Jellyfish Polysaccharides for Wound Healing Applications - Mdpi.com
Article by Chiara Migone, Noemi Scacciati, Brunella Grassiri, Marinella De Leo, Alessandra Braca, Dario Puppi, Ylenia Zambito and Anna Maria Piras (Pisa, Italy - IJMS).
The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
How to Tell if a Wound is Healing or Infected - Buzzrx.com
Article by Juhi Modi. Scrape on knees, minor cuts, animal bites, surgical incisions - wounds come in many shapes and sizes. Essentially, wounds are anything that break the skin. As soon as the skin is wounded, the body springs into action and starts the healing process. But how do you tell if a wound is healing properly?
A scientometrics analysis and visualisation of diabetic foot research from 1955 to 2022 - PubMed
Abstract by Jin-Ming Shen, Jie Chen, Lei Feng and Chun Feng (Hangzhou, China - Int. Wound J.)
An enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocomposites - Nature.com
Article by Manjubaashini Nandhakumar, Daniel Thangadurai Thangaian, Senthilarasu Sundaram, Anurag Roy and Balakumar Subramanian (India, UK - Scientific Reports).
The authors' results showed decreased inflammation sites in the wound area, assessed by the (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) assay with ~ 80% radical scavenging activity, confirming their anti-inflammatory and improved wound healing properties.
Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing - Nature.com
Article by Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, Xishen Xu, Zhaokui Jin and Qianjun He (China - Nature Communications).
The proposed visible light-photocatalytic strategy provides a solution for facile, safe and efficient treatment of DFU.
A simplified method for monitoring cytokines in wound fluid - Wiley.com
Abstract by Ewa Anna Burian, Christian Enevold, Tonny Karlsmark and Magnus S. Ågren (Wound Repair and Regeneration).
Ionic complexation improves wound healing in deep second-degree burns and reduces in-vitro ciprofloxacin cytotoxicity in fibroblasts - Nature.com
Article by María Florencia Sanchez, María Laura Guzman, Jesica Flores-Martín, Mariano Cruz Del Puerto, Carlos Laino, Elio Andrés Soria, Ana Carolina Donadio, Susana Genti-Raimondi and María Eugenia Olivera (Argentina - Scientific Reports).
This work highlights the great potential of this smart system as an attractive dressing for burns, which surpasses currently available treatments.
Evaluation of wound healing effects of micronized acellular dermal matrix in combination with negative pressure wound therapy: In vivo study - Wiley.com
Article by Jeongmok Cho, Hyun Hwang, Shin Young Song, Hyunsuk Peter Suh and Joon Pio Hong (International Wound Journal).
The authors' results show that the combination of micronized acellular dermal matrix and NPWT has a synergistic wound healing effect.
Nurses' knowledge on pressure ulcer prevention: An updated systematic review and meta-analysis based on the Pressure Ulcer Knowledge Assessment Tool - PubMed
Abstract by Jing Wu, Bangjun Wang, Liping Zhu and Xiaoli Jia (China - Front Public Health).
Reducing Surgical Site Infection by Prophylactic Negative Pressure Wound Therapy in a Cohort of General Surgery Patients - PubMed
Abstract by Vladimir Piroski, Elisa Müller, Eva Herrmann, Ernst Hanisch and Alexander Buia (Germany - Visc. Med.).
Pilot study: utility of long-wave infrared thermography as a correlate to transcutaneous oximetry for candidates of hyperbaric oxygen therapyThe impact of delayed wound healing on patient-reported outcomes after breast cancer surgery - PubMed
Abstract by Marvin Heyboer 3rd, Andrew G Kozminski, Lauren D Pacelli and Susan M Wojcik (USA - Wound Repair Regen.).
Beating the Odds in Wound Care: Is it a Terminal Ulcer? - Woundsource.com
Article by Jeffrey M. Levine.
Words matter - particularly when coming from authority figures such as doctors and nurses. Terminal ulcer terminology has been in the wound care literature for over 3 decades, but the designation depends on future events that nobody can accurately predict.
What Is a Kennedy Terminal Ulcer? - Woundsource.com
Article by Cathy Wogamon-Harmon.
