to identify chronic leg sores 2 weeks after assessment. New data shows that this can be done a week earlier.
Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells - PubMed
Abstract by Mahmoud G El Baassiri, Laura Dosh, Hanine Haidar, Alice Gerges, Silma Baassiri, Angelo Leone, Francesca Rappa and Abdo Jurjus (Lebanon, Italy - Burns).
The effects of psychological interventions on wound healing: A systematic review of randomized trials - Oa.mg
Abstract by Hayley Robinson, Sam Norton, Paul Jarrett and Elizabeth Broadbent (British Journal Of Health Psychology).
The diagnostic test accuracy of telemedicine for detection of surgical site infection: A systematic review protocol - Plos.org
Article by Ross Lathan, Misha Sidapra, Marina Yiasemidou, Judith Long, Joshua Totty, George Smith and Ian Chetter (Plos One).
This review systematically determines whether telemedicine is accurate for surgical site infection diagnosis, which methods are well established and if further research is indicated.
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Wound Healing - Mdpi.com
Article by Arulkumar Nallakumarasamy, Madhan Jeyaraman, Nicola Maffulli, Naveen Jeyaraman, Veerasivabalan Suresh, Srinath Ravichandran, Manu Gupta, Anish G. Potty, Saadiq F. El-Amin III, Manish Khanna and Ashim Gupta (India, Italy, UK - Life).
This article gives an outline of the biogenesis and mechanism of extracellular vesicles (EVs), particularly exosomes, in the process of tissue regeneration and discusses the use of preconditioned exosomes, platelet-rich plasma-derived exosomes, and engineered exosomes in three-dimensional bioscaffolds such as hydrogels (collagen and chitosan) to prolong the contact time of exosomes at the recipient site within the target tissue.
Robert Kirsner MD, PhD: Gaps in Knowledge on Wound Care in Dermatology Field - Hcplive.com
An SDPA 2022 interview with Dr. Robert Kirsner regarding his presentation regarding the topic of wound healing and related changes in the field.
Characteristic analysis of skin keratinocytes in patients with type 2 diabetes based on the single-cell levels - Lww.com
Article by Liao B, Ouyang Q, Song H, Wang Z, Ou J, Huang J and Liu L (Guangzhou, China - Chinese Medical Journal).
This study revealed the characteristics of keratinocytes at the single-cell level and screened a group of differentially expressed genes related to T2DM-associated keratinocytes, oxidative phosphorylation, cytokine receptor interactions, prion diseases, and other signaling pathways.
Hyaluronic Acid-Based Antibacterial Hydrogels for Use as Wound Dressings - PubMed
Abstract by Anna L Watson, Karoline E Eckhart, Michelle E Wolf and Stefanie A Sydlik (Pittsburgh, USA - ACS Appl Bio Mater.).
Impact of Antimicrobial-Resistant Bacterial and Polymicrobial Infection on Wound Healing After Minor Forefoot Amputation in Chronic Limb-Threatening Ischemia With Infection - PubMed
Abstract by Taku Kato, Takashi Yanagiuchi, Keita Hirano, Haruki Imura, Kunihiko Matsubara, Katsuyuki Hanabusa, Yutaro Ota, Shinya Yamazaki, Shunpei Ushimaru and Hirokazu Yokoi (Kyoto, Japan - J Endovasc Ther.).
Critical Care Nurses’ Knowledge, Attitudes, and Practices Regarding Pressure Injury Treatment: A Nationwide Cross-Sectional Survey - Dovepress.com
Article by Jiamin Li, Chen Zhu, Ying Liu, Baoyun Song, Jingfen Jin, Yilan Liu, Xianxiu Wen, Shouzhen Cheng and Xinjuan Wu (China - Risk Management and Healthcare Policy).
Critical care nurses exhibited a generally low level of knowledge and moderate attitudes regarding pressure injury treatment. Practices of pressure injury treatment were generally acceptable.
