Hungarian Wound Care Society

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News from the field of wound care and wound healing - May, 2022

Medical device-related pressure injuries: Knowledge levels of nurses and factors affecting these - PubMed
Abstract by Münevver Sönmez and Arzu Bahar (Ankara, Turkey - J Tissue Viability).


Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study - Hindawi.com
Article by Kamyar Abbasi, Reza Eftekhar Ashtiani, Mitra Abdolahi, Maryam Hosseini, Reza Sayyad Soufdoost, Mostafa Alam and Sadaf Fani-Hanifeh (Tehran, Iran - Advances in Materials Science and Engineering). The collagen/ibuprofen group had significant outcomes compared with collagen and the control groups in wound healing and wound contraction. Collagen/ibuprofen hydrogel can be a potential hydrogel in accelerating wound healing.


Local problems need global solutions - the metabolic needs of regenerating organisms - PubMed
Abstract by Ines C Kübler, Jenny Kretzschmar, Marko Brankatschk and Tatiana Sandoval-Guzmán (UK, Germany - Wound Repair Regen.).


In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft - Medsci.org
Article by Lijun Zhang, Guangchao Xu, Yating Wei, Mingzhou Yuan, Yuanyuan Li, Meifang Yin, Chufen Chen, Guangtao Huang, Bin Shu and Jun Wu (China, Italy - International Journal of Medical Sciences). The authors report the first case of the “perfect regenerative healing” of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin.


These pioneering therapies are treating hard-to-heal wounds as never before - Nationalgeographic.co.uk
Article by Meril Davds Landau. New technologies are helping rebuild the skin of people with diabetic ulcers, deep burns, and other severe injuries.


Intra-Abdominal Pressure Monitoring During Negative Pressure Wound Therapy in the Open Abdomen - PubMed
Abstract by Taryn E Travis, Nicholas J Prindeze, Jeffrey W Shupp and Jack A Sava (Washington, USA - J Surg Res.).


A review of current advancements for wound healing: Biomaterial applications and medical devices - Wiley.com
Article by Xiaoxuan Deng, Maree Gould and M. Azam Ali (Journal of Biomedical Materials Research). Most medical devices encompass a wide range of products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, and silk fibroin) and synthetic (e.g., polyvinyl alcohol, polyethylene glycol, poly[lactic-co-glycolic acid], polycaprolactone, polylactic acid) polymers, as well as bioactive molecules (e.g., chemical drugs, silver, growth factors, stem cells, and plant compounds). This review addresses these medical devices with a focus on biomaterials and applications, aiming to deliver a critical theoretical reference for further research on chronic wound healing.


Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades - Mdpi.com
Article by Cameron Ryall, Sanjukta Duarah, Shuo Chen, Haijun Yu and Jingyuan Wen (New Zealand, China - Pharmaceutics). Many cultures prefer natural-product-based traditional therapies which are often cheaper and more available than their synthetic counterparts. Improving natural products’ effect can provide novel wound-healing therapies for those who trust traditional compounds over synthetic drugs to reduce medical inequalities.


Physical Activity Participation in People With an Active Diabetic Foot Ulceration: A Scoping Review - PubMed
Abstract by Magali Brousseau-Foley, Virginie Blanchette, François Trudeau and Julie Houle (Trois-Rivières, Canada - Can J Diabetes).


Development of a textile based protein sensor for monitoring the healing progress of a wound - Nature.com
Article by Yomna ElSaboni, John A. Hunt, Jessica Stanley, Christine Moffatt and Yang Wei (UK, Taiwan - Scientific Reports). This article focuses on the design and fabrication of flexible textile-based protein sensors to be embedded in wound dressings. Chronic wounds require continuous monitoring to prevent further complications and to determine the best course of treatment in the case of infection.