Many questions arise when wound care providers mention Kennedy terminal ulcers (KTUs). Since these wounds are not frequently seen and develop rapidly with observation ending abruptly with the death of the patient, wound care providers may have never observed a KTU, even in a long career in wound care.
Animal Models for the Study of Acute Cutaneous Wound Healing - Wiley.com
Abstract by Shayan Saeed and Manuela Martins-Green (Riverside, Canada - Wound Repair and Regeneration).
The Stimulation of Macrophages by Systematical Administration of GM-CSF Can Accelerate Adult Wound Healing Process - Mdpi.com
Article by Jing Zhang, Liyuan Jia, Hanxue Zheng, Juantao Feng, Sili Wei, Juan Li, Jihong Cui and Fulin Chen (Xi’an, China - IJMS).
The current study demonstrated that macrophages are critical for skin regeneration and that GM-CSF exhibited therapeutic potential for wound healing.
The impact of delayed wound healing on patient-reported outcomes after breast cancer surgery - PubMed
Abstract by Lea Zehnpfennig, Mathilde Ritter, Giacomo Montagna, Tristan M Handschin, Barbara M Ling, Ida Oberhauser, Jérémy Lévy, Kristin Marit Schaefer, Nadia Maggi, Savas D Soysal, Liliana Castrezana López, Madleina M Müller, Fabienne D Schwab, Martin Haug, Walter P Weber, Christian Kurzeder and Elisabeth A Kappos (Switzerland, USA - J Plast Reconstr Aesthet Surg.).
Evaluation of pressure ulcer risk and development in operating rooms - PubMed
Abstract by Elif Karahan, Aysun Uslu Ayri and Sevim Çelik (J Tissue Viability).
Actin cable formation and epidermis–dermis positional relationship during complete skin regeneration - Nature.com
Article by Kento Takaya, Keisuke Okabe, Ayaka Ishigami, Yuka Imbe, Hideko Kanazawa, Shigeki Sakai, Noriko Aramaki-Hattori and Kazuo Kishi (Tokyo, Japan - Scientific Reports).
The authors found that the three-dimensional structure of the skin was completely regenerated in full-thickness skin incisions made before embryonic day (E) 13.
Clinical application of traditional Chinese medicine powder in the treatment of acute and chronic wounds - Wiley.com
Article by Fu-Lei Li, Gao-Chao Wang and Bu-Qiang Wu (China - International Wound Journal).
The TCM powder absorbed a large amount of necrotic tissue and exudate from the wound surface, cleared heat and toxins, and activated blood circulation. It also resolved blood stasis, eliminated pus, and allowed for new skin growth, as well as regenerating muscle.
Topical esmolol hydrochloride may aid healing of diabetic foot ulcers - Medwirenews.com
Article by Alba Ruzafa.
The use of esmolol hydrochloride in adults with diabetic foot ulcer improves wound healing and may constitute a novel treatment option, suggests research reported at the 58th EASD Annual Meeting in Stockholm, Sweden.
Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement - Mdpi.com
Article by Hao Ma, Yuan Peng, Shunuo Zhang, Yixin Zhang and Peiru Min (Shanghai, China - Gels).
This review aims to summarize the application of photo-crosslinking hydrogels in improving the quality of wound healing, mainly including the material design, application mechanism, and effect of photo-crosslinking hydrogels applied in wound healing, followed by the applicable animal models for experimental research.
Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction - Frontiersin.org
Article by Shuting Yang, You Li, Chengcheng Liu, Yafei Wu, Zixin Wan and Daonan Shen (Chengdu, China - Front. Endocrinol.).
The authors' work showed topical administration of plasma-rich growth factor, advanced platelet-rich fibrin, leukocyte- and platelet-rich fibrin and hyaluronic acid as well as maxillary immediate complete denture is regarded as a promising approach for clinical management of diabetic patients requiring extractions.
Debridement of Diabetic Foot Ulcers - PubMed
Abstract by David Dayya, Owen J O'Neill, Tania B Huedo-Medina, Nusrat Habib, Joanna Moore and Kartik Iyer (USA - Adv Wound Care (New Rochelle)).