Pressure Injury Risk Assessment - Woundsource.com
A pressure injury (PI) is defined as a localized injury to the skin and/or underlying tissues caused by pressure either alone or in combination with shear.
Hospitalized patients worldwide frequently present with PIs, and these injuries can lead to prolonged hospital stays, increased medical expenses, and decreased quality of life. Often, the injuries can be preventable, and the use of a structured, validated risk assessment tool is an important initial step in PI prevention.
Peripheral Edema: Evaluation and Management in Primary Care - PubMed
Abstract by Hiten Patel, Christopher Skok and Anthony DeMarco (Columbus, USA - Am Fam Physician).
Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing - Mdpi.com
Article by Yucai Wang, Guangfu Wang and Hao Liu (China - Biomolecules).
The dynamic expression of Tenascin-C has a significant impact on angiogenesis and healing wounds and counters many negative aspects of poorly healing wounds, such as excessive inflammation, ischemia, scarring, and wound infection.
A time-dependent survival analysis for early prognosis of chronic wounds by monitoring wound alkalinity - Wiley.com
Article by Le Quynh Hoang, Suvra Pal, Zhaoli Liu, Jon Senkowsky and Liping Tang (International Wound Journal).
Frequent wound alkalinity assessments may serve as a novel way to prognosticate wound healing outcomes.
Biological activities and wound healing potential of a water-soluble polysaccharide isolated from Glycyrrhiza glabra in Wistar rat - Scielo.br
Article by A. A. Hmood, A. Feki, M. Eleroui, I. Kammoun, R. Kallel, T. Boudawara et. al. (Sfax, Tunisia - Brazilian Journal of Biology).
The authors' findings proved that this polysaccharide isolated from Glycyrrhiza glabra could be considered as a natural bioactive polymer for therapeutic process in wound healing applications.
Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation - Nature.com
Article by Yuan Yang, Ruizeng Luo, Shengyu Chao, Jiangtao Xue, Dongjie Jiang, Yun Hao Feng, Xin Dong Guo, Dan Luo, Jiaping Zhang, Zhou Li and Zhong Lin Wang (China, USA - Nature Communications).
This work highlights the promise of self-powered electrical adjuvants in improving drug pharmacodynamics, creating combinatorial therapeutic strategies for traditional drugs.
The initiation of oxidative stress and therapeutic strategies in wound healing - Sciencedirect.com
Article by Gang Wang, Feifei Yang, Weiying Zhou, Nanyang Xiao, Mao Luo and ZonghaoTang (China, USA - Biomedicine & Pharmacotherapy).
The authors discussed the physiological rhythms of wound healing and the role of oxygen species in this progress, aim to explore the potential manipulation of oxidative stress as a promising therapeutic avenue.
Negative-pressure wound therapy as an adjunct to treating pyoderma gangrenosum - PubMed
Abstract by Orlagh Mulholland, David Middleton and Helen Hunter (Belfast, UK - J R Coll Physicians Edinb.).
Artificial Intelligence Methodologies Applied to Technologies for Screening, Diagnosis and Care of the Diabetic Foot: A Narrative Review - PubMed
Abstract by Gaetano Chemello, Benedetta Salvatori, Micaela Morettini and Andrea Tura (Italy - Biosensors (Basel)).
Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice - PubMed
Abstract by Piotr Sass, Paweł Sosnowski, Jolanta Kamińska, Milena Deptuła, Aneta Skoniecka, Jacek Zieliński, Sylwia Rodziewicz-Motowidło, Michał Pikuła and Paweł Sachadyn (Gdańsk, Poland - J Tissue Eng Regen Med.).
A wound alkalinity measurement to predict non-healing wound outcomes - Magonlinelibrary.com
Abstract by Jon Senkowsky, Shuxin Li, Ashwin Nair, Suvra Pal, Wenjing Hu and Liping Tang (Journal of Wound Care).
Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment - Science.org
Article by Rebecca A. Keogh, Amanda L. Haeberle, Christophe J. Langouët-Astrié, Jeffrey S. Kavanaugh, Eric P. Schmidt, Garrett D. Moore, Alexander R. Horswill and Kelly S. Doran (Aurora, USA - Science Advances).
This foundational study provides insight into the pathogenesis of GBS diabetic wound infections.
Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds - PubMed
Abstract by Karena Herron (USA - J Wound Care).
The antimicrobial, antibiofilm, and wound healing properties of ethyl acetate crude extract of an endophytic fungus Paecilomyces sp. (AUMC 15510) in earthworm model - Nature.com
Article by Shimaa H. Salem, Saad S. El-Maraghy, Ahmed Y. Abdel-Mallek, Mohamed A. A. Abdel-Rahman, Emad H. M. Hassanein, Osama A. Al-Bedak and Fatma El-Zahraa A. Abd El-Aziz (Egypt - Scientific Reports).
Paecilomyces sp. (AUMC 15510) could be a sustainable source of antimicrobial agents and a potential therapeutic target for wound management.
Combination therapy of hydrogel and stem cells for diabetic wound healing - Wjgnet.com
Article by Jia-Na Huang, Hao Cao, Kai-Ying Liang, Li-Ping Cui and Yan Li (China - World J Diabetes).
The authors' review summarizes the mechanisms and applications of stem cells and hydrogels in treating diabetic wounds (DWs); additionally, it focuses on the different applications of therapy combining hydrogel and stem cells for DW treatment.
Role of defensins in diabetic wound healing - Wjgnet.com
Article by Zhi-Xiang Tan, Rui Tao, Si-Cheng Li, Bing-Zheng Shen, Lan-Xia Meng and Zhan-Yong Zhu (Wuhan, China - World J Diabetes).
In this review, the authors' describe the complex function of human defensins in the development of diabetic wounds, and suggest potential thera-peutic benefits.
Preparation of Transdermal Patch Containing Selenium Nanoparticles Loaded with Doxycycline and Evaluation of Skin Wound Healing in a Rat Model - Mdpi.com
Article by Dhiya Altememy, Moosa Javdani, Pegah Khosravian, Anita Khosravi and Elham Moghtadaei Khorasgani (Iraq, Iran - Pharmaceuticals).
The authors' results showed that the simultaneous presence of selenium nanoparticles and doxycycline in the ChSeND group provided the best repair compared to the control, Ch and ChSeN groups.
Contactless screening tool could revolutionize chronic wound treatment - Sciencedaily.com
A thermal-imaging tool to screen for chronic wounds could enable nurses to identify these hard-to-heal sores during the first assessment at a person's home. Nearly half a million Australians live with chronic wounds, which greatly affect their quality of life and cost the nation's health system around $3 billion each year.
Relationship between healing status and microbial dissimilarity in wound and peri-wound skin in pressure injuries - PubMed
Abstract by Mao Kunimitsu, Gojiro Nakagami, Aya Kitamura, Takeo Minematsu, Sofoklis Koudounas, Kazuhiro Ogai, Junko Sugama, Chika Takada, SeonAe Yeo and Hiromi Sanada (Japan - J Tissue Viability).
How the Identification of Chronic Wound Infection Can Be Improved With Technology - Woundsource.com
Article by Liping Tang.
Infection is the single most likely cause of delayed healing in chronic wounds. In most cases, identification of chronic wound infection (eg, diabetic foot ulcers and venous leg ulcers) is not obvious since chronic wounds do not exhibit the same classic inflammatory signs of infection as those found in acute wounds.
Preventing Medical Device-Related Pressure Injuries - Woundsource.com
Medical device-related pressure injuries (MDRPIs) are defined as injuries associated with using devices applied for diagnostic or therapeutic purposes, where the injury tends to have the same configuration as the device.