Effectiveness of moist dressings in wound healing after surgical suturing: A Bayesian network meta-analysis of randomised controlled trials - Wiley.com
Article by Wenjing Sun, Maojun Chen, Dan Duan, Wenjie Liu, Wenyao Cui and Li Li (China - IWJ). The moist healing theory proves that a moderately moist and airtight environment is conducive to wound healing. However, different moist dressings have different functions. The authors aim to evaluate the effects of moist dressings on wound healing after surgical suturing and identify superior moist dressings.


Wound Healing - Hmpgloballearningnetwork.com
In this 8:45 video, Dr. Liu, MD, discusses advancements, technologies, and challenges in wound healing.


The use of cyanoacrylate glue for skin grafts stabilisation: A retrospective multicenter study - PubMed
Abstract by Abdullah E Kattan, Hatan Mortada, Rema Alkahtani, Reem Bin Idris, Adnan G Gelidan and Taghreed Alhumsi (Riyadh, Saudi Arabia - Int Wound J.).


Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties - Frontiersin.org
Article by Shuyi Ning, Jie Zang, Bingyang Zhang, Xinchi Feng and Feng Qiu (Tianjin, China - Front. Pharmacol.). Five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.


Fibroblasts in Scar Formation: Biology and Clinical Translation - Hindawi.com
Article by Huan Qian, Yihan Shan, Ruicheng Gong, Danfeng Lin, Mengwen Zhang, Chen Wang and Lu Wang (China - Oxidative Medicine and Cellular Longevity). The authors systematically reviewed how fibroblasts behave in response to skin injuries, as well as their functions in regeneration and scar formation. Several biocompatible materials, including hydrogels and nanoparticles, were also suggested.


Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins - Nature.com
Article by Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, Ryuji Yokokawa, Takashi Miura, Toshiki Itoh, Kenichi Tsujita, Naoki Mochizuki and Shigetomo Fukuhara (Japan, USA - Nature Communications). The authors' data indicate that the TOCA family of F-BAR proteins are key actin regulatory proteins required for directed EC migration and sense mechanical cell stretching to regulate wound angiogenesis.


Closed-wound negative pressure therapy dressing after loop ostomy closure: a retrospective comparative study - Nature.com
Article by P. Curchod, D. Clerc, J. Jurt, M. Hubner, D. Hahnloser, N. Demartines and F. Grass (Lausanne, Switzerland - Scientific Reports). The authors' preliminary results suggest a potential benefit of systematic application of the NPWT device after loop ostomy closure. A randomized controlled study is needed.


How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature - Dovepress.com
Article by Feng Wang, Wenyao Zhang, Hao Li, Xiaonan Chen, Sining Feng and Ziqing Mei (Beijing, China - IJN). This review focuses on the effects of diabetes on wound healing, introduce the properties, preparation methods and action mechanism of nanoparticles in wound healing, and describe the effects and application status of various nanoparticle-loaded dressings in diabetes-related chronic wound healing.


Superabsorbent wound dressings versus foams dressings for the management of moderate-to-highly exuding venous leg ulcers in French settings: An early stage model-based economic evaluation - PubMed
Abstract by Vladica M Veličković, Pablo Arija Prieto, Milica Krga and Ana Maria Jorge (Austria, Germany, The Netherlands, Norway - J Tissue Viability).


Wound Healing Properties of Jasione montana Extracts and Their Main Secondary Metabolites - Frontiersin.org
Article by Aleksandra Maria Juszczak, Katarzyna Jakimiuk, Robert Czarnomysy, Jakub Władysław Strawa, Marijana Zovko Končić, Krzysztof Bielawski and Michał Tomczyk (Poland, Croatia - Front. Pharmacol.) Extracts from J. montana, which is flavonoid-rich, promote the viability and accelerate the migration of fibroblasts as well as moderate oxidant and inflammatory processes and elastase activity. Hence, they may be potentially useful for topical therapeutic applications to stimulate the wound healing process.