Macrophage-Mediated Inflammation in Skin Wound Healing - Mdpi.com
Article by Alireza Hassanshahi, Mohammad Moradzad, Saman Ghalamkari, Moosa Fadaei, Allison J. Cowin and Mohammadhossein Hassanshahi (Australia, Iran - Cells).
In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. The authors also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing.
Risk profiling in the prevention and treatment of chronic wounds using artificial intelligence - Wiley.com
Article by Karen Cross and Keith Harding (International Wound Journal).
With an understanding and continued modification of the algorithms behind AI, clinicians can and will adopt this type of approach in the prevention and management of chronic wounds. AI is a transformative technology and has immense potential in wound care.
The Healing Power of Hyperbaric Oxygen Therapy - Uhhospitals.org
Hyperbaric oxygen therapy (HBOT) is a noninvasive, painless treatment that supports the body’s natural healing capabilities. It does this by delivering high concentrations of oxygen to the bloodstream to help heal persistent wounds, injuries and infections.
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair - Nature.com
Article by Jadie Y. Moon, Frank M. Davis, Emily C. Barrett, Kevin D. Mangum, Hongping Deng, Xianying Xing, Rachel Wasikowski, Lam C. Tsoi, Sriganesh B. Sharma, Tyler M. Bauer, James Shadiow, Matthew A. Corriere, Andrea T. Obi, Steven L. Kunkel, Benjamin Levi, Bethany B. Moore, Johann E. Gudjonsson, Andrew M. Smith and Katherine A. Gallagher (USA - Cellular & Molecular Immunology).
The authors demonstrate that macrophage-specific, nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING. Taken together, this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.
Photobiomodulation at 830 nm Stimulates Migration, Survival and Proliferation of Fibroblast Cells - Dovepress.com
Article by Olajumoke Arinola Oyebode and Nicolette Nadene Houreld (Gauteng, South Africa - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy).
This study contributes to the growing body of knowledge on the molecular and cellular effect of PBM and showcases the suitability of PBM at 830 nm in managing diabetic wounds.
Antimicrobial cryogel dressings towards effective wound healing - PubMed
Abstract by Basak Akin and Mehmet Murat Ozmen (Istanbul, Turkey - Prog Biomater.).
Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions - PubMed
Abstract by Irena Pastar, Nathan C Balukoff, Jelena Marjanovic, Vivien Y Chen, Rivka C Stone and Marjana Tomic-Canic (Miami, USA - Cold Spring Harb Perspect Biol.).
Wound Healing and Assessment - Lww.com
Article by Jessica Simmons (Charlottesville, USA - Journal of the Dermatology Nurses’ Association).
A holistic approach to assessing the wound is required and will guide in the development of a plan of care.
Dual-Functional Nanofibrous Patches for Accelerating Wound Healing - Mdpi.com
Article by Dan Xia, Yuan Liu, Wuxiu Cao, Junwei Gao, Donghui Wang, Mengxia Lin, Chunyong Liang, Ning Li and Ruodan Xu (China - IJMS).
The coaxial mats showed superior biocompatibility toward human immortalized keratinocytes. This study indicates a coaxial nanofiber membrane combining anti-bacterial and anti-inflammation agents has great potential as a wound dressing for promoting wound repair.
Electrospinning of botanicals for skin wound healing - Frontiersin.org
Article by Shijie Guo, Pengyu Wang, Ping Song and Ning Li (Beijing, China - Front. Bioeng. Biotechnol.).
The authors propose that potential clinical applications of botanical electrospun membranes require not only the further expansion and understanding of botanicals, but also an establishment of standard criteria for the evaluation of wound healing and evolutions of technologies to support the large-scale manufacturing industry.
Modification of the immune response by bacteriophages alters methicillin-resistant Staphylococcus aureus infection - Nature.com
Article by Tomoya Suda, Tomoko Hanawa, Mayuko Tanaka, Yasunori Tanji, Kazuhiko Miyanaga, Sanae Hasegawa-Ishii, Ken Shirato, Takako Kizaki and Takeaki Matsuda (Japan - Scientific Reports).
The authors' results show that the immune modulation occurring as a response to the phage itself improves the clinical outcomes of phage therapy.