Forget Dr. Google! Helping Patients Understand Wound Care Goals - Woundsource.com
About 89 percent of people who come to doctors’ offices have already Googled their symptoms, notes Scott Covington, MD, FACS, CWSP. He says most patients wanted to see how serious their health condition was before going to an actual doctor.
Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment - Mdpi.com
Article by Pivian Sim, Xanthe L. Strudwick, Yun Mei Song, Allison J. Cowin and Sanjay Garg (Adelaide, Australia - IJMS).
The authors' study shows the importance of maintaining an acidic wound microenvironment at pH 4, which could be a potential therapeutic strategy for wound management.
Investigating the effects of low intensity visible light on human keratinocytes using a customized LED exposure system - Nature.com
Article by Emily Sutterby, Chanly Chheang, Peter Thurgood, Khashayar Khoshmanesh, Sara Baratchi and Elena Pirogova (Australia - Scientific Reports).
The authors' results demonstrate increased proliferation and decreased scratch area for all exposure conditions, however only red light increased the mitochondrial activity. Oxidative stress levels did not increase for any of the exposures.
An Algorithm for Prevention of Unsightly Facial Scars Considering the Newest Research Insights - Lww.com
Article by Dominik L. Feinendegen, Alexandra Grubnik and Sandra Y. MLitt Feinendegen (Switzerland, Ukraine, South Africa, Germany - Plastic and Reconstructive Surgery - Global Open).
To prevent unsightly facial scars, a well-defined algorithm must be followed. In summary, three well-established, empirically proven measures are documented now by the equivalent physiological scientific proof: (1) the flat incision technique, (2) the wound closure with maximal tension reduction, and (3) the postoperative scar management with further tension reduction and more moisturizing of the scar.
Wound healing mechanism of antimicrobial peptide cathelicidin-DM - Frontiersin.org
Article by Guixi Wang, Zhizhi Chen, Pan Tian, Qinqin Han, Jinyang Zhang, A-Mei Zhang and Yuzhu Song (Kunming, China - Front. Bioeng. Biotechnol.).
The authors' data suggest that cathelicidin-DM (Duttaphrynus melanostictus) can be engaged in the healing of infected and non-infected wounds through multiple pathways, providing a new strategy for the treatment of infected chronic wounds.
Research status and hot topics of the effects of skin innervation on wound healing from 1959 to 2022: A bibliometric analysis - PubMed Central
Article by Ru Song, Zhenjie Wu, Jiaxu Ma, Siyuan Yin, Chunyan Liu, Rui Sun, Guoqi Cao, Yongpan Lu, Aoyu Chen, Guang Zhang, Jian Liu and Yibing Wang (Jinan, China - Front Surg.).
This bibliometric analysis will inform the overall trends in research related to the effect of skin innervation on wound healing, summarise relevant research hotspots, and guide future work.
Hot spring bathing accelerates wound healing and enhances heat retention effect in guinea pigs - PubMed
Abstract by Kengo Inaka and Tohru Kimura (Yamaguchi, Japan - J Vet Med Sci.).
Serpin-loaded extracellular vesicles promote tissue repair in a mouse model of impaired wound healing - Biomedcentral.com
Article by Dong Jun Park, Erika Duggan, Kayla Ho, Robert A. Dorschner, Marek Dobke, John P. Nolan and Brian P. Eliceiri (USA - Journal of Nanobiotechnology).
The authors established a novel therapeutic approach by engineering the payload of extracellular vesicles based on proteomic analysis.
Microneedling combined with botulinum toxin-A versus microneedling combined with platelet-rich plasma in treatment of atrophic acne scars: a comparative split face study - Springer.com
Article by Waleed Albalat, Soheir Ghonemy, Ayat Saleh and Mona Elradi (Zagazig, Egypt - Archives of Dermatological Research).
Both combinations present efficacious options for treating acne scars with comparable efficacy.