Factors that Slow Down Wound Healing - Humanbiosciences.com
The cause of a chronic wound or wound that has not healed in over 30 days, must be determined in order to control the underlying issues. A chronic wound is also explained as a skin wound that does not heal, heals slowly, or heals but recurs. Trauma, burns, skin malignancies, infection, or underlying medical disorders such as diabetes are only a few of the various reasons for chronic (ongoing) skin wounds.


Finding the Right Covering for a Wound - Generalsurgerynews.com
Article by Victoria Stern. The ultimate goal of wound care is to accelerate healing and prevent acute wounds from becoming chronic. Part of this process involves choosing a wound dressing that complements the characteristics of the wound.


Antibiotics-Free Compounds for Chronic Wound Healing - Mdpi.com
Article by David O. Oluwole, Lucy Coleman, William Buchanan, Tao Chen, Roberto M. La Ragione and Lian X. Liu (UK - Pharmaceutics). The studied compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.


Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis - Frontiersin.org
Article by Fan Feng, Mingying Liu, Lianhong Pan, Jiaqin Wu, Chunli Wang, Li Yang, Wanqian Liu, Wei Xu and Mingxing Lei (China - Front. Pharmacol.). The authors' findings underscore the importance of biomechanical factors in the formation and progression of keloids and highlight their regulatory value. These findings may help facilitate the development of pharmacological interventions that can ultimately prevent and reduce keloid formation and progression.


What Are the Advantages of Multilayer Compression Bandaging for Chronic Venous Insufficiency, Lymphedema, and Phlebolymphedema? - Woundsource.com
Article by Tia Gray and Donald Thomas. Conditions such as lymphedema, chronic venous insufficiency, and phlebolymphedema that manifest in patients with wounds can lead to catastrophic and life-threatening skin breakdown (degradation). Complications of infections associated with lymphedema include cellulitis, lymphangitis, lymphadenitis, and ulcerations where protein-rich fluid provides a perfect medium for microbial growth. However, multilayer compression bandaging could be a viable solution for these formidable conditions.


How the Identification of Chronic Wound Infection Can Be Improved With Technology - Woundsource.com
Article by Liping Tang. Infection is the single most likely cause of delayed healing in chronic wounds. In most cases, identification of chronic wound infection (e.g., diabetic foot ulcers and venous leg ulcers) is not obvious because chronic wounds do not exhibit the same classic inflammatory signs of infection as those found in acute wounds. However, culture could take a few days, and the results may not always be reliable because of sampling error. A fast and accurate diagnosis of wound infection would relieve the patient of significant discomfort and improve the treatment outcome.


Platelet rich fibrin containing nanofibrous dressing for wound healing application: Fabrication, characterization and biological evaluations - PubMed
Abstract by Marjan Mirhaj, Mohamadreza Tavakoli, Jaleh Varshosaz, Sheyda Labbaf, Farnoosh Jafarpour, Parvin Ahmaditabar, Saeideh Salehi and Nafise Kazemi (Iran - Mater Sci Eng C Mater Biol Appl.).


Plastic surgical repair of ulcer wounds of diabetic foot patients through systemic treatment and local infection control - PubMed
Abstract by Zhiyuan Wu, Jie Li, Zhanpeng Li, Haiyan Huang, Yucang Shi and Xiang Li (Zhanjiang, China - Ann Palliat Med.).


Inflammatory skin diseases and wounds - Wiley.com
Article by Joachim Dissemond and Marco Romanelli (BJD). Inflammatory skin diseases are a heterogeneous group that can often lead to very painful and poorly healing wounds due to vascular inflammation and/or vascular occlusion. The underlying complex diseases lead to increased morbidity and mortality rates.


Implementation of Pressure Injury Prevention Strategies in Acute Care: Results From the 2018-2019 International Pressure Injury Prevalence Survey - PubMed
Abstract by Laura E Edsberg, Jill Cox, Kimberly Koloms and Catherine A VanGilder-Freese (USA - J Wound Ostomy Continence Nurs.).