3D-Printed Gelatin-Alginate Hydrogel Dressings for Burn Wound Healing: A Comprehensive Study - Whioce.com
Article by Fateme Fayyazbakhsh, Michael J. Khayat and Ming C. Leu (USA, Canada - Int J Bioprint).
Results from this research showed that 3D-printed dressings with an adequate gelatin: alginate ratio enhanced wound healing activity for up to 7 days of moisture retention on deep partial-thickness burn wounds.
Fabrication, In Vitro, and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing - Mdpi.com
Article by Anis Rehman, Muhammad Iqbal, Barkat A. Khan, Muhammad Khalid Khan, Bader Huwaimel, Sameer Alshehri, Ali H. Alamri, Rami M. Alzhrani, Deena M. Bukhary, Awaji Y. Safhi and Khaled M. Hosny (Pakistan, Saudi Arabia - Pharmaceutics).
The authors' results suggest that the formulated optimized dosage showed optimum stability, and it can be considered an effective wound healing alternative.
Topical ointment made from tree sap found to be effective in treating skin wound infections - Medicalxpress.com
Article by Bob Yirka.
A team of researchers affiliated with multiple institutions in the U.K. and Australia has developed a nontraditional ointment to treat skin wound infections based on a molecule found in the sap of a Queensland blushwood tree. The study is published in the journal Science Translational Medicine.
The Evolution of Antisepsis: A Historical Review - Woundsource.com
Article by Christine Miller.
As the 20th century progressed, antibiotics took center stage in the therapeutic spectrum, but antiseptics still maintain an important position in infection management. Clinicians of the past overcame many challenges in the pursuit of healing.
Initiation of wound healing is regulated by the convergence of mechanical and epigenetic cues - Plos.org
Article by Tanay Bhatt, Rakesh Dey, Akshay Hegde, Alhad Ashok Ketkar, Ajai J. Pulianmackal, Ashim P. Deb, Shravanti Rampalli and Colin Jamora (Bangalore, India - Plos Biology).
The authors' findings illuminate the convergence of mechanical and epigenetic signaling modules that are important regulators of the transcriptome landscape required to initiate the tissue repair process in the differentiated layers of the epidermis.
The Clinical Value of Methicillin-Resistant Staphylococcus aureus Nasal Screening in the Management of Diabetic Foot Infections - PubMed
Abstract by Jeff Hosry, Taylor Wang, Marc Assaad, Ralph Kamel, Sylvester Homsy, Elsa Sleiman, Allison Glaser and Neville K Mobarakai (Staten Island, USA - Int J Low Extrem Wounds).
Photodynamic therapy for treating infected skin wounds: A systematic review and meta-analysis from randomized clinical trials - PubMed
Abstract by Analú Barros de Oliveira, Túlio Morandin Ferrisse, Carla Raquel Fontana, Fernanda Gonçalves Basso and Fernanda Lourenção Brighenti (São Paulo, Brazil - Photodiagnosis Photodyn Ther.).
Water for wound cleansing - Cochranelibrary.com
Article by Ritin Fernandez, Heidi L Green, Rhonda Griffiths, Ross A Atkinson and Laura J Ellwood.
Cleansing with tap water may make little or no difference to wound healing compared with no cleansing; there are no data relating to the impact on wound infection. The effects of cleansing with tap water, cooled boiled water or distilled water compared with cleansing with saline are uncertain, as is the effect of distilled water compared with cooled boiled water.
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds - Science.org
Article by Lydia C. Powell, Jason K. Cullen, Glen M. Boyle, Tom De Ridder at al. (Science Translational Medicine).
The authors' highlight a nonantibiotic approach involving contrasting, orthogonal mechanisms of action combining targeted biofilm disruption and innate immune induction in the treatment of chronic wounds.
Health economics of diabetic foot ulcer and recent trends to accelerate treatment/a> - Sciencedirect.com
Article by Abha Jodheea-Jutton, Sandip Hindocha and Archana Bhaw-Luximonb (Mauritus, UK - The Foot).
This review aims at discussing the geographical health economics, its impact on healing and factors influencing financial costs of DFU. The upcoming economic and clinical impacts due to disease outbreak such as the 2020 COVID-19 has also been discussed.