Use of Optical Coherence Tomography (OCT) in Assessment of Diabetic Skin Wound Characteristics and Blood Flow - PubMed
Abstract by Shyon Parsa, Christine Wamsley, Paul Kim, Jeffrey Kenkel and Yucel Akgul (Dallas, USA - J Foot Ankle Surg.).
Therapeutic applications of garlic and turmeric for the diabetic wound healing in mice - Oup.com
Abstract by Muhammad A Farooq, Shaukat Ali, Rida Sulayman, Ali Hassan, Hafiz M Tahir, Hafsa Shahzad, Umaima Fiaz, Tafail A Mughal, Irfana Liaqat, Samaira Mumtaz, Tooba Nauroze and Shumaila Mumtaz (Pakistan, Journal of Burn Care & Research).
Identification of Charcot Foot: A Case Report - PubMed
Abstract by Angela Phillips and Louise Rice (USA - Nephrol Nurs J.).
Chitosan-based films with cannabis oil as a base material for wound dressing application - Nature.com
Article by Dorota Chelminiak-Dudkiewicz, Aleksander Smolarkiewicz-Wyczachowski, Kinga Mylkie, Magdalena Wujak, Dariusz T. Mlynarczyk, Pawel Nowak, Szymon Bocian, Tomasz Goslinski and Marta Ziegler-Borowska (Poland - Scientific Reports).
Cell culture studies revealed that the obtained materials are biocompatible and, therefore, they might be potential candidates for application in wound dressing materials.
Mussel-inspired hydrogel with injectable self-healing and antibacterial properties promotes wound healing in burn wound infection - Nature.com
Article by Ao Sun, Danrong Hu, Xinye He, Xiao Ji, Tao Li, Xiawei Wei and Zhiyong Qian (Chengdu, China - NPG Asia Materials).
The authors' results showed that the hydrogel exhibits good antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and has antioxidant effects in vitro. Moreover, the hydrogel also exhibits good adhesion. In a burn wound infection model, the hydrogel promoted wound healing and reduced the production of inflammation.
Comparison of Wound Healing Effect of Skin Micrograft Impregnated into Two Kinds of Artificial Dermis in a Murine Wound Model - Lww.com
Article by Li, Yuanjiaozi, Sakamoto, Michiharu, Sawaragi, Eiichi, Nakano, Takashi, Katayama, Yasuhiro, Yamanaka, Hiroki, Tsuge, Itaru and Morimoto, Naoki (Kyoto, Japan - Plastic and Recostructive Surgery - Global Open).
Skin micrograft was successfully impregnated into Pelnac Gplus by simple administration but not into Integra. Administration of skin MG into the Pelnac Gplus promoted granulation formation and angiogenesis. Pelnac Gplus was more suitable than Integra in the combination therapy.
New Study Champions Honey to Help Wounds Heal - Dermatologytimes.com
Article by Keith Lora.
The published study is a review of more than 250 articles over 85 years that covered honey’s antimicrobial and wound healing properties, with a special focus on potential tissue engineering applications.
Overexpression of VEGF in dermal fibroblast cells accelerates the angiogenesis and wound healing function: in vitro and in vivo studies - Nature.com
Article by Forough Shams, Hamideh Moravvej, Simzar Hosseinzadeh, Ebrahim Mostafavi, Hadi Bayat, Bahram Kazemi, Mojgan Bandehpour, Elnaz Rostami, Azam Rahimpour and Hamidreza Moosavian (Iran, USA - Scientific Reports).
The authors' findings indicate that overexpression of VEGF165 in fibroblast cells results in enhanced angiogenesis and formation of granulated tissue in the early stage of the healing process, which can show its therapeutic potential in patients with impaired wound healing and also provide functional support for gene therapy.