Effect of Micropower Vacuum Dressing on Promoting Wound Healing in Patients with I-II Diabetic Foot - Hindawi.com
Article by Cunren Chen, Xixiong Wang, Changli Liang and Haiwei Liu (Hainan, China - Evidence-Based Complementary and Alternative Medicine). MVD has significant effects in the treatment of I-II grades diabetic foot wounds and has few adverse reactions. It is an effective new method that can promote the growth of granulation tissue and epithelium and promote wound healing.


Finding the Optimal Surgical Incision Pattern – A Biomechanical Study - Mdpi.com
Article by Nikolaus Wachtel, Paul I. Heidekrueger, Carolin Brenner, Maximilian Endres, Rainer Burgkart, Carina Micheler, Niklas Thon and Denis Ehrl (Germany - JCM). The authors were able to demonstrate the superior biomechanical stability of alternative incision patterns, in particular the Zigzag incision. This is most likely caused by an improved distribution of tensile force across the wound due to the perpendicular placement of sutures.


Prediction of inpatient pressure ulcers based on routine healthcare data using machine learning methodology - PubMed
Abstract by Felix Walther, Luise Heinrich, Jochen Schmitt, Maria Eberlein-Gonska and Martin Roessler (Dresden, Germany - Sci. Rep.).


Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability - Mdpi.com
Article by Zhuoying Liu, Yixuan Zhang, Ji Youn Youn, Yabing Zhang, Ayako Makino, Jason X.-J. Yuan and Hua Cai (USA - Antioxidants). The authors' data demonstrate for the first time that flavored and nicotine-containing e-cigarettes induce endothelial dysfunction through excessive ROS production, resulting in decreased NO bioavailability, increased endothelial cell apoptosis, and impairment in angiogenesis and wound healing, especially under diabetic condition.


Skin necrosis following sclerotherapy. Part 1: Differential diagnosis based on classification of pathogenic mechanisms - PubMed
Abstract by Mina Kang, Anes Yang, Patricia Hannaford, David Connor and Kurosh Parsi (Australia - Phlebology).


Management and outcome of burn injuries during pregnancy: A systematic review and presentation of a comprehensive guideline - PubMed
Abstract by M L Dijkerman, M L Breederveld-Walters, A Pijpe and R S Breederveld (The Netherlands - Burns).


Silver nanoparticles with vanadium oxide nanowires loaded into electrospun dressings for efficient healing of bacterium-infected wounds - PubMed
Abstract by Lei Huang, Lei Yu, Xiaohui Yin, Yu Lin, Yuanhong Xu and Yusheng Niu (Qingdao, China - J Colloid Interface Sci.).


Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing - Nature.com
Article by Marjan Soleimanpour, Samaneh Sadat Mirhaji, Samira Jafari, Hossein Derakhshankhah, Fatemeh Mamashli, Hadi Nedaei, Mohammad Reza Karimi, Hamidreza Motasadizadeh, Yousef Fatahi, Atiyeh Ghasemi, Maryam Sadat Nezamtaheri, Mohadese Khajezade, Masoumeh Teimouri, Bahram Goliaei, Cédric Delattre and Ali Akbar Saboury (Iran, France - Scientific Reports). According to the findings from in vitro as well as in vivo studies, the designed hydrogel can be considered as a novel attractive wound dressing after further prerequisite assessments.


A Case of a Patient Who Successfully Achieved Early Wound Closure by Local Negative Pressure Wound Therapy (NPWT) against Compromised Wound Healing after Arterio-Venous Graft Infection - Mdpi.com
Article by Risa Kusuta, Keiji Shimazu, Kazuhiro Mizoguchi, Kazumasa Komura and Atsuo Tanaka (Osaka, Japan- Kidney and Dialysis). In the present report, authors report a case of a patient who successfully achieved safe and early wound closure by NPWT against compromised wound healing after AVG infection.


Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach - Frontiersin.org
Article by Maddalena Mastrogiacomo, Marta Nardini, Maria Chiara Collina, Cristiana Di Campli, Gilberto Filaci, Ranieri Cancedda and Teresa Odorisio (Italy - Front. Bioeng. Biotechnol.). This review summarizes the results obtained when the innovative treatments were adopted in preclinical animal models of diabetes and in diabetic patients, with a focus on allogeneic preparations.