Healing Potential of Propolis in Skin Wounds Evidenced by Clinical Studies - Mdpi.com
Article by Cristiano da Rosa, Ian Lucas Bueno, Ana Clara Martins Quaresma and Giovanna Barbarini Longato (São Paulo, Brazil - Pharmaceuticals).
The potential of propolis as an alternative healing treatment for skin wounds such as diabetic, venous, and surgical wounds, as well as wounds caused by burns, etc., is mainly due to its evidenced properties such as antimicrobial, anti-inflammatory, analgesic, and angiogenesis promoter effects. However, there is a need to standardize the type of administration and the concentration of propolis for each type of wound.
A Preliminary Direct Comparison of the Inflammatory Reduction and Growth Factor Production Capabilities of Three Commercially Available Wound Products: Collagen Sheet, Manuka Honey Sheet, and a Novel Bioengineered Collagen Derivative + Manuka Honey + Hydroxyapatite Sheet - Mdpi.com
Article by Isaac Rodriguez, Tricia Conti and Nina Bionda (USA - IJMS).
There is a need for products that can reliably and comprehensively progress a wound through multiple stages. This comprehensive product approach would allow for flexibility during treatment by not having to predict which single product will progress the wound based on the likely stage the wound is in. Wounds are complex, and comprehensive products should exist to simplify their treatment.
Erythrophagocytes in hemolytic anemia, wound healing, and cancer - PubMed
Abstract by Rok Humar, Dominik J Schaer and Florence Vallelian (Zurich, Switzerland - Trends Mol Med.).
A Comparative Immunohistochemical Study of Wound Healing after Dental Diode Laser Treatment in the Rat Oral Mucosa - Mdpi.com
Article by Hye Rin Kim, Keunbada Son, Young-Tak Son, Yong-Gun Kim, Kyu-Bok Lee, Seung Cheol Lee, Jo-Young Suh and Jae Mok Lee (South Korea - Bioengineering).
Laser-induced wounds tended to heal slower than surgical wounds performed using a steel scalpel, but histological and immunohistochemical results showed no significant difference between the dental diode laser and scalpel groups.
Biosensor gives real-time wound-healing assessment - Theengineer.co.uk
Engineers and clinical academics at NTU and NUH have developed technology to be embedded into dressings so that they do not need to be continually removed and replaced to assess how a wound is healing.
Emerging Use of Negative Pressure Wound Therapy With Instillation - Woundsource.com
Article by Robin Lenz and Fahad Hussain.
Negative pressure wound therapy with instillation (NPWTi) is a modification of NPWT, gaining popularity in the past few years. NPWTi can irrigate the wound with various solutions between sessions of negative pressure treatment. NPWTi has the same properties of standard NPWT with the added ability to cleanse a wound.
Current knowledge of leptin in wound healing: A collaborative review - Frontiersin.org
Article by Chi Yuan, Jian Liao, Liying Zheng, Lingzhi Din, Xiao Teng, Xuesong Lin and Le Wang (China - Front. Pharmacol.).
The understanding of the specific role in each process (e.g., inflammatory, proliferative, and maturation phase) of wound repair is not entirely clear, and further studies are still warranted in both macrostructural and microscale factors.
Hybrid-Based Wound Dressings: Combination of Synthetic and Biopolymers - Mdpi.com
Article by Blessing Atim Aderibigbe (Eastern Cape, South Africa - Polymers).
This review article reports the efficacy of wound dressings prepared from a combination of synthetic and natural polymers.
Essentials of wound care: assessing and managing impaired skin integrity - Rcni.com
Article by Alexandra Selina Carlin (Nottingham, England - NursingStandard).
This article provides nurses with an overview of the assessment and management of impaired skin integrity using the TIMERS tool. It also discusses the importance of shared decision-making between nurses and patients when formulating a wound care regimen.
Excision and incision wound healing activity of apigenin (4',5,7-trihydroxyflavone) containing extracts of Carissa carandas Linn. fruits - Phcog.com
Article by Chanchal Kumar Mishra, Ashok Kumar Pattnaik, Pankaj Dagur, Dhiraj Kumar and Manik Ghosh (India - Pharmacognosy Magazine).