Researchers studying new way to heal diabetic wounds by activating 'hidden' mechanism in the body - Sciencedaily.com
Researchers at Indiana University School of Medicine are looking for ways to heal wounds by using a healing protein that is active in fetuses, but largely inactive in adults and absent in diabetic adults.
Early outcomes of complete excision followed by immediate postoperative single fractional 10 Gy for anterior chest keloids: A preliminary results - Wiley.com
Article by Boram Ha, Sung Jae Kim, Yu Jun Lee, Seongcheol Im and Tae Hwan Park (International Wound Journal).
The authors' preliminary results show positive outcomes of complete excision followed by postoperative single fractional 10 Gy radiotherapy for recurrent anterior chest keloids on the same day.
Wound Healing versus Metastasis: Role of Oxidative Stress - Mdpi.com
Article by Tatiana Lopez, Maeva Wendremaire, Jimmy Lagarde, Oriane Duquet, Line Alibert, Brice Paquette, Carmen Garrido and Frédéric Lirussi (France - Biomedicines).
This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages.
Macrophages undergo a behavioural switch during wound healing in zebrafish - Sciencedirect.com
Article by Tamara Sipka, Seol Ah Park, Resul Ozbilgic, Laurence Balas, Thierry Durand, Karol Mikula, Georges Lutfalla and Mai Nguyen-Chia (France, Slovakia - Free Radical Biology and Medicine).
The authors' findings suggest that individual macrophages at the wound switch their phenotype leading to important changes in behaviour and shape to adapt to changing environment, and highlight the crucial role of lipid metabolism in the control of macrophage behaviour plasticity during inflammation in vivo.
Increased Expression of miR-155 in Peripheral Blood and Wound Margin Tissue of Type 2 Diabetes Mellitus Patients Associated with Diabetic Foot Ulcer - Dovepress.com
Article by Murong Xu, Yutong Li, Ying Tang, Xiaotong Zhao, Dandan Xie and Mingwei Chen (Hefei, China - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy).
The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU. MiR-155 is a potentially valuable biomarker for diagnosis and prognosis of DFU.
Nanofiber Aerogels with Precision Macrochannels and LL-37-Mimic Peptides Synergistically Promote Diabetic Wound Healing - Wiley.com
Article by Johnson V. John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini and Jingwei Xie (Advanced Functional Materials).
The approach developed in this study could be promising for the treatment of diabetic wounds and other chronic wounds.
Bioactive saponins of Primula vulgaris Huds. promote wound healing through inhibition of collagenase and elastase enzymes: In vivo, in vitro and in silico evaluations - PubMed
Abstract by Cigdem Kahraman, Suat Sari, Esra Küpeli Akkol and I Irem Tatli Cankaya (Ankara, Turkey - Chem Biodivers.).
Skin graft fixation with negative pressure wound therapy with instillation and dwelling (NPWTi-d) for contaminated complex wounds of the extremities - PubMed
Abstract by Kanako Danno, Mitsunaga Narushima, Chihena H Banda, Yoshimoto Okada, Kohei Mitsui, Yuta Shimizu, Makoto Shiraishi, Kyoko Sugioka, Naho Yokota, Shinya Yamamoto and Ryohei Ishiura (Japan - JPRAS Open).
Surgical Wounds: How to Prevent Wound Dehiscence - Woundsource.com
Article by Holly Hovan.
Surgical wounds are defined as incisions that are made during a surgical procedure. Wound dehiscence is when part or all of the wound comes apart and typically occurs 5-8 days postoperatively.
Preventing Post-Operative Complications - Woundsource.com
It is estimated that between 3% and 27% of surgical patients have unforeseen complications related to their surgical event. Although not all complications can be prevented, some can be avoided through vigilant care immediately after surgery. Many complications can be avoided through basic care strategies.
The art and science of selecting appropriate dressings for acute open wounds in general practice - PubMed
Abstract by Sankar N Sinha, Belinda Free and Oliver Ladlow (Australia - Aust J Gen Pract.).
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