How Dietary Protein and Collagen Dipeptides Improve Wound Healing - Hmpgloballearningnetwork.com
Article by Nancy Collins. Wound-specific nutrition supplements are becoming more refined and advanced as we learn more about the role of nutritional components such as citrulline and collagen dipeptides prolyl-hydroxyproline and hydroxyprolyl glycine, which have direct action on fibroblasts.


Croatian nurses' and nursing students' knowledge about pressure injury prevention - PubMed
Abstract by Snjezana Cukljek, Slađana Rezic, Sanja Ledinski Ficko, Ana Marija Hosnjak, Martina Smrekar and Ana Ljubas (Zagreb, Croatia - J Tissue Viability).


A Retrospective Analysis of the Relationship Between 25-OH-Vitamin D and Diabetic Foot Ulcer - Dovepress.com
Article by Fenglin Wang, Luyao Zhou, Di Zhu and Caizhe Yang (Beijing, China - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy). The authors' study confirms that 25-OH-vitamin D is closely correlated with DFU and that 25-OH-vitamin D is an independent protective factor for DFU.


Patient Populations: Barriers to Care - Woundsource.com
The most effective wound care is patient-centered and individualized. Consideration must be made for unique population characteristics during an inpatient stay to decrease the risk of hospital readmission or further wound complications.


Unavoidable Skin Breakdown Versus Pressure Injury: Continued Discussions - Woundsource.com
Article by Holly Hovan. Pressure injuries typically are the result of unrelieved pressure, shear, or force. In an inpatient or hospital setting, interventions are put into place to prevent pressure injuries based on evidence and patient risk.


Amputation Prevention: Representation Matters - Woundsource.com
Article by Christine Miller. Benjamin Franklin famously stated, “An ounce of prevention is worth a pound of cure.” This statement was made in reference to the importance of fire prevention in 18th century Philadelphia, but it aptly applies to modern diabetic limb salvage.


Managing Patient Populations and Health Equity - Woundsource.com
Complex wounds require increased attention, time, and resources to treat. Certain populations, including pediatric patients, immunocompromised patients, and older adults, are at higher risk of developing complex wounds as a result of age or comorbidities.


Do You Know the Six Pillars of Chronic Wound Care? - Woundsource.com
Article by Emily Greenstein. Clinicians who provide care to patients with chronic wounds can face many challenges. Categorizing chronic wound care into six pillars for management is a holistic way to provide evidence-based care to patients. Providing this type of care is cost-effective and also can improve outcome measures.


What is plasma fibroblast therapy? - Medicalnewstoday.com
Plasma fibroblast therapy refers to an aesthetic procedure that may help tighten and improve the appearance of the skin. Some healthcare professionals may offer this treatment as an alternative to laser, injection, or surgical therapies.


Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions - Frontiersin.org
Article by Massimiliano Marvasi, Monica Monici, Desirée Pantalone and Duccio Cavalieri (Florence, Italy - Front. Bioeng. Biotechnol.). A stronger understanding of the connections and metabolic network among bacteria, fungi, the host’s immune system and the host metabolism will support the basis for a better wound healing in Space.


Topical Management of Wound: A Narrative Review of Cadexomer Iodine Ointment Versus Povidone Iodine Ointment - Cureus.com
Article by Shubham Gupta Jr., Sangita Shinde and Raju K. Shinde. This review narrates the comparison of CI and PI for the management of wounds in the context of biofilm reduction, wound size reduction, and granulation tissue promotion.


Ultrasound-guided Axillary Brachial Plexus Block for the management of graft site pain during dressing change in the burn injured patient: a randomized control trial - PubMed
Abstract by Cienwen Town, Haakan Strand, James Johnson and André Van Zundert (Queensland, Australia - J Burn Care Res.).