The EFCC ointment (20% w/w) showed a significant increase in wound healing activity, validating its use by the tribal people.
Recent advances in nanomedicines for regulation of macrophages in wound healing - PubMed
Abstract by Alireza Joorabloo and Tianqing Liu (Westmead, Australia - J Nanobiotechnology).
A knowledge test on pressure injury in adult intensive care patients: Development, validation, and item analysis - PubMed
Abstract by Laurien Botterman, Irene De Cock, Stijn I Blot and Sonia O Labeau (Ghent, Belgium - J Tissue Viability).
Carbon-Based Nanomaterials in Wound Care Management: A New and Pristine Strategy - Springer.com
Article by Nidhi Chauhan, Kirti Saxena and Utkarsh Jain (Noida, India - Biomedical Materials & Devices).
This review emphasizes wound care management in terms of their healing and dressing by carbon-based nanomaterials. Additionally, a brief introduction of traditional methods of wound care is also discussed with the modern approaches.
Exploring healthcare provider and patient perspectives on current outpatient care of venous leg ulcers and potential interventions to improve their treatment: a mixed methods study in the ulcus cruris care project - PubMed
Abstract by Regina Poß-Doering, Carolin Anders, Thomas Fleischhauer, Joachim Szecsenyi and Jonas D Senft (Heidelberg, Germany - BMC Prim Care).
Conservative management of full-thickness burn wounds using advanced moist dressings: a case report - PubMed
Abstract by Shigenori Masaki, Itaru Maeda and Takashi Kawamoto (Sapporo, Japan - Wounds).
Microenvironmental cue-regulated exosomes as therapeutic strategies for improving chronic wound healing - Nature.com
Article by Wei Dai, Yuchen Dong, Ting Han, Jing Wang, Bin Gao, Hui Guo, Feng Xu, Jing Li and Yufei Ma (Xi’an, China - NPG Asia Materials).
Recent advances in regulating the features and biological functions of cell-derived exosomes by biochemical and biophysical cues in the cell microenvironment are systematically summarized. Subsequently, microenvironmental cue-regulated exosomes as therapeutic strategies to improve chronic wound healing by regulating the inflammatory response, promoting cell proliferation and migration, facilitating angiogenesis, and regulating extracellular matrix (ECM) remodeling are discussed, and hydrogel-based exosome delivery systems used in the treatment of chronic wounds are highlighted.
Challenges around quantifying uncertainty in a holistic approach to hard-to-heal wound management: Health economic perspective - Wiley.com
Article by Vladica Veličković and Dina Janković (York, UK - International Wound Journal).
Holistic approach to hard-to-heal wound management represents a wide range of heterogeneous treatment pathways that requires careful scoping, transparent reporting, and often complex modelling to fully capture uncertainty in the economic evaluation of different treatment options. Failure to reflect these complexities in economic evaluation can lead to biased estimates of their value, and consequently their inappropriate use in practice.
Hydration and pressure ulcer prevention: a pilot study - Wounds-uk.com
Article by Karen Green (Leicester, UK - Wounds UK).
Through the use of an adapted version of the GULP Dehydration risk screening tool and the implementation of a hydration-focussed care plan, it may be possible for a nurse-led assessment to identify dehydration risk and plan care accordingly. A pilot study showed that 50% of the sample group gained an improved level of hydration throughout their hospital admission and a decrease in their Waterlow score.
An optimized mouse model of Staphylococcus aureus infected diabetic ulcers - Biomedcentral.com
Article by Ana Isabel Mendes, Maria João Peixoto, Alexandra Pinto Marques, Jorge Pedrosa and Alexandra Gabriel Fraga (Guimarães, Portugal - BMC Research Notes).
The authors present an optimized diabetic mouse model of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, that resemble key features of DFI, such as pathogen invasion through wound bed and surrounding tissue, necrosis, persistent inflammation and impaired wound healing.
Long-term improvement in the appearance of hypertrophic scars following a single treatment with acoustic subcision - A single center proof-of-concept study - Wiley.com
Article by Brenda LaTowsky, David W. Robertson and Christopher C. Capelli (USA - Lasers in Surgery and Medicine).
This proof-of-concept study showed that a single noninvasive acoustic subcision treatment session can safely provide statistically significant improvement in the appearance of hypertrophic scars with minimal treatment pain and meaningful participant satisfaction.
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis - Physiology.org
Abstract by Calen A. Steiner, Ian M. Cartwright, Cormac T. Taylor and Sean P. Colgan (Aurora, USA - American Journal of Physiology-Cell Physiology).
Comparison of the Efficiency of Epidermal Growth Factor and Negative Pressure Wound Therapy in Diabetic Foot Patients - PubMed
Abstract by Ahmet Çınar Yastı, Turgut Karaca, Murat Kendirci, Ali Emre Akgün, İbrahim Tayfun Şahiner and Merve Akın (Turkey - Int J Low Extrem Wounds).
Evaluation of the In Vitro Wound-Healing Potential of Ayahuasca - Mdpi.com
Article by Joana Gonçalves, Ângelo Luís, Eugenia Gallardo and Ana Paula Duarte (Covilhã, Portugal - Molecules).
The results showed that only one sample showed cytotoxicity and all the others promoted the migration of skin fibroblasts.
Examination of the effects of kefir on healing factors in a mice burn model infected with E.coli, S.aureus and P.aeruginosa using qRT-PCR - PubMed
Abstract by Songul Cetik Yildiz, Cemil Demir and Adnan Ayhanci (Turkey - Burns).
Polysaccharide Electrospun Nanofibers for Wound Healing Applications - Dovepress.com
Article by Guoxin Lijie Wang, Weisan Pan and Kai Chen (China - International Journal of Nanomedicine).
This paper reviews the preparation of polysaccharide nanofibers by electrospinning and their application prospects in the field of wound healing. A variety of polysaccharide nanofibers, including chitosan, starch, alginate, and hyaluronic acid are introduced.
Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up - Biomedcentral.com
Article by Che Zhang, Li Huang, Xiaofen Wang, Xiaoya Zhou, Xiaoxian Zhang, Ling Li, Jieying Wu, Meng Kou, Cheguo Cai, Qizhou Lian and Xihui Zhou (China - Stem Cell Research & Therapy).
Based on the current pilot study, the preliminary clinical benefits of hUC-MSCs on DFU healing were shown, including good tolerance, a shortened healing time to 1.5 months and a favorable 3-year amputation-free survival rate.
Investigation of the relationship between the use of complementary alternative medicine and illness perception and illness cognition in patients with diabetic foot ulcer - PubMd
Article by İlknur Özkan, Seçil Taylan and Cansu Polat Dünya (Turkey - J Tissue Viability).
Oleanolic acid stimulation of cell migration involves a biphasic signaling mechanism - Nature.com
Article by Javier Stelling-Férez, José Antonio Gabaldón and Francisco José Nicolás (Murcia, Spain - Scientific Reports).
Oleanolic acid (OA) induced the recruitment of regulator proteins to focal adhesions to dynamize these structures during migration. Moreover, OA changed paxillin distribution and activated focal adhesion kinase at focal adhesions.
Patient-driven discovery of CCN1 to rescue cutaneous wound healing in diabetes via the intracellular EIF3A/CCN1/ATG7 signaling by nanoparticle-enabled delivery - Sciencedirect.com
Article by Jing-Si Jiang, Jie Zang, Yi Ru, Ying Luo, Jian-Kun Song, Yue Luo, Xiao-Ya Fei, Zhan Zhang, Ying Zhang, Dan Yang, Mi Zhou, Qi-Long Chen, Yun Bai, Yong-Yong Li, Le Kuai and Bin Li (Shanghai, China - Biomaterials).
The authors' results illustrate a novel mechanism of intracellular EIF3A/CCN1/ATG7 axis triggered by nanoformulation and the therapeutic potential of CCN1-NP for DU management.
How to cleanse a wound - Rcni.com
Article by Matthew Wynn (Salford, England).
Wound cleansing is a routine element of wound care. However, unnecessary cleansing, inappropriate techniques and inappropriate use of cleansing solutions can negatively affect patient outcomes. Therefore, it is essential that nurses understand when and how to cleanse a wound, and are able to select the most appropriate solution to use based on a holistic wound assessment. Nurses undertaking wound cleansing must have the knowledge and skills required to do so safely and must work within their level of competence.
Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta-analysis - Wiley.com
Article by Daniel J. Romary, Sarah A. Landsberger, K. Nicole Bradner, Mirian Ramirez and Brian R. Leon (International Wound Journal).
Topical ozone contributed to enhanced wound healing in all studies.
High Glucose Induces Late Differentiation and Death of Human Oral Keratinocytes - Mdpi.com
Article by Junhe Shi, Chen Han, Dandan Chen, Harsh M. Trivedi, Hiba I. Bangash and Lin Chen (China, USA - CIMB).
The results showed that high glucose significantly inhibited TIGK proliferation and migration. High glucose also induced significant cell death through apoptosis and necrosis as determined by flow cytometry, especially at 120 h after high glucose treatment.
Topical therapy for pain management in malignant fungating wounds: A scoping review - PubMed
Abstract by Suzana Aparecida da Costa Ferreira, Carol Viviana Serna González, Magali Thum, Adriane Aparecida da Costa Faresin, Kevin Woo and Vera Lúcia Conceição de Gouveia Santos (Sao Paulo, Brazil - J Clin Nurs.).
Modulation of Inflammatory Responses by a Non-Invasive Physical Plasma Jet during Gingival Wound Healing - Mdpi.com
Article by Benedikt Eggers, Matthias Bernhard Stope, Jana Marciniak, Alexander Mustea, James Deschner, Marjan Nokhbehsaim and Franz-Josef Kramer (Germany, Cells).
The authors' study shows that non-invasive physical plasma application does not damage the gingival tissue and that the promotion of wound healing is also due to an anti-inflammatory component.
Surgical site infections: a scoping review on current intraoperative prevention measures - PubMed
Abstract by M. F. Bath, J. Davies, R. Suresh and M. R. Machesney (Trust, UK - Ann R Coll Surg Engl.).
Medicinal Plants from Latin America with Wound Healing Activity: Ethnomedicine, Phytochemistry, Preclinical and Clinical Studies – A Review - Mdpi.com
Article by Anuar Salazar-Gómez and Angel Josabad Alonso-Castro (Guanajuato, Mexico - Pharmaceuticals).
This review on the ethnomedicinal, phytochemical, and pharmacological studies, of medicinal plants from Latin America with wound healing activity, offers promising data for further studies, as well as providing new insights into their possible role in wound care.
Application of chitosan-based materials in surgical or postoperative hemostasis - Frontiersin.org
Article by Yuanliang Xia, Ruohan Yang, Hengyi Wang, Yuehong Li and Changfeng Fu (Changchun, China - Front. Mater.).
In this review, the authors introduce the physiological coagulation process and discuss the physicochemical properties of chitosan and its role in hemostasis. Furthermore, they discuss the advantages and disadvantages of chitosan-based hemostatic materials.
Correlation between Bacterial Wound Colonization and Skin-Graft Loss in Burn Patients - PubMed
Abstract by Lukas Wellkamp, Doha Obed, Anieto Onochie Matthias Enechukwu, Alperen Sabri Bingoel, Khaled Dastagir and Peter Maria Vogt (Hannover, Germany - J Burn Care Res.).
Stepping Up Wound Care: Advanced Wound Care Products - Woundsource.com
Unfortunately, not all wounds progress through healing easily. Certain pathophysiologic and metabolic conditions can alter the course of healing and impair or delay it, resulting in chronic, nonhealing wounds. The costs to treat nonhealing wounds can be high, and the patient’s quality of life can be impacted by any related loss of mobility or productivity. For these reasons, advanced wound care modalities and products may be introduced to help address underlying factors that impair the healing process.
Health-related quality of life and assessment in patients with lower limb lymphoedema: a systematic review - PubMed
Abstract by Comfort Chima, Sherly George, Bridget Murray, Zena Moore and Mary Costello (Ireland, Australia, Saudi Arabia, China, Belgium, UK - J Wound Care).